                         SEQUENCE LISTING

<110>  Berg LLC and University of Miami 
       
<120>  Enolase 1 (ENO1) compositions and uses thereof

<130>  119992-10619

<140>	  NEW APPLICATION
<141>	  CONCURRENTLY HEREWITH

<150>  US 61/926,913
<151>  2014-01-13

<150>  US 62/009,783
<151>  2014-06-09

<150>  US 62/100,881
<151>  2015-01-07

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  2204
<212>  DNA
<213>  Homo sapiens

<400>  1
gtggggcccc agagcgacgc tgagtgcgtg cgggactcgg agtacgtgac ggagccccga       60

gctctcatgc ccgccacgcc gccccgggcc atcccccgga gccccggctc cgcacacccc      120

agttcggctc accggtccta tctggggcca gagtttcgcc cgcaccacta cagggccgct      180

ggggagtcgg ggccccccag atctgcccgc ctcaagtccg cgggacgtca cccccctttc      240

cacgctactg cagccgtcgc agtcccaccc ctttccggga ggtgagggaa tgagtgacgg      300

ctctcccgac gaatggcgag gcggagctga gggggcgtgc cccggaggcg ggaagtgggt      360

ggggctcgcc ttagctaggc aggaagtcgg cgcgggcggc gcggacagta tctgtgggta      420

cccggagcac ggagatctcg ccggctttac gttcacctcg gtgtctgcag caccctccgc      480

ttcctctcct aggcgacgag acccagtggc tagaagttca ccatgtctat tctcaagatc      540

catgccaggg agatctttga ctctcgcggg aatcccactg ttgaggttga tctcttcacc      600

tcaaaaggtc tcttcagagc tgctgtgccc agtggtgctt caactggtat ctatgaggcc      660

ctagagctcc gggacaatga taagactcgc tatatgggga agggtgtctc aaaggctgtt      720

gagcacatca ataaaactat tgcgcctgcc ctggttagca agaaactgaa cgtcacagaa      780

caagagaaga ttgacaaact gatgatcgag atggatggaa cagaaaataa atctaagttt      840

ggtgcgaacg ccattctggg ggtgtccctt gccgtctgca aagctggtgc cgttgagaag      900

ggggtccccc tgtaccgcca catcgctgac ttggctggca actctgaagt catcctgcca      960

gtcccggcgt tcaatgtcat caatggcggt tctcatgctg gcaacaagct ggccatgcag     1020

gagttcatga tcctcccagt cggtgcagca aacttcaggg aagccatgcg cattggagca     1080

gaggtttacc acaacctgaa gaatgtcatc aaggagaaat atgggaaaga tgccaccaat     1140

gtgggggatg aaggcgggtt tgctcccaac atcctggaga ataaagaagg cctggagctg     1200

ctgaagactg ctattgggaa agctggctac actgataagg tggtcatcgg catggacgta     1260

gcggcctccg agttcttcag gtctgggaag tatgacctgg acttcaagtc tcccgatgac     1320

cccagcaggt acatctcgcc tgaccagctg gctgacctgt acaagtcctt catcaaggac     1380

tacccagtgg tgtctatcga agatcccttt gaccaggatg actggggagc ttggcagaag     1440

ttcacagcca gtgcaggaat ccaggtagtg ggggatgatc tcacagtgac caacccaaag     1500

aggatcgcca aggccgtgaa cgagaagtcc tgcaactgcc tcctgctcaa agtcaaccag     1560

attggctccg tgaccgagtc tcttcaggcg tgcaagctgg cccaggccaa tggttggggc     1620

gtcatggtgt ctcatcgttc gggggagact gaagatacct tcatcgctga cctggttgtg     1680

gggctgtgca ctgggcagat caagactggt gccccttgcc gatctgagcg cttggccaag     1740

tacaaccagc tcctcagaat tgaagaggag ctgggcagca aggctaagtt tgccggcagg     1800

aacttcagaa accccttggc caagtaagct gtgggcaggc aagcccttcg gtcacctgtt     1860

ggctacacag acccctcccc tcgtgtcagc tcaggcagct cgaggccccc gaccaacact     1920

tgcaggggtc cctgctagtt agcgccccac cgccgtggag ttcgtaccgc ttccttagaa     1980

cttctacaga agccaagctc cctggagccc tgttggcagc tctagctttg cagtcgtgta     2040

attggcccaa gtcattgttt ttctcgcctc actttccacc aagtgtctag agtcatgtga     2100

gcctcgtgtc atctccgggg tggccacagg ctagatcccc ggtggttttg tgctcaaaat     2160

aaaaagcctc agtgacccat gagaataaaa aaaaaaaaaa aaaa                      2204


<210>  2
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  3
<211>  2567
<212>  DNA
<213>  Homo sapiens

<400>  3
aactaaagaa aagtttcccc atctcccagg agggttctgt gggccctcca gagatcatca       60

gcctcttcac gggctagaaa ggatccaggg aaggtctaac caatgacctg ccctgaatgg      120

tgagctgcag gtgtgtcatt tagtgtgatt ttcctgttga ctgactcata ggagccctgc      180

tctgtggcag agctagcctc tggctgtatt caaattgact tagtgtgtgt gcaacattga      240

cctttctaga gatagaacat gtggccaaat tacagaaaag cacatagggc tagatcacgc      300

attctcagtg gggcacccgg aaaactccaa aaaggctgca gggaggggac aatgatgaaa      360

tcaggttgtg aaacactggg ctggtgtcgc agtggtggtg ctgggtgttc agtcccgctt      420

taatgctgta agaagcactc tacacacacg aacatgttac catttgaccg ttgtttaatg      480

gcgtacgtgg ggacttagcc ggagcaggat gatgctgtgc cttgatggta atgagtgctc      540

agtaagtaag catttgtgga agattgaacg catggcccct gaaatgctct cctctgcttt      600

cctgccccct cactgtctct cactcgcagt ccttaatcac cggttctctt ctgagtctct      660

ctcatttttc cttcttcatc ctctgctggg caggcgtctc cagacccatt aagtatatta      720

atgagttcct ggcaccagcc ctgtgcactc aggtaactga ttgaacagcc tttagtctgc      780

agttggcgtt tccagtgcat ggtcttgcaa actaacctcc agtcagatcg ttctgagcca      840

gctgctgttt tgtgtggctc taaccctctg gggtcctagg taggagcact cagactgggc      900

cggaaagtcc tccgattctg gggggaaagg ggagaggggg aagaggtccc acagaaggtc      960

ccttggtggg cttccgcgtc ggcctcaaca gtggttctct ctaacaatgc tgctcaagcc     1020

tgttttaaag ttaatgtcag taatttgatt tgattgttcc ttccaggtgt ctcaaaggct     1080

gttgagcaca tcaataaaac tattgcgcct gccctggtta gcaagaaact gaacgtcaca     1140

gaacaagaga agattgacaa actgatgatc gagatggatg gaacagaaaa taaatctaag     1200

tttggtgcga acgccattct gggggtgtcc cttgccgtct gcaaagctgg tgccgttgag     1260

aagggggtcc ccctgtaccg ccacatcgct gacttggctg gcaactctga agtcatcctg     1320

ccagtcccgg cgttcaatgt catcaatggc ggttctcatg ctggcaacaa gctggccatg     1380

caggagttca tgatcctccc agtcggtgca gcaaacttca gggaagccat gcgcattgga     1440

gcagaggttt accacaacct gaagaatgtc atcaaggaga aatatgggaa agatgccacc     1500

aatgtggggg atgaaggcgg gtttgctccc aacatcctgg agaataaaga aggcctggag     1560

ctgctgaaga ctgctattgg gaaagctggc tacactgata aggtggtcat cggcatggac     1620

gtagcggcct ccgagttctt caggtctggg aagtatgacc tggacttcaa gtctcccgat     1680

gaccccagca ggtacatctc gcctgaccag ctggctgacc tgtacaagtc cttcatcaag     1740

gactacccag tggtgtctat cgaagatccc tttgaccagg atgactgggg agcttggcag     1800

aagttcacag ccagtgcagg aatccaggta gtgggggatg atctcacagt gaccaaccca     1860

aagaggatcg ccaaggccgt gaacgagaag tcctgcaact gcctcctgct caaagtcaac     1920

cagattggct ccgtgaccga gtctcttcag gcgtgcaagc tggcccaggc caatggttgg     1980

ggcgtcatgg tgtctcatcg ttcgggggag actgaagata ccttcatcgc tgacctggtt     2040

gtggggctgt gcactgggca gatcaagact ggtgcccctt gccgatctga gcgcttggcc     2100

aagtacaacc agctcctcag aattgaagag gagctgggca gcaaggctaa gtttgccggc     2160

aggaacttca gaaacccctt ggccaagtaa gctgtgggca ggcaagccct tcggtcacct     2220

gttggctaca cagacccctc ccctcgtgtc agctcaggca gctcgaggcc cccgaccaac     2280

acttgcaggg gtccctgcta gttagcgccc caccgccgtg gagttcgtac cgcttcctta     2340

gaacttctac agaagccaag ctccctggag ccctgttggc agctctagct ttgcagtcgt     2400

gtaattggcc caagtcattg tttttctcgc ctcactttcc accaagtgtc tagagtcatg     2460

tgagcctcgt gtcatctccg gggtggccac aggctagatc cccggtggtt ttgtgctcaa     2520

aataaaaagc ctcagtgacc catgagaata aaaaaaaaaa aaaaaaa                   2567


<210>  4
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ile Glu Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn 
1               5                   10                  15      


Ala Ile Leu Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu 
            20                  25                  30          


Lys Gly Val Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser 
        35                  40                  45              


Glu Val Ile Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser 
    50                  55                  60                  


His Ala Gly Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val 
65                  70                  75                  80  


Gly Ala Ala Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr 
                85                  90                  95      


His Asn Leu Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr 
            100                 105                 110         


Asn Val Gly Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys 
        115                 120                 125             


Glu Gly Leu Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr 
    130                 135                 140                 


Asp Lys Val Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg 
145                 150                 155                 160 


Ser Gly Lys Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg 
                165                 170                 175     


Tyr Ile Ser Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys 
            180                 185                 190         


Asp Tyr Pro Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp 
        195                 200                 205             


Gly Ala Trp Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly 
    210                 215                 220                 


Asp Asp Leu Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn 
225                 230                 235                 240 


Glu Lys Ser Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser 
                245                 250                 255     


Val Thr Glu Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp 
            260                 265                 270         


Gly Val Met Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile 
        275                 280                 285             


Ala Asp Leu Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala 
    290                 295                 300                 


Pro Cys Arg Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile 
305                 310                 315                 320 


Glu Glu Glu Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg 
                325                 330                 335     


Asn Pro Leu Ala Lys 
            340     


<210>  5
<211>  2423
<212>  DNA
<213>  Homo sapiens

<400>  5
acccgcgctc gtacgtgcgc ctccgccggc agctcctgac tcatcggggg ctccgggtca       60

catgcgcccg cgcggcccta taggcgcctc ctccgcccgc cgcccgggag ccgcagccgc      120

cgccgccact gccactcccg ctctctcagc gccgccgtcg ccaccgccac cgccaccgcc      180

actaccaccg tctgagtctg cagtcccgag atcccagcca tcatgtccat agagaagatc      240

tgggcccggg agatcctgga ctcccgcggg aaccccacag tggaggtgga tctctatact      300

gccaaaggtc ttttccgggc tgcagtgccc agtggagcct ctacgggcat ctatgaggcc      360

ctggagctga gggatggaga caaacagcgt tacttaggca aaggtgtcct gaaggcagtg      420

gaccacatca actccaccat cgcgccagcc ctcatcagct caggtctctc tgtggtggag      480

caagagaaac tggacaacct gatgctggag ttggatggga ctgagaacaa atccaagttt      540

ggggccaatg ccatcctggg tgtgtctctg gccgtgtgta aggcaggggc agctgagcgg      600

gaactgcccc tgtatcgcca cattgctcag ctggccggga actcagacct catcctgcct      660

gtgccggcct tcaacgtgat caatggtggc tctcatgctg gcaacaagct ggccatgcag      720

gagttcatga tcctcccagt gggagctgag agctttcggg atgccatgcg actaggtgca      780

gaggtctacc atacactcaa gggagtcatc aaggacaaat acggcaagga tgccaccaat      840

gtgggggatg aaggtggctt tgcccccaat atcctggaga acagtgaagc cttggagctg      900

gtgaaggaag ccatcgacaa ggctggctac acggaaaaga tcgttattgg catggatgtt      960

gctgcctcag agttttatcg tgatggcaaa tatgacttgg acttcaagtc tcccactgat     1020

ccttcccgat acatcactgg ggaccagctg ggggcactct accaggactt tgtcagggac     1080

tatcctgtgg tctccattga ggacccattt gaccaggatg attgggctgc ctggtccaag     1140

ttcacagcca atgtagggat ccagattgtg ggtgatgacc tgacagtgac caacccaaaa     1200

cgtattgagc gggcagtgga agaaaaggcc tgcaactgtc tgctgctcaa ggtcaaccag     1260

atcggctcgg tcactgaagc catccaagcg tgcaagctgg cccaggagaa tggctggggg     1320

gtcatggtga gtcatcgctc aggagagact gaggacacat tcattgctga cctggtggtg     1380

gggctgtgca caggccagat caagactggt gccccgtgcc gttctgaacg tctggctaaa     1440

tacaaccagc tcatgagaat tgaggaagag ctgggggatg aagctcgctt tgccggacat     1500

aacttccgta atcccagtgt gctgtgattc ctctgcttgc ctggagacgt ggaacctctg     1560

tctcatcctc ctggaacctt gctgtcctga tctgtgatag ttcaccccct gagatcccct     1620

gagccccagg gtgcccagaa cttccctgat tgacctgctc cgctgctcct tggcttacct     1680

gacctcttgc tgtctctgct cgccctcctt tctgtgccct actcattggg gttccgcact     1740

ttccacttct tcctttctct ttctctcttc cctcagaaac tagaaatgtg aatgaggatt     1800

attataaaag ggggtccgtg gaagaatgat cagcatctgt gatgggagcg tcagggttgg     1860

tgtgctgagg tgttagagag ggaccatgtg tcacttgtgc tttgctcttg tcccacgtgt     1920

cttccacttt gcatatgagc cgtgaactgt gcatagtgct gggatggagg ggagtgttgg     1980

gcatgtgatc acgcctggct aataaggctt tagtgtattt atttatttat ttattttatt     2040

tgtttttcat tcatcccatt aatcatttcc ccataactca atggcctaaa actggcctga     2100

cttgggggaa cgatgtgtct gtatttcatg tggctgtaga tcccaagatg actggggtgg     2160

gaggtcttgc tagaatggga agggtcatag aaagggcctt gacatcagtt cctttgtgtg     2220

tactcactga agcctgcgtt ggtccagagc ggaggctgtg tgcctggggg agttttcctc     2280

tatacatctc tccccaaccc taggttccct gttcttcctc cagctgcacc agagcaacct     2340

ctcactcccc atgccacgtt ccacagttgc caccacctct gtggcattga aatgagcacc     2400

tccattaaag tctgaatcag tgc                                             2423


<210>  6
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Ile Glu Lys Ile Trp Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Tyr Thr Ala Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gln Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Asp His Ile Asn Ser Thr Ile Ala Pro Ala Leu Ile Ser Ser 
65                  70                  75                  80  


Gly Leu Ser Val Val Glu Gln Glu Lys Leu Asp Asn Leu Met Leu Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Arg Glu Leu 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Gln Leu Ala Gly Asn Ser Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Glu 
                165                 170                 175     


Ser Phe Arg Asp Ala Met Arg Leu Gly Ala Glu Val Tyr His Thr Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Asp Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Ser Glu Ala Leu 
    210                 215                 220                 


Glu Leu Val Lys Glu Ala Ile Asp Lys Ala Gly Tyr Thr Glu Lys Ile 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asp Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Thr Asp Pro Ser Arg Tyr Ile Thr 
            260                 265                 270         


Gly Asp Gln Leu Gly Ala Leu Tyr Gln Asp Phe Val Arg Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Ala Trp 
    290                 295                 300                 


Ser Lys Phe Thr Ala Asn Val Gly Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Glu Arg Ala Val Glu Glu Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ala Ile Gln Ala Cys Lys Leu Ala Gln Glu Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Asp Glu Ala Arg Phe Ala Gly His Asn Phe Arg Asn Pro Ser 
            420                 425                 430         


Val Leu 
        


<210>  7
<211>  1536
<212>  DNA
<213>  Homo sapiens

<400>  7
ataaatgcgc agcctgagag ggggtgagct gacactgtcc cagctgccac ctagactcgg       60

agctccatcc aaacctccag cgaagacatc ccaggtcggg tgaatcttcc agccctgggg      120

gtggaggtag taaaggccat ggccatgcag aaaatctttg cccgggaaat cttggactcc      180

aggggcaacc ccacggtgga ggtggacctg cacacggcca agggccgatt ccgagcagct      240

gtgcccagtg gggcttccac gggtatctat gaggctctgg aactaagaga cggagacaaa      300

ggccgctacc tggggaaagg agtcctgaag gctgtggaga acatcaacaa tactctgggc      360

cctgctctgc tgcaaaagaa actaagcgtt gtggatcaag aaaaagttga caaatttatg      420

attgagctag atgggaccga gaataagtcc aagtttgggg ccaatgccat cctgggcgtg      480

tccttggccg tgtgtaaggc gggagcagct gagaaggggg tccccctgta ccgccacatc      540

gcagatctcg ctgggaaccc tgacctcata ctcccagtgc cagccttcaa tgtgatcaac      600

gggggctccc atgctggaaa caagctggcc atgcaggagt tcatgattct gcctgtggga      660

gccagctcct tcaaggaagc catgcgcatt ggcgccgagg tctaccacca cctcaagggg      720

gtcatcaagg ccaagtatgg gaaggatgcc accaatgtgg gtgatgaagg tggcttcgca      780

cccaacatcc tggagaacaa tgaggccctg gagctgctga agacggccat ccaggcggct      840

ggttacccag acaaggtggt gatcggcatg gatgtggcag catctgagtt ctatcgcaat      900

gggaagtacg atcttgactt caagtcgcct gatgatcccg cacggcacat cactggggag      960

aagctcggag agctgtataa gagctttatc aagaactatc ctgtggtctc catcgaagac     1020

ccctttgacc aggatgactg ggccacttgg acctccttcc tctcgggggt gaacatccag     1080

attgtggggg atgacttgac agtcaccaac cccaagagga ttgcccaggc cgttgagaag     1140

aaggcctgca actgtctgct gctgaaggtc aaccagatcg gctcggtgac cgaatcgatc     1200

caggcgtgca aactggctca gtctaatggc tggggggtga tggtgagcca ccgctctggg     1260

gagactgagg acacattcat tgctgacctt gtggtggggc tctgcacagg acagatcaag     1320

actggcgccc cctgccgctc ggagcgtctg gccaaataca accaactcat gaggatcgag     1380

gaggctcttg gggacaaggc aatctttgct ggacgcaagt tccgtaaccc gaaggccaag     1440

tgagaagctg gaggctccag gactccactg gacagaccca ggtcttccag acctgcttcc     1500

tgaaataaac actggtgcca accaagaaaa aaaaaa                               1536


<210>  8
<211>  1494
<212>  DNA
<213>  Homo sapiens

<400>  8
ataaatgcgc agcctgagag ggggtgagct gacactgtcc cagctgccac ctagactcgg       60

agctccatcc aaacctccag cgaagacatc ccagccatgg ccatgcagaa aatctttgcc      120

cgggaaatct tggactccag gggcaacccc acggtggagg tggacctgca cacggccaag      180

ggccgattcc gagcagctgt gcccagtggg gcttccacgg gtatctatga ggctctggaa      240

ctaagagacg gagacaaagg ccgctacctg gggaaaggag tcctgaaggc tgtggagaac      300

atcaacaata ctctgggccc tgctctgctg caaaagaaac taagcgttgt ggatcaagaa      360

aaagttgaca aatttatgat tgagctagat gggaccgaga ataagtccaa gtttggggcc      420

aatgccatcc tgggcgtgtc cttggccgtg tgtaaggcgg gagcagctga gaagggggtc      480

cccctgtacc gccacatcgc agatctcgct gggaaccctg acctcatact cccagtgcca      540

gccttcaatg tgatcaacgg gggctcccat gctggaaaca agctggccat gcaggagttc      600

atgattctgc ctgtgggagc cagctccttc aaggaagcca tgcgcattgg cgccgaggtc      660

taccaccacc tcaagggggt catcaaggcc aagtatggga aggatgccac caatgtgggt      720

gatgaaggtg gcttcgcacc caacatcctg gagaacaatg aggccctgga gctgctgaag      780

acggccatcc aggcggctgg ttacccagac aaggtggtga tcggcatgga tgtggcagca      840

tctgagttct atcgcaatgg gaagtacgat cttgacttca agtcgcctga tgatcccgca      900

cggcacatca ctggggagaa gctcggagag ctgtataaga gctttatcaa gaactatcct      960

gtggtctcca tcgaagaccc ctttgaccag gatgactggg ccacttggac ctccttcctc     1020

tcgggggtga acatccagat tgtgggggat gacttgacag tcaccaaccc caagaggatt     1080

gcccaggccg ttgagaagaa ggcctgcaac tgtctgctgc tgaaggtcaa ccagatcggc     1140

tcggtgaccg aatcgatcca ggcgtgcaaa ctggctcagt ctaatggctg gggggtgatg     1200

gtgagccacc gctctgggga gactgaggac acattcattg ctgaccttgt ggtggggctc     1260

tgcacaggac agatcaagac tggcgccccc tgccgctcgg agcgtctggc caaatacaac     1320

caactcatga ggatcgagga ggctcttggg gacaaggcaa tctttgctgg acgcaagttc     1380

cgtaacccga aggccaagtg agaagctgga ggctccagga ctccactgga cagacccagg     1440

tcttccagac ctgcttcctg aaataaacac tggtgccaac caagaaaaaa aaaa           1494


<210>  9
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Glu Asn Ile Asn Asn Thr Leu Gly Pro Ala Leu Leu Gln Lys 
65                  70                  75                  80  


Lys Leu Ser Val Val Asp Gln Glu Lys Val Asp Lys Phe Met Ile Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ser 
                165                 170                 175     


Ser Phe Lys Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His His Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Ala Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Asn Glu Ala Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gln Ala Ala Gly Tyr Pro Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asn Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ala Arg His Ile Thr 
            260                 265                 270         


Gly Glu Lys Leu Gly Glu Leu Tyr Lys Ser Phe Ile Lys Asn Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Thr Trp 
    290                 295                 300                 


Thr Ser Phe Leu Ser Gly Val Asn Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Gln Ala Val Glu Lys Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Ile Gln Ala Cys Lys Leu Ala Gln Ser Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Ala 
                405                 410                 415     


Leu Gly Asp Lys Ala Ile Phe Ala Gly Arg Lys Phe Arg Asn Pro Lys 
            420                 425                 430         


Ala Lys 
        


<210>  10
<211>  1365
<212>  DNA
<213>  Homo sapiens

<400>  10
ataaatgcgc agcctgagag ggggtgagct gacactgtcc cagctgccac ctagactcgg       60

agctccatcc aaacctccag cgaagacatc ccagccatgg ccatgcagaa aatctttgcc      120

cgggaaatct tggactccag gggcaacccc acggtggagg tggacctgca cacggccaag      180

ggccgattcc gagcagctgt gcccagtggg gcttccacgg gtatctatga ggctctggaa      240

ctaagagacg gagacaaagg ccgctacctg gggaaagcca agtttggggc caatgccatc      300

ctgggcgtgt ccttggccgt gtgtaaggcg ggagcagctg agaagggggt ccccctgtac      360

cgccacatcg cagatctcgc tgggaaccct gacctcatac tcccagtgcc agccttcaat      420

gtgatcaacg ggggctccca tgctggaaac aagctggcca tgcaggagtt catgattctg      480

cctgtgggag ccagctcctt caaggaagcc atgcgcattg gcgccgaggt ctaccaccac      540

ctcaaggggg tcatcaaggc caagtatggg aaggatgcca ccaatgtggg tgatgaaggt      600

ggcttcgcac ccaacatcct ggagaacaat gaggccctgg agctgctgaa gacggccatc      660

caggcggctg gttacccaga caaggtggtg atcggcatgg atgtggcagc atctgagttc      720

tatcgcaatg ggaagtacga tcttgacttc aagtcgcctg atgatcccgc acggcacatc      780

actggggaga agctcggaga gctgtataag agctttatca agaactatcc tgtggtctcc      840

atcgaagacc cctttgacca ggatgactgg gccacttgga cctccttcct ctcgggggtg      900

aacatccaga ttgtggggga tgacttgaca gtcaccaacc ccaagaggat tgcccaggcc      960

gttgagaaga aggcctgcaa ctgtctgctg ctgaaggtca accagatcgg ctcggtgacc     1020

gaatcgatcc aggcgtgcaa actggctcag tctaatggct ggggggtgat ggtgagccac     1080

cgctctgggg agactgagga cacattcatt gctgaccttg tggtggggct ctgcacagga     1140

cagatcaaga ctggcgcccc ctgccgctcg gagcgtctgg ccaaatacaa ccaactcatg     1200

aggatcgagg aggctcttgg ggacaaggca atctttgctg gacgcaagtt ccgtaacccg     1260

aaggccaagt gagaagctgg aggctccagg actccactgg acagacccag gtcttccaga     1320

cctgcttcct gaaataaaca ctggtgccaa ccaagaaaaa aaaaa                     1365


<210>  11
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Ala Lys Phe Gly 
    50                  55                  60                  


Ala Asn Ala Ile Leu Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala 
65                  70                  75                  80  


Ala Glu Lys Gly Val Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly 
                85                  90                  95      


Asn Pro Asp Leu Ile Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly 
            100                 105                 110         


Gly Ser His Ala Gly Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu 
        115                 120                 125             


Pro Val Gly Ala Ser Ser Phe Lys Glu Ala Met Arg Ile Gly Ala Glu 
    130                 135                 140                 


Val Tyr His His Leu Lys Gly Val Ile Lys Ala Lys Tyr Gly Lys Asp 
145                 150                 155                 160 


Ala Thr Asn Val Gly Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu 
                165                 170                 175     


Asn Asn Glu Ala Leu Glu Leu Leu Lys Thr Ala Ile Gln Ala Ala Gly 
            180                 185                 190         


Tyr Pro Asp Lys Val Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe 
        195                 200                 205             


Tyr Arg Asn Gly Lys Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro 
    210                 215                 220                 


Ala Arg His Ile Thr Gly Glu Lys Leu Gly Glu Leu Tyr Lys Ser Phe 
225                 230                 235                 240 


Ile Lys Asn Tyr Pro Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp 
                245                 250                 255     


Asp Trp Ala Thr Trp Thr Ser Phe Leu Ser Gly Val Asn Ile Gln Ile 
            260                 265                 270         


Val Gly Asp Asp Leu Thr Val Thr Asn Pro Lys Arg Ile Ala Gln Ala 
        275                 280                 285             


Val Glu Lys Lys Ala Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile 
    290                 295                 300                 


Gly Ser Val Thr Glu Ser Ile Gln Ala Cys Lys Leu Ala Gln Ser Asn 
305                 310                 315                 320 


Gly Trp Gly Val Met Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr 
                325                 330                 335     


Phe Ile Ala Asp Leu Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr 
            340                 345                 350         


Gly Ala Pro Cys Arg Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met 
        355                 360                 365             


Arg Ile Glu Glu Ala Leu Gly Asp Lys Ala Ile Phe Ala Gly Arg Lys 
    370                 375                 380                 


Phe Arg Asn Pro Lys Ala Lys 
385                 390     


