                         SEQUENCE LISTING

<110>  LFB et al
 
<120>  IMMUNOGLOBULINE ANTI-TOXINE DU CHARBON

<130>  BFF130656 CEB

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Ile Ser Gly Gly 
            20                  25                  30          


Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Leu Ile Tyr Gly Ser Thr Ala Asp Thr Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Gly Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  


Ser Leu Gln Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Gly Tyr Asn Phe Trp Ser Gly Glu Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Ala Val Val Thr Val Ser Ser 
        115                 120                 125 


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  2

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Tyr Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys His Ala Ser Gln Gly Ile Asn Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Leu Gln Tyr Asp Ser Ala Pro Leu 
                85                  90                  95      


Ala Phe Gly Pro Gly Thr Lys Leu Asp Ile Lys 
            100                 105         


<210>  3
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rgion constante de la chane lourde

<400>  3

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rgion constante de la chane lgre

<400>  4

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  5
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chane lourde sans peptide signal

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Ile Ser Gly Gly 
            20                  25                  30          


Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Leu Ile Tyr Gly Ser Thr Ala Asp Thr Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Gly Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  


Ser Leu Gln Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Gly Tyr Asn Phe Trp Ser Gly Glu Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Ala Val Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  6
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chane lgre sans peptide signal

<400>  6

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Tyr Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys His Ala Ser Gln Gly Ile Asn Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Leu Gln Tyr Asp Ser Ala Pro Leu 
                85                  90                  95      


Ala Phe Gly Pro Gly Thr Lys Leu Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  7
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chane lourde avec peptide signal

<400>  7

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro 
            20                  25                  30          


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Ile Ser 
        35                  40                  45              


Gly Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Leu Ile Tyr Gly Ser Thr Ala Asp Thr Arg Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Gly Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Leu Ser Leu Gln Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Gly Tyr Asn Phe Trp Ser Gly Glu Tyr Tyr 
        115                 120                 125             


Gly Leu Asp Ser Trp Gly Gln Gly Ala Val Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  8
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chane lgre avec peptide signal

<400>  8

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Tyr 
            20                  25                  30          


Val Gly Asp Lys Val Thr Ile Thr Cys His Ala Ser Gln Gly Ile Asn 
        35                  40                  45              


Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    50                  55                  60                  


Leu Ile Tyr Lys Ala Ser Ser Leu Leu Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
                85                  90                  95      


Gln Ser Glu Asp Phe Ala Ser Tyr Tyr Cys Leu Gln Tyr Asp Ser Ala 
            100                 105                 110         


Pro Leu Ala Phe Gly Pro Gly Thr Lys Leu Asp Ile Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         


<210>  9
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclotidique codant la partie variable de la chane 
       lourde

<400>  9
caggtgcagc tgcaggaatc tggccctggc ctgctgaagc ccagcgagac actgtctctg       60

acctgcgccg tgtccggcga ctctatcagc ggcggctact actggtcttg gatcaggcag      120

agccccggca agggcctgga atggatcggc ctgatctacg gcagcaccgc cgacaccaga      180

tacaacccca gcctgaaggg cagagtgacc atcagcaagg acaccagcaa gaaccagctg      240

tctctgcagc tgagaagcgt gaccgctgcc gacaccgccg tgtactactg tgccagaagc      300

ggctacaact tttggagcgg cgagtactac ggcctggact cttggggaca gggcgctgtc      360

gtgacagtgt ccagc                                                       375


<210>  10
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclotidique codant la partie variable de la chane 
       lgre

<400>  10
gccatccagc tgacccagag ccctagctct ctgagcgcct acgtgggcga caaagtgacc       60

atcacctgtc acgccagcca gggcatcaac agctggctgg cctggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacaag gccagcagcc tgctgagcgg cgtgcccagc      180

agattcagcg gctctggctc tggcaccgac tacaccctga ccatcagctc cctgcagagc      240

gaggacttcg ccagctacta ctgcctgcag tacgacagcg cccctctggc cttcggccct      300

ggaacaaagc tggacatcaa g                                                321


<210>  11
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclotidique codant la partie constante de la chane 
       lourde

<400>  11
gcctctacca agggcccaag cgtgttccct ctggccccta gcagcaagtc tacctctggc       60

ggaacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      120

tggaactctg gcgctctgac aagcggcgtg cacaccttcc ctgccgtgct gcagtctagc      180

ggcctgtaca gcctgagcag cgtcgtgact gtgccctcta gctctctggg cacccagacc      240

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggaaccc      300

aagagctgcg acaagaccca cacctgtcct ccctgtcctg cccctgaact gctgggcgga      360

ccttccgtgt tcctgttccc cccaaagcct aaggacaccc tgatgatcag caggaccccc      420

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggacc ctgaagtgaa gttcaattgg      480

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ctagagagga acagtacaac      540

agcacctaca gggtggtgtc tgtgctgaca gtgctgcacc aggactggct gaacggcaaa      600

gagtacaagt gcaaggtgtc caacaaggcc ctgccagccc ccatcgaaaa gaccatctcc      660

aaggccaagg gacagcctcg cgagccccag gtgtacacac tgcctcccag cagggacgag      720

ctgacaaaga atcaggtgtc cctgacctgt ctcgtgaaag gcttctaccc cagcgacatt      780

gccgtggaat gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg      840

ctggacagcg acggctcatt cttcctgtac tccaagctga ccgtggacaa gtccaggtgg      900

cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa ccactacacc      960

cagaagtccc tgagcctgag ccctggcaag                                       990


<210>  12
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclotidique codant la partie constante de la chane 
       lgre

<400>  12
aggaccgtgg ccgcaccaag tgtctttatc ttcccaccca gcgacgagca gctgaagtcc       60

ggcacagctt ccgtcgtgtg cctgctgaac aacttctacc ctagggaagc caaggtgcag      120

tggaaggtgg acaacgccct gcagtccggc aactcccagg aaagcgtgac cgagcaggac      180

agcaaggact ccacctacag cctgagcagc accctgacac tgagcaaggc cgactacgag      240

aaacataagg tgtacgcctg cgaagtgacc caccagggcc tgtctagccc cgtgaccaag      300

agcttcaaca ggggcgagtg c                                                321


<210>  13
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclotidique codant la chane lourde

<400>  13
caggtgcagc tgcaggaatc tggccctggc ctgctgaagc ccagcgagac actgtctctg       60

acctgcgccg tgtccggcga ctctatcagc ggcggctact actggtcttg gatcaggcag      120

agccccggca agggcctgga atggatcggc ctgatctacg gcagcaccgc cgacaccaga      180

tacaacccca gcctgaaggg cagagtgacc atcagcaagg acaccagcaa gaaccagctg      240

tctctgcagc tgagaagcgt gaccgctgcc gacaccgccg tgtactactg tgccagaagc      300

ggctacaact tttggagcgg cgagtactac ggcctggact cttggggaca gggcgctgtc      360

gtgacagtgt ccagcgcctc taccaagggc ccaagcgtgt tccctctggc ccctagcagc      420

aagtctacct ctggcggaac agccgccctg ggctgcctcg tgaaggacta ctttcccgag      480

cccgtgaccg tgtcctggaa ctctggcgct ctgacaagcg gcgtgcacac cttccctgcc      540

gtgctgcagt ctagcggcct gtacagcctg agcagcgtcg tgactgtgcc ctctagctct      600

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc ccagcaacac caaggtggac      660

aagaaggtgg aacccaagag ctgcgacaag acccacacct gtcctccctg tcctgcccct      720

gaactgctgg gcggaccttc cgtgttcctg ttccccccaa agcctaagga caccctgatg      780

atcagcagga cccccgaagt gacctgcgtg gtggtggatg tgtcccacga ggaccctgaa      840

gtgaagttca attggtacgt ggacggcgtg gaagtgcaca acgccaagac caagcctaga      900

gaggaacagt acaacagcac ctacagggtg gtgtctgtgc tgacagtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca aggccctgcc agcccccatc     1020

gaaaagacca tctccaaggc caagggacag cctcgcgagc cccaggtgta cacactgcct     1080

cccagcaggg acgagctgac aaagaatcag gtgtccctga cctgtctcgt gaaaggcttc     1140

taccccagcg acattgccgt ggaatgggag agcaacggcc agcccgagaa caactacaag     1200

accacccccc ctgtgctgga cagcgacggc tcattcttcc tgtactccaa gctgaccgtg     1260

gacaagtcca ggtggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg     1320

cacaaccact acacccagaa gtccctgagc ctgagccctg gcaag                     1365


<210>  14
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclotidique codant la chane lgre

<400>  14
gccatccagc tgacccagag ccctagctct ctgagcgcct acgtgggcga caaagtgacc       60

atcacctgtc acgccagcca gggcatcaac agctggctgg cctggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacaag gccagcagcc tgctgagcgg cgtgcccagc      180

agattcagcg gctctggctc tggcaccgac tacaccctga ccatcagctc cctgcagagc      240

gaggacttcg ccagctacta ctgcctgcag tacgacagcg cccctctggc cttcggccct      300

ggaacaaagc tggacatcaa gaggaccgtg gccgcaccaa gtgtctttat cttcccaccc      360

agcgacgagc agctgaagtc cggcacagct tccgtcgtgt gcctgctgaa caacttctac      420

cctagggaag ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaaagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgaca      540

ctgagcaagg ccgactacga gaaacataag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  15
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclotidique codant la chane lourde comprenant un 
       peptide signal en N-terminal

<400>  15
atgcgatggt cctggatctt cctgctgctg ctgagcatca ccagcgccaa cgctcaggtg       60

cagctgcagg aatctggccc tggcctgctg aagcccagcg agacactgtc tctgacctgc      120

gccgtgtccg gcgactctat cagcggcggc tactactggt cttggatcag gcagagcccc      180

ggcaagggcc tggaatggat cggcctgatc tacggcagca ccgccgacac cagatacaac      240

cccagcctga agggcagagt gaccatcagc aaggacacca gcaagaacca gctgtctctg      300

cagctgagaa gcgtgaccgc tgccgacacc gccgtgtact actgtgccag aagcggctac      360

aacttttgga gcggcgagta ctacggcctg gactcttggg gacagggcgc tgtcgtgaca      420

gtgtccagcg cctctaccaa gggcccaagc gtgttccctc tggcccctag cagcaagtct      480

acctctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      540

accgtgtcct ggaactctgg cgctctgaca agcggcgtgc acaccttccc tgccgtgctg      600

cagtctagcg gcctgtacag cctgagcagc gtcgtgactg tgccctctag ctctctgggc      660

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      720

gtggaaccca agagctgcga caagacccac acctgtcctc cctgtcctgc ccctgaactg      780

ctgggcggac cttccgtgtt cctgttcccc ccaaagccta aggacaccct gatgatcagc      840

aggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      900

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      960

cagtacaaca gcacctacag ggtggtgtct gtgctgacag tgctgcacca ggactggctg     1020

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgccagcccc catcgaaaag     1080

accatctcca aggccaaggg acagcctcgc gagccccagg tgtacacact gcctcccagc     1140

agggacgagc tgacaaagaa tcaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1200

agcgacattg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1260

ccccctgtgc tggacagcga cggctcattc ttcctgtact ccaagctgac cgtggacaag     1320

tccaggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac     1380

cactacaccc agaagtccct gagcctgagc cctggcaag                            1419


<210>  16
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclotidique codant la chane lgre comprenant un 
       peptide signal en N-terminal

<400>  16
atgcgatggt cctggatctt cctgctgctg ctgagcatca ccagcgccaa cgccgccatc       60

cagctgaccc agagccctag ctctctgagc gcctacgtgg gcgacaaagt gaccatcacc      120

tgtcacgcca gccagggcat caacagctgg ctggcctggt atcagcagaa gcccggcaag      180

gcccccaagc tgctgatcta caaggccagc agcctgctga gcggcgtgcc cagcagattc      240

agcggctctg gctctggcac cgactacacc ctgaccatca gctccctgca gagcgaggac      300

ttcgccagct actactgcct gcagtacgac agcgcccctc tggccttcgg ccctggaaca      360

aagctggaca tcaagaggac cgtggccgca ccaagtgtct ttatcttccc acccagcgac      420

gagcagctga agtccggcac agcttccgtc gtgtgcctgc tgaacaactt ctaccctagg      480

gaagccaagg tgcagtggaa ggtggacaac gccctgcagt ccggcaactc ccaggaaagc      540

gtgaccgagc aggacagcaa ggactccacc tacagcctga gcagcaccct gacactgagc      600

aaggccgact acgagaaaca taaggtgtac gcctgcgaag tgacccacca gggcctgtct      660

agccccgtga ccaagagctt caacaggggc gagtgc                                696


<210>  17
<211>  1448
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclotidique codant la chane lourde telle que 
       synthtise

<400>  17
gctagcgccg ccaccatgcg atggtcctgg atcttcctgc tgctgctgag catcaccagc       60

gccaacgctc aggtgcagct gcaggaatct ggccctggcc tgctgaagcc cagcgagaca      120

ctgtctctga cctgcgccgt gtccggcgac tctatcagcg gcggctacta ctggtcttgg      180

atcaggcaga gccccggcaa gggcctggaa tggatcggcc tgatctacgg cagcaccgcc      240

gacaccagat acaaccccag cctgaagggc agagtgacca tcagcaagga caccagcaag      300

aaccagctgt ctctgcagct gagaagcgtg accgctgccg acaccgccgt gtactactgt      360

gccagaagcg gctacaactt ttggagcggc gagtactacg gcctggactc ttggggacag      420

ggcgctgtcg tgacagtgtc cagcgcctct accaagggcc caagcgtgtt ccctctggcc      480

cctagcagca agtctacctc tggcggaaca gccgccctgg gctgcctcgt gaaggactac      540

tttcccgagc ccgtgaccgt gtcctggaac tctggcgctc tgacaagcgg cgtgcacacc      600

ttccctgccg tgctgcagtc tagcggcctg tacagcctga gcagcgtcgt gactgtgccc      660

tctagctctc tgggcaccca gacctacatc tgcaacgtga accacaagcc cagcaacacc      720

aaggtggaca agaaggtgga acccaagagc tgcgacaaga cccacacctg tcctccctgt      780

cctgcccctg aactgctggg cggaccttcc gtgttcctgt tccccccaaa gcctaaggac      840

accctgatga tcagcaggac ccccgaagtg acctgcgtgg tggtggatgt gtcccacgag      900

gaccctgaag tgaagttcaa ttggtacgtg gacggcgtgg aagtgcacaa cgccaagacc      960

aagcctagag aggaacagta caacagcacc tacagggtgg tgtctgtgct gacagtgctg     1020

caccaggact ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcca     1080

gcccccatcg aaaagaccat ctccaaggcc aagggacagc ctcgcgagcc ccaggtgtac     1140

acactgcctc ccagcaggga cgagctgaca aagaatcagg tgtccctgac ctgtctcgtg     1200

aaaggcttct accccagcga cattgccgtg gaatgggaga gcaacggcca gcccgagaac     1260

aactacaaga ccaccccccc tgtgctggac agcgacggct cattcttcct gtactccaag     1320

ctgaccgtgg acaagtccag gtggcagcag ggcaacgtgt tcagctgctc cgtgatgcac     1380

gaggccctgc acaaccacta cacccagaag tccctgagcc tgagccctgg caagtgatag     1440

ggcgcgcc                                                              1448


<210>  18
<211>  725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclotidique codant la chane lgre telle que 
       synthtise

<400>  18
actagtgccg ccaccatgcg atggtcctgg atcttcctgc tgctgctgag catcaccagc       60

gccaacgccg ccatccagct gacccagagc cctagctctc tgagcgccta cgtgggcgac      120

aaagtgacca tcacctgtca cgccagccag ggcatcaaca gctggctggc ctggtatcag      180

cagaagcccg gcaaggcccc caagctgctg atctacaagg ccagcagcct gctgagcggc      240

gtgcccagca gattcagcgg ctctggctct ggcaccgact acaccctgac catcagctcc      300

ctgcagagcg aggacttcgc cagctactac tgcctgcagt acgacagcgc ccctctggcc      360

ttcggccctg gaacaaagct ggacatcaag aggaccgtgg ccgcaccaag tgtctttatc      420

ttcccaccca gcgacgagca gctgaagtcc ggcacagctt ccgtcgtgtg cctgctgaac      480

aacttctacc ctagggaagc caaggtgcag tggaaggtgg acaacgccct gcagtccggc      540

aactcccagg aaagcgtgac cgagcaggac agcaaggact ccacctacag cctgagcagc      600

accctgacac tgagcaaggc cgactacgag aaacataagg tgtacgcctg cgaagtgacc      660

caccagggcc tgtctagccc cgtgaccaag agcttcaaca ggggcgagtg ctagtgaact      720

ctaga                                                                  725


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide signal

<400>  19

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala 
        


<210>  20
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  squence codant le peptide signal

<400>  20
atgcgatggt cctggatctt cctgctgctg ctgagcatca ccagcgccaa cgc              53


