                               SEQUENCE LISTING

<110> CHURCH, WILLIAM R.
 
<120> ANTIBODY SPECIFIC TO STAPHYLOCOCCUS AUREUS, THERAPEUTIC METHOD AND
      DETECTION METHOD USING SAME

<130> 163-303

<140>
<141>

<150> 61/931,236
<151> 2014-01-24

<160> 27    

<170> PatentIn version 3.5

<210> 1
<211> 2067
<212> DNA
<213> Staphylococcus aureus

<400> 1
atagtaacaa aggattatag caaagagtca agagtgaatg agaacagtaa atatgggaca       60

ttaatttcag actggtattt aaaagggaga ttaactagtc tagaatctca atttatcaat      120

gcattggata ttttagagac atatcattat ggcgaaaaag agtataaaga tgcaaaagat      180

aaattgatga caagaatttt aggggaagac caataccttt tagaaagaaa aaaagtgcag      240

tatgaggaat acaaaaaatt ataccaaaaa tataaagaag agaatccaac ctctaaagtt      300

aaaatgaaaa cattcgatca atatacaata gaagatttaa ctatgaggga atataatgag      360

ttaacagaat cattaaaaag tgctgtaaaa gactttgaga aagatgttga aaaaatagaa      420

aatcaacatc atgatttgaa accatttact gatgaaatgg aagagaaggc tacttctaga      480

gttgatgatt tagcaaataa agcatatagt gtttattttg catttgttag ggatacacaa      540

cataaaactg aggcattaga gttaaaagcg aaagtagatt tagttttagg tgatgaggat      600

aaaccgcatc gtatttctaa tgaaagaatt gaaaaagaaa tgataaaaga tttagaatct      660

attattgaag atttctttat agaaactggt ttaaataagc ctggtaatat tacgagttat      720

gatagtagta aacatcacta taaaaatcac agtgaaggtt ttgaggctct agtcaaagaa      780

acaagagaag cagtagcaaa cgctgacgaa tcttggaaaa ctaaaactgt aaaaaaatac      840

ggtgaatctg aaacaaaatc tcctgttgta aaagaagaga acaaagttga agaccctcaa      900

tcacctaaat ttgataacca acaagaggtt aaaactacgg ctggtaaagc tgaagaaaca      960

acacaaccag ttgcacaacc attagttaaa attccacagg gcacaattac aggtgaaatt     1020

gtgaaaggtc cggaatatcc aacgatggaa aataaaacgt tacaaggtga aatcgttcaa     1080

ggtccagatt tcccaacaat ggaacaaagc ggtccatctt taagcgacaa ttatactcaa     1140

ccgacgacac cgaaccctat tttagaaggt cttgaaggta gctcatctaa acttgaaata     1200

aaaccacaag gtactgaatc aacgttgaaa ggtattcaag gagaatcaag tgatattgaa     1260

gttaaacctc aagcaactga aacaacagaa gcttctcaat atggtccgag accgcaattt     1320

aacaaaacac ctaagtatgt gaaatataga gatgctggta caggtattcg tgaatacaac     1380

gatggaacat ttggatatga agcgagacca agattcaaca agccatcaga aacaaacgca     1440

tacaacgtaa cgacaaatca agatggcaca gtatcatacg gcgcccgccc aacacaaaac     1500

aaggcatcag aaacaaacgc atataacgta acaacacatg caaacggcca agtatcatac     1560

ggagctcgcc caacacaaaa gaagccaagc gaaacaaatg catataacgt aacaacacat     1620

gcaaacggcc aagtatcata tggcgcccgc ccgacataca acaagccaag cgaaacaaat     1680

gcatataacg taacaacaca cggaaatggc caagtatcat atggagctcg tccgacatac     1740

aagaaaccaa gtaaaacaaa tgcatataac gtaacaacac atgcaaacgg ccaagtgtca     1800

tacggagctc gcccaacaca aaagaagcca agcgaaacaa acgcatataa cgtaacaaca     1860

catgcaaatg gccaagtatc atacggagct cgcccaacac aaaagaagcc aagcgaaaca     1920

aacgcatata acgtaacaac acacggaaac ggtcaagtgt catacggcgc tcgtccgaca     1980

tacaacaagc caagtaaaac aaatgcatac aatgtaacaa cacatgcaga tggtactgcg     2040

acatatggtc ctagagtaac aaaataa                                         2067


<210> 2
<211> 689
<212> PRT
<213> Staphylococcus aureus

<400> 2
Ile Val Thr Lys Asp Tyr Ser Lys Glu Ser Arg Val Asn Glu Asn Ser 
1               5                   10                  15      


Lys Tyr Gly Thr Leu Ile Ser Asp Trp Tyr Leu Lys Gly Arg Leu Thr 
            20                  25                  30          


Ser Leu Glu Ser Gln Phe Ile Asn Ala Leu Asp Ile Leu Glu Thr Tyr 
        35                  40                  45              


His Tyr Gly Glu Lys Glu Tyr Lys Asp Ala Lys Asp Lys Leu Met Thr 
    50                  55                  60                  


Arg Ile Leu Gly Glu Asp Gln Tyr Leu Leu Glu Arg Lys Lys Val Gln 
65                  70                  75                  80  


Tyr Glu Glu Tyr Lys Lys Leu Tyr Gln Lys Tyr Lys Glu Glu Asn Pro 
                85                  90                  95      


Thr Ser Lys Gly Leu Lys Leu Lys Thr Phe Asp Gln Tyr Thr Ile Glu 
            100                 105                 110         


Asp Leu Thr Met Arg Glu Tyr Asn Glu Leu Thr Glu Ser Leu Lys Ser 
        115                 120                 125             


Ala Val Lys Asp Phe Glu Lys Asp Val Glu Lys Ile Glu Asn Gln His 
    130                 135                 140                 


His Asp Leu Lys Pro Phe Thr Asp Glu Met Glu Glu Lys Ala Thr Ser 
145                 150                 155                 160 


Arg Val Asp Asp Leu Ala Asn Lys Ala Tyr Ser Val Tyr Phe Ala Phe 
                165                 170                 175     


Val Arg Asp Thr Gln His Lys Thr Glu Ala Leu Glu Leu Lys Ala Lys 
            180                 185                 190         


Val Asp Leu Val Leu Gly Asp Glu Asp Lys Pro His Arg Ile Ser Asn 
        195                 200                 205             


Glu Arg Ile Glu Lys Glu Met Ile Lys Asp Leu Glu Ser Ile Ile Glu 
    210                 215                 220                 


Asp Phe Phe Ile Glu Thr Gly Leu Asn Lys Pro Gly Asn Ile Thr Ser 
225                 230                 235                 240 


Tyr Asp Ser Ser Lys His His Tyr Lys Asn His Ser Glu Gly Phe Glu 
                245                 250                 255     


Ala Leu Val Lys Glu Thr Arg Glu Ala Val Ala Asn Ala Asp Glu Ser 
            260                 265                 270         


Trp Lys Thr Lys Thr Val Lys Lys Tyr Gly Glu Ser Glu Thr Lys Ser 
        275                 280                 285             


Pro Val Val Lys Glu Glu Asn Lys Val Glu Asp Pro Gln Ser Pro Lys 
    290                 295                 300                 


Phe Asp Asn Gln Gln Glu Val Lys Thr Thr Ala Gly Lys Ala Glu Glu 
305                 310                 315                 320 


Thr Thr Gln Pro Val Ala Gln Pro Leu Val Lys Ile Pro Gln Gly Thr 
                325                 330                 335     


Ile Thr Gly Glu Ile Val Lys Gly Pro Glu Tyr Pro Thr Met Glu Asn 
            340                 345                 350         


Lys Thr Leu Gln Gly Glu Ile Val Gln Gly Pro Asp Phe Pro Thr Met 
        355                 360                 365             


Glu Gln Ser Gly Pro Ser Leu Ser Asp Asn Tyr Thr Gln Pro Thr Thr 
    370                 375                 380                 


Pro Asn Pro Ile Leu Glu Gly Leu Glu Gly Ser Ser Ser Lys Leu Glu 
385                 390                 395                 400 


Ile Lys Pro Gln Gly Thr Glu Ser Thr Leu Lys Gly Ile Gln Gly Glu 
                405                 410                 415     


Ser Ser Asp Ile Glu Val Lys Pro Gln Ala Thr Glu Thr Thr Glu Ala 
            420                 425                 430         


Ser Gln Tyr Gly Pro Arg Pro Gln Phe Asn Lys Thr Pro Lys Tyr Val 
        435                 440                 445             


Lys Tyr Arg Asp Ala Gly Thr Gly Ile Arg Glu Tyr Asn Asp Gly Thr 
    450                 455                 460                 


Phe Gly Tyr Glu Ala Arg Pro Arg Phe Asn Lys Pro Ser Glu Thr Asn 
465                 470                 475                 480 


Ala Tyr Asn Val Thr Thr Asn Gln Asp Gly Thr Val Ser Tyr Gly Ala 
                485                 490                 495     


Arg Pro Thr Gln Asn Lys Ala Ser Glu Thr Asn Ala Tyr Asn Val Thr 
            500                 505                 510         


Thr His Ala Asn Gly Gln Val Ser Tyr Gly Ala Arg Pro Thr Gln Lys 
        515                 520                 525             


Lys Pro Ser Glu Thr Asn Ala Tyr Asn Val Thr Thr His Ala Asn Gly 
    530                 535                 540                 


Gln Val Ser Tyr Gly Ala Arg Pro Thr Tyr Asn Lys Pro Ser Glu Thr 
545                 550                 555                 560 


Asn Ala Tyr Asn Val Thr Thr His Gly Asn Gly Gln Val Ser Tyr Gly 
                565                 570                 575     


Ala Arg Pro Thr Tyr Lys Lys Pro Ser Lys Thr Asn Ala Tyr Asn Val 
            580                 585                 590         


Thr Thr His Ala Asn Gly Gln Val Ser Tyr Gly Ala Arg Pro Thr Gln 
        595                 600                 605             


Asn Lys Pro Ser Glu Thr Asn Ala Tyr Asn Val Thr Thr His Ala Asn 
    610                 615                 620                 


Gly Gln Val Ser Tyr Gly Ala Arg Pro Thr Gln Asn Lys Pro Ser Glu 
625                 630                 635                 640 


Thr Asn Ala Tyr Asn Val Thr Thr His Gly Asn Gly Gln Val Ser Tyr 
                645                 650                 655     


Gly Ala Arg Pro Thr Tyr Asn Lys Pro Ser Lys Thr Asn Ala Tyr Asn 
            660                 665                 670         


Val Thr Thr His Ala Asp Gly Thr Ala Thr Tyr Gly Pro Arg Val Thr 
        675                 680                 685             


Lys 
    


<210> 3
<211> 873
<212> DNA
<213> Staphylococcus aureus

<400> 3
gtagtaccag aaacaggtat taataaaata attccagatt atgataaata taagaatgca       60

ctaaagctaa atgtgagtag tttaactaac aacaataact ttgtagcttc tgaagataaa      120

ttgaaaaaaa ttgcagatcc atcagcagct ggtaaaattg taggtggaaa atttgccgta      180

ctagaatcaa agttaggaag tattgtacca gagtacaaag aaataaataa acgtgcgaat      240

gtaacaggaa acaacaatcc cagtcataat attggaaagt cttttgttac taaaggtcca      300

gaagtaaaaa gatttattac acaaaacaaa gtaaaatacc acttcattac tacacaaaca      360

cactacaaga aagaagttac ttcattcaaa tcaacgcatg tacataaata tataaatcat      420

gcaactactt ctagcaataa acattttact gttaaaccaa tagaagcgcc tagatataaa      480

cacccatctc aatctttaat tataaatcat catattgcag tacctggcta ccatgctcat      540

aaatttgtaa caccaggaca tgctagtatt aaaattcatc atttttgtat tgcaccaaaa      600

ataaatagtt ttaaagtaat tccatcatat ggtcacagtt cacaccgcat gcatgtacca      660

agttttcaaa gtaatacaaa atcagtacat caaaattcta gagtaaataa agtatataac      720

tataaatact tctactctta taaagtagtg aaaggtgtga agaaatatta ctcattttca      780

aaatcaaatg cttataaatt tgttaaacca ccatttaata tcaaaaatgt aaattaccaa      840

tatgctgctt taagtaatag ccctacacac taa                                   873


<210> 4
<211> 481
<212> PRT
<213> Staphylococcus aureus

<400> 4
Val Val Ser Gly Glu Glu Asn Pro Tyr Val Ser Lys Ala Ile Glu Leu 
1               5                   10                  15      


Lys Gly Thr Ser Asn Lys Ser Asn Thr Tyr Glu Asn Tyr Arg Glu Ser 
            20                  25                  30          


Leu Glu Asn Leu Ile Phe Ser Leu Ser Phe Ala Asp Tyr Glu Lys Tyr 
        35                  40                  45              


Glu Glu Pro Glu Tyr Asn Asn Ala Val Lys Lys Tyr Gln Gln Lys Phe 
    50                  55                  60                  


Met Ala Glu Asp Asp Ala Leu Lys Thr Phe Leu Ser Glu Glu Lys Lys 
65                  70                  75                  80  


Leu Glu Lys Thr Asp Arg Ser Arg Asn Ser Asn Gly Leu Leu Gly Leu 
                85                  90                  95      


Thr His Glu Arg Tyr Thr Tyr Ile Phe Asp Thr Leu Lys Lys Asn Lys 
            100                 105                 110         


Gln Glu Phe Leu Gln Glu Ile Glu Glu Ile Asn Leu Lys Asn Ser Asp 
        115                 120                 125             


Leu Lys Asp Phe Asn Asp Thr Glu Gln Tyr Asn Ala Asp Val Glu Ile 
    130                 135                 140                 


Asn Asn Leu Glu Asn Lys Val Leu Met Leu Gly Tyr Thr Phe Phe Ser 
145                 150                 155                 160 


Thr Tyr Lys Asp Glu Val Glu Glu Leu Tyr Ser Glu Leu Asp Leu Ile 
                165                 170                 175     


Val Gly Glu Val Gln Asp Lys Ser Asp Lys Lys Arg Ala Val Asn Gln 
            180                 185                 190         


Arg Met Leu Ser Arg Lys Lys Glu Asp Leu Glu Ser Ile Ile Asp Lys 
        195                 200                 205             


Phe Phe Lys Glu Ile Lys Gln Glu Arg Pro Glu Asn Ile Pro Ala Leu 
    210                 215                 220                 


Thr Ser Asp Lys Asn His Asn Gln Ser Met Ala Leu Lys Leu Lys Ser 
225                 230                 235                 240 


Asp Thr Glu Ala Ala Lys Lys Asp Glu Ser Asn Arg Ser Ser Arg Ser 
                245                 250                 255     


Lys Lys Ser Leu Asp Ser Gln Asn Tyr Lys Ser Val Ser Gln Glu Val 
            260                 265                 270         


Thr Ala Glu Gln Lys Ala Glu Tyr Glu Lys Arg Ala Glu Glu Arg Lys 
        275                 280                 285             


Ala Arg Phe Leu Asp Arg Gln Lys Ser Lys Lys Glu Pro Val Val Ser 
    290                 295                 300                 


Leu Glu Tyr Asp Phe Glu His Lys Gln Ser Val Asp Asn Glu Asn Asp 
305                 310                 315                 320 


Lys Gln Leu Val Val Ser Glu Pro Thr Lys Asn Pro Thr Leu Pro Thr 
                325                 330                 335     


Tyr Ile Glu Thr Thr Thr Gln Val Pro Met Pro Thr Val Glu Arg Gln 
            340                 345                 350         


Thr Gln Gln Gln Ile Ile Tyr Lys Ala Pro Lys Gln Leu Ala Gly Leu 
        355                 360                 365             


Asn Gly Glu Ser His Asp Phe Ser Thr Thr His Gln Thr Pro Thr Thr 
    370                 375                 380                 


Ser Asn His Thr His Asn Asn Val Val Glu Phe Glu Glu Thr Ser Ala 
385                 390                 395                 400 


Leu Pro Gly Arg Lys Thr Gly Ser Leu Val Gly Leu Ser Gln Ile Asp 
                405                 410                 415     


Ser Ser His Leu Thr Glu Arg Glu Lys Arg Val Ile Lys Arg Glu His 
            420                 425                 430         


Val Arg Glu Ala Gln Lys Leu Val Glu Asn Tyr Lys Asp Thr His Ser 
        435                 440                 445             


Tyr Lys Asp Arg Leu Asn Ala Gln Gln Lys Val Asn Thr Leu Ser Glu 
    450                 455                 460                 


Gly His Gln Lys Arg Phe Asn Lys Gln Ile Asn Lys Val Tyr Asn Gly 
465                 470                 475                 480 


Lys 
    


<210> 5
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region polynucleotide

<400> 5
gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc       60

tcttgtgctg cctctggatt cacttttagt gacgcctgga tggactgggt ccgccagtct      120

ccagagaagg ggcttgagtg ggttgctgaa attagaacca aagctaataa tcatgcaaca      180

tactatgctg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagcagt      240

gtctacctgc aaatgaacag cttaagagct gaagacactg gcatttatta ctgtaccaac      300

gtctactatg gtaacaacga tgttaaggac tactggggtc aaggaacctc agtcaccgtc      360

tcccca                                                                 366


<210> 6
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region polypeptide

<400> 6
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Asn Val Tyr Tyr Gly Asn Asn Asp Val Lys Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Pro Ala Ser 
        115                 120                 


<210> 7
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region polynucleotide 

<400> 7
gatattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtggat atttatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggttcagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca gcatcagcaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcaa tataacaact atccgtatac gttcggaggg      300

gggaccaagc tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      360

tccagtgaag ggcgaatt                                                    378


<210> 8
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region polypeptide

<400> 8
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Ile Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Phe Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gly Arg Ile 
        115                 120                 125     


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Ile Val Thr Lys Asp Tyr Ser Lys Glu Ser 
1               5                   10  


<210> 10
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      CDRL1 peptide

<400> 10
Gln Asn Val Asp Ile Tyr 
1               5       


<210> 11
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      CDRL2 peptide

<400> 11
Ser Ala Ser 
1           


<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      CDRL3 peptide

<400> 12
Gln Gln Tyr Asn Asn Tyr Pro Tyr Thr 
1               5                   


<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      CDRH1 peptide

<400> 13
Gly Phe Thr Phe Ser Asp Ala Trp 
1               5               


<210> 14
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      CDRH2 peptide

<400> 14
Ile Arg Thr Lys Ala Asn Asn His Ala Thr 
1               5                   10  


<210> 15
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      CDRH3 peptide

<400> 15
Cys Thr Asn Val Tyr Tyr Gly Asn Asn Asp Val Lys Asp Tyr 
1               5                   10                  


<210> 16
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      humanized GMA-2105 Light chain variable region version 1
      polypeptide

<400> 16
Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala 
1               5                   10                  15      


Thr Ile Asn Cys Lys Ala Ser Gln Asn Val Asp Ile Tyr Val Ala Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Ala Leu Ile Tyr Ser Ala 
        35                  40                  45              


Ser Tyr Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
    50                  55                  60                  


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val 
65                  70                  75                  80  


Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Tyr Thr Phe Gly 
                85                  90                  95      


Gln Gly Thr Lys Val Glu 
            100         


<210> 17
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      humanized GMA-2105 Light chain variable region version 2
      polypeptide

<400> 17
Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala 
1               5                   10                  15      


Thr Ile Asn Cys Lys Ala Ser Gln Asn Val Asp Ile Tyr Val Ala Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala 
        35                  40                  45              


Ser Tyr Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
    50                  55                  60                  


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val 
65                  70                  75                  80  


Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Tyr Thr Phe Gly 
                85                  90                  95      


Gln Gly Thr Lys Val Glu 
            100         


<210> 18
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      humanized GMA-2105 Heavy chain variable region version 1
      polypeptide

<400> 18
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
1               5                   10                  15      


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala Trp Met Asp 
            20                  25                  30          


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Glu Ile 
        35                  40                  45              


Arg Thr Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Asn Val Tyr Tyr Gly Asn Asn Asp Val Lys Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr 
        115     


<210> 19
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      humanized GMA-2105 Heavy chain variable region version 2
      polypeptide

<400> 19
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
1               5                   10                  15      


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala Trp Met Asp 
            20                  25                  30          


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Glu Ile 
        35                  40                  45              


Arg Thr Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Asn Val Tyr Tyr Gly Asn Asn Asp Val Lys Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr 
        115     


<210> 20
<211> 98
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG1 CH1 polypeptide

<400> 20
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val 
        


<210> 21
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG1 hinge region peptide

<400> 21
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210> 22
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG1 CH2 polypeptide

<400> 22
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210> 23
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG1 CH3 polypeptide

<400> 23
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210> 24
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      IgG1 light chain constant region (kappa) polypeptide

<400> 24
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Ile Val Thr Lys Asp Tyr Ser Ala Glu Ser 
1               5                   10  


<210> 26
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Ile Val Thr Lys Asp Tyr Ser Lys Ala Ser 
1               5                   10  


<210> 27
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Ile Val Thr Lys Asp Tyr Ser Ala Ala Ser 
1               5                   10  


