                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
      PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120> NSD3 INHIBITORS FOR TREATMENT OF CANCERS

<130> 043214-080752-PCT

<140>
<141>

<150> 62/003,739
<151> 2014-05-28

<150> 61/931,334
<151> 2014-01-24

<160> 113   

<170> PatentIn version 3.5

<210> 1
<211> 5428
<212> DNA
<213> Homo sapiens

<400> 1
gggggctttg tgcgcggcgg cggcgggaga ggcggcggcg gcggccagca cggaggcgga       60

ggccgagggg gctgtgcaca ggtcgccgcg gagaggcgtg cgaattccga gccgagcgcc      120

gaggaccgtg ctacccaggc cgggctgcca gccgcaggct cctctctggc agcagcggcg      180

gcgcggcgac ccccgtccct cggcctcccc ttcccatccc acctcccgag ccttcctctt      240

cccgcagcac gcccggcccg gcccggccgt ggccctcctc agtgccggcc gccatggcag      300

aggcgtccgg cgcggggaaa atctagcccg gggatttcat gcggcctagc tcggttccgc      360

ctcctcctcg cgcggcccca gcggctgccc gcaccccagc cccactccgg gcctccgtgt      420

ctctcctgtg atcgcactga cacggccggg gggttagaat ggaacaaact gaaggcccga      480

tgagagaaag ggaaagttaa ggatgctgga gcagaacaat ggatttctct ttctctttca      540

tgcaagggat catgggaaac acaattcagc aaccacctca actcattgac tccgccaaca      600

tccgtcagga ggatgccttt gataacaaca gtgacattgc tgaagatggt ggccagacac      660

catatgaagc tactttgcag caaggctttc agtacccagc tacaacagaa gatcttcctc      720

cactcacaaa tgggtatcca tcatcaatca gtgtgtatga aactcaaacc aaataccagt      780

catataatca gtatcctaat gggtcagcca atggctttgg tgcagttaga aactttagcc      840

ccactgacta ttatcattca gaaattccaa acacaagacc acatgaaatt ctggaaaaac      900

cttcccctcc acagccacca cctcctcctt cggtaccaca aactgtgatt ccaaagaaga      960

ctggctcacc tgaaattaaa ctaaaaataa ccaaaactat ccagaatggc agggaattgt     1020

ttgagtcttc cctttgtgga gaccttttaa atgaagtaca ggcaagtgag cacacgaaat     1080

caaagcatga aagcagaaaa gaaaagagga aaaaaagcaa caagcatgac tcatcaagat     1140

ctgaagagcg caagtcacac aaaatcccca aattagaacc agaggaacaa aatagaccaa     1200

atgagagggt tgacactgta tcagaaaaac caagggaaga accagtacta aaagaggaag     1260

ccccagttca gccaatacta tcttctgttc caacaacgga agtgtccact ggtgttaagt     1320

ttcaggttgg cgatcttgtg tggtccaagg tgggaaccta tccttggtgg ccttgtatgg     1380

tttcaagtga tccccagctt gaggttcata ctaaaattaa cacaagaggt gcccgagaat     1440

atcatgtcca gttttttagc aaccagccag agagggcgtg ggttcatgaa aaacgggtac     1500

gagagtataa aggtcataaa cagtatgaag aattactggc tgaggcaacc aaacaagcca     1560

gcaatcactc tgagaaacaa aagattcgga aaccccgacc tcagagagaa cgtgctcagt     1620

gggatattgg cattgcccat gcagagaaag cattgaaaat gactcgagaa gaaagaatag     1680

aacagtatac ttttatttac attgataaac agcctgaaga ggctttatcc caagcaaaaa     1740

agagtgttgc ctccaaaacc gaagttaaaa aaacccgacg accaagatct gtgctgaata     1800

ctcagccaga acagaccaat gcaggggagg tggcctcctc actctcaagt actgaaattc     1860

ggagacatag ccagaggcgg cacacaagtg cggaagagga agagccaccg cctgttaaaa     1920

tagcctggaa aactgcggca gcaaggaaat ccttaccagc ttccattacg atgcacaaag     1980

ggagcctgga tttgcagaag tgtaacatgt ctccagttgt gaaaattgaa caagtgtttg     2040

ctcttcagaa tgctacaggg gatgggaaat ttatcgatca atttgtttat tcaacaaagg     2100

gaattggtaa caaaacagaa ataagtgtca gggggcaaga caggcttata atttctacac     2160

caaaccagag aaatgaaaag ccaacgcaga gtgtatcatc tcctgaagca acatctggtt     2220

ctacaggctc agtagaaaag aagcaacaga gaagatcaat tagaactcgt tctgaatcag     2280

agaaatccac tgaggttgtg ccaaagaaga agatcaaaaa ggagcaggtt gaaacagttc     2340

ctcaggctac agtgaagact ggattacaga aaggtgccag cgagatttca gattcctgta     2400

aacctctaaa gaaaaggagt cgcgcctcaa ctgatgtaga aatgactagt tcagcataca     2460

gagacacatc tgactccgat tctagaggac tgagtgacct gcaggtaggc tttggaaagc     2520

aagtagatag cccttcagct actgcagatg cagacgtttc tgatgtgcag tccatggatt     2580

caagtttgtc gagaagaggc actggaatga gtaagaagga cactgtatgt cagatttgtg     2640

aaagctctgg tgactctctg attccttgtg agggagagtg ctgcaaacac tttcacctgg     2700

agtgcctggg attggcatca cttcctgata gcaagttcat ctgcatggaa tgtaaaactg     2760

ggcagcaccc atgtttttcg tgtaaagtgt ctggtaaaga tgtgaagcgt tgttctgttg     2820

gtgcttgtgg gaaattttat catgaagcct gtgtccgcaa attccccact gccatctttg     2880

aatcaaaagg attccgctgt cctcagcact gctgctctgc ctgctctatg gagaaagata     2940

tccacaaagc aagtaaaggc cgcatgatga gatgtttaag atgtccagtt gcctatcact     3000

ctggagatgc ttgcattgcg gccggaagca tgttagtatc ctcctacatt ctcatctgta     3060

gtaatcattc caaacggagc agtaattctt ctgctgtaaa tgtaggcttt tgtttcgttt     3120

gtgccagagg gctgatagtt caggaccatt cagaccccat gttcagttca tatgcctata     3180

agtcccacta cctactgaat gaatcaaatc gtgctgagtt gatgaaatta cctatgattc     3240

cttcttcgtc agcttccaaa aagaaatgtg agaaaggtgg aagattgctc tgctgtgaat     3300

cgtgcccagc ttccttccac ccggaatgcc taagcataga aatgccagaa ggctgctgga     3360

attgtaatga ctgtaaagct ggcaagaaac tacattacaa gcagattgtt tgggtcaaat     3420

tgggaaatta cagatggtgg ccagcagaga tctgcaaccc caggtctgtg ccactgaaca     3480

tccagggcct taaacatgac ttgggggact tccctgtatt cttctttggt tctcatgact     3540

actactgggt acaccagggc agagtgttcc cttatgttga aggagacaaa agctttgctg     3600

aagggcagac tagtattaac aagaccttca aaaaggcact ggaagaagct gcaaaacgtt     3660

tccaggaatt gaaagcacaa agagaaagta aagaagccct agagattgaa aaaaactcaa     3720

gaaaaccccc tccctacaaa cacatcaaag ctaacaaagt aataggaaag gtgcagatcc     3780

aggttgctga cctgtcagag attccccgct gtaactgcaa gccagctgat gaaaaccctt     3840

gtggcttgga atcggagtgc ctgaacagaa tgttgcagta tgaatgccac ccgcaggtgt     3900

gcccagctgg agatcgttgt cagaaccagt gctttacaaa gagactatac cctgatgcag     3960

agatcatcaa aacggagcgg agaggctggg gcctcaggac caaaaggagc attaagaagg     4020

gtgaatttgt aaatgaatac gtcggtgaat taattgatga agaagaatgc agattgcgaa     4080

tcaagcgagc ccacgagaac agtgtaacta atttttatat gttaactgtt accaaggacc     4140

gtataattga tgccggccca aaaggaaatt attctcgctt catgaaccac agttgtaatc     4200

ccaactgtga aacacaaaag tggacagtga atggagatgt tcgagtggga ctatttgctc     4260

tctgtgatat tcctgcaggg atggagttaa catttaatta taacctagat tgtctgggca     4320

acggcagaac ggagtgccac tgtggagcag ataactgcag tggttttcta ggagtgcggc     4380

caaagtcggc atgtgcgtca acaaatgaag agaaggcaaa aaatgctaag ttaaaacaga     4440

agagacgaaa gatcaaaaca gaaccaaagc agatgcatga agattactgt tttcaatgtg     4500

gagatggtgg agagctggtc atgtgtgaca aaaaagactg tcccaaagca taccacctcc     4560

tatgccttaa cctgactcag ccaccatatg gaaagtggga gtgtccgtgg catcagtgcg     4620

atgagtgcag cagtgcagct gtttccttct gtgaattctg tccacattca ttttgtaaag     4680

atcatgaaaa gggggccctg gttccctctg cactggaagg ccgcctctgc tgctcggaac     4740

atgaccccat ggctcctgtg tcaccagaat actggagcaa gataaaatgt aaatgggaat     4800

cacaagatca tggagaagaa gtaaaagaat aaatgtgtgg tgtcccctcc tttctattta     4860

agtgaaaaaa gcaaatagat catgcattta aaaagaagag actgctacag tgcatacagc     4920

ctttgccatc ggaactgcct tattaaagca aaaatgggaa accagttcat gcaggcagaa     4980

gcagttggtg gtgtctggtt tttgtttgat ttggttggtt tgggattctt ttgtggaggg     5040

ttaaattccc ttggtctttt cttgcctttt attgtgcttc agtgccattg cagcttgaaa     5100

aagaaatgtt tttgctgtta aaataagaac aaagagaaaa gtaagttttg ttaatgagat     5160

aaatttaaag tctaagatgt gttccttggt tgtataaagc aaaagtagcc atcattcctt     5220

tatttatttt catttttagg aatttcaaga agtgtagttc aatagtctaa tcaagtgtgt     5280

gtgtgtttta agtaggaatc tgagaaagcc ctctaggaaa gggtatgata agctttatat     5340

acctctttac tgagcagtag gtaggctcac ttctctttcc cttcaaaatg cttttcatag     5400

tagagaaggg ctctatggaa gtattaaa                                        5428


<210> 2
<211> 1437
<212> PRT
<213> Homo sapiens

<400> 2
Met Asp Phe Ser Phe Ser Phe Met Gln Gly Ile Met Gly Asn Thr Ile 
1               5                   10                  15      


Gln Gln Pro Pro Gln Leu Ile Asp Ser Ala Asn Ile Arg Gln Glu Asp 
            20                  25                  30          


Ala Phe Asp Asn Asn Ser Asp Ile Ala Glu Asp Gly Gly Gln Thr Pro 
        35                  40                  45              


Tyr Glu Ala Thr Leu Gln Gln Gly Phe Gln Tyr Pro Ala Thr Thr Glu 
    50                  55                  60                  


Asp Leu Pro Pro Leu Thr Asn Gly Tyr Pro Ser Ser Ile Ser Val Tyr 
65                  70                  75                  80  


Glu Thr Gln Thr Lys Tyr Gln Ser Tyr Asn Gln Tyr Pro Asn Gly Ser 
                85                  90                  95      


Ala Asn Gly Phe Gly Ala Val Arg Asn Phe Ser Pro Thr Asp Tyr Tyr 
            100                 105                 110         


His Ser Glu Ile Pro Asn Thr Arg Pro His Glu Ile Leu Glu Lys Pro 
        115                 120                 125             


Ser Pro Pro Gln Pro Pro Pro Pro Pro Ser Val Pro Gln Thr Val Ile 
    130                 135                 140                 


Pro Lys Lys Thr Gly Ser Pro Glu Ile Lys Leu Lys Ile Thr Lys Thr 
145                 150                 155                 160 


Ile Gln Asn Gly Arg Glu Leu Phe Glu Ser Ser Leu Cys Gly Asp Leu 
                165                 170                 175     


Leu Asn Glu Val Gln Ala Ser Glu His Thr Lys Ser Lys His Glu Ser 
            180                 185                 190         


Arg Lys Glu Lys Arg Lys Lys Ser Asn Lys His Asp Ser Ser Arg Ser 
        195                 200                 205             


Glu Glu Arg Lys Ser His Lys Ile Pro Lys Leu Glu Pro Glu Glu Gln 
    210                 215                 220                 


Asn Arg Pro Asn Glu Arg Val Asp Thr Val Ser Glu Lys Pro Arg Glu 
225                 230                 235                 240 


Glu Pro Val Leu Lys Glu Glu Ala Pro Val Gln Pro Ile Leu Ser Ser 
                245                 250                 255     


Val Pro Thr Thr Glu Val Ser Thr Gly Val Lys Phe Gln Val Gly Asp 
            260                 265                 270         


Leu Val Trp Ser Lys Val Gly Thr Tyr Pro Trp Trp Pro Cys Met Val 
        275                 280                 285             


Ser Ser Asp Pro Gln Leu Glu Val His Thr Lys Ile Asn Thr Arg Gly 
    290                 295                 300                 


Ala Arg Glu Tyr His Val Gln Phe Phe Ser Asn Gln Pro Glu Arg Ala 
305                 310                 315                 320 


Trp Val His Glu Lys Arg Val Arg Glu Tyr Lys Gly His Lys Gln Tyr 
                325                 330                 335     


Glu Glu Leu Leu Ala Glu Ala Thr Lys Gln Ala Ser Asn His Ser Glu 
            340                 345                 350         


Lys Gln Lys Ile Arg Lys Pro Arg Pro Gln Arg Glu Arg Ala Gln Trp 
        355                 360                 365             


Asp Ile Gly Ile Ala His Ala Glu Lys Ala Leu Lys Met Thr Arg Glu 
    370                 375                 380                 


Glu Arg Ile Glu Gln Tyr Thr Phe Ile Tyr Ile Asp Lys Gln Pro Glu 
385                 390                 395                 400 


Glu Ala Leu Ser Gln Ala Lys Lys Ser Val Ala Ser Lys Thr Glu Val 
                405                 410                 415     


Lys Lys Thr Arg Arg Pro Arg Ser Val Leu Asn Thr Gln Pro Glu Gln 
            420                 425                 430         


Thr Asn Ala Gly Glu Val Ala Ser Ser Leu Ser Ser Thr Glu Ile Arg 
        435                 440                 445             


Arg His Ser Gln Arg Arg His Thr Ser Ala Glu Glu Glu Glu Pro Pro 
    450                 455                 460                 


Pro Val Lys Ile Ala Trp Lys Thr Ala Ala Ala Arg Lys Ser Leu Pro 
465                 470                 475                 480 


Ala Ser Ile Thr Met His Lys Gly Ser Leu Asp Leu Gln Lys Cys Asn 
                485                 490                 495     


Met Ser Pro Val Val Lys Ile Glu Gln Val Phe Ala Leu Gln Asn Ala 
            500                 505                 510         


Thr Gly Asp Gly Lys Phe Ile Asp Gln Phe Val Tyr Ser Thr Lys Gly 
        515                 520                 525             


Ile Gly Asn Lys Thr Glu Ile Ser Val Arg Gly Gln Asp Arg Leu Ile 
    530                 535                 540                 


Ile Ser Thr Pro Asn Gln Arg Asn Glu Lys Pro Thr Gln Ser Val Ser 
545                 550                 555                 560 


Ser Pro Glu Ala Thr Ser Gly Ser Thr Gly Ser Val Glu Lys Lys Gln 
                565                 570                 575     


Gln Arg Arg Ser Ile Arg Thr Arg Ser Glu Ser Glu Lys Ser Thr Glu 
            580                 585                 590         


Val Val Pro Lys Lys Lys Ile Lys Lys Glu Gln Val Glu Thr Val Pro 
        595                 600                 605             


Gln Ala Thr Val Lys Thr Gly Leu Gln Lys Gly Ala Ser Glu Ile Ser 
    610                 615                 620                 


Asp Ser Cys Lys Pro Leu Lys Lys Arg Ser Arg Ala Ser Thr Asp Val 
625                 630                 635                 640 


Glu Met Thr Ser Ser Ala Tyr Arg Asp Thr Ser Asp Ser Asp Ser Arg 
                645                 650                 655     


Gly Leu Ser Asp Leu Gln Val Gly Phe Gly Lys Gln Val Asp Ser Pro 
            660                 665                 670         


Ser Ala Thr Ala Asp Ala Asp Val Ser Asp Val Gln Ser Met Asp Ser 
        675                 680                 685             


Ser Leu Ser Arg Arg Gly Thr Gly Met Ser Lys Lys Asp Thr Val Cys 
    690                 695                 700                 


Gln Ile Cys Glu Ser Ser Gly Asp Ser Leu Ile Pro Cys Glu Gly Glu 
705                 710                 715                 720 


Cys Cys Lys His Phe His Leu Glu Cys Leu Gly Leu Ala Ser Leu Pro 
                725                 730                 735     


Asp Ser Lys Phe Ile Cys Met Glu Cys Lys Thr Gly Gln His Pro Cys 
            740                 745                 750         


Phe Ser Cys Lys Val Ser Gly Lys Asp Val Lys Arg Cys Ser Val Gly 
        755                 760                 765             


Ala Cys Gly Lys Phe Tyr His Glu Ala Cys Val Arg Lys Phe Pro Thr 
    770                 775                 780                 


Ala Ile Phe Glu Ser Lys Gly Phe Arg Cys Pro Gln His Cys Cys Ser 
785                 790                 795                 800 


Ala Cys Ser Met Glu Lys Asp Ile His Lys Ala Ser Lys Gly Arg Met 
                805                 810                 815     


Met Arg Cys Leu Arg Cys Pro Val Ala Tyr His Ser Gly Asp Ala Cys 
            820                 825                 830         


Ile Ala Ala Gly Ser Met Leu Val Ser Ser Tyr Ile Leu Ile Cys Ser 
        835                 840                 845             


Asn His Ser Lys Arg Ser Ser Asn Ser Ser Ala Val Asn Val Gly Phe 
    850                 855                 860                 


Cys Phe Val Cys Ala Arg Gly Leu Ile Val Gln Asp His Ser Asp Pro 
865                 870                 875                 880 


Met Phe Ser Ser Tyr Ala Tyr Lys Ser His Tyr Leu Leu Asn Glu Ser 
                885                 890                 895     


Asn Arg Ala Glu Leu Met Lys Leu Pro Met Ile Pro Ser Ser Ser Ala 
            900                 905                 910         


Ser Lys Lys Lys Cys Glu Lys Gly Gly Arg Leu Leu Cys Cys Glu Ser 
        915                 920                 925             


Cys Pro Ala Ser Phe His Pro Glu Cys Leu Ser Ile Glu Met Pro Glu 
    930                 935                 940                 


Gly Cys Trp Asn Cys Asn Asp Cys Lys Ala Gly Lys Lys Leu His Tyr 
945                 950                 955                 960 


Lys Gln Ile Val Trp Val Lys Leu Gly Asn Tyr Arg Trp Trp Pro Ala 
                965                 970                 975     


Glu Ile Cys Asn Pro Arg Ser Val Pro Leu Asn Ile Gln Gly Leu Lys 
            980                 985                 990         


His Asp Leu Gly Asp Phe Pro Val  Phe Phe Phe Gly Ser  His Asp Tyr 
        995                 1000                 1005             


Tyr Trp  Val His Gln Gly Arg  Val Phe Pro Tyr Val  Glu Gly Asp 
    1010                 1015                 1020             


Lys Ser  Phe Ala Glu Gly Gln  Thr Ser Ile Asn Lys  Thr Phe Lys 
    1025                 1030                 1035             


Lys Ala  Leu Glu Glu Ala Ala  Lys Arg Phe Gln Glu  Leu Lys Ala 
    1040                 1045                 1050             


Gln Arg  Glu Ser Lys Glu Ala  Leu Glu Ile Glu Lys  Asn Ser Arg 
    1055                 1060                 1065             


Lys Pro  Pro Pro Tyr Lys His  Ile Lys Ala Asn Lys  Val Ile Gly 
    1070                 1075                 1080             


Lys Val  Gln Ile Gln Val Ala  Asp Leu Ser Glu Ile  Pro Arg Cys 
    1085                 1090                 1095             


Asn Cys  Lys Pro Ala Asp Glu  Asn Pro Cys Gly Leu  Glu Ser Glu 
    1100                 1105                 1110             


Cys Leu  Asn Arg Met Leu Gln  Tyr Glu Cys His Pro  Gln Val Cys 
    1115                 1120                 1125             


Pro Ala  Gly Asp Arg Cys Gln  Asn Gln Cys Phe Thr  Lys Arg Leu 
    1130                 1135                 1140             


Tyr Pro  Asp Ala Glu Ile Ile  Lys Thr Glu Arg Arg  Gly Trp Gly 
    1145                 1150                 1155             


Leu Arg  Thr Lys Arg Ser Ile  Lys Lys Gly Glu Phe  Val Asn Glu 
    1160                 1165                 1170             


Tyr Val  Gly Glu Leu Ile Asp  Glu Glu Glu Cys Arg  Leu Arg Ile 
    1175                 1180                 1185             


Lys Arg  Ala His Glu Asn Ser  Val Thr Asn Phe Tyr  Met Leu Thr 
    1190                 1195                 1200             


Val Thr  Lys Asp Arg Ile Ile  Asp Ala Gly Pro Lys  Gly Asn Tyr 
    1205                 1210                 1215             


Ser Arg  Phe Met Asn His Ser  Cys Asn Pro Asn Cys  Glu Thr Gln 
    1220                 1225                 1230             


Lys Trp  Thr Val Asn Gly Asp  Val Arg Val Gly Leu  Phe Ala Leu 
    1235                 1240                 1245             


Cys Asp  Ile Pro Ala Gly Met  Glu Leu Thr Phe Asn  Tyr Asn Leu 
    1250                 1255                 1260             


Asp Cys  Leu Gly Asn Gly Arg  Thr Glu Cys His Cys  Gly Ala Asp 
    1265                 1270                 1275             


Asn Cys  Ser Gly Phe Leu Gly  Val Arg Pro Lys Ser  Ala Cys Ala 
    1280                 1285                 1290             


Ser Thr  Asn Glu Glu Lys Ala  Lys Asn Ala Lys Leu  Lys Gln Lys 
    1295                 1300                 1305             


Arg Arg  Lys Ile Lys Thr Glu  Pro Lys Gln Met His  Glu Asp Tyr 
    1310                 1315                 1320             


Cys Phe  Gln Cys Gly Asp Gly  Gly Glu Leu Val Met  Cys Asp Lys 
    1325                 1330                 1335             


Lys Asp  Cys Pro Lys Ala Tyr  His Leu Leu Cys Leu  Asn Leu Thr 
    1340                 1345                 1350             


Gln Pro  Pro Tyr Gly Lys Trp  Glu Cys Pro Trp His  Gln Cys Asp 
    1355                 1360                 1365             


Glu Cys  Ser Ser Ala Ala Val  Ser Phe Cys Glu Phe  Cys Pro His 
    1370                 1375                 1380             


Ser Phe  Cys Lys Asp His Glu  Lys Gly Ala Leu Val  Pro Ser Ala 
    1385                 1390                 1395             


Leu Glu  Gly Arg Leu Cys Cys  Ser Glu His Asp Pro  Met Ala Pro 
    1400                 1405                 1410             


Val Ser  Pro Glu Tyr Trp Ser  Lys Ile Lys Cys Lys  Trp Glu Ser 
    1415                 1420                 1425             


Gln Asp  His Gly Glu Glu Val  Lys Glu 
    1430                 1435         


<210> 3
<211> 1707
<212> DNA
<213> Homo sapiens

<400> 3
atggatttct ctttctcttt catgcaaggg atcatgggaa acacaattca gcaaccacct       60

caactcattg actccgccaa catccgtcag gaggatgcct ttgataacaa cagtgacatt      120

gctgaagatg gtggccagac accatatgaa gctactttgc agcaaggctt tcagtaccca      180

gctacaacag aagatcttcc tccactcaca aatgggtatc catcatcaat cagtgtgtat      240

gaaactcaaa ccaaatacca gtcatataat cagtatccta atgggtcagc caatggcttt      300

ggtgcagtta gaaactttag ccccactgac tattatcatt cagaaattcc aaacacaaga      360

ccacatgaaa ttctggaaaa accttcccct ccacagccac cacctcctcc ttcggtacca      420

caaactgtga ttccaaagaa gactggctca cctgaaatta aactaaaaat aaccaaaact      480

atccagaatg gcagggaatt gtttgagtct tccctttgtg gagacctttt aaatgaagta      540

caggcaagtg agcacacgaa atcaaagcat gaaagcagaa aagaaaagag gaaaaaaagc      600

aacaagcatg actcatcaag atctgaagag cgcaagtcac acaaaatccc caaattagaa      660

ccagaggaac aaaatagacc aaatgagagg gttgacactg tatcagaaaa accaagggaa      720

gaaccagtac taaaagagga agccccagtt cagccaatac tatcttctgt tccaacaacg      780

gaagtgtcca ctggtgttaa gtttcaggtt ggcgatcttg tgtggtccaa ggtgggaacc      840

tatccttggt ggccttgtat ggtttcaagt gatccccagc ttgaggttca tactaaaatt      900

aacacaagag gtgcccgaga atatcatgtc cagtttttta gcaaccagcc agagagggcg      960

tgggttcatg aaaaacgggt acgagagtat aaaggtcata aacagtatga agaattactg     1020

gctgaggcaa ccaaacaagc cagcaatcac tctgagaaac aaaagattcg gaaaccccga     1080

cctcagagag aacgtgctca gtgggatatt ggcattgccc atgcagagaa agcattgaaa     1140

atgactcgag aagaaagaat agaacagtat acttttattt acattgataa acagcctgaa     1200

gaggctttat cccaagcaaa aaagagtgtt gcctccaaaa ccgaagttaa aaaaacccga     1260

cgaccaagat ctgtgctgaa tactcagcca gaacagacca atgcagggga ggtggcctcc     1320

tcactctcaa gtactgaaat tcggagacat agccagaggc ggcacacaag tgcggaagag     1380

gaagagccac cgcctgttaa aatagcctgg aaaactgcgg cagcaaggaa atccttacca     1440

gcttccatta cgatgcacaa agggagcctg gatttgcaga agtgtaacat gtctccagtt     1500

gtgaaaattg aacaagtgtt tgctcttcag aatgctacag gggatgggaa atttatcgat     1560

caatttgttt attcaacaaa gggaattggt aacaaaacag aaataagtgt cagggggcaa     1620

gacaggctta taatttctac accaaaccag agaaatgaaa agccaacgca gagtgtatca     1680

tctcctgaag caacatctgg ttctaca                                         1707


<210> 4
<211> 569
<212> PRT
<213> Homo sapiens

<400> 4
Met Asp Phe Ser Phe Ser Phe Met Gln Gly Ile Met Gly Asn Thr Ile 
1               5                   10                  15      


Gln Gln Pro Pro Gln Leu Ile Asp Ser Ala Asn Ile Arg Gln Glu Asp 
            20                  25                  30          


Ala Phe Asp Asn Asn Ser Asp Ile Ala Glu Asp Gly Gly Gln Thr Pro 
        35                  40                  45              


Tyr Glu Ala Thr Leu Gln Gln Gly Phe Gln Tyr Pro Ala Thr Thr Glu 
    50                  55                  60                  


Asp Leu Pro Pro Leu Thr Asn Gly Tyr Pro Ser Ser Ile Ser Val Tyr 
65                  70                  75                  80  


Glu Thr Gln Thr Lys Tyr Gln Ser Tyr Asn Gln Tyr Pro Asn Gly Ser 
                85                  90                  95      


Ala Asn Gly Phe Gly Ala Val Arg Asn Phe Ser Pro Thr Asp Tyr Tyr 
            100                 105                 110         


His Ser Glu Ile Pro Asn Thr Arg Pro His Glu Ile Leu Glu Lys Pro 
        115                 120                 125             


Ser Pro Pro Gln Pro Pro Pro Pro Pro Ser Val Pro Gln Thr Val Ile 
    130                 135                 140                 


Pro Lys Lys Thr Gly Ser Pro Glu Ile Lys Leu Lys Ile Thr Lys Thr 
145                 150                 155                 160 


Ile Gln Asn Gly Arg Glu Leu Phe Glu Ser Ser Leu Cys Gly Asp Leu 
                165                 170                 175     


Leu Asn Glu Val Gln Ala Ser Glu His Thr Lys Ser Lys His Glu Ser 
            180                 185                 190         


Arg Lys Glu Lys Arg Lys Lys Ser Asn Lys His Asp Ser Ser Arg Ser 
        195                 200                 205             


Glu Glu Arg Lys Ser His Lys Ile Pro Lys Leu Glu Pro Glu Glu Gln 
    210                 215                 220                 


Asn Arg Pro Asn Glu Arg Val Asp Thr Val Ser Glu Lys Pro Arg Glu 
225                 230                 235                 240 


Glu Pro Val Leu Lys Glu Glu Ala Pro Val Gln Pro Ile Leu Ser Ser 
                245                 250                 255     


Val Pro Thr Thr Glu Val Ser Thr Gly Val Lys Phe Gln Val Gly Asp 
            260                 265                 270         


Leu Val Trp Ser Lys Val Gly Thr Tyr Pro Trp Trp Pro Cys Met Val 
        275                 280                 285             


Ser Ser Asp Pro Gln Leu Glu Val His Thr Lys Ile Asn Thr Arg Gly 
    290                 295                 300                 


Ala Arg Glu Tyr His Val Gln Phe Phe Ser Asn Gln Pro Glu Arg Ala 
305                 310                 315                 320 


Trp Val His Glu Lys Arg Val Arg Glu Tyr Lys Gly His Lys Gln Tyr 
                325                 330                 335     


Glu Glu Leu Leu Ala Glu Ala Thr Lys Gln Ala Ser Asn His Ser Glu 
            340                 345                 350         


Lys Gln Lys Ile Arg Lys Pro Arg Pro Gln Arg Glu Arg Ala Gln Trp 
        355                 360                 365             


Asp Ile Gly Ile Ala His Ala Glu Lys Ala Leu Lys Met Thr Arg Glu 
    370                 375                 380                 


Glu Arg Ile Glu Gln Tyr Thr Phe Ile Tyr Ile Asp Lys Gln Pro Glu 
385                 390                 395                 400 


Glu Ala Leu Ser Gln Ala Lys Lys Ser Val Ala Ser Lys Thr Glu Val 
                405                 410                 415     


Lys Lys Thr Arg Arg Pro Arg Ser Val Leu Asn Thr Gln Pro Glu Gln 
            420                 425                 430         


Thr Asn Ala Gly Glu Val Ala Ser Ser Leu Ser Ser Thr Glu Ile Arg 
        435                 440                 445             


Arg His Ser Gln Arg Arg His Thr Ser Ala Glu Glu Glu Glu Pro Pro 
    450                 455                 460                 


Pro Val Lys Ile Ala Trp Lys Thr Ala Ala Ala Arg Lys Ser Leu Pro 
465                 470                 475                 480 


Ala Ser Ile Thr Met His Lys Gly Ser Leu Asp Leu Gln Lys Cys Asn 
                485                 490                 495     


Met Ser Pro Val Val Lys Ile Glu Gln Val Phe Ala Leu Gln Asn Ala 
            500                 505                 510         


Thr Gly Asp Gly Lys Phe Ile Asp Gln Phe Val Tyr Ser Thr Lys Gly 
        515                 520                 525             


Ile Gly Asn Lys Thr Glu Ile Ser Val Arg Gly Gln Asp Arg Leu Ile 
    530                 535                 540                 


Ile Ser Thr Pro Asn Gln Arg Asn Glu Lys Pro Thr Gln Ser Val Ser 
545                 550                 555                 560 


Ser Pro Glu Ala Thr Ser Gly Ser Thr 
                565                 


<210> 5
<211> 249
<212> DNA
<213> Homo sapiens

<400> 5
tcggaggaag aggacaagtg caagcctatg tcctatgagg agaagcggca gctcagcttg       60

gacatcaaca agctccccgg cgagaagctg ggccgcgtgg tgcacatcat ccagtcacgg      120

gagccctccc tgaagaattc caaccccgac gagattgaaa tcgactttga gaccctgaag      180

ccgtccacac tgcgtgagct ggagcgctat gtcacctcct gtttgcggaa gaaaaggaaa      240

cctcaagct                                                              249


<210> 6
<211> 82
<212> PRT
<213> Homo sapiens

<400> 6
Ser Glu Glu Glu Asp Lys Cys Lys Pro Met Ser Tyr Glu Glu Lys Arg 
1               5                   10                  15      


Gln Leu Ser Leu Asp Ile Asn Lys Leu Pro Gly Glu Lys Leu Gly Arg 
            20                  25                  30          


Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu Lys Asn Ser Asn 
        35                  40                  45              


Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys Pro Ser Thr Leu 
    50                  55                  60                  


Arg Glu Leu Glu Arg Tyr Val Thr Ser Cys Leu Arg Lys Lys Arg Lys 
65                  70                  75                  80  


Pro Gln 
        


<210> 7
<211> 3795
<212> DNA
<213> Homo sapiens

<400> 7
gagttccgta ttctagttct gtgtgatctg atctttacct tcccttcctt ggatccctgt       60

gcacctactg gagccaggtt actctgggtc ctggacctga ctgcctcatt ctggaggctt      120

ccagacagcc acagttagtg cccaaacctg agaggatggc ttcagatgga gcatctgcat      180

tgccgggacc ggatatgagc atgaaaccta gtgccgccct gtctccatcc cctgcacttc      240

cctttctccc accaacttct gacccaccag accacccacc cagggagcca cctccacagc      300

ccatcatgcc ttcagtattc tctccagaca accctctgat gctctctgct ttccccagct      360

cactgttggt gacaggggac gggggccctt gcctcagtgg ggctggggct ggcaaggtca      420

ttgtcaaagt caagacagaa ggggggtcag ctgagccctc tcaaactcag aactttatcc      480

ttactcagac tgccctcaat tcgactgccc cgggcactcc ctgtggaggc cttgagggtc      540

ctgcacctcc atttgtgaca gcatctaatg tgaagaccat tctgccctct aaggctgttg      600

gtgtcagcca ggagggtcct ccaggccttc cgcctcagcc tccaccacca gttgctcaac      660

tggtccccat tgtgcccctg gaaaaagctt ggccagggcc acatgggaca accggggaag      720

gaggtcctgt ggccactcta tccaagcctt ccctaggtga ccgctccaaa atttccaagg      780

acgtttatga gaacttccgt cagtggcagc gttacaaagc cttggcccgg aggcacctat      840

cccagagtcc tgacacagaa gctctttcct gttttcttat cccagtgctt cgttccctgg      900

cccggctgaa gcccactatg accctggagg agggactgcc attggctgtg caggagtggg      960

agcacaccag caactttgac cggatgatct tttatgagat ggcagaaagg ttcatggagt     1020

ttgaggctga ggagatgcag attcagaaca cacagctgat gaatgggtct cagggcctgt     1080

ctcctgcaac ccctttgaaa cttgatcctc tagggcccct ggcctctgag gtttgccagc     1140

agccagtgta cattccgaag aaggcagcct ccaagacacg ggccccccgc cggcgtcagc     1200

gtaaagccca gagacctcct gctcctgagg cacccaagga gatcccacca gaagctgtga     1260

aggagtatgt tgacatcatg gaatggctgg tggggactca cttggccact ggggagtcag     1320

atggaaaaca agaggaagaa gggcagcagc aggaggagga agggatgtat ccagatccag     1380

gtctcctgag ctacatcaat gagctgtgtt ctcagaaggt ctttgtctcc aaggtggagg     1440

ctgtcattca ccctcaattt ctggcagatc tgctgtcccc agaaaaacag agagatccct     1500

tggccttaat tgaggagcta gagcaagaag aaggactcac tcttgcccag ctggtccaga     1560

agcgactcat ggccttggaa gaggaggaag atgcagaggc gcctccaagt ttcagtggcg     1620

ctcagttgga ctcaagtcct tctggttctg ttgaggatga agatggggat gggcggcttc     1680

ggccctcacc tgggcttcag ggggctgggg gcgccgcttg ccttggaaag gtttcttctt     1740

caggaaaacg ggcaagagaa gtgcatggtg ggcaggagca agccctagat agccccagag     1800

ggatgcacag ggatgggaac actctgccat cccccagcag ctgggacctg cagccagaac     1860

ttgcagctcc acagggaact ccgggaccct tgggtgtgga gaggagaggg tctgggaagg     1920

ttataaacca ggtatctcta catcaggatg gccatctagg aggcgctggg cctcctgggc     1980

actgcctggt ggctgatagg acttcagagg ctctgcccct ttgttggcag ggaggcttcc     2040

agcctgagag cactcccagt ttggatgctg gacttgcaga gctggctcct ctgcaaggac     2100

aagggttaga aaagcaagtc ctgggattgc agaaaggaca acaaacaggg ggtcgtggag     2160

tgcttcctca agggaaggag cctttagcag tgccctggga aggctcttca ggagccatgt     2220

ggggagatga cagaggtacc cccatggctc agagttatga tcagaatcct tcccctagag     2280

cagctgggga gagggacgat gtctgtctca gcccaggagt ttggctgagc agtgagatgg     2340

atgctgtagg cttggagctg cctgtacaaa tagaggaggt catagagagc ttccaagttg     2400

agaagtgtgt aactgagtat caggaaggct gccagggact gggctccagg ggcaacattt     2460

ccctgggtcc tggagaaacc ctagtacctg gggatacgga gagcagtgtg attccctgtg     2520

gaggcacagt tgcggcagct gccctagaaa agagaaacta ttgcagcttg ccaggacctt     2580

tgagggccaa cagcccaccc ttgaggtcca aagaaaatca agaacagagc tgtgaaaccg     2640

tagggcatcc cagtgatctg tgggcagaag gttgcttccc attgctagaa agtggtgatt     2700

ccacactggg gtcttccaaa gaaacccttc cacccacatg ccaaggcaat ctccttatca     2760

tggggactga ggatgcctcc tccttgcctg aagccagtca agaggcaggg agcagaggca     2820

attccttttc tcctctgttg gaaaccatag aacctgtcaa catactagat gttaaagatg     2880

actgtggcct ccaactaagg gtcagcgagg acacctgccc actgaatgtt cattcttatg     2940

acccccaagg agaaggcagg gtggatcctg atctgtccaa gcctaaaaac cttgctcctt     3000

tacaagagag tcaggagtct tacacaactg ggactcccaa agcaacatct tctcaccagg     3060

gccttggaag cactttgcct agaaggggaa ccaggaatgc catagttccg agagaaactt     3120

ctgttagtaa aacacacagg tcagcagaca gggccaaagg aaaggagaaa aagaaaaagg     3180

aagcagagga agaggatgag gaactctcca actttgctta cctcttggcc tctaaactta     3240

gcctctcacc aagggagcat cccctcagtc ctcaccatgc ctcaggaggt cagggcagcc     3300

agagagcatc ccacctgctc cctgctggag caaaaggccc cagcaaactt ccatatcctg     3360

ttgccaagtc tgggaagcga gctctagctg gaggtccagc ccctactgaa aagacacccc     3420

actcaggagc tcaacttggg gtccccaggg agaaacccct agctctggga gtagttcgac     3480

cctcacagcc tcgtaaaagg cggtgtgaca gttttgtcac gggcagaagg aagaaacgac     3540

gtcgtagcca gtagggagca gcgggaccat ctgaccccac ttgccagtcc ctaaaggtgg     3600

gtgccccaga gtagattcca cccctgctgc ccaccaatgg agaatcccaa tgttgaatct     3660

catcccaatg ttgttttgtt gttctgcaaa agtggcaagc atggagagag aggtcagact     3720

ggctaggctg cagggggaat tacctttgga aggagctata tagaaaaaaa atgaataaag     3780

tgttttgttg gaaaa                                                      3795


<210> 8
<211> 1131
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Ser Asp Gly Ala Ser Ala Leu Pro Gly Pro Asp Met Ser Met 
1               5                   10                  15      


Lys Pro Ser Ala Ala Leu Ser Pro Ser Pro Ala Leu Pro Phe Leu Pro 
            20                  25                  30          


Pro Thr Ser Asp Pro Pro Asp His Pro Pro Arg Glu Pro Pro Pro Gln 
        35                  40                  45              


Pro Ile Met Pro Ser Val Phe Ser Pro Asp Asn Pro Leu Met Leu Ser 
    50                  55                  60                  


Ala Phe Pro Ser Ser Leu Leu Val Thr Gly Asp Gly Gly Pro Cys Leu 
65                  70                  75                  80  


Ser Gly Ala Gly Ala Gly Lys Val Ile Val Arg Val Lys Thr Glu Gly 
                85                  90                  95      


Gly Ser Ala Glu Pro Ser Gln Thr Gln Asn Phe Ile Leu Thr Gln Thr 
            100                 105                 110         


Ala Leu Asn Ser Thr Ala Pro Gly Thr Pro Cys Gly Gly Leu Glu Gly 
        115                 120                 125             


Pro Ala Pro Pro Phe Val Thr Ala Ser Asn Val Lys Thr Ile Leu Pro 
    130                 135                 140                 


Ser Lys Ala Val Gly Val Ser Gln Glu Gly Pro Pro Gly Leu Pro Pro 
145                 150                 155                 160 


Gln Pro Pro Pro Pro Val Ala Gln Leu Val Pro Ile Val Pro Leu Glu 
                165                 170                 175     


Lys Ala Trp Pro Gly Pro His Gly Thr Thr Gly Glu Gly Gly Pro Val 
            180                 185                 190         


Ala Thr Leu Ser Lys Pro Ser Leu Gly Asp Arg Ser Lys Ile Ser Lys 
        195                 200                 205             


Asp Val Tyr Glu Asn Phe Arg Gln Trp Gln Arg Tyr Lys Ala Leu Ala 
    210                 215                 220                 


Arg Arg His Leu Ser Gln Ser Pro Asp Thr Glu Ala Leu Ser Cys Phe 
225                 230                 235                 240 


Leu Ile Pro Val Leu Arg Ser Leu Ala Arg Leu Lys Pro Thr Met Thr 
                245                 250                 255     


Leu Glu Glu Gly Leu Pro Leu Ala Val Gln Glu Trp Glu His Thr Ser 
            260                 265                 270         


Asn Phe Asp Arg Met Ile Phe Tyr Glu Met Ala Glu Arg Phe Met Glu 
        275                 280                 285             


Phe Glu Ala Glu Glu Met Gln Ile Gln Asn Thr Gln Leu Met Asn Gly 
    290                 295                 300                 


Ser Gln Gly Leu Ser Pro Ala Thr Pro Leu Lys Leu Asp Pro Leu Gly 
305                 310                 315                 320 


Pro Leu Ala Ser Glu Val Cys Gln Gln Pro Val Tyr Ile Pro Lys Lys 
                325                 330                 335     


Ala Ala Ser Lys Thr Arg Ala Pro Arg Arg Arg Gln Arg Lys Ala Gln 
            340                 345                 350         


Arg Pro Pro Ala Pro Glu Ala Pro Lys Glu Ile Pro Pro Glu Ala Val 
        355                 360                 365             


Lys Glu Tyr Val Asp Ile Met Glu Trp Leu Val Gly Thr His Leu Ala 
    370                 375                 380                 


Thr Gly Glu Ser Asp Gly Lys Gln Glu Glu Glu Gly Gln Gln Gln Glu 
385                 390                 395                 400 


Glu Glu Gly Met Tyr Pro Asp Pro Gly Leu Leu Ser Tyr Ile Asn Glu 
                405                 410                 415     


Leu Cys Ser Gln Lys Val Phe Val Ser Lys Val Glu Ala Val Ile His 
            420                 425                 430         


Pro Gln Phe Leu Ala Asp Leu Leu Ser Pro Glu Lys Gln Arg Asp Pro 
        435                 440                 445             


Leu Ala Leu Ile Glu Glu Leu Glu Gln Glu Glu Gly Leu Thr Leu Ala 
    450                 455                 460                 


Gln Leu Val Gln Lys Arg Leu Met Ala Leu Glu Glu Glu Glu Asp Ala 
465                 470                 475                 480 


Glu Ala Pro Pro Ser Phe Ser Gly Ala Gln Leu Asp Ser Ser Pro Ser 
                485                 490                 495     


Gly Ser Val Glu Asp Glu Asp Gly Asp Gly Arg Leu Arg Pro Ser Pro 
            500                 505                 510         


Gly Leu Gln Gly Ala Gly Gly Ala Ala Cys Leu Gly Lys Val Ser Ser 
        515                 520                 525             


Ser Gly Lys Arg Ala Arg Glu Val His Gly Gly Gln Glu Gln Ala Leu 
    530                 535                 540                 


Asp Ser Pro Arg Gly Met His Arg Asp Gly Asn Thr Leu Pro Ser Pro 
545                 550                 555                 560 


Ser Ser Trp Asp Leu Gln Pro Glu Leu Ala Ala Pro Gln Gly Thr Pro 
                565                 570                 575     


Gly Pro Leu Gly Val Glu Arg Arg Gly Ser Gly Lys Val Ile Asn Gln 
            580                 585                 590         


Val Ser Leu His Gln Asp Gly His Leu Gly Gly Ala Gly Pro Pro Gly 
        595                 600                 605             


His Cys Leu Val Ala Asp Arg Thr Ser Glu Ala Leu Pro Leu Cys Trp 
    610                 615                 620                 


Gln Gly Gly Phe Gln Pro Glu Ser Thr Pro Ser Leu Asp Ala Gly Leu 
625                 630                 635                 640 


Ala Glu Leu Ala Pro Leu Gln Gly Gln Gly Leu Glu Lys Gln Val Leu 
                645                 650                 655     


Gly Leu Gln Lys Gly Gln Gln Thr Gly Gly Arg Gly Val Leu Pro Gln 
            660                 665                 670         


Gly Lys Glu Pro Leu Ala Val Pro Trp Glu Gly Ser Ser Gly Ala Met 
        675                 680                 685             


Trp Gly Asp Asp Arg Gly Thr Pro Met Ala Gln Ser Tyr Asp Gln Asn 
    690                 695                 700                 


Pro Ser Pro Arg Ala Ala Gly Glu Arg Asp Asp Val Cys Leu Ser Pro 
705                 710                 715                 720 


Gly Val Trp Leu Ser Ser Glu Met Asp Ala Val Gly Leu Glu Leu Pro 
                725                 730                 735     


Val Gln Ile Glu Glu Val Ile Glu Ser Phe Gln Val Glu Lys Cys Val 
            740                 745                 750         


Thr Glu Tyr Gln Glu Gly Cys Gln Gly Leu Gly Ser Arg Gly Met Ile 
        755                 760                 765             


Ser Leu Gly Pro Gly Glu Thr Leu Val Pro Gly Asp Thr Glu Ser Ser 
    770                 775                 780                 


Val Ile Pro Cys Gly Gly Thr Val Ala Ala Ala Ala Leu Glu Lys Arg 
785                 790                 795                 800 


Asn Tyr Cys Ser Leu Pro Gly Pro Leu Arg Ala Asn Ser Pro Pro Leu 
                805                 810                 815     


Arg Ser Lys Glu Asn Gln Glu Gln Ser Cys Glu Thr Val Gly His Pro 
            820                 825                 830         


Ser Asp Leu Trp Ala Glu Gly Cys Phe Pro Leu Leu Glu Ser Gly Asp 
        835                 840                 845             


Ser Thr Leu Gly Ser Ser Lys Glu Thr Leu Pro Pro Thr Cys Gln Gly 
    850                 855                 860                 


Asn Leu Leu Ile Met Gly Thr Glu Asp Ala Ser Ser Leu Pro Glu Ala 
865                 870                 875                 880 


Ser Gln Glu Ala Gly Ser Arg Gly Ser Phe Ser Pro Leu Leu Glu Thr 
                885                 890                 895     


Ile Glu Pro Val Asn Ile Leu Asp Val Lys Asp Asp Cys Gly Leu Gln 
            900                 905                 910         


Leu Arg Val Ser Glu Asp Thr Cys Pro Leu Asn Val His Ser Tyr Asp 
        915                 920                 925             


Pro Gln Gly Glu Gly Arg Val Asp Pro Asp Leu Ser Lys Pro Lys Asn 
    930                 935                 940                 


Leu Ala Pro Leu Gln Glu Ser Gln Glu Ser Tyr Thr Thr Gly Thr Pro 
945                 950                 955                 960 


Lys Ala Thr Ser Ser His Gln Gly Leu Gly Ser Thr Leu Pro Arg Arg 
                965                 970                 975     


Gly Thr Arg Asn Ala Ile Val Pro Arg Glu Thr Ser Val Ser Lys Thr 
            980                 985                 990         


His Arg Ser Ala Asp Arg Ala Lys  Gly Lys Glu Lys Lys  Lys Lys Glu 
        995                 1000                 1005             


Ala Glu  Glu Glu Asp Glu Glu  Leu Ser Asn Phe Ala  Tyr Leu Leu 
    1010                 1015                 1020             


Ala Ser  Lys Leu Ser Leu Ser  Pro Arg Glu His Pro  Leu Ser Pro 
    1025                 1030                 1035             


His His  Ala Ser Gly Gly Gln  Gly Ser Gln Arg Ala  Ser His Leu 
    1040                 1045                 1050             


Leu Pro  Ala Gly Ala Lys Gly  Pro Ser Lys Leu Pro  Tyr Pro Val 
    1055                 1060                 1065             


Ala Lys  Ser Gly Lys Arg Ala  Leu Ala Gly Gly Pro  Ala Pro Thr 
    1070                 1075                 1080             


Glu Lys  Thr Pro His Ser Gly  Ala Gln Leu Gly Val  Pro Arg Glu 
    1085                 1090                 1095             


Lys Pro  Leu Ala Leu Gly Val  Val Arg Pro Ser Gln  Pro Arg Lys 
    1100                 1105                 1110             


Arg Arg  Cys Asp Ser Phe Val  Thr Gly Arg Arg Lys  Lys Arg Arg 
    1115                 1120                 1125             


Arg Ser  Gln 
    1130     


<210> 9
<211> 5198
<212> DNA
<213> Homo sapiens

<400> 9
attctttgga atactactgc tagaagtctg acttaagacc cagcttatgg gccacatggc       60

acccagctgc ttctgcagag aaggcaggcc actgatgggt acagcaaagt gtggtgctgc      120

tggccaagcc aaagacccgt gtaggatgac tgggcctctg ccccttgtgg gtgttgccac      180

tgtgcttgag tgcctggtga agaatgtgat gggatcacta gcatgtctgc ggagagcggc      240

cctgggacga gattgagaaa tctgccagta atgggggatg gactagaaac ttcccaaatg      300

tctacaacac aggcccaggc ccaaccccag ccagccaacg cagccagcac caaccccccg      360

cccccagaga cctccaaccc taacaagccc aagaggcaga ccaaccaact gcaatacctg      420

ctcagagtgg tgctcaagac actatggaaa caccagtttg catggccttt ccagcagcct      480

gtggatgccg tcaagctgaa cctccctgat tactataaga tcattaaaac gcctatggat      540

atgggaacaa taaagaagcg cttggaaaac aactattact ggaatgctca ggaatgtatc      600

caggacttca acactatgtt tacaaattgt tacatctaca acaagcctgg agatgacata      660

gtcttaatgg cagaagctct ggaaaagctc ttcttgcaaa aaataaatga gctacccaca      720

gaagaaaccg agatcatgat agtccaggca aaaggaagag gacgtgggag gaaagaaaca      780

gggacagcaa aacctggcgt ttccacggta ccaaacacaa ctcaagcatc gactcctccg      840

cagacccaga cccctcagcc gaatcctcct cctgtgcagg ccacgcctca ccccttccct      900

gccgtcaccc cggacctcat cgtccagacc cctgtcatga cagtggtgcc tccccagcca      960

ctgcagacgc ccccgccagt gcccccccag ccacaacccc cacccgctcc agctccccag     1020

cccgtacaga gccacccacc catcatcgcg gccaccccac agcctgtgaa gacaaagaag     1080

ggagtgaaga ggaaagcaga caccaccacc cccaccacca ttgaccccat tcacgagcca     1140

ccctcgctgc ccccggagcc caagaccacc aagctgggcc agcggcggga gagcagccgg     1200

cctgtgaaac ctccaaagaa ggacgtgccc gactctcagc agcacccagc accagagaag     1260

agcagcaagg tctcggagca gctcaagtgc tgcagcggca tcctcaagga gatgtttgcc     1320

aagaagcacg ccgcctacgc ctggcccttc tacaagcctg tggacgtgga ggcactgggc     1380

ctacacgact actgtgacat catcaagcac cccatggaca tgagcacaat caagtctaaa     1440

ctggaggccc gtgagtaccg tgatgctcag gagtttggtg ctgacgtccg attgatgttc     1500

tccaactgct ataagtacaa ccctcctgac catgaggtgg tggccatggc ccgcaagctc     1560

caggatgtgt tcgaaatgcg ctttgccaag atgccggacg agcctgagga gccagtggtg     1620

gccgtgtcct ccccggcagt gccccctccc accaaggttg tggccccgcc ctcatccagc     1680

gacagcagca gcgatagctc ctcggacagt gacagttcga ctgatgactc tgaggaggag     1740

cgagcccagc ggctggctga gctccaggag cagctcaaag ccgtgcacga gcagcttgca     1800

gccctctctc agccccagca gaacaaacca aagaaaaagg agaaagacaa gaaggaaaag     1860

aaaaaagaaa agcacaaaag gaaagaggaa gtggaagaga ataaaaaaag caaagccaag     1920

gaacctcctc ctaaaaagac gaagaaaaat aatagcagca acagcaatgt gagcaagaag     1980

gagccagcgc ccatgaagag caagccccct cccacgtatg agtcggagga agaggacaag     2040

tgcaagccta tgtcctatga ggagaagcgg cagctcagct tggacatcaa caagctcccc     2100

ggcgagaagc tgggccgcgt ggtgcacatc atccagtcac gggagccctc cctgaagaat     2160

tccaaccccg acgagattga aatcgacttt gagaccctga agccgtccac actgcgtgag     2220

ctggagcgct atgtcacctc ctgtttgcgg aagaaaagga aacctcaagc tgagaaagtt     2280

gatgtgattg ccggctcctc caagatgaag ggcttctcgt cctcagagtc ggagagctcc     2340

agtgagtcca gctcctctga cagcgaagac tccgaaacag agatggctcc gaagtcaaaa     2400

aagaaggggc accccgggag ggagcagaag aagcaccatc atcaccacca tcagcagatg     2460

cagcaggccc cggctcctgt gccccagcag ccgcccccgc ctccccagca gcccccaccg     2520

cctccacctc cgcagcagca acagcagccg ccacccccgc ctcccccacc ctccatgccg     2580

cagcaggcag ccccggcgat gaagtcctcg cccccaccct tcattgccac ccaggtgccc     2640

gtcctggagc cccagctccc aggcagcgtc tttgacccca tcggccactt cacccagccc     2700

atcctgcacc tgccgcagcc tgagctgccc cctcacctgc cccagccgcc tgagcacagc     2760

actccacccc atctcaacca gcacgcagtg gtctctcctc cagctttgca caacgcacta     2820

ccccagcagc catcacggcc cagcaaccga gccgctgccc tgcctcccaa gcccgcccgg     2880

cccccagccg tgtcaccagc cttgacccaa acacccctgc tcccacagcc ccccatggcc     2940

caaccccccc aagtgctgct ggaggatgaa gagccacctg ccccacccct cacctccatg     3000

cagatgcagc tgtacctgca gcagctgcag aaggtgcagc cccctacgcc gctactccct     3060

tccgtgaagg tgcagtccca gcccccaccc cccctgccgc ccccacccca cccctctgtg     3120

cagcagcagc tgcagcagca gccgccacca cccccaccac cccagcccca gcctccaccc     3180

cagcagcagc atcagccccc tccacggccc gtgcacttgc agcccatgca gttttccacc     3240

cacatccaac agcccccgcc accccagggc cagcagcccc cccatccgcc cccaggccag     3300

cagccacccc cgccgcagcc tgccaagcct cagcaagtca tccagcacca ccattcaccc     3360

cggcaccaca agtcggaccc ctactcaacc ggtcacctcc gcgaagcccc ctccccgctt     3420

atgatacatt ccccccagat gtcacagttc cagagcctga cccaccagtc tccaccccag     3480

caaaacgtcc agcctaagaa acaggagctg cgtgctgcct ccgtggtcca gccccagccc     3540

ctcgtggtgg tgaaggagga gaagatccac tcacccatca tccgcagcga gcccttcagc     3600

ccctcgctgc ggccggagcc ccccaagcac ccggagagca tcaaggcccc cgtccacctg     3660

ccccagcggc cggaaatgaa gcctgtggat gtcgggaggc ctgtgatccg gcccccagag     3720

cagaacgcac cgccaccagg ggcccctgac aaggacaaac agaaacagga gccgaagact     3780

ccagttgcgc ccaaaaagga cctgaaaatc aagaacatgg gctcctgggc cagcctagtg     3840

cagaagcatc cgaccacccc ctcctccaca gccaagtcat ccagcgacag cttcgagcag     3900

ttccgccgcg ccgctcggga gaaagaggag cgtgagaagg ccctgaaggc tcaggccgag     3960

cacgctgaga aggagaagga gcggctgcgg caggagcgca tgaggagccg agaggacgag     4020

gatgcgctgg agcaggcccg gcgggcccat gaggaggcac gtcggcgcca ggagcagcag     4080

cagcagcagc gccaggagca acagcagcag cagcaacagc aagcagctgc ggtggctgcc     4140

gccgccaccc cacaggccca gagctcccag ccccagtcca tgctggacca gcagagggag     4200

ttggcccgga agcgggagca ggagcgaaga cgccgggaag ccatggcagc taccattgac     4260

atgaatttcc agagtgatct attgtcaata tttgaagaaa atcttttctg agcgcaccta     4320

ggtggcttct gactttgatt ttctggcaaa acattgactt tccatagtgt taggggcggt     4380

ggtggaggtg ggatcagcgg ccaggggatg cctcagggcc tggccctcct gcatgctatg     4440

cccggggcag gcctgacggg cagctgagga ttgcagagcc tgtctgcctt acggccagtc     4500

ggacagacgt cccgccaccc accacccctc acaggacgtc cgctcagcac acgccttgtt     4560

acgagcaagt gccggctgga cccaagccct gcatccccac atgcggggca gaggcccttc     4620

tctccgccaa atgtctacac agtatacaca ggacatcgtt gctgccgccg tgactggttt     4680

tctgtcccca agaacgtgac gttcgtgatg tcctgcccgc cgggagtctt tccccacacc     4740

ccagccatcg ccgcccgctc ccaggaggcc agggcaggcc tgcgtgggct ggaggcgggc     4800

gaggccggcc caccccctcg ctggcactga ctttgccttg aacagacccc ccgaccctcc     4860

cccacaagcc tttaattgag agccgctctc tgtaagtgtt tgcttgtgca aaagggaata     4920

gtgccgtgga ggtgtgtgtg tccatggcat ccggagcgag gcgactgtcc tgcgtgggta     4980

gccctcggcc ggggagtgag gccaccaacc aaagtcagtt ccttcccacc tgtgtttctg     5040

tttcgttttt ttttttcttt tttttctata tatatttttt gttgaattct attttatttt     5100

taattctctc ttctcctcca gacacaatgg cactgcttat ctccgaaatg gtgtgatcgt     5160

ctcctcattg agcagcggct gccaccgcgc tgtgggta                             5198


<210> 10
<211> 1359
<212> PRT
<213> Homo sapiens

<400> 10
Met Ser Ala Glu Ser Gly Pro Gly Thr Arg Leu Arg Asn Leu Pro Val 
1               5                   10                  15      


Met Gly Asp Gly Leu Glu Thr Ser Gln Met Ser Thr Thr Gln Ala Gln 
            20                  25                  30          


Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Thr Asn Pro Pro Pro Pro 
        35                  40                  45              


Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln 
    50                  55                  60                  


Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala 
65                  70                  75                  80  


Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                  90                  95      


Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys 
            100                 105                 110         


Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp 
        115                 120                 125             


Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp 
    130                 135                 140                 


Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Arg 
145                 150                 155                 160 


Ile Asn Glu Leu Pro Thr Glu Glu Thr Glu Ile Met Ile Val Gln Ala 
                165                 170                 175     


Lys Gly Arg Gly Arg Gly Arg Lys Glu Thr Gly Thr Ala Lys Pro Gly 
            180                 185                 190         


Val Ser Thr Val Pro Asn Thr Thr Gln Ala Ser Thr Pro Pro Gln Thr 
        195                 200                 205             


Gln Thr Pro Gln Pro Asn Pro Pro Pro Val Gln Ala Thr Pro His Pro 
    210                 215                 220                 


Phe Pro Ala Val Thr Pro Asp Leu Ile Val Gln Thr Pro Val Met Thr 
225                 230                 235                 240 


Val Val Pro Pro Gln Pro Leu Gln Thr Pro Pro Pro Val Pro Pro Gln 
                245                 250                 255     


Pro Gln Pro Pro Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro 
            260                 265                 270         


Pro Ile Ile Ala Ala Thr Pro Gln Pro Val Lys Thr Arg Lys Gly Val 
        275                 280                 285             


Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ile Asp Pro Ile His 
    290                 295                 300                 


Glu Pro Pro Ser Leu Pro Pro Glu Pro Lys Thr Thr Lys Leu Gly Gln 
305                 310                 315                 320 


Arg Arg Glu Ser Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro 
                325                 330                 335     


Asp Ser Gln Gln His Pro Ala Pro Glu Arg Ser Ser Lys Val Ser Glu 
            340                 345                 350         


Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys 
        355                 360                 365             


His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala 
    370                 375                 380                 


Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met 
385                 390                 395                 400 


Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln 
                405                 410                 415     


Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr 
            420                 425                 430         


Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp Val 
        435                 440                 445             


Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro Val 
    450                 455                 460                 


Val Ala Val Ser Ser Pro Ala Val Pro Pro Pro Thr Lys Val Val Ala 
465                 470                 475                 480 


Pro Pro Ser Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser Asp 
                485                 490                 495     


Ser Ser Thr Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala Glu 
            500                 505                 510         


Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu Ser 
        515                 520                 525             


Gln Pro Gln Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys Glu 
    530                 535                 540                 


Lys Lys Lys Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn Lys 
545                 550                 555                 560 


Lys Ser Lys Ala Lys Glu Pro Pro Pro Lys Lys Thr Lys Lys Asn Asn 
                565                 570                 575     


Ser Ser Asn Ser Asn Val Ser Arg Lys Glu Pro Ala Pro Met Lys Ser 
            580                 585                 590         


Lys Pro Pro Pro Thr Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys Pro 
        595                 600                 605             


Met Ser Tyr Glu Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Leu Pro 
    610                 615                 620                 


Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro 
625                 630                 635                 640 


Ser Leu Lys Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr 
                645                 650                 655     


Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Thr Ser Cys 
            660                 665                 670         


Leu Arg Lys Lys Arg Lys Pro Gln Ala Glu Ile Cys Val Asp Val Ile 
        675                 680                 685             


Ala Gly Ser Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu Ser 
    690                 695                 700                 


Ser Ser Glu Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Thr Glu Met 
705                 710                 715                 720 


Ala Pro Lys Ser Lys Lys Lys Gly His Pro Gly Arg Glu Gln Lys Lys 
                725                 730                 735     


His His His His His His Gln Gln Met Gln Gln Ala Pro Ala Pro Val 
            740                 745                 750         


Pro Gln Gln Pro Pro Pro Pro Pro Gln Gln Pro Pro Pro Pro Pro Pro 
        755                 760                 765             


Pro Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Ser Met 
    770                 775                 780                 


Pro Gln Gln Ala Ala Pro Ala Met Lys Ser Ser Pro Pro Pro Phe Ile 
785                 790                 795                 800 


Ala Thr Gln Val Pro Val Leu Glu Pro Gln Leu Pro Gly Ser Val Phe 
                805                 810                 815     


Asp Pro Ile Gly His Phe Thr Gln Pro Ile Leu His Leu Pro Gln Pro 
            820                 825                 830         


Glu Leu Pro Pro His Leu Pro Gln Pro Pro Glu His Ser Thr Pro Pro 
        835                 840                 845             


His Leu Asn Gln His Ala Val Val Ser Pro Pro Ala Leu His Asn Ala 
    850                 855                 860                 


Leu Pro Gln Gln Pro Ser Arg Pro Ser Asn Arg Ala Ala Ala Leu Pro 
865                 870                 875                 880 


Pro Lys Pro Ala Arg Pro Pro Ala Val Ser Pro Ala Leu Thr Gln Thr 
                885                 890                 895     


Pro Leu Leu Pro Gln Pro Pro Met Ala Gln Pro Pro Gln Val Leu Leu 
            900                 905                 910         


Glu Asp Glu Glu Pro Pro Ala Pro Pro Leu Thr Ser Met Gln Met Gln 
        915                 920                 925             


Leu Tyr Leu Gln Gln Leu Gln Lys Val Gln Pro Pro Thr Pro Leu Leu 
    930                 935                 940                 


Pro Ser Val Lys Val Gln Ser Gln Pro Pro Pro Pro Leu Pro Pro Pro 
945                 950                 955                 960 


Pro His Pro Ser Val Gln Gln Gln Leu Gln Gln Gln Pro Pro Pro Pro 
                965                 970                 975     


Pro Pro Pro Gln Pro Gln Pro Pro Pro Gln Gln Gln His Gln Pro Pro 
            980                 985                 990         


Pro Arg Pro Val His Leu Gln Pro  Met Gln Phe Ser Thr  His Ile Gln 
        995                 1000                 1005             


Gln Pro  Pro Pro Pro Gln Gly  Gln Gln Pro Pro His  Pro Pro Pro 
    1010                 1015                 1020             


Gly Gln  Gln Pro Pro Pro Pro  Gln Pro Ala Lys Pro  Gln Gln Val 
    1025                 1030                 1035             


Ile Gln  His His His Ser Pro  Arg His His Lys Ser  Asp Pro Tyr 
    1040                 1045                 1050             


Ser Thr  Gly His Leu Arg Glu  Ala Pro Ser Pro Leu  Met Ile His 
    1055                 1060                 1065             


Ser Pro  Gln Met Ser Gln Phe  Gln Ser Leu Thr His  Gln Ser Pro 
    1070                 1075                 1080             


Pro Gln  Gln Asn Val Gln Pro  Lys Lys Gln Glu Leu  Arg Ala Ala 
    1085                 1090                 1095             


Ser Val  Val Gln Pro Gln Pro  Leu Trp Val Lys Glu  Glu Lys Ile 
    1100                 1105                 1110             


His Ser  Pro Ile Ile Arg Ser  Glu Pro Phe Ser Pro  Ser Leu Arg 
    1115                 1120                 1125             


Pro Glu  Pro Pro Lys His Pro  Glu Ser Ile Ala Pro  Val His Leu 
    1130                 1135                 1140             


Pro Gln  Arg Pro Glu Met Lys  Pro Val Asp Val Gly  Arg Pro Val 
    1145                 1150                 1155             


Ile Arg  Pro Pro Glu Gln Asn  Ala Pro Pro Pro Gly  Ala Pro Asp 
    1160                 1165                 1170             


Lys Asp  Lys Gln Lys Gln Glu  Pro Lys Thr Pro Val  Ala Pro Lys 
    1175                 1180                 1185             


Lys Asp  Leu Lys Ile Lys Asn  Met Gly Ser Trp Ala  Ser Leu Val 
    1190                 1195                 1200             


Gln Lys  His Pro Thr Thr Pro  Ser Ser Thr Ala Arg  Ser Ser Ser 
    1205                 1210                 1215             


Asp Ser  Phe Glu Gln Phe Arg  Arg Ala Ala Arg Glu  Lys Glu Glu 
    1220                 1225                 1230             


Arg Glu  Lys Ala Leu Lys Ala  Gln Ala Glu His Ala  Glu Lys Glu 
    1235                 1240                 1245             


Lys Glu  Arg Leu Arg Gln Glu  Arg Met Arg Ser Arg  Glu Asp Glu 
    1250                 1255                 1260             


Asp Ala  Leu Glu Gln Ala Arg  Arg Ala His Glu Glu  Ala Arg Arg 
    1265                 1270                 1275             


Arg Gln  Glu Gln Gln Gln Gln  Gln Arg Gln Glu Gln  Gln Gln Gln 
    1280                 1285                 1290             


Gln Gln  Gln Gln Ala Ala Ala  Val Ala Ala Ala Ala  Thr Pro Gln 
    1295                 1300                 1305             


Ala Gln  Ser Ser Gln Pro Gln  Ser Met Leu Asp Gln  Gln Arg Glu 
    1310                 1315                 1320             


Leu Ala  Arg Lys Arg Glu Gln  Glu Arg Arg Arg Arg  Glu Ala Met 
    1325                 1330                 1335             


Ala Ala  Thr Ile Asp Met Asn  Phe Gln Ser Asp Leu  Leu Ser Ile 
    1340                 1345                 1350             


Phe Glu  Glu Asn Leu Phe 
    1355                 


<210> 11
<211> 5673
<212> DNA
<213> Homo sapiens

<400> 11
tgccggggcc ggcgagccaa agaggagccg gccgcgcggg ccgggagggg acggccgccg       60

gagccgcgag gccaactgtc gcctggttgg gcccggaaat gggacgtcgc gctttctcag      120

ggagcgtaga agcagccagg gcctctccaa gccgctgctg tgacagaaag tgagtgagct      180

gccggaggat gtccaccgcc acgacagtcg cccccgcggg gatcccggcg accccgggcc      240

ctgtgaaccc accccccccg gaggtctcca accccagcaa gcccggccgc aagaccaacc      300

agctgcagta catgcagaat gtggtggtga agacgctctg gaaacaccag ttcgcctggc      360

ccttctacca gcccgtggac gcaatcaaat tgaacctgcc ggattatcat aaaataatta      420

aaaacccaat ggatatgggg actattaaga agagactaga aaataattat tattggagtg      480

caagcgaatg tatgcaggac ttcaacacca tgtttacaaa ttgttacatt tataacaagc      540

ccacagatga catagtgcta atggcccaag ctttagagaa aatttttcta caaaaagtgg      600

cccagatgcc ccaagaggaa gttgaattat taccccctgc tccaaagggc aaaggtcgga      660

agccggctgc gggagcccag agcgcaggta cacagcaagt ggcggccgtg tcctctgtct      720

ccccagcgac cccctttcag agcgtgcccc ccaccgtctc ccagacgccc gtcatcgctg      780

ccacccctgt accaaccatc actgcaaacg tcacgtcggt cccagtcccc ccagctgccg      840

ccccacctcc tcctgccaca cccatcgtcc ccgtggtccc tcctacgccg cctgtcgtca      900

agaaaaaggg cgtgaagcgg aaagcagaca caaccactcc cacgacgtcg gccatcactg      960

ccagccggag tgagtcgccc ccgccgttgt cagaccccaa gcaggccaaa gtggtggccc     1020

ggcgggagag tggtggccgc cccatcaagc ctcccaagaa ggacctggag gacggcgagg     1080

tgccccagca cgcaggcaag aagggcaagc tgtcggagca cctacgctac tgcgacagca     1140

tcctcaggga gatgctatcc aagaagcacg cggcctacgc ctggcccttc tacaagccag     1200

tggatgccga ggccctggag ctgcacgact accacgacat catcaagcac ccgatggacc     1260

tcagcaccgt gaaaaggaag atggatggcc gagagtaccc agacgcacag ggctttgctg     1320

ctgatgtccg gctgatgttc tcgaattgct acaaatacaa tcccccagac cacgaggttg     1380

tggccatggc ccggaagctc caggacgtgt ttgagatgag gtttgccaag atgccagatg     1440

agcccgtgga ggcaccggcg ctgcctgccc ccgcggcccc catggtgagc aagggcgctg     1500

agagcagccg tagcagtgag gagagctctt cggactcagg cagctcggac tcggaggagg     1560

agcgggccac caggctggcg gagctgcagg agcagctgaa ggccgtgcac gagcagctgg     1620

ccgccctgtc tcaggcccca gtaaacaaac caaagaagaa gaaggagaag aaggagaagg     1680

agaagaagaa gaaggacaag gagaaggaga aggagaagca caaagtgaag gccgaggaag     1740

agaagaaggc caaggtggct ccgcctgcca agcaggctca gcagaagaag gctcctgcca     1800

agaaggccaa cagcacgacc acggccggca gacagctgaa gaaaggcggc aagcaggcat     1860

ctgcctccta cgactcagag gaagaggagg agggcctgcc catgagctac gatgaaaagc     1920

gccagcttag cctggacatc aaccggctgc ccggggagaa gctgggccgg gtagtgcaca     1980

tcatccaatc tcgggagccc tcgctcaggg actccaaccc cgacgagata gaaattgact     2040

ttgagactct gaaacccacc actttgcggg aactggagag atatgtcaag tcttgtttac     2100

agaaaaagca aaggaaaccg ttctcagcaa gcgggaagaa acaggcagcc aagtcgaaag     2160

aggagctagc tcaggaaaag aagaaggagc tggaaaagcg tctgcaggat gtcagcgggc     2220

agctgagcag cagcaagaag cccgcccgga aagagaagcc cggctcagca ccctcagggg     2280

gcccgtccag gctcagcagc agcagctcct ccgagtctgg gagcagcagc tccagcgggt     2340

ccagctctga cagcagtgac tcagaatgaa ctggcttcgg acagaacagg acagatggat     2400

gtcgcacacg ccgagactct gccgtacccc tctgtggttc atattactac ttctgttcca     2460

tggtgtgcag gtctgcttct taattcagtg ttatgatatc ttccagtttt tgctttcata     2520

ggtcagagat ctatcttgtg tgtgcgttag acttgatgag aaggtgtgaa ctctgcagaa     2580

agtctcttct tcatcactga attcagtcac ttggagatga caacttcaaa tgctaacccg     2640

atgaccccag aaaaccgtgt gagattcgta ccgaagaacc ttgtggaatc cctttgctta     2700

ggcccaacct ggtcgatagc tcgagaaaga attttttcca aggaaatgtc tcggatatgg     2760

gtactgtatt tgaaagctgt tagctttgtc aacacgcatt gtccttgtca tttgggcccc     2820

gagctctgac cctcgtgtct gacgcggcca cctctttctg gaggggctga ggacagatgt     2880

gcctgcttgt ggagaccagg ctgggcctaa gcgaagggtc atcgcagccc cagcccggag     2940

cgtggagccc ttggggggtg gtcgggtggg atgtgcgttc tccgctcgtg gtgatgtcag     3000

gagctcctcg gagggaacag agcggctgtg tatgcagcct gcaggtttcc atacactgaa     3060

gcttttacct caactttaaa aaaaaaaaaa gaagaaaaga tttaaaaaaa aaaaaaaagg     3120

agactttttt tgtaaggttc ggcaattttc tacggaagtc cagcccgctg tgagtccccg     3180

cctggctagc gctgcccctg ctgctgctgc cgcgccaccc ttgggaacca cttcccgagc     3240

ttatgtgtat ataaatagtt atttattaac atcattggtc atttttaaaa aaaagaaaat     3300

aagaaaaaac cgcagaagaa atgcattcac acagtcgcag agatgcaggc cttgccagtg     3360

gtgtgccggg cgcgggtcct gtctggcggc ggcctgtcgt ctccaggtgc taactcctgc     3420

caccgcgcgg tgctcaccca cgtctgttcg cgcgctcgcc cctgggtttg ttgggttttt     3480

tggttttttt ctttgtggtt tttttttttt tttttttttg tatgaaactt ggaggcttac     3540

aggtatagac agctttcagc tacagcacat tctaattttt tattttgttt agttcttttg     3600

tattcacttc tggtctcttt aagactgttt taaaagaaat caatttaggg aaccccagtt     3660

atataatata aactttgtaa tctgagagaa aaaatgtata gtaaatctaa gtcttgattt     3720

ttaactttct attgtaaaaa ataataatat acagagttta atagaaggtg atgttttggt     3780

tttgttttcc cagaggctgc catatggtct ttgagtacgg ggatgtccca aactggccca     3840

ccaatgagca tggcggctcc ggccaggaat gccagagtta gcctcccagg cttgcgggtg     3900

gacatgcctg ctccctgcca gcctccagtg gcctggccag gccctcccga gcctgtctgc     3960

cctccccagg ggtggaggag tctctgggcc ccaggaggat tccctcccgg agactcgcac     4020

ggtgctccct gctcacgcgt tgtcacagtt agtccggaaa tgactgaaac caggcattct     4080

cccggacctc agcgtggggg agcctccagg cagacgctgg gtatggagct gtggtgtggt     4140

ctgtcctgta tggtggccag tgctttctgc cagcatttct ggatggatat agggactatc     4200

attagtatcc taatacacgg tgattttaaa acaaccataa aattgattca gagtccactg     4260

acccttacag atgtaggtat acccttactg gagagggaac tctgatgagg agatgctggt     4320

aaattatcat tttttaaatt gctggtgagt ctgacacttg gtgagttttc agccagtttg     4380

ttaaactttt aattaagttt tgtttataat aaaaatataa atggatttga aagtttccat     4440

tttttaaagt taccctcgtt ttcaaaggta ttttctaaac agatctttaa tggactattt     4500

aaaccgaatt taaggaattc acacacgaca gttgacaggt cttcacgcag gctggttggt     4560

aacgtgctgc cagcacaggg ctgggtgata cgtacaccct aagccggggg tgcctggggc     4620

tggggggcgc tccttgcaat gcccctccag ccacagggca gtgaggtgct gcctgtgtga     4680

gccgtcgggg gagcggccgg ctgtgggggc agcgcagcag gagcatcgtg gggcctttcc     4740

ttctcggctg gttctctgtg acggtggcgt cggctcgcct ctgctccttt catctagaaa     4800

gaagccactg accctgacag cccacggcgg gtacactgag cagctgcatt ggtgctgtca     4860

cttttttaag gctttctgtc cagacttcaa cactggtttc ttttcagagt ttcgaaggat     4920

taatgacttc ctcagcgccc ttgctggcgg gctgagggtg acagtcacgt ccgtttcttc     4980

tgtattagaa ggctgcggtg attcaattag attgtcccac tgctgagacc tgtagggcag     5040

cttctaacat gcttttttca aggggagagg agtagtgaca agtcgtgtgt cggaattgga     5100

tttgagaaca ctctgaatga cccctggagg ccgagggggc aggcttcggg cgtgaactga     5160

actccagacc cctctttgtg ttgggcagtg tcatcttgct tacaaactgt aagacacatt     5220

tttttgtgtg tttgtttttg ttgttgttct tttgcagcac tcacgcctct gacagtcttt     5280

tgggaaagag taacacccac atacagaatt tgtcacatcc agagtagcac tgttccttaa     5340

tactggcata atgcttccag gaagtttttc ttttttatat ttaaaatgtt acttttctgt     5400

atgatgtgca tgcaagttta ccgtaacttt tcttaaactt tttagtgccg tttctagtat     5460

attcctgtaa atgtcagtta ctgaaaatga gtccaatgta agtagtttag cttgtttatt     5520

gcaatgctgg cctcaacaca acagaataaa aatggtagaa agtactcttt gatgtttctg     5580

gtaatcatgg acccttctcc tggggcattt gttttgtttt cataataaaa agcaaaaaaa     5640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                  5673


<210> 12
<211> 725
<212> PRT
<213> Homo sapiens

<400> 12
Met Ser Thr Ala Thr Thr Val Ala Pro Ala Gly Ile Pro Ala Thr Pro 
1               5                   10                  15      


Gly Pro Val Asn Pro Pro Pro Pro Glu Val Ser Asn Pro Ser Lys Pro 
            20                  25                  30          


Gly Arg Lys Thr Asn Gln Leu Gln Tyr Met Gln Asn Val Val Val Lys 
        35                  40                  45              


Thr Leu Trp Lys His Gln Phe Ala Trp Pro Phe Tyr Gln Pro Val Asp 
    50                  55                  60                  


Ala Ile Lys Leu Asn Leu Pro Asp Tyr His Lys Ile Ile Lys Asn Pro 
65                  70                  75                  80  


Met Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Ser 
                85                  90                  95      


Ala Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr Asn Cys Tyr 
            100                 105                 110         


Ile Tyr Asn Lys Pro Thr Asp Asp Ile Val Leu Met Ala Gln Ala Leu 
        115                 120                 125             


Glu Lys Ile Phe Leu Gln Lys Val Ala Gln Met Pro Gln Glu Glu Val 
    130                 135                 140                 


Glu Leu Leu Pro Pro Ala Pro Lys Gly Lys Gly Arg Lys Pro Ala Ala 
145                 150                 155                 160 


Gly Ala Gln Ser Ala Gly Thr Gln Gln Val Ala Ala Val Ser Ser Val 
                165                 170                 175     


Ser Pro Ala Thr Pro Phe Gln Ser Val Pro Pro Thr Val Ser Gln Thr 
            180                 185                 190         


Pro Val Ile Ala Ala Thr Pro Val Pro Thr Ile Thr Ala Asn Val Thr 
        195                 200                 205             


Ser Val Pro Val Pro Pro Ala Ala Ala Pro Pro Pro Pro Ala Thr Pro 
    210                 215                 220                 


Ile Val Pro Val Val Pro Pro Thr Pro Pro Val Val Lys Lys Lys Gly 
225                 230                 235                 240 


Val Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ser Ala Ile Thr 
                245                 250                 255     


Ala Ser Arg Ser Glu Ser Pro Pro Pro Leu Ser Asp Pro Lys Gln Ala 
            260                 265                 270         


Lys Val Val Ala Arg Arg Glu Ser Gly Gly Arg Pro Ile Lys Pro Pro 
        275                 280                 285             


Lys Lys Asp Leu Glu Asp Gly Glu Val Pro Gln His Ala Gly Lys Lys 
    290                 295                 300                 


Gly Lys Leu Ser Glu His Leu Arg Tyr Cys Asp Ser Ile Leu Arg Glu 
305                 310                 315                 320 


Met Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro 
                325                 330                 335     


Val Asp Ala Glu Ala Leu Glu Leu His Asp Tyr His Asp Ile Ile Lys 
            340                 345                 350         


His Pro Met Asp Leu Ser Thr Val Lys Arg Lys Met Asp Gly Arg Glu 
        355                 360                 365             


Tyr Pro Asp Ala Gln Gly Phe Ala Ala Asp Val Arg Leu Met Phe Ser 
    370                 375                 380                 


Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met Ala 
385                 390                 395                 400 


Arg Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp 
                405                 410                 415     


Glu Pro Val Glu Ala Pro Ala Leu Pro Ala Pro Ala Ala Pro Met Val 
            420                 425                 430         


Ser Lys Gly Ala Glu Ser Ser Arg Ser Ser Glu Glu Ser Ser Ser Asp 
        435                 440                 445             


Ser Gly Ser Ser Asp Ser Glu Glu Glu Arg Ala Thr Arg Leu Ala Glu 
    450                 455                 460                 


Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu Ser 
465                 470                 475                 480 


Gln Ala Pro Val Asn Lys Pro Lys Lys Lys Lys Glu Lys Lys Glu Lys 
                485                 490                 495     


Glu Lys Lys Lys Lys Asp Lys Glu Lys Glu Lys Glu Lys His Lys Val 
            500                 505                 510         


Lys Ala Glu Glu Glu Lys Lys Ala Lys Val Ala Pro Pro Ala Lys Gln 
        515                 520                 525             


Ala Gln Gln Lys Lys Ala Pro Ala Lys Lys Ala Asn Ser Thr Thr Thr 
    530                 535                 540                 


Ala Gly Arg Gln Leu Lys Lys Gly Gly Lys Gln Ala Ser Ala Ser Tyr 
545                 550                 555                 560 


Asp Ser Glu Glu Glu Glu Glu Gly Leu Pro Met Ser Tyr Asp Glu Lys 
                565                 570                 575     


Arg Gln Leu Ser Leu Asp Ile Asn Arg Leu Pro Gly Glu Lys Leu Gly 
            580                 585                 590         


Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu Arg Asp Ser 
        595                 600                 605             


Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys Pro Thr Thr 
    610                 615                 620                 


Leu Arg Glu Leu Glu Arg Tyr Val Lys Ser Cys Leu Gln Lys Lys Gln 
625                 630                 635                 640 


Arg Lys Pro Phe Ser Ala Ser Gly Lys Lys Gln Ala Ala Lys Ser Lys 
                645                 650                 655     


Glu Glu Leu Ala Gln Glu Lys Lys Lys Glu Leu Glu Lys Arg Leu Gln 
            660                 665                 670         


Asp Val Ser Gly Gln Leu Ser Ser Ser Lys Lys Pro Ala Arg Lys Glu 
        675                 680                 685             


Lys Pro Gly Ser Ala Pro Ser Gly Gly Pro Ser Arg Leu Ser Ser Ser 
    690                 695                 700                 


Ser Ser Ser Glu Ser Gly Ser Ser Ser Ser Ser Gly Ser Ser Ser Asp 
705                 710                 715                 720 


Ser Ser Asp Ser Glu 
                725 


<210> 13
<211> 4
<212> PRT
<213> Homo sapiens

<400> 13
Pro Trp Trp Pro 
1               


<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
aagagccacc gcctgttaaa                                                   20


<210> 15
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
cuguaaaccu cuaaagaaau u                                                 21


<210> 16
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
gaaaggugcc agcgagauuu u                                                 21


<210> 17
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
gaacgugcuc agugggaua                                                    19


<210> 18
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
gcuugagguu cauacuaaa                                                    19


<210> 19
<211> 29
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: GALA 
      peptide

<400> 19
Ala Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15      


Leu Glu Ala Leu Ala Glu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  


<210> 20
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: EALA 
      peptode

<400> 20
Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala 
1               5                   10                  15      


Glu Ala Leu Ala Glu Ala Leu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  30  


<210> 21
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15  


<210> 22
<211> 22
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: INF-7
      peptide

<400> 22
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Trp Asp Tyr Gly 
            20          


<210> 23
<211> 23
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Inf HA-2
      peptide

<400> 23
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly 
            20              


<210> 24
<211> 48
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: diINF-7
      peptide

<400> 24
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Cys Gly Leu Phe Glu Ala Ile Glu Gly 
            20                  25                  30          


Phe Ile Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Trp Tyr Gly Cys 
        35                  40                  45              


<210> 25
<211> 44
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: diINF-3
      peptide

<400> 25
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Gly Cys Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile 
            20                  25                  30          


Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Gly Cys 
        35                  40                  


<210> 26
<211> 35
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: GLF 
      peptide

<400> 26
Gly Leu Phe Gly Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu 
1               5                   10                  15      


His Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly 
            20                  25                  30          


Gly Ser Cys 
        35  


<210> 27
<211> 34
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: GALA-INF3
      peptide

<400> 27
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly Gly 
            20                  25                  30          


Ser Cys 
        


<210> 28
<211> 41
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: INF-5 
      peptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Norleucine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Norleucine

<400> 28
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ile Asp Gly Lys Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu 
            20                  25                  30          


Asn Gly Trp Glu Gly Leu Ile Asp Gly 
        35                  40      


<210> 29
<211> 19
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: JTS-1
      peptide

<400> 29
Leu Phe Glu Ala Leu Leu Glu Leu Leu Glu Ser Leu Trp Glu Leu Leu 
1               5                   10                  15      


Leu Glu Ala 
            


<210> 30
<211> 20
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: ppTG1 
      peptide

<400> 30
Gly Leu Phe Lys Ala Leu Leu Lys Leu Leu Lys Ser Leu Trp Lys Leu 
1               5                   10                  15      


Leu Leu Lys Ala 
            20  


<210> 31
<211> 20
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: ppTG20 
      peptide

<400> 31
Gly Leu Phe Arg Ala Leu Leu Arg Leu Leu Arg Ser Leu Trp Arg Leu 
1               5                   10                  15      


Leu Leu Arg Ala 
            20  


<210> 32
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: KALA 
      peptide

<400> 32
Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu Ala 
            20                  25                  30  


<210> 33
<211> 22
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: HA 
      peptide

<400> 33
Gly Leu Phe Phe Glu Ala Ile Ala Glu Phe Ile Glu Gly Gly Trp Glu 
1               5                   10                  15      


Gly Leu Ile Glu Gly Cys 
            20          


<210> 34
<211> 26
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Melittin 
      peptide

<400> 34
Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210> 35
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
His His His His His Trp Tyr Gly 
1               5               


<210> 36
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Cys His Lys Lys Lys Lys Lys Lys His Cys 
1               5                   10  


<210> 37
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: penetratin 
      peptide

<400> 37
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 38
<211> 14
<212> PRT
<213> Human immunodeficiency virus

<400> 38
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Cys 
1               5                   10                  


<210> 39
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: signal 
      sequence based peptide

<400> 39
Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210> 40
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: PVEC 
      peptide

<400> 40
Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210> 41
<211> 26
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: transportan 
      peptide

<400> 41
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Lys Ile Asn Leu Lys 
1               5                   10                  15      


Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25      


<210> 42
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: amphiphilic 
      model peptide

<400> 42
Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210> 43
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 44
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: bacterial 
      cell wall permeating peptide

<400> 44
Lys Phe Phe Lys Phe Phe Lys Phe Phe Lys 
1               5                   10  


<210> 45
<211> 37
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: LL-37 
      peptide

<400> 45
Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210> 46
<211> 31
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: cecropin 
      P1 peptide

<400> 46
Ser Trp Leu Ser Lys Thr Ala Lys Lys Leu Glu Asn Ser Ala Lys Lys 
1               5                   10                  15      


Arg Ile Ser Glu Gly Ile Ala Ile Ala Ile Gln Gly Gly Pro Arg 
            20                  25                  30      


<210> 47
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: alpha-defensin 
      peptide

<400> 47
Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
1               5                   10                  15      


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  30  


<210> 48
<211> 36
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: beta-defensin 
      peptide

<400> 48
Asp His Tyr Asn Cys Val Ser Ser Gly Gly Gln Cys Leu Tyr Ser Ala 
1               5                   10                  15      


Cys Pro Ile Phe Thr Lys Ile Gln Gly Thr Cys Tyr Arg Gly Lys Ala 
            20                  25                  30          


Lys Cys Cys Lys 
        35      


<210> 49
<211> 42
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: PR-39
      peptide


<220>
<223> C-term NH2

<400> 49
Arg Arg Arg Pro Arg Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro Pro 
1               5                   10                  15      


Phe Phe Pro Pro Arg Leu Pro Pro Arg Ile Pro Pro Gly Phe Pro Pro 
            20                  25                  30          


Arg Phe Pro Pro Arg Phe Pro Gly Lys Arg 
        35                  40          


<210> 50
<211> 13
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: indolicidin 
      peptide


<220>
<223> C-term NH2

<400> 50
Ile Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210> 51
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: RFGF 
      peptide

<400> 51
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 52
<211> 11
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: RFGF 
      analogue peptide

<400> 52
Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210> 53
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: bactenecin 
      peptide

<400> 53
Arg Lys Cys Arg Ile Val Val Ile Arg Val Cys Arg 
1               5                   10          


<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 54
gctgtcacaa atggaggtgc                                                   20


<210> 55
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 55
tcaagtgggg cgatgctggc gct                                               23


<210> 56
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 56
agggggccct ccgacgcctg ct                                                22


<210> 57
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 57
aaacucagaa cuuuauccuu auu                                               23


<210> 58
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 58
uuaccuuugg aaggagcua                                                    19


<210> 59
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 59
gggagaaaga ggagcgugau u                                                 21


<210> 60
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 60
gguauaggau uuugaagca                                                    19


<210> 61
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 61
ggauaacgau ggcuacua                                                     18


<210> 62
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 62
guaaugaucg accgaaugu                                                    19


<210> 63
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 63
ccaccacguu caaugggaa                                                    19


<210> 64
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
uagcagaaau guacaacua                                                    19


<210> 65
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 65
gcgcaauaau guauacuuu                                                    19


<210> 66
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 66
ttctaggagt gcggccaaag                                                   20


<210> 67
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 67
cagctctcca ccatctccac                                                   20


<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 68
gccccagttc agccaatact                                                   20


<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 69
accatacaag gccaccaagg                                                   20


<210> 70
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 70
cctggaggag aagaggaaag aga                                               23


<210> 71
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 71
ttgaggacct ctgtgtattt gtcaa                                             25


<210> 72
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 72
ccaacgcaga gtgtatcatc tcctgaagca acatctggtt ctacagcatc                  50


<210> 73
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 73
caacgcagag tgtaccatct cctgaagcaa catctggttc tacagcatct                  50


<210> 74
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 74
caacgcagag tgtatcatct cctgaagcaa catctggttc tacagcatct                  50


<210> 75
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 75
caacgcagag tgtatcatct cctgaagcaa catctggttc tacagcgtct                  50


<210> 76
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 76
aacgcagagt gtatcatctc ctgaagcaac atctggttct acagcatctg                  50


<210> 77
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 77
ctcgcagagt gtatcatctc ctgaagcaac atctggttct acagcatctg                  50


<210> 78
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
acgcagagtg tatcatctcc tgaagcaaca tctggttcta cagcatctgc                  50


<210> 79
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 79
cgcagagtgt attatctcct gaagcaacat ctggttctac agcatctgca                  50


<210> 80
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
cgcagagtgt atcatctcct gaagcaacat ctggttctac agcatctgag                  50


<210> 81
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 81
cgcagagtgt atcatctcct gaagcaacat ctggttctac agcatctgca                  50


<210> 82
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 82
gcagagtgta tcatctcctg aagcaacatc tggttctaca gcatctgcat                  50


<210> 83
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 83
cagagtgtat catctcctga agcaacatct ggttctacag catctgcatt                  50


<210> 84
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 84
agagtgtatc atctcctgaa gcaacatctg gttctacagc atctgcattg                  50


<210> 85
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 85
tgagtgtatc atctcctgaa gcaacatctg gttctacagc atctgcattg                  50


<210> 86
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 86
gagtgtatca tctcctgaag caacatctgg ttctacagca tctgcattgc                  50


<210> 87
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
agtgtatcat ctcctgaagc aacatctggt tctacagcat ctgcattgcc                  50


<210> 88
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 88
gtgtatcatc tcctgaagca acatctggtt ctacagcatc tgcattgccg                  50


<210> 89
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 89
tgtatcatct cctgaagcaa catctggttc tacagcatct gcattgccgg                  50


<210> 90
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 90
tattatctcc tgaagcaaca tctggttcta cagcatctgc attgccggga                  50


<210> 91
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 91
tatcatctcc tgaagcaaca tctggttcta cagcatctgc attgccggga                  50


<210> 92
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 92
atcatctcct gaagcaacat ctggttctac agcatctgca ttgccgggac                  50


<210> 93
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 93
tcatctcctg aagcaacatc tggttctaca gcatctgcat tgccgggacc                  50


<210> 94
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 94
catctcctga agcaacatct ggttctacag catctgcatt gccgggaccg                  50


<210> 95
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 95
atctcctgaa gcaacatctg gttctacagc atctgcattg ccgggaccgg                  50


<210> 96
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 96
tctcctgaag caacatctgg ttctacagca tctgcattgc cgggaccgga                  50


<210> 97
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 97
ctcctgaagc aacatctggt tctacagcat ctgcattgcc gggaccggat                  50


<210> 98
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 98
tcctgaagca acatctggtt ctacagcatc tgcattgccg ggaccggata                  50


<210> 99
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 99
ctgaagcaac atctggttct acagcatctg cattgccggg accggatatg                  50


<210> 100
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 100
tgaagcaaca tctggttcta cagcatctgc attgccggga ccggatatga                  50


<210> 101
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 101
gaagcaacat ctggttctac agcatctgca ttgccgggac cggatatgag                  50


<210> 102
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 102
aagcaacatc tggttctaca gcatctgcat tgccgggacc ggatatgagc                  50


<210> 103
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 103
agcaacatct ggttctacag catctgcatt gccgggaccg gatatgagca                  50


<210> 104
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 104
gcaacatctg gttctacagc atctgcattg ccgggaccgg atatgagcat                  50


<210> 105
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 105
caacatctgg ttctacagca tctgcattgc cgggaccgga tatgagcatg                  50


<210> 106
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 106
aacatctggt tctacagcat ctgcattgcc gggaccggat atgagcatga                  50


<210> 107
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 107
acatctggtt ctacagcatc tgcattgccg ggaccggata tgagcatgaa                  50


<210> 108
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 108
atctggttct acagcatctg cattgccggg accggatatg agcatgaaac                  50


<210> 109
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 109
tctggttcta cagcatctgc attgccggga ccggatatga gcatgaaacc                  50


<210> 110
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 110
ctggttctac agcatctgca ttgccgggac cggatatgag catgaaacct                  50


<210> 111
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 111
tggttctaca gcatctgcat tgccgggacc ggatatgagc atgaaaccta                  50


<210> 112
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 112
ggttctacag catctgcatt gccgggaccg gatatgagca tgaaacctag                  50


<210> 113
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 113
gttctacagc atctgcattg ccgggaccgg atatgagcat gaaacctagt                  50


