                         SEQUENCE LISTING

<110>  Zamiri, Parisa
       He, Yunsheng
       Li, Yue
 
<120>  IMPACT OF GENETIC FACTORS ON DISEASE PROGRESSION AND RESPONSE TO 
       ANTI-C5 ANTIBODY IN GEOGRAPHIC ATROPHY

<130>  PAT055892-WO-PCT

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  1001
<212>  DNA
<213>  Homo sapiens


<220>
<221>  variation
<222>  (1)..(1001)
<223>  Age-related maculopathy susceptibility 2 (ARMS2), rs10490924 
       |allelePos=501|alleles='G/T'.  T is the risk allele.

<220>
<221>  variation
<222>  (501)..(501)
<223>  T is the risk allele.

<400>  1
tacaatcaag gttttttttt tttttcaaat ccctgggtct ctgcattttt taaaagcttc       60

acagatgatt tcaatggata ctagggacct ctgttgcctc ctctggcaga gcaggactga      120

ggggtggacc ctccctgaga ccacccaaca attcagggtg gagttatcag ggcgccctga      180

ctcctggggg catttttgtg tgacgggaaa agacaatgct cctggctgag tgagatggca      240

gctggcttgg caaggggaca gcacctttgt caccacatta tgtccctgta ccctacatgc      300

tgcgcctata cccaggaccg atggtaactg aggcggaggg gaaaggaggg cctgagatgg      360

caagtctgtc ctcctcggtg gttcctgtgt ccttcatttc cactctgcga gagtctgtgc      420

tggaccctgg agttggtgga gaaggagcca gtgacaagca gaggagcaaa ctgtctttat      480

cacactccat gatcccagct tctaaaatcc acactgagct ctgcttacca gccttcttct      540

ctcctgctgg aacccagagg aggttccagc agcctcagca ccacctgaca ctggtaagaa      600

atgcagatga tcaggcctta ccccagacct attgaatcag aaattctgga gtggtgccct      660

gcagcttgca ttttaaccag ccttcaggtg cttctgatgc atgctcaggt ttgagcacca      720

ctggccacag ggaggcctag gcaattcagc cttcctctgg ttgaatagct ggagaattgg      780

gaatatcagt aaatacttcc aatgcacctg ctacatgcca gaaaaaggaa acaagaagac      840

gcagtaggtc tgagaaagtg atggggtgag cagaaaccca aagcttatag aaggccatct      900

gagtggcccc tcaagccggt gaattggctt tagggtttac tgaaggaggt ggaaacctca      960

gcctgcttct cgtccgggtt gttagaggag tcatttagaa a                         1001


<210>  2
<211>  501
<212>  DNA
<213>  Homo sapiens


<220>
<221>  variation
<222>  (1)..(501)
<223>  HtrA serine peptidase 1 (HTRA1) 
       rs11200638|allelePos=251|alleles='A/G' 

G is the risk allele.

<220>
<221>  variation
<222>  (251)..(251)
<223>  G is the risk allele.

<400>  2
tggtgaaaaa tcaaaagagg ggaaaacccc tttcccatct gagaccgctc caccctcgcc       60

agttacgagc tgccgagccg cttcctaggc tctctgcgaa tacggacacg catgccaccc      120

acaacaactt tttaaaagaa tcagacgtgt gaaggattct attcgaatta cttctgctct      180

ctgcttttat cacttcactg tgggtctggg cgcgggcttt ctgccagctc cgcggacgct      240

gccttcgtcc ggccgcagag gccccgcggt cagggtcccg cgtgcggggt accgggggca      300

gaaccagcgc gtgaccgggg tccgcggtgc cgcaacgccc cgggtctgcg cagaggcccc      360

tgcagtccct gcccggccca gtccgagctt cccgggcggg cccccagtcc ggcgatttgc      420

aggaactttc cccggcgctc ccacgcgaag ccgccgcagg gcccccttgc aaagttccat      480

tagtttgaag gacgcgaatc t                                                501


<210>  3
<211>  1001
<212>  DNA
<213>  Homo sapiens


<220>
<221>  variation
<222>  (1)..(1001)
<223>  Complement factor H (CFH) rs1061170|allelePos=501|alleles='C/T'. 
       C is the risk allele.

<220>
<221>  variation
<222>  (501)..(501)
<223>  C is the risk allele.

<400>  3
atgcctcagt aagtaaacct ctgaactgct atatatatgt ataaaacttt caaagatcga       60

agaaaggaga gcacataagt gattacacct gtcttatgta acagaaatag ggccaagaaa      120

agagttgttc aagcaaagtg accaaaatag atcttttcta ttatgagggt ttcttcttga      180

aaatcacagg agaaataaat atagggactt tatgagaata tctatataat ttatacatct      240

attaattata aaaactaaag ataagtaata ttgaatattg atatttcttt ttgtgcaaac      300

ctttgttagt aactttagtt cgtcttcagt tatacattat ttttggatgt ttatgcaatc      360

ttatttaaat attgtaaaaa taattgtaat atactatttt gagcaaattt atgtttctca      420

tttactttat ttatttatca ttgttatggt ccttaggaaa atgttatttt ccttatttgg      480

aaaatggata taatcaaaat catggaagaa agtttgtaca gggtaaatct atagacgttg      540

cctgccatcc tggctacgct cttccaaaag cgcagaccac agttacatgt atggagaatg      600

gctggtctcc tactcccaga tgcatccgtg tcagtaagta cactactctg aaatcctagc      660

atgttcatgt ctttctaagt aacatagatg acattctaag actcatctat attaattgtg      720

gcaaaatgtt tatgtcacct tgttttacca atggacctat ttagtttttg gtttttcaac      780

tgtgtataaa tgaatataca aatttcttga taagtacata gtaaaataaa ttctcctatt      840

aatgggcatt agtcaagaat acagtaaaag aatttgaaca caatacttgt tggttaaatg      900

aagtcgtatt gaagcggcat cattgtctgg gtaaatatct gaggttcgtt atctcacacc      960

aagaagatta aggacgtgga cacacacaag gagtgagttt a                         1001


<210>  4
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(5)
<223>  Antibody 8109, HCDR1

<400>  4

Ser Tyr Ala Ile Ser 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(17)
<223>  Antibody 8109, HCDR2 domain

<400>  5

Gly Ile Gly Pro Phe Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  Antibody 8109, HCDR3

<400>  6

Asp Thr Pro Tyr Phe Asp Tyr 
1               5           


<210>  7
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Antibody 8109, LCDR1 domain

<400>  7

Ser Gly Asp Ser Ile Pro Asn Tyr Tyr Val Tyr 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  Antibody 8109, LCDR2

<400>  8

Asp Asp Ser Asn Arg Pro Ser 
1               5           


<210>  9
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Antibody 8109, LCDR3

<400>  9

Gln Ser Phe Asp Ser Ser Leu Asn Ala Glu Val 
1               5                   10      


