                         SEQUENCE LISTING

<110>  Laterza, Omar
       Tanen, Michael
       Wong, Oitak
 
<120>  ANTIBODIES THAT BIND TO HUMAN TAU AND ASSAY FOR QUANTIFYING HUMAN
        TAU USING THE ANTIBODIES

<130>  23733-US-PCT

<150>  61/937,898
<151>  2014-02-10

<160>  79    

<170>  PatentIn version 3.5

<210>  1
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMAN TAU 441 WITH HIS TAG AND TEV CLEAVAGE SITE

<400>  1

Met His His His His His His Asp Tyr Asp Ile Pro Thr Thr Glu Asn 
1               5                   10                  15      


Leu Tyr Phe Gln Gly Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met 
            20                  25                  30          


Glu Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly 
        35                  40                  45              


Gly Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu 
    50                  55                  60                  


Lys Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro 
65                  70                  75                  80  


Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val 
                85                  90                  95      


Thr Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala 
            100                 105                 110         


Gln Pro His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly 
        115                 120                 125             


Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr 
    130                 135                 140                 


Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp 
145                 150                 155                 160 


Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg 
                165                 170                 175     


Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile 
            180                 185                 190         


Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu 
        195                 200                 205             


Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro 
    210                 215                 220                 


Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro 
225                 230                 235                 240 


Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser 
                245                 250                 255     


Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro 
            260                 265                 270         


Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys 
        275                 280                 285             


His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp 
    290                 295                 300                 


Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His 
305                 310                 315                 320 


Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu 
                325                 330                 335     


Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys 
            340                 345                 350         


Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys 
        355                 360                 365             


Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val 
    370                 375                 380                 


Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg 
385                 390                 395                 400 


Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys 
                405                 410                 415     


Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val 
            420                 425                 430         


Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr 
        435                 440                 445             


Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    450                 455                 460         


<210>  2
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  3
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu Glu Ala Gly Ile Gly 
65                  70                  75                  80  


Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala 
                85                  90                  95      


Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys 
            100                 105                 110         


Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala 
        115                 120                 125             


Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala 
    130                 135                 140                 


Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro 
145                 150                 155                 160 


Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr 
                165                 170                 175     


Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg 
            180                 185                 190         


Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser 
        195                 200                 205             


Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu 
    210                 215                 220                 


Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln 
225                 230                 235                 240 


Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser 
                245                 250                 255     


Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro 
            260                 265                 270         


Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
        275                 280                 285             


Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
    290                 295                 300                 


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
305                 310                 315                 320 


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
                325                 330                 335     


Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn 
            340                 345                 350         


Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
        355                 360                 365             


Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser 
    370                 375                 380                 


Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala 
385                 390                 395                 400 


Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
                405                 410         


<210>  4
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr 
        275                 280                 285             


Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly 
    290                 295                 300                 


Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln 
305                 310                 315                 320 


Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly 
                325                 330                 335     


Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys 
            340                 345                 350         


Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val 
        355                 360                 365             


Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly 
    370                 375                 380                 


Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu 
385                 390                 395                 400 


Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
                405                 410 


<210>  5
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu Ala 
        35                  40                  45              


Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
    50                  55                  60                  


Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
65                  70                  75                  80  


Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
                85                  90                  95      


Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
            100                 105                 110         


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
        115                 120                 125             


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
    130                 135                 140                 


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
145                 150                 155                 160 


Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
                165                 170                 175     


Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
            180                 185                 190         


Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu 
        195                 200                 205             


Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu 
    210                 215                 220                 


Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
225                 230                 235                 240 


His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp 
                245                 250                 255     


Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His 
            260                 265                 270         


Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
        275                 280                 285             


Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His 
    290                 295                 300                 


Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
305                 310                 315                 320 


Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr 
                325                 330                 335     


Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn 
            340                 345                 350         


Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala 
        355                 360                 365             


Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    370                 375                 380             


<210>  6
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu Glu Ala Gly Ile Gly 
65                  70                  75                  80  


Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala 
                85                  90                  95      


Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys 
            100                 105                 110         


Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala 
        115                 120                 125             


Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala 
    130                 135                 140                 


Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro 
145                 150                 155                 160 


Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr 
                165                 170                 175     


Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg 
            180                 185                 190         


Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser 
        195                 200                 205             


Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu 
    210                 215                 220                 


Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln 
225                 230                 235                 240 


Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser 
                245                 250                 255     


Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro 
            260                 265                 270         


Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
        275                 280                 285             


Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro 
    290                 295                 300                 


Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu 
305                 310                 315                 320 


Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser 
                325                 330                 335     


Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser 
            340                 345                 350         


Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu 
        355                 360                 365             


Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    370                 375                 380     


<210>  7
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu Ala 
        35                  40                  45              


Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
    50                  55                  60                  


Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
65                  70                  75                  80  


Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
                85                  90                  95      


Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
            100                 105                 110         


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
        115                 120                 125             


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
    130                 135                 140                 


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
145                 150                 155                 160 


Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
                165                 170                 175     


Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
            180                 185                 190         


Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu 
        195                 200                 205             


Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val 
    210                 215                 220                 


Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
225                 230                 235                 240 


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
                245                 250                 255     


Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr 
            260                 265                 270         


His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr 
        275                 280                 285             


Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val 
    290                 295                 300                 


Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser 
305                 310                 315                 320 


Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu 
                325                 330                 335     


Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            340                 345                 350         


<210>  8
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMAN TAU 166 PEPTIDE FRAGMENT WITH HIS TAG AND TEV CLEAVAGE SITE

<400>  8

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Glu Glu Ala Gly Ile Gly Asp Thr 
            20                  25                  30          


Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met 
        35                  40                  45              


Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys 
    50                  55                  60                  


Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro 
65                  70                  75                  80  


Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr 
                85                  90                  95      


Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser 
            100                 105                 110         


Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly 
        115                 120                 125             


Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro 
    130                 135                 140                 


Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala 
145                 150                 155                 160 


Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn 
                165                 170                 175     


Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln 
            180                 185                 190 


<210>  9
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMAN TAU 166 PEPTIDE FRAGMENT

<400>  9

Glu Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala 
1               5                   10                  15      


Gly His Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr 
            20                  25                  30          


Gly Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile 
        35                  40                  45              


Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn 
    50                  55                  60                  


Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro 
65                  70                  75                  80  


Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser 
                85                  90                  95      


Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu 
            100                 105                 110         


Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr 
        115                 120                 125             


Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro 
    130                 135                 140                 


Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr 
145                 150                 155                 160 


Glu Asn Leu Lys His Gln 
                165     


<210>  10
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NUCLEIC ACID ENCODING H-TAU 166 PEPTIDE FRAGMENT

<400>  10
gaagaagcag gcattggaga cacccccagc ctggaagacg aagctgctgg tcacgtgacc       60

caagctcgca tggtcagtaa aagcaaagac gggactggaa gcgatgacaa aaaagccaag      120

ggggctgatg gtaaaacgaa gatcgccaca ccgcggggag cagcccctcc aggccagaag      180

ggccaggcca acgccaccag gattccagca aaaaccccgc ccgctccaaa gacaccaccc      240

agctctggtg aacctccaaa atcaggggat cgcagcggct acagcagccc cggctcccca      300

ggcactcccg gcagccgctc ccgcaccccg tcccttccaa ccccacccac ccgggagccc      360

aagaaggtgg cagtggtccg tactccaccc aagtcgccgt cttccgccaa gagccgcctg      420

cagacagccc ccgtgcccat gccagacctg aagaatgtca agtccaagat cggctccact      480

gagaacctga agcaccag                                                    498


<210>  11
<211>  5
<212>  PRT
<213>  MOUSE

<400>  11

Thr Arg Glu Pro Lys 
1               5   


<210>  12
<211>  6
<212>  PRT
<213>  MOUSE

<400>  12

Pro Lys Ser Gly Asp Arg 
1               5       


<210>  13
<211>  7
<212>  PRT
<213>  MOUSE

<400>  13

Pro Pro Thr Arg Glu Pro Lys 
1               5           


<210>  14
<211>  12
<212>  PRT
<213>  MOUSE

<400>  14

Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val 
1               5                   10          


<210>  15
<211>  11
<212>  PRT
<213>  MOUSE

<400>  15

Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val 
1               5                   10      


<210>  16
<211>  10
<212>  PRT
<213>  MOUSE

<400>  16

Gly Leu Met Val Gly Gly Val Val Ile Ala 
1               5                   10  


<210>  17
<211>  6
<212>  PRT
<213>  MOUSE

<400>  17

Glu Phe Arg His Asp Ser 
1               5       


<210>  18
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  19
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr 
            340                 345                 350         


Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala 
        355                 360                 365             


Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val 
625                 630                 635                 640 


Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser 
                645                 650                 655     


Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp 
            660                 665                 670         


Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
        675                 680                 685             


Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
    690                 695                 700                 


Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu 
705                 710                 715                 720 


Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
                725                 730                 735     


Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met 
            740                 745                 750         


Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
        755                 760                 765             


Gln Asn 
    770 


<210>  20
<211>  16
<212>  PRT
<213>  MOUSE

<400>  20

Arg Ser Ser Gln Asn Ile Ile His Ser Asn Gly Ser Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  21
<211>  7
<212>  PRT
<213>  MOUSE

<400>  21

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  MOUSE

<400>  22

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  23
<211>  19
<212>  PRT
<213>  MOUSE

<400>  23

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser 
            


<210>  24
<211>  112
<212>  PRT
<213>  MOUSE

<400>  24

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Ile His Ser 
            20                  25                  30          


Asn Gly Ser Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  25
<211>  336
<212>  DNA
<213>  MOUSE

<400>  25
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gaacattata catagtaatg gaagcaccta tttagaatgg      120

tacctgcaga aaccgggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggaatt tattactgct ttcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  26
<211>  10
<212>  PRT
<213>  MOUSE

<400>  26

Gly Phe Asn Ile Lys Asp Glu Tyr Met Asn 
1               5                   10  


<210>  27
<211>  17
<212>  PRT
<213>  MOUSE

<400>  27

Trp Ile Asp Pro Glu Asn Gly Asp Ala Ala Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  28
<211>  11
<212>  PRT
<213>  MOUSE

<400>  28

Phe Tyr Ser Asn Tyr Asp Gly Tyr Phe Asp Val 
1               5                   10      


<210>  29
<211>  19
<212>  PRT
<213>  MOUSE

<400>  29

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Ile Gly 
1               5                   10                  15      


Val Asn Ser 
            


<210>  30
<211>  120
<212>  PRT
<213>  MOUSE

<400>  30

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Glu 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Arg Pro Glu Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Ala Ala Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Phe Phe Tyr Ser Asn Tyr Asp Gly Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  31
<211>  360
<212>  DNA
<213>  MOUSE

<400>  31
gaggttcagc tgcagcagtc tggggctgag cttgtgaggc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt taacattaaa gacgagtata tgaactgggt gaagcagagg      120

cctgaacggg gcctggagtg gattggatgg attgatcctg aaaatggtga tgctgcatat      180

gcctcgaagt tccagggaaa ggccactatg actgcagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccgtct atttctgtac tttcttttac      300

agtaactacg acgggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      360


<210>  32
<211>  17
<212>  PRT
<213>  MOUSE

<400>  32

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  33
<211>  7
<212>  PRT
<213>  MOUSE

<400>  33

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  34
<211>  10
<212>  PRT
<213>  MOUSE

<400>  34

Gln Gln Tyr Tyr Ser Tyr Pro Leu Trp Thr 
1               5                   10  


<210>  35
<211>  20
<212>  PRT
<213>  MOUSE

<400>  35

Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly 
            20  


<210>  36
<211>  114
<212>  PRT
<213>  MOUSE

<400>  36

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Arg Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys 
        


<210>  37
<211>  342
<212>  DNA
<213>  MOUSE

<400>  37
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt caattggaga gaaggttact       60

atgagctgca agtccagtca gagcctttta tatagtaaca atcaaaagaa ctacttggcc      120

tggtaccagc ggaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcaccagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagttat      300

cctctgtgga cgttcggtgg aggcaccaag ctggaaatca aa                         342


<210>  38
<211>  12
<212>  PRT
<213>  MOUSE

<400>  38

Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Gly 
1               5                   10          


<210>  39
<211>  16
<212>  PRT
<213>  MOUSE

<400>  39

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Ala Val Leu Lys Ser 
1               5                   10                  15      


<210>  40
<211>  11
<212>  PRT
<213>  MOUSE

<400>  40

Ile Gly Ile Asp Gly Pro Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  41
<211>  19
<212>  PRT
<213>  MOUSE

<400>  41

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser 
            


<210>  42
<211>  121
<212>  PRT
<213>  MOUSE

<400>  42

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Ala Val 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Gly Ile Asp Gly Pro Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  43
<211>  363
<212>  DNA
<213>  MOUSE

<400>  43
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttctggta tgggtgtagg ctggattcgt      120

cagccttcag ggaagggtct ggaatggctg gcacacattt ggtgggatga tgataagtac      180

tataacgcag tcctgaagag ccggctcaca atctccaagg atacctccaa aaaccaggtt      240

ttcctcaaga tcgccagtgt ggacactgca gatactgcca catattactg tgctcgaata      300

gggattgatg gtccttatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  44

Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  45

Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  46

Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  47

Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  48

Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  49

Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  50

Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  51

Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  52

Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro 
1               5                   10                  15  


<210>  53
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  53

Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  54

Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  55

Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val 
1               5                   10                  15  


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  56

Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg 
1               5                   10                  15  


<210>  57
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  57

Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr 
1               5                   10                  15  


<210>  58
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  58

Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro 
1               5                   10                  15  


<210>  59
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  59

Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  60

Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
1               5                   10                  15  


<210>  61
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  61

Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  62

Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  63

Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys 
1               5                   10                  15  


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  64

Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  65

Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  66

Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly 
1               5                   10                  15  


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  67

Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  68

Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro 
1               5                   10                  15  


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  69

Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
1               5                   10                  15  


<210>  70
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  70

Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly 
1               5                   10                  15  


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  71

Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  72

Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser 
1               5                   10                  15  


<210>  73
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  73

Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser 
1               5                   10                  15  


<210>  74
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  74

Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro 
1               5                   10                  15  


<210>  75
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  75

Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly 
1               5                   10                  15  


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  76

Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
1               5                   10                  15  


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  77

Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro 
1               5                   10                  15  


<210>  78
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  78

Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE FRAGMENT OF HUMAN TAU

<400>  79

Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr 
1               5                   10                  15  


