                         SEQUENCE LISTING

<110>  The Secretary of State for Health
 
<120>  Adeno-associated viral vectors

<130>  P41951WO

<150>  GB1401707.3
<151>  2014-01-31

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  1331
<212>  DNA
<213>  Homo sapiens

<400>  1
ggggcctggt gtgattccgt cctgcgcggt tgttctctgg agcagcgttc ttttatctcc       60

gtccgccttc tctcctacct aagtgcgtgc cgccacccga tggaagattc gatggacatg      120

gacatgagcc ccctgaggcc ccagaactat cttttcggtt gtgaactaaa ggccgacaaa      180

gattatcact ttaaggtgga taatgatgaa aatgagcacc agttatcttt aagaacggtc      240

agtttagggg ctggtgcaaa ggatgagttg cacattgttg aagcagaggc aatgaattac      300

gaaggcagtc caattaaagt aacactggca actttgaaaa tgtctgtaca gccaacggtt      360

tcccttgggg gctttgaaat aacaccacca gtggtcttaa ggttgaagtg tggttcaggg      420

ccagtgcata ttagtggaca gcacttagta gctgtggagg aagatgcaga gtcagaagat      480

gaagaggagg aggatgtgaa actcttaagt atatctggaa agcggtctgc ccctggaggt      540

ggtagcaagg ttccacagaa aaaagtaaaa cttgctgctg atgaagatga tgacgatgat      600

gatgaagagg atgatgatga agatgatgat ggtgatgatt ttgatgatga ggaagctgaa      660

gaaaaagcgc cagtgaagaa atctatacga gatactccag ccaaaaatgc acaaaagtca      720

aatcagaatg gaaaagactc aaaaccatca tcaacaccaa gatcaaaagg acaagaatcc      780

ttcaagaaac aggaaaaaac tcctaaaaca ccaaaaggac ctagttctgt agaagacatt      840

aaagcaaaaa tgcaagcaag tatagaaaaa ggtggttctc ttcccaaagt ggaagccaaa      900

ttcatcaatt gtgtgaagaa ttgcttccgg atgactgacc aagaggctat tcaagatctc      960

tggcagtgga ggaagtctct ttaagaaaat agtttaaaca atttgttaaa aaattttccg     1020

tcttatttca tttctgtaac agttgatatc tggctgtcct ttttataatg cagagtgaga     1080

actttcccta ccgtgtttga taaatgttgt ccaggttcta ttgccaagaa tgtgttgtcc     1140

aaaatgccgt ttagttttta aagatggaac tccacccttt gcttggtttt aagtatgtat     1200

ggaatgttat gataggacat agtagtagcg gtggtcagac atggaaatgg tggggagaca     1260

aaaatataca tgtgaaataa aactcagtat tttaataaag tgaaaaaaaa aaaaaaaaaa     1320

aaaaaaaaaa a                                                          1331


<210>  2
<211>  10942
<212>  DNA
<213>  Homo sapiens

<400>  2
attctgctgt agacatagag atgatgatca tagctgacta tgatgatgat cccccgcgag       60

cctgaaagag gaaatgctct ggtttgctaa gcccgcgaat cgagtgagac ccacccacaa      120

agctaaccgt ggaagtcact ggcggcctcc ttcgccctgc cagccgggga acccatccgg      180

tggctctcga cctgctcccg ggccatctgg tgacactgac ttcgcagcca ccaccttaat      240

tggcgcattc gacccaaata ataacctggg aacctgtggg cggtctaagg cccggctctg      300

cggtcgccct cccaggcccc tctccctggc cctgtgaggc cagaaagtta cttctccgag      360

gccagttccc catgtctgag aaatatctcc caacttgagg ttctgtgggg taggggaggg      420

ttcgtgactt tctcacagaa aacctcgtac agaccccgcc actgccttta ttaacagctc      480

tcaggagact gcctgcagga ggggggtcgc tccggcccca tgctcgcggg caagcaggga      540

taagctgtgc ctccaaaagg gccaacggga actccgcggt ccctgaactt ccggtgctgg      600

aggactcctc gctccagggc caccaggagc cgcggcgtga gtgcgtgccg gaaccgaggg      660

cggggtctct gaggaactcc aaggctgccc aagcctacgg acccagccac attggcgaac      720

cggagaccgc ccgattccac cacccccgcg ctcccctcac agccggcgcc aaaaacgcca      780

gtcccacgac gcaggccggg acccgcgcgc ccacggccca atcagcgcga ccttgcacaa      840

agcgagcccc gcccccacgg cgccgttgcc agcccctccc cctcccgtgc cgcctcggcc      900

cgcctactcc ccgccccgcg ccgttcacgg ttagaggctc gcgattggct catggggacg      960

gccgcgagct ttggttggtc ggcgcggagt cacgaggcgc cgtcgtcgcc tttccacagg     1020

cgttactggg caggctcagt ctttcgcctc agtctcgagc tctcgctggc ttcgggtgta     1080

cgtgctccgg gatcttcagc acccgcggcc gccatcgccg tcgcttggct tcttctggac     1140

tcatctgcgc cacttgtccg cttcacactc cgccgccatc atggtgaagc tcgcgaaggt     1200

aaacggcctt gagcgcgacg cagacgtgta ggcctgcttc cgaggggcga gcgcggcgcc     1260

gcggggagga gggcctgcgc gcagtcccgg gcgcgttcta gggcgccatg ctgcgggaag     1320

tctcgcgcga ttagtgggga ggtctcgcgc ttctggctac ttggtggcga ggtgaagagc     1380

ttctgcaggt gctgggggag ggggcgctgg gcctcggggt ggagagatga gaccaaactt     1440

ttgcgacgcg tacgagctgg gactgactct gacgcacgtg cccgggagcg tgcctgccac     1500

gtgggccggc gtaggtctgg aatctccaga gggaccgggt gccttgggcc gggaaatggc     1560

ggtatcggcc ctagtcggag tcccggctgc gctcggatgt ctccgccccg gcctggcaag     1620

ccgatacgtg gtgggccccg gaaggtggct ctgccgcgtg ccttttgcgc tgtgtttcgg     1680

gcaagaggtg gtcctgccag gtacccccac gtggccgcac ccgcctcttt aaggggcggg     1740

gtagtgctgg ggaaaggcat aagcttcatg agaaaataag gtagtatttt taagtgcctt     1800

aatgatcttc accgttaatt tgattcaaat aagggtggta gataaagtac cgggatttgt     1860

agtataaaaa cacggttgtg cttaactaag gtaacgggag gagaaatcat ttcctcaggt     1920

tgacttttta ccttagggca ggttttctgt tggtaaagcc tgggaggaaa aatgtgggcg     1980

gttgagaagt agtccctctt gcattgccat caggagtagt ttctatgtta gttgtggtgt     2040

ttggcactat gagaaatgat ctgagacgga gatgatggcg tatgaacact aatggcaaaa     2100

tatgaatggc ctgaaatgtc gaggtggagg tgtaatgatc tatttgtgtc cattttaggc     2160

aggtaaaaat caaggtgacc ccaagaaaat ggctcctcct ccaaaggagg tagaagaaga     2220

tagtgaagat gaggaaatgt cagaagatga agaagatgat agcagtggag aagaggtaat     2280

tttatccaac ttaatgcaga attatgttaa aactacaaaa tggagagtta agacatgaaa     2340

ttggatatct gtggcaaaaa taagatttta tcaggtatgt cttattgtag tggttgagtg     2400

tttcacaagc tcttcattga catgtcaaga tgtcatttgg ctagtatttg aatgtgagtg     2460

ctaagacgag actgggaatt tcttttacat gttcctctgc agggcttgga gtgtgatttg     2520

ttgtgttaaa tcattacatt tttccagttt caacatgtta gctcaccccc acatgtagag     2580

ctgggcattg tattcagagc tgagaataac cttaccagat tcctttccta tcctccgaat     2640

taaaattaat tggtctccat tccatatata tataactgta tcactactgg ttaagtactc     2700

gggtgtagac tgagggctgc cacctctctt tggtaccatt gaccctcttt agccacctcc     2760

tggcctttta tttgcctcca ctataaagac agctgagcac tgaattgtgc tcaggttttc     2820

gttgagaacc tgaatgaaag ttttactctc cacacattgc cttgataaaa ctacgggatt     2880

ttaatgtagc taaatgatga cttttatcaa actaccatgc acactctttg atgtgtgata     2940

gttttgtaag gaatatttat atttagccta ttcatttttt gtctcaggtc ctaagaattg     3000

agcttcactg ggcttggtgg accgcaacca cgagggcccc aatgatttaa taagttaatg     3060

cttggagcct cctatgtgta acgttctgaa taatttacac atagcaattc atgaccttaa     3120

acatgtaagg atgatactat taccattttc agatgagaaa gttggggctt gggaaagtat     3180

gaggtgtaag aattcagagg gtctggttca gaggtatttt cagtgttcaa aagagttcct     3240

tatgtctggg tattcacctt attatagggg ctctgactta agacaacata acagaagcct     3300

ggagttttaa catgtcatat gtgtcatgcg tatgtcttga accagaggca ttgccagagt     3360

ctaacaactc attgggacca tggttatctt tttgggtgtg gggctggact tactggtttg     3420

gttttcattt atctcaaggt cgtcatacct cagaagaaag gcaagaaggc tgctgcaacc     3480

tcagcaaaga aggtggtcgt ttccccaaca aaaaaggttg cagttgccac accagccaag     3540

aaagcagctg tcactccagg caaaaaggca gcagcaacac ctgccaagaa gacagttaca     3600

ccagccaaag cagttaccac acctggcaag aagggagcca caccaggcaa agcattggta     3660

gcaactcctg gtaagaaggg tgctgccatc ccagccaagg gggcaaagaa tggcaagaat     3720

gccaagaagg aagacagtga tgaagaggag gatgatgaca gtgaggagga tgaggaggat     3780

gacgaggacg aggatgagga tgaagatgaa attgaaccag cagcgatgaa agcagcagct     3840

gctgcccctg cctcagagga tgaggacgat gaggatgacg aagatgatga ggatgacgat     3900

gacgatgagg aagatggtaa ggagttgtct tggtagttac tgggcttctg attacaaggt     3960

atcttgagat tctgggatca catattcctt catcgtacaa cctggagatg agattagaat     4020

cttgtgggaa ttctcttggg ttgttgtggt gtgctagact taattaccca tgaatgattt     4080

tgtcctcttg agaaaatttc aatagcacat ctattagtgt tttttataat gtaggatttt     4140

cgtttctaag tgattttttt ttttttttaa atttttttga gatggagctt ttgctgtttc     4200

ccaggcggga gtgcaatggc gcgctatctc ggcgcactgc agcctccatc tcctgggttc     4260

aagcagttct gcctcagcct cccgagtagc gggattacag gtgcccacca ccacacccta     4320

ctaattttgt attttagtag agacgacatt tcaccatgtt ggccaggctg gctctgaact     4380

ttgacctcag gtgatccacc caccttaggc tctcccaaag tgctaggatt acaggtgaga     4440

tatgctgcgc ccggccccaa gtgatctatt cttgccatga ctgttaacta aacatggtga     4500

caggattcga ttttctttac attagatttg aaaaccgatg ttggttttgg gagattgctg     4560

caatttttag gtgacttctc tttcagactc tgaagaagaa gctatggaga ctacaccagc     4620

caaaggaaag aaagctgcaa aagttgttcc tgtgaaagcc aagaacgtgg ctgaggatga     4680

agatgaagaa gaggatgatg aggacgagga tgacgacgac gacgaagatg atgaagatga     4740

tgatgatgaa gatgatgagg aggaggaaga agaggaggag gaaggtactt aaattagatt     4800

ctgacatacg acatgagtta tgtttaaagg aggcacttaa gtgtttgtgg ctactgatgt     4860

gtgatacatt gtttgacatc ttgtccagag cctgtcaaag aagcacctgg aaaacgaaag     4920

aaggaaatgg ccaaacagaa agcagctcct gaagccaaga aacagaaagt ggaaggtaac     4980

ttgcagaatt aggggatatg ggggagataa acagcacaaa tgatgaataa caaagggact     5040

taatactgaa accagatgtt acattgtagt gtgctgatgt gctgtgtata gaaattttgc     5100

tttggaaact aactttttac cacactacaa gtagactgag ttgagctttt tttgtgcagg     5160

cacagaaccg actacggctt tcaatctctt tgttggaaac ctaaacttta acaaatctgc     5220

tcctgaatta aaaactggta tcagcgatgt ttttgctaaa aatgatcttg ctgttgtgga     5280

tgtcagaatt ggtatgacta ggtagctgct tcactgcacg ttacataccg tgggtctgtt     5340

aatttttcct tcccctgtta gcacagttac tttagcctgc cactgttaaa catgaatact     5400

gtaaacactt caaggttagc attagtgaac taagttagaa ttaaactgta gatcccctaa     5460

gttgcaattt ccataatcag tcgtaacttg gtatagcaca gaataatttt tagtaatttt     5520

tttgttgttt ttgttatgta ttgagacgga cgctggcttt tgttcaggct ggagtacagt     5580

ggcgcaatct tggctcactg caacctctgc ctcccgggtt caagcgattc tcctgcctaa     5640

cctcccaagt gactgggata cgggtgccac tcaccatgca tggctaattt ttgttttgta     5700

tttagtatcg atttcaccat gttggtcggc tggttttgaa ctcctgacct caagtgatcc     5760

acccacctcg gcctctcgaa gtgctggtac agcgtcacca ccctgccagt aagttttaat     5820

aatttggtgt taggtgggag aatgcttgaa cctgggaggc agaggttgca gtgagccaag     5880

ttcgcgccac tgtactccag cctgggcaac agattgagac accgtctcaa tttaaaataa     5940

tgtttatttt cttggaagta ccttgaaact attagacctg tctagtcatc atagtgaata     6000

cttttatcca gacaggattc tcctgtatta gtgcttatag gtgttctttt gtcagctgct     6060

actgtgaatt cttataagca atttagctcc atgatgaaga cctcaaacgt gaatgtgcat     6120

gtcatatctt catgctgagc cgtgttctgt agctgcagtt tgcagagcct tgactttgtt     6180

ttgctatact aggggtgctt tttaaaatgt gatctttgtt tgcaccatca catttgtcta     6240

gatacagatt gtgattttga tttgtgtttt cacctgttgt aattttgccc tcctctccac     6300

ctgaaggaaa tttggttatg tggattttga atctgctgaa gacctggaga aagcgttgga     6360

actcactggt ttgaaagtct ttggcaatga aattaaacta gagaaaccaa aaggaaaaga     6420

cagtaagaaa ggtatgtaag gctttatgag ttatgcaatg aactcaggag ctagactgct     6480

agggaaaatg ctttgtaacc catttccctt tggtttcctc ttattttttt taaatcattt     6540

ttttcctttg gtttcctctt aatgtgggaa ttaaatgagc tacagtgttt acaaggtact     6600

tggcactgct tgtcagtgta taggtaaatt cctgagttag gcaagcaaga gcactcttat     6660

acagaacaag aaccattaca tgcacctaaa ttaagctaag gatctttctt cactgaaact     6720

agttaggtcc ctaattactc cctatataca gtgtaatgtt ttgaattggt acattcactt     6780

tttttgttat gcgcgtctac tctaggttga actccagtgt acctaacaga gagtttgaca     6840

tcaaggctgt gacaacatgg agggaccact tgtgtgttga cactgctata tctccatatt     6900

tagcaccgag ccttgtacat ataggatctc aaattatttg ttgatagagc tatgtgtgtt     6960

tttcccctct ttttgttgtt gccccccacc tttggttttt caggccacag agctcatttt     7020

tgttttttta atctagagcg agatgcgaga acacttttgg ctaaaaatct cccttacaaa     7080

gtcactcagg atgaattgaa agaagtgttt gaagatgctg cggagatcag attagtcagc     7140

aaggatggga aaagtaaagg gtatgttctt ctattgaaat gtaagggttt tattaacatt     7200

aatgcacttc ctgctttata aaagaaatat tggtttgatt tccttaggcg tgtaacttgg     7260

acagtttaac ctgtaagttt gtgcctcagt aacccatctg taccatgggg ataatgtact     7320

catagggtga ttttaaaaga caaagctaat acttacaaag aagcaagttt aatgcctatc     7380

ttacataaat actttgtaag tagtagcagt tctttcagtg aggtgaggtt acatgaaaaa     7440

attccaagta tttgtaaaac tagtgggaag taagagggaa gctcgagttt tgattgaaaa     7500

gtggactaaa caagggcatt ttatgtactc agatctgaag caagttctgt gttgctgagg     7560

taaaagcatt tgtgttaata tggttttaaa aaccatgagt tcttctccct ccattgcagg     7620

attgcttata ttgaatttaa gacagaagct gatgcagaga aaacctttga agaaaagcag     7680

ggaacagaga tcgatgggcg atctatttcc ctgtactata ctggagagaa aggtcaaaat     7740

caagactata gaggtggaaa gaatagcact tggagtggta agaaattagg cttgttccaa     7800

ggttttcaga attggttgag ggaactcttc tagtctttgt atttcataag tttataaata     7860

ctttttaatc aaagttactc aaatgtaggt gaagatcaag gacatgatac cccaagtcat     7920

actcttattt ggaatagtaa tttccaatct tgaaatgaga gctctaaatc attttgcatt     7980

ggaatacagt aggcaaatca agcttccttt gtaggcatgt tttatacttt aaatgacttg     8040

accatgtgcg ttttgaactc agatgattct aggaaaacag accagtcatc agcctatgta     8100

agaacaacca gcaggacatt gcaacacgta ctaggtactt aatatgttga gtaacagaaa     8160

tggatttagc ttacgtcatg agtatttgta tataactcaa gcactgaaat tcttagggaa     8220

tagatattac tgttgtgacc gaagctggga cactgtttca gagtcttagg aatgtggctc     8280

tctatttcga ggtgaatcaa aaactctggt tttaagcaac ctctcctaca gtgcaacaga     8340

agaaactctt caggaagtat ttgagaaagc aacttttatc aaagtacccc agaaccaaaa     8400

tggcaaatct aaagggtaag ataatacctt tgtatcatca gttataggcc tatatatgtc     8460

ttagaggtct aaggacgtaa ggtcatgtgt cctgtagaaa aaagctaaat aattttagcc     8520

tagtaaatga gtgtaaaata agtatattta ggtccaacct tgagagaagg gccttggcca     8580

gatcatgtga ccagtggtat agagagcatg tgcctggtaa attactctaa gcattaactg     8640

ttcatcctca ggtatgcatt tatagagttt gcttcattcg aagacgctaa agaagcttta     8700

aattcctgta ataaaaggga aattgagggc agagcaatca ggctggagtt gcaaggaccc     8760

aggggatcac ctaatgccag aagccgtaag ttcacctggt tagggtgctg tggttggggg     8820

tagcactctc ggtgctttgt ttatttttgc acaaattctg tgtttcctgt tcgctactga     8880

gtgaacaata actggatatc gatgactgat tacctgagaa ataattgatg aaatctcaag     8940

aaaattcctc tagatagtca agttctgatc cagctgtcgt caactcagag tagcaagttt     9000

gcccatgatt tcctgcccca tccactgggc cccacctgct tgggttgctt tcccactttc     9060

catagaagac tggggcagga tatcaactat gcaatggcaa ttaaaaaatg taaacccaga     9120

atagccttta ctttaattaa ggactagttg gcttagttgc ttttaactgc tttttcacta     9180

taacaagtat cttggctagt agtcatacta ggcattgtgc aaattcagtg tacgaactgt     9240

gaattcacat aaatcgcaaa tttttttttc cttcccagag ccatccaaaa ctctgtttgt     9300

caaaggcctg tctgaggata ccactgaaga gacattaaag gagtcatttg acggctccgt     9360

tcgggcaagg atagttactg accgggaaac tgggtcctcc aaagggtaag ggaaggaagc     9420

gtgagtgctg cttccacttg aaggggtttt tgttctgtgc agaccttgag tctaatgtgt     9480

cttctcattg agctccttct gtctatcagt ggcagtttat ggattcgcac gagaagaaga     9540

gagaattcac agaactagca ttattttacc ttctgtcttt acagaggtat atttagctgt     9600

attgtgagac attctggggt tcaagctgtc acaccagtta gttttccata gagagctact     9660

ctgctgcact ggtatctttt tcccaaataa acaaggctac ttctgtggga tggctcccca     9720

gcatgtacag ttaacttggg acatgtgtag taggtgcttt ttataatggg caatttcatt     9780

tggtgttcta ggtttggttt tgtagacttc aacagtgagg aggatgccaa ggaggccatg     9840

gaagacggtg aaattgatgg aaataaagtt accttggact gggccaaacc taagggtgaa     9900

ggtggcttcg ggggtcgtgg tggaggcaga ggcggctttg gaggacgagg tggtggtaga     9960

ggaggccgag gaggatttgg tggcagaggc cggggaggct ttggaggtaa ggcacgcaga    10020

gataatgaca ccacatagca tgtgctcttc agaccctgtg ccctgtcacg gttcctaatc    10080

actggggagg aggagctttg tacccattct tttaacagtg tcttgccttc ctcctgtagg    10140

gcgaggaggc ttccgaggag gcagaggagg aggaggtgac cacaagccac aaggaaagaa    10200

gacgaagttt gaatagcttc tgtccctctg ctttcccttt tccatttgaa agaaaggact    10260

ctggggtttt tactgttacc tgatcaatga cagagccttc tgaggacatt ccaagacagt    10320

atacagtcct gtggtctcct tggaaatccg tctagttaac atttcaaggg caataccgtg    10380

ttggttttga ctggatattc atataaactt tttaaagagt tgagtgatag agctaaccct    10440

tatctgtaag ttttgaattt atattgtttc atcccatgta caaaaccatt ttttcctaca    10500

aatagtttgg gttttgttgt tgttactttt ttttttgttt ttgttttttt tttttttgcg    10560

ttcgtggggt tgtaaaagaa aagaaagcag aatgttttat catggttttt gcttcaccgc    10620

tttaggacaa attaaaagtc aactctggtg ccagacgtgt tacttcctaa agagtgtttc    10680

ccctggaatc tcactggaga gcatggcaaa gccagctctg ccacttgctt cacccatccc    10740

aatggaaatg gcttagtgcg tgtttccagt atcccagccc taactaactt ggttgaaatg    10800

ctggtgaggg gacctgctcc tgcagccctg gtgctgactt gaaggctgct gcagcttctc    10860

ctacttttag caggtctcga ggattatgtc tgaagaccac tctggaaaga ggtcgaggaa    10920

cagattagtc aggtttccta gg                                             10942


<210>  3
<211>  1561
<212>  DNA
<213>  Homo sapiens

<400>  3
gggcttatcc cgcctgtccc gccattctcg ctagttcgat cggtagcggg agcggagagc       60

ggaccccaga gagccctgag cagccccacc gccgccgccg gcctagttac catcacaccc      120

cgggaggagc cgcagctgcc gcagccggcc ccagtcacca tcaccgcaac catgagcagc      180

gaggccgaga cccagcagcc gcccgccgcc ccccccgccg cccccgccct cagcgccgcc      240

gacaccaagc ccggcactac gggcagcggc gcagggagcg gtggcccggg cggcctcaca      300

tcggcggcgc ctgccggcgg ggacaagaag gtcatcgcaa cgaaggtttt gggaacagta      360

aaatggttca atgtaaggaa cggatatggt ttcatcaaca ggaatgacac caaggaagat      420

gtatttgtac accagactgc cataaagaag aataacccca ggaagtacct tcgcagtgta      480

ggagatggag agactgtgga gtttgatgtt gttgaaggag aaaagggtgc ggaggcagca      540

aatgttacag gtcctggtgg tgttccagtt caaggcagta aatatgcagc agaccgtaac      600

cattatagac gctatccacg tcgtaggggt cctccacgca attaccagca aaattaccag      660

aatagtgaga gtggggaaaa gaacgaggga tcggagagtg ctcccgaagg ccaggcccaa      720

caacgccggc cctaccgcag gcgaaggttc ccaccttact acatgcggag accctatggg      780

cgtcgaccac agtattccaa ccctcctgtg cagggagaag tgatggaggg tgctgacaac      840

cagggtgcag gagaacaagg tagaccagtg aggcagaata tgtatcgggg atatagacca      900

cgattccgca ggggccctcc tcgccaaaga cagcctagag aggacggcaa tgaagaagat      960

aaagaaaatc aaggagatga gacccaaggt cagcagccac ctcaacgtcg gtaccgccgc     1020

aacttcaatt accgacgcag acgcccagaa aaccctaaac cacaagatgg caaagagaca     1080

aaagcagccg atccaccagc tgagaattcg tccgctcccg aggctgagca gggcggggct     1140

gagtaaatgc cggcttacca tctctaccat catccggttt agtcatccaa caagaagaaa     1200

tatgaaattc cagcaataag aaatgaacaa aagattggag ctgaagacct aaagtgcttg     1260

ctttttgccc gttgaccaga taaatagaac tatctgcatt atctatgcag catggggttt     1320

ttattatttt tacctaaaga cgtctctttt tggtaataac aaacgtgttt tttaaaaaag     1380

cctggttttt ctcaatacgc ctttaaaggt ttttaaattg tttcatatct ggtcaagttg     1440

agatttttaa gaacttcatt tttaatttgt aataaaagtt tacaacttga ttttttcaaa     1500

aaagtcaaca aactgcaagc acctgttaat aaaggtctta aataataaaa aaaaaaaaaa     1560

a                                                                     1561


<210>  4
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  4
ccgggccaag aatgtgttgt ccaaactcga gtttggacaa cacattcttg gctttttg         58


<210>  5
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  5
ccgggcgcca gtgaagaaat ctatactcga gtatagattt cttcactggc gctttttg         58


<210>  6
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  6
ccgggcaaag gatgagttgc acattctcga gaatgtgcaa ctcatccttt gctttttg         58


<210>  7
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  7
ccggcctagt tctgtagaag acattctcga gaatgtcttc tacaggaact aggtttttg        59


<210>  8
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  8
ccggcctagt tctgtagaag acattctcga gaatgtcttc tacagaacta ggtttttg         58


<210>  9
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  9
ccggccttgg aaatccgtct agttactcga gtaactagac ggatttccaa ggtttttg         58


<210>  10
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  10
ccggccggtg aaattgatgg aaataactcg agttatttcc atcaatttca ccgtttttg        59


<210>  11
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  11
ccggcggtga aattgatgga aataactcga gttatttcca tcaatttcac cgtttttg         58


<210>  12
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  12
ccggagtaaa gggattgctt atattctcga gaatataagc aatcccttta cttttttg         58


<210>  13
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  13
ccggcgttcg gggcaaggat agttacctcg aggtaactat ccttgcccga acgtttttg        59


<210>  14
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  14
ccgggcagtt caaggcagta aatatctcga gatatttact gccttgaact ggtttttg         58


<210>  15
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  15
ccggagcaga ccgtaaccat tatagctcga gctataatgg ttacggtctg cttttttg         58


<210>  16
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  16
ccgggcttac catctctacc atcatctcga gatgatggta gagatggtaa gcttttt          57


<210>  17
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  17
ccgggacggc aatgaagaag ataaactcga gtttatcttc ttcattgccg tcttttt          57


<210>  18
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  18
ccggccagtt caaggcagta aatatctcga gatatttact gccttgaact ggttttt          57


<210>  19
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  19
ccgggccatc aaacaagttt atgaactcga gttcataaac ttgtttgatg gcttttt          57


<210>  20
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  20
ccgggctgga attgatgaag ctcaactcga gttgagcttc atcaattcca gcttttt          57


<210>  21
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  21
ccggccatga ttaagggaga tacatctcga gatgtatctc ccttaatcat ggttttt          57


<210>  22
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  22
ccggcgcgag acttctggca atttactcga gtaaattgcc agaagtctcg cgttttt          57


<210>  23
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  23
ccgggcatcc tgactctgtt gacatctcga gatgtcaaca gagtcaggat gcttttt          57


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  24
ggaaccccta gtgatggagt t                                                 21


<210>  25
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  25
cggcctcagt gagcga                                                       16


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  26
cactccctct ctgcgcgctc g                                                 21


<210>  27
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn 
1               5                   10                  15      


Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys 
            20                  25                  30          


Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser 
        35                  40                  45              


Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala 
    50                  55                  60                  


Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys 
65                  70                  75                  80  


Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro 
                85                  90                  95      


Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser 
            100                 105                 110         


Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu 
        115                 120                 125             


Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala 
    130                 135                 140                 


Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala 
145                 150                 155                 160 


Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp 
                165                 170                 175     


Asp Gly Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val 
            180                 185                 190         


Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn 
        195                 200                 205             


Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly 
    210                 215                 220                 


Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly 
225                 230                 235                 240 


Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu 
                245                 250                 255     


Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Cys Val 
            260                 265                 270         


Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp 
        275                 280                 285             


Gln Trp Arg Lys Ser Leu 
    290                 


<210>  28
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Val Lys Leu Ala Lys Ala Gly Lys Asn Gln Gly Asp Pro Lys Lys 
1               5                   10                  15      


Met Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu 
            20                  25                  30          


Met Ser Glu Asp Glu Glu Asp Asp Ser Ser Gly Glu Glu Val Val Ile 
        35                  40                  45              


Pro Gln Lys Lys Gly Lys Lys Ala Ala Ala Thr Ser Ala Lys Lys Val 
    50                  55                  60                  


Val Val Ser Pro Thr Lys Lys Val Ala Val Ala Thr Pro Ala Lys Lys 
65                  70                  75                  80  


Ala Ala Val Thr Pro Gly Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys 
                85                  90                  95      


Thr Val Thr Pro Ala Lys Ala Val Thr Thr Pro Gly Lys Lys Gly Ala 
            100                 105                 110         


Thr Pro Gly Lys Ala Leu Val Ala Thr Pro Gly Lys Lys Gly Ala Ala 
        115                 120                 125             


Ile Pro Ala Lys Gly Ala Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp 
    130                 135                 140                 


Ser Asp Glu Glu Glu Asp Asp Asp Ser Glu Glu Asp Glu Glu Asp Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Glu Asp Glu Asp Glu Ile Glu Pro Ala Ala Met Lys 
                165                 170                 175     


Ala Ala Ala Ala Ala Pro Ala Ser Glu Asp Glu Asp Asp Glu Asp Asp 
            180                 185                 190         


Glu Asp Asp Glu Asp Asp Asp Asp Asp Glu Glu Asp Asp Ser Glu Glu 
        195                 200                 205             


Glu Ala Met Glu Thr Thr Pro Ala Lys Gly Lys Lys Ala Ala Lys Val 
    210                 215                 220                 


Val Pro Val Lys Ala Lys Asn Val Ala Glu Asp Glu Asp Glu Glu Glu 
225                 230                 235                 240 


Asp Asp Glu Asp Glu Asp Asp Asp Asp Asp Glu Asp Asp Glu Asp Asp 
                245                 250                 255     


Asp Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro 
            260                 265                 270         


Val Lys Glu Ala Pro Gly Lys Arg Lys Lys Glu Met Ala Lys Gln Lys 
        275                 280                 285             


Ala Ala Pro Glu Ala Lys Lys Gln Lys Val Glu Gly Thr Glu Pro Thr 
    290                 295                 300                 


Thr Ala Phe Asn Leu Phe Val Gly Asn Leu Asn Phe Asn Lys Ser Ala 
305                 310                 315                 320 


Pro Glu Leu Lys Thr Gly Ile Ser Asp Val Phe Ala Lys Asn Asp Leu 
                325                 330                 335     


Ala Val Val Asp Val Arg Ile Gly Met Thr Arg Lys Phe Gly Tyr Val 
            340                 345                 350         


Asp Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala Leu Glu Leu Thr Gly 
        355                 360                 365             


Leu Lys Val Phe Gly Asn Glu Ile Lys Leu Glu Lys Pro Lys Gly Lys 
    370                 375                 380                 


Asp Ser Lys Lys Glu Arg Asp Ala Arg Thr Leu Leu Ala Lys Asn Leu 
385                 390                 395                 400 


Pro Tyr Lys Val Thr Gln Asp Glu Leu Lys Glu Val Phe Glu Asp Ala 
                405                 410                 415     


Ala Glu Ile Arg Leu Val Ser Lys Asp Gly Lys Ser Lys Gly Ile Ala 
            420                 425                 430         


Tyr Ile Glu Phe Lys Thr Glu Ala Asp Ala Glu Lys Thr Phe Glu Glu 
        435                 440                 445             


Lys Gln Gly Thr Glu Ile Asp Gly Arg Ser Ile Ser Leu Tyr Tyr Thr 
    450                 455                 460                 


Gly Glu Lys Gly Gln Asn Gln Asp Tyr Arg Gly Gly Lys Asn Ser Thr 
465                 470                 475                 480 


Trp Ser Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser Tyr Ser 
                485                 490                 495     


Ala Thr Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr Phe Ile 
            500                 505                 510         


Lys Val Pro Gln Asn Gln Asn Gly Lys Ser Lys Gly Tyr Ala Phe Ile 
        515                 520                 525             


Glu Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser Cys Asn 
    530                 535                 540                 


Lys Arg Glu Ile Glu Gly Arg Ala Ile Arg Leu Glu Leu Gln Gly Pro 
545                 550                 555                 560 


Arg Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu Phe Val 
                565                 570                 575     


Lys Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu Ser Phe 
            580                 585                 590         


Asp Gly Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr Gly Ser 
        595                 600                 605             


Ser Lys Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp Ala Lys 
    610                 615                 620                 


Glu Ala Met Glu Asp Gly Glu Ile Asp Gly Asn Lys Val Thr Leu Asp 
625                 630                 635                 640 


Trp Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly Gly Arg Gly Gly Gly 
                645                 650                 655     


Arg Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Gly 
            660                 665                 670         


Phe Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Phe Arg 
        675                 680                 685             


Gly Gly Arg Gly Gly Gly Gly Asp His Lys Pro Gln Gly Lys Lys Thr 
    690                 695                 700                 


Lys Phe Glu 
705         


<210>  29
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ser Ser Glu Ala Glu Thr Gln Gln Pro Pro Ala Ala Pro Pro Ala 
1               5                   10                  15      


Ala Pro Ala Leu Ser Ala Ala Asp Thr Lys Pro Gly Thr Thr Gly Ser 
            20                  25                  30          


Gly Ala Gly Ser Gly Gly Pro Gly Gly Leu Thr Ser Ala Ala Pro Ala 
        35                  40                  45              


Gly Gly Asp Lys Lys Val Ile Ala Thr Lys Val Leu Gly Thr Val Lys 
    50                  55                  60                  


Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr 
65                  70                  75                  80  


Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro 
                85                  90                  95      


Arg Lys Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp 
            100                 105                 110         


Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro 
        115                 120                 125             


Gly Gly Val Pro Val Gln Gly Ser Lys Tyr Ala Ala Asp Arg Asn His 
    130                 135                 140                 


Tyr Arg Arg Tyr Pro Arg Arg Arg Gly Pro Pro Arg Asn Tyr Gln Gln 
145                 150                 155                 160 


Asn Tyr Gln Asn Ser Glu Ser Gly Glu Lys Asn Glu Gly Ser Glu Ser 
                165                 170                 175     


Ala Pro Glu Gly Gln Ala Gln Gln Arg Arg Pro Tyr Arg Arg Arg Arg 
            180                 185                 190         


Phe Pro Pro Tyr Tyr Met Arg Arg Pro Tyr Gly Arg Arg Pro Gln Tyr 
        195                 200                 205             


Ser Asn Pro Pro Val Gln Gly Glu Val Met Glu Gly Ala Asp Asn Gln 
    210                 215                 220                 


Gly Ala Gly Glu Gln Gly Arg Pro Val Arg Gln Asn Met Tyr Arg Gly 
225                 230                 235                 240 


Tyr Arg Pro Arg Phe Arg Arg Gly Pro Pro Arg Gln Arg Gln Pro Arg 
                245                 250                 255     


Glu Asp Gly Asn Glu Glu Asp Lys Glu Asn Gln Gly Asp Glu Thr Gln 
            260                 265                 270         


Gly Gln Gln Pro Pro Gln Arg Arg Tyr Arg Arg Asn Phe Asn Tyr Arg 
        275                 280                 285             


Arg Arg Arg Pro Glu Asn Pro Lys Pro Gln Asp Gly Lys Glu Thr Lys 
    290                 295                 300                 


Ala Ala Asp Pro Pro Ala Glu Asn Ser Ser Ala Pro Glu Ala Glu Gln 
305                 310                 315                 320 


Gly Gly Ala Glu 
                


<210>  30
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30
ttcctacttg gcagtacatc tacg                                              24


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  31
gtcaatgggg tggagacttg g                                                 21


<210>  32
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  32
tgagtcaaac cgctatccac gccca                                             25


<210>  33
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA

<400>  33
atcggcggcg cctgccggcg gtttt                                             25


<210>  34
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA

<400>  34
cgccggcagg cgccgccgat cggtg                                             25


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA

<400>  35
gtaatggctt ttgtagggtg gttt                                              24


<210>  36
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA

<400>  36
caccctacaa aagccattac cggtg                                             25


<210>  37
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA

<400>  37
ggaccatacc tgcggaatcg gtttt                                             25


<210>  38
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA

<400>  38
cgattccgca ggtatggtcc cggtg                                             25


<210>  39
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA

<400>  39
caaagacagc ctagaaggag tttt                                              24


<210>  40
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA

<400>  40
tcctctctag gctgtctttg cggtg                                             25


