                         SEQUENCE LISTING

<110>  The Hospital For Sick Children
       Vanderbilt University
 
<120>  COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING CLOSTRIDIUM 
       INFECTION

<130>  PAT 7848W-90

<150>  US 61/941,090
<151>  2014-02-18

<150>  US 62/076,689
<151>  2014-11-07

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  2372
<212>  PRT
<213>  Clostridium difficile

<400>  1

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             


Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 


Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu 
    770                 775                 780                 


Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         


Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Ile Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Thr Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Val Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Lys  His Val Ser 
    1115                 1120                 1125             


Leu Val  Glu Thr Glu Gly Val  Phe Thr Leu Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Val Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Val  Thr Asp Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ala  Pro Ser Ile Thr Tyr  Arg Glu Pro His Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp Asn Tyr Glu Gly  Glu Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser 
    1280                 1285                 1290             


Asn Thr  Arg Ser Phe Ile Val  Pro Ile Ile Thr Thr  Glu Tyr Ile 
    1295                 1300                 1305             


Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Gly Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Ser Glu  Ser Asp Val Trp Ile  Ile Asp Val Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Gly  Ile Leu Ser Thr Leu  Ser Ile Glu Glu Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asn  Ser His Glu Ile Asn  Phe Ser Gly Glu Val  Asn Gly Ser 
    1385                 1390                 1395             


Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Ile  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Leu Leu 
    1415                 1420                 1425             


Ile Ser  Gly Glu Leu Lys Ile  Leu Met Leu Asn Ser  Asn His Ile 
    1430                 1435                 1440             


Gln Gln  Lys Ile Asp Tyr Ile  Gly Phe Asn Ser Glu  Leu Gln Lys 
    1445                 1450                 1455             


Asn Ile  Pro Tyr Ser Phe Val  Asp Ser Glu Gly Lys  Glu Asn Gly 
    1460                 1465                 1470             


Phe Ile  Asn Gly Ser Thr Lys  Glu Gly Leu Phe Val  Ser Glu Leu 
    1475                 1480                 1485             


Pro Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asp Ser Lys 
    1490                 1495                 1500             


Pro Ser  Phe Gly Tyr Tyr Ser  Asn Asn Leu Lys Asp  Val Lys Val 
    1505                 1510                 1515             


Ile Thr  Lys Asp Asn Val Asn  Ile Leu Thr Gly Tyr  Tyr Leu Lys 
    1520                 1525                 1530             


Asp Asp  Ile Lys Ile Ser Leu  Ser Leu Thr Leu Gln  Asp Glu Lys 
    1535                 1540                 1545             


Thr Ile  Lys Leu Asn Ser Val  His Leu Asp Glu Ser  Gly Val Ala 
    1550                 1555                 1560             


Glu Ile  Leu Lys Phe Met Asn  Arg Lys Gly Asn Thr  Asn Thr Ser 
    1565                 1570                 1575             


Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile 
    1580                 1585                 1590             


Phe Val  Asn Phe Leu Gln Ser  Asn Ile Lys Phe Ile  Leu Asp Ala 
    1595                 1600                 1605             


Asn Phe  Ile Ile Ser Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe 
    1610                 1615                 1620             


Ile Cys  Asp Glu Asn Asp Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1625                 1630                 1635             


Asn Thr  Leu Glu Thr Asn Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln 
    1640                 1645                 1650             


Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp 
    1655                 1660                 1665             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly 
    1670                 1675                 1680             


Ile Asp  Ser Cys Val Asn Lys  Val Val Ile Ser Pro  Asn Ile Tyr 
    1685                 1690                 1695             


Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr Glu Thr  Asn Asn Thr 
    1700                 1705                 1710             


Tyr Pro  Glu Val Ile Val Leu  Asp Ala Asn Tyr Ile  Asn Glu Lys 
    1715                 1720                 1725             


Ile Asn  Val Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser 
    1730                 1735                 1740             


Asn Asp  Gly Asn Asp Phe Ile  Leu Met Ser Thr Ser  Glu Glu Asn 
    1745                 1750                 1755             


Lys Val  Ser Gln Val Lys Ile  Arg Phe Val Asn Val  Phe Lys Asp 
    1760                 1765                 1770             


Lys Thr  Leu Ala Asn Lys Leu  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1775                 1780                 1785             


Asp Val  Pro Val Ser Glu Ile  Ile Leu Ser Phe Thr  Pro Ser Tyr 
    1790                 1795                 1800             


Tyr Glu  Asp Gly Leu Ile Gly  Tyr Asp Leu Gly Leu  Val Ser Leu 
    1805                 1810                 1815             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser 
    1820                 1825                 1830             


Gly Leu  Ile Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1835                 1840                 1845             


Val Asn  Asn Leu Ile Thr Gly  Phe Val Thr Val Gly  Asp Asp Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Pro Ile Asn  Gly Gly Ala Ala Ser  Ile Gly Glu 
    1865                 1870                 1875             


Thr Ile  Ile Asp Asp Lys Asn  Tyr Tyr Phe Asn Gln  Ser Gly Val 
    1880                 1885                 1890             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asn Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1910                 1915                 1920             


Asp Phe  Thr Gly Lys Leu Ile  Ile Asp Glu Asn Ile  Tyr Tyr Phe 
    1925                 1930                 1935             


Asp Asp  Asn Tyr Arg Gly Ala  Val Glu Trp Lys Glu  Leu Asp Gly 
    1940                 1945                 1950             


Glu Met  His Tyr Phe Ser Pro  Glu Thr Gly Lys Ala  Phe Lys Gly 
    1955                 1960                 1965             


Leu Asn  Gln Ile Gly Asp Tyr  Lys Tyr Tyr Phe Asn  Ser Asp Gly 
    1970                 1975                 1980             


Val Met  Gln Lys Gly Phe Val  Ser Ile Asn Asp Asn  Lys His Tyr 
    1985                 1990                 1995             


Phe Asp  Asp Ser Gly Val Met  Lys Val Gly Tyr Thr  Glu Ile Asp 
    2000                 2005                 2010             


Gly Lys  His Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    2015                 2020                 2025             


Val Phe  Asn Thr Glu Asp Gly  Phe Lys Tyr Phe Ala  His His Asn 
    2030                 2035                 2040             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Glu Ile Ser  Tyr Ser Gly 
    2045                 2050                 2055             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    2060                 2065                 2070             


Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr Ile Gly  Leu Ser Leu 
    2090                 2095                 2100             


Ile Asn  Asp Gly Gln Tyr Tyr  Phe Asn Asp Asp Gly  Ile Met Gln 
    2105                 2110                 2115             


Val Gly  Phe Val Thr Ile Asn  Asp Lys Val Phe Tyr  Phe Ser Asp 
    2120                 2125                 2130             


Ser Gly  Ile Ile Glu Ser Gly  Val Gln Asn Ile Asp  Asp Asn Tyr 
    2135                 2140                 2145             


Phe Tyr  Ile Asp Asp Asn Gly  Ile Val Gln Ile Gly  Val Phe Asp 
    2150                 2155                 2160             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn 
    2165                 2170                 2175             


Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg 
    2180                 2185                 2190             


Val Gly  Glu Asp Val Tyr Tyr  Phe Gly Glu Thr Tyr  Thr Ile Glu 
    2195                 2200                 2205             


Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asn  Pro Glu Thr Lys Lys  Ala Cys Lys Gly Ile  Asn Leu Ile 
    2225                 2230                 2235             


Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Lys Gly Ile  Met Arg Thr 
    2240                 2245                 2250             


Gly Leu  Ile Ser Phe Glu Asn  Asn Asn Tyr Tyr Phe  Asn Glu Asn 
    2255                 2260                 2265             


Gly Glu  Met Gln Phe Gly Tyr  Ile Asn Ile Glu Asp  Lys Met Phe 
    2270                 2275                 2280             


Tyr Phe  Gly Glu Asp Gly Val  Met Gln Ile Gly Val  Phe Asn Thr 
    2285                 2290                 2295             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu 
    2300                 2305                 2310             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu 
    2315                 2320                 2325             


Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr 
    2330                 2335                 2340             


Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp 
    2345                 2350                 2355             


Thr Ala  Gln Leu Val Ile Ser  Glu His His His His  His His 
    2360                 2365                 2370         


<210>  2
<211>  2372
<212>  PRT
<213>  Clostridium difficile

<400>  2

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             


Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 


Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu 
    770                 775                 780                 


Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         


Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Ile Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Thr Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Lys Val Asn Asn Glu  Leu Val Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Lys  His Val Ser 
    1115                 1120                 1125             


Leu Val  Glu Thr Glu Gly Val  Phe Thr Leu Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Val Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Val  Thr Asp Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ala  Pro Ser Ile Thr Tyr  Arg Glu Pro His Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp Asn Tyr Glu Gly  Glu Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser 
    1280                 1285                 1290             


Asn Thr  Arg Ser Phe Ile Val  Pro Ile Ile Thr Thr  Glu Tyr Ile 
    1295                 1300                 1305             


Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Gly Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Ser Glu  Ser Asp Val Trp Ile  Ile Asp Val Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Gly  Ile Leu Ser Thr Leu  Ser Ile Glu Glu Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asn  Ser His Glu Ile Asn  Phe Ser Gly Glu Val  Asn Gly Ser 
    1385                 1390                 1395             


Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Ile  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Leu Leu 
    1415                 1420                 1425             


Ile Ser  Gly Glu Leu Lys Ile  Leu Met Leu Asn Ser  Asn His Ile 
    1430                 1435                 1440             


Gln Gln  Lys Ile Asp Tyr Ile  Gly Phe Asn Ser Glu  Leu Gln Lys 
    1445                 1450                 1455             


Asn Ile  Pro Tyr Ser Phe Val  Asp Ser Glu Gly Lys  Glu Asn Gly 
    1460                 1465                 1470             


Phe Ile  Asn Gly Ser Thr Lys  Glu Gly Leu Phe Val  Ser Glu Leu 
    1475                 1480                 1485             


Pro Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asp Ser Lys 
    1490                 1495                 1500             


Pro Ser  Phe Gly Tyr Tyr Ser  Asn Asn Leu Lys Asp  Val Lys Val 
    1505                 1510                 1515             


Ile Thr  Lys Asp Asn Val Asn  Ile Leu Thr Gly Tyr  Tyr Leu Lys 
    1520                 1525                 1530             


Asp Asp  Ile Lys Ile Ser Leu  Ser Leu Thr Leu Gln  Asp Glu Lys 
    1535                 1540                 1545             


Thr Ile  Lys Leu Asn Ser Val  His Leu Asp Glu Ser  Gly Val Ala 
    1550                 1555                 1560             


Glu Ile  Leu Lys Phe Met Asn  Arg Lys Gly Asn Thr  Asn Thr Ser 
    1565                 1570                 1575             


Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile 
    1580                 1585                 1590             


Phe Val  Asn Phe Leu Gln Ser  Asn Ile Lys Phe Ile  Leu Asp Ala 
    1595                 1600                 1605             


Asn Phe  Ile Ile Ser Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe 
    1610                 1615                 1620             


Ile Cys  Asp Glu Asn Asp Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1625                 1630                 1635             


Asn Thr  Leu Glu Thr Asn Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln 
    1640                 1645                 1650             


Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp 
    1655                 1660                 1665             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly 
    1670                 1675                 1680             


Ile Asp  Ser Cys Val Asn Lys  Val Val Ile Ser Pro  Asn Ile Tyr 
    1685                 1690                 1695             


Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr Glu Thr  Asn Asn Thr 
    1700                 1705                 1710             


Tyr Pro  Glu Val Ile Val Leu  Asp Ala Asn Tyr Ile  Asn Glu Lys 
    1715                 1720                 1725             


Ile Asn  Val Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser 
    1730                 1735                 1740             


Asn Asp  Gly Asn Asp Phe Ile  Leu Met Ser Thr Ser  Glu Glu Asn 
    1745                 1750                 1755             


Lys Val  Ser Gln Val Lys Ile  Arg Phe Val Asn Val  Phe Lys Asp 
    1760                 1765                 1770             


Lys Thr  Leu Ala Asn Lys Leu  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1775                 1780                 1785             


Asp Val  Pro Val Ser Glu Ile  Ile Leu Ser Phe Thr  Pro Ser Tyr 
    1790                 1795                 1800             


Tyr Glu  Asp Gly Leu Ile Gly  Tyr Asp Leu Gly Leu  Val Ser Leu 
    1805                 1810                 1815             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser 
    1820                 1825                 1830             


Gly Leu  Ile Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1835                 1840                 1845             


Val Asn  Asn Leu Ile Thr Gly  Phe Val Thr Val Gly  Asp Asp Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Pro Ile Asn  Gly Gly Ala Ala Ser  Ile Gly Glu 
    1865                 1870                 1875             


Thr Ile  Ile Asp Asp Lys Asn  Tyr Tyr Phe Asn Gln  Ser Gly Val 
    1880                 1885                 1890             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asn Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1910                 1915                 1920             


Asp Phe  Thr Gly Lys Leu Ile  Ile Asp Glu Asn Ile  Tyr Tyr Phe 
    1925                 1930                 1935             


Asp Asp  Asn Tyr Arg Gly Ala  Val Glu Trp Lys Glu  Leu Asp Gly 
    1940                 1945                 1950             


Glu Met  His Tyr Phe Ser Pro  Glu Thr Gly Lys Ala  Phe Lys Gly 
    1955                 1960                 1965             


Leu Asn  Gln Ile Gly Asp Tyr  Lys Tyr Tyr Phe Asn  Ser Asp Gly 
    1970                 1975                 1980             


Val Met  Gln Lys Gly Phe Val  Ser Ile Asn Asp Asn  Lys His Tyr 
    1985                 1990                 1995             


Phe Asp  Asp Ser Gly Val Met  Lys Val Gly Tyr Thr  Glu Ile Asp 
    2000                 2005                 2010             


Gly Lys  His Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    2015                 2020                 2025             


Val Phe  Asn Thr Glu Asp Gly  Phe Lys Tyr Phe Ala  His His Asn 
    2030                 2035                 2040             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Glu Ile Ser  Tyr Ser Gly 
    2045                 2050                 2055             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    2060                 2065                 2070             


Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr Ile Gly  Leu Ser Leu 
    2090                 2095                 2100             


Ile Asn  Asp Gly Gln Tyr Tyr  Phe Asn Asp Asp Gly  Ile Met Gln 
    2105                 2110                 2115             


Val Gly  Phe Val Thr Ile Asn  Asp Lys Val Phe Tyr  Phe Ser Asp 
    2120                 2125                 2130             


Ser Gly  Ile Ile Glu Ser Gly  Val Gln Asn Ile Asp  Asp Asn Tyr 
    2135                 2140                 2145             


Phe Tyr  Ile Asp Asp Asn Gly  Ile Val Gln Ile Gly  Val Phe Asp 
    2150                 2155                 2160             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn 
    2165                 2170                 2175             


Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg 
    2180                 2185                 2190             


Val Gly  Glu Asp Val Tyr Tyr  Phe Gly Glu Thr Tyr  Thr Ile Glu 
    2195                 2200                 2205             


Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asn  Pro Glu Thr Lys Lys  Ala Cys Lys Gly Ile  Asn Leu Ile 
    2225                 2230                 2235             


Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Lys Gly Ile  Met Arg Thr 
    2240                 2245                 2250             


Gly Leu  Ile Ser Phe Glu Asn  Asn Asn Tyr Tyr Phe  Asn Glu Asn 
    2255                 2260                 2265             


Gly Glu  Met Gln Phe Gly Tyr  Ile Asn Ile Glu Asp  Lys Met Phe 
    2270                 2275                 2280             


Tyr Phe  Gly Glu Asp Gly Val  Met Gln Ile Gly Val  Phe Asn Thr 
    2285                 2290                 2295             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu 
    2300                 2305                 2310             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu 
    2315                 2320                 2325             


Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr 
    2330                 2335                 2340             


Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp 
    2345                 2350                 2355             


Thr Ala  Gln Leu Val Ile Ser  Glu His His His His  His His 
    2360                 2365                 2370         


<210>  3
<211>  7119
<212>  DNA
<213>  Clostridium difficile

<400>  3
atgagcctgg tcaaccgtaa acaactggaa aaaatggcaa atgtccgctt tcgcacccaa       60

gaagatgaat atgtcgcaat cctggacgcg ctggaagaat accataacat gagcgaaaat      120

accgtggttg aaaagtacct gaagctgaag gatatcaact ccctgaccga tatttacatc      180

gacacgtata aaaagtcagg ccgtaacaag gcactgaaaa agttcaagga atatctggtg      240

accgaagttc tggaactgaa gaacaataac ctgacgccgg ttgaaaagaa cctgcacttc      300

gtctggattg gcggtcagat caacgatacc gctatcaact acatcaacca atggaaggat      360

gtgaactccg actacaacgt gaacgtgttt tatgattcaa acgcattcct gatcaacacc      420

ctgaaaaaga cggtcgtgga atctgctatc aatgataccc tggaaagttt tcgtgaaaat      480

ctgaacgatc cgcgcttcga ctacaacaag tttttccgta agcgcatgga aatcatctac      540

gataagcaga agaacttcat caactactac aaggcgcaac gtgaagaaaa tccggaactg      600

attatcgatg acatcgtgaa gacctacctg agcaacgaat actctaagga aatcgatgaa      660

ctgaacacct acattgaaga atccctgaac aaaatcacgc agaactcagg caacgatgtt      720

cgcaacttcg aagaattcaa gaacggtgaa agctttaacc tgtatgaaca agaactggtg      780

gaacgttgga acctggcggc cgcatcagat attctgcgca tctcggccct gaaagaaatt      840

ggcggtatgt atctggatgt tgacatgctg ccgggcattc agccggacct gtttgaatct      900

atcgaaaaac cgagctctgt caccgtggat ttctgggaaa tgacgaaact ggaagcgatt      960

atgaaataca aggaatatat cccggaatat accagtgaac attttgatat gctggacgaa     1020

gaagtgcaga gttccttcga atccgttctg gccagcaagt ccgacaaatc agaaattttt     1080

agcagcctgg gtgatatgga agcgtcgccg ctggaagtga agattgcctt caacagcaaa     1140

ggtattatca atcagggcct gatctctgtc aaagatagct actgctctaa tctgattgtg     1200

aagcaaatcg aaaaccgtta caagatcctg aacaacagcc tgaatccggc aatttctgaa     1260

gataacgact ttaataccac gaccaacacc ttcattgaca gcatcatggc ggaagccaac     1320

gcagataatg gccgttttat gatggaactg ggcaagtatc tgcgcgtggg ctttttcccg     1380

gatgttaaaa cgaccattaa tctgtctggt ccggaagcat acgctgcagc atatcaggat     1440

ctgctgatgt ttaaagaagg ttcaatgaac attcacctga tcgaagcaga tctgcgcaac     1500

ttcgaaatct cgaaaaccaa tatttcacag tcgacggaac aagaaatggc tagtctgtgg     1560

tcctttgatg acgctcgtgc gaaggcccag ttcgaagaat acaagcgcaa ctacttcgaa     1620

ggcagtctgg gtgaagatga caacctggac ttctcccaaa atattgttgt cgataaggaa     1680

tatctgctgg aaaaaatcag ctctctggcg cgtagttccg aacgcggcta cattcattat     1740

atcgttcagc tgcaaggtga taaaattagc tacgaagcag cttgcaacct gtttgcaaag     1800

accccgtatg actcagtgct gttccagaaa aatatcgaag attcggaaat cgcttactac     1860

tataacccgg gcgacggtga aatccaagaa atcgataagt acaagatccc gtcaatcatc     1920

tcggatcgtc cgaaaatcaa gctgaccttt attggccacg gtaaagatga attcaatacg     1980

gacatttttg cgggcttcga tgtggacagc ctgtctaccg aaattgaagc ggccatcgat     2040

ctggccaagg aagacattag cccgaaatct attgaaatca atctgctggg ctgtaacatg     2100

tttagttact ccatcaacgt ggaagaaacc tatccgggta aactgctgct gaaagttaag     2160

gacaaaattt cagaactgat gccgtcaatc tcgcaggata gtattatcgt ctccgccaac     2220

caatatgaag tgcgcattaa ttctgaaggc cgtcgcgaac tgctggatca ttcgggtgaa     2280

tggatcaaca aagaagaaag catcatcaag gatatctcat cgaaggaata catcagcttc     2340

aacccgaagg aaaacaagat caccgtgaag tccaagaacc tgccggaact gtcaacgctg     2400

ctgcaggaaa tccgtaataa cagtaacagc tctgatattg aactggaaga aaaagtgatg     2460

ctgaccgaat gcgaaattaa cgttatctcc aatattgata cgcagatcgt cgaagaacgc     2520

attgaagaag cgaaaaacct gaccagcgac tctattaact acatcaagga tgaattcaag     2580

ctgatcgaaa gtatttccga tgccctgtgt gacctgaaac agcaaaacga actggaagat     2640

tcacacttta tctcgttcga agatatttcg gaaaccgacg aaggctttag catccgcttc     2700

atcaacaagg aaacgggtga atcaatcttc gtggaaacgg aaaaaaccat cttctcggaa     2760

tatgcgaacc atattaccga agaaatcagc aagattaaag gcaccatttt tgacacggtt     2820

aatggtaaac tggtcaaaaa ggtgaacctg gatacgaccc acgaagtcaa caccctgaat     2880

gcagcgtttt tcattcagag cctgatcgaa tacaatagtt ccaaggaatc actgtcgaac     2940

ctgtcggttg caatgaaagt tcaggtctat gctcaactgt ttagcaccgg cctgaatacg     3000

attaccgatg cggccaaagt ggttgaactg gtgtctaccg cgctggatga aacgatcgac     3060

ctgctgccga ccctgagtga aggtctgccg attatcgcca cgattatcga tggcgtttcc     3120

ctgggtgcag ctattaaaga actgagtgaa acctccgatc cgctgctgcg tcaggaaatc     3180

gaagcaaaaa ttggcatcat ggctgttaac ctgacgaccg caacgaccgc tattatcacg     3240

tcatcgctgg gcatcgcatc aggtttttcg attctgctgg tgccgctggc aggtattagt     3300

gcaggtatcc cgtccctggt taataacgaa ctggtcctgc gcgacaaggc taccaaagtc     3360

gtggattatt ttaaacatgt tagcctggtc gaaaccgagg gtgtgttcac gctgctggat     3420

gacaaaatta tgatgccgca ggatgacctg gtcatctcgg aaatcgattt caacaacaac     3480

agcattgtgc tgggcaaatg tgaaatctgg cgtatggaag gcggtagcgg tcatacggtt     3540

accgatgaca tcgatcactt tttcagcgcg ccgtctatta cctaccgcga accgcacctg     3600

agcatctatg atgtgctgga agttcagaag gaagaactgg atctgtctaa agacctgatg     3660

gtcctgccga acgcgccgaa tcgtgtgttt gcctgggaaa cgggttggac cccgggtctg     3720

cgtagcctgg aaaatgatgg caccaaactg ctggatcgta ttcgcgacaa ctacgagggt     3780

gaattctact ggcgttattt tgccttcatc gcagatgctc tgattacgac cctgaaaccg     3840

cgttatgaag acaccaacat tcgcatcaat ctggatagca acacgcgttc ttttattgtg     3900

ccgattatca cgaccgaata tatccgcgaa aaactgagct actctttcta tggcagcggc     3960

ggtacctacg cactgagtct gtcccagtat aatatgggta ttaacatcga actgtcagaa     4020

tcggatgtgt ggattatcga tgttgacaat gttgtccgcg atgttaccat cgaaagcgac     4080

aaaattaaaa agggtgatct gatcgaaggc attctgagta cgctgtccat cgaagaaaac     4140

aagatcatcc tgaacagtca tgaaatcaat tttagcggcg aagttaacgg ctcaaatggt     4200

tttgtcagtc tgaccttctc cattctggaa ggtatcaacg ccattatcga agtggatctg     4260

ctgagcaagt cttataaact gctgatcagc ggcgaactga agattctgat gctgaattct     4320

aaccacatcc agcaaaagat cgattacatc ggtttcaaca gcgaactgca gaagaatatc     4380

ccgtactcat tcgttgattc ggaaggcaag gaaaatggtt tcatcaacgg ctctaccaaa     4440

gaaggcctgt ttgttagtga actgccggat gtggttctga ttagtaaggt ctatatggat     4500

gactcaaaac cgtcgtttgg ctactattcc aacaatctga aggacgtgaa ggttatcacc     4560

aaggataacg tgaacatcct gacgggttac tatctgaagg atgacattaa aatcagtctg     4620

tccctgaccc tgcaggacga aaagacgatt aaactgaatt cggtgcatct ggatgaaagc     4680

ggcgttgcag aaatcctgaa gtttatgaac cgtaaaggta atacgaacac ctcagattcg     4740

ctgatgagct tcctggaatc tatgaacatc aagtccatct tcgttaactt cctgcagtca     4800

aatatcaagt ttattctgga tgcgaacttc attatcagtg gtacgacctc catcggccag     4860

tttgaattca tttgcgatga aaatgacaac atccaaccgt actttattaa attcaacacg     4920

ctggaaacca attacacgct gtatgttggt aaccgccaga atatgattgt cgaaccgaat     4980

tatgacctgg atgactctgg cgatatcagc tctaccgtca ttaactttag tcaaaagtac     5040

ctgtatggta ttgattcgtg tgtgaacaaa gtcgtgatta gcccgaatat ctataccgat     5100

gaaattaaca tcacgccggt gtacgaaacc aacaatacgt atccggaagt cattgtgctg     5160

gacgcgaact acatcaacga aaagatcaac gttaacatca acgatctgtc tatccgttat     5220

gtctggagta acgatggcaa tgactttatc ctgatgagca cctctgaaga aaataaagtc     5280

agccaggtga aaattcgctt tgttaacgtc ttcaaggata aaacgctggc caacaagctg     5340

tcatttaatt tctcggataa acaagacgtg cctgttagtg aaattatcct gagctttacc     5400

ccgtcttact atgaagacgg cctgattggt tacgatctgg gtctggtttc cctgtacaac     5460

gaaaagttct acatcaacaa cttcggtatg atggtgtctg gcctgatcta catcaacgat     5520

agtctgtact acttcaaacc gccggtgaac aatctgatta ccggtttcgt cacggtgggc     5580

gatgacaagt actacttcaa cccgatcaac ggcggtgcgg ccagcatcgg cgaaaccatc     5640

atcgatgaca agaactacta cttcaaccag tctggtgtcc tgcaaaccgg cgtgttcagt     5700

acggaagacg gttttaaata tttcgcgccg gccaacaccc tggatgaaaa tctggaaggc     5760

gaagcgattg actttacggg caagctgatc atcgatgaaa acatctacta cttcgatgac     5820

aactaccgtg gcgcagtgga atggaaagaa ctggatggtg aaatgcatta ttttagcccg     5880

gaaaccggca aggctttcaa aggcctgaat cagattggtg actacaaata ctatttcaac     5940

agtgatggcg tcatgcaaaa gggtttcgtg tccatcaacg ataacaagca ttatttcgat     6000

gacagcggcg ttatgaaggt cggttacacc gaaattgatg gcaaacactt ttatttcgcg     6060

gaaaatggcg aaatgcagat cggtgttttt aacaccgaag atggttttaa atacttcgcc     6120

catcacaacg aagatctggg taatgaagaa ggcgaagaaa tcagttattc cggcattctg     6180

aacttcaaca acaagattta ttacttcgat gactcattca ccgccgttgt cggctggaag     6240

gatctggaag acggttcgaa atactatttc gatgaagaca cggcagaagc ttatatcggc     6300

ctgagtctga tcaacgatgg ccagtactac ttcaacgatg acggcatcat gcaagtgggt     6360

ttcgttacca tcaacgacaa ggtgttttat ttctcagatt cgggcattat cgaatctggt     6420

gttcagaaca tcgatgacaa ctacttctac atcgatgaca atggcatcgt ccaaattggt     6480

gtgtttgata ccagcgacgg ctacaagtac ttcgcgccgg ccaacacggt gaacgataat     6540

atttacggtc aggccgttga atattctggc ctggttcgtg tcggtgaaga tgtgtactat     6600

tttggcgaaa cgtacaccat cgaaaccggt tggatctacg acatggaaaa cgaaagcgat     6660

aaatattact tcaacccgga aacgaaaaag gcatgcaagg gtatcaatct gattgatgac     6720

atcaagtact atttcgatga aaaaggcatc atgcgcaccg gtctgatctc tttcgaaaac     6780

aacaactact acttcaacga aaacggtgaa atgcagtttg gttacatcaa catcgaagac     6840

aagatgttct atttcggcga agatggtgtt atgcagattg gcgtctttaa caccccggac     6900

ggttttaaat acttcgcgca tcaaaacacg ctggatgaaa acttcgaagg cgaaagtatc     6960

aactacaccg gttggctgga tctggacgaa aaacgctact attttaccga cgaatacatt     7020

gcagctacgg gcagcgtgat tatcgatggt gaagaatatt attttgaccc ggacaccgca     7080

caactggtta tttctgaaca tcatcatcat catcactaa                            7119


<210>  4
<211>  7119
<212>  DNA
<213>  Clostridium difficile

<400>  4
atgagcctgg tcaaccgtaa acaactggaa aaaatggcaa atgtccgctt tcgcacccaa       60

gaagatgaat atgtcgcaat cctggacgcg ctggaagaat accataacat gagcgaaaat      120

accgtggttg aaaagtacct gaagctgaag gatatcaact ccctgaccga tatttacatc      180

gacacgtata aaaagtcagg ccgtaacaag gcactgaaaa agttcaagga atatctggtg      240

accgaagttc tggaactgaa gaacaataac ctgacgccgg ttgaaaagaa cctgcacttc      300

gtctggattg gcggtcagat caacgatacc gctatcaact acatcaacca atggaaggat      360

gtgaactccg actacaacgt gaacgtgttt tatgattcaa acgcattcct gatcaacacc      420

ctgaaaaaga cggtcgtgga atctgctatc aatgataccc tggaaagttt tcgtgaaaat      480

ctgaacgatc cgcgcttcga ctacaacaag tttttccgta agcgcatgga aatcatctac      540

gataagcaga agaacttcat caactactac aaggcgcaac gtgaagaaaa tccggaactg      600

attatcgatg acatcgtgaa gacctacctg agcaacgaat actctaagga aatcgatgaa      660

ctgaacacct acattgaaga atccctgaac aaaatcacgc agaactcagg caacgatgtt      720

cgcaacttcg aagaattcaa gaacggtgaa agctttaacc tgtatgaaca agaactggtg      780

gaacgttgga acctggcggc cgcatcagat attctgcgca tctcggccct gaaagaaatt      840

ggcggtatgt atctggatgt tgacatgctg ccgggcattc agccggacct gtttgaatct      900

atcgaaaaac cgagctctgt caccgtggat ttctgggaaa tgacgaaact ggaagcgatt      960

atgaaataca aggaatatat cccggaatat accagtgaac attttgatat gctggacgaa     1020

gaagtgcaga gttccttcga atccgttctg gccagcaagt ccgacaaatc agaaattttt     1080

agcagcctgg gtgatatgga agcgtcgccg ctggaagtga agattgcctt caacagcaaa     1140

ggtattatca atcagggcct gatctctgtc aaagatagct actgctctaa tctgattgtg     1200

aagcaaatcg aaaaccgtta caagatcctg aacaacagcc tgaatccggc aatttctgaa     1260

gataacgact ttaataccac gaccaacacc ttcattgaca gcatcatggc ggaagccaac     1320

gcagataatg gccgttttat gatggaactg ggcaagtatc tgcgcgtggg ctttttcccg     1380

gatgttaaaa cgaccattaa tctgtctggt ccggaagcat acgctgcagc atatcaggat     1440

ctgctgatgt ttaaagaagg ttcaatgaac attcacctga tcgaagcaga tctgcgcaac     1500

ttcgaaatct cgaaaaccaa tatttcacag tcgacggaac aagaaatggc tagtctgtgg     1560

tcctttgatg acgctcgtgc gaaggcccag ttcgaagaat acaagcgcaa ctacttcgaa     1620

ggcagtctgg gtgaagatga caacctggac ttctcccaaa atattgttgt cgataaggaa     1680

tatctgctgg aaaaaatcag ctctctggcg cgtagttccg aacgcggcta cattcattat     1740

atcgttcagc tgcaaggtga taaaattagc tacgaagcag cttgcaacct gtttgcaaag     1800

accccgtatg actcagtgct gttccagaaa aatatcgaag attcggaaat cgcttactac     1860

tataacccgg gcgacggtga aatccaagaa atcgataagt acaagatccc gtcaatcatc     1920

tcggatcgtc cgaaaatcaa gctgaccttt attggccacg gtaaagatga attcaatacg     1980

gacatttttg cgggcttcga tgtggacagc ctgtctaccg aaattgaagc ggccatcgat     2040

ctggccaagg aagacattag cccgaaatct attgaaatca atctgctggg ctgtaacatg     2100

tttagttact ccatcaacgt ggaagaaacc tatccgggta aactgctgct gaaagttaag     2160

gacaaaattt cagaactgat gccgtcaatc tcgcaggata gtattatcgt ctccgccaac     2220

caatatgaag tgcgcattaa ttctgaaggc cgtcgcgaac tgctggatca ttcgggtgaa     2280

tggatcaaca aagaagaaag catcatcaag gatatctcat cgaaggaata catcagcttc     2340

aacccgaagg aaaacaagat caccgtgaag tccaagaacc tgccggaact gtcaacgctg     2400

ctgcaggaaa tccgtaataa cagtaacagc tctgatattg aactggaaga aaaagtgatg     2460

ctgaccgaat gcgaaattaa cgttatctcc aatattgata cgcagatcgt cgaagaacgc     2520

attgaagaag cgaaaaacct gaccagcgac tctattaact acatcaagga tgaattcaag     2580

ctgatcgaaa gtatttccga tgccctgtgt gacctgaaac agcaaaacga actggaagat     2640

tcacacttta tctcgttcga agatatttcg gaaaccgacg aaggctttag catccgcttc     2700

atcaacaagg aaacgggtga atcaatcttc gtggaaacgg aaaaaaccat cttctcggaa     2760

tatgcgaacc atattaccga agaaatcagc aagattaaag gcaccatttt tgacacggtt     2820

aatggtaaac tggtcaaaaa ggtgaacctg gatacgaccc acgaagtcaa caccctgaat     2880

gcagcgtttt tcattcagag cctgatcgaa tacaatagtt ccaaggaatc actgtcgaac     2940

ctgtcggttg caatgaaagt tcaggtctat gctcaactgt ttagcaccgg cctgaatacg     3000

attaccgatg cggccaaagt ggttgaactg gtgtctaccg cgctggatga aacgatcgac     3060

ctgctgccga ccctgagtga aggtctgccg attatcgcca cgattatcga tggcgtttcc     3120

ctgggtgcag ctattaaaga actgagtgaa acctccgatc cgctgctgcg tcaggaaatc     3180

gaagcaaaaa ttggcatcat ggctgttaac ctgacgaccg caacgaccgc tattatcacg     3240

tcatcgctgg gcatcgcatc aggtttttcg attctgctgg tgccgctggc aggtattagt     3300

gcaggtatcc cgtccaaggt taataacgaa ctggtcctgc gcgacaaggc taccaaagtc     3360

gtggattatt ttaaacatgt tagcctggtc gaaaccgagg gtgtgttcac gctgctggat     3420

gacaaaatta tgatgccgca ggatgacctg gtcatctcgg aaatcgattt caacaacaac     3480

agcattgtgc tgggcaaatg tgaaatctgg cgtatggaag gcggtagcgg tcatacggtt     3540

accgatgaca tcgatcactt tttcagcgcg ccgtctatta cctaccgcga accgcacctg     3600

agcatctatg atgtgctgga agttcagaag gaagaactgg atctgtctaa agacctgatg     3660

gtcctgccga acgcgccgaa tcgtgtgttt gcctgggaaa cgggttggac cccgggtctg     3720

cgtagcctgg aaaatgatgg caccaaactg ctggatcgta ttcgcgacaa ctacgagggt     3780

gaattctact ggcgttattt tgccttcatc gcagatgctc tgattacgac cctgaaaccg     3840

cgttatgaag acaccaacat tcgcatcaat ctggatagca acacgcgttc ttttattgtg     3900

ccgattatca cgaccgaata tatccgcgaa aaactgagct actctttcta tggcagcggc     3960

ggtacctacg cactgagtct gtcccagtat aatatgggta ttaacatcga actgtcagaa     4020

tcggatgtgt ggattatcga tgttgacaat gttgtccgcg atgttaccat cgaaagcgac     4080

aaaattaaaa agggtgatct gatcgaaggc attctgagta cgctgtccat cgaagaaaac     4140

aagatcatcc tgaacagtca tgaaatcaat tttagcggcg aagttaacgg ctcaaatggt     4200

tttgtcagtc tgaccttctc cattctggaa ggtatcaacg ccattatcga agtggatctg     4260

ctgagcaagt cttataaact gctgatcagc ggcgaactga agattctgat gctgaattct     4320

aaccacatcc agcaaaagat cgattacatc ggtttcaaca gcgaactgca gaagaatatc     4380

ccgtactcat tcgttgattc ggaaggcaag gaaaatggtt tcatcaacgg ctctaccaaa     4440

gaaggcctgt ttgttagtga actgccggat gtggttctga ttagtaaggt ctatatggat     4500

gactcaaaac cgtcgtttgg ctactattcc aacaatctga aggacgtgaa ggttatcacc     4560

aaggataacg tgaacatcct gacgggttac tatctgaagg atgacattaa aatcagtctg     4620

tccctgaccc tgcaggacga aaagacgatt aaactgaatt cggtgcatct ggatgaaagc     4680

ggcgttgcag aaatcctgaa gtttatgaac cgtaaaggta atacgaacac ctcagattcg     4740

ctgatgagct tcctggaatc tatgaacatc aagtccatct tcgttaactt cctgcagtca     4800

aatatcaagt ttattctgga tgcgaacttc attatcagtg gtacgacctc catcggccag     4860

tttgaattca tttgcgatga aaatgacaac atccaaccgt actttattaa attcaacacg     4920

ctggaaacca attacacgct gtatgttggt aaccgccaga atatgattgt cgaaccgaat     4980

tatgacctgg atgactctgg cgatatcagc tctaccgtca ttaactttag tcaaaagtac     5040

ctgtatggta ttgattcgtg tgtgaacaaa gtcgtgatta gcccgaatat ctataccgat     5100

gaaattaaca tcacgccggt gtacgaaacc aacaatacgt atccggaagt cattgtgctg     5160

gacgcgaact acatcaacga aaagatcaac gttaacatca acgatctgtc tatccgttat     5220

gtctggagta acgatggcaa tgactttatc ctgatgagca cctctgaaga aaataaagtc     5280

agccaggtga aaattcgctt tgttaacgtc ttcaaggata aaacgctggc caacaagctg     5340

tcatttaatt tctcggataa acaagacgtg cctgttagtg aaattatcct gagctttacc     5400

ccgtcttact atgaagacgg cctgattggt tacgatctgg gtctggtttc cctgtacaac     5460

gaaaagttct acatcaacaa cttcggtatg atggtgtctg gcctgatcta catcaacgat     5520

agtctgtact acttcaaacc gccggtgaac aatctgatta ccggtttcgt cacggtgggc     5580

gatgacaagt actacttcaa cccgatcaac ggcggtgcgg ccagcatcgg cgaaaccatc     5640

atcgatgaca agaactacta cttcaaccag tctggtgtcc tgcaaaccgg cgtgttcagt     5700

acggaagacg gttttaaata tttcgcgccg gccaacaccc tggatgaaaa tctggaaggc     5760

gaagcgattg actttacggg caagctgatc atcgatgaaa acatctacta cttcgatgac     5820

aactaccgtg gcgcagtgga atggaaagaa ctggatggtg aaatgcatta ttttagcccg     5880

gaaaccggca aggctttcaa aggcctgaat cagattggtg actacaaata ctatttcaac     5940

agtgatggcg tcatgcaaaa gggtttcgtg tccatcaacg ataacaagca ttatttcgat     6000

gacagcggcg ttatgaaggt cggttacacc gaaattgatg gcaaacactt ttatttcgcg     6060

gaaaatggcg aaatgcagat cggtgttttt aacaccgaag atggttttaa atacttcgcc     6120

catcacaacg aagatctggg taatgaagaa ggcgaagaaa tcagttattc cggcattctg     6180

aacttcaaca acaagattta ttacttcgat gactcattca ccgccgttgt cggctggaag     6240

gatctggaag acggttcgaa atactatttc gatgaagaca cggcagaagc ttatatcggc     6300

ctgagtctga tcaacgatgg ccagtactac ttcaacgatg acggcatcat gcaagtgggt     6360

ttcgttacca tcaacgacaa ggtgttttat ttctcagatt cgggcattat cgaatctggt     6420

gttcagaaca tcgatgacaa ctacttctac atcgatgaca atggcatcgt ccaaattggt     6480

gtgtttgata ccagcgacgg ctacaagtac ttcgcgccgg ccaacacggt gaacgataat     6540

atttacggtc aggccgttga atattctggc ctggttcgtg tcggtgaaga tgtgtactat     6600

tttggcgaaa cgtacaccat cgaaaccggt tggatctacg acatggaaaa cgaaagcgat     6660

aaatattact tcaacccgga aacgaaaaag gcatgcaagg gtatcaatct gattgatgac     6720

atcaagtact atttcgatga aaaaggcatc atgcgcaccg gtctgatctc tttcgaaaac     6780

aacaactact acttcaacga aaacggtgaa atgcagtttg gttacatcaa catcgaagac     6840

aagatgttct atttcggcga agatggtgtt atgcagattg gcgtctttaa caccccggac     6900

ggttttaaat acttcgcgca tcaaaacacg ctggatgaaa acttcgaagg cgaaagtatc     6960

aactacaccg gttggctgga tctggacgaa aaacgctact attttaccga cgaatacatt     7020

gcagctacgg gcagcgtgat tatcgatggt gaagaatatt attttgaccc ggacaccgca     7080

caactggtta tttctgaaca tcatcatcat catcactaa                            7119


<210>  5
<211>  16
<212>  PRT
<213>  Clostridium difficile

<400>  5

Ile Ile Ala Thr Ile Ile Asp Gly Val Ser Leu Gly Ala Ala Ile Lys 
1               5                   10                  15      


<210>  6
<211>  15
<212>  PRT
<213>  Clostridium difficile

<400>  6

Val Pro Leu Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn 
1               5                   10                  15  


<210>  7
<211>  16
<212>  PRT
<213>  Clostridium difficile

<400>  7

Ile Val Ser Thr Ile Leu Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys 
1               5                   10                  15      


<210>  8
<211>  15
<212>  PRT
<213>  Clostridium difficile

<400>  8

Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn 
1               5                   10                  15  


<210>  9
<211>  16
<212>  PRT
<213>  Corynebacterium diphtheriae

<400>  9

Asn Val Ala Gln Val Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys 
1               5                   10                  15      


<210>  10
<211>  15
<212>  PRT
<213>  Corynebacterium diphtheriae


<220>
<221>  MISC_FEATURE
<222>  (6)..(11)
<223>  Xaa is any amino acid

<400>  10

Ile Pro Leu Val Gly Xaa Xaa Xaa Xaa Xaa Xaa Glu Leu Val Asp 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Clostridium difficile

<400>  11

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu 
1               5                   10                  15  


<210>  12
<211>  20
<212>  PRT
<213>  Clostridium difficile

<400>  12

Val Pro Leu Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn 
1               5                   10                  15      


Glu Leu Val Leu 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  Clostridium difficile

<400>  13

Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn 
1               5                   10                  15      


Glu Leu Ile Leu 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  Clostridium difficile

<400>  14

Val Pro Leu Ala Gly Ile Ser Ala Gly Ile Pro Ser Lys Val Asn Asn 
1               5                   10                  15      


Glu Leu Val Leu 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Clostridium difficile

<400>  15

Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile Pro Ser Lys Val Asn Asn 
1               5                   10                  15      


Glu Leu Ile Leu 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  Clostridium difficile

<400>  16

Val Pro Leu Ala Gly Ile Ser Ala Gly Ile Pro Ser Lys Ser Ala Ser 
1               5                   10                  15      


Glu Leu Val Leu 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  Clostridium difficile

<400>  17

Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile Pro Ser Lys Ser Ala Ser 
1               5                   10                  15      


Glu Leu Ile Leu 
            20  


