                         SEQUENCE LISTING

<110>  Katholieke Universiteit Leuven
       Institut National de la Sant et de la Recherche Mdicale 
       (INSERM)
       Declerck, Paul
       De Meyer, Simon
       Geukens, Nick
       Gils, Ann
       Rubio, Marina
       Vivien, Denis
       Wyseure, Tine
 
<120>  Dual targeting of TAFI and PAI-1

<130>  KUL2091PCT

<150>  US61/937,323
<151>  2014-02-07

<150>  GB1404879.7
<151>  2014-03-19

<150>  GB1404880.5
<151>  2014-03-19

<150>  GB1411979.6
<151>  2014-07-04

<150>  GB1422609.6
<151>  2014-12-18

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  1

Asp Asn Asn Met Asp 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  PRT
<222>  (2)..(2)
<223>  Xaa may be Val or Ile

<400>  2

Ser Xaa Tyr Ser Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  3

Glu Met Ser Asp Gly Pro Tyr Trp Phe Phe Asp Val 
1               5                   10          


<210>  4
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  4

Arg Ala Ser Glu Asn Ile Phe Arg Asn Leu Val 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  5

Ser Ala Thr Asn Leu Val Asp 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  6

Gln His Phe Trp Gly Thr Pro Arg Thr 
1               5                   


<210>  7
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  7

Asp Thr Tyr Ile His 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  8

Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Ser Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  9
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  9

Gly Asp Tyr Asp Tyr Val Tyr Phe Asp Tyr 
1               5                   10  


<210>  10
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  10

Arg Ala Ser Gln Asp Ile Ser Asn Phe Leu Asp 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  11

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  12

Gln Gln Gly Asn Thr Phe Pro Pro Thr 
1               5                   


<210>  13
<211>  121
<212>  PRT
<213>  Mus musculus


<220>
<221>  PEPTIDE
<222>  (51)..(51)
<223>  Xaa may be Val or Ile

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asn 
            20                  25                  30          


Asn Met Asp Trp Ala Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Xaa Tyr Ser Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Asn Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Ser Asp Gly Pro Tyr Trp Phe Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Gly 
        115                 120     


<210>  14
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Phe Arg Asn 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ser Ala Thr Asn Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  15
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  15

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ala Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Gly Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Ser Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Asp Tyr Asp Tyr Val Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  16
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Phe 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Lys Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  17
<211>  266
<212>  PRT
<213>  Mus musculus

<400>  17

Met Ala Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Asp Asn Asn Met Asp Trp Ala Lys Gln Ser His Gly Lys Ser Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Ser Asn Asn Gly Gly Thr Ile Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Lys Gly Lys Ala Thr Leu Asn Val Asp Thr Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Glu Met Ser Asp Gly Pro Tyr Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Gly Ala Lys Thr Thr Pro 
        115                 120                 125             


Lys Leu Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    130                 135                 140                 


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
145                 150                 155                 160 


Ile Ser Asn Phe Leu Asp Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
                165                 170                 175     


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
        195                 200                 205             


Lys Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
    210                 215                 220                 


Thr Phe Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 235                 240 


Ala Asp Ala Ala Ala Ala Gly Ser Glu Gln Lys Leu Ile Ser Glu Glu 
                245                 250                 255     


Asp Leu Asn Ser His His His His His His 
            260                 265     


<210>  18
<211>  264
<212>  PRT
<213>  Mus musculus

<400>  18

Met Ala Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Leu Ala Cys Thr Ala Ser Gly Phe Asn Ile Lys 
            20                  25                  30          


Asp Thr Tyr Ile His Trp Val Lys Gln Gly Pro Glu Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Ser 
    50                  55                  60                  


Lys Phe Gln Asp Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Asp Tyr Asp Tyr Val Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Lys Leu 
        115                 120                 125             


Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser 
    130                 135                 140                 


Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Phe 
145                 150                 155                 160 


Arg Asn Leu Val Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu 
                165                 170                 175     


Leu Val Tyr Ser Ala Thr Asn Leu Val Asp Gly Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu 
        195                 200                 205             


Gln Ser Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly Thr 
    210                 215                 220                 


Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp 
225                 230                 235                 240 


Thr Ala Pro Thr Gly Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                245                 250                 255     


Asn Ser His His His His His His 
            260                 


