               SEQUENCE LISTING

<110> Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

<120> Trans-differentiation of differentiated cells

<130> W3114 PCT

<150> EP14 15 3104.6
<151> 2014-01-29

<160> 17

<170> BiSSAP 1.2

<210> 1
<211> 239
<212> PRT
<213> Homo sapiens

<220> 
<223> Bcl-2 alpha isoform

<400> 1
Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      
Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          
Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              
Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  
Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  
Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      
Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         
Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             
Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 
Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 
Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     
Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         
Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             
Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 
Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 

<210> 2
<211> 192
<212> PRT
<213> Homo sapiens

<220> 
<223> Bax

<400> 2
Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Thr Ser Ser 
1               5                   10                  15      
Glu Gln Ile Met Lys Thr Gly Ala Leu Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          
Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp 
        35                  40                  45              
Pro Val Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Lys 
    50                  55                  60                  
Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  
Ala Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      
Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         
Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys 
        115                 120                 125             
Val Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu 
    130                 135                 140                 
Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp Gly 
145                 150                 155                 160 
Leu Leu Ser Tyr Phe Gly Thr Pro Thr Trp Gln Thr Val Thr Ile Phe 
                165                 170                 175     
Val Ala Gly Val Leu Thr Ala Ser Leu Thr Ile Trp Lys Lys Met Gly 
            180                 185                 190         



<210> 3
<211> 236
<212> PRT
<213> Mus musculus

<220> 
<223> Bcl-2

<400> 3
Met Ala Gln Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      
Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          
Gly Asp Ala Asp Ala Ala Pro Leu Gly Ala Ala Pro Thr Pro Gly Ile 
        35                  40                  45              
Phe Ser Phe Gln Pro Glu Ser Asn Pro Met Pro Ala Val His Arg Asp 
    50                  55                  60                  
Met Ala Ala Arg Thr Ser Pro Leu Arg Pro Leu Val Ala Thr Ala Gly 
65                  70                  75                  80  
Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr Leu Arg Arg 
                85                  90                  95      
Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe Ala Glu Met 
            100                 105                 110         
Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly Arg Phe Ala 
        115                 120                 125             
Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile 
    130                 135                 140                 
Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu Ser Val Asn 
145                 150                 155                 160 
Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp Met Thr Glu 
                165                 170                 175     
Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn Gly Gly Trp 
            180                 185                 190         
Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro Leu Phe Asp 
        195                 200                 205             
Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala Leu Val Gly 
    210                 215                 220                 
Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235     

<210> 4
<211> 192
<212> PRT
<213> Mus musculus

<220> 
<223> Bax

<400> 4
Met Asp Gly Ser Gly Glu Gln Leu Gly Ser Gly Gly Pro Thr Ser Ser 
1               5                   10                  15      
Glu Gln Ile Met Lys Thr Gly Ala Phe Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          
Asp Arg Ala Gly Arg Met Ala Gly Glu Thr Pro Glu Leu Thr Leu Glu 
        35                  40                  45              
Gln Pro Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Arg 
    50                  55                  60                  
Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  
Ala Asp Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      
Ala Asp Met Phe Ala Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         
Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys 
        115                 120                 125             
Val Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu 
    130                 135                 140                 
Arg Glu Arg Leu Leu Val Trp Ile Gln Asp Gln Gly Gly Trp Glu Gly 
145                 150                 155                 160 
Leu Leu Ser Tyr Phe Gly Thr Pro Thr Trp Gln Thr Val Thr Ile Phe 
                165                 170                 175     
Val Ala Gly Val Leu Thr Ala Ser Leu Thr Ile Trp Lys Lys Met Gly 
            180                 185                 190         



<210> 5
<211> 205
<212> PRT
<213> Homo sapiens

<220> 
<223> Bcl-2 beta isoform

<400> 5
Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      
Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          
Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              
Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  
Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  
Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      
Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         
Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             
Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 
Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 
Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     
Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         
Gly Gly Trp Val Gly Ala Leu Gly Asp Val Ser Leu Gly 
        195                 200                 205 

<210> 6
<211> 233
<212> PRT
<213> Homo sapiens

<220> 
<223> Bcl-XL

<400> 6
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      
Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          
Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              
Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  
Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  
Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      
Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         
His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             
Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 
Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 
Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     
His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         
Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             
Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 
Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             

<210> 7
<211> 193
<212> PRT
<213> Homo sapiens

<220> 
<223> Bcl-w or Bcl-2-like protein 2 or Bcl2L2

<400> 7
Met Ala Thr Pro Ala Ser Ala Pro Asp Thr Arg Ala Leu Val Ala Asp 
1               5                   10                  15      
Phe Val Gly Tyr Lys Leu Arg Gln Lys Gly Tyr Val Cys Gly Ala Gly 
            20                  25                  30          
Pro Gly Glu Gly Pro Ala Ala Asp Pro Leu His Gln Ala Met Arg Ala 
        35                  40                  45              
Ala Gly Asp Glu Phe Glu Thr Arg Phe Arg Arg Thr Phe Ser Asp Leu 
    50                  55                  60                  
Ala Ala Gln Leu His Val Thr Pro Gly Ser Ala Gln Gln Arg Phe Thr 
65                  70                  75                  80  
Gln Val Ser Asp Glu Leu Phe Gln Gly Gly Pro Asn Trp Gly Arg Leu 
                85                  90                  95      
Val Ala Phe Phe Val Phe Gly Ala Ala Leu Cys Ala Glu Ser Val Asn 
            100                 105                 110         
Lys Glu Met Glu Pro Leu Val Gly Gln Val Gln Glu Trp Met Val Ala 
        115                 120                 125             
Tyr Leu Glu Thr Arg Leu Ala Asp Trp Ile His Ser Ser Gly Gly Trp 
    130                 135                 140                 
Ala Glu Phe Thr Ala Leu Tyr Gly Asp Gly Ala Leu Glu Glu Ala Arg 
145                 150                 155                 160 
Arg Leu Arg Glu Gly Asn Trp Ala Ser Val Arg Thr Val Leu Thr Gly 
                165                 170                 175     
Ala Val Ala Leu Gly Ala Leu Val Thr Val Gly Ala Phe Phe Ala Ser 
            180                 185                 190         
Lys 
    

<210> 8
<211> 350
<212> PRT
<213> Homo sapiens

<220> 
<223> Mcl-1

<400> 8
Met Phe Gly Leu Lys Arg Asn Ala Val Ile Gly Leu Asn Leu Tyr Cys 
1               5                   10                  15      
Gly Gly Ala Gly Leu Gly Ala Gly Ser Gly Gly Ala Thr Arg Pro Gly 
            20                  25                  30          
Gly Arg Leu Leu Ala Thr Glu Lys Glu Ala Ser Ala Arg Arg Glu Ile 
        35                  40                  45              
Gly Gly Gly Glu Ala Gly Ala Val Ile Gly Gly Ser Ala Gly Ala Ser 
    50                  55                  60                  
Pro Pro Ser Thr Leu Thr Pro Asp Ser Arg Arg Val Ala Arg Pro Pro 
65                  70                  75                  80  
Pro Ile Gly Ala Glu Val Pro Asp Val Thr Ala Thr Pro Ala Arg Leu 
                85                  90                  95      
Leu Phe Phe Ala Pro Thr Arg Arg Ala Ala Pro Leu Glu Glu Met Glu 
            100                 105                 110         
Ala Pro Ala Ala Asp Ala Ile Met Ser Pro Glu Glu Glu Leu Asp Gly 
        115                 120                 125             
Tyr Glu Pro Glu Pro Leu Gly Lys Arg Pro Ala Val Leu Pro Leu Leu 
    130                 135                 140                 
Glu Leu Val Gly Glu Ser Gly Asn Asn Thr Ser Thr Asp Gly Ser Leu 
145                 150                 155                 160 
Pro Ser Thr Pro Pro Pro Ala Glu Glu Glu Glu Asp Asp Leu Tyr Arg 
                165                 170                 175     
Gln Ser Leu Glu Ile Ile Ser Arg Tyr Leu Arg Glu Gln Ala Thr Gly 
            180                 185                 190         
Ala Lys Asp Thr Lys Pro Met Gly Arg Ser Gly Ala Thr Ser Arg Lys 
        195                 200                 205             
Ala Leu Glu Thr Leu Arg Arg Val Gly Asp Gly Val Gln Arg Asn His 
    210                 215                 220                 
Glu Thr Ala Phe Gln Gly Met Leu Arg Lys Leu Asp Ile Lys Asn Glu 
225                 230                 235                 240 
Asp Asp Val Lys Ser Leu Ser Arg Val Met Ile His Val Phe Ser Asp 
                245                 250                 255     
Gly Val Thr Asn Trp Gly Arg Ile Val Thr Leu Ile Ser Phe Gly Ala 
            260                 265                 270         
Phe Val Ala Lys His Leu Lys Thr Ile Asn Gln Glu Ser Cys Ile Glu 
        275                 280                 285             
Pro Leu Ala Glu Ser Ile Thr Asp Val Leu Val Arg Thr Lys Arg Asp 
    290                 295                 300                 
Trp Leu Val Lys Gln Arg Gly Trp Asp Gly Phe Val Glu Phe Phe His 
305                 310                 315                 320 
Val Glu Asp Leu Glu Gly Gly Ile Arg Asn Val Leu Leu Ala Phe Ala 
                325                 330                 335     
Gly Val Ala Gly Val Gly Ala Gly Leu Ala Tyr Leu Ile Arg 
            340                 345                 350 

<210> 9
<211> 175
<212> PRT
<213> Homo sapiens

<220> 
<223> Bfl-1. bcl-2-related protein A1 isoform 1

<400> 9
Met Thr Asp Cys Glu Phe Gly Tyr Ile Tyr Arg Leu Ala Gln Asp Tyr 
1               5                   10                  15      
Leu Gln Cys Val Leu Gln Ile Pro Gln Pro Gly Ser Gly Pro Ser Lys 
            20                  25                  30          
Thr Ser Arg Val Leu Gln Asn Val Ala Phe Ser Val Gln Lys Glu Val 
        35                  40                  45              
Glu Lys Asn Leu Lys Ser Cys Leu Asp Asn Val Asn Val Val Ser Val 
    50                  55                  60                  
Asp Thr Ala Arg Thr Leu Phe Asn Gln Val Met Glu Lys Glu Phe Glu 
65                  70                  75                  80  
Asp Gly Ile Ile Asn Trp Gly Arg Ile Val Thr Ile Phe Ala Phe Glu 
                85                  90                  95      
Gly Ile Leu Ile Lys Lys Leu Leu Arg Gln Gln Ile Ala Pro Asp Val 
            100                 105                 110         
Asp Thr Tyr Lys Glu Ile Ser Tyr Phe Val Ala Glu Phe Ile Met Asn 
        115                 120                 125             
Asn Thr Gly Glu Trp Ile Arg Gln Asn Gly Gly Trp Glu Asn Gly Phe 
    130                 135                 140                 
Val Lys Lys Phe Glu Pro Lys Ser Gly Trp Met Thr Phe Leu Glu Val 
145                 150                 155                 160 
Thr Gly Lys Ile Cys Glu Met Leu Ser Leu Leu Lys Gln Tyr Cys 
                165                 170                 175 

<210> 10
<211> 163
<212> PRT
<213> Homo sapiens

<220> 
<223> Bfl-1. bcl-2-related protein A1 isoform 2

<400> 10
Met Thr Asp Cys Glu Phe Gly Tyr Ile Tyr Arg Leu Ala Gln Asp Tyr 
1               5                   10                  15      
Leu Gln Cys Val Leu Gln Ile Pro Gln Pro Gly Ser Gly Pro Ser Lys 
            20                  25                  30          
Thr Ser Arg Val Leu Gln Asn Val Ala Phe Ser Val Gln Lys Glu Val 
        35                  40                  45              
Glu Lys Asn Leu Lys Ser Cys Leu Asp Asn Val Asn Val Val Ser Val 
    50                  55                  60                  
Asp Thr Ala Arg Thr Leu Phe Asn Gln Val Met Glu Lys Glu Phe Glu 
65                  70                  75                  80  
Asp Gly Ile Ile Asn Trp Gly Arg Ile Val Thr Ile Phe Ala Phe Glu 
                85                  90                  95      
Gly Ile Leu Ile Lys Lys Leu Leu Arg Gln Gln Ile Ala Pro Asp Val 
            100                 105                 110         
Asp Thr Tyr Lys Glu Ile Ser Tyr Phe Val Ala Glu Phe Ile Met Asn 
        115                 120                 125             
Asn Thr Gly Glu Trp Ile Arg Gln Asn Gly Gly Trp Gly Lys Trp His 
    130                 135                 140                 
Asn His Thr Pro Met Leu Val Glu Ser Val Ala His Lys Lys Arg Lys 
145                 150                 155                 160 
Met Ala Leu 
            

<210> 11
<211> 194
<212> PRT
<213> Homo sapiens

<220> 
<223> Nrh

<400> 11
Met Ala Asp Pro Leu Arg Glu Arg Thr Glu Leu Leu Leu Ala Asp Tyr 
1               5                   10                  15      
Leu Gly Tyr Cys Ala Arg Glu Pro Gly Thr Pro Glu Pro Ala Pro Ser 
            20                  25                  30          
Thr Pro Glu Ala Ala Val Leu Arg Ser Ala Ala Ala Arg Leu Arg Gln 
        35                  40                  45              
Ile His Arg Ser Phe Phe Ser Ala Tyr Leu Gly Tyr Pro Gly Asn Arg 
    50                  55                  60                  
Phe Glu Leu Val Ala Leu Met Ala Asp Ser Val Leu Ser Asp Ser Pro 
65                  70                  75                  80  
Gly Pro Thr Trp Gly Arg Val Val Thr Leu Val Thr Phe Ala Gly Thr 
                85                  90                  95      
Leu Leu Glu Arg Gly Pro Leu Val Thr Ala Arg Trp Lys Lys Trp Gly 
            100                 105                 110         
Phe Gln Pro Arg Leu Lys Glu Gln Glu Gly Asp Val Ala Arg Asp Cys 
        115                 120                 125             
Gln Arg Leu Val Ala Leu Leu Ser Ser Arg Leu Met Gly Gln His Arg 
    130                 135                 140                 
Ala Trp Leu Gln Ala Gln Gly Gly Trp Asp Gly Phe Cys His Phe Phe 
145                 150                 155                 160 
Arg Thr Pro Phe Pro Leu Ala Phe Trp Arg Lys Gln Leu Val Gln Ala 
                165                 170                 175     
Phe Leu Ser Cys Leu Leu Thr Thr Ala Phe Ile Tyr Leu Trp Thr Arg 
            180                 185                 190         
Leu Leu 
        

<210> 12
<211> 233
<212> PRT
<213> Homo sapiens

<220> 
<223> Bcl-2-like 1 or Bcl2L1

<400> 12
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      
Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          
Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              
Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  
Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  
Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      
Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         
His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             
Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 
Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 
Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     
His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         
Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             
Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 
Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             

<210> 13
<211> 204
<212> PRT
<213> Homo sapiens

<220> 
<223> Bcl-2-like 10 or Bcl2L10 or DIVA

<400> 13
Met Val Asp Gln Leu Arg Glu Arg Thr Thr Met Ala Asp Pro Leu Arg 
1               5                   10                  15      
Glu Arg Thr Glu Leu Leu Leu Ala Asp Tyr Leu Gly Tyr Cys Ala Arg 
            20                  25                  30          
Glu Pro Gly Thr Pro Glu Pro Ala Pro Ser Thr Pro Glu Ala Ala Val 
        35                  40                  45              
Leu Arg Ser Ala Ala Ala Arg Leu Arg Gln Ile His Arg Ser Phe Phe 
    50                  55                  60                  
Ser Ala Tyr Leu Gly Tyr Pro Gly Asn Arg Phe Glu Leu Val Ala Leu 
65                  70                  75                  80  
Met Ala Asp Ser Val Leu Ser Asp Ser Pro Gly Pro Thr Trp Gly Arg 
                85                  90                  95      
Val Val Thr Leu Val Thr Phe Ala Gly Thr Leu Leu Glu Arg Gly Pro 
            100                 105                 110         
Leu Val Thr Ala Arg Trp Lys Lys Trp Gly Phe Gln Pro Arg Leu Lys 
        115                 120                 125             
Glu Gln Glu Gly Asp Val Ala Arg Asp Cys Gln Arg Leu Val Ala Leu 
    130                 135                 140                 
Leu Ser Ser Arg Leu Met Gly Gln His Arg Ala Trp Leu Gln Ala Gln 
145                 150                 155                 160 
Gly Gly Trp Asp Gly Phe Cys His Phe Phe Arg Thr Pro Phe Pro Leu 
                165                 170                 175     
Ala Phe Trp Arg Lys Gln Leu Val Gln Ala Phe Leu Ser Cys Leu Leu 
            180                 185                 190         
Thr Thr Ala Phe Ile Tyr Leu Trp Thr Arg Leu Leu 
        195                 200                 

<210> 14
<211> 350
<212> PRT
<213> Homo sapiens

<220> 
<223> myeloid cell leukemia sequence 1 isoform 1

<400> 14
Met Phe Gly Leu Lys Arg Asn Ala Val Ile Gly Leu Asn Leu Tyr Cys 
1               5                   10                  15      
Gly Gly Ala Gly Leu Gly Ala Gly Ser Gly Gly Ala Thr Arg Pro Gly 
            20                  25                  30          
Gly Arg Leu Leu Ala Thr Glu Lys Glu Ala Ser Ala Arg Arg Glu Ile 
        35                  40                  45              
Gly Gly Gly Glu Ala Gly Ala Val Ile Gly Gly Ser Ala Gly Ala Ser 
    50                  55                  60                  
Pro Pro Ser Thr Leu Thr Pro Asp Ser Arg Arg Val Ala Arg Pro Pro 
65                  70                  75                  80  
Pro Ile Gly Ala Glu Val Pro Asp Val Thr Ala Thr Pro Ala Arg Leu 
                85                  90                  95      
Leu Phe Phe Ala Pro Thr Arg Arg Ala Ala Pro Leu Glu Glu Met Glu 
            100                 105                 110         
Ala Pro Ala Ala Asp Ala Ile Met Ser Pro Glu Glu Glu Leu Asp Gly 
        115                 120                 125             
Tyr Glu Pro Glu Pro Leu Gly Lys Arg Pro Ala Val Leu Pro Leu Leu 
    130                 135                 140                 
Glu Leu Val Gly Glu Ser Gly Asn Asn Thr Ser Thr Asp Gly Ser Leu 
145                 150                 155                 160 
Pro Ser Thr Pro Pro Pro Ala Glu Glu Glu Glu Asp Glu Leu Tyr Arg 
                165                 170                 175     
Gln Ser Leu Glu Ile Ile Ser Arg Tyr Leu Arg Glu Gln Ala Thr Gly 
            180                 185                 190         
Ala Lys Asp Thr Lys Pro Met Gly Arg Ser Gly Ala Thr Ser Arg Lys 
        195                 200                 205             
Ala Leu Glu Thr Leu Arg Arg Val Gly Asp Gly Val Gln Arg Asn His 
    210                 215                 220                 
Glu Thr Ala Phe Gln Gly Met Leu Arg Lys Leu Asp Ile Lys Asn Glu 
225                 230                 235                 240 
Asp Asp Val Lys Ser Leu Ser Arg Val Met Ile His Val Phe Ser Asp 
                245                 250                 255     
Gly Val Thr Asn Trp Gly Arg Ile Val Thr Leu Ile Ser Phe Gly Ala 
            260                 265                 270         
Phe Val Ala Lys His Leu Lys Thr Ile Asn Gln Glu Ser Cys Ile Glu 
        275                 280                 285             
Pro Leu Ala Glu Ser Ile Thr Asp Val Leu Val Arg Thr Lys Arg Asp 
    290                 295                 300                 
Trp Leu Val Lys Gln Arg Gly Trp Asp Gly Phe Val Glu Phe Phe His 
305                 310                 315                 320 
Val Glu Asp Leu Glu Gly Gly Ile Arg Asn Val Leu Leu Ala Phe Ala 
                325                 330                 335     
Gly Val Ala Gly Val Gly Ala Gly Leu Ala Tyr Leu Ile Arg 
            340                 345                 350 

<210> 15
<211> 227
<212> PRT
<213> Homo sapiens

<220> 
<223> Bcl-x beta

<400> 15
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      
Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          
Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              
Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  
Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  
Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      
Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         
His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             
Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 
Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 
Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     
His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Val Arg Thr Lys 
            180                 185                 190         
Pro Leu Val Cys Pro Phe Ser Leu Ala Ser Gly Gln Arg Ser Pro Thr 
        195                 200                 205             
Ala Leu Leu Leu Tyr Leu Phe Leu Leu Cys Trp Val Ile Val Gly Asp 
    210                 215                 220                 
Val Asp Ser 
225         

<210> 16
<211> 427
<212> PRT
<213> Homo sapiens

<220> 
<223> Human Vitamin D receptor (Vdr)

<400> 16
Met Glu Ala Met Ala Ala Ser Thr Ser Leu Pro Asp Pro Gly Asp Phe 
1               5                   10                  15      
Asp Arg Asn Val Pro Arg Ile Cys Gly Val Cys Gly Asp Arg Ala Thr 
            20                  25                  30          
Gly Phe His Phe Asn Ala Met Thr Cys Glu Gly Cys Lys Gly Phe Phe 
        35                  40                  45              
Arg Arg Ser Met Lys Arg Lys Ala Leu Phe Thr Cys Pro Phe Asn Gly 
    50                  55                  60                  
Asp Cys Arg Ile Thr Lys Asp Asn Arg Arg His Cys Gln Ala Cys Arg 
65                  70                  75                  80  
Leu Lys Arg Cys Val Asp Ile Gly Met Met Lys Glu Phe Ile Leu Thr 
                85                  90                  95      
Asp Glu Glu Val Gln Arg Lys Arg Glu Met Ile Leu Lys Arg Lys Glu 
            100                 105                 110         
Glu Glu Ala Leu Lys Asp Ser Leu Arg Pro Lys Leu Ser Glu Glu Gln 
        115                 120                 125             
Gln Arg Ile Ile Ala Ile Leu Leu Asp Ala His His Lys Thr Tyr Asp 
    130                 135                 140                 
Pro Thr Tyr Ser Asp Phe Cys Gln Phe Arg Pro Pro Val Arg Val Asn 
145                 150                 155                 160 
Asp Gly Gly Gly Ser His Pro Ser Arg Pro Asn Ser Arg His Thr Pro 
                165                 170                 175     
Ser Phe Ser Gly Asp Ser Ser Ser Ser Cys Ser Asp His Cys Ile Thr 
            180                 185                 190         
Ser Ser Asp Met Met Asp Ser Ser Ser Phe Ser Asn Leu Asp Leu Ser 
        195                 200                 205             
Glu Glu Asp Ser Asp Asp Pro Ser Val Thr Leu Glu Leu Ser Gln Leu 
    210                 215                 220                 
Ser Met Leu Pro His Leu Ala Asp Leu Val Ser Tyr Ser Ile Gln Lys 
225                 230                 235                 240 
Val Ile Gly Phe Ala Lys Met Ile Pro Gly Phe Arg Asp Leu Thr Ser 
                245                 250                 255     
Glu Asp Gln Ile Val Leu Leu Lys Ser Ser Ala Ile Glu Val Ile Met 
            260                 265                 270         
Leu Arg Ser Asn Glu Ser Phe Thr Met Asp Asp Met Ser Trp Thr Cys 
        275                 280                 285             
Gly Asn Gln Asp Tyr Lys Tyr Arg Val Ser Asp Val Thr Lys Ala Gly 
    290                 295                 300                 
His Ser Leu Glu Leu Ile Glu Pro Leu Ile Lys Phe Gln Val Gly Leu 
305                 310                 315                 320 
Lys Lys Leu Asn Leu His Glu Glu Glu His Val Leu Leu Met Ala Ile 
                325                 330                 335     
Cys Ile Val Ser Pro Asp Arg Pro Gly Val Gln Asp Ala Ala Leu Ile 
            340                 345                 350         
Glu Ala Ile Gln Asp Arg Leu Ser Asn Thr Leu Gln Thr Tyr Ile Arg 
        355                 360                 365             
Cys Arg His Pro Pro Pro Gly Ser His Leu Leu Tyr Ala Lys Met Ile 
    370                 375                 380                 
Gln Lys Leu Ala Asp Leu Arg Ser Leu Asn Glu Glu His Ser Lys Gln 
385                 390                 395                 400 
Tyr Arg Cys Leu Ser Phe Gln Pro Glu Cys Ser Met Lys Leu Thr Pro 
                405                 410                 415     
Leu Val Leu Glu Val Phe Gly Asn Glu Ile Ser 
            420                 425         

<210> 17
<211> 422
<212> PRT
<213> Mus musculus

<220> 
<223> Mouse Vitamin D receptor (Vdr)

<400> 17
Met Glu Ala Met Ala Ala Ser Thr Ser Leu Pro Asp Pro Gly Asp Phe 
1               5                   10                  15      
Asp Arg Asn Val Pro Arg Ile Cys Gly Val Cys Gly Asp Arg Ala Thr 
            20                  25                  30          
Gly Phe His Phe Asn Ala Met Thr Cys Glu Gly Cys Lys Gly Phe Phe 
        35                  40                  45              
Arg Arg Ser Met Lys Arg Lys Ala Leu Phe Thr Cys Pro Phe Asn Gly 
    50                  55                  60                  
Asp Cys Arg Ile Thr Lys Asp Asn Arg Arg His Cys Gln Ala Cys Arg 
65                  70                  75                  80  
Leu Lys Arg Cys Val Asp Ile Gly Met Met Lys Glu Phe Ile Leu Thr 
                85                  90                  95      
Asp Glu Glu Val Gln Arg Lys Arg Glu Met Ile Met Lys Arg Lys Glu 
            100                 105                 110         
Glu Glu Ala Leu Lys Asp Ser Leu Arg Pro Lys Leu Ser Glu Glu Gln 
        115                 120                 125             
Gln His Ile Ile Ala Ile Leu Leu Asp Ala His His Lys Thr Tyr Asp 
    130                 135                 140                 
Pro Thr Tyr Ala Asp Phe Arg Asp Phe Arg Pro Pro Ile Arg Ala Asp 
145                 150                 155                 160 
Val Ser Thr Gly Ser Tyr Ser Pro Arg Pro Thr Leu Ser Phe Ser Gly 
                165                 170                 175     
Asp Ser Ser Ser Asn Ser Asp Leu Tyr Thr Pro Ser Leu Asp Met Met 
            180                 185                 190         
Glu Pro Ala Ser Phe Ser Thr Met Asp Leu Asn Glu Glu Gly Ser Asp 
        195                 200                 205             
Asp Pro Ser Val Thr Leu Asp Leu Ser Pro Leu Ser Met Leu Pro His 
    210                 215                 220                 
Leu Ala Asp Leu Val Ser Tyr Ser Ile Gln Lys Val Ile Gly Phe Ala 
225                 230                 235                 240 
Lys Met Ile Pro Gly Phe Arg Asp Leu Thr Ser Asp Asp Gln Ile Val 
                245                 250                 255     
Leu Leu Lys Ser Ser Ala Ile Glu Val Ile Met Leu Arg Ser Asn Gln 
            260                 265                 270         
Ser Phe Thr Leu Asp Asp Met Ser Trp Asp Cys Gly Ser Gln Asp Tyr 
        275                 280                 285             
Lys Tyr Asp Ile Thr Asp Val Ser Arg Ala Gly His Thr Leu Glu Leu 
    290                 295                 300                 
Ile Glu Pro Leu Ile Lys Phe Gln Val Gly Leu Lys Lys Leu Asn Leu 
305                 310                 315                 320 
His Glu Glu Glu His Val Leu Leu Met Ala Ile Cys Ile Val Ser Pro 
                325                 330                 335     
Asp Arg Pro Gly Val Gln Asp Ala Lys Leu Val Glu Ala Ile Gln Asp 
            340                 345                 350         
Arg Leu Ser Asn Thr Leu Gln Thr Tyr Ile Arg Cys Arg His Pro Pro 
        355                 360                 365             
Pro Gly Ser His Gln Leu Tyr Ala Lys Met Ile Gln Lys Leu Ala Asp 
    370                 375                 380                 
Leu Arg Ser Leu Asn Glu Glu His Ser Lys Gln Tyr Arg Ser Leu Ser 
385                 390                 395                 400 
Phe Gln Pro Glu Asn Ser Met Lys Leu Thr Pro Leu Val Leu Glu Val 
                405                 410                 415     
Phe Gly Asn Glu Ile Ser 
            420         

