                         SEQUENCE LISTING

<110>  Deakin University
 
<120>  Improved Aptamers

<130>  514814

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  locked nucleic acid guanine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl guanine

<400>  1
cccuccuaca uaggg                                                        15


<210>  2
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  unlocked nucleic acid uracil

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  inverted thymidine

<400>  2
cccuccuaca uagggt                                                       16


<210>  3
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  unlocked nucleic acid adenine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  Inverted thymidine

<400>  3
cccuccuaca uagggt                                                       16


<210>  4
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  Inverted thymidine

<400>  4
cccuccuaca uagggt                                                       16


<210>  5
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  inverted thymidine

<400>  5
cccuccuaca uagggt                                                       16


<210>  6
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  locked nucleic acid guanine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl guanine

<400>  6
ccuccuacau agg                                                          13


<210>  7
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  locked nucleic acid adenine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl guanine

<400>  7
ctccuacaua g                                                            11


<210>  8
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  locked nucleic acid adenine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl guanine

<400>  8
ctccuacaua g                                                            11


<210>  9
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  unlocked nucleic acid adenine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  locked nucleic acid adenine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl guanine

<400>  9
ctccuacaua g                                                            11


<210>  10
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  inverted thymidine

<400>  10
ccctcctaca tagggt                                                       16


<210>  11
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro uracil

<400>  11
cccuccuaca uaggg                                                        15


<210>  12
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  locked nucleic acid guanine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl guanine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  inverted thymidine

<400>  12
cccuccuaca uagggt                                                       16


<210>  13
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  unlocked nucleic acid adenine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  locked nucleic acid guanine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl guanine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  inverted thymidine

<400>  13
cccuccuaca uagggt                                                       16


<210>  14
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  unlocked nucleic acid uracil

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  locked nucleic acid guanine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl guanine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  inverted thymidine

<400>  14
cccuccuaca uagggt                                                       16


<210>  15
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  locked nucleic acid adenine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl guanine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  inverted thymidine

<400>  15
ctccuacaua gt                                                           12


<210>  16
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  unlocked nucleic acid uracil

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  locked nucleic acid adenine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl guanine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  Inverted thymidine

<400>  16
ctccuacaua gt                                                           12


<210>  17
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  Inverted thymidine

<400>  17
cccuccuaca uagggt                                                       16


<210>  18
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  locked nucleic acid adenine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  locked nucleic acid guanine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  inverted thymidine

<400>  18
ctccuacaua gt                                                           12


<210>  19
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  locked nucleic acid adenine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl guanine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  inverted thymidine

<400>  19
ctccuacaua gt                                                           12


<210>  20
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro uracil

<400>  20
cuccuacaua g                                                            11


<210>  21
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  a synthetic apatamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  unlocked nucleic acid uracil

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro uracil

<400>  21
cuccuacaua g                                                            11


<210>  22
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  locked nucleic acid adenine

<400>  22
ctccuacaua g                                                            11


<210>  23
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro uracil

<400>  23
ccuccuacau agg                                                          13


<210>  24
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  locked nucleic acid adenine

<400>  24
ctccuacaua g                                                            11


<210>  25
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  locked nucleic acid adenine

<400>  25
ctccuacaua g                                                            11


<210>  26
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against CD133


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  locked nucleic acid adenine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  locked nucleic acid guanine

<400>  26
ctccuacaua g                                                            11


<210>  27
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  concensus sequence CD133 aptamer


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro cytosine or unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro uracil or unlocked nucleic acid uracil

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  adenine or unlocked nucleic acid adenine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  guanine or locked nucleic acid guanine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl guanine

<400>  27
cccuccuaca uaggg                                                        15


<210>  28
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Concensus sequence CD133 aptamer


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro cytosine or unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro uracil or unlocked nucleic acid uracil

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  adenine or unlocked nucleic acid adenine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  locked nucleic acid adenine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  locked nucleic acid guanine or 2'-O-methyl guanine

<400>  28
ctccuacaua g                                                            11


<210>  29
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against EpCAM


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  thymine locked nucleic acid

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid guanine

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  2'-fluoro uracil

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl guanine

<400>  29
tgguuacccg                                                              10


<210>  30
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against cAMP


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid guanine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  unlocked nucleic acid adenine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  locked nucleic acid guanine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'O-methyl cytosine

<400>  30
gacuaaaacg acuuguc                                                      17


<210>  31
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against HIV


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid adenine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  locked nucleic acid guanine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  unlocked nucleic acid adenine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'O-methyl cytosine

<400>  31
tagccatctc                                                              10


<210>  32
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against ampicillin


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  locked nucleic acid guanine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  unlocked nucleic acid guanine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  unlocked nucleic acid thymine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  locked nucleic acid adenine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl guanine

<400>  32
ttggggttca g                                                            11


<210>  33
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against adrenoreceptor autoantibody


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  Locked nucleic acid adenine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  unlocked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  unlocked nucleic acid thymine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  locked nucleic acid guanine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'O-methyl cytosine

<400>  33
aaccgcgtga ggtc                                                         14


<210>  34
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a synthetic aptamer against aflatoxin


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid adenine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  locked nucleic acid cytosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  locked nucleic acid thymine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  unlocked nucleic acid adenine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  locked nucleic acid adenine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  locked nucleic acid guanine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'O-methyl adenine

<400>  34
actgctagag a                                                            11


