                         SEQUENCE LISTING

<110>  Wayne State University
       Wei, Wei-Zen
 
<120>  HER2 ANTIGENIC POLYPEPTIDE COMPOSITIONS, AND METHODS FOR THEIR 
       USE IN TREATMENT AND PREVENTION OF CARCINOMAS

<130>  0788.81

<160>  118   

<170>  PatentIn version 3.5

<210>  1
<211>  665
<212>  PRT
<213>  Felis catus

<400>  1

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu His Ala Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  


Ala His Asn Gln Val Lys Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Gly Asp Pro Leu Asp Ser Gly Thr Pro Ala Thr Gly Ala Ala Leu 
            100                 105                 110         


Gly Gly Leu Arg Glu Leu Lys Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys His Gln Asp Thr 
    130                 135                 140                 


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Met 
145                 150                 155                 160 


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys Gln Pro Cys Ser Pro Ala 
                165                 170                 175     


Cys Lys Asp Ser His Cys Trp Gly Ala Ser Ser Gly Asp Cys Gln Ser 
            180                 185                 190         


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             


Gln Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             


Cys Thr Leu Val Cys Pro Leu Asn Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Ala Arg Ala Val Thr Ser 
                325                 330                 335     


Ala Asn Ile Gln Glu Phe Val Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         


Ala Phe Leu Pro Glu Ser Phe Glu Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             


Pro Leu Gln Pro Glu Gln Leu Arg Val Phe Glu Ala Leu Glu Glu Ile 
    370                 375                 380                 


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asn Leu 
385                 390                 395                 400 


Ser Val Phe Gln Asn Leu Arg Val Ile Arg Gly Arg Val Leu His Asp 
                405                 410                 415     


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
            420                 425                 430         


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His Arg 
        435                 440                 445             


Asn Ser Arg Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
    450                 455                 460                 


Arg Asn Pro His Gln Ala Leu Leu His Ser Ala Asn Arg Pro Glu Asp 
465                 470                 475                 480 


Glu Cys Ala Gly Glu Gly Leu Ala Cys Tyr Pro Leu Cys Ala His Gly 
                485                 490                 495     


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
            500                 505                 510         


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
        515                 520                 525             


Pro Arg Glu Tyr Val Lys Asp Arg Phe Cys Leu Pro Cys His Pro Glu 
    530                 535                 540                 


Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Leu Gly Ser Glu Ala Asp 
545                 550                 555                 560 


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
                565                 570                 575     


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Phe Met Pro Ile Trp 
            580                 585                 590         


Lys Phe Ala Asp Glu Glu Gly Thr Cys Gln Pro Cys Pro Ile Asn Cys 
        595                 600                 605             


Thr His Ser Cys Ala Asp Leu Asp Glu Lys Gly Cys Pro Ala Glu Gln 
    610                 615                 620                 


Arg Ala Ser Pro Val Thr Ser Ile Ile Ala Ala Val Val Gly Ile Leu 
625                 630                 635                 640 


Leu Val Val Val Val Gly Leu Val Leu Gly Ile Leu Ile Lys Arg Arg 
                645                 650                 655     


Arg Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665 


<210>  2
<211>  665
<212>  PRT
<213>  Ursus americanus

<400>  2

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Ala Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Ala Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  


Ala His Ser Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Gly Glu Pro Pro Lys Gly Asp Thr Ser Val Ala Gly Ala Thr Pro 
            100                 105                 110         


Gly Gly Leu Arg Glu Leu Lys Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys His Gln Asp Thr 
    130                 135                 140                 


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
145                 150                 155                 160 


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys Gln Pro Cys Ser Pro Ala 
                165                 170                 175     


Cys Lys Asp Pro His Cys Trp Gly Ala Ser Ser Gly Asp Cys Gln Ser 
            180                 185                 190         


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             


Lys Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             


Cys Thr Leu Val Cys Pro Leu Asn Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 


Gly Thr Gln Arg Cys Glu Lys Cys Ser Arg Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Ala Arg Ala Val Thr Ser 
                325                 330                 335     


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         


Ala Phe Leu Pro Glu Ser Phe Glu Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             


Pro Leu Gln Pro Glu Gln Leu Arg Val Phe Glu Ala Leu Glu Glu Ile 
    370                 375                 380                 


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asn Leu 
385                 390                 395                 400 


Ser Val Phe Gln Asn Leu Arg Val Ile Arg Gly Arg Val Leu His Asp 
                405                 410                 415     


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
            420                 425                 430         


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His Arg 
        435                 440                 445             


Asn Ala Arg Leu Cys Phe Ile His Thr Val Pro Trp Glu Gln Leu Phe 
    450                 455                 460                 


Arg Asn Pro His Gln Ala Leu Leu His Ser Ala Asn Arg Pro Glu Ala 
465                 470                 475                 480 


Glu Cys Val Gly Glu Gly Leu Ala Cys Tyr Pro Leu Cys Ala His Gly 
                485                 490                 495     


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
            500                 505                 510         


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Glu Leu His Gly Leu 
        515                 520                 525             


Pro Arg Glu Tyr Val Lys Asp Arg Tyr Cys Leu Pro Cys His Pro Glu 
    530                 535                 540                 


Cys Arg Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Ser Glu Ala Asp 
545                 550                 555                 560 


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Ser Cys Val Ala 
                565                 570                 575     


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Phe Met Pro Ile Trp 
            580                 585                 590         


Lys Phe Ala Asp Glu Glu Gly Thr Cys Gln Pro Cys Pro Ile Asn Cys 
        595                 600                 605             


Thr His Ser Cys Gly Asp Leu Asp Glu Arg Gly Cys Pro Ala Glu Gln 
    610                 615                 620                 


Arg Ala Ser Pro Val Thr Ser Ile Ile Ala Ala Val Val Gly Ile Leu 
625                 630                 635                 640 


Leu Ala Val Val Met Gly Leu Val Leu Gly Ile Leu Ile Lys Arg Arg 
                645                 650                 655     


Arg Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665 


<210>  3
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  


Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
            100                 105                 110         


Gly Gly Leu Arg Glu Leu Lys Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
    130                 135                 140                 


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
145                 150                 155                 160 


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
                165                 170                 175     


Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
            180                 185                 190         


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             


Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             


Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
                325                 330                 335     


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         


Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             


Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile 
    370                 375                 380                 


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu 
385                 390                 395                 400 


Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn 
                405                 410                 415     


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
            420                 425                 430         


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His 
        435                 440                 445             


Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
    450                 455                 460                 


Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp 
465                 470                 475                 480 


Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly 
                485                 490                 495     


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
            500                 505                 510         


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
        515                 520                 525             


Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu 
    530                 535                 540                 


Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp 
545                 550                 555                 560 


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
                565                 570                 575     


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp 
            580                 585                 590         


Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys 
        595                 600                 605             


Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln 
    610                 615                 620                 


Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val Gly Ile Leu 
625                 630                 635                 640 


Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Lys Arg Arg 
                645                 650                 655     


Gln Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665 


<210>  4
<211>  666
<212>  PRT
<213>  Mus musculus

<400>  4

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Ala Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Met Leu Ile 
    50                  55                  60                  


Ala His Asn Arg Val Lys His Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Lys Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Arg Asp Pro Leu Asp Asn Val Thr Thr Ala Ala Pro Gly Arg Thr 
            100                 105                 110         


Pro Glu Gly Leu Arg Glu Leu Lys Leu Arg Ser Leu Thr Glu Ile Leu 
        115                 120                 125             


Lys Gly Gly Val Leu Ile Arg Gly Asn Pro Gln Leu Cys Tyr Gln Asp 
    130                 135                 140                 


Met Val Leu Trp Lys Asp Val Leu Arg Lys Asn Asn Gln Leu Ala Pro 
145                 150                 155                 160 


Val Asp Met Asp Thr Asn Arg Ser Arg Ala Cys Pro Pro Cys Ala Pro 
                165                 170                 175     


Thr Cys Lys Asp Asn His Cys Trp Gly Glu Ser Pro Glu Asp Cys Gln 
            180                 185                 190         


Ile Leu Thr Gly Thr Ile Cys Thr Ser Gly Cys Ala Arg Cys Lys Gly 
        195                 200                 205             


Arg Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr 
    210                 215                 220                 


Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser 
225                 230                 235                 240 


Gly Ile Cys Glu Leu His Cys Pro Ala Leu Ile Thr Tyr Asn Thr Asp 
                245                 250                 255     


Thr Phe Glu Ser Met Leu Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala 
            260                 265                 270         


Ser Cys Val Thr Thr Cys Pro Tyr Asn Tyr Leu Ser Thr Glu Val Gly 
        275                 280                 285             


Ser Cys Thr Leu Val Cys Pro Pro Asn Asn Gln Glu Val Thr Ala Glu 
    290                 295                 300                 


Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Gly Val 
305                 310                 315                 320 


Cys Tyr Gly Leu Gly Met Glu His Leu Arg Gly Ala Arg Ala Ile Thr 
                325                 330                 335     


Ser Asp Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser 
            340                 345                 350         


Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asn Pro Ser Ser Gly Val 
        355                 360                 365             


Ala Pro Leu Lys Pro Glu His Leu Gln Val Phe Glu Thr Leu Glu Glu 
    370                 375                 380                 


Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Glu Ser Phe Gln Asp 
385                 390                 395                 400 


Leu Ser Val Phe Gln Asn Leu Arg Val Ile Arg Gly Arg Ile Leu His 
                405                 410                 415     


Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile His Ser Leu 
            420                 425                 430         


Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His 
        435                 440                 445             


Arg Asn Thr His Leu Cys Phe Val Asn Thr Val Pro Trp Asp Gln Leu 
    450                 455                 460                 


Phe Arg Asn Pro His Gln Ala Leu Leu His Ser Gly Asn Arg Pro Glu 
465                 470                 475                 480 


Glu Ala Cys Gly Leu Glu Gly Leu Val Cys Asn Ser Leu Cys Ala Arg 
                485                 490                 495     


Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln 
            500                 505                 510         


Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Trp Lys Gly 
        515                 520                 525             


Leu Pro Arg Glu Tyr Val Arg Gly Lys His Cys Leu Pro Cys His Pro 
    530                 535                 540                 


Glu Cys Gln Pro Gln Asn Ser Ser Glu Thr Cys Tyr Gly Ser Glu Ala 
545                 550                 555                 560 


Asp Gln Cys Glu Ala Cys Ala His Tyr Lys Asp Ser Ser Ser Cys Val 
                565                 570                 575     


Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile 
            580                 585                 590         


Trp Lys Tyr Pro Asp Glu Glu Gly Ile Cys Gln Pro Cys Pro Ile Asn 
        595                 600                 605             


Cys Thr His Ser Cys Val Asp Leu Asp Glu Arg Gly Cys Pro Ala Glu 
    610                 615                 620                 


Gln Arg Ala Ser Pro Val Thr Phe Ile Ile Ala Thr Val Val Gly Val 
625                 630                 635                 640 


Leu Leu Phe Leu Ile Ile Val Val Val Ile Gly Ile Leu Ile Lys Arg 
                645                 650                 655     


Arg Arg Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665     


<210>  5
<211>  666
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Val Pro Ala Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Met Leu Ile 
    50                  55                  60                  


Ala His Asn Gln Val Lys Arg Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Lys Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Arg Asp Pro Gln Asp Asn Val Ala Ala Ser Thr Pro Gly Arg Thr 
            100                 105                 110         


Pro Glu Gly Leu Arg Glu Leu Lys Leu Arg Ser Leu Thr Glu Ile Leu 
        115                 120                 125             


Lys Gly Gly Val Leu Ile Arg Gly Asn Pro Gln Leu Cys Tyr Gln Asp 
    130                 135                 140                 


Met Val Leu Trp Lys Asp Val Phe Arg Lys Asn Asn Gln Leu Ala Pro 
145                 150                 155                 160 


Val Asp Ile Asp Thr Asn Arg Ser Arg Ala Cys Pro Pro Cys Ala Pro 
                165                 170                 175     


Ala Cys Lys Asp Asn His Cys Trp Gly Glu Ser Pro Glu Asp Cys Gln 
            180                 185                 190         


Ile Leu Thr Gly Thr Ile Cys Thr Ser Gly Cys Ala Arg Cys Lys Gly 
        195                 200                 205             


Arg Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr 
    210                 215                 220                 


Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser 
225                 230                 235                 240 


Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp 
                245                 250                 255     


Thr Phe Glu Ser Met His Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala 
            260                 265                 270         


Ser Cys Val Thr Thr Cys Pro Tyr Asn Tyr Leu Ser Thr Glu Val Gly 
        275                 280                 285             


Ser Cys Thr Leu Val Cys Pro Pro Asn Asn Gln Glu Val Thr Ala Glu 
    290                 295                 300                 


Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val 
305                 310                 315                 320 


Cys Tyr Gly Leu Gly Met Glu His Leu Arg Gly Ala Arg Ala Ile Thr 
                325                 330                 335     


Ser Asp Asn Val Gln Glu Phe Asp Gly Cys Lys Lys Ile Phe Gly Ser 
            340                 345                 350         


Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ser Ser Gly Ile 
        355                 360                 365             


Ala Pro Leu Arg Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu 
    370                 375                 380                 


Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Arg Asp 
385                 390                 395                 400 


Leu Ser Val Phe Gln Asn Leu Arg Ile Ile Arg Gly Arg Ile Leu His 
                405                 410                 415     


Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile His Ser Leu 
            420                 425                 430         


Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His 
        435                 440                 445             


Arg Asn Ala His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu 
    450                 455                 460                 


Phe Arg Asn Pro His Gln Ala Leu Leu His Ser Gly Asn Arg Pro Glu 
465                 470                 475                 480 


Glu Asp Cys Gly Leu Glu Gly Leu Val Cys Asn Ser Leu Cys Ala His 
                485                 490                 495     


Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser His 
            500                 505                 510         


Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Trp Lys Gly 
        515                 520                 525             


Leu Pro Arg Glu Tyr Val Ser Asp Lys Arg Cys Leu Pro Cys His Pro 
    530                 535                 540                 


Glu Cys Gln Pro Gln Asn Ser Ser Glu Thr Cys Phe Gly Ser Glu Ala 
545                 550                 555                 560 


Asp Gln Cys Ala Ala Cys Ala His Tyr Lys Asp Ser Ser Ser Cys Val 
                565                 570                 575     


Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile 
            580                 585                 590         


Trp Lys Tyr Pro Asp Glu Glu Gly Ile Cys Gln Pro Cys Pro Ile Asn 
        595                 600                 605             


Cys Thr His Ser Cys Val Asp Leu Asp Glu Arg Gly Cys Pro Ala Glu 
    610                 615                 620                 


Gln Arg Ala Ser Pro Val Thr Phe Ile Ile Ala Thr Val Val Gly Val 
625                 630                 635                 640 


Leu Leu Phe Leu Ile Leu Val Val Val Val Gly Ile Leu Ile Lys Arg 
                645                 650                 655     


Arg Arg Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665     


<210>  6
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric human-rat E2Neu (HER2)

<400>  6

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  


Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
            100                 105                 110         


Gly Gly Leu Arg Glu Leu Lys Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
    130                 135                 140                 


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
145                 150                 155                 160 


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
                165                 170                 175     


Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
            180                 185                 190         


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             


Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             


Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
                325                 330                 335     


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         


Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             


Glu Phe Ala Pro Leu Arg Pro Glu Gln Leu Gln Val Phe Glu Thr Leu 
    370                 375                 380                 


Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu 
385                 390                 395                 400 


Arg Asp Leu Ser Val Phe Gln Asn Leu Arg Ile Ile Arg Gly Arg Ile 
                405                 410                 415     


Leu His Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile His 
            420                 425                 430         


Ser Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu 
        435                 440                 445             


Ile His Arg Asn Ala His Leu Cys Phe Val His Thr Val Pro Trp Asp 
    450                 455                 460                 


Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Ser Gly Asn Arg 
465                 470                 475                 480 


Pro Glu Glu Asp Cys Gly Leu Glu Gly Leu Val Cys Asn Ser Leu Cys 
                485                 490                 495     


Ala His Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys 
            500                 505                 510         


Ser His Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Trp 
        515                 520                 525             


Lys Gly Leu Pro Arg Glu Tyr Val Ser Asp Lys Arg Cys Leu Pro Cys 
    530                 535                 540                 


His Pro Glu Cys Gln Pro Gln Asn Ser Ser Glu Thr Cys Phe Gly Ser 
545                 550                 555                 560 


Glu Ala Asp Gln Cys Ala Ala Cys Ala His Tyr Lys Asp Ser Ser Ser 
                565                 570                 575     


Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met 
            580                 585                 590         


Pro Ile Trp Lys Tyr Pro Asp Glu Glu Gly Ile Cys Gln Pro Cys Pro 
        595                 600                 605             


Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Glu Arg Gly Cys Pro 
    610                 615                 620                 


Ala Glu Gln Arg Ala Ser Pro Val Thr Phe Ile Ile Ala Thr Val Val 
625                 630                 635                 640 


Gly Val Leu Leu Phe Leu Ile Leu Val Val Val Val Gly Ile Leu Ile 
                645                 650                 655     


Lys Arg Arg Arg Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665             


<210>  7
<211>  687
<212>  PRT
<213>  Felis catus

<400>  7

Met Glu Leu Ala Ala Trp Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Ser Gly Ala Thr Gly Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu His Ala Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Lys Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asp Ser Gly Thr Pro 
        115                 120                 125             


Ala Thr Gly Ala Ala Leu Gly Gly Leu Arg Glu Leu Lys Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys His Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Met Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


Gln Pro Cys Ser Pro Ala Cys Lys Asp Ser His Cys Trp Gly Ala Ser 
        195                 200                 205             


Ser Gly Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Gln Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu Asn Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Ala Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Val Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Glu Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Arg Val Phe 
385                 390                 395                 400 


Glu Ala Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asn Leu Ser Val Phe Gln Asn Leu Arg Val Ile Arg 
            420                 425                 430         


Gly Arg Val Leu His Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His Arg Asn Ser Arg Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Ser 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Ala Gly Glu Gly Leu Ala Cys Tyr 
            500                 505                 510         


Pro Leu Cys Ala His Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Lys Asp Arg Phe Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Leu Gly Ser Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Phe Met Pro Ile Trp Lys Phe Ala Asp Glu Glu Gly Thr Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Ala Asp Leu Asp Glu Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Val Thr Ser Ile Ile Ala 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Val Gly Leu Val Leu Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Arg Gln Lys Ile Arg Lys Tyr Thr Met 
        675                 680                 685         


<210>  8
<211>  687
<212>  PRT
<213>  Ursus americanus

<400>  8

Met Glu Leu Ala Ala Trp Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Ser Gly Ala Ala Gly Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Ala Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Ala Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Ser Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Glu Pro Pro Lys Gly Asp Thr Ser 
        115                 120                 125             


Val Ala Gly Ala Thr Pro Gly Gly Leu Arg Glu Leu Lys Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys His Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


Gln Pro Cys Ser Pro Ala Cys Lys Asp Pro His Cys Trp Gly Ala Ser 
        195                 200                 205             


Ser Gly Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Lys Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu Asn Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Arg 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Ala Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Glu Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Arg Val Phe 
385                 390                 395                 400 


Glu Ala Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asn Leu Ser Val Phe Gln Asn Leu Arg Val Ile Arg 
            420                 425                 430         


Gly Arg Val Leu His Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His Arg Asn Ala Arg Leu Cys Phe Ile His Thr Val 
465                 470                 475                 480 


Pro Trp Glu Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Ser 
                485                 490                 495     


Ala Asn Arg Pro Glu Ala Glu Cys Val Gly Glu Gly Leu Ala Cys Tyr 
            500                 505                 510         


Pro Leu Cys Ala His Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Glu Leu His Gly Leu Pro Arg Glu Tyr Val Lys Asp Arg Tyr Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Arg Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Ser Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Ser Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Phe Met Pro Ile Trp Lys Phe Ala Asp Glu Glu Gly Thr Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Gly Asp Leu Asp Glu Arg 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Val Thr Ser Ile Ile Ala 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Ala Val Val Met Gly Leu Val Leu Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Arg Gln Lys Ile Arg Lys Tyr Thr Met 
        675                 680                 685         


<210>  9
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Lys Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 
        675                 680                 685         


<210>  10
<211>  688
<212>  PRT
<213>  Mus Musculus

<400>  10

Met Glu Leu Ala Ala Trp Cys Arg Trp Gly Phe Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ser Pro Gly Ala Ala Gly Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Ala Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Met Leu Ile Ala His Asn Arg Val Lys His Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Lys Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Arg Asp Pro Leu Asp Asn Val Thr Thr 
        115                 120                 125             


Ala Ala Pro Gly Arg Thr Pro Glu Gly Leu Arg Glu Leu Lys Leu Arg 
    130                 135                 140                 


Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Arg Gly Asn Pro 
145                 150                 155                 160 


Gln Leu Cys Tyr Gln Asp Met Val Leu Trp Lys Asp Val Leu Arg Lys 
                165                 170                 175     


Asn Asn Gln Leu Ala Pro Val Asp Met Asp Thr Asn Arg Ser Arg Ala 
            180                 185                 190         


Cys Pro Pro Cys Ala Pro Thr Cys Lys Asp Asn His Cys Trp Gly Glu 
        195                 200                 205             


Ser Pro Glu Asp Cys Gln Ile Leu Thr Gly Thr Ile Cys Thr Ser Gly 
    210                 215                 220                 


Cys Ala Arg Cys Lys Gly Arg Leu Pro Thr Asp Cys Cys His Glu Gln 
225                 230                 235                 240 


Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys 
                245                 250                 255     


Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu 
            260                 265                 270         


Ile Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Leu Asn Pro Glu Gly 
        275                 280                 285             


Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Thr Cys Pro Tyr Asn Tyr 
    290                 295                 300                 


Leu Ser Thr Glu Val Gly Ser Cys Thr Leu Val Cys Pro Pro Asn Asn 
305                 310                 315                 320 


Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser 
                325                 330                 335     


Lys Pro Cys Ala Gly Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg 
            340                 345                 350         


Gly Ala Arg Ala Ile Thr Ser Asp Asn Ile Gln Glu Phe Ala Gly Cys 
        355                 360                 365             


Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly 
    370                 375                 380                 


Asn Pro Ser Ser Gly Val Ala Pro Leu Lys Pro Glu His Leu Gln Val 
385                 390                 395                 400 


Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp 
                405                 410                 415     


Pro Glu Ser Phe Gln Asp Leu Ser Val Phe Gln Asn Leu Arg Val Ile 
            420                 425                 430         


Arg Gly Arg Ile Leu His Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly 
        435                 440                 445             


Leu Gly Ile His Ser Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser 
    450                 455                 460                 


Gly Leu Ala Leu Ile His Arg Asn Thr His Leu Cys Phe Val Asn Thr 
465                 470                 475                 480 


Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His 
                485                 490                 495     


Ser Gly Asn Arg Pro Glu Glu Ala Cys Gly Leu Glu Gly Leu Val Cys 
            500                 505                 510         


Asn Ser Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln 
        515                 520                 525             


Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu 
    530                 535                 540                 


Cys Arg Val Trp Lys Gly Leu Pro Arg Glu Tyr Val Arg Gly Lys His 
545                 550                 555                 560 


Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Ser Ser Glu Thr 
                565                 570                 575     


Cys Tyr Gly Ser Glu Ala Asp Gln Cys Glu Ala Cys Ala His Tyr Lys 
            580                 585                 590         


Asp Ser Ser Ser Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp 
        595                 600                 605             


Leu Ser Tyr Met Pro Ile Trp Lys Tyr Pro Asp Glu Glu Gly Ile Cys 
    610                 615                 620                 


Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Glu 
625                 630                 635                 640 


Arg Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Val Thr Phe Ile Ile 
                645                 650                 655     


Ala Thr Val Val Gly Val Leu Leu Phe Leu Ile Ile Val Val Val Ile 
            660                 665                 670         


Gly Ile Leu Ile Lys Arg Arg Arg Gln Lys Ile Arg Lys Tyr Thr Met 
        675                 680                 685             


<210>  11
<211>  691
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Met Ile Ile Met Glu Leu Ala Ala Trp Cys Arg Trp Gly Phe Leu Leu 
1               5                   10                  15      


Ala Leu Leu Pro Pro Gly Ile Ala Gly Thr Gln Val Cys Thr Gly Thr 
            20                  25                  30          


Asp Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met 
        35                  40                  45              


Leu Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu 
    50                  55                  60                  


Leu Thr Tyr Val Pro Ala Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile 
65                  70                  75                  80  


Gln Glu Val Gln Gly Tyr Met Leu Ile Ala His Asn Gln Val Lys Arg 
                85                  90                  95      


Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu 
            100                 105                 110         


Asp Lys Tyr Ala Leu Ala Val Leu Asp Asn Arg Asp Pro Gln Asp Asn 
        115                 120                 125             


Val Ala Ala Ser Thr Pro Gly Arg Thr Pro Glu Gly Leu Arg Glu Leu 
    130                 135                 140                 


Lys Leu Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Arg 
145                 150                 155                 160 


Gly Asn Pro Gln Leu Cys Tyr Gln Asp Met Val Leu Trp Lys Asp Val 
                165                 170                 175     


Phe Arg Lys Asn Asn Gln Leu Ala Pro Val Asp Ile Asp Thr Asn Arg 
            180                 185                 190         


Ser Arg Ala Cys Pro Pro Cys Ala Pro Ala Cys Lys Asp Asn His Cys 
        195                 200                 205             


Trp Gly Glu Ser Pro Glu Asp Cys Gln Ile Leu Thr Gly Thr Ile Cys 
    210                 215                 220                 


Thr Ser Gly Cys Ala Arg Cys Lys Gly Arg Leu Pro Thr Asp Cys Cys 
225                 230                 235                 240 


His Glu Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys 
                245                 250                 255     


Leu Ala Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys 
            260                 265                 270         


Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met His Asn 
        275                 280                 285             


Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Thr Cys Pro 
    290                 295                 300                 


Tyr Asn Tyr Leu Ser Thr Glu Val Gly Ser Cys Thr Leu Val Cys Pro 
305                 310                 315                 320 


Pro Asn Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu 
                325                 330                 335     


Lys Cys Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu 
            340                 345                 350         


His Leu Arg Gly Ala Arg Ala Ile Thr Ser Asp Asn Val Gln Glu Phe 
        355                 360                 365             


Asp Gly Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser 
    370                 375                 380                 


Phe Asp Gly Asp Pro Ser Ser Gly Ile Ala Pro Leu Arg Pro Glu Gln 
385                 390                 395                 400 


Leu Gln Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile 
                405                 410                 415     


Ser Ala Trp Pro Asp Ser Leu Arg Asp Leu Ser Val Phe Gln Asn Leu 
            420                 425                 430         


Arg Ile Ile Arg Gly Arg Ile Leu His Asp Gly Ala Tyr Ser Leu Thr 
        435                 440                 445             


Leu Gln Gly Leu Gly Ile His Ser Leu Gly Leu Arg Ser Leu Arg Glu 
    450                 455                 460                 


Leu Gly Ser Gly Leu Ala Leu Ile His Arg Asn Ala His Leu Cys Phe 
465                 470                 475                 480 


Val His Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala 
                485                 490                 495     


Leu Leu His Ser Gly Asn Arg Pro Glu Glu Asp Cys Gly Leu Glu Gly 
            500                 505                 510         


Leu Val Cys Asn Ser Leu Cys Ala His Gly His Cys Trp Gly Pro Gly 
        515                 520                 525             


Pro Thr Gln Cys Val Asn Cys Ser His Phe Leu Arg Gly Gln Glu Cys 
    530                 535                 540                 


Val Glu Glu Cys Arg Val Trp Lys Gly Leu Pro Arg Glu Tyr Val Ser 
545                 550                 555                 560 


Asp Lys Arg Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Ser 
                565                 570                 575     


Ser Glu Thr Cys Phe Gly Ser Glu Ala Asp Gln Cys Ala Ala Cys Ala 
            580                 585                 590         


His Tyr Lys Asp Ser Ser Ser Cys Val Ala Arg Cys Pro Ser Gly Val 
        595                 600                 605             


Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys Tyr Pro Asp Glu Glu 
    610                 615                 620                 


Gly Ile Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp 
625                 630                 635                 640 


Leu Asp Glu Arg Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Val Thr 
                645                 650                 655     


Phe Ile Ile Ala Thr Val Val Gly Val Leu Leu Phe Leu Ile Leu Val 
            660                 665                 670         


Val Val Val Gly Ile Leu Ile Lys Arg Arg Arg Gln Lys Ile Arg Lys 
        675                 680                 685             


Tyr Thr Met 
    690     


<210>  12
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric human-rat E2Neu (HER2)

<400>  12

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Lys Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Glu Phe Ala Pro Leu Arg Pro Glu Gln Leu 
385                 390                 395                 400 


Gln Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser 
                405                 410                 415     


Ala Trp Pro Asp Ser Leu Arg Asp Leu Ser Val Phe Gln Asn Leu Arg 
            420                 425                 430         


Ile Ile Arg Gly Arg Ile Leu His Asp Gly Ala Tyr Ser Leu Thr Leu 
        435                 440                 445             


Gln Gly Leu Gly Ile His Ser Leu Gly Leu Arg Ser Leu Arg Glu Leu 
    450                 455                 460                 


Gly Ser Gly Leu Ala Leu Ile His Arg Asn Ala His Leu Cys Phe Val 
465                 470                 475                 480 


His Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu 
                485                 490                 495     


Leu His Ser Gly Asn Arg Pro Glu Glu Asp Cys Gly Leu Glu Gly Leu 
            500                 505                 510         


Val Cys Asn Ser Leu Cys Ala His Gly His Cys Trp Gly Pro Gly Pro 
        515                 520                 525             


Thr Gln Cys Val Asn Cys Ser His Phe Leu Arg Gly Gln Glu Cys Val 
    530                 535                 540                 


Glu Glu Cys Arg Val Trp Lys Gly Leu Pro Arg Glu Tyr Val Ser Asp 
545                 550                 555                 560 


Lys Arg Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Ser Ser 
                565                 570                 575     


Glu Thr Cys Phe Gly Ser Glu Ala Asp Gln Cys Ala Ala Cys Ala His 
            580                 585                 590         


Tyr Lys Asp Ser Ser Ser Cys Val Ala Arg Cys Pro Ser Gly Val Lys 
        595                 600                 605             


Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys Tyr Pro Asp Glu Glu Gly 
    610                 615                 620                 


Ile Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu 
625                 630                 635                 640 


Asp Glu Arg Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Val Thr Phe 
                645                 650                 655     


Ile Ile Ala Thr Val Val Gly Val Leu Leu Phe Leu Ile Leu Val Val 
            660                 665                 670         


Val Val Gly Ile Leu Ile Lys Arg Arg Arg Gln Lys Ile Arg Lys Tyr 
        675                 680                 685             


Thr Met 
    690 


<210>  13
<211>  1995
<212>  DNA
<213>  Felis catus

<400>  13
acccaagtgt gcaccggcac agacatgaag ctgcggctcc cagccagtcc cgagacccac       60

ctggacatgc tccgccacct ctaccagggc tgtcaagtgg tacagggcaa cctggagctc      120

acctacctgc atgccaatgc cagcctctcc ttcctgcagg atatccagga ggtgcaaggc      180

tatgtgctca ttgcccacaa ccaagtgaaa caggtcccac tgcagaggct acgaatcgtg      240

cgaggcaccc agctctttga ggacaactac gccctggccg tgctggacaa cggagaccca      300

ctggacagtg gcacccctgc tacaggggct gccctaggag ggctgcggga gctgaagctc      360

cgaagcctca cagagatcct gaagggaggg gtcctcattc agcggaaccc gcagctctgc      420

caccaggaca cgattctgtg gaaggacatc ttccacaaga acaaccagct ggccctcatg      480

ctgatagaca ccaaccgctc tcgggcctgc caaccctgtt ctccagcttg taaagactcc      540

cactgctggg gagcaagttc cggggactgt cagagcttga ctcgaactgt ctgtgctggc      600

ggctgtgccc gctgcaaggg cccgcagccc accgactgct gccacgagca atgtgctgct      660

ggctgcacgg gccccaagca ttctgactgc ctggcctgcc tccacttcaa ccacagtggc      720

atctgtgagc tgcactgccc agccctggtc acctacaaca cggacacctt cgaatccatg      780

cccaaccctg agggccgtta taccttcggt gccagctgtg tgactgcctg tccctacaac      840

tacctgtcta cggacgtggg atcctgcacc ctggtctgtc ccctgaacaa ccaagaggtg      900

acagctgagg atggaacaca gcggtgtgag aaatgcagca agccctgtgc ccgagtgtgc      960

tacggcctag gcatggagca cctgcgggag gcgagggcag tcaccagtgc caacatccaa     1020

gaatttgtcg gctgcaagaa gatctttggg agcctggcgt ttctgccaga gagctttgag     1080

ggggacccag cctccaacac tgcccccctg cagcctgagc agctcagagt gtttgaggct     1140

ctggaggaga ttacaggtta cctgtacatc tcagcgtggc cagacagctt gcctaacctc     1200

agtgtcttcc agaacctcag agtgatccgg ggccgagttc tgcatgacgg tgcttactcg     1260

ctgacccttc aagggctggg catcagctgg ctggggctgc gctcgctgcg ggagctgggc     1320

agtgggctgg ccctcatcca ccgcaactcc cgcctctgct tcgtacacac ggtgccctgg     1380

gaccagctct tccggaaccc ccaccaggcc ctgctccaca gcgccaaccg gccagaggac     1440

gagtgcgcgg gtgagggcct ggcctgctat ccgctgtgtg cccacgggca ctgctggggt     1500

ccgggaccca cccagtgtgt caactgcagc cagttccttc ggggccagga gtgcgtggag     1560

gaatgccgag tattgcaggg gcttccccgg gagtatgtga aggataggtt ctgtctgcca     1620

tgccacccgg agtgtcagcc ccagaatggc tcagtgacct gcttgggctc ggaagctgac     1680

cagtgtgtgg cctgtgccca ctacaaggac cctcctttct gtgtggctcg ctgccccagt     1740

ggggtgaaac ctgacctctc cttcatgccc atctggaagt tcgcagatga ggagggcacg     1800

tgccagccat gccccatcaa ctgcacccac tcctgtgcgg acctggacga gaagggctgc     1860

cccgccgagc agagagccag ccctgtgacg tccatcattg ctgctgtggt gggcattctg     1920

ctggtcgtgg ttgtggggct ggtccttggc atcctaatca agcgaaggcg gcagaagatc     1980

cggaagtaca cgatg                                                      1995


<210>  14
<211>  1995
<212>  DNA
<213>  Ursus americanus

<400>  14
acccaagtgt gcaccggcac agacatgaag ctgcggctcc ctgccagtcc cgagacccac       60

ctggatatgc tccgccacct ctaccaggcc tgtcaagtgg tacagggtaa cctggagctc      120

acctacctgc ccgccaatgc cagcctgtcc ttcctgcagg atatccagga ggtacagggc      180

tatgtgctca ttgctcacag ccaagtgaga caggtcccgc tgcagaggct ccgaatcgtg      240

cgaggcaccc agctctttga ggacaactac gccctggccg tgctggacaa tggagagccg      300

cccaaggggg acacctctgt ggcaggggct accccaggag ggctgcggga gctgaagctt      360

cgaagcctca cagagatcct gaagggaggg gtcttgattc agcggaaccc acagctctgc      420

caccaggaca cgattttgtg gaaggacatc ttccacaaga acaaccagct ggccctcacg      480

ctgatagaca ccaaccgctc tcgggcctgc caaccctgtt ctccagcctg taaagacccc      540

cactgctggg gagcaagttc cggggactgt cagagcttga cacgaaccgt ctgtgccggc      600

ggctgtgccc gctgcaaggg cccaaaaccc actgactgct gccatgagca gtgcgcggct      660

ggctgcacgg gccccaagca ctcggactgc ctggcctgcc ttcacttcaa ccacagtggc      720

atctgtgagc tgcactgccc agccctggtc acctacaaca cggacacgtt cgaatccatg      780

cccaaccctg agggccgata caccttcggt gccagctgtg tgaccgcctg tccctacaac      840

tacctgtcca cggacgtggg atcctgcacc ctggtctgtc ccctgaacaa ccaagaggtg      900

acggctgagg atggcaccca gcggtgtgag aaatgcagca gaccctgtgc ccgagtgtgc      960

tatggtctgg gcatggagca cctgcgggag gcgagggcgg tcaccagcgc caacatccaa     1020

gagttcgccg gctgcaagaa gatctttggg agcctggcgt ttctgccaga gagcttcgag     1080

ggagacccag cctccaacac tgcccccctg cagcctgaac agctcagagt gttcgaggcc     1140

ctggaggaga tcacaggtta cctgtatatc tcagcgtggc cggacagctt gcctaacctc     1200

agtgtcttcc agaacctgcg agtaatccgg ggacgagttc tgcatgatgg cgcctactcg     1260

ctgaccctgc aagggctggg catcagctgg ctggggctgc gctcgctgcg ggaactgggc     1320

agcgggctgg ccctcatcca ccgcaacgcc cgcctctgct tcatccacac ggtgccctgg     1380

gagcagctct tccggaaccc ccaccaagcc ctgctgcaca gtgccaaccg gccggaggcc     1440

gagtgcgtgg gcgagggcct ggcctgctac ccgctgtgcg cccatgggca ctgctggggt     1500

ccggggccca cccagtgcgt caactgcagc caattccttc ggggccagga gtgcgtggag     1560

gaatgccgag aactgcacgg gctaccccgg gaatatgtga aggacagata ctgtctgcca     1620

tgccaccccg agtgtcggcc ccagaatggc tcagtgacct gctttgggtc ggaggctgac     1680

cagtgtgtgg cctgcgccca ctacaaggac cctccctcct gcgtggctcg ctgccccagt     1740

ggtgtgaaac ccgacctctc tttcatgccc atttggaagt ttgcagatga ggagggcaca     1800

tgccagccgt gccccatcaa ctgcacccac tcctgtgggg acctggacga gaggggctgc     1860

cccgccgaac agagagccag ccctgtgaca tccatcattg ccgctgtggt gggcattctg     1920

ctggccgtgg tcatggggct ggtcctcggc atcctgatca agcgaaggcg acagaagatc     1980

cggaagtaca cgatg                                                      1995


<210>  15
<211>  1998
<212>  DNA
<213>  Homo sapiens

<400>  15
acccaagtgt gcaccggcac agacatgaag ctgcggctcc ctgccagtcc cgagacccac       60

ctggacatgc tccgccacct ctaccagggc tgccaggtgg tgcagggaaa cctggaactc      120

acctacctgc ccaccaatgc cagcctgtcc ttcctgcagg atatccagga ggtgcagggc      180

tacgtgctca tcgctcacaa ccaagtgagg caggtcccac tgcagaggct gcggattgtg      240

cgaggcaccc agctctttga ggacaactat gccctggccg tgctagacaa tggagacccg      300

ctgaacaata ccacccctgt cacaggggcc tccccaggag gcctgcggga gctgaagctt      360

cgaagcctca cagagatctt gaaaggaggg gtcttgatcc agcggaaccc ccagctctgc      420

taccaggaca cgattttgtg gaaggacatc ttccacaaga acaaccagct ggctctcaca      480

ctgatagaca ccaaccgctc tcgggcctgc cacccctgtt ctccgatgtg taagggctcc      540

cgctgctggg gagagagttc tgaggattgt cagagcctga cgcgcactgt ctgtgccggt      600

ggctgtgccc gctgcaaggg gccactgccc actgactgct gccatgagca gtgtgctgcc      660

ggctgcacgg gccccaagca ctctgactgc ctggcctgcc tccacttcaa ccacagtggc      720

atctgtgagc tgcactgccc agccctggtc acctacaaca cagacacgtt tgagtccatg      780

cccaatcccg agggccggta tacattcggc gccagctgtg tgactgcctg tccctacaac      840

tacctttcta cggacgtggg atcctgcacc ctcgtctgcc ccctgcacaa ccaagaggtg      900

acagcagagg atggaacaca gcggtgtgag aagtgcagca agccctgtgc ccgagtgtgc      960

tatggtctgg gcatggagca cttgcgagag gtgagggcag ttaccagtgc caatatccag     1020

gagtttgctg gctgcaagaa gatctttggg agcctggcat ttctgccgga gagctttgat     1080

ggggacccag cctccaacac tgccccgctc cagccagagc agctccaagt gtttgagact     1140

ctggaagaga tcacaggtta cctatacatc tcagcatggc cggacagcct gcctgacctc     1200

agcgtcttcc agaacctgca agtaatccgg ggacgaattc tgcacaatgg cgcctactcg     1260

ctgaccctgc aagggctggg catcagctgg ctggggctgc gctcactgag ggaactgggc     1320

agtggactgg ccctcatcca ccataacacc cacctctgct tcgtgcacac ggtgccctgg     1380

gaccagctct ttcggaaccc gcaccaagct ctgctccaca ctgccaaccg gccagaggac     1440

gagtgtgtgg gcgagggcct ggcctgccac cagctgtgcg cccgagggca ctgctggggt     1500

ccagggccca cccagtgtgt caactgcagc cagttccttc ggggccagga gtgcgtggag     1560

gaatgccgag tactgcaggg gctccccagg gagtatgtga atgccaggca ctgtttgccg     1620

tgccaccctg agtgtcagcc ccagaatggc tcagtgacct gttttggacc ggaggctgac     1680

cagtgtgtgg cctgtgccca ctataaggac cctcccttct gcgtggcccg ctgccccagc     1740

ggtgtgaaac ctgacctctc ctacatgccc atctggaagt ttccagatga ggagggcgca     1800

tgccagcctt gccccatcaa ctgcacccac tcctgtgtgg acctggatga caagggctgc     1860

cccgccgagc agagagccag ccctctgacg tccatcatct ctgcggtggt tggcattctg     1920

ctggtcgtgg tcttgggggt ggtctttggg atcctcatca agcgacggca gcagaagatc     1980

cggaagtaca cgatgtag                                                   1998


<210>  16
<211>  1998
<212>  DNA
<213>  Mus musculus

<400>  16
acccaagtgt gtaccggtac cgacatgaag ttgcgactcc ctgccagtcc tgagacccac       60

ctggacatgc ttcgccacct ctaccagggc tgtcaggtgg tgcagggcaa tttggagctt      120

acctacctgc ccgccaatgc cagcctctca ttcctgcagg acatccagga agtccaggga      180

tacatgctca tcgctcacaa ccgagtgaaa cacgtcccac tgcagaggtt gcgcatcgtg      240

agagggactc agctctttga ggacaagtat gccctggctg tgctagacaa ccgagaccct      300

ttggacaacg tcaccaccgc cgccccaggc agaaccccag aagggctgcg ggagctgaag      360

cttcgaagtc tcacagagat cttgaaggga ggagttttga tccgtgggaa ccctcagctc      420

tgctaccagg acatggtttt gtggaaggat gtcctccgta agaataacca gctggctcct      480

gtcgacatgg acaccaatcg ttcccgggcc tgtccacctt gtgccccaac ctgcaaagac      540

aatcactgtt ggggtgagag tcctgaagac tgtcagatct tgactggcac catctgtact      600

agtggctgtg cccggtgcaa gggccggctg cccactgact gttgccatga gcagtgtgct      660

gcaggctgca cgggtcccaa gcattctgac tgcctggcct gcctccactt caatcatagt      720

ggtatctgtg agctgcactg cccggccctc atcacctaca acacagacac cttcgagtcc      780

atgctcaacc ctgagggtcg ctacaccttt ggtgccagct gtgtgaccac ctgcccctac      840

aactacctct ccacggaagt gggatcctgc actctggtct gtcccccgaa caaccaagag      900

gtcacagctg aggacggaac acagcggtgt gagaaatgca gcaagccctg tgctggagta      960

tgctatggtc tgggcatgga gcacctccga ggggcgaggg ccatcaccag tgacaatatc     1020

caggagtttg ctggctgcaa gaagatcttt gggagcctgg catttttgcc ggagagcttt     1080

gatgggaacc cctcctccgg cgttgcccca ctgaagccag agcatctcca agtgttcgaa     1140

accctggagg agatcacagg ttacctatac atttcagcat ggccagagag cttccaagac     1200

ctcagtgtct tccagaacct tcgggtcatt cggggacgga ttctccatga tggtgcttac     1260

tcattgacgt tgcaaggcct ggggattcac tcactggggc tacgctcact gcgggagctg     1320

ggcagtggat tggctctcat tcaccgcaac acccatctct gctttgtaaa cactgtacct     1380

tgggaccagc tcttccggaa cccgcaccag gccctactcc acagtgggaa ccggccagaa     1440

gaggcatgtg gtcttgaggg cttggtctgt aactcactgt gtgcccgtgg gcactgctgg     1500

gggccagggc ccacccagtg tgtcaactgc agtcagttcc tccggggcca ggagtgtgtg     1560

gaggagtgcc gagtatggaa ggggctcccc agggagtatg tgaggggcaa gcactgtctg     1620

ccatgccacc ccgagtgtca gcctcaaaac agctcggaga cctgctatgg atcggaggct     1680

gaccagtgtg aggcttgtgc ccactacaag gactcatctt cctgtgtggc tcgctgcccc     1740

agtggtgtga agccagacct ctcctacatg cctatctgga agtacccgga tgaggagggc     1800

atatgtcagc catgccccat caactgcacc cactcatgtg tggacctgga cgaacgaggc     1860

tgcccagcag agcagagagc cagcccagtg acattcatca ttgcaactgt ggtgggcgtc     1920

ctgttgttcc tgatcatagt ggtggtcatt ggaatcctaa tcaaacgaag gcgacagaag     1980

atccggaagt ataccatg                                                   1998


<210>  17
<211>  1998
<212>  DNA
<213>  Rattus norvegicus

<400>  17
acccaagtgt gtaccggcac agacatgaag ttgcggctcc ctgccagtcc tgagacccac       60

ctggacatgc tccgccacct gtaccagggc tgtcaggtag tgcagggcaa cttggagctt      120

acctacgtgc ctgccaatgc cagcctctca ttcctgcagg acatccagga agttcagggt      180

tacatgctca tcgctcacaa ccaggtgaag cgcgtcccac tgcaaaggct gcgcatcgtg      240

agagggaccc agctctttga ggacaagtat gccctggctg tgctagacaa ccgagatcct      300

caggacaatg tcgccgcctc caccccaggc agaaccccag aggggctgcg ggagctgaag      360

cttcgaagtc tcacagagat cctgaaggga ggagttttga tccgtgggaa ccctcagctc      420

tgctaccagg acatggtttt gtggaaggac gtcttccgca agaataacca actggctcct      480

gtcgatatag acaccaatcg ttcccgggcc tgtccacctt gtgcccccgc ctgcaaagac      540

aatcactgtt ggggtgagag tccggaagac tgtcagatct tgactggcac catctgtacc      600

agtggttgtg cccggtgcaa gggccggctg cccactgact gctgccatga gcagtgtgcc      660

gcaggctgca cgggccccaa gcattctgac tgcctggcct gcctccactt caatcatagt      720

ggtatctgtg agctgcactg cccagccctc gtcacctaca acacagacac ctttgagtcc      780

atgcacaacc ctgagggtcg ctacaccttt ggtgccagct gcgtgaccac ctgcccctac      840

aactacctgt ctacggaagt gggatcctgc actctggtgt gtcccccgaa taaccaagag      900

gtcacagctg aggacggaac acagcgttgt gagaaatgca gcaagccctg tgctcgagtg      960

tgctatggtc tgggcatgga gcaccttcga ggggcgaggg ccatcaccag tgacaatgtc     1020

caggagtttg atggctgcaa gaagatcttt gggagcctgg catttttgcc ggagagcttt     1080

gatggggacc cctcctccgg cattgctccg ctgaggcctg agcagctcca agtgttcgaa     1140

accctggagg agatcacagg ttacctgtac atctcagcat ggccagacag tctccgtgac     1200

ctcagtgtct tccagaacct tcgaatcatt cggggacgga ttctccacga tggcgcgtac     1260

tcattgacac tgcaaggcct ggggatccac tcgctggggc tgcgctcact gcgggagctg     1320

ggcagtggat tggctctgat tcaccgcaac gcccatctct gctttgtaca cactgtacct     1380

tgggaccagc tcttccggaa cccacatcag gccctgctcc acagtgggaa ccggccggaa     1440

gaggattgtg gtctcgaggg cttggtctgt aactcactgt gtgcccacgg gcactgctgg     1500

gggccagggc ccacccagtg tgtcaactgc agtcatttcc ttcggggcca ggagtgtgtg     1560

gaggagtgcc gagtatggaa ggggctcccc cgggagtatg tgagtgacaa gcgctgtctg     1620

ccgtgtcacc ccgagtgtca gcctcaaaac agctcagaga cctgctttgg atcggaggct     1680

gatcagtgtg cagcctgcgc ccactacaag gactcgtcct cctgtgtggc tcgctgcccc     1740

agtggtgtga aaccggacct ctcctacatg cccatctgga agtacccgga tgaggagggc     1800

atatgccagc cgtgccccat caactgcacc cactcctgtg tggatctgga tgaacgaggc     1860

tgcccagcag agcagagagc cagcccggtg acattcatca ttgcaactgt agtgggcgtc     1920

ctgctgttcc tgatcttagt ggtggtcgtt ggaatcctaa tcaaacgaag gagacagaag     1980

atccggaagt atacgatg                                                   1998


<210>  18
<211>  2004
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric human-rat E2Neu (HER2)

<400>  18
acccaagtgt gcaccggcac agacatgaag ctgcggctcc ctgccagtcc cgagacccac       60

ctggacatgc tccgccacct ctaccagggc tgccaggtgg tgcagggaaa cctggaactc      120

acctacctgc ccaccaatgc cagcctgtcc ttcctgcagg atatccagga ggtgcagggc      180

tacgtgctca tcgctcacaa ccaagtgagg caggtcccac tgcagaggct gcggattgtg      240

cgaggcaccc agctctttga ggacaactat gccctggccg tgctagacaa tggagacccg      300

ctgaacaata ccacccctgt cacaggggcc tccccaggag gcctgcggga gctgaagctt      360

cgaagcctca cagagatctt gaaaggaggg gtcttgatcc agcggaaccc ccagctctgc      420

taccaggaca cgattttgtg gaaggacatc ttccacaaga acaaccagct ggctctcaca      480

ctgatagaca ccaaccgctc tcgggcctgc cacccctgtt ctccgatgtg taagggctcc      540

cgctgctggg gagagagttc tgaggattgt cagagcctga cgcgcactgt ctgtgccggt      600

ggctgtgccc gctgcaaggg gccactgccc actgactgct gccatgagca gtgtgctgcc      660

ggctgcacgg gccccaagca ctctgactgc ctggcctgcc tccacttcaa ccacagtggc      720

atctgtgagc tgcactgccc agccctggtc acctacaaca cagacacgtt tgagtccatg      780

cccaatcccg agggccggta tacattcggc gccagctgtg tgactgcctg tccctacaac      840

tacctttcta cggacgtggg atcctgcacc ctcgtctgcc ccctgcacaa ccaagaggtg      900

acagcagagg atggaacaca gcggtgtgag aagtgcagca agccctgtgc ccgagtgtgc      960

tatggtctgg gcatggagca cttgcgagag gtgagggcag ttaccagtgc caatatccag     1020

gagtttgctg gctgcaagaa gatctttggg agcctggcat ttctgccgga gagctttgat     1080

ggggacccag cctccaacac tgccgaattc gctccgctga ggcctgagca gctccaagtg     1140

ttcgaaaccc tggaggagat cacaggttac ctgtacatct cagcatggcc agacagtctc     1200

cgtgacctca gtgtcttcca gaaccttcga atcattcggg gacggattct ccacgatggc     1260

gcgtactcat tgacactgca aggcctgggg atccactcgc tggggctgcg ctcactgcgg     1320

gagctgggca gtggattggc tctgattcac cgcaacgccc atctctgctt tgtacacact     1380

gtaccttggg accagctctt ccggaaccca catcaggccc tgctccacag tgggaaccgg     1440

ccggaagagg attgtggtct cgagggcttg gtctgtaact cactgtgtgc ccacgggcac     1500

tgctgggggc cagggcccac ccagtgtgtc aactgcagtc atttccttcg gggccaggag     1560

tgtgtggagg agtgccgagt atggaagggg ctcccccggg agtatgtgag tgacaagcgc     1620

tgtctgccgt gtcaccccga gtgtcagcct caaaacagct cagagacctg ctttggatcg     1680

gaggctgatc agtgtgcagc ctgcgcccac tacaaggact cgtcctcctg tgtggctcgc     1740

tgccccagtg gtgtgaaacc ggacctctcc tacatgccca tctggaagta cccggatgag     1800

gagggcatat gccagccgtg ccccatcaac tgcacccact cctgtgtgga tctggatgaa     1860

cgaggctgcc cagcagagca gagagccagc ccggtgacat tcatcattgc aactgtagtg     1920

ggcgtcctgc tgttcctgat cttagtggtg gtcgttggaa tcctaatcaa acgaaggaga     1980

cagaagatcc ggaagtatac gatg                                            2004


<210>  19
<211>  2061
<212>  DNA
<213>  Felis catus

<400>  19
atggagctgg cggcctggtg ccgctggggg ctcctcctcg ccctcctgcc ctccggagcc       60

acgggcaccc aagtgtgcac cggcacagac atgaagctgc ggctcccagc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgtc aagtggtaca gggcaacctg      180

gagctcacct acctgcatgc caatgccagc ctctccttcc tgcaggatat ccaggaggtg      240

caaggctatg tgctcattgc ccacaaccaa gtgaaacagg tcccactgca gaggctacga      300

atcgtgcgag gcacccagct ctttgaggac aactacgccc tggccgtgct ggacaacgga      360

gacccactgg acagtggcac ccctgctaca ggggctgccc taggagggct gcgggagctg      420

aagctccgaa gcctcacaga gatcctgaag ggaggggtcc tcattcagcg gaacccgcag      480

ctctgccacc aggacacgat tctgtggaag gacatcttcc acaagaacaa ccagctggcc      540

ctcatgctga tagacaccaa ccgctctcgg gcctgccaac cctgttctcc agcttgtaaa      600

gactcccact gctggggagc aagttccggg gactgtcaga gcttgactcg aactgtctgt      660

gctggcggct gtgcccgctg caagggcccg cagcccaccg actgctgcca cgagcaatgt      720

gctgctggct gcacgggccc caagcattct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacgga caccttcgaa      840

tccatgccca accctgaggg ccgttatacc ttcggtgcca gctgtgtgac tgcctgtccc      900

tacaactacc tgtctacgga cgtgggatcc tgcaccctgg tctgtcccct gaacaaccaa      960

gaggtgacag ctgaggatgg aacacagcgg tgtgagaaat gcagcaagcc ctgtgcccga     1020

gtgtgctacg gcctaggcat ggagcacctg cgggaggcga gggcagtcac cagtgccaac     1080

atccaagaat ttgtcggctg caagaagatc tttgggagcc tggcgtttct gccagagagc     1140

tttgaggggg acccagcctc caacactgcc cccctgcagc ctgagcagct cagagtgttt     1200

gaggctctgg aggagattac aggttacctg tacatctcag cgtggccaga cagcttgcct     1260

aacctcagtg tcttccagaa cctcagagtg atccggggcc gagttctgca tgacggtgct     1320

tactcgctga cccttcaagg gctgggcatc agctggctgg ggctgcgctc gctgcgggag     1380

ctgggcagtg ggctggccct catccaccgc aactcccgcc tctgcttcgt acacacggtg     1440

ccctgggacc agctcttccg gaacccccac caggccctgc tccacagcgc caaccggcca     1500

gaggacgagt gcgcgggtga gggcctggcc tgctatccgc tgtgtgccca cgggcactgc     1560

tggggtccgg gacccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtatt gcaggggctt ccccgggagt atgtgaagga taggttctgt     1680

ctgccatgcc acccggagtg tcagccccag aatggctcag tgacctgctt gggctcggaa     1740

gctgaccagt gtgtggcctg tgcccactac aaggaccctc ctttctgtgt ggctcgctgc     1800

cccagtgggg tgaaacctga cctctccttc atgcccatct ggaagttcgc agatgaggag     1860

ggcacgtgcc agccatgccc catcaactgc acccactcct gtgcggacct ggacgagaag     1920

ggctgccccg ccgagcagag agccagccct gtgacgtcca tcattgctgc tgtggtgggc     1980

attctgctgg tcgtggttgt ggggctggtc cttggcatcc taatcaagcg aaggcggcag     2040

aagatccgga agtacacgat g                                               2061


<210>  20
<211>  2061
<212>  DNA
<213>  Ursus americanus

<400>  20
atggagctgg cggcctggtg ccgctggggg ctcctcctcg ccctcctgcc ctccggagcc       60

gcgggcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg atatgctccg ccacctctac caggcctgtc aagtggtaca gggtaacctg      180

gagctcacct acctgcccgc caatgccagc ctgtccttcc tgcaggatat ccaggaggta      240

cagggctatg tgctcattgc tcacagccaa gtgagacagg tcccgctgca gaggctccga      300

atcgtgcgag gcacccagct ctttgaggac aactacgccc tggccgtgct ggacaatgga      360

gagccgccca agggggacac ctctgtggca ggggctaccc caggagggct gcgggagctg      420

aagcttcgaa gcctcacaga gatcctgaag ggaggggtct tgattcagcg gaacccacag      480

ctctgccacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggcc      540

ctcacgctga tagacaccaa ccgctctcgg gcctgccaac cctgttctcc agcctgtaaa      600

gacccccact gctggggagc aagttccggg gactgtcaga gcttgacacg aaccgtctgt      660

gccggcggct gtgcccgctg caagggccca aaacccactg actgctgcca tgagcagtgc      720

gcggctggct gcacgggccc caagcactcg gactgcctgg cctgccttca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacgga cacgttcgaa      840

tccatgccca accctgaggg ccgatacacc ttcggtgcca gctgtgtgac cgcctgtccc      900

tacaactacc tgtccacgga cgtgggatcc tgcaccctgg tctgtcccct gaacaaccaa      960

gaggtgacgg ctgaggatgg cacccagcgg tgtgagaaat gcagcagacc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacctg cgggaggcga gggcggtcac cagcgccaac     1080

atccaagagt tcgccggctg caagaagatc tttgggagcc tggcgtttct gccagagagc     1140

ttcgagggag acccagcctc caacactgcc cccctgcagc ctgaacagct cagagtgttc     1200

gaggccctgg aggagatcac aggttacctg tatatctcag cgtggccgga cagcttgcct     1260

aacctcagtg tcttccagaa cctgcgagta atccggggac gagttctgca tgatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc gctgcgggaa     1380

ctgggcagcg ggctggccct catccaccgc aacgcccgcc tctgcttcat ccacacggtg     1440

ccctgggagc agctcttccg gaacccccac caagccctgc tgcacagtgc caaccggccg     1500

gaggccgagt gcgtgggcga gggcctggcc tgctacccgc tgtgcgccca tgggcactgc     1560

tggggtccgg ggcccaccca gtgcgtcaac tgcagccaat tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagaact gcacgggcta ccccgggaat atgtgaagga cagatactgt     1680

ctgccatgcc accccgagtg tcggccccag aatggctcag tgacctgctt tgggtcggag     1740

gctgaccagt gtgtggcctg cgcccactac aaggaccctc cctcctgcgt ggctcgctgc     1800

cccagtggtg tgaaacccga cctctctttc atgcccattt ggaagtttgc agatgaggag     1860

ggcacatgcc agccgtgccc catcaactgc acccactcct gtggggacct ggacgagagg     1920

ggctgccccg ccgaacagag agccagccct gtgacatcca tcattgccgc tgtggtgggc     1980

attctgctgg ccgtggtcat ggggctggtc ctcggcatcc tgatcaagcg aaggcgacag     2040

aagatccgga agtacacgat g                                               2061


<210>  21
<211>  2064
<212>  DNA
<213>  Homo sapiens

<400>  21
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

aagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct ccaagtgttt     1200

gagactctgg aagagatcac aggttaccta tacatctcag catggccgga cagcctgcct     1260

gacctcagcg tcttccagaa cctgcaagta atccggggac gaattctgca caatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc actgagggaa     1380

ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt gcacacggtg     1440

ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc caaccggcca     1500

gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg agggcactgc     1560

tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc caggcactgt     1680

ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag     1740

gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc     1800

cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag     1860

ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct ggatgacaag     1920

ggctgccccg ccgagcagag agccagccct ctgacgtcca tcatctctgc ggtggttggc     1980

attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatcaagcg acggcagcag     2040

aagatccgga agtacacgat gtag                                            2064


<210>  22
<211>  2064
<212>  DNA
<213>  Mus musculus

<400>  22
atggagctgg cggcctggtg ccgttggggg ttcctcctcg ccctcctgtc ccccggagcc       60

gcgggtaccc aagtgtgtac cggtaccgac atgaagttgc gactccctgc cagtcctgag      120

acccacctgg acatgcttcg ccacctctac cagggctgtc aggtggtgca gggcaatttg      180

gagcttacct acctgcccgc caatgccagc ctctcattcc tgcaggacat ccaggaagtc      240

cagggataca tgctcatcgc tcacaaccga gtgaaacacg tcccactgca gaggttgcgc      300

atcgtgagag ggactcagct ctttgaggac aagtatgccc tggctgtgct agacaaccga      360

gaccctttgg acaacgtcac caccgccgcc ccaggcagaa ccccagaagg gctgcgggag      420

ctgaagcttc gaagtctcac agagatcttg aagggaggag ttttgatccg tgggaaccct      480

cagctctgct accaggacat ggttttgtgg aaggatgtcc tccgtaagaa taaccagctg      540

gctcctgtcg acatggacac caatcgttcc cgggcctgtc caccttgtgc cccaacctgc      600

aaagacaatc actgttgggg tgagagtcct gaagactgtc agatcttgac tggcaccatc      660

tgtactagtg gctgtgcccg gtgcaagggc cggctgccca ctgactgttg ccatgagcag      720

tgtgctgcag gctgcacggg tcccaagcat tctgactgcc tggcctgcct ccacttcaat      780

catagtggta tctgtgagct gcactgcccg gccctcatca cctacaacac agacaccttc      840

gagtccatgc tcaaccctga gggtcgctac acctttggtg ccagctgtgt gaccacctgc      900

ccctacaact acctctccac ggaagtggga tcctgcactc tggtctgtcc cccgaacaac      960

caagaggtca cagctgagga cggaacacag cggtgtgaga aatgcagcaa gccctgtgct     1020

ggagtatgct atggtctggg catggagcac ctccgagggg cgagggccat caccagtgac     1080

aatatccagg agtttgctgg ctgcaagaag atctttggga gcctggcatt tttgccggag     1140

agctttgatg ggaacccctc ctccggcgtt gccccactga agccagagca tctccaagtg     1200

ttcgaaaccc tggaggagat cacaggttac ctatacattt cagcatggcc agagagcttc     1260

caagacctca gtgtcttcca gaaccttcgg gtcattcggg gacggattct ccatgatggt     1320

gcttactcat tgacgttgca aggcctgggg attcactcac tggggctacg ctcactgcgg     1380

gagctgggca gtggattggc tctcattcac cgcaacaccc atctctgctt tgtaaacact     1440

gtaccttggg accagctctt ccggaacccg caccaggccc tactccacag tgggaaccgg     1500

ccagaagagg catgtggtct tgagggcttg gtctgtaact cactgtgtgc ccgtgggcac     1560

tgctgggggc cagggcccac ccagtgtgtc aactgcagtc agttcctccg gggccaggag     1620

tgtgtggagg agtgccgagt atggaagggg ctccccaggg agtatgtgag gggcaagcac     1680

tgtctgccat gccaccccga gtgtcagcct caaaacagct cggagacctg ctatggatcg     1740

gaggctgacc agtgtgaggc ttgtgcccac tacaaggact catcttcctg tgtggctcgc     1800

tgccccagtg gtgtgaagcc agacctctcc tacatgccta tctggaagta cccggatgag     1860

gagggcatat gtcagccatg ccccatcaac tgcacccact catgtgtgga cctggacgaa     1920

cgaggctgcc cagcagagca gagagccagc ccagtgacat tcatcattgc aactgtggtg     1980

ggcgtcctgt tgttcctgat catagtggtg gtcattggaa tcctaatcaa acgaaggcga     2040

cagaagatcc ggaagtatac catg                                            2064


<210>  23
<211>  2073
<212>  DNA
<213>  Rattus norvegicus

<400>  23
atgatcatca tggagctggc ggcctggtgc cgctgggggt tcctcctcgc cctcctgccc       60

cccggaatcg cgggcaccca agtgtgtacc ggcacagaca tgaagttgcg gctccctgcc      120

agtcctgaga cccacctgga catgctccgc cacctgtacc agggctgtca ggtagtgcag      180

ggcaacttgg agcttaccta cgtgcctgcc aatgccagcc tctcattcct gcaggacatc      240

caggaagttc agggttacat gctcatcgct cacaaccagg tgaagcgcgt cccactgcaa      300

aggctgcgca tcgtgagagg gacccagctc tttgaggaca agtatgccct ggctgtgcta      360

gacaaccgag atcctcagga caatgtcgcc gcctccaccc caggcagaac cccagagggg      420

ctgcgggagc tgaagcttcg aagtctcaca gagatcctga agggaggagt tttgatccgt      480

gggaaccctc agctctgcta ccaggacatg gttttgtgga aggacgtctt ccgcaagaat      540

aaccaactgg ctcctgtcga tatagacacc aatcgttccc gggcctgtcc accttgtgcc      600

cccgcctgca aagacaatca ctgttggggt gagagtccgg aagactgtca gatcttgact      660

ggcaccatct gtaccagtgg ttgtgcccgg tgcaagggcc ggctgcccac tgactgctgc      720

catgagcagt gtgccgcagg ctgcacgggc cccaagcatt ctgactgcct ggcctgcctc      780

cacttcaatc atagtggtat ctgtgagctg cactgcccag ccctcgtcac ctacaacaca      840

gacacctttg agtccatgca caaccctgag ggtcgctaca cctttggtgc cagctgcgtg      900

accacctgcc cctacaacta cctgtctacg gaagtgggat cctgcactct ggtgtgtccc      960

ccgaataacc aagaggtcac agctgaggac ggaacacagc gttgtgagaa atgcagcaag     1020

ccctgtgctc gagtgtgcta tggtctgggc atggagcacc ttcgaggggc gagggccatc     1080

accagtgaca atgtccagga gtttgatggc tgcaagaaga tctttgggag cctggcattt     1140

ttgccggaga gctttgatgg ggacccctcc tccggcattg ctccgctgag gcctgagcag     1200

ctccaagtgt tcgaaaccct ggaggagatc acaggttacc tgtacatctc agcatggcca     1260

gacagtctcc gtgacctcag tgtcttccag aaccttcgaa tcattcgggg acggattctc     1320

cacgatggcg cgtactcatt gacactgcaa ggcctgggga tccactcgct ggggctgcgc     1380

tcactgcggg agctgggcag tggattggct ctgattcacc gcaacgccca tctctgcttt     1440

gtacacactg taccttggga ccagctcttc cggaacccac atcaggccct gctccacagt     1500

gggaaccggc cggaagagga ttgtggtctc gagggcttgg tctgtaactc actgtgtgcc     1560

cacgggcact gctgggggcc agggcccacc cagtgtgtca actgcagtca tttccttcgg     1620

ggccaggagt gtgtggagga gtgccgagta tggaaggggc tcccccggga gtatgtgagt     1680

gacaagcgct gtctgccgtg tcaccccgag tgtcagcctc aaaacagctc agagacctgc     1740

tttggatcgg aggctgatca gtgtgcagcc tgcgcccact acaaggactc gtcctcctgt     1800

gtggctcgct gccccagtgg tgtgaaaccg gacctctcct acatgcccat ctggaagtac     1860

ccggatgagg agggcatatg ccagccgtgc cccatcaact gcacccactc ctgtgtggat     1920

ctggatgaac gaggctgccc agcagagcag agagccagcc cggtgacatt catcattgca     1980

actgtagtgg gcgtcctgct gttcctgatc ttagtggtgg tcgttggaat cctaatcaaa     2040

cgaaggagac agaagatccg gaagtatacg atg                                  2073


<210>  24
<211>  2070
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric human-rat E2Neu (HER2)

<400>  24
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

aagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc gaattcgctc cgctgaggcc tgagcagctc     1200

caagtgttcg aaaccctgga ggagatcaca ggttacctgt acatctcagc atggccagac     1260

agtctccgtg acctcagtgt cttccagaac cttcgaatca ttcggggacg gattctccac     1320

gatggcgcgt actcattgac actgcaaggc ctggggatcc actcgctggg gctgcgctca     1380

ctgcgggagc tgggcagtgg attggctctg attcaccgca acgcccatct ctgctttgta     1440

cacactgtac cttgggacca gctcttccgg aacccacatc aggccctgct ccacagtggg     1500

aaccggccgg aagaggattg tggtctcgag ggcttggtct gtaactcact gtgtgcccac     1560

gggcactgct gggggccagg gcccacccag tgtgtcaact gcagtcattt ccttcggggc     1620

caggagtgtg tggaggagtg ccgagtatgg aaggggctcc cccgggagta tgtgagtgac     1680

aagcgctgtc tgccgtgtca ccccgagtgt cagcctcaaa acagctcaga gacctgcttt     1740

ggatcggagg ctgatcagtg tgcagcctgc gcccactaca aggactcgtc ctcctgtgtg     1800

gctcgctgcc ccagtggtgt gaaaccggac ctctcctaca tgcccatctg gaagtacccg     1860

gatgaggagg gcatatgcca gccgtgcccc atcaactgca cccactcctg tgtggatctg     1920

gatgaacgag gctgcccagc agagcagaga gccagcccgg tgacattcat cattgcaact     1980

gtagtgggcg tcctgctgtt cctgatctta gtggtggtcg ttggaatcct aatcaaacga     2040

aggagacaga agatccggaa gtatacgatg                                      2070


<210>  25
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  25

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  


Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
            100                 105                 110         


Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
    130                 135                 140                 


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
145                 150                 155                 160 


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
                165                 170                 175     


Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
            180                 185                 190         


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             


Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             


Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 


Gly Thr Lys Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
                325                 330                 335     


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         


Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             


Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile 
    370                 375                 380                 


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu 
385                 390                 395                 400 


Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn 
                405                 410                 415     


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
            420                 425                 430         


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His 
        435                 440                 445             


Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
    450                 455                 460                 


Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp 
465                 470                 475                 480 


Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly 
                485                 490                 495     


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
            500                 505                 510         


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
        515                 520                 525             


Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu 
    530                 535                 540                 


Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp 
545                 550                 555                 560 


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
                565                 570                 575     


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp 
            580                 585                 590         


Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys 
        595                 600                 605             


Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln 
    610                 615                 620                 


Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val Gly Ile Leu 
625                 630                 635                 640 


Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Lys Arg Arg 
                645                 650                 655     


Gln Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665 


<210>  26
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  26

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  


Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
            100                 105                 110         


Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
    130                 135                 140                 


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
145                 150                 155                 160 


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
                165                 170                 175     


Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
            180                 185                 190         


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             


Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             


Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
                325                 330                 335     


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         


Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             


Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile 
    370                 375                 380                 


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu 
385                 390                 395                 400 


Ser Val Phe Gln Asn Leu Arg Val Ile Arg Gly Arg Ile Leu His Asn 
                405                 410                 415     


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
            420                 425                 430         


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His 
        435                 440                 445             


Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
    450                 455                 460                 


Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp 
465                 470                 475                 480 


Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly 
                485                 490                 495     


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
            500                 505                 510         


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
        515                 520                 525             


Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu 
    530                 535                 540                 


Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp 
545                 550                 555                 560 


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
                565                 570                 575     


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp 
            580                 585                 590         


Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys 
        595                 600                 605             


Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln 
    610                 615                 620                 


Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val Gly Ile Leu 
625                 630                 635                 640 


Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Lys Arg Arg 
                645                 650                 655     


Gln Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665 


<210>  27
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  27

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  


Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
            100                 105                 110         


Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
    130                 135                 140                 


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
145                 150                 155                 160 


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
                165                 170                 175     


Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
            180                 185                 190         


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             


Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             


Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
                325                 330                 335     


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         


Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             


Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile 
    370                 375                 380                 


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu 
385                 390                 395                 400 


Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asp 
                405                 410                 415     


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
            420                 425                 430         


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His 
        435                 440                 445             


Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
    450                 455                 460                 


Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp 
465                 470                 475                 480 


Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly 
                485                 490                 495     


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
            500                 505                 510         


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
        515                 520                 525             


Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu 
    530                 535                 540                 


Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp 
545                 550                 555                 560 


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
                565                 570                 575     


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp 
            580                 585                 590         


Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys 
        595                 600                 605             


Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln 
    610                 615                 620                 


Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val Gly Ile Leu 
625                 630                 635                 640 


Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Lys Arg Arg 
                645                 650                 655     


Gln Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665 


<210>  28
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Lys Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 
        675                 680                 685         


<210>  29
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Arg Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 
        675                 680                 685         


<210>  30
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 
        675                 680                 685         


<210>  31
<211>  1998
<212>  DNA
<213>  Homo sapiens

<400>  31
acccaagtgt gcaccggcac agacatgaag ctgcggctcc ctgccagtcc cgagacccac       60

ctggacatgc tccgccacct ctaccagggc tgccaggtgg tgcagggaaa cctggaactc      120

acctacctgc ccaccaatgc cagcctgtcc ttcctgcagg atatccagga ggtgcagggc      180

tacgtgctca tcgctcacaa ccaagtgagg caggtcccac tgcagaggct gcggattgtg      240

cgaggcaccc agctctttga ggacaactat gccctggccg tgctagacaa tggagacccg      300

ctgaacaata ccacccctgt cacaggggcc tccccaggag gcctgcggga gctgcagctt      360

cgaagcctca cagagatctt gaaaggaggg gtcttgatcc agcggaaccc ccagctctgc      420

taccaggaca cgattttgtg gaaggacatc ttccacaaga acaaccagct ggctctcaca      480

ctgatagaca ccaaccgctc tcgggcctgc cacccctgtt ctccgatgtg taagggctcc      540

cgctgctggg gagagagttc tgaggattgt cagagcctga cgcgcactgt ctgtgccggt      600

ggctgtgccc gctgcaaggg gccactgccc actgactgct gccatgagca gtgtgctgcc      660

ggctgcacgg gccccaagca ctctgactgc ctggcctgcc tccacttcaa ccacagtggc      720

atctgtgagc tgcactgccc agccctggtc acctacaaca cagacacgtt tgagtccatg      780

cccaatcccg agggccggta tacattcggc gccagctgtg tgactgcctg tccctacaac      840

tacctttcta cggacgtggg atcctgcacc ctcgtctgcc ccctgcacaa ccaagaggtg      900

acagcagagg atggaacaaa gcggtgtgag aagtgcagca agccctgtgc ccgagtgtgc      960

tatggtctgg gcatggagca cttgcgagag gtgagggcag ttaccagtgc caatatccag     1020

gagtttgctg gctgcaagaa gatctttggg agcctggcat ttctgccgga gagctttgat     1080

ggggacccag cctccaacac tgccccgctc cagccagagc agctccaagt gtttgagact     1140

ctggaagaga tcacaggtta cctatacatc tcagcatggc cggacagcct gcctgacctc     1200

agcgtcttcc agaacctgca agtaatccgg ggacgaattc tgcacaatgg cgcctactcg     1260

ctgaccctgc aagggctggg catcagctgg ctggggctgc gctcactgag ggaactgggc     1320

agtggactgg ccctcatcca ccataacacc cacctctgct tcgtgcacac ggtgccctgg     1380

gaccagctct ttcggaaccc gcaccaagct ctgctccaca ctgccaaccg gccagaggac     1440

gagtgtgtgg gcgagggcct ggcctgccac cagctgtgcg cccgagggca ctgctggggt     1500

ccagggccca cccagtgtgt caactgcagc cagttccttc ggggccagga gtgcgtggag     1560

gaatgccgag tactgcaggg gctccccagg gagtatgtga atgccaggca ctgtttgccg     1620

tgccaccctg agtgtcagcc ccagaatggc tcagtgacct gttttggacc ggaggctgac     1680

cagtgtgtgg cctgtgccca ctataaggac cctcccttct gcgtggcccg ctgccccagc     1740

ggtgtgaaac ctgacctctc ctacatgccc atctggaagt ttccagatga ggagggcgca     1800

tgccagcctt gccccatcaa ctgcacccac tcctgtgtgg acctggatga caagggctgc     1860

cccgccgagc agagagccag ccctctgacg tccatcatct ctgcggtggt tggcattctg     1920

ctggtcgtgg tcttgggggt ggtctttggg atcctcatca agcgacggca gcagaagatc     1980

cggaagtaca cgatgtga                                                   1998


<210>  32
<211>  1998
<212>  DNA
<213>  Homo sapiens

<400>  32
acccaagtgt gcaccggcac agacatgaag ctgcggctcc ctgccagtcc cgagacccac       60

ctggacatgc tccgccacct ctaccagggc tgccaggtgg tgcagggaaa cctggaactc      120

acctacctgc ccaccaatgc cagcctgtcc ttcctgcagg atatccagga ggtgcagggc      180

tacgtgctca tcgctcacaa ccaagtgagg caggtcccac tgcagaggct gcggattgtg      240

cgaggcaccc agctctttga ggacaactat gccctggccg tgctagacaa tggagacccg      300

ctgaacaata ccacccctgt cacaggggcc tccccaggag gcctgcggga gctgcagctt      360

cgaagcctca cagagatctt gaaaggaggg gtcttgatcc agcggaaccc ccagctctgc      420

taccaggaca cgattttgtg gaaggacatc ttccacaaga acaaccagct ggctctcaca      480

ctgatagaca ccaaccgctc tcgggcctgc cacccctgtt ctccgatgtg taagggctcc      540

cgctgctggg gagagagttc tgaggattgt cagagcctga cgcgcactgt ctgtgccggt      600

ggctgtgccc gctgcaaggg gccactgccc actgactgct gccatgagca gtgtgctgcc      660

ggctgcacgg gccccaagca ctctgactgc ctggcctgcc tccacttcaa ccacagtggc      720

atctgtgagc tgcactgccc agccctggtc acctacaaca cagacacgtt tgagtccatg      780

cccaatcccg agggccggta tacattcggc gccagctgtg tgactgcctg tccctacaac      840

tacctttcta cggacgtggg atcctgcacc ctcgtctgcc ccctgcacaa ccaagaggtg      900

acagcagagg atggaacaca gcggtgtgag aagtgcagca agccctgtgc ccgagtgtgc      960

tatggtctgg gcatggagca cttgcgagag gtgagggcag ttaccagtgc caatatccag     1020

gagtttgctg gctgcaagaa gatctttggg agcctggcat ttctgccgga gagctttgat     1080

ggggacccag cctccaacac tgccccgctc cagccagagc agctccaagt gtttgagact     1140

ctggaagaga tcacaggtta cctatacatc tcagcatggc cggacagcct gcctgacctc     1200

agcgtcttcc agaacctgag agtaatccgg ggacgaattc tgcacaatgg cgcctactcg     1260

ctgaccctgc aagggctggg catcagctgg ctggggctgc gctcactgag ggaactgggc     1320

agtggactgg ccctcatcca ccataacacc cacctctgct tcgtgcacac ggtgccctgg     1380

gaccagctct ttcggaaccc gcaccaagct ctgctccaca ctgccaaccg gccagaggac     1440

gagtgtgtgg gcgagggcct ggcctgccac cagctgtgcg cccgagggca ctgctggggt     1500

ccagggccca cccagtgtgt caactgcagc cagttccttc ggggccagga gtgcgtggag     1560

gaatgccgag tactgcaggg gctccccagg gagtatgtga atgccaggca ctgtttgccg     1620

tgccaccctg agtgtcagcc ccagaatggc tcagtgacct gttttggacc ggaggctgac     1680

cagtgtgtgg cctgtgccca ctataaggac cctcccttct gcgtggcccg ctgccccagc     1740

ggtgtgaaac ctgacctctc ctacatgccc atctggaagt ttccagatga ggagggcgca     1800

tgccagcctt gccccatcaa ctgcacccac tcctgtgtgg acctggatga caagggctgc     1860

cccgccgagc agagagccag ccctctgacg tccatcatct ctgcggtggt tggcattctg     1920

ctggtcgtgg tcttgggggt ggtctttggg atcctcatca agcgacggca gcagaagatc     1980

cggaagtaca cgatgtga                                                   1998


<210>  33
<211>  1998
<212>  DNA
<213>  Homo sapiens

<400>  33
acccaagtgt gcaccggcac agacatgaag ctgcggctcc ctgccagtcc cgagacccac       60

ctggacatgc tccgccacct ctaccagggc tgccaggtgg tgcagggaaa cctggaactc      120

acctacctgc ccaccaatgc cagcctgtcc ttcctgcagg atatccagga ggtgcagggc      180

tacgtgctca tcgctcacaa ccaagtgagg caggtcccac tgcagaggct gcggattgtg      240

cgaggcaccc agctctttga ggacaactat gccctggccg tgctagacaa tggagacccg      300

ctgaacaata ccacccctgt cacaggggcc tccccaggag gcctgcggga gctgcagctt      360

cgaagcctca cagagatctt gaaaggaggg gtcttgatcc agcggaaccc ccagctctgc      420

taccaggaca cgattttgtg gaaggacatc ttccacaaga acaaccagct ggctctcaca      480

ctgatagaca ccaaccgctc tcgggcctgc cacccctgtt ctccgatgtg taagggctcc      540

cgctgctggg gagagagttc tgaggattgt cagagcctga cgcgcactgt ctgtgccggt      600

ggctgtgccc gctgcaaggg gccactgccc actgactgct gccatgagca gtgtgctgcc      660

ggctgcacgg gccccaagca ctctgactgc ctggcctgcc tccacttcaa ccacagtggc      720

atctgtgagc tgcactgccc agccctggtc acctacaaca cagacacgtt tgagtccatg      780

cccaatcccg agggccggta tacattcggc gccagctgtg tgactgcctg tccctacaac      840

tacctttcta cggacgtggg atcctgcacc ctcgtctgcc ccctgcacaa ccaagaggtg      900

acagcagagg atggaacaca gcggtgtgag aagtgcagca agccctgtgc ccgagtgtgc      960

tatggtctgg gcatggagca cttgcgagag gtgagggcag ttaccagtgc caatatccag     1020

gagtttgctg gctgcaagaa gatctttggg agcctggcat ttctgccgga gagctttgat     1080

ggggacccag cctccaacac tgccccgctc cagccagagc agctccaagt gtttgagact     1140

ctggaagaga tcacaggtta cctatacatc tcagcatggc cggacagcct gcctgacctc     1200

agcgtcttcc agaacctgca agtaatccgg ggacgaattc tgcacgatgg cgcctactcg     1260

ctgaccctgc aagggctggg catcagctgg ctggggctgc gctcactgag ggaactgggc     1320

agtggactgg ccctcatcca ccataacacc cacctctgct tcgtgcacac ggtgccctgg     1380

gaccagctct ttcggaaccc gcaccaagct ctgctccaca ctgccaaccg gccagaggac     1440

gagtgtgtgg gcgagggcct ggcctgccac cagctgtgcg cccgagggca ctgctggggt     1500

ccagggccca cccagtgtgt caactgcagc cagttccttc ggggccagga gtgcgtggag     1560

gaatgccgag tactgcaggg gctccccagg gagtatgtga atgccaggca ctgtttgccg     1620

tgccaccctg agtgtcagcc ccagaatggc tcagtgacct gttttggacc ggaggctgac     1680

cagtgtgtgg cctgtgccca ctataaggac cctcccttct gcgtggcccg ctgccccagc     1740

ggtgtgaaac ctgacctctc ctacatgccc atctggaagt ttccagatga ggagggcgca     1800

tgccagcctt gccccatcaa ctgcacccac tcctgtgtgg acctggatga caagggctgc     1860

cccgccgagc agagagccag ccctctgacg tccatcatct ctgcggtggt tggcattctg     1920

ctggtcgtgg tcttgggggt ggtctttggg atcctcatca agcgacggca gcagaagatc     1980

cggaagtaca cgatgtga                                                   1998


<210>  34
<211>  2064
<212>  DNA
<213>  Homo sapiens

<400>  34
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacaaagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct ccaagtgttt     1200

gagactctgg aagagatcac aggttaccta tacatctcag catggccgga cagcctgcct     1260

gacctcagcg tcttccagaa cctgcaagta atccggggac gaattctgca caatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc actgagggaa     1380

ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt gcacacggtg     1440

ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc caaccggcca     1500

gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg agggcactgc     1560

tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc caggcactgt     1680

ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag     1740

gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc     1800

cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag     1860

ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct ggatgacaag     1920

ggctgccccg ccgagcagag agccagccct ctgacgtcca tcatctctgc ggtggttggc     1980

attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatcaagcg acggcagcag     2040

aagatccgga agtacacgat gtga                                            2064


<210>  35
<211>  2064
<212>  DNA
<213>  Homo sapiens

<400>  35
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct ccaagtgttt     1200

gagactctgg aagagatcac aggttaccta tacatctcag catggccgga cagcctgcct     1260

gacctcagcg tcttccagaa cctgagagta atccggggac gaattctgca caatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc actgagggaa     1380

ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt gcacacggtg     1440

ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc caaccggcca     1500

gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg agggcactgc     1560

tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc caggcactgt     1680

ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag     1740

gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc     1800

cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag     1860

ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct ggatgacaag     1920

ggctgccccg ccgagcagag agccagccct ctgacgtcca tcatctctgc ggtggttggc     1980

attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatcaagcg acggcagcag     2040

aagatccgga agtacacgat gtga                                            2064


<210>  36
<211>  2064
<212>  DNA
<213>  Homo sapiens

<400>  36
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct ccaagtgttt     1200

gagactctgg aagagatcac aggttaccta tacatctcag catggccgga cagcctgcct     1260

gacctcagcg tcttccagaa cctgcaagta atccggggac gaattctgca cgatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc actgagggaa     1380

ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt gcacacggtg     1440

ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc caaccggcca     1500

gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg agggcactgc     1560

tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc caggcactgt     1680

ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag     1740

gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc     1800

cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag     1860

ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct ggatgacaag     1920

ggctgccccg ccgagcagag agccagccct ctgacgtcca tcatctctgc ggtggttggc     1980

attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatcaagcg acggcagcag     2040

aagatccgga agtacacgat gtga                                            2064


<210>  37
<211>  687
<212>  PRT
<213>  Ursus americanus

<400>  37

Met Glu Leu Ala Ala Trp Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Ser Gly Ala Ala Gly Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Ala Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Ala Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Ser Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Glu Pro Pro Lys Gly Asp Thr Ser 
        115                 120                 125             


Val Ala Gly Ala Thr Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys His Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


Gln Pro Cys Ser Pro Ala Cys Lys Asp Pro His Cys Trp Gly Ala Ser 
        195                 200                 205             


Ser Gly Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Lys Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu Asn Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Arg 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Ala Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Glu Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Arg Val Phe 
385                 390                 395                 400 


Glu Ala Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asn Leu Ser Val Phe Gln Asn Leu Arg Val Ile Arg 
            420                 425                 430         


Gly Arg Val Leu His Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His Arg Asn Ala Arg Leu Cys Phe Ile His Thr Val 
465                 470                 475                 480 


Pro Trp Glu Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Ser 
                485                 490                 495     


Ala Asn Arg Pro Glu Ala Glu Cys Val Gly Glu Gly Leu Ala Cys Tyr 
            500                 505                 510         


Pro Leu Cys Ala His Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Glu Leu His Gly Leu Pro Arg Glu Tyr Val Lys Asp Arg Tyr Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Arg Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Ser Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Ser Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Phe Met Pro Ile Trp Lys Phe Ala Asp Glu Glu Gly Thr Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Gly Asp Leu Asp Glu Arg 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Val Thr Ser Ile Ile Ala 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Ala Val Val Met Gly Leu Val Leu Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Arg Gln Lys Ile Arg Lys Tyr Thr Met 
        675                 680                 685         


<210>  38
<211>  665
<212>  PRT
<213>  Ursus americanus

<400>  38

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Ala Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Ala Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  


Ala His Ser Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Gly Glu Pro Pro Lys Gly Asp Thr Ser Val Ala Gly Ala Thr Pro 
            100                 105                 110         


Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys His Gln Asp Thr 
    130                 135                 140                 


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
145                 150                 155                 160 


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys Gln Pro Cys Ser Pro Ala 
                165                 170                 175     


Cys Lys Asp Pro His Cys Trp Gly Ala Ser Ser Gly Asp Cys Gln Ser 
            180                 185                 190         


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             


Lys Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             


Cys Thr Leu Val Cys Pro Leu Asn Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 


Gly Thr Gln Arg Cys Glu Lys Cys Ser Arg Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Ala Arg Ala Val Thr Ser 
                325                 330                 335     


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         


Ala Phe Leu Pro Glu Ser Phe Glu Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             


Pro Leu Gln Pro Glu Gln Leu Arg Val Phe Glu Ala Leu Glu Glu Ile 
    370                 375                 380                 


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asn Leu 
385                 390                 395                 400 


Ser Val Phe Gln Asn Leu Arg Val Ile Arg Gly Arg Val Leu His Asp 
                405                 410                 415     


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
            420                 425                 430         


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His Arg 
        435                 440                 445             


Asn Ala Arg Leu Cys Phe Ile His Thr Val Pro Trp Glu Gln Leu Phe 
    450                 455                 460                 


Arg Asn Pro His Gln Ala Leu Leu His Ser Ala Asn Arg Pro Glu Ala 
465                 470                 475                 480 


Glu Cys Val Gly Glu Gly Leu Ala Cys Tyr Pro Leu Cys Ala His Gly 
                485                 490                 495     


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
            500                 505                 510         


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Glu Leu His Gly Leu 
        515                 520                 525             


Pro Arg Glu Tyr Val Lys Asp Arg Tyr Cys Leu Pro Cys His Pro Glu 
    530                 535                 540                 


Cys Arg Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Ser Glu Ala Asp 
545                 550                 555                 560 


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Ser Cys Val Ala 
                565                 570                 575     


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Phe Met Pro Ile Trp 
            580                 585                 590         


Lys Phe Ala Asp Glu Glu Gly Thr Cys Gln Pro Cys Pro Ile Asn Cys 
        595                 600                 605             


Thr His Ser Cys Gly Asp Leu Asp Glu Arg Gly Cys Pro Ala Glu Gln 
    610                 615                 620                 


Arg Ala Ser Pro Val Thr Ser Ile Ile Ala Ala Val Val Gly Ile Leu 
625                 630                 635                 640 


Leu Ala Val Val Met Gly Leu Val Leu Gly Ile Leu Ile Lys Arg Arg 
                645                 650                 655     


Arg Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665 


<210>  39
<211>  687
<212>  PRT
<213>  Felis catus

<400>  39

Met Glu Leu Ala Ala Trp Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Ser Gly Ala Thr Gly Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu His Ala Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Lys Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asp Ser Gly Thr Pro 
        115                 120                 125             


Ala Thr Gly Ala Ala Leu Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys His Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Met Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


Gln Pro Cys Ser Pro Ala Cys Lys Asp Ser His Cys Trp Gly Ala Ser 
        195                 200                 205             


Ser Gly Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Gln Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu Asn Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Ala Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Val Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Glu Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Arg Val Phe 
385                 390                 395                 400 


Glu Ala Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asn Leu Ser Val Phe Gln Asn Leu Arg Val Ile Arg 
            420                 425                 430         


Gly Arg Val Leu His Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His Arg Asn Ser Arg Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Ser 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Ala Gly Glu Gly Leu Ala Cys Tyr 
            500                 505                 510         


Pro Leu Cys Ala His Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Lys Asp Arg Phe Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Leu Gly Ser Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Phe Met Pro Ile Trp Lys Phe Ala Asp Glu Glu Gly Thr Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Ala Asp Leu Asp Glu Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Val Thr Ser Ile Ile Ala 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Val Gly Leu Val Leu Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Arg Gln Lys Ile Arg Lys Tyr Thr Met 
        675                 680                 685         


<210>  40
<211>  665
<212>  PRT
<213>  Felis catus

<400>  40

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu His Ala Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  


Ala His Asn Gln Val Lys Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Gly Asp Pro Leu Asp Ser Gly Thr Pro Ala Thr Gly Ala Ala Leu 
            100                 105                 110         


Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys His Gln Asp Thr 
    130                 135                 140                 


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Met 
145                 150                 155                 160 


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys Gln Pro Cys Ser Pro Ala 
                165                 170                 175     


Cys Lys Asp Ser His Cys Trp Gly Ala Ser Ser Gly Asp Cys Gln Ser 
            180                 185                 190         


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             


Gln Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             


Cys Thr Leu Val Cys Pro Leu Asn Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Ala Arg Ala Val Thr Ser 
                325                 330                 335     


Ala Asn Ile Gln Glu Phe Val Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         


Ala Phe Leu Pro Glu Ser Phe Glu Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             


Pro Leu Gln Pro Glu Gln Leu Arg Val Phe Glu Ala Leu Glu Glu Ile 
    370                 375                 380                 


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asn Leu 
385                 390                 395                 400 


Ser Val Phe Gln Asn Leu Arg Val Ile Arg Gly Arg Val Leu His Asp 
                405                 410                 415     


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
            420                 425                 430         


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His Arg 
        435                 440                 445             


Asn Ser Arg Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
    450                 455                 460                 


Arg Asn Pro His Gln Ala Leu Leu His Ser Ala Asn Arg Pro Glu Asp 
465                 470                 475                 480 


Glu Cys Ala Gly Glu Gly Leu Ala Cys Tyr Pro Leu Cys Ala His Gly 
                485                 490                 495     


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
            500                 505                 510         


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
        515                 520                 525             


Pro Arg Glu Tyr Val Lys Asp Arg Phe Cys Leu Pro Cys His Pro Glu 
    530                 535                 540                 


Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Leu Gly Ser Glu Ala Asp 
545                 550                 555                 560 


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
                565                 570                 575     


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Phe Met Pro Ile Trp 
            580                 585                 590         


Lys Phe Ala Asp Glu Glu Gly Thr Cys Gln Pro Cys Pro Ile Asn Cys 
        595                 600                 605             


Thr His Ser Cys Ala Asp Leu Asp Glu Lys Gly Cys Pro Ala Glu Gln 
    610                 615                 620                 


Arg Ala Ser Pro Val Thr Ser Ile Ile Ala Ala Val Val Gly Ile Leu 
625                 630                 635                 640 


Leu Val Val Val Val Gly Leu Val Leu Gly Ile Leu Ile Lys Arg Arg 
                645                 650                 655     


Arg Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665 


<210>  41
<211>  2061
<212>  DNA
<213>  Ursus americanus

<400>  41
atggagctgg cggcctggtg ccgctggggg ctcctcctcg ccctcctgcc ctccggagcc       60

gcgggcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg atatgctccg ccacctctac caggcctgtc aagtggtaca gggtaacctg      180

gagctcacct acctgcccgc caatgccagc ctgtccttcc tgcaggatat ccaggaggta      240

cagggctatg tgctcattgc tcacagccaa gtgagacagg tcccgctgca gaggctccga      300

atcgtgcgag gcacccagct ctttgaggac aactacgccc tggccgtgct ggacaatgga      360

gagccgccca agggggacac ctctgtggca ggggctaccc caggagggct gcgggagctg      420

cagcttcgaa gcctcacaga gatcctgaag ggaggggtct tgattcagcg gaacccacag      480

ctctgccacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggcc      540

ctcacgctga tagacaccaa ccgctctcgg gcctgccaac cctgttctcc agcctgtaaa      600

gacccccact gctggggagc aagttccggg gactgtcaga gcttgacacg aaccgtctgt      660

gccggcggct gtgcccgctg caagggccca aaacccactg actgctgcca tgagcagtgc      720

gcggctggct gcacgggccc caagcactcg gactgcctgg cctgccttca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacgga cacgttcgaa      840

tccatgccca accctgaggg ccgatacacc ttcggtgcca gctgtgtgac cgcctgtccc      900

tacaactacc tgtccacgga cgtgggatcc tgcaccctgg tctgtcccct gaacaaccaa      960

gaggtgacgg ctgaggatgg cacccagcgg tgtgagaaat gcagcagacc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacctg cgggaggcga gggcggtcac cagcgccaac     1080

atccaagagt tcgccggctg caagaagatc tttgggagcc tggcgtttct gccagagagc     1140

ttcgagggag acccagcctc caacactgcc cccctgcagc ctgaacagct cagagtgttc     1200

gaggccctgg aggagatcac aggttacctg tatatctcag cgtggccgga cagcttgcct     1260

aacctcagtg tcttccagaa cctgcgagta atccggggac gagttctgca tgatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc gctgcgggaa     1380

ctgggcagcg ggctggccct catccaccgc aacgcccgcc tctgcttcat ccacacggtg     1440

ccctgggagc agctcttccg gaacccccac caagccctgc tgcacagtgc caaccggccg     1500

gaggccgagt gcgtgggcga gggcctggcc tgctacccgc tgtgcgccca tgggcactgc     1560

tggggtccgg ggcccaccca gtgcgtcaac tgcagccaat tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagaact gcacgggcta ccccgggaat atgtgaagga cagatactgt     1680

ctgccatgcc accccgagtg tcggccccag aatggctcag tgacctgctt tgggtcggag     1740

gctgaccagt gtgtggcctg cgcccactac aaggaccctc cctcctgcgt ggctcgctgc     1800

cccagtggtg tgaaacccga cctctctttc atgcccattt ggaagtttgc agatgaggag     1860

ggcacatgcc agccgtgccc catcaactgc acccactcct gtggggacct ggacgagagg     1920

ggctgccccg ccgaacagag agccagccct gtgacatcca tcattgccgc tgtggtgggc     1980

attctgctgg ccgtggtcat ggggctggtc ctcggcatcc tgatcaagcg aaggcgacag     2040

aagatccgga agtacacgat g                                               2061


<210>  42
<211>  1995
<212>  DNA
<213>  Ursus americanus

<400>  42
acccaagtgt gcaccggcac agacatgaag ctgcggctcc ctgccagtcc cgagacccac       60

ctggatatgc tccgccacct ctaccaggcc tgtcaagtgg tacagggtaa cctggagctc      120

acctacctgc ccgccaatgc cagcctgtcc ttcctgcagg atatccagga ggtacagggc      180

tatgtgctca ttgctcacag ccaagtgaga caggtcccgc tgcagaggct ccgaatcgtg      240

cgaggcaccc agctctttga ggacaactac gccctggccg tgctggacaa tggagagccg      300

cccaaggggg acacctctgt ggcaggggct accccaggag ggctgcggga gctgcagctt      360

cgaagcctca cagagatcct gaagggaggg gtcttgattc agcggaaccc acagctctgc      420

caccaggaca cgattttgtg gaaggacatc ttccacaaga acaaccagct ggccctcacg      480

ctgatagaca ccaaccgctc tcgggcctgc caaccctgtt ctccagcctg taaagacccc      540

cactgctggg gagcaagttc cggggactgt cagagcttga cacgaaccgt ctgtgccggc      600

ggctgtgccc gctgcaaggg cccaaaaccc actgactgct gccatgagca gtgcgcggct      660

ggctgcacgg gccccaagca ctcggactgc ctggcctgcc ttcacttcaa ccacagtggc      720

atctgtgagc tgcactgccc agccctggtc acctacaaca cggacacgtt cgaatccatg      780

cccaaccctg agggccgata caccttcggt gccagctgtg tgaccgcctg tccctacaac      840

tacctgtcca cggacgtggg atcctgcacc ctggtctgtc ccctgaacaa ccaagaggtg      900

acggctgagg atggcaccca gcggtgtgag aaatgcagca gaccctgtgc ccgagtgtgc      960

tatggtctgg gcatggagca cctgcgggag gcgagggcgg tcaccagcgc caacatccaa     1020

gagttcgccg gctgcaagaa gatctttggg agcctggcgt ttctgccaga gagcttcgag     1080

ggagacccag cctccaacac tgcccccctg cagcctgaac agctcagagt gttcgaggcc     1140

ctggaggaga tcacaggtta cctgtatatc tcagcgtggc cggacagctt gcctaacctc     1200

agtgtcttcc agaacctgcg agtaatccgg ggacgagttc tgcatgatgg cgcctactcg     1260

ctgaccctgc aagggctggg catcagctgg ctggggctgc gctcgctgcg ggaactgggc     1320

agcgggctgg ccctcatcca ccgcaacgcc cgcctctgct tcatccacac ggtgccctgg     1380

gagcagctct tccggaaccc ccaccaagcc ctgctgcaca gtgccaaccg gccggaggcc     1440

gagtgcgtgg gcgagggcct ggcctgctac ccgctgtgcg cccatgggca ctgctggggt     1500

ccggggccca cccagtgcgt caactgcagc caattccttc ggggccagga gtgcgtggag     1560

gaatgccgag aactgcacgg gctaccccgg gaatatgtga aggacagata ctgtctgcca     1620

tgccaccccg agtgtcggcc ccagaatggc tcagtgacct gctttgggtc ggaggctgac     1680

cagtgtgtgg cctgcgccca ctacaaggac cctccctcct gcgtggctcg ctgccccagt     1740

ggtgtgaaac ccgacctctc tttcatgccc atttggaagt ttgcagatga ggagggcaca     1800

tgccagccgt gccccatcaa ctgcacccac tcctgtgggg acctggacga gaggggctgc     1860

cccgccgaac agagagccag ccctgtgaca tccatcattg ccgctgtggt gggcattctg     1920

ctggccgtgg tcatggggct ggtcctcggc atcctgatca agcgaaggcg acagaagatc     1980

cggaagtaca cgatg                                                      1995


<210>  43
<211>  2061
<212>  DNA
<213>  Felis catus

<400>  43
atggagctgg cggcctggtg ccgctggggg ctcctcctcg ccctcctgcc ctccggagcc       60

acgggcaccc aagtgtgcac cggcacagac atgaagctgc ggctcccagc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgtc aagtggtaca gggcaacctg      180

gagctcacct acctgcatgc caatgccagc ctctccttcc tgcaggatat ccaggaggtg      240

caaggctatg tgctcattgc ccacaaccaa gtgaaacagg tcccactgca gaggctacga      300

atcgtgcgag gcacccagct ctttgaggac aactacgccc tggccgtgct ggacaacgga      360

gacccactgg acagtggcac ccctgctaca ggggctgccc taggagggct gcgggagctg      420

cagctccgaa gcctcacaga gatcctgaag ggaggggtcc tcattcagcg gaacccgcag      480

ctctgccacc aggacacgat tctgtggaag gacatcttcc acaagaacaa ccagctggcc      540

ctcatgctga tagacaccaa ccgctctcgg gcctgccaac cctgttctcc agcttgtaaa      600

gactcccact gctggggagc aagttccggg gactgtcaga gcttgactcg aactgtctgt      660

gctggcggct gtgcccgctg caagggcccg cagcccaccg actgctgcca cgagcaatgt      720

gctgctggct gcacgggccc caagcattct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacgga caccttcgaa      840

tccatgccca accctgaggg ccgttatacc ttcggtgcca gctgtgtgac tgcctgtccc      900

tacaactacc tgtctacgga cgtgggatcc tgcaccctgg tctgtcccct gaacaaccaa      960

gaggtgacag ctgaggatgg aacacagcgg tgtgagaaat gcagcaagcc ctgtgcccga     1020

gtgtgctacg gcctaggcat ggagcacctg cgggaggcga gggcagtcac cagtgccaac     1080

atccaagaat ttgtcggctg caagaagatc tttgggagcc tggcgtttct gccagagagc     1140

tttgaggggg acccagcctc caacactgcc cccctgcagc ctgagcagct cagagtgttt     1200

gaggctctgg aggagattac aggttacctg tacatctcag cgtggccaga cagcttgcct     1260

aacctcagtg tcttccagaa cctcagagtg atccggggcc gagttctgca tgacggtgct     1320

tactcgctga cccttcaagg gctgggcatc agctggctgg ggctgcgctc gctgcgggag     1380

ctgggcagtg ggctggccct catccaccgc aactcccgcc tctgcttcgt acacacggtg     1440

ccctgggacc agctcttccg gaacccccac caggccctgc tccacagcgc caaccggcca     1500

gaggacgagt gcgcgggtga gggcctggcc tgctatccgc tgtgtgccca cgggcactgc     1560

tggggtccgg gacccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtatt gcaggggctt ccccgggagt atgtgaagga taggttctgt     1680

ctgccatgcc acccggagtg tcagccccag aatggctcag tgacctgctt gggctcggaa     1740

gctgaccagt gtgtggcctg tgcccactac aaggaccctc ctttctgtgt ggctcgctgc     1800

cccagtgggg tgaaacctga cctctccttc atgcccatct ggaagttcgc agatgaggag     1860

ggcacgtgcc agccatgccc catcaactgc acccactcct gtgcggacct ggacgagaag     1920

ggctgccccg ccgagcagag agccagccct gtgacgtcca tcattgctgc tgtggtgggc     1980

attctgctgg tcgtggttgt ggggctggtc cttggcatcc taatcaagcg aaggcggcag     2040

aagatccgga agtacacgat g                                               2061


<210>  44
<211>  1995
<212>  DNA
<213>  Felis catus

<400>  44
acccaagtgt gcaccggcac agacatgaag ctgcggctcc cagccagtcc cgagacccac       60

ctggacatgc tccgccacct ctaccagggc tgtcaagtgg tacagggcaa cctggagctc      120

acctacctgc atgccaatgc cagcctctcc ttcctgcagg atatccagga ggtgcaaggc      180

tatgtgctca ttgcccacaa ccaagtgaaa caggtcccac tgcagaggct acgaatcgtg      240

cgaggcaccc agctctttga ggacaactac gccctggccg tgctggacaa cggagaccca      300

ctggacagtg gcacccctgc tacaggggct gccctaggag ggctgcggga gctgcagctc      360

cgaagcctca cagagatcct gaagggaggg gtcctcattc agcggaaccc gcagctctgc      420

caccaggaca cgattctgtg gaaggacatc ttccacaaga acaaccagct ggccctcatg      480

ctgatagaca ccaaccgctc tcgggcctgc caaccctgtt ctccagcttg taaagactcc      540

cactgctggg gagcaagttc cggggactgt cagagcttga ctcgaactgt ctgtgctggc      600

ggctgtgccc gctgcaaggg cccgcagccc accgactgct gccacgagca atgtgctgct      660

ggctgcacgg gccccaagca ttctgactgc ctggcctgcc tccacttcaa ccacagtggc      720

atctgtgagc tgcactgccc agccctggtc acctacaaca cggacacctt cgaatccatg      780

cccaaccctg agggccgtta taccttcggt gccagctgtg tgactgcctg tccctacaac      840

tacctgtcta cggacgtggg atcctgcacc ctggtctgtc ccctgaacaa ccaagaggtg      900

acagctgagg atggaacaca gcggtgtgag aaatgcagca agccctgtgc ccgagtgtgc      960

tacggcctag gcatggagca cctgcgggag gcgagggcag tcaccagtgc caacatccaa     1020

gaatttgtcg gctgcaagaa gatctttggg agcctggcgt ttctgccaga gagctttgag     1080

ggggacccag cctccaacac tgcccccctg cagcctgagc agctcagagt gtttgaggct     1140

ctggaggaga ttacaggtta cctgtacatc tcagcgtggc cagacagctt gcctaacctc     1200

agtgtcttcc agaacctcag agtgatccgg ggccgagttc tgcatgacgg tgcttactcg     1260

ctgacccttc aagggctggg catcagctgg ctggggctgc gctcgctgcg ggagctgggc     1320

agtgggctgg ccctcatcca ccgcaactcc cgcctctgct tcgtacacac ggtgccctgg     1380

gaccagctct tccggaaccc ccaccaggcc ctgctccaca gcgccaaccg gccagaggac     1440

gagtgcgcgg gtgagggcct ggcctgctat ccgctgtgtg cccacgggca ctgctggggt     1500

ccgggaccca cccagtgtgt caactgcagc cagttccttc ggggccagga gtgcgtggag     1560

gaatgccgag tattgcaggg gcttccccgg gagtatgtga aggataggtt ctgtctgcca     1620

tgccacccgg agtgtcagcc ccagaatggc tcagtgacct gcttgggctc ggaagctgac     1680

cagtgtgtgg cctgtgccca ctacaaggac cctcctttct gtgtggctcg ctgccccagt     1740

ggggtgaaac ctgacctctc cttcatgccc atctggaagt tcgcagatga ggagggcacg     1800

tgccagccat gccccatcaa ctgcacccac tcctgtgcgg acctggacga gaagggctgc     1860

cccgccgagc agagagccag ccctgtgacg tccatcattg ctgctgtggt gggcattctg     1920

ctggtcgtgg ttgtggggct ggtccttggc atcctaatca agcgaaggcg gcagaagatc     1980

cggaagtaca cgatg                                                      1995


<210>  45
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 
        675                 680                 685         


<210>  46
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  46

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  


Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
            100                 105                 110         


Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
    130                 135                 140                 


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
145                 150                 155                 160 


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
                165                 170                 175     


Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
            180                 185                 190         


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             


Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             


Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
                325                 330                 335     


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         


Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             


Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile 
    370                 375                 380                 


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu 
385                 390                 395                 400 


Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn 
                405                 410                 415     


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
            420                 425                 430         


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His 
        435                 440                 445             


Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
    450                 455                 460                 


Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp 
465                 470                 475                 480 


Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly 
                485                 490                 495     


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
            500                 505                 510         


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
        515                 520                 525             


Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu 
    530                 535                 540                 


Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp 
545                 550                 555                 560 


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
                565                 570                 575     


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp 
            580                 585                 590         


Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys 
        595                 600                 605             


Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln 
    610                 615                 620                 


Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val Gly Ile Leu 
625                 630                 635                 640 


Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Lys Arg Arg 
                645                 650                 655     


Gln Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665 


<210>  47
<211>  688
<212>  PRT
<213>  Mus musculus

<400>  47

Met Glu Leu Ala Ala Trp Cys Arg Trp Gly Phe Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ser Pro Gly Ala Ala Gly Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Ala Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Met Leu Ile Ala His Asn Arg Val Lys His Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Lys Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Arg Asp Pro Leu Asp Asn Val Thr Thr 
        115                 120                 125             


Ala Ala Pro Gly Arg Thr Pro Glu Gly Leu Arg Glu Leu Gln Leu Arg 
    130                 135                 140                 


Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Arg Gly Asn Pro 
145                 150                 155                 160 


Gln Leu Cys Tyr Gln Asp Met Val Leu Trp Lys Asp Val Leu Arg Lys 
                165                 170                 175     


Asn Asn Gln Leu Ala Pro Val Asp Met Asp Thr Asn Arg Ser Arg Ala 
            180                 185                 190         


Cys Pro Pro Cys Ala Pro Thr Cys Lys Asp Asn His Cys Trp Gly Glu 
        195                 200                 205             


Ser Pro Glu Asp Cys Gln Ile Leu Thr Gly Thr Ile Cys Thr Ser Gly 
    210                 215                 220                 


Cys Ala Arg Cys Lys Gly Arg Leu Pro Thr Asp Cys Cys His Glu Gln 
225                 230                 235                 240 


Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys 
                245                 250                 255     


Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu 
            260                 265                 270         


Ile Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Leu Asn Pro Glu Gly 
        275                 280                 285             


Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Thr Cys Pro Tyr Asn Tyr 
    290                 295                 300                 


Leu Ser Thr Glu Val Gly Ser Cys Thr Leu Val Cys Pro Pro Asn Asn 
305                 310                 315                 320 


Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser 
                325                 330                 335     


Lys Pro Cys Ala Gly Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg 
            340                 345                 350         


Gly Ala Arg Ala Ile Thr Ser Asp Asn Ile Gln Glu Phe Ala Gly Cys 
        355                 360                 365             


Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly 
    370                 375                 380                 


Asn Pro Ser Ser Gly Val Ala Pro Leu Lys Pro Glu His Leu Gln Val 
385                 390                 395                 400 


Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp 
                405                 410                 415     


Pro Glu Ser Phe Gln Asp Leu Ser Val Phe Gln Asn Leu Arg Val Ile 
            420                 425                 430         


Arg Gly Arg Ile Leu His Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly 
        435                 440                 445             


Leu Gly Ile His Ser Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser 
    450                 455                 460                 


Gly Leu Ala Leu Ile His Arg Asn Thr His Leu Cys Phe Val Asn Thr 
465                 470                 475                 480 


Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His 
                485                 490                 495     


Ser Gly Asn Arg Pro Glu Glu Ala Cys Gly Leu Glu Gly Leu Val Cys 
            500                 505                 510         


Asn Ser Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln 
        515                 520                 525             


Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu 
    530                 535                 540                 


Cys Arg Val Trp Lys Gly Leu Pro Arg Glu Tyr Val Arg Gly Lys His 
545                 550                 555                 560 


Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Ser Ser Glu Thr 
                565                 570                 575     


Cys Tyr Gly Ser Glu Ala Asp Gln Cys Glu Ala Cys Ala His Tyr Lys 
            580                 585                 590         


Asp Ser Ser Ser Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp 
        595                 600                 605             


Leu Ser Tyr Met Pro Ile Trp Lys Tyr Pro Asp Glu Glu Gly Ile Cys 
    610                 615                 620                 


Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Glu 
625                 630                 635                 640 


Arg Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Val Thr Phe Ile Ile 
                645                 650                 655     


Ala Thr Val Val Gly Val Leu Leu Phe Leu Ile Ile Val Val Val Ile 
            660                 665                 670         


Gly Ile Leu Ile Lys Arg Arg Arg Gln Lys Ile Arg Lys Tyr Thr Met 
        675                 680                 685             


<210>  48
<211>  666
<212>  PRT
<213>  Mus musculus

<400>  48

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Ala Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Met Leu Ile 
    50                  55                  60                  


Ala His Asn Arg Val Lys His Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Lys Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Arg Asp Pro Leu Asp Asn Val Thr Thr Ala Ala Pro Gly Arg Thr 
            100                 105                 110         


Pro Glu Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu 
        115                 120                 125             


Lys Gly Gly Val Leu Ile Arg Gly Asn Pro Gln Leu Cys Tyr Gln Asp 
    130                 135                 140                 


Met Val Leu Trp Lys Asp Val Leu Arg Lys Asn Asn Gln Leu Ala Pro 
145                 150                 155                 160 


Val Asp Met Asp Thr Asn Arg Ser Arg Ala Cys Pro Pro Cys Ala Pro 
                165                 170                 175     


Thr Cys Lys Asp Asn His Cys Trp Gly Glu Ser Pro Glu Asp Cys Gln 
            180                 185                 190         


Ile Leu Thr Gly Thr Ile Cys Thr Ser Gly Cys Ala Arg Cys Lys Gly 
        195                 200                 205             


Arg Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr 
    210                 215                 220                 


Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser 
225                 230                 235                 240 


Gly Ile Cys Glu Leu His Cys Pro Ala Leu Ile Thr Tyr Asn Thr Asp 
                245                 250                 255     


Thr Phe Glu Ser Met Leu Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala 
            260                 265                 270         


Ser Cys Val Thr Thr Cys Pro Tyr Asn Tyr Leu Ser Thr Glu Val Gly 
        275                 280                 285             


Ser Cys Thr Leu Val Cys Pro Pro Asn Asn Gln Glu Val Thr Ala Glu 
    290                 295                 300                 


Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Gly Val 
305                 310                 315                 320 


Cys Tyr Gly Leu Gly Met Glu His Leu Arg Gly Ala Arg Ala Ile Thr 
                325                 330                 335     


Ser Asp Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser 
            340                 345                 350         


Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asn Pro Ser Ser Gly Val 
        355                 360                 365             


Ala Pro Leu Lys Pro Glu His Leu Gln Val Phe Glu Thr Leu Glu Glu 
    370                 375                 380                 


Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Glu Ser Phe Gln Asp 
385                 390                 395                 400 


Leu Ser Val Phe Gln Asn Leu Arg Val Ile Arg Gly Arg Ile Leu His 
                405                 410                 415     


Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile His Ser Leu 
            420                 425                 430         


Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His 
        435                 440                 445             


Arg Asn Thr His Leu Cys Phe Val Asn Thr Val Pro Trp Asp Gln Leu 
    450                 455                 460                 


Phe Arg Asn Pro His Gln Ala Leu Leu His Ser Gly Asn Arg Pro Glu 
465                 470                 475                 480 


Glu Ala Cys Gly Leu Glu Gly Leu Val Cys Asn Ser Leu Cys Ala Arg 
                485                 490                 495     


Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln 
            500                 505                 510         


Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Trp Lys Gly 
        515                 520                 525             


Leu Pro Arg Glu Tyr Val Arg Gly Lys His Cys Leu Pro Cys His Pro 
    530                 535                 540                 


Glu Cys Gln Pro Gln Asn Ser Ser Glu Thr Cys Tyr Gly Ser Glu Ala 
545                 550                 555                 560 


Asp Gln Cys Glu Ala Cys Ala His Tyr Lys Asp Ser Ser Ser Cys Val 
                565                 570                 575     


Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile 
            580                 585                 590         


Trp Lys Tyr Pro Asp Glu Glu Gly Ile Cys Gln Pro Cys Pro Ile Asn 
        595                 600                 605             


Cys Thr His Ser Cys Val Asp Leu Asp Glu Arg Gly Cys Pro Ala Glu 
    610                 615                 620                 


Gln Arg Ala Ser Pro Val Thr Phe Ile Ile Ala Thr Val Val Gly Val 
625                 630                 635                 640 


Leu Leu Phe Leu Ile Ile Val Val Val Ile Gly Ile Leu Ile Lys Arg 
                645                 650                 655     


Arg Arg Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665     


<210>  49
<211>  691
<212>  PRT
<213>  Rattus norvegicus

<400>  49

Met Ile Ile Met Glu Leu Ala Ala Trp Cys Arg Trp Gly Phe Leu Leu 
1               5                   10                  15      


Ala Leu Leu Pro Pro Gly Ile Ala Gly Thr Gln Val Cys Thr Gly Thr 
            20                  25                  30          


Asp Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met 
        35                  40                  45              


Leu Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu 
    50                  55                  60                  


Leu Thr Tyr Val Pro Ala Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile 
65                  70                  75                  80  


Gln Glu Val Gln Gly Tyr Met Leu Ile Ala His Asn Gln Val Lys Arg 
                85                  90                  95      


Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu 
            100                 105                 110         


Asp Lys Tyr Ala Leu Ala Val Leu Asp Asn Arg Asp Pro Gln Asp Asn 
        115                 120                 125             


Val Ala Ala Ser Thr Pro Gly Arg Thr Pro Glu Gly Leu Arg Glu Leu 
    130                 135                 140                 


Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Arg 
145                 150                 155                 160 


Gly Asn Pro Gln Leu Cys Tyr Gln Asp Met Val Leu Trp Lys Asp Val 
                165                 170                 175     


Phe Arg Lys Asn Asn Gln Leu Ala Pro Val Asp Ile Asp Thr Asn Arg 
            180                 185                 190         


Ser Arg Ala Cys Pro Pro Cys Ala Pro Ala Cys Lys Asp Asn His Cys 
        195                 200                 205             


Trp Gly Glu Ser Pro Glu Asp Cys Gln Ile Leu Thr Gly Thr Ile Cys 
    210                 215                 220                 


Thr Ser Gly Cys Ala Arg Cys Lys Gly Arg Leu Pro Thr Asp Cys Cys 
225                 230                 235                 240 


His Glu Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys 
                245                 250                 255     


Leu Ala Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys 
            260                 265                 270         


Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met His Asn 
        275                 280                 285             


Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Thr Cys Pro 
    290                 295                 300                 


Tyr Asn Tyr Leu Ser Thr Glu Val Gly Ser Cys Thr Leu Val Cys Pro 
305                 310                 315                 320 


Pro Asn Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu 
                325                 330                 335     


Lys Cys Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu 
            340                 345                 350         


His Leu Arg Gly Ala Arg Ala Ile Thr Ser Asp Asn Val Gln Glu Phe 
        355                 360                 365             


Asp Gly Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser 
    370                 375                 380                 


Phe Asp Gly Asp Pro Ser Ser Gly Ile Ala Pro Leu Arg Pro Glu Gln 
385                 390                 395                 400 


Leu Gln Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile 
                405                 410                 415     


Ser Ala Trp Pro Asp Ser Leu Arg Asp Leu Ser Val Phe Gln Asn Leu 
            420                 425                 430         


Arg Ile Ile Arg Gly Arg Ile Leu His Asp Gly Ala Tyr Ser Leu Thr 
        435                 440                 445             


Leu Gln Gly Leu Gly Ile His Ser Leu Gly Leu Arg Ser Leu Arg Glu 
    450                 455                 460                 


Leu Gly Ser Gly Leu Ala Leu Ile His Arg Asn Ala His Leu Cys Phe 
465                 470                 475                 480 


Val His Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala 
                485                 490                 495     


Leu Leu His Ser Gly Asn Arg Pro Glu Glu Asp Cys Gly Leu Glu Gly 
            500                 505                 510         


Leu Val Cys Asn Ser Leu Cys Ala His Gly His Cys Trp Gly Pro Gly 
        515                 520                 525             


Pro Thr Gln Cys Val Asn Cys Ser His Phe Leu Arg Gly Gln Glu Cys 
    530                 535                 540                 


Val Glu Glu Cys Arg Val Trp Lys Gly Leu Pro Arg Glu Tyr Val Ser 
545                 550                 555                 560 


Asp Lys Arg Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Ser 
                565                 570                 575     


Ser Glu Thr Cys Phe Gly Ser Glu Ala Asp Gln Cys Ala Ala Cys Ala 
            580                 585                 590         


His Tyr Lys Asp Ser Ser Ser Cys Val Ala Arg Cys Pro Ser Gly Val 
        595                 600                 605             


Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys Tyr Pro Asp Glu Glu 
    610                 615                 620                 


Gly Ile Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp 
625                 630                 635                 640 


Leu Asp Glu Arg Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Val Thr 
                645                 650                 655     


Phe Ile Ile Ala Thr Val Val Gly Val Leu Leu Phe Leu Ile Leu Val 
            660                 665                 670         


Val Val Val Gly Ile Leu Ile Lys Arg Arg Arg Gln Lys Ile Arg Lys 
        675                 680                 685             


Tyr Thr Met 
    690     


<210>  50
<211>  666
<212>  PRT
<213>  Rattus norvegicus

<400>  50

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Val Pro Ala Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Met Leu Ile 
    50                  55                  60                  


Ala His Asn Gln Val Lys Arg Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Lys Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Arg Asp Pro Gln Asp Asn Val Ala Ala Ser Thr Pro Gly Arg Thr 
            100                 105                 110         


Pro Glu Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu 
        115                 120                 125             


Lys Gly Gly Val Leu Ile Arg Gly Asn Pro Gln Leu Cys Tyr Gln Asp 
    130                 135                 140                 


Met Val Leu Trp Lys Asp Val Phe Arg Lys Asn Asn Gln Leu Ala Pro 
145                 150                 155                 160 


Val Asp Ile Asp Thr Asn Arg Ser Arg Ala Cys Pro Pro Cys Ala Pro 
                165                 170                 175     


Ala Cys Lys Asp Asn His Cys Trp Gly Glu Ser Pro Glu Asp Cys Gln 
            180                 185                 190         


Ile Leu Thr Gly Thr Ile Cys Thr Ser Gly Cys Ala Arg Cys Lys Gly 
        195                 200                 205             


Arg Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr 
    210                 215                 220                 


Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser 
225                 230                 235                 240 


Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp 
                245                 250                 255     


Thr Phe Glu Ser Met His Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala 
            260                 265                 270         


Ser Cys Val Thr Thr Cys Pro Tyr Asn Tyr Leu Ser Thr Glu Val Gly 
        275                 280                 285             


Ser Cys Thr Leu Val Cys Pro Pro Asn Asn Gln Glu Val Thr Ala Glu 
    290                 295                 300                 


Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val 
305                 310                 315                 320 


Cys Tyr Gly Leu Gly Met Glu His Leu Arg Gly Ala Arg Ala Ile Thr 
                325                 330                 335     


Ser Asp Asn Val Gln Glu Phe Asp Gly Cys Lys Lys Ile Phe Gly Ser 
            340                 345                 350         


Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ser Ser Gly Ile 
        355                 360                 365             


Ala Pro Leu Arg Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu 
    370                 375                 380                 


Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Arg Asp 
385                 390                 395                 400 


Leu Ser Val Phe Gln Asn Leu Arg Ile Ile Arg Gly Arg Ile Leu His 
                405                 410                 415     


Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile His Ser Leu 
            420                 425                 430         


Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His 
        435                 440                 445             


Arg Asn Ala His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu 
    450                 455                 460                 


Phe Arg Asn Pro His Gln Ala Leu Leu His Ser Gly Asn Arg Pro Glu 
465                 470                 475                 480 


Glu Asp Cys Gly Leu Glu Gly Leu Val Cys Asn Ser Leu Cys Ala His 
                485                 490                 495     


Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser His 
            500                 505                 510         


Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Trp Lys Gly 
        515                 520                 525             


Leu Pro Arg Glu Tyr Val Ser Asp Lys Arg Cys Leu Pro Cys His Pro 
    530                 535                 540                 


Glu Cys Gln Pro Gln Asn Ser Ser Glu Thr Cys Phe Gly Ser Glu Ala 
545                 550                 555                 560 


Asp Gln Cys Ala Ala Cys Ala His Tyr Lys Asp Ser Ser Ser Cys Val 
                565                 570                 575     


Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile 
            580                 585                 590         


Trp Lys Tyr Pro Asp Glu Glu Gly Ile Cys Gln Pro Cys Pro Ile Asn 
        595                 600                 605             


Cys Thr His Ser Cys Val Asp Leu Asp Glu Arg Gly Cys Pro Ala Glu 
    610                 615                 620                 


Gln Arg Ala Ser Pro Val Thr Phe Ile Ile Ala Thr Val Val Gly Val 
625                 630                 635                 640 


Leu Leu Phe Leu Ile Leu Val Val Val Val Gly Ile Leu Ile Lys Arg 
                645                 650                 655     


Arg Arg Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665     


<210>  51
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric human-rat E2Neu (HER2)

<400>  51

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Glu Phe Ala Pro Leu Arg Pro Glu Gln Leu 
385                 390                 395                 400 


Gln Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser 
                405                 410                 415     


Ala Trp Pro Asp Ser Leu Arg Asp Leu Ser Val Phe Gln Asn Leu Arg 
            420                 425                 430         


Ile Ile Arg Gly Arg Ile Leu His Asp Gly Ala Tyr Ser Leu Thr Leu 
        435                 440                 445             


Gln Gly Leu Gly Ile His Ser Leu Gly Leu Arg Ser Leu Arg Glu Leu 
    450                 455                 460                 


Gly Ser Gly Leu Ala Leu Ile His Arg Asn Ala His Leu Cys Phe Val 
465                 470                 475                 480 


His Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu 
                485                 490                 495     


Leu His Ser Gly Asn Arg Pro Glu Glu Asp Cys Gly Leu Glu Gly Leu 
            500                 505                 510         


Val Cys Asn Ser Leu Cys Ala His Gly His Cys Trp Gly Pro Gly Pro 
        515                 520                 525             


Thr Gln Cys Val Asn Cys Ser His Phe Leu Arg Gly Gln Glu Cys Val 
    530                 535                 540                 


Glu Glu Cys Arg Val Trp Lys Gly Leu Pro Arg Glu Tyr Val Ser Asp 
545                 550                 555                 560 


Lys Arg Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Ser Ser 
                565                 570                 575     


Glu Thr Cys Phe Gly Ser Glu Ala Asp Gln Cys Ala Ala Cys Ala His 
            580                 585                 590         


Tyr Lys Asp Ser Ser Ser Cys Val Ala Arg Cys Pro Ser Gly Val Lys 
        595                 600                 605             


Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys Tyr Pro Asp Glu Glu Gly 
    610                 615                 620                 


Ile Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu 
625                 630                 635                 640 


Asp Glu Arg Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Val Thr Phe 
                645                 650                 655     


Ile Ile Ala Thr Val Val Gly Val Leu Leu Phe Leu Ile Leu Val Val 
            660                 665                 670         


Val Val Gly Ile Leu Ile Lys Arg Arg Arg Gln Lys Ile Arg Lys Tyr 
        675                 680                 685             


Thr Met 
    690 


<210>  52
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric human-rat E2Neu (HER2)

<400>  52

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  


Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
            100                 105                 110         


Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
    130                 135                 140                 


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
145                 150                 155                 160 


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
                165                 170                 175     


Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
            180                 185                 190         


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             


Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             


Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
                325                 330                 335     


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         


Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             


Glu Phe Ala Pro Leu Arg Pro Glu Gln Leu Gln Val Phe Glu Thr Leu 
    370                 375                 380                 


Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu 
385                 390                 395                 400 


Arg Asp Leu Ser Val Phe Gln Asn Leu Arg Ile Ile Arg Gly Arg Ile 
                405                 410                 415     


Leu His Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile His 
            420                 425                 430         


Ser Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu 
        435                 440                 445             


Ile His Arg Asn Ala His Leu Cys Phe Val His Thr Val Pro Trp Asp 
    450                 455                 460                 


Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Ser Gly Asn Arg 
465                 470                 475                 480 


Pro Glu Glu Asp Cys Gly Leu Glu Gly Leu Val Cys Asn Ser Leu Cys 
                485                 490                 495     


Ala His Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys 
            500                 505                 510         


Ser His Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Trp 
        515                 520                 525             


Lys Gly Leu Pro Arg Glu Tyr Val Ser Asp Lys Arg Cys Leu Pro Cys 
    530                 535                 540                 


His Pro Glu Cys Gln Pro Gln Asn Ser Ser Glu Thr Cys Phe Gly Ser 
545                 550                 555                 560 


Glu Ala Asp Gln Cys Ala Ala Cys Ala His Tyr Lys Asp Ser Ser Ser 
                565                 570                 575     


Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met 
            580                 585                 590         


Pro Ile Trp Lys Tyr Pro Asp Glu Glu Gly Ile Cys Gln Pro Cys Pro 
        595                 600                 605             


Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Glu Arg Gly Cys Pro 
    610                 615                 620                 


Ala Glu Gln Arg Ala Ser Pro Val Thr Phe Ile Ile Ala Thr Val Val 
625                 630                 635                 640 


Gly Val Leu Leu Phe Leu Ile Leu Val Val Val Val Gly Ile Leu Ile 
                645                 650                 655     


Lys Arg Arg Arg Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665             


<210>  53
<211>  2064
<212>  DNA
<213>  Homo sapiens

<400>  53
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct ccaagtgttt     1200

gagactctgg aagagatcac aggttaccta tacatctcag catggccgga cagcctgcct     1260

gacctcagcg tcttccagaa cctgcaagta atccggggac gaattctgca caatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc actgagggaa     1380

ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt gcacacggtg     1440

ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc caaccggcca     1500

gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg agggcactgc     1560

tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc caggcactgt     1680

ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag     1740

gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc     1800

cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag     1860

ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct ggatgacaag     1920

ggctgccccg ccgagcagag agccagccct ctgacgtcca tcatctctgc ggtggttggc     1980

attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatcaagcg acggcagcag     2040

aagatccgga agtacacgat gtga                                            2064


<210>  54
<211>  1998
<212>  DNA
<213>  Homo sapiens

<400>  54
acccaagtgt gcaccggcac agacatgaag ctgcggctcc ctgccagtcc cgagacccac       60

ctggacatgc tccgccacct ctaccagggc tgccaggtgg tgcagggaaa cctggaactc      120

acctacctgc ccaccaatgc cagcctgtcc ttcctgcagg atatccagga ggtgcagggc      180

tacgtgctca tcgctcacaa ccaagtgagg caggtcccac tgcagaggct gcggattgtg      240

cgaggcaccc agctctttga ggacaactat gccctggccg tgctagacaa tggagacccg      300

ctgaacaata ccacccctgt cacaggggcc tccccaggag gcctgcggga gctgcagctt      360

cgaagcctca cagagatctt gaaaggaggg gtcttgatcc agcggaaccc ccagctctgc      420

taccaggaca cgattttgtg gaaggacatc ttccacaaga acaaccagct ggctctcaca      480

ctgatagaca ccaaccgctc tcgggcctgc cacccctgtt ctccgatgtg taagggctcc      540

cgctgctggg gagagagttc tgaggattgt cagagcctga cgcgcactgt ctgtgccggt      600

ggctgtgccc gctgcaaggg gccactgccc actgactgct gccatgagca gtgtgctgcc      660

ggctgcacgg gccccaagca ctctgactgc ctggcctgcc tccacttcaa ccacagtggc      720

atctgtgagc tgcactgccc agccctggtc acctacaaca cagacacgtt tgagtccatg      780

cccaatcccg agggccggta tacattcggc gccagctgtg tgactgcctg tccctacaac      840

tacctttcta cggacgtggg atcctgcacc ctcgtctgcc ccctgcacaa ccaagaggtg      900

acagcagagg atggaacaca gcggtgtgag aagtgcagca agccctgtgc ccgagtgtgc      960

tatggtctgg gcatggagca cttgcgagag gtgagggcag ttaccagtgc caatatccag     1020

gagtttgctg gctgcaagaa gatctttggg agcctggcat ttctgccgga gagctttgat     1080

ggggacccag cctccaacac tgccccgctc cagccagagc agctccaagt gtttgagact     1140

ctggaagaga tcacaggtta cctatacatc tcagcatggc cggacagcct gcctgacctc     1200

agcgtcttcc agaacctgca agtaatccgg ggacgaattc tgcacaatgg cgcctactcg     1260

ctgaccctgc aagggctggg catcagctgg ctggggctgc gctcactgag ggaactgggc     1320

agtggactgg ccctcatcca ccataacacc cacctctgct tcgtgcacac ggtgccctgg     1380

gaccagctct ttcggaaccc gcaccaagct ctgctccaca ctgccaaccg gccagaggac     1440

gagtgtgtgg gcgagggcct ggcctgccac cagctgtgcg cccgagggca ctgctggggt     1500

ccagggccca cccagtgtgt caactgcagc cagttccttc ggggccagga gtgcgtggag     1560

gaatgccgag tactgcaggg gctccccagg gagtatgtga atgccaggca ctgtttgccg     1620

tgccaccctg agtgtcagcc ccagaatggc tcagtgacct gttttggacc ggaggctgac     1680

cagtgtgtgg cctgtgccca ctataaggac cctcccttct gcgtggcccg ctgccccagc     1740

ggtgtgaaac ctgacctctc ctacatgccc atctggaagt ttccagatga ggagggcgca     1800

tgccagcctt gccccatcaa ctgcacccac tcctgtgtgg acctggatga caagggctgc     1860

cccgccgagc agagagccag ccctctgacg tccatcatct ctgcggtggt tggcattctg     1920

ctggtcgtgg tcttgggggt ggtctttggg atcctcatca agcgacggca gcagaagatc     1980

cggaagtaca cgatgtga                                                   1998


<210>  55
<211>  2064
<212>  DNA
<213>  Mus musculus

<400>  55
atggagctgg cggcctggtg ccgttggggg ttcctcctcg ccctcctgtc ccccggagcc       60

gcgggtaccc aagtgtgtac cggtaccgac atgaagttgc gactccctgc cagtcctgag      120

acccacctgg acatgcttcg ccacctctac cagggctgtc aggtggtgca gggcaatttg      180

gagcttacct acctgcccgc caatgccagc ctctcattcc tgcaggacat ccaggaagtc      240

cagggataca tgctcatcgc tcacaaccga gtgaaacacg tcccactgca gaggttgcgc      300

atcgtgagag ggactcagct ctttgaggac aagtatgccc tggctgtgct agacaaccga      360

gaccctttgg acaacgtcac caccgccgcc ccaggcagaa ccccagaagg gctgcgggag      420

ctgcagcttc gaagtctcac agagatcttg aagggaggag ttttgatccg tgggaaccct      480

cagctctgct accaggacat ggttttgtgg aaggatgtcc tccgtaagaa taaccagctg      540

gctcctgtcg acatggacac caatcgttcc cgggcctgtc caccttgtgc cccaacctgc      600

aaagacaatc actgttgggg tgagagtcct gaagactgtc agatcttgac tggcaccatc      660

tgtactagtg gctgtgcccg gtgcaagggc cggctgccca ctgactgttg ccatgagcag      720

tgtgctgcag gctgcacggg tcccaagcat tctgactgcc tggcctgcct ccacttcaat      780

catagtggta tctgtgagct gcactgcccg gccctcatca cctacaacac agacaccttc      840

gagtccatgc tcaaccctga gggtcgctac acctttggtg ccagctgtgt gaccacctgc      900

ccctacaact acctctccac ggaagtggga tcctgcactc tggtctgtcc cccgaacaac      960

caagaggtca cagctgagga cggaacacag cggtgtgaga aatgcagcaa gccctgtgct     1020

ggagtatgct atggtctggg catggagcac ctccgagggg cgagggccat caccagtgac     1080

aatatccagg agtttgctgg ctgcaagaag atctttggga gcctggcatt tttgccggag     1140

agctttgatg ggaacccctc ctccggcgtt gccccactga agccagagca tctccaagtg     1200

ttcgaaaccc tggaggagat cacaggttac ctatacattt cagcatggcc agagagcttc     1260

caagacctca gtgtcttcca gaaccttcgg gtcattcggg gacggattct ccatgatggt     1320

gcttactcat tgacgttgca aggcctgggg attcactcac tggggctacg ctcactgcgg     1380

gagctgggca gtggattggc tctcattcac cgcaacaccc atctctgctt tgtaaacact     1440

gtaccttggg accagctctt ccggaacccg caccaggccc tactccacag tgggaaccgg     1500

ccagaagagg catgtggtct tgagggcttg gtctgtaact cactgtgtgc ccgtgggcac     1560

tgctgggggc cagggcccac ccagtgtgtc aactgcagtc agttcctccg gggccaggag     1620

tgtgtggagg agtgccgagt atggaagggg ctccccaggg agtatgtgag gggcaagcac     1680

tgtctgccat gccaccccga gtgtcagcct caaaacagct cggagacctg ctatggatcg     1740

gaggctgacc agtgtgaggc ttgtgcccac tacaaggact catcttcctg tgtggctcgc     1800

tgccccagtg gtgtgaagcc agacctctcc tacatgccta tctggaagta cccggatgag     1860

gagggcatat gtcagccatg ccccatcaac tgcacccact catgtgtgga cctggacgaa     1920

cgaggctgcc cagcagagca gagagccagc ccagtgacat tcatcattgc aactgtggtg     1980

ggcgtcctgt tgttcctgat catagtggtg gtcattggaa tcctaatcaa acgaaggcga     2040

cagaagatcc ggaagtatac catg                                            2064


<210>  56
<211>  1998
<212>  DNA
<213>  Mus musculus

<400>  56
acccaagtgt gtaccggtac cgacatgaag ttgcgactcc ctgccagtcc tgagacccac       60

ctggacatgc ttcgccacct ctaccagggc tgtcaggtgg tgcagggcaa tttggagctt      120

acctacctgc ccgccaatgc cagcctctca ttcctgcagg acatccagga agtccaggga      180

tacatgctca tcgctcacaa ccgagtgaaa cacgtcccac tgcagaggtt gcgcatcgtg      240

agagggactc agctctttga ggacaagtat gccctggctg tgctagacaa ccgagaccct      300

ttggacaacg tcaccaccgc cgccccaggc agaaccccag aagggctgcg ggagctgcag      360

cttcgaagtc tcacagagat cttgaaggga ggagttttga tccgtgggaa ccctcagctc      420

tgctaccagg acatggtttt gtggaaggat gtcctccgta agaataacca gctggctcct      480

gtcgacatgg acaccaatcg ttcccgggcc tgtccacctt gtgccccaac ctgcaaagac      540

aatcactgtt ggggtgagag tcctgaagac tgtcagatct tgactggcac catctgtact      600

agtggctgtg cccggtgcaa gggccggctg cccactgact gttgccatga gcagtgtgct      660

gcaggctgca cgggtcccaa gcattctgac tgcctggcct gcctccactt caatcatagt      720

ggtatctgtg agctgcactg cccggccctc atcacctaca acacagacac cttcgagtcc      780

atgctcaacc ctgagggtcg ctacaccttt ggtgccagct gtgtgaccac ctgcccctac      840

aactacctct ccacggaagt gggatcctgc actctggtct gtcccccgaa caaccaagag      900

gtcacagctg aggacggaac acagcggtgt gagaaatgca gcaagccctg tgctggagta      960

tgctatggtc tgggcatgga gcacctccga ggggcgaggg ccatcaccag tgacaatatc     1020

caggagtttg ctggctgcaa gaagatcttt gggagcctgg catttttgcc ggagagcttt     1080

gatgggaacc cctcctccgg cgttgcccca ctgaagccag agcatctcca agtgttcgaa     1140

accctggagg agatcacagg ttacctatac atttcagcat ggccagagag cttccaagac     1200

ctcagtgtct tccagaacct tcgggtcatt cggggacgga ttctccatga tggtgcttac     1260

tcattgacgt tgcaaggcct ggggattcac tcactggggc tacgctcact gcgggagctg     1320

ggcagtggat tggctctcat tcaccgcaac acccatctct gctttgtaaa cactgtacct     1380

tgggaccagc tcttccggaa cccgcaccag gccctactcc acagtgggaa ccggccagaa     1440

gaggcatgtg gtcttgaggg cttggtctgt aactcactgt gtgcccgtgg gcactgctgg     1500

gggccagggc ccacccagtg tgtcaactgc agtcagttcc tccggggcca ggagtgtgtg     1560

gaggagtgcc gagtatggaa ggggctcccc agggagtatg tgaggggcaa gcactgtctg     1620

ccatgccacc ccgagtgtca gcctcaaaac agctcggaga cctgctatgg atcggaggct     1680

gaccagtgtg aggcttgtgc ccactacaag gactcatctt cctgtgtggc tcgctgcccc     1740

agtggtgtga agccagacct ctcctacatg cctatctgga agtacccgga tgaggagggc     1800

atatgtcagc catgccccat caactgcacc cactcatgtg tggacctgga cgaacgaggc     1860

tgcccagcag agcagagagc cagcccagtg acattcatca ttgcaactgt ggtgggcgtc     1920

ctgttgttcc tgatcatagt ggtggtcatt ggaatcctaa tcaaacgaag gcgacagaag     1980

atccggaagt ataccatg                                                   1998


<210>  57
<211>  2073
<212>  DNA
<213>  Rattus norvegicus

<400>  57
atgatcatca tggagctggc ggcctggtgc cgctgggggt tcctcctcgc cctcctgccc       60

cccggaatcg cgggcaccca agtgtgtacc ggcacagaca tgaagttgcg gctccctgcc      120

agtcctgaga cccacctgga catgctccgc cacctgtacc agggctgtca ggtagtgcag      180

ggcaacttgg agcttaccta cgtgcctgcc aatgccagcc tctcattcct gcaggacatc      240

caggaagttc agggttacat gctcatcgct cacaaccagg tgaagcgcgt cccactgcaa      300

aggctgcgca tcgtgagagg gacccagctc tttgaggaca agtatgccct ggctgtgcta      360

gacaaccgag atcctcagga caatgtcgcc gcctccaccc caggcagaac cccagagggg      420

ctgcgggagc tgcagcttcg aagtctcaca gagatcctga agggaggagt tttgatccgt      480

gggaaccctc agctctgcta ccaggacatg gttttgtgga aggacgtctt ccgcaagaat      540

aaccaactgg ctcctgtcga tatagacacc aatcgttccc gggcctgtcc accttgtgcc      600

cccgcctgca aagacaatca ctgttggggt gagagtccgg aagactgtca gatcttgact      660

ggcaccatct gtaccagtgg ttgtgcccgg tgcaagggcc ggctgcccac tgactgctgc      720

catgagcagt gtgccgcagg ctgcacgggc cccaagcatt ctgactgcct ggcctgcctc      780

cacttcaatc atagtggtat ctgtgagctg cactgcccag ccctcgtcac ctacaacaca      840

gacacctttg agtccatgca caaccctgag ggtcgctaca cctttggtgc cagctgcgtg      900

accacctgcc cctacaacta cctgtctacg gaagtgggat cctgcactct ggtgtgtccc      960

ccgaataacc aagaggtcac agctgaggac ggaacacagc gttgtgagaa atgcagcaag     1020

ccctgtgctc gagtgtgcta tggtctgggc atggagcacc ttcgaggggc gagggccatc     1080

accagtgaca atgtccagga gtttgatggc tgcaagaaga tctttgggag cctggcattt     1140

ttgccggaga gctttgatgg ggacccctcc tccggcattg ctccgctgag gcctgagcag     1200

ctccaagtgt tcgaaaccct ggaggagatc acaggttacc tgtacatctc agcatggcca     1260

gacagtctcc gtgacctcag tgtcttccag aaccttcgaa tcattcgggg acggattctc     1320

cacgatggcg cgtactcatt gacactgcaa ggcctgggga tccactcgct ggggctgcgc     1380

tcactgcggg agctgggcag tggattggct ctgattcacc gcaacgccca tctctgcttt     1440

gtacacactg taccttggga ccagctcttc cggaacccac atcaggccct gctccacagt     1500

gggaaccggc cggaagagga ttgtggtctc gagggcttgg tctgtaactc actgtgtgcc     1560

cacgggcact gctgggggcc agggcccacc cagtgtgtca actgcagtca tttccttcgg     1620

ggccaggagt gtgtggagga gtgccgagta tggaaggggc tcccccggga gtatgtgagt     1680

gacaagcgct gtctgccgtg tcaccccgag tgtcagcctc aaaacagctc agagacctgc     1740

tttggatcgg aggctgatca gtgtgcagcc tgcgcccact acaaggactc gtcctcctgt     1800

gtggctcgct gccccagtgg tgtgaaaccg gacctctcct acatgcccat ctggaagtac     1860

ccggatgagg agggcatatg ccagccgtgc cccatcaact gcacccactc ctgtgtggat     1920

ctggatgaac gaggctgccc agcagagcag agagccagcc cggtgacatt catcattgca     1980

actgtagtgg gcgtcctgct gttcctgatc ttagtggtgg tcgttggaat cctaatcaaa     2040

cgaaggagac agaagatccg gaagtatacg atg                                  2073


<210>  58
<211>  1998
<212>  DNA
<213>  Rattus norvegicus

<400>  58
acccaagtgt gtaccggcac agacatgaag ttgcggctcc ctgccagtcc tgagacccac       60

ctggacatgc tccgccacct gtaccagggc tgtcaggtag tgcagggcaa cttggagctt      120

acctacgtgc ctgccaatgc cagcctctca ttcctgcagg acatccagga agttcagggt      180

tacatgctca tcgctcacaa ccaggtgaag cgcgtcccac tgcaaaggct gcgcatcgtg      240

agagggaccc agctctttga ggacaagtat gccctggctg tgctagacaa ccgagatcct      300

caggacaatg tcgccgcctc caccccaggc agaaccccag aggggctgcg ggagctgcag      360

cttcgaagtc tcacagagat cctgaaggga ggagttttga tccgtgggaa ccctcagctc      420

tgctaccagg acatggtttt gtggaaggac gtcttccgca agaataacca actggctcct      480

gtcgatatag acaccaatcg ttcccgggcc tgtccacctt gtgcccccgc ctgcaaagac      540

aatcactgtt ggggtgagag tccggaagac tgtcagatct tgactggcac catctgtacc      600

agtggttgtg cccggtgcaa gggccggctg cccactgact gctgccatga gcagtgtgcc      660

gcaggctgca cgggccccaa gcattctgac tgcctggcct gcctccactt caatcatagt      720

ggtatctgtg agctgcactg cccagccctc gtcacctaca acacagacac ctttgagtcc      780

atgcacaacc ctgagggtcg ctacaccttt ggtgccagct gcgtgaccac ctgcccctac      840

aactacctgt ctacggaagt gggatcctgc actctggtgt gtcccccgaa taaccaagag      900

gtcacagctg aggacggaac acagcgttgt gagaaatgca gcaagccctg tgctcgagtg      960

tgctatggtc tgggcatgga gcaccttcga ggggcgaggg ccatcaccag tgacaatgtc     1020

caggagtttg atggctgcaa gaagatcttt gggagcctgg catttttgcc ggagagcttt     1080

gatggggacc cctcctccgg cattgctccg ctgaggcctg agcagctcca agtgttcgaa     1140

accctggagg agatcacagg ttacctgtac atctcagcat ggccagacag tctccgtgac     1200

ctcagtgtct tccagaacct tcgaatcatt cggggacgga ttctccacga tggcgcgtac     1260

tcattgacac tgcaaggcct ggggatccac tcgctggggc tgcgctcact gcgggagctg     1320

ggcagtggat tggctctgat tcaccgcaac gcccatctct gctttgtaca cactgtacct     1380

tgggaccagc tcttccggaa cccacatcag gccctgctcc acagtgggaa ccggccggaa     1440

gaggattgtg gtctcgaggg cttggtctgt aactcactgt gtgcccacgg gcactgctgg     1500

gggccagggc ccacccagtg tgtcaactgc agtcatttcc ttcggggcca ggagtgtgtg     1560

gaggagtgcc gagtatggaa ggggctcccc cgggagtatg tgagtgacaa gcgctgtctg     1620

ccgtgtcacc ccgagtgtca gcctcaaaac agctcagaga cctgctttgg atcggaggct     1680

gatcagtgtg cagcctgcgc ccactacaag gactcgtcct cctgtgtggc tcgctgcccc     1740

agtggtgtga aaccggacct ctcctacatg cccatctgga agtacccgga tgaggagggc     1800

atatgccagc cgtgccccat caactgcacc cactcctgtg tggatctgga tgaacgaggc     1860

tgcccagcag agcagagagc cagcccggtg acattcatca ttgcaactgt agtgggcgtc     1920

ctgctgttcc tgatcttagt ggtggtcgtt ggaatcctaa tcaaacgaag gagacagaag     1980

atccggaagt atacgatg                                                   1998


<210>  59
<211>  2070
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric human-rat E2Neu (HER2)

<400>  59
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc gaattcgctc cgctgaggcc tgagcagctc     1200

caagtgttcg aaaccctgga ggagatcaca ggttacctgt acatctcagc atggccagac     1260

agtctccgtg acctcagtgt cttccagaac cttcgaatca ttcggggacg gattctccac     1320

gatggcgcgt actcattgac actgcaaggc ctggggatcc actcgctggg gctgcgctca     1380

ctgcgggagc tgggcagtgg attggctctg attcaccgca acgcccatct ctgctttgta     1440

cacactgtac cttgggacca gctcttccgg aacccacatc aggccctgct ccacagtggg     1500

aaccggccgg aagaggattg tggtctcgag ggcttggtct gtaactcact gtgtgcccac     1560

gggcactgct gggggccagg gcccacccag tgtgtcaact gcagtcattt ccttcggggc     1620

caggagtgtg tggaggagtg ccgagtatgg aaggggctcc cccgggagta tgtgagtgac     1680

aagcgctgtc tgccgtgtca ccccgagtgt cagcctcaaa acagctcaga gacctgcttt     1740

ggatcggagg ctgatcagtg tgcagcctgc gcccactaca aggactcgtc ctcctgtgtg     1800

gctcgctgcc ccagtggtgt gaaaccggac ctctcctaca tgcccatctg gaagtacccg     1860

gatgaggagg gcatatgcca gccgtgcccc atcaactgca cccactcctg tgtggatctg     1920

gatgaacgag gctgcccagc agagcagaga gccagcccgg tgacattcat cattgcaact     1980

gtagtgggcg tcctgctgtt cctgatctta gtggtggtcg ttggaatcct aatcaaacga     2040

aggagacaga agatccggaa gtatacgatg                                      2070


<210>  60
<211>  2004
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric human-rat E2Neu (HER2)

<400>  60
acccaagtgt gcaccggcac agacatgaag ctgcggctcc ctgccagtcc cgagacccac       60

ctggacatgc tccgccacct ctaccagggc tgccaggtgg tgcagggaaa cctggaactc      120

acctacctgc ccaccaatgc cagcctgtcc ttcctgcagg atatccagga ggtgcagggc      180

tacgtgctca tcgctcacaa ccaagtgagg caggtcccac tgcagaggct gcggattgtg      240

cgaggcaccc agctctttga ggacaactat gccctggccg tgctagacaa tggagacccg      300

ctgaacaata ccacccctgt cacaggggcc tccccaggag gcctgcggga gctgcagctt      360

cgaagcctca cagagatctt gaaaggaggg gtcttgatcc agcggaaccc ccagctctgc      420

taccaggaca cgattttgtg gaaggacatc ttccacaaga acaaccagct ggctctcaca      480

ctgatagaca ccaaccgctc tcgggcctgc cacccctgtt ctccgatgtg taagggctcc      540

cgctgctggg gagagagttc tgaggattgt cagagcctga cgcgcactgt ctgtgccggt      600

ggctgtgccc gctgcaaggg gccactgccc actgactgct gccatgagca gtgtgctgcc      660

ggctgcacgg gccccaagca ctctgactgc ctggcctgcc tccacttcaa ccacagtggc      720

atctgtgagc tgcactgccc agccctggtc acctacaaca cagacacgtt tgagtccatg      780

cccaatcccg agggccggta tacattcggc gccagctgtg tgactgcctg tccctacaac      840

tacctttcta cggacgtggg atcctgcacc ctcgtctgcc ccctgcacaa ccaagaggtg      900

acagcagagg atggaacaca gcggtgtgag aagtgcagca agccctgtgc ccgagtgtgc      960

tatggtctgg gcatggagca cttgcgagag gtgagggcag ttaccagtgc caatatccag     1020

gagtttgctg gctgcaagaa gatctttggg agcctggcat ttctgccgga gagctttgat     1080

ggggacccag cctccaacac tgccgaattc gctccgctga ggcctgagca gctccaagtg     1140

ttcgaaaccc tggaggagat cacaggttac ctgtacatct cagcatggcc agacagtctc     1200

cgtgacctca gtgtcttcca gaaccttcga atcattcggg gacggattct ccacgatggc     1260

gcgtactcat tgacactgca aggcctgggg atccactcgc tggggctgcg ctcactgcgg     1320

gagctgggca gtggattggc tctgattcac cgcaacgccc atctctgctt tgtacacact     1380

gtaccttggg accagctctt ccggaaccca catcaggccc tgctccacag tgggaaccgg     1440

ccggaagagg attgtggtct cgagggcttg gtctgtaact cactgtgtgc ccacgggcac     1500

tgctgggggc cagggcccac ccagtgtgtc aactgcagtc atttccttcg gggccaggag     1560

tgtgtggagg agtgccgagt atggaagggg ctcccccggg agtatgtgag tgacaagcgc     1620

tgtctgccgt gtcaccccga gtgtcagcct caaaacagct cagagacctg ctttggatcg     1680

gaggctgatc agtgtgcagc ctgcgcccac tacaaggact cgtcctcctg tgtggctcgc     1740

tgccccagtg gtgtgaaacc ggacctctcc tacatgccca tctggaagta cccggatgag     1800

gagggcatat gccagccgtg ccccatcaac tgcacccact cctgtgtgga tctggatgaa     1860

cgaggctgcc cagcagagca gagagccagc ccggtgacat tcatcattgc aactgtagtg     1920

ggcgtcctgc tgttcctgat cttagtggtg gtcgttggaa tcctaatcaa acgaaggaga     1980

cagaagatcc ggaagtatac gatg                                            2004


<210>  61
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FCA733 forward primer

<400>  61
aggctcctct aggtttactg d                                                 21


<210>  62
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FCA733 reverse primer

<400>  62
ccaccgataa gtgaaatggt atgg                                              24


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FCA749 forward primer

<400>  63
gggtgatgtg acctcttgta g                                                 21


<210>  64
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FCA749 reverse primer

<400>  64
ggacagaggc tccttaaaca g                                                 21


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MACROD2 foward primer

<400>  65
tcttccctcc tccgtgtatg                                                   20


<210>  66
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MACROD2 reverse primer

<400>  66
agacgctcaa tcaactgagc catc                                              24


<210>  67
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mtCR forward primer

<400>  67
tcttctcgct ccgggcccat ttc                                               23


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mtCR reverse primer

<400>  68
agtctggcga ctcatctagg                                                   20


<210>  69
<211>  885
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein feHER2ecd-hFc

<400>  69

Met Glu Leu Ala Ala Trp Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Ser Gly Ala Thr Gly Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu His Ala Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Lys Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asp Ser Gly Thr Pro 
        115                 120                 125             


Ala Thr Gly Ala Ala Leu Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys His Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Met Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


Gln Pro Cys Ser Pro Ala Cys Lys Asp Ser His Cys Trp Gly Ala Ser 
        195                 200                 205             


Ser Gly Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Gln Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu Asn Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Ala Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Val Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Glu Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Arg Val Phe 
385                 390                 395                 400 


Glu Ala Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asn Leu Ser Val Phe Gln Asn Leu Arg Val Ile Arg 
            420                 425                 430         


Gly Arg Val Leu His Asp Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His Arg Asn Ser Arg Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Ser 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Ala Gly Glu Gly Leu Ala Cys Tyr 
            500                 505                 510         


Pro Leu Cys Ala His Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Lys Asp Arg Phe Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Leu Gly Ser Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Phe Met Pro Ile Trp Lys Phe Ala Asp Glu Glu Gly Thr Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Ala Asp Leu Asp Glu Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Val Thr Ser Glu Pro Lys 
                645                 650                 655     


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            660                 665                 670         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        675                 680                 685             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    690                 695                 700                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
705                 710                 715                 720 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                725                 730                 735     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            740                 745                 750         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        755                 760                 765             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    770                 775                 780                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
785                 790                 795                 800 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                805                 810                 815     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            820                 825                 830         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        835                 840                 845             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    850                 855                 860                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
865                 870                 875                 880 


Leu Ser Pro Gly Lys 
                885 


<210>  70
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Feline HER2 ECTM (prefeHER2) FORWARD PRIMER

<400>  70
attactacaa gcttgagacc atggagctgg cggcctggt                              39


<210>  71
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Feline HER2 ECTM (prefeHER2) Reverse PRIMER

<400>  71
tactaatcta gatcacatcg tgtacttccg gatcttctg                              39


<210>  72
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Feline HER2 ECD-Fc ECD FORWARD PRIMER

<400>  72
caccaagctt gagaccatgg agctgg                                            26


<210>  73
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Feline HER2 ECD-Fc ECD Reverse PRIMER

<400>  73
gatttgggct cggacgtcac agggctgg                                          28


<210>  74
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Feline HER2 ECD-Fc tag FORWARD PRIMER

<400>  74
ctgtgacgtc cgagcccaaa tcttgtgac                                         29


<210>  75
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Feline HER2 ECD-Fc tag Reverse PRIMER

<400>  75
tctagattat ttacccggag acagggagag gctc                                   34


<210>  76
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Black bear HER2 ECTM  (prebearHER2) FORWARD PRIMER

<400>  76
taagcttgag accatggagc tggcggcctg gtg                                    33


<210>  77
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Black bear HER2 ECTM  (prebearHER2) Reverse PRIMER

<400>  77
ctctagattc acatcgtgta cttccggatc ttc                                    33


<210>  78
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Feline GM-CSF FORWARD PRIMER

<400>  78
caccatgtgg ctgcagaacc tgcttttcct g                                      31


<210>  79
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Feline GM-CSF Reverse PRIMER

<400>  79
ttacttctgg tctggtcccc agcagtc                                           27


<210>  80
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  feCSF2 1-67 FORWARD PRIMER

<400>  80
atgtggctgc agaacctgct tttcctg                                           27


<210>  81
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  feCSF2 1-67 Reverse PRIMER

<400>  81
ctcagggtca aacatttcag agac                                              24


<210>  82
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  feCSF2 60-145 FORWARD PRIMER

<400>  82
gtctctgaaa tgtttgaccc tgagg                                             25


<210>  83
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  feCSF2 60-145 Reverse PRIMER

<400>  83
ttacttctgg tctggtcccc agcagtc                                           27


<210>  84
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Lys Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 
        675                 680                 685         


<210>  85
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Lys Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 
        675                 680                 685         


<210>  86
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asp Ser Gly Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 
        675                 680                 685         


<210>  87
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-Q141K FORWARD PRIMER

<400>  87
gctgaagctt cgaagcctca cagag                                             25


<210>  88
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-Q141K reverse PRIMER

<400>  88
tcccgcaggc ctcctgggga ggc                                               23


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-Q213K FORWARD

<400>  89
tgaggattgt aagagcctga c                                                 21


<210>  90
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-Q213K reverse

<400>  90
gaactctctc cccagcag                                                     18


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-Q239K FORWARD

<400>  91
ctgccatgag aagtgtgctg c                                                 21


<210>  92
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-Q239K reverse PRIMER

<400>  92
cagtcagtgg gcagtggc                                                     18


<210>  93
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-Q320K FORWARD PRIMER

<400>  93
aagaggtgac agcagaggat ggaac                                             25


<210>  94
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-Q320K reverse PRIMER

<400>  94
tgttgtgcag ggggcagacg ag                                                22


<210>  95
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-Q329K FORWARD PRIMER

<400>  95
ggatggaaca aagcggtgtg a                                                 21


<210>  96
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-Q329K reverse PRIMER

<400>  96
tctgctgtca cctcttgg                                                     18


<210>  97
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-Q429R FORWARD PRIMER

<400>  97
ccagaacctg agagtaatcc ggg                                               23


<210>  98
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-Q429R reverse PRIMER

<400>  98
aagacgctga ggtcaggc                                                     18


<210>  99
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-N438D FORWARD

<400>  99
aattctgcac gatggcgcct a                                                 21


<210>  100
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-N438D reverse

<400>  100
cgtccccgga ttacttgc                                                     18


<210>  101
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-NNT124DSG FORWARD PRIMER

<400>  101
ggcacacctg tcacaggggc ctccccag                                          28


<210>  102
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-NNT124DSG reverse PRIMER

<400>  102
actgtccagc gggtctccat tgtctagcac                                        30


<210>  103
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prefeHER2-Q141K FORWARD PRIMER

<400>  103
gcgggagctg aagctccgaa g                                                 21


<210>  104
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prefeHER2-Q141K reverse PRIMER

<400>  104
agccctccta gggcagcccc tgtag                                             25


<210>  105
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prefeHER2-R398Q FORWARD PRIMER

<400>  105
tgagcagctc caagtgtttg aggctctgga g                                      31


<210>  106
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prefeHER2-R398Q reverse PRIMER

<400>  106
ggctgcaggg gggcagtg                                                     18


<210>  107
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prefeHER2-N421D FORWARD PRIMER

<400>  107
cagcttgcct gacctcagtg tc                                                22


<210>  108
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prefeHER2-N421D reverse PRIMER

<400>  108
tctggccacg ctgagatg                                                     18


<210>  109
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conserved sequence in HER2, unsubstituted

<400>  109

Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile 
1               5                   10                  15  


<210>  110
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conserved sequence in HER2, with Q-K substitution

<400>  110

Lys Leu Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile 
1               5                   10                  15  


<210>  111
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prebearHER2-Q141K and mbearHER2-Q119K FORWARD primer

<400>  111
aagcctcaca gagatcctga ag                                                22


<210>  112
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prebearHER2-Q141K and mbearHER2-Q119K  REVERSE primer

<400>  112
cgaagcttca gctcccgcag ccctc                                             25


<210>  113
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  premouseHER2-Q142K and mmouseHER2-Q120K FORWARD primer

<400>  113
agtctcacag agatcttgaa gg                                                22


<210>  114
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  premouseHER2-Q142K and mmouseHER2-Q120K REVERSE primer

<400>  114
tcgaagcttc agctcccgca gccc                                              24


<210>  115
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  preratHER2-Q145K and mratHER2-Q120K FORWARD primer

<400>  115
gcttcgaagt ctcacagaga tc                                                22


<210>  116
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  preratHER2-Q145K and mratHER2-Q120K REVERSE primer

<400>  116
ttcagctccc gcagcccctc tg                                                22


<210>  117
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-Q141K and mhumHER2-Q119K FORWARD primer

<400>  117
gctgaagctt cgaagcctca cag                                               23


<210>  118
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prehumHER2-Q141K and mhumHER2-Q119K REVERSE primer

<400>  118
tcccgcaggc ctcctgggga gg                                                22


