                         SEQUENCE LISTING

<110>  ABBOTT LABORATORIES
 
<120>  NOVEL ASSAY TO DETECT HUMAN PERIOSTIN

<130>  029996-1906-WO00 & WO01

<140>  New PCT International Patent Application
<141>  2015-02-05

<150>  US 61/936,967
<151>  2014-02-07

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Thr Thr Lys 
            660                 665                 670         


Ile Ile Thr Lys Val Val Glu Pro Lys Ile Lys Val Ile Glu Gly Ser 
        675                 680                 685             


Leu Gln Pro Ile Ile Lys Thr Glu Gly Pro Thr Leu Thr Lys Val Lys 
    690                 695                 700                 


Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys Glu Gly Glu Thr Ile 
705                 710                 715                 720 


Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys Lys Tyr Thr Lys Ile 
                725                 730                 735     


Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys Glu Thr Arg Glu Glu 
            740                 745                 750         


Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr Arg Ile Ser Thr Gly 
        755                 760                 765             


Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu Leu Gln Glu Glu Val 
    770                 775                 780                 


Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp Gly His Leu Phe Glu 
785                 790                 795                 800 


Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp Thr Pro Val Arg Lys 
                805                 810                 815     


Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu 
            820                 825                 830         


Gly Arg Ser Gln 
        835     


<210>  2
<211>  779
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Lys Pro Ile 
            660                 665                 670         


Ile Lys Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr 
        675                 680                 685             


Glu Lys Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys 
    690                 695                 700                 


Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys 
705                 710                 715                 720 


Lys Leu Leu Gln Glu Glu Val Thr Lys Val Thr Lys Phe Ile Glu Gly 
                725                 730                 735     


Gly Asp Gly His Leu Phe Glu Asp Glu Glu Ile Lys Arg Leu Leu Gln 
            740                 745                 750         


Gly Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val Gln Gly 
        755                 760                 765             


Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
    770                 775                 


<210>  3
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Arg Pro Thr 
            660                 665                 670         


Leu Thr Lys Val Lys Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys 
        675                 680                 685             


Glu Gly Glu Thr Ile Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys 
    690                 695                 700                 


Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys 
705                 710                 715                 720 


Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr 
                725                 730                 735     


Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu 
            740                 745                 750         


Leu Gln Glu Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val 
        755                 760                 765             


Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
    770                 775                 780     


<210>  4
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Lys Pro Ile 
            660                 665                 670         


Ile Lys Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr 
        675                 680                 685             


Glu Lys Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys 
    690                 695                 700                 


Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys 
705                 710                 715                 720 


Lys Leu Leu Gln Glu Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys 
                725                 730                 735     


Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
            740                 745                 750     


<210>  5
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mature N-terminal region common to the four periostin isoforms

<400>  5

Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser Arg Ile Arg Gly Arg 
1               5                   10                  15      


Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln Ile Leu Gly Thr Lys 
            20                  25                  30          


Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr Lys Lys Ser Ile Cys 
        35                  40                  45              


Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys Pro Gly Tyr Met Arg 
    50                  55                  60                  


Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu Pro Ile Asp His Val 
65                  70                  75                  80  


Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr Thr Gln Arg Tyr Ser 
                85                  90                  95      


Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly Lys Gly Ser Phe Thr 
            100                 105                 110         


Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn Leu Asp Ser Asp Ile 
        115                 120                 125             


Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu Leu Leu Asn Ala Leu 
    130                 135                 140                 


His Ser His Met Ile Asn Lys Arg Met Leu Thr Lys Asp Leu Lys Asn 
145                 150                 155                 160 


Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu Gly Leu Phe Ile Asn 
                165                 170                 175     


His Tyr Pro Asn Gly Val Val Thr Val Asn Cys Ala Arg Ile Ile His 
            180                 185                 190         


Gly Asn Gln Ile Ala Thr Asn Gly Val Val His Val Ile Asp Arg Val 
        195                 200                 205             


Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe Ile Glu Ala Glu Asp 
    210                 215                 220                 


Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr Ser Asp Ile Leu Glu 
225                 230                 235                 240 


Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe Ala Pro Thr Asn Glu 
                245                 250                 255     


Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu Arg Ile Met Gly Asp 
            260                 265                 270         


Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His Ile Leu Asn Thr Leu 
        275                 280                 285             


Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val Phe Glu Thr Leu Glu 
    290                 295                 300                 


Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp Ser Ile Thr Val Asn 
305                 310                 315                 320 


Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val Thr Asn Asn Gly Val 
                325                 330                 335     


Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp Ser Ala Lys Gln Val 
            340                 345                 350         


Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe Thr Asp Leu Val Ala 
        355                 360                 365             


Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp Gly Glu Tyr Thr Leu 
    370                 375                 380                 


Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp Thr Leu Ser Met Asp 
385                 390                 395                 400 


Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His Ile Leu Lys Val Lys 
                405                 410                 415     


Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile Leu Glu Thr Ile Gly 
            420                 425                 430         


Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr Ala Val Cys Ile Glu 
        435                 440                 445             


Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly Arg Asn Gly Ala Ile 
    450                 455                 460                 


His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu Lys Ser Leu His Glu 
465                 470                 475                 480 


Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe Leu Ser Leu Leu Glu 
                485                 490                 495     


Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro Gly Asp Trp Thr Leu 
            500                 505                 510         


Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met Thr Ser Glu Glu Lys 
        515                 520                 525             


Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln Asn Ile Ile Leu Tyr 
    530                 535                 540                 


His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly Phe Glu Pro Gly Val 
545                 550                 555                 560 


Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys Ile Phe Leu Lys Glu 
                565                 570                 575     


Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys Ser Lys Glu Ser Asp 
            580                 585                 590         


Ile Met Thr Thr Asn Gly Val Ile His Val Val Asp Lys Leu Leu Tyr 
        595                 600                 605             


Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu Leu Glu Ile Leu Asn 
    610                 615                 620                 


Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val Arg Gly Ser Thr Phe 
625                 630                 635                 640 


Lys Glu Ile Pro Val Thr Val Tyr Gly Gly Ser Gly Gly His His His 
                645                 650                 655     


His His His 
            


<210>  6
<211>  445
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(445)
<223>  Lebrikizumab Heavy chain

<400>  6

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr 
            20                  25                  30          


Ser Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Met Ile Trp Gly Asp Gly Lys Ile Val Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Asp Gly Tyr Tyr Pro Tyr Ala Met Asp Asn Trp Gly Gln Gly Ser 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  7
<211>  218
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(218)
<223>  Lebrikizumab Light chain

<400>  7

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  8
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  Tralokinumab Heavy chain

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  9
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(108)
<223>  Tralokinumab Light chain

<400>  9

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  10
<211>  2563
<212>  DNA
<213>  Homo sapiens

<400>  10
ggcgcgccgc accatgattc cctttttacc catgttttct ctactattgc tgcttattgt       60

taaccctata aacgccaaca atcattatga caagatcttg gctcatagtc gtatcagggg      120

tcgggaccaa ggcccaaatg tctgtgccct tcaacagatt ttgggcacca aaaagaaata      180

cttcagcact tgtaagaact ggtataaaaa gtccatctgt ggacagaaaa cgactgtgtt      240

atatgaatgt tgccctggtt atatgagaat ggaaggaatg aaaggctgcc cagcagtttt      300

gcccattgac catgtttatg gcactctggg catcgtggga gccaccacaa cgcagcgcta      360

ttctgacgcc tcaaaactga gggaggagat cgagggaaag ggatccttca cttactttgc      420

accgagtaat gaggcttggg acaacttgga ttctgatatc cgtagaggtt tggagagcaa      480

cgtgaatgtt gaattactga atgctttaca tagtcacatg attaataaga gaatgttgac      540

caaggactta aaaaatggca tgattattcc ttcaatgtat aacaatttgg ggcttttcat      600

taaccattat cctaatgggg ttgtcactgt taattgtgct cgaatcatcc atgggaacca      660

gattgcaaca aatggtgttg tccatgtcat tgaccgtgtg cttacacaaa ttggtacctc      720

aattcaagac ttcattgaag cagaagatga cctttcatct tttagagcag ctgccatcac      780

atcggacata ttggaggccc ttggaagaga cggtcacttc acactctttg ctcccaccaa      840

tgaggctttt gagaaacttc cacgaggtgt cctagaaagg atcatgggag acaaagtggc      900

ttccgaagct cttatgaagt accacatctt aaatactctc cagtgttctg agtctattat      960

gggaggagca gtctttgaga cgctggaagg aaatacaatt gagataggat gtgacggtga     1020

cagtataaca gtaaatggaa tcaaaatggt gaacaaaaag gatattgtga caaataatgg     1080

tgtgatccat ttgattgatc aggtcctaat tcctgattct gccaaacaag ttattgagct     1140

ggctggaaaa cagcaaacca ccttcacgga tcttgtggcc caattaggct tggcatctgc     1200

tctgaggcca gatggagaat acactttgct ggcacctgtg aataatgcat tttctgatga     1260

tactctcagc atggatcagc gcctccttaa attaattctg cagaatcaca tattgaaagt     1320

aaaagttggc cttaatgagc tttacaacgg gcaaatactg gaaaccatcg gaggcaaaca     1380

gctcagagtc ttcgtatatc gtacagctgt ctgcattgaa aattcatgca tggagaaagg     1440

gagtaagcaa gggagaaacg gtgcgattca catattccgc gagatcatca agccagcaga     1500

gaaatccctc catgaaaagt taaaacaaga taagcgcttt agcaccttcc tcagcctact     1560

tgaagctgca gacttgaaag agctcctgac acaacctgga gactggacat tatttgtgcc     1620

aaccaatgat gcttttaagg gaatgactag tgaagaaaaa gaaattctga tacgggacaa     1680

aaatgctctt caaaacatca ttctttatca cctgacacca ggagttttca ttggaaaagg     1740

atttgaacct ggtgttacta acattttaaa gaccacacaa ggaagcaaaa tctttctgaa     1800

agaagtaaat gatacacttc tggtgaatga attgaaatca aaagaatctg acatcatgac     1860

aacaaatggt gtaattcatg ttgtagataa actcctctat ccagcagaca cacctgttgg     1920

aaatgatcaa ctgctggaaa tacttaataa attaatcaaa tacatccaaa ttaagtttgt     1980

tcgtggtagc accttcaaag aaatccccgt gactgtctat acaactaaaa ttataaccaa     2040

agttgtggaa ccaaaaatta aagtgattga aggcagtctt cagcctatta tcaaaactga     2100

aggacccaca ctaacaaaag tcaaaattga aggtgaacct gaattcagac tgattaaaga     2160

aggtgaaaca ataactgaag tgatccatgg agagccaatt attaaaaaat acaccaaaat     2220

cattgatgga gtgcctgtgg aaataactga aaaagagaca cgagaagaac gaatcattac     2280

aggtcctgaa ataaaataca ctaggatttc tactggaggt ggagaaacag aagaaactct     2340

gaagaaattg ttacaagaag aggtcaccaa ggtcaccaaa ttcattgaag gtggtgatgg     2400

tcatttattt gaagatgaag aaattaaaag actgcttcag ggagacacac ccgtgaggaa     2460

gttgcaagcc aacaaaaaag ttcaaggatc tagaagacga ttaagggaag gtcgttctca     2520

ggggtctggc tcaggacacc atcatcacca tcatcaccac taa                       2563


<210>  11
<211>  2392
<212>  DNA
<213>  Homo sapiens

<400>  11
ggcgcgccgc accatgattc cctttttacc catgttttct ctactattgc tgcttattgt       60

taaccctata aacgccaaca atcattatga caagatcttg gctcatagtc gtatcagggg      120

tcgggaccaa ggcccaaatg tctgtgccct tcaacagatt ttgggcacca aaaagaaata      180

cttcagcact tgtaagaact ggtataaaaa gtccatctgt ggacagaaaa cgactgtgtt      240

atatgaatgt tgccctggtt atatgagaat ggaaggaatg aaaggctgcc cagcagtttt      300

gcccattgac catgtttatg gcactctggg catcgtggga gccaccacaa cgcagcgcta      360

ttctgacgcc tcaaaactga gggaggagat cgagggaaag ggatccttca cttactttgc      420

accgagtaat gaggcttggg acaacttgga ttctgatatc cgtagaggtt tggagagcaa      480

cgtgaatgtt gaattactga atgctttaca tagtcacatg attaataaga gaatgttgac      540

caaggactta aaaaatggca tgattattcc ttcaatgtat aacaatttgg ggcttttcat      600

taaccattat cctaatgggg ttgtcactgt taattgtgct cgaatcatcc atgggaacca      660

gattgcaaca aatggtgttg tccatgtcat tgaccgtgtg cttacacaaa ttggtacctc      720

aattcaagac ttcattgaag cagaagatga cctttcatct tttagagcag ctgccatcac      780

atcggacata ttggaggccc ttggaagaga cggtcacttc acactctttg ctcccaccaa      840

tgaggctttt gagaaacttc cacgaggtgt cctagaaagg atcatgggag acaaagtggc      900

ttccgaagct cttatgaagt accacatctt aaatactctc cagtgttctg agtctattat      960

gggaggagca gtctttgaga cgctggaagg aaatacaatt gagataggat gtgacggtga     1020

cagtataaca gtaaatggaa tcaaaatggt gaacaaaaag gatattgtga caaataatgg     1080

tgtgatccat ttgattgatc aggtcctaat tcctgattct gccaaacaag ttattgagct     1140

ggctggaaaa cagcaaacca ccttcacgga tcttgtggcc caattaggct tggcatctgc     1200

tctgaggcca gatggagaat acactttgct ggcacctgtg aataatgcat tttctgatga     1260

tactctcagc atggatcagc gcctccttaa attaattctg cagaatcaca tattgaaagt     1320

aaaagttggc cttaatgagc tttacaacgg gcaaatactg gaaaccatcg gaggcaaaca     1380

gctcagagtc ttcgtatatc gtacagctgt ctgcattgaa aattcatgca tggagaaagg     1440

gagtaagcaa gggagaaacg gtgcgattca catattccgc gagatcatca agccagcaga     1500

gaaatccctc catgaaaagt taaaacaaga taagcgcttt agcaccttcc tcagcctact     1560

tgaagctgca gacttgaaag agctcctgac acaacctgga gactggacat tatttgtgcc     1620

aaccaatgat gcttttaagg gaatgactag tgaagaaaaa gaaattctga tacgggacaa     1680

aaatgctctt caaaacatca ttctttatca cctgacacca ggagttttca ttggaaaagg     1740

atttgaacct ggtgttacta acattttaaa gaccacacaa ggaagcaaaa tctttctgaa     1800

agaagtaaat gatacacttc tggtgaatga attgaaatca aaagaatctg acatcatgac     1860

aacaaatggt gtaattcatg ttgtagataa actcctctat ccagcagaca cacctgttgg     1920

aaatgatcaa ctgctggaaa tacttaataa attaatcaaa tacatccaaa ttaagtttgt     1980

tcgtggtagc accttcaaag aaatccccgt gactgtctat aagccaatta ttaaaaaata     2040

caccaaaatc attgatggag tgcctgtgga aataactgaa aaagagacac gagaagaacg     2100

aatcattaca ggtcctgaaa taaaatacac taggatttct actggaggtg gagaaacaga     2160

agaaactctg aagaaattgt tacaagaaga ggtcaccaag gtcaccaaat tcattgaagg     2220

tggtgatggt catttatttg aagatgaaga aattaaaaga ctgcttcagg gagacacacc     2280

cgtgaggaag ttgcaagcca acaaaaaagt tcaaggatct agaagacgat taagggaagg     2340

tcgttctcag gggtctggct caggacacca tcatcaccat catcaccact aa             2392


<210>  12
<211>  2398
<212>  DNA
<213>  Homo sapiens

<400>  12
ggcgcgccgc accatgattc cctttttacc catgttttct ctactattgc tgcttattgt       60

taaccctata aacgccaaca atcattatga caagatcttg gctcatagtc gtatcagggg      120

tcgggaccaa ggcccaaatg tctgtgccct tcaacagatt ttgggcacca aaaagaaata      180

cttcagcact tgtaagaact ggtataaaaa gtccatctgt ggacagaaaa cgactgtgtt      240

atatgaatgt tgccctggtt atatgagaat ggaaggaatg aaaggctgcc cagcagtttt      300

gcccattgac catgtttatg gcactctggg catcgtggga gccaccacaa cgcagcgcta      360

ttctgacgcc tcaaaactga gggaggagat cgagggaaag ggatccttca cttactttgc      420

accgagtaat gaggcttggg acaacttgga ttctgatatc cgtagaggtt tggagagcaa      480

cgtgaatgtt gaattactga atgctttaca tagtcacatg attaataaga gaatgttgac      540

caaggactta aaaaatggca tgattattcc ttcaatgtat aacaatttgg ggcttttcat      600

taaccattat cctaatgggg ttgtcactgt taattgtgct cgaatcatcc atgggaacca      660

gattgcaaca aatggtgttg tccatgtcat tgaccgtgtg cttacacaaa ttggtacctc      720

aattcaagac ttcattgaag cagaagatga cctttcatct tttagagcag ctgccatcac      780

atcggacata ttggaggccc ttggaagaga cggtcacttc acactctttg ctcccaccaa      840

tgaggctttt gagaaacttc cacgaggtgt cctagaaagg atcatgggag acaaagtggc      900

ttccgaagct cttatgaagt accacatctt aaatactctc cagtgttctg agtctattat      960

gggaggagca gtctttgaga cgctggaagg aaatacaatt gagataggat gtgacggtga     1020

cagtataaca gtaaatggaa tcaaaatggt gaacaaaaag gatattgtga caaataatgg     1080

tgtgatccat ttgattgatc aggtcctaat tcctgattct gccaaacaag ttattgagct     1140

ggctggaaaa cagcaaacca ccttcacgga tcttgtggcc caattaggct tggcatctgc     1200

tctgaggcca gatggagaat acactttgct ggcacctgtg aataatgcat tttctgatga     1260

tactctcagc atggatcagc gcctccttaa attaattctg cagaatcaca tattgaaagt     1320

aaaagttggc cttaatgagc tttacaacgg gcaaatactg gaaaccatcg gaggcaaaca     1380

gctcagagtc ttcgtatatc gtacagctgt ctgcattgaa aattcatgca tggagaaagg     1440

gagtaagcaa gggagaaacg gtgcgattca catattccgc gagatcatca agccagcaga     1500

gaaatccctc catgaaaagt taaaacaaga taagcgcttt agcaccttcc tcagcctact     1560

tgaagctgca gacttgaaag agctcctgac acaacctgga gactggacat tatttgtgcc     1620

aaccaatgat gcttttaagg gaatgactag tgaagaaaaa gaaattctga tacgggacaa     1680

aaatgctctt caaaacatca ttctttatca cctgacacca ggagttttca ttggaaaagg     1740

atttgaacct ggtgttacta acattttaaa gaccacacaa ggaagcaaaa tctttctgaa     1800

agaagtaaat gatacacttc tggtgaatga attgaaatca aaagaatctg acatcatgac     1860

aacaaatggt gtaattcatg ttgtagataa actcctctat ccagcagaca cacctgttgg     1920

aaatgatcaa ctgctggaaa tacttaataa attaatcaaa tacatccaaa ttaagtttgt     1980

tcgtggtagc accttcaaag aaatccccgt gactgtctat agacccacac taacaaaagt     2040

caaaattgaa ggtgaacctg aattcagact gattaaagaa ggtgaaacaa taactgaagt     2100

gatccatgga gagccaatta ttaaaaaata caccaaaatc attgatggag tgcctgtgga     2160

aataactgaa aaagagacac gagaagaacg aatcattaca ggtcctgaaa taaaatacac     2220

taggatttct actggaggtg gagaaacaga agaaactctg aagaaattgt tacaagaaga     2280

cacacccgtg aggaagttgc aagccaacaa aaaagttcaa ggatctagaa gacgattaag     2340

ggaaggtcgt tctcaggggt ctggctcagg acaccatcat caccatcatc accactaa       2398


<210>  13
<211>  2308
<212>  DNA
<213>  Homo sapiens

<400>  13
ggcgcgccgc accatgattc cctttttacc catgttttct ctactattgc tgcttattgt       60

taaccctata aacgccaaca atcattatga caagatcttg gctcatagtc gtatcagggg      120

tcgggaccaa ggcccaaatg tctgtgccct tcaacagatt ttgggcacca aaaagaaata      180

cttcagcact tgtaagaact ggtataaaaa gtccatctgt ggacagaaaa cgactgtgtt      240

atatgaatgt tgccctggtt atatgagaat ggaaggaatg aaaggctgcc cagcagtttt      300

gcccattgac catgtttatg gcactctggg catcgtggga gccaccacaa cgcagcgcta      360

ttctgacgcc tcaaaactga gggaggagat cgagggaaag ggatccttca cttactttgc      420

accgagtaat gaggcttggg acaacttgga ttctgatatc cgtagaggtt tggagagcaa      480

cgtgaatgtt gaattactga atgctttaca tagtcacatg attaataaga gaatgttgac      540

caaggactta aaaaatggca tgattattcc ttcaatgtat aacaatttgg ggcttttcat      600

taaccattat cctaatgggg ttgtcactgt taattgtgct cgaatcatcc atgggaacca      660

gattgcaaca aatggtgttg tccatgtcat tgaccgtgtg cttacacaaa ttggtacctc      720

aattcaagac ttcattgaag cagaagatga cctttcatct tttagagcag ctgccatcac      780

atcggacata ttggaggccc ttggaagaga cggtcacttc acactctttg ctcccaccaa      840

tgaggctttt gagaaacttc cacgaggtgt cctagaaagg atcatgggag acaaagtggc      900

ttccgaagct cttatgaagt accacatctt aaatactctc cagtgttctg agtctattat      960

gggaggagca gtctttgaga cgctggaagg aaatacaatt gagataggat gtgacggtga     1020

cagtataaca gtaaatggaa tcaaaatggt gaacaaaaag gatattgtga caaataatgg     1080

tgtgatccat ttgattgatc aggtcctaat tcctgattct gccaaacaag ttattgagct     1140

ggctggaaaa cagcaaacca ccttcacgga tcttgtggcc caattaggct tggcatctgc     1200

tctgaggcca gatggagaat acactttgct ggcacctgtg aataatgcat tttctgatga     1260

tactctcagc atggatcagc gcctccttaa attaattctg cagaatcaca tattgaaagt     1320

aaaagttggc cttaatgagc tttacaacgg gcaaatactg gaaaccatcg gaggcaaaca     1380

gctcagagtc ttcgtatatc gtacagctgt ctgcattgaa aattcatgca tggagaaagg     1440

gagtaagcaa gggagaaacg gtgcgattca catattccgc gagatcatca agccagcaga     1500

gaaatccctc catgaaaagt taaaacaaga taagcgcttt agcaccttcc tcagcctact     1560

tgaagctgca gacttgaaag agctcctgac acaacctgga gactggacat tatttgtgcc     1620

aaccaatgat gcttttaagg gaatgactag tgaagaaaaa gaaattctga tacgggacaa     1680

aaatgctctt caaaacatca ttctttatca cctgacacca ggagttttca ttggaaaagg     1740

atttgaacct ggtgttacta acattttaaa gaccacacaa ggaagcaaaa tctttctgaa     1800

agaagtaaat gatacacttc tggtgaatga attgaaatca aaagaatctg acatcatgac     1860

aacaaatggt gtaattcatg ttgtagataa actcctctat ccagcagaca cacctgttgg     1920

aaatgatcaa ctgctggaaa tacttaataa attaatcaaa tacatccaaa ttaagtttgt     1980

tcgtggtagc accttcaaag aaatccccgt gactgtctat aagccaatta ttaaaaaata     2040

caccaaaatc attgatggag tgcctgtgga aataactgaa aaagagacac gagaagaacg     2100

aatcattaca ggtcctgaaa taaaatacac taggatttct actggaggtg gagaaacaga     2160

agaaactctg aagaaattgt tacaagaaga cacacccgtg aggaagttgc aagccaacaa     2220

aaaagttcaa ggatctagaa gacgattaag ggaaggtcgt tctcaggggt ctggctcagg     2280

acaccatcat caccatcatc accactaa                                        2308


<210>  14
<211>  2302
<212>  DNA
<213>  Homo sapiens

<400>  14
ggcgcgccgc accatgattc cctttttacc catgttttct ctactattgc tgcttattgt       60

taaccctata aacgccaaca atcattatga caagatcttg gctcatagtc gtatcagggg      120

tcgggaccaa ggcccaaatg tctgtgccct tcaacagatt ttgggcacca aaaagaaata      180

cttcagcact tgtaagaact ggtataaaaa gtccatctgt ggacagaaaa cgactgtgtt      240

atatgaatgt tgccctggtt atatgagaat ggaaggaatg aaaggctgcc cagcagtttt      300

gcccattgac catgtttatg gcactctggg catcgtggga gccaccacaa cgcagcgcta      360

ttctgacgcc tcaaaactga gggaggagat cgagggaaag ggatccttca cttactttgc      420

accgagtaat gaggcttggg acaacttgga ttctgatatc cgtagaggtt tggagagcaa      480

cgtgaatgtt gaattactga atgctttaca tagtcacatg attaataaga gaatgttgac      540

caaggactta aaaaatggca tgattattcc ttcaatgtat aacaatttgg ggcttttcat      600

taaccattat cctaatgggg ttgtcactgt taattgtgct cgaatcatcc atgggaacca      660

gattgcaaca aatggtgttg tccatgtcat tgaccgtgtg cttacacaaa ttggtacctc      720

aattcaagac ttcattgaag cagaagatga cctttcatct tttagagcag ctgccatcac      780

atcggacata ttggaggccc ttggaagaga cggtcacttc acactctttg ctcccaccaa      840

tgaggctttt gagaaacttc cacgaggtgt cctagaaagg atcatgggag acaaagtggc      900

ttccgaagct cttatgaagt accacatctt aaatactctc cagtgttctg agtctattat      960

gggaggagca gtctttgaga cgctggaagg aaatacaatt gagataggat gtgacggtga     1020

cagtataaca gtaaatggaa tcaaaatggt gaacaaaaag gatattgtga caaataatgg     1080

tgtgatccat ttgattgatc aggtcctaat tcctgattct gccaaacaag ttattgagct     1140

ggctggaaaa cagcaaacca ccttcacgga tcttgtggcc caattaggct tggcatctgc     1200

tctgaggcca gatggagaat acactttgct ggcacctgtg aataatgcat tttctgatga     1260

tactctcagc atggatcagc gcctccttaa attaattctg cagaatcaca tattgaaagt     1320

aaaagttggc cttaatgagc tttacaacgg gcaaatactg gaaaccatcg gaggcaaaca     1380

gctcagagtc ttcgtatatc gtacagctgt ctgcattgaa aattcatgca tggagaaagg     1440

gagtaagcaa gggagaaacg gtgcgattca catattccgc gagatcatca agccagcaga     1500

gaaatccctc catgaaaagt taaaacaaga taagcgcttt agcaccttcc tcagcctact     1560

tgaagctgca gacttgaaag agctcctgac acaacctgga gactggacat tatttgtgcc     1620

aaccaatgat gcttttaagg gaatgactag tgaagaaaaa gaaattctga tacgggacaa     1680

aaatgctctt caaaacatca ttctttatca cctgacacca ggagttttca ttggaaaagg     1740

atttgaacct ggtgttacta acattttaaa gaccacacaa ggaagcaaaa tctttctgaa     1800

agaagtaaat gatacacttc tggtgaatga attgaaatca aaagaatctg acatcatgac     1860

aacaaatggt gtaattcatg ttgtagataa actcctctat ccagcagaca cacctgttgg     1920

aaatgatcaa ctgctggaaa tacttaataa attaatcaaa tacatccaaa ttaagtttgt     1980

tcgtggtagc accttcaaag aaatccccgt gactgtctat ggtcctgaaa taaaatacac     2040

taggatttct actggaggtg gagaaacaga agaaactctg aagaaattgt tacaagaaga     2100

ggtcaccaag gtcaccaaat tcattgaagg tggtgatggt catttatttg aagatgaaga     2160

aattaaaaga ctgcttcagg gagacacacc cgtgaggaag ttgcaagcca acaaaaaagt     2220

tcaaggatct agaagacgat taagggaagg tcgttctcag gggtctggct caggacacca     2280

tcatcaccat catcaccact aa                                              2302


<210>  15
<211>  2212
<212>  DNA
<213>  Homo sapiens

<400>  15
ggcgcgccgc accatgattc cctttttacc catgttttct ctactattgc tgcttattgt       60

taaccctata aacgccaaca atcattatga caagatcttg gctcatagtc gtatcagggg      120

tcgggaccaa ggcccaaatg tctgtgccct tcaacagatt ttgggcacca aaaagaaata      180

cttcagcact tgtaagaact ggtataaaaa gtccatctgt ggacagaaaa cgactgtgtt      240

atatgaatgt tgccctggtt atatgagaat ggaaggaatg aaaggctgcc cagcagtttt      300

gcccattgac catgtttatg gcactctggg catcgtggga gccaccacaa cgcagcgcta      360

ttctgacgcc tcaaaactga gggaggagat cgagggaaag ggatccttca cttactttgc      420

accgagtaat gaggcttggg acaacttgga ttctgatatc cgtagaggtt tggagagcaa      480

cgtgaatgtt gaattactga atgctttaca tagtcacatg attaataaga gaatgttgac      540

caaggactta aaaaatggca tgattattcc ttcaatgtat aacaatttgg ggcttttcat      600

taaccattat cctaatgggg ttgtcactgt taattgtgct cgaatcatcc atgggaacca      660

gattgcaaca aatggtgttg tccatgtcat tgaccgtgtg cttacacaaa ttggtacctc      720

aattcaagac ttcattgaag cagaagatga cctttcatct tttagagcag ctgccatcac      780

atcggacata ttggaggccc ttggaagaga cggtcacttc acactctttg ctcccaccaa      840

tgaggctttt gagaaacttc cacgaggtgt cctagaaagg atcatgggag acaaagtggc      900

ttccgaagct cttatgaagt accacatctt aaatactctc cagtgttctg agtctattat      960

gggaggagca gtctttgaga cgctggaagg aaatacaatt gagataggat gtgacggtga     1020

cagtataaca gtaaatggaa tcaaaatggt gaacaaaaag gatattgtga caaataatgg     1080

tgtgatccat ttgattgatc aggtcctaat tcctgattct gccaaacaag ttattgagct     1140

ggctggaaaa cagcaaacca ccttcacgga tcttgtggcc caattaggct tggcatctgc     1200

tctgaggcca gatggagaat acactttgct ggcacctgtg aataatgcat tttctgatga     1260

tactctcagc atggatcagc gcctccttaa attaattctg cagaatcaca tattgaaagt     1320

aaaagttggc cttaatgagc tttacaacgg gcaaatactg gaaaccatcg gaggcaaaca     1380

gctcagagtc ttcgtatatc gtacagctgt ctgcattgaa aattcatgca tggagaaagg     1440

gagtaagcaa gggagaaacg gtgcgattca catattccgc gagatcatca agccagcaga     1500

gaaatccctc catgaaaagt taaaacaaga taagcgcttt agcaccttcc tcagcctact     1560

tgaagctgca gacttgaaag agctcctgac acaacctgga gactggacat tatttgtgcc     1620

aaccaatgat gcttttaagg gaatgactag tgaagaaaaa gaaattctga tacgggacaa     1680

aaatgctctt caaaacatca ttctttatca cctgacacca ggagttttca ttggaaaagg     1740

atttgaacct ggtgttacta acattttaaa gaccacacaa ggaagcaaaa tctttctgaa     1800

agaagtaaat gatacacttc tggtgaatga attgaaatca aaagaatctg acatcatgac     1860

aacaaatggt gtaattcatg ttgtagataa actcctctat ccagcagaca cacctgttgg     1920

aaatgatcaa ctgctggaaa tacttaataa attaatcaaa tacatccaaa ttaagtttgt     1980

tcgtggtagc accttcaaag aaatccccgt gactgtctat ggtcctgaaa taaaatacac     2040

taggatttct actggaggtg gagaaacaga agaaactctg aagaaattgt tacaagaacc     2100

cgtgaggaag ttgcaagcca acaaaaaagt tcaaggatct agaagacgat taagggaagg     2160

tcgttctcag gggtctggct caggacacca tcatcaccat catcaccact aa             2212


<210>  16
<211>  788
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Arg Arg Thr Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ile Val Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile 
            20                  25                  30          


Leu Ala His Ser Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys 
        35                  40                  45              


Ala Leu Gln Gln Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys 
    50                  55                  60                  


Lys Asn Trp Tyr Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu 
65                  70                  75                  80  


Tyr Glu Cys Cys Pro Gly Tyr Met Glu Thr Arg Met Glu Thr Glu Gly 
                85                  90                  95      


Met Glu Thr Lys Gly Cys Pro Ala Val Leu Pro Ile Asp His Val Tyr 
            100                 105                 110         


Gly Thr Leu Gly Ile Val Gly Ala Thr Thr Thr Gln Arg Tyr Ser Asp 
        115                 120                 125             


Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly Lys Gly Ser Phe Thr Tyr 
    130                 135                 140                 


Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn Leu Asp Ser Asp Ile Arg 
145                 150                 155                 160 


Arg Gly Leu Glu Ser Asn Val Asn Val Glu Leu Leu Asn Ala Leu His 
                165                 170                 175     


Ser His Met Ile Asn Lys Arg Met Glu Thr Leu Thr Lys Asp Leu Lys 
            180                 185                 190         


Asn Gly Met Glu Thr Ile Ile Pro Ser Met Glu Thr Tyr Asn Asn Leu 
        195                 200                 205             


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
    210                 215                 220                 


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
225                 230                 235                 240 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
                245                 250                 255     


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
            260                 265                 270         


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
        275                 280                 285             


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
    290                 295                 300                 


Arg Ile Met Glu Thr Gly Asp Lys Val Ala Ser Glu Ala Leu Met Glu 
305                 310                 315                 320 


Thr Lys Tyr His Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met 
                325                 330                 335     


Glu Thr Gly Gly Ala Val Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu 
            340                 345                 350         


Ile Gly Cys Asp Gly Asp Ser Ile Thr Val Asn Gly Ile Lys Met Glu 
        355                 360                 365             


Thr Val Asn Lys Lys Asp Ile Val Thr Asn Asn Gly Val Ile His Leu 
    370                 375                 380                 


Ile Asp Gln Val Leu Ile Pro Asp Ser Ala Lys Gln Val Ile Glu Leu 
385                 390                 395                 400 


Ala Gly Lys Gln Gln Thr Thr Phe Thr Asp Leu Val Ala Gln Leu Gly 
                405                 410                 415     


Leu Ala Ser Ala Leu Arg Pro Asp Gly Glu Tyr Thr Leu Leu Ala Pro 
            420                 425                 430         


Val Asn Asn Ala Phe Ser Asp Asp Thr Leu Ser Met Asp Gln Arg Leu 
        435                 440                 445             


Leu Lys Leu Ile Leu Gln Asn His Ile Leu Lys Val Lys Val Gly Leu 
    450                 455                 460                 


Asn Glu Leu Tyr Asn Gly Gln Ile Leu Glu Thr Ile Gly Gly Lys Gln 
465                 470                 475                 480 


Leu Arg Val Phe Val Tyr Arg Thr Ala Val Cys Ile Glu Asn Ser Cys 
                485                 490                 495     


Met Glu Thr Glu Lys Gly Ser Lys Gln Gly Arg Asn Gly Ala Ile His 
            500                 505                 510         


Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu Lys Ser Leu His Glu Lys 
        515                 520                 525             


Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe Leu Ser Leu Leu Glu Ala 
    530                 535                 540                 


Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro Gly Asp Trp Thr Leu Phe 
545                 550                 555                 560 


Val Pro Thr Asn Asp Ala Phe Lys Gly Met Thr Ser Glu Glu Lys Glu 
                565                 570                 575     


Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln Asn Ile Ile Leu Tyr His 
            580                 585                 590         


Leu Thr Pro Gly Val Phe Ile Gly Lys Gly Phe Glu Pro Gly Val Thr 
        595                 600                 605             


Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys Ile Phe Leu Lys Glu Val 
    610                 615                 620                 


Asn Asp Thr Leu Leu Val Asn Glu Leu Lys Ser Lys Glu Ser Asp Ile 
625                 630                 635                 640 


Met Thr Thr Asn Gly Val Ile His Val Val Asp Lys Leu Leu Tyr Pro 
                645                 650                 655     


Ala Asp Thr Pro Val Gly Asn Asp Gln Leu Leu Glu Ile Leu Asn Lys 
            660                 665                 670         


Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val Arg Gly Ser Thr Phe Lys 
        675                 680                 685             


Glu Ile Pro Val Thr Val Tyr Gly Pro Glu Ile Lys Tyr Thr Arg Ile 
    690                 695                 700                 


Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu Leu Gln 
705                 710                 715                 720 


Glu Glu Val Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp Gly His 
                725                 730                 735     


Leu Phe Glu Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp Thr Pro 
            740                 745                 750         


Val Arg Lys Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg 
        755                 760                 765             


Leu Arg Glu Gly Arg Ser Gln Gly Ser Gly Ser Gly His His His His 
    770                 775                 780                 


His His His His 
785             


<210>  17
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Arg Arg Thr Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ile Val Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile 
            20                  25                  30          


Leu Ala His Ser Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys 
        35                  40                  45              


Ala Leu Gln Gln Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys 
    50                  55                  60                  


Lys Asn Trp Tyr Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu 
65                  70                  75                  80  


Tyr Glu Cys Cys Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys 
                85                  90                  95      


Pro Ala Val Leu Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val 
            100                 105                 110         


Gly Ala Thr Thr Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu 
        115                 120                 125             


Glu Ile Glu Gly Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu 
    130                 135                 140                 


Ala Trp Asp Asn Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn 
145                 150                 155                 160 


Val Asn Val Glu Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys 
                165                 170                 175     


Arg Met Leu Thr Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met 
            180                 185                 190         


Tyr Asn Asn Leu Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val 
        195                 200                 205             


Thr Val Asn Cys Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn 
    210                 215                 220                 


Gly Val Val His Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser 
225                 230                 235                 240 


Ile Gln Asp Phe Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala 
                245                 250                 255     


Ala Ala Ile Thr Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His 
            260                 265                 270         


Phe Thr Leu Phe Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg 
        275                 280                 285             


Gly Val Leu Glu Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu 
    290                 295                 300                 


Met Lys Tyr His Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met 
305                 310                 315                 320 


Gly Gly Ala Val Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly 
                325                 330                 335     


Cys Asp Gly Asp Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys 
            340                 345                 350         


Lys Asp Ile Val Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val 
        355                 360                 365             


Leu Ile Pro Asp Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln 
    370                 375                 380                 


Gln Thr Thr Phe Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala 
385                 390                 395                 400 


Leu Arg Pro Asp Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala 
                405                 410                 415     


Phe Ser Asp Asp Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile 
            420                 425                 430         


Leu Gln Asn His Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr 
        435                 440                 445             


Asn Gly Gln Ile Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe 
    450                 455                 460                 


Val Tyr Arg Thr Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly 
465                 470                 475                 480 


Ser Lys Gln Gly Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile 
                485                 490                 495     


Lys Pro Ala Glu Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg 
            500                 505                 510         


Phe Ser Thr Phe Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu 
        515                 520                 525             


Leu Thr Gln Pro Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala 
    530                 535                 540                 


Phe Lys Gly Met Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys 
545                 550                 555                 560 


Asn Ala Leu Gln Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe 
                565                 570                 575     


Ile Gly Lys Gly Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr 
            580                 585                 590         


Gln Gly Ser Lys Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val 
        595                 600                 605             


Asn Glu Leu Lys Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val 
    610                 615                 620                 


Ile His Val Val Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly 
625                 630                 635                 640 


Asn Asp Gln Leu Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln 
                645                 650                 655     


Ile Lys Phe Val Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val 
            660                 665                 670         


Tyr Gly Pro Glu Ile Lys Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu 
        675                 680                 685             


Thr Glu Glu Thr Leu Lys Lys Leu Leu Gln Glu Pro Val Arg Lys Leu 
    690                 695                 700                 


Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly 
705                 710                 715                 720 


Arg Ser Gln Gly Ser Gly Ser Gly His His His His His His His His 
                725                 730                 735     


