               SEQUENCE LISTING

<110> ImmunePharma s.r.l.

<120> Biomarkers for lung tumor and related diagnostic methods and kit

<130> 15MR05E

<150> ITRM2014A000080
<151> 2014-02-24

<160> 29

<170> BiSSAP 1.2

<210> 1
<211> 377
<212> PRT
<213> Homo sapiens


<400> 1
Met Ala Glu Gly Asn His Arg Lys Lys Pro Leu Lys Val Leu Glu Ser 
1               5                   10                  15      
Leu Gly Lys Asp Phe Leu Thr Gly Val Leu Asp Asn Leu Val Glu Gln 
            20                  25                  30          
Asn Val Leu Asn Trp Lys Glu Glu Glu Lys Lys Lys Tyr Tyr Asp Ala 
        35                  40                  45              
Lys Thr Glu Asp Lys Val Arg Val Met Ala Asp Ser Met Gln Glu Lys 
    50                  55                  60                  
Gln Arg Met Ala Gly Gln Met Leu Leu Gln Thr Phe Phe Asn Ile Asp 
65                  70                  75                  80  
Gln Ile Ser Pro Asn Lys Lys Ala His Pro Asn Met Glu Ala Gly Pro 
                85                  90                  95      
Pro Glu Ser Gly Glu Ser Thr Asp Ala Leu Lys Leu Cys Pro His Glu 
            100                 105                 110         
Glu Phe Leu Arg Leu Cys Lys Glu Arg Ala Glu Glu Ile Tyr Pro Ile 
        115                 120                 125             
Lys Glu Arg Asn Asn Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr 
    130                 135                 140                 
Glu Phe Asp His Leu Pro Pro Arg Asn Gly Ala Asp Phe Asp Ile Thr 
145                 150                 155                 160 
Gly Met Lys Glu Leu Leu Glu Gly Leu Asp Tyr Ser Val Asp Val Glu 
                165                 170                 175     
Glu Asn Leu Thr Ala Arg Asp Met Glu Ser Ala Leu Arg Ala Phe Ala 
            180                 185                 190         
Thr Arg Pro Glu His Lys Ser Ser Asp Ser Thr Phe Leu Val Leu Met 
        195                 200                 205             
Ser His Gly Ile Leu Glu Gly Ile Cys Gly Thr Val His Asp Glu Lys 
    210                 215                 220                 
Lys Pro Asp Val Leu Leu Tyr Asp Thr Ile Phe Gln Ile Phe Asn Asn 
225                 230                 235                 240 
Arg Asn Cys Leu Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Val Gln 
                245                 250                 255     
Ala Cys Arg Gly Ala Asn Arg Gly Glu Leu Trp Val Arg Asp Ser Pro 
            260                 265                 270         
Ala Ser Leu Glu Val Ala Ser Ser Gln Ser Ser Glu Asn Leu Glu Glu 
        275                 280                 285             
Asp Ala Val Tyr Lys Thr His Val Glu Lys Asp Phe Ile Ala Phe Cys 
    290                 295                 300                 
Ser Ser Thr Pro His Asn Val Ser Trp Arg Asp Ser Thr Met Gly Ser 
305                 310                 315                 320 
Ile Phe Ile Thr Gln Leu Ile Thr Cys Phe Gln Lys Tyr Ser Trp Cys 
                325                 330                 335     
Cys His Leu Glu Glu Val Phe Arg Lys Val Gln Gln Ser Phe Glu Thr 
            340                 345                 350         
Pro Arg Ala Lys Ala Gln Met Pro Thr Ile Glu Arg Leu Ser Met Thr 
        355                 360                 365             
Arg Tyr Phe Tyr Leu Phe Pro Gly Asn 
    370                 375         

<210> 2
<211> 404
<212> PRT
<213> Homo sapiens


<400> 2
Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      
Met Gly Glu Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Thr 
            20                  25                  30          
Arg Val Leu Asn Lys Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala 
        35                  40                  45              
Thr Val Met Asp Lys Thr Arg Ala Leu Ile Asp Ser Val Ile Pro Lys 
    50                  55                  60                  
Gly Ala Gln Ala Cys Gln Ile Cys Ile Thr Tyr Ile Cys Glu Glu Asp 
65                  70                  75                  80  
Ser Tyr Leu Ala Gly Thr Leu Gly Leu Ser Ala Asp Gln Thr Ser Gly 
                85                  90                  95      
Asn Tyr Leu Asn Met Gln Asp Ser Gln Gly Val Leu Ser Ser Phe Pro 
            100                 105                 110         
Ala Pro Gln Ala Val Gln Asp Asn Pro Ala Met Pro Thr Ser Ser Gly 
        115                 120                 125             
Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu Glu Ala Gln Arg Ile 
    130                 135                 140                 
Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile Met Asp Lys Ser Ser 
145                 150                 155                 160 
Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Glu Glu Phe Asp Ser Ile 
                165                 170                 175     
Pro Arg Arg Thr Gly Ala Glu Val Asp Ile Thr Gly Met Thr Met Leu 
            180                 185                 190         
Leu Gln Asn Leu Gly Tyr Ser Val Asp Val Lys Lys Asn Leu Thr Ala 
        195                 200                 205             
Ser Asp Met Thr Thr Glu Leu Glu Ala Phe Ala His Arg Pro Glu His 
    210                 215                 220                 
Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser His Gly Ile Arg 
225                 230                 235                 240 
Glu Gly Ile Cys Gly Lys Lys His Ser Glu Gln Val Pro Asp Ile Leu 
                245                 250                 255     
Gln Leu Asn Ala Ile Phe Asn Met Leu Asn Thr Lys Asn Cys Pro Ser 
            260                 265                 270         
Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Asp 
        275                 280                 285             
Ser Pro Gly Val Val Trp Phe Lys Asp Ser Val Gly Val Ser Gly Asn 
    290                 295                 300                 
Leu Ser Leu Pro Thr Thr Glu Glu Phe Glu Asp Asp Ala Ile Lys Lys 
305                 310                 315                 320 
Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro Asp 
                325                 330                 335     
Asn Val Ser Trp Arg His Pro Thr Met Gly Ser Val Phe Ile Gly Arg 
            340                 345                 350         
Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp Val Glu Glu 
        355                 360                 365             
Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp Gly Arg Ala 
    370                 375                 380                 
Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr Arg Cys Phe Tyr Leu 
385                 390                 395                 400 
Phe Pro Gly His 
                

<210> 3
<211> 402
<212> PRT
<213> Mus musculus


<400> 3
Met Ala Asp Lys Ile Leu Arg Ala Lys Arg Lys Gln Phe Ile Asn Ser 
1               5                   10                  15      
Val Ser Ile Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Glu Lys 
            20                  25                  30          
Arg Val Leu Asn Gln Glu Glu Met Asp Lys Ile Lys Leu Ala Asn Ile 
        35                  40                  45              
Thr Ala Met Asp Lys Ala Arg Asp Leu Cys Asp His Val Ser Lys Lys 
    50                  55                  60                  
Gly Pro Gln Ala Ser Gln Ile Phe Ile Thr Tyr Ile Cys Asn Glu Asp 
65                  70                  75                  80  
Cys Tyr Leu Ala Gly Ile Leu Glu Leu Gln Ser Ala Pro Ser Ala Glu 
                85                  90                  95      
Thr Phe Val Ala Thr Glu Asp Ser Lys Gly Gly His Pro Ser Ser Ser 
            100                 105                 110         
Glu Thr Lys Glu Glu Gln Asn Lys Glu Asp Gly Thr Phe Pro Gly Leu 
        115                 120                 125             
Thr Gly Thr Leu Lys Phe Cys Pro Leu Glu Lys Ala Gln Lys Leu Trp 
    130                 135                 140                 
Lys Glu Asn Pro Ser Glu Ile Tyr Pro Ile Met Asn Thr Thr Thr Arg 
145                 150                 155                 160 
Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr Glu Phe Gln His Leu Ser 
                165                 170                 175     
Pro Arg Val Gly Ala Gln Val Asp Leu Arg Glu Met Lys Leu Leu Leu 
            180                 185                 190         
Glu Asp Leu Gly Tyr Thr Val Lys Val Lys Glu Asn Leu Thr Ala Leu 
        195                 200                 205             
Glu Met Val Lys Glu Val Lys Glu Phe Ala Ala Cys Pro Glu His Lys 
    210                 215                 220                 
Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser His Gly Ile Gln Glu 
225                 230                 235                 240 
Gly Ile Cys Gly Thr Thr Tyr Ser Asn Glu Val Ser Asp Ile Leu Lys 
                245                 250                 255     
Val Asp Thr Ile Phe Gln Met Met Asn Thr Leu Lys Cys Pro Ser Leu 
            260                 265                 270         
Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Glu Lys 
        275                 280                 285             
Gln Gly Val Val Leu Leu Lys Asp Ser Val Arg Asp Ser Glu Glu Asp 
    290                 295                 300                 
Phe Leu Thr Asp Ala Ile Phe Glu Asp Asp Gly Ile Lys Lys Ala His 
305                 310                 315                 320 
Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro Asp Asn Val 
                325                 330                 335     
Ser Trp Arg His Pro Val Arg Gly Ser Leu Phe Ile Glu Ser Leu Ile 
            340                 345                 350         
Lys His Met Lys Glu Tyr Ala Trp Ser Cys Asp Leu Glu Asp Ile Phe 
        355                 360                 365             
Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Glu Phe Arg Leu Gln Met 
    370                 375                 380                 
Pro Thr Ala Asp Arg Val Thr Leu Thr Lys Arg Phe Tyr Leu Phe Pro 
385                 390                 395                 400 
Gly His 
        

<210> 4
<211> 373
<212> PRT
<213> Mus musculus


<400> 4
Met Ala Glu Asn Lys His Pro Asp Lys Pro Leu Lys Val Leu Glu Gln 
1               5                   10                  15      
Leu Gly Lys Glu Val Leu Thr Glu Tyr Leu Glu Lys Leu Val Gln Ser 
            20                  25                  30          
Asn Val Leu Lys Leu Lys Glu Glu Asp Lys Gln Lys Phe Asn Asn Ala 
        35                  40                  45              
Glu Arg Ser Asp Lys Arg Trp Val Phe Val Asp Ala Met Lys Lys Lys 
    50                  55                  60                  
His Ser Lys Val Gly Glu Met Leu Leu Gln Thr Phe Phe Ser Val Asp 
65                  70                  75                  80  
Pro Gly Ser His His Gly Glu Ala Asn Leu Glu Met Glu Glu Pro Glu 
                85                  90                  95      
Glu Ser Leu Asn Thr Leu Lys Leu Cys Ser Pro Glu Glu Phe Thr Arg 
            100                 105                 110         
Leu Cys Arg Glu Lys Thr Gln Glu Ile Tyr Pro Ile Lys Glu Ala Asn 
        115                 120                 125             
Gly Arg Thr Arg Lys Ala Leu Ile Ile Cys Asn Thr Glu Phe Lys His 
    130                 135                 140                 
Leu Ser Leu Arg Tyr Gly Ala Asn Phe Asp Ile Ile Gly Met Lys Gly 
145                 150                 155                 160 
Leu Leu Glu Asp Leu Gly Tyr Asp Val Val Val Lys Glu Glu Leu Thr 
                165                 170                 175     
Ala Glu Gly Met Glu Ser Glu Met Lys Asp Phe Ala Ala Leu Ser Glu 
            180                 185                 190         
His Gln Thr Ser Asp Ser Thr Phe Leu Val Leu Met Ser His Gly Thr 
        195                 200                 205             
Leu His Gly Ile Cys Gly Thr Met His Ser Glu Lys Thr Pro Asp Val 
    210                 215                 220                 
Leu Gln Tyr Asp Thr Ile Tyr Gln Ile Phe Asn Asn Cys His Cys Pro 
225                 230                 235                 240 
Gly Leu Arg Asp Lys Pro Lys Val Ile Ile Val Gln Ala Cys Arg Gly 
                245                 250                 255     
Gly Asn Ser Gly Glu Met Trp Ile Arg Glu Ser Ser Lys Pro Gln Leu 
            260                 265                 270         
Cys Arg Gly Val Asp Leu Pro Arg Asn Met Glu Ala Asp Ala Val Lys 
        275                 280                 285             
Leu Ser His Val Glu Lys Asp Phe Ile Ala Phe Tyr Ser Thr Thr Pro 
    290                 295                 300                 
His His Leu Ser Tyr Arg Asp Lys Thr Gly Gly Ser Tyr Phe Ile Thr 
305                 310                 315                 320 
Arg Leu Ile Ser Cys Phe Arg Lys His Ala Cys Ser Cys His Leu Phe 
                325                 330                 335     
Asp Ile Phe Leu Lys Val Gln Gln Ser Phe Glu Lys Ala Ser Ile His 
            340                 345                 350         
Ser Gln Met Pro Thr Ile Asp Arg Ala Thr Leu Thr Arg Tyr Phe Tyr 
        355                 360                 365             
Leu Phe Pro Gly Asn 
    370             

<210> 5
<211> 354
<212> PRT
<213> Mus musculus


<400> 5
Met Glu Ser Glu Tyr Arg Glu Met Leu Leu Leu Thr Gly Leu Asp His 
1               5                   10                  15      
Ile Thr Glu Glu Glu Leu Lys Arg Phe Lys Tyr Phe Ala Leu Thr Glu 
            20                  25                  30          
Phe Gln Ile Ala Arg Ser Thr Leu Asp Val Ala Asp Arg Thr Glu Leu 
        35                  40                  45              
Ala Asp His Leu Ile Gln Ser Ala Gly Ala Ala Ser Ala Val Thr Lys 
    50                  55                  60                  
Ala Ile Asn Ile Phe Gln Lys Leu Asn Tyr Met His Ile Ala Asn Ala 
65                  70                  75                  80  
Leu Glu Glu Lys Lys Lys Glu Ala Glu Arg Lys Leu Met Thr Asn Thr 
                85                  90                  95      
Lys Lys Arg Gly Thr Gln Lys Val Glu Asn Arg Ser Gln Ala Glu Asn 
            100                 105                 110         
Cys Ser Ala Ala Ser Ala Thr Arg Ser Asp Asn Asp Phe Lys Glu Gln 
        115                 120                 125             
Ala Ala Thr Glu Val Cys Pro Gln Ala Lys Pro Gln Lys Lys Gln Met 
    130                 135                 140                 
Val Ala Glu Gln Glu Ala Ile Arg Glu Asp Leu Gln Lys Asp Pro Leu 
145                 150                 155                 160 
Val Val Thr Val Leu Lys Ala Ile Asn Pro Phe Glu Cys Glu Thr Gln 
                165                 170                 175     
Glu Gly Arg Gln Glu Ile Phe His Ala Thr Val Ala Thr Glu Thr Asp 
            180                 185                 190         
Phe Phe Phe Val Lys Val Leu Asn Ala Gln Phe Lys Asp Lys Phe Ile 
        195                 200                 205             
Pro Lys Arg Thr Ile Lys Ile Ser Asn Tyr Leu Trp His Ser Asn Phe 
    210                 215                 220                 
Met Glu Val Thr Ser Ser Ser Val Val Val Asp Val Glu Ser Asn His 
225                 230                 235                 240 
Glu Val Pro Asn Asn Val Val Lys Arg Ala Arg Glu Thr Pro Arg Ile 
                245                 250                 255     
Ser Lys Leu Lys Ile Gln Pro Cys Gly Thr Ile Val Asn Gly Leu Phe 
            260                 265                 270         
Lys Val Gln Lys Ile Thr Glu Glu Lys Asp Arg Val Leu Tyr Gly Ile 
        275                 280                 285             
His Asp Lys Thr Gly Thr Met Glu Val Leu Val Leu Gly Asn Pro Ser 
    290                 295                 300                 
Lys Thr Lys Cys Glu Glu Gly Asp Lys Ile Arg Leu Thr Phe Phe Glu 
305                 310                 315                 320 
Val Ser Lys Asn Gly Val Lys Ile Gln Leu Lys Ser Gly Pro Cys Ser 
                325                 330                 335     
Phe Phe Lys Val Ile Lys Ala Ala Lys Pro Lys Thr Asp Met Lys Ser 
            340                 345                 350         
Val Glu 
        

<210> 6
<211> 343
<212> PRT
<213> Homo sapiens


<400> 6
Met Glu Ser Lys Tyr Lys Glu Ile Leu Leu Leu Thr Gly Leu Asp Asn 
1               5                   10                  15      
Ile Thr Asp Glu Glu Leu Asp Arg Phe Lys Phe Phe Leu Ser Asp Glu 
            20                  25                  30          
Phe Asn Ile Ala Thr Gly Lys Leu His Thr Ala Asn Arg Ile Gln Val 
        35                  40                  45              
Ala Thr Leu Met Ile Gln Asn Ala Gly Ala Val Ser Ala Val Met Lys 
    50                  55                  60                  
Thr Ile Arg Ile Phe Gln Lys Leu Asn Tyr Met Leu Leu Ala Lys Arg 
65                  70                  75                  80  
Leu Gln Glu Glu Lys Glu Lys Val Asp Lys Gln Tyr Lys Ser Val Thr 
                85                  90                  95      
Lys Pro Lys Pro Leu Ser Gln Ala Glu Met Ser Pro Ala Ala Ser Ala 
            100                 105                 110         
Ala Ile Arg Asn Asp Val Ala Lys Gln Arg Ala Ala Pro Lys Val Ser 
        115                 120                 125             
Pro His Val Lys Pro Glu Gln Lys Gln Met Val Ala Gln Gln Glu Ser 
    130                 135                 140                 
Ile Arg Glu Gly Phe Gln Lys Arg Cys Leu Pro Val Met Val Leu Lys 
145                 150                 155                 160 
Ala Lys Lys Pro Phe Thr Phe Glu Thr Gln Glu Gly Lys Gln Glu Met 
                165                 170                 175     
Phe His Ala Thr Val Ala Thr Glu Lys Glu Phe Phe Phe Val Lys Val 
            180                 185                 190         
Phe Asn Thr Leu Leu Lys Asp Lys Phe Ile Pro Lys Arg Ile Ile Ile 
        195                 200                 205             
Ile Ala Arg Tyr Tyr Arg His Ser Gly Phe Leu Glu Val Asn Ser Ala 
    210                 215                 220                 
Ser Arg Val Leu Asp Ala Glu Ser Asp Gln Lys Val Asn Val Pro Leu 
225                 230                 235                 240 
Asn Ile Ile Arg Lys Ala Gly Glu Thr Pro Lys Ile Asn Thr Leu Gln 
                245                 250                 255     
Thr Gln Pro Leu Gly Thr Ile Val Asn Gly Leu Phe Val Val Gln Lys 
            260                 265                 270         
Val Thr Glu Lys Lys Lys Asn Ile Leu Phe Asp Leu Ser Asp Asn Thr 
        275                 280                 285             
Gly Lys Met Glu Val Leu Gly Val Arg Asn Glu Asp Thr Met Lys Cys 
    290                 295                 300                 
Lys Glu Gly Asp Lys Val Arg Leu Thr Phe Phe Thr Leu Ser Lys Asn 
305                 310                 315                 320 
Gly Glu Lys Leu Gln Leu Thr Ser Gly Val His Ser Thr Ile Lys Val 
                325                 330                 335     
Ile Lys Ala Lys Lys Lys Thr 
            340             

<210> 7
<211> 269
<212> PRT
<213> Mus musculus


<400> 7
Ala Lys Val Pro Asp Leu Phe Glu Asp Leu Lys Asn Cys Tyr Ser Glu 
1               5                   10                  15      
Asn Glu Asp Tyr Ser Ser Ala Ile Asp His Leu Ser Leu Asn Gln Lys 
            20                  25                  30          
Ser Phe Tyr Asp Ala Ser Tyr Gly Ser Leu His Glu Thr Cys Thr Asp 
        35                  40                  45              
Gln Phe Val Ser Leu Arg Thr Ser Glu Thr Ser Lys Met Ser Asn Phe 
    50                  55                  60                  
Thr Phe Lys Glu Ser Arg Val Thr Val Ser Ala Thr Ser Ser Asn Gly 
65                  70                  75                  80  
Lys Ile Leu Lys Lys Arg Arg Leu Ser Phe Ser Glu Thr Phe Thr Glu 
                85                  90                  95      
Asp Asp Leu Gln Ser Ile Thr His Asp Leu Glu Glu Thr Ile Gln Pro 
            100                 105                 110         
Arg Ser Ala Pro Tyr Thr Tyr Gln Ser Asp Leu Arg Tyr Lys Leu Met 
        115                 120                 125             
Lys Leu Val Arg Gln Lys Phe Val Met Asn Asp Ser Leu Asn Gln Thr 
    130                 135                 140                 
Ile Tyr Gln Asp Val Asp Lys His Tyr Leu Ser Thr Thr Trp Leu Asn 
145                 150                 155                 160 
Asp Leu Gln Gln Glu Val Lys Phe Asp Met Tyr Ala Tyr Ser Ser Gly 
                165                 170                 175     
Gly Asp Asp Ser Lys Tyr Pro Val Thr Leu Lys Ile Ser Asp Ser Gln 
            180                 185                 190         
Leu Phe Val Ser Ala Gln Gly Glu Asp Gln Pro Val Leu Leu Lys Glu 
        195                 200                 205             
Leu Pro Glu Thr Pro Lys Leu Ile Thr Gly Ser Glu Thr Asp Leu Ile 
    210                 215                 220                 
Phe Phe Trp Lys Ser Ile Asn Ser Lys Asn Tyr Phe Thr Ser Ala Ala 
225                 230                 235                 240 
Tyr Pro Glu Leu Phe Ile Ala Thr Lys Glu Gln Ser Arg Val His Leu 
                245                 250                 255     
Ala Arg Gly Leu Pro Ser Met Thr Asp Phe Gln Ile Ser 
            260                 265                 

<210> 8
<211> 271
<212> PRT
<213> Homo sapiens


<400> 8
Met Ala Lys Val Pro Asp Met Phe Glu Asp Leu Lys Asn Cys Tyr Ser 
1               5                   10                  15      
Glu Asn Glu Glu Asp Ser Ser Ser Ile Asp His Leu Ser Leu Asn Gln 
            20                  25                  30          
Lys Ser Phe Tyr His Val Ser Tyr Gly Pro Leu His Glu Gly Cys Met 
        35                  40                  45              
Asp Gln Ser Val Ser Leu Ser Ile Ser Glu Thr Ser Lys Thr Ser Lys 
    50                  55                  60                  
Leu Thr Phe Lys Glu Ser Met Val Val Val Ala Thr Asn Gly Lys Val 
65                  70                  75                  80  
Leu Lys Lys Arg Arg Leu Ser Leu Ser Gln Ser Ile Thr Asp Asp Asp 
                85                  90                  95      
Leu Glu Ala Ile Ala Asn Asp Ser Glu Glu Glu Ile Ile Lys Pro Arg 
            100                 105                 110         
Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg 
        115                 120                 125             
Ile Ile Lys Tyr Glu Phe Ile Leu Asn Asp Ala Leu Asn Gln Ser Ile 
    130                 135                 140                 
Ile Arg Ala Asn Asp Gln Tyr Leu Thr Ala Ala Ala Leu His Asn Leu 
145                 150                 155                 160 
Asp Glu Ala Val Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys Asp 
                165                 170                 175     
Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu Tyr 
            180                 185                 190         
Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met Pro 
        195                 200                 205             
Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe Phe 
    210                 215                 220                 
Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His Pro 
225                 230                 235                 240 
Asn Leu Phe Ile Ala Thr Lys Gln Asp Tyr Trp Val Cys Leu Ala Gly 
                245                 250                 255     
Gly Pro Pro Ser Ile Thr Asp Phe Gln Ile Leu Glu Asn Gln Ala 
            260                 265                 270     

<210> 9
<211> 269
<212> PRT
<213> Mus musculus


<400> 9
Met Ala Thr Val Pro Glu Leu Asn Cys Glu Met Pro Pro Phe Asp Ser 
1               5                   10                  15      
Asp Glu Asn Asp Leu Phe Phe Glu Val Asp Gly Pro Gln Lys Met Lys 
            20                  25                  30          
Gly Cys Phe Gln Thr Phe Asp Leu Gly Cys Pro Asp Glu Ser Ile Gln 
        35                  40                  45              
Leu Gln Ile Ser Gln Gln His Ile Asn Lys Ser Phe Arg Gln Ala Val 
    50                  55                  60                  
Ser Leu Ile Val Ala Val Glu Lys Leu Trp Gln Leu Pro Val Ser Phe 
65                  70                  75                  80  
Pro Trp Thr Phe Gln Asp Glu Asp Met Ser Thr Phe Phe Ser Phe Ile 
                85                  90                  95      
Phe Glu Glu Glu Pro Ile Leu Cys Asp Ser Trp Asp Asp Asp Asp Asn 
            100                 105                 110         
Leu Leu Val Cys Asp Val Pro Ile Arg Gln Leu His Tyr Arg Leu Arg 
        115                 120                 125             
Asp Glu Gln Gln Lys Ser Leu Val Leu Ser Asp Pro Tyr Glu Leu Lys 
    130                 135                 140                 
Ala Leu His Leu Asn Gly Gln Asn Ile Asn Gln Gln Val Ile Phe Ser 
145                 150                 155                 160 
Met Ser Phe Val Gln Gly Glu Pro Ser Asn Asp Lys Ile Pro Val Ala 
                165                 170                 175     
Leu Gly Leu Lys Gly Lys Asn Leu Tyr Leu Ser Cys Val Met Lys Asp 
            180                 185                 190         
Gly Thr Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Gln Tyr Pro 
        195                 200                 205             
Lys Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Val Lys 
    210                 215                 220                 
Ser Lys Val Glu Phe Glu Ser Ala Glu Phe Pro Asn Trp Tyr Ile Ser 
225                 230                 235                 240 
Thr Ser Gln Ala Glu His Lys Pro Val Phe Leu Gly Asn Asn Ser Gly 
                245                 250                 255     
Gln Asp Ile Ile Asp Phe Thr Met Glu Ser Val Ser Ser 
            260                 265                 

<210> 10
<211> 269
<212> PRT
<213> Homo sapiens


<400> 10
Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      
Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          
Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              
Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  
Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  
Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      
Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         
Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             
Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 
Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 
Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     
Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         
Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             
Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 
Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 
Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     
Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 

<210> 11
<211> 215
<212> PRT
<213> Mus musculus


<400> 11
Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      
Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          
Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              
Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  
Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  
Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      
Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         
Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             
Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 
Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 
Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     
Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Asp Asp Glu Glu 
            180                 185                 190         
Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu 
        195                 200                 205             
Glu Glu Asp Asp Asp Asp Glu 
    210                 215 

<210> 12
<211> 215
<212> PRT
<213> Homo sapiens


<400> 12
Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      
Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          
Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              
Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  
Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  
Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      
Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         
Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             
Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 
Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 
Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     
Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu 
            180                 185                 190         
Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu 
        195                 200                 205             
Glu Glu Asp Asp Asp Asp Asp 
    210                 215 

<210> 13
<211> 192
<212> PRT
<213> Mus musculus


<400> 13
Met Ala Ala Met Ser Glu Asp Ser Cys Val Asn Phe Lys Glu Met Met 
1               5                   10                  15      
Phe Ile Asp Asn Thr Leu Tyr Phe Ile Pro Glu Glu Asn Gly Asp Leu 
            20                  25                  30          
Glu Ser Asp Asn Phe Gly Arg Leu His Cys Thr Thr Ala Val Ile Arg 
        35                  40                  45              
Asn Ile Asn Asp Gln Val Leu Phe Val Asp Lys Arg Gln Pro Val Phe 
    50                  55                  60                  
Glu Asp Met Thr Asp Ile Asp Gln Ser Ala Ser Glu Pro Gln Thr Arg 
65                  70                  75                  80  
Leu Ile Ile Tyr Met Tyr Lys Asp Ser Glu Val Arg Gly Leu Ala Val 
                85                  90                  95      
Thr Leu Ser Val Lys Asp Ser Lys Met Ser Thr Leu Ser Cys Lys Asn 
            100                 105                 110         
Lys Ile Ile Ser Phe Glu Glu Met Asp Pro Pro Glu Asn Ile Asp Asp 
        115                 120                 125             
Ile Gln Ser Asp Leu Ile Phe Phe Gln Lys Arg Val Pro Gly His Asn 
    130                 135                 140                 
Lys Met Glu Phe Glu Ser Ser Leu Tyr Glu Gly His Phe Leu Ala Cys 
145                 150                 155                 160 
Gln Lys Glu Asp Asp Ala Phe Lys Leu Ile Leu Lys Lys Lys Asp Glu 
                165                 170                 175     
Asn Gly Asp Lys Ser Val Met Phe Thr Leu Thr Asn Leu His Gln Ser 
            180                 185                 190         



<210> 14
<211> 193
<212> PRT
<213> Homo sapiens


<400> 14
Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      
Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 
            20                  25                  30          
Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              
Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  
Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  
Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
                85                  90                  95      
Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         
Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             
Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 
His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 
Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     
Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         
Asp 
    

<210> 15
<211> 50
<212> PRT
<213> Homo sapiens

<220> 
<223> Synthetic peptide

<400> 15
Gly Ile Leu Glu Gly Ile Cys Gly Thr Val His Asp Glu Lys Lys Pro 
1               5                   10                  15      
Asp Val Leu Leu Tyr Asp Thr Ile Phe Gln Ile Phe Asn Asn Arg Asn 
            20                  25                  30          
Cys Leu Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Val Gln Ala Cys 
        35                  40                  45              
Arg Gly 
    50  

<210> 16
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 16
Ser Pro Asn Lys Lys Ala His Pro Asn Met Glu Ala Gly Pro Cys 
1               5                   10                  15  

<210> 17
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 17
Lys Lys Lys Tyr Tyr Asp Ala Lys Thr Glu Asp Lys Val Arg Cys 
1               5                   10                  15  

<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 18
Cys Ala Ser Ser Gln Ser Ser Glu Asn Leu Glu Glu Asp Ala Val 
1               5                   10                  15  

<210> 19
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 19
Met Ala Glu Gly Asn His Arg Lys Lys Pro Leu Lys Val Leu Cys 
1               5                   10                  15  

<210> 20
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 20
Cys Gln Ser Phe Glu Thr Pro Arg Ala Lys Ala Gln Met Pro Thr 
1               5                   10                  15  

<210> 21
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 21
Pro Glu Ser Gly Glu Ser Thr Asp Ala Leu Lys Leu Cys Pro Cys 
1               5                   10                  15  

<210> 22
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 22
Cys Thr Glu Phe Asp His Leu Pro Pro Arg Asn Gly Ala Asp Phe 
1               5                   10                  15  

<210> 23
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 23
Cys Gly Leu Asp Tyr Ser Val Asp Val Glu Glu Asn Leu Thr Ala 
1               5                   10                  15  

<210> 24
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 24
Cys Gly Thr Val His Asp Glu Lys Lys Pro Asp Val Leu Leu 
1               5                   10                  

<210> 25
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 25
Cys Gly Ala Asn Arg Gly Glu Leu Trp Val Arg Asp Ser Pro Ala 
1               5                   10                  15  

<210> 26
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 26
Cys Ser Ala Leu Arg Ala Phe Ala Thr Arg Pro Glu His Lys Ser 
1               5                   10                  15  

<210> 27
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 27
Cys Ile Tyr Pro Ile Lys Glu Arg Asn Asn Arg Thr Arg Leu Ala 
1               5                   10                  15  

<210> 28
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 28
Cys Ile Phe Asn Asn Arg Asn Cys Leu Ser Leu Lys Asp Lys Pro 
1               5                   10                  15  

<210> 29
<211> 1319
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1319
<223> /mol_type="mRNA"
      /organism="Homo sapiens"

<400> 29
auacauaguu uacuuucauu uuugacucug aggcucuuuc caacgcugua aaaaaggaca      60

gaggcuguuc ccuauggcag aaggcaacca cagaaaaaag ccacuuaagg uguuggaauc     120

ccugggcaaa gauuuccuca cugguguuuu ggauaacuug guggaacaaa auguacugaa     180

cuggaaggaa gaggaaaaaa agaaauauua cgaugcuaaa acugaagaca aaguucgggu     240

cauggcagac ucuaugcaag agaagcaacg uauggcagga caaaugcuuc uucaaaccuu     300

uuuuaacaua gaccaaauau cccccaauaa aaaagcucau ccgaauaugg aggcuggacc     360

accugaguca ggagaaucua cagaugcccu caagcuuugu ccucaugaag aauuccugag     420

acuauguaaa gaaagagcug aagagaucua uccaauaaag gagagaaaca accgcacacg     480

ccuggcucuc aucauaugca auacagaguu ugaccaucug ccuccgagga auggagcuga     540

cuuugacauc acagggauga aggagcuacu ugagggucug gacuauagug uagauguaga     600

agagaaucug acagccaggg auauggaguc agcgcugagg gcauuugcua ccagaccaga     660

gcacaagucc ucugacagca cauucuuggu acucaugucu cauggcaucc uggagggaau     720

cugcggaacu gugcaugaug agaaaaaacc agaugugcug cuuuaugaca ccaucuucca     780

gauauucaac aaccgcaacu gccucagucu gaaggacaaa cccaagguca ucauugucca     840

ggccugcaga ggugcaaacc guggggaacu gugggucaga gacucuccag cauccuugga     900

aguggccucu ucacagucau cugagaaccu agaggaagau gcuguuuaca agacccacgu     960

ggagaaggac uucauugcuu ucugcucuuc aacgccacac aacguguccu ggagagacag    1020

cacaaugggc ucuaucuuca ucacacaacu caucacaugc uuccagaaau auucuuggug    1080

cugccaccua gaggaaguau uucggaaggu acagcaauca uuugaaacuc caagggccaa    1140

agcucaaaug cccaccauag aacgacuguc caugacaaga uauuucuacc ucuuuccugg    1200

caauugaaaa uggaagccac aagcagccca gcccuccuua aucaacuuca aggagcaccu    1260

ucauuaguac agcuugcaua uuuaacauuu uguauuucaa uaaaagugaa gacaaacga     1319


