                         SEQUENCE LISTING

<110>  1GLOBE HEALTH INSTITUTE LLC
       LI, Chiang J.
       UNNIRAMAN, Shyam
 
<120>  Novel Synthetic Biology-Based ADCC Technology

<130>  GHI-002PCT

<140>  PCT/US15/10708
<141>  2015-01-08

<150>  US61/925217
<151>  2014-01-08

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  1032
<212>  DNA
<213>  artificial

<220>
<223>  Fusion of human genetic materials

<400>  1
cttggagaca acatgtggtt cttgacaact ctgctccttt gggttccagt tgatgggcaa       60

gtggacacca caaaggcagt gatcactttg cagcctccat gggtcagcgt gttccaagag      120

gaaaccgtaa ccttgcattg tgaggtgctc catctgcctg ggagcagctc tacacagtgg      180

tttctcaatg gcacagccac tcagacctcg acccccagct acagaatcac ctctgccagt      240

gtcaatgaca gtggtgaata caggtgccag agaggtctct cagggcgaag tgaccccata      300

cagctggaaa tccacagagg ctggctacta ctgcaggtct ccagcagagt cttcacggaa      360

ggagaacctc tggccttgag gtgtcatgcg tggaaggata agctggtgta caatgtgctt      420

tactatcgaa atggcaaagc ctttaagttt ttccactgga attctaacct caccattctg      480

aaaaccaaca taagtcacaa tggcacctac cattgctcag gcatgggaaa gcatcgctac      540

acatcagcag gaatatctgt cactgtgaaa gagctatttc cagctccagt gctgaatgca      600

tctgtgacat ccccactcct ggaggggaat ctggtcaccc tgagctgtga aacaaagttg      660

ctcttgcaga ggcctggttt gcagctttac ttctccttct acatgggcag caagaccctg      720

cgaggcagga acacatcctc tgaataccaa atactaactg ctagaagaga agactctggg      780

ttatactggt gcgaggctgc cacagaggat ggaaatgtcc ttaagcgcag ccctgagttg      840

gagcttcaag tgcttggcct ccagttacca actcctgtct ggtttcatta ccaagtctct      900

ttctgcttgg tgatggtact cctttttgca gtggacacag gactatattt ctctgtgaag      960

acaaacattc gaagctcaac aagagactgg aaggaccata aatttaaatg gagaaaggac     1020

cctcaagaca aa                                                         1032


<210>  2
<211>  340
<212>  PRT
<213>  artificial

<220>
<223>  fusion of human genetic materials

<400>  2

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro 
        275                 280                 285             


Val Trp Phe His Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu Leu 
    290                 295                 300                 


Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg 
305                 310                 315                 320 


Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp 
                325                 330                 335     


Pro Gln Asp Lys 
            340 


<210>  3
<211>  1041
<212>  DNA
<213>  artificial

<220>
<223>  fusion sequence

<400>  3
cttggagaca acatgtggtt cttgacaact ctgctccttt gggttccagt tgatgggcaa       60

gtggacacca caaaggcagt gatcactttg cagcctccat gggtcagcgt gttccaagag      120

gaaaccgtaa ccttgcattg tgaggtgctc catctgcctg ggagcagctc tacacagtgg      180

tttctcaatg gcacagccac tcagacctcg acccccagct acagaatcac ctctgccagt      240

gtcaatgaca gtggtgaata caggtgccag agaggtctct cagggcgaag tgaccccata      300

cagctggaaa tccacagagg ctggctacta ctgcaggtct ccagcagagt cttcacggaa      360

ggagaacctc tggccttgag gtgtcatgcg tggaaggata agctggtgta caatgtgctt      420

tactatcgaa atggcaaagc ctttaagttt ttccactgga attctaacct caccattctg      480

aaaaccaaca taagtcacaa tggcacctac cattgctcag gcatgggaaa gcatcgctac      540

acatcagcag gaatatctgt cactgtgaaa gagctatttc cagctccagt gctgaatgca      600

tctgtgacat ccccactcct ggaggggaat ctggtcaccc tgagctgtga aacaaagttg      660

ctcttgcaga ggcctggttt gcagctttac ttctccttct acatgggcag caagaccctg      720

cgaggcagga acacatcctc tgaataccaa atactaactg ctagaagaga agactctggg      780

ttatactggt gcgaggctgc cacagaggat ggaaatgtcc ttaagcgcag ccctgagttg      840

gagcttcaag tgcttggttt ggcagtgtca accatctcat cattctttcc acctgggtac      900

caagtctctt tctgcttggt gatggtactc ctttttgcag tggacacagg actatatttc      960

tctgtgaaga caaacattcg aagctcaaca agagactgga aggaccataa atttaaatgg     1020

agaaaggacc ctcaagacaa a                                               1041


<210>  4
<211>  343
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  4

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Ala Val Ser Thr Ile 
        275                 280                 285             


Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met 
    290                 295                 300                 


Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr 
305                 310                 315                 320 


Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp 
                325                 330                 335     


Arg Lys Asp Pro Gln Asp Lys 
            340             


<210>  5
<211>  732
<212>  DNA
<213>  artificial

<220>
<223>  Fusion of human DNA

<400>  5
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tccggatctc ggagggacca gaggctgccc cccgatgccc acaagccccc tgggggaggc      180

agtttccgga cccccatcca agaggagcag gccgacgccc actccaccct ggccaagatc      240

ggatctcgtt tctctgttaa acggggcaga aagaaactcc tgtatatatt caaacaacca      300

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa      360

gaagaagaag gaggatgtga actgggatct agagtgaagt tcagcaggag cgcagacgcc      420

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag      480

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgcag      540

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      600

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt      660

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg      720

ccccctcgct aa                                                          732


<210>  6
<211>  243
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein of human genetic codes

<400>  6

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly Ser Arg Arg Asp Gln Arg 
        35                  40                  45              


Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr 
    50                  55                  60                  


Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
65                  70                  75                  80  


Gly Ser Arg Phe Ser Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                85                  90                  95      


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            100                 105                 110         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        115                 120                 125             


Gly Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    130                 135                 140                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
145                 150                 155                 160 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                165                 170                 175     


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            180                 185                 190         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        195                 200                 205             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    210                 215                 220                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
225                 230                 235                 240 


Pro Pro Arg 
            


<210>  7
<211>  1758
<212>  DNA
<213>  artificial

<220>
<223>  fusion of human DNAs

<400>  7
atgtggttct tgacaactct gctcctttgg gttccagttg atgggcaagt ggacaccaca       60

aaggcagtga tcactttgca gcctccatgg gtcagcgtgt tccaagagga aaccgtaacc      120

ttgcattgtg aggtgctcca tctgcctggg agcagctcta cacagtggtt tctcaatggc      180

acagccactc agacctcgac ccccagctac agaatcacct ctgccagtgt caatgacagt      240

ggtgaataca ggtgccagag aggtctctca gggcgaagtg accccataca gctggaaatc      300

cacagaggct ggctactact gcaggtctcc agcagagtct tcacggaagg agaacctctg      360

gccttgaggt gtcatgcgtg gaaggataag ctggtgtaca atgtgcttta ctatcgaaat      420

ggcaaagcct ttaagttttt ccactggaat tctaacctca ccattctgaa aaccaacata      480

agtcacaatg gcacctacca ttgctcaggc atgggaaagc atcgctacac atcagcagga      540

atatctgtca ctgtgaaaga gctatttcca gctccagtgc tgaatgcatc tgtgacatcc      600

ccactcctgg aggggaatct ggtcaccctg agctgtgaaa caaagttgct cttgcagagg      660

cctggtttgc agctttactt ctccttctac atgggcagca agaccctgcg aggcaggaac      720

acatcctctg aataccaaat actaactgct agaagagaag actctgggtt atactggtgc      780

gaggctgcca cagaggatgg aaatgtcctt aagcgcagcc ctgagttgga gcttcaagtg      840

cttggcctcc agttaccaac tcctgtctgg tttcattacc aagtctcttt ctgcttggtg      900

atggtactcc tttttgcagt ggacacagga ctatatttct ctgtgaagac aaacattcga      960

agctcaacaa gagactggaa ggaccataaa tttaaatgga gaaaggaccc tcaagacaaa     1020

ggatctagga gtaagaggag caggggcggg cacagtgact acatgaacat gactccccgc     1080

cgccccgggc ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc     1140

tatcgctccg gatctcggag ggaccagagg ctgccccccg atgcccacaa gccccctggg     1200

ggaggcagtt tccggacccc catccaagag gagcaggccg acgcccactc caccctggcc     1260

aagatcggat ctcgtttctc tgttaaacgg ggcagaaaga aactcctgta tatattcaaa     1320

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt     1380

ccagaagaag aagaaggagg atgtgaactg ggatctagag tgaagttcag caggagcgca     1440

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1500

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1560

ccgcagagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1620

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1680

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1740

gccctgcccc ctcgctaa                                                   1758


<210>  8
<211>  585
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein of human DNAs

<400>  8

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro 
        275                 280                 285             


Val Trp Phe His Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu Leu 
    290                 295                 300                 


Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg 
305                 310                 315                 320 


Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp 
                325                 330                 335     


Pro Gln Asp Lys Gly Ser Arg Ser Lys Arg Ser Arg Gly Gly His Ser 
            340                 345                 350         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly 
    370                 375                 380                 


Ser Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly 
385                 390                 395                 400 


Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His 
                405                 410                 415     


Ser Thr Leu Ala Lys Ile Gly Ser Arg Phe Ser Val Lys Arg Gly Arg 
            420                 425                 430         


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
        435                 440                 445             


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
    450                 455                 460                 


Glu Gly Gly Cys Glu Leu Gly Ser Arg Val Lys Phe Ser Arg Ser Ala 
465                 470                 475                 480 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                485                 490                 495     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            500                 505                 510         


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
        515                 520                 525             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    530                 535                 540                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
545                 550                 555                 560 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                565                 570                 575     


Leu His Met Gln Ala Leu Pro Pro Arg 
            580                 585 


<210>  9
<211>  1767
<212>  DNA
<213>  artificial

<220>
<223>  fusion of human DNAs

<400>  9
atgtggttct tgacaactct gctcctttgg gttccagttg atgggcaagt ggacaccaca       60

aaggcagtga tcactttgca gcctccatgg gtcagcgtgt tccaagagga aaccgtaacc      120

ttgcattgtg aggtgctcca tctgcctggg agcagctcta cacagtggtt tctcaatggc      180

acagccactc agacctcgac ccccagctac agaatcacct ctgccagtgt caatgacagt      240

ggtgaataca ggtgccagag aggtctctca gggcgaagtg accccataca gctggaaatc      300

cacagaggct ggctactact gcaggtctcc agcagagtct tcacggaagg agaacctctg      360

gccttgaggt gtcatgcgtg gaaggataag ctggtgtaca atgtgcttta ctatcgaaat      420

ggcaaagcct ttaagttttt ccactggaat tctaacctca ccattctgaa aaccaacata      480

agtcacaatg gcacctacca ttgctcaggc atgggaaagc atcgctacac atcagcagga      540

atatctgtca ctgtgaaaga gctatttcca gctccagtgc tgaatgcatc tgtgacatcc      600

ccactcctgg aggggaatct ggtcaccctg agctgtgaaa caaagttgct cttgcagagg      660

cctggtttgc agctttactt ctccttctac atgggcagca agaccctgcg aggcaggaac      720

acatcctctg aataccaaat actaactgct agaagagaag actctgggtt atactggtgc      780

gaggctgcca cagaggatgg aaatgtcctt aagcgcagcc ctgagttgga gcttcaagtg      840

cttggtttgg cagtgtcaac catctcatca ttctttccac ctgggtacca agtctctttc      900

tgcttggtga tggtactcct ttttgcagtg gacacaggac tatatttctc tgtgaagaca      960

aacattcgaa gctcaacaag agactggaag gaccataaat ttaaatggag aaaggaccct     1020

caagacaaag gatctaggag taagaggagc aggggcgggc acagtgacta catgaacatg     1080

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac     1140

ttcgcagcct atcgctccgg atctcggagg gaccagaggc tgccccccga tgcccacaag     1200

ccccctgggg gaggcagttt ccggaccccc atccaagagg agcaggccga cgcccactcc     1260

accctggcca agatcggatc tcgtttctct gttaaacggg gcagaaagaa actcctgtat     1320

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1380

tgccgatttc cagaagaaga agaaggagga tgtgaactgg gatctagagt gaagttcagc     1440

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1500

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1560

gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1620

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1680

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1740

cacatgcagg ccctgccccc tcgctaa                                         1767


<210>  10
<211>  588
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein of human DNAs

<400>  10

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Ala Val Ser Thr Ile 
        275                 280                 285             


Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met 
    290                 295                 300                 


Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr 
305                 310                 315                 320 


Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp 
                325                 330                 335     


Arg Lys Asp Pro Gln Asp Lys Gly Ser Arg Ser Lys Arg Ser Arg Gly 
            340                 345                 350         


Gly His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        355                 360                 365             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    370                 375                 380                 


Arg Ser Gly Ser Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys 
385                 390                 395                 400 


Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                405                 410                 415     


Asp Ala His Ser Thr Leu Ala Lys Ile Gly Ser Arg Phe Ser Val Lys 
            420                 425                 430         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        435                 440                 445             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    450                 455                 460                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Gly Ser Arg Val Lys Phe Ser 
465                 470                 475                 480 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                485                 490                 495     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            500                 505                 510         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
        515                 520                 525             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    530                 535                 540                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
545                 550                 555                 560 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                565                 570                 575     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            580                 585             


