                         SEQUENCE LISTING

<110>  ALDER BIOPHARMACEUTICALS, INC.

<120>  ANTI-ACTH ANTIBODIES AND USE THEREOF

<130>  43257.5413

<150>  62/094,763
<151>  2014-12-19

<150>  61/948,922
<151>  2014-03-06

<150>  61/948,920
<151>  2014-03-06

<150>  61/942,416
<151>  2014-02-20

<150>  61/942,280
<151>  2014-02-20

<160>  888  

<170>  PatentIn version 3.5

<210>  1
<211>  440
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1

Gln Ser Val Lys Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Asp 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Met Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys Gly Val 
                85                  90                  95      


Ser Asn His Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        115                 120                 125             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                165                 170                 175     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            180                 185                 190         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val 
        195                 200                 205             


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
305                 310                 315                 320 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440 


<210>  2
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  2

Gln Ser Val Lys Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Asp 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Met Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys Gly Val 
                85                  90                  95      


Ser Asn His Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110 


<210>  3
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  3

Gln Ser Val Lys Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  4
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  4

Asn Tyr Asp Met Ile 
1               5   


<210>  5
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  5

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  6
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  6

Met Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  7
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  7

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys 
            20                  25                  30  


<210>  8
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  8

Gly Val Ser Asn His 
1               5   


<210>  9
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  9

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  10
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  10

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  11
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  11
cagtcagtga aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtaac tatgacatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatccat cgggatgatt tatgatgatg gtgacacata ctacgcgagt      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcatc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgtca aaggtgtgag taatcactgg      300

ggcccaggca ccctcgtcac cgtctcgagc gcctccacca agggcccatc ggtcttcccc      360

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag      420

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg      480

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc      540

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc      600

aacaccaagg tggacgcgag agttgagccc aaatcttgtg acaaaactca cacatgccca      660

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      720

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      780

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      840

aagacaaagc cgcgggagga gcagtacgcc agcacgtacc gtgtggtcag cgtcctcacc      900

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      960

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1020

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1080

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1140

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1200

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1260

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1320


<210>  12
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  12
cagtcagtga aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtaac tatgacatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatccat cgggatgatt tatgatgatg gtgacacata ctacgcgagt      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcatc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgtca aaggtgtgag taatcactgg      300

ggcccaggca ccctcgtcac cgtctcgagc                                       330


<210>  13
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  13
cagtcagtga aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagt                                           87


<210>  14
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  14
aactatgaca tgatc                                                        15


<210>  15
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  15
tgggtccgcc aggctccagg gaaggggctg gaatccatcg gg                          42


<210>  16
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  16
atgatttatg atgatggtga cacatactac gcgagttggg cgaaaggc                    48


<210>  17
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  17
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatcatcag tccgacaacc       60

gaggacacgg ccacctattt ctgtgtcaaa                                        90


<210>  18
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  18
ggtgtgagta atcac                                                        15


<210>  19
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  19
tggggcccag gcaccctcgt caccgtctcg agc                                    33


<210>  20
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  20
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  21
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  21

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Gly 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  22
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  22

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Gly 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  23
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  23

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  24
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  24

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  25
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  25

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  26
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  26

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  27
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  27

Gly Val Pro Ser Arg Phe Lys Gly Arg Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  28
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  28

Gln Ser Tyr Asp Gly Ser Ser Gly Ser Ser Tyr Gly Val Gly 
1               5                   10                  


<210>  29
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  29

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  30
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  30

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  31
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  31
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattagt agttacttag cctggtatca gcagaaacca      120

gggcagcctc ccaaactcct gatctactct gcatccactc tggcatctgg ggtcccatcg      180

cggttcaaag gcaggggatc tgggacagaa ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatgatggta gtagtggtag tagttatggt      300

gttggtttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  32
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  32
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattagt agttacttag cctggtatca gcagaaacca      120

gggcagcctc ccaaactcct gatctactct gcatccactc tggcatctgg ggtcccatcg      180

cggttcaaag gcaggggatc tgggacagaa ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatgatggta gtagtggtag tagttatggt      300

gttggtttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  33
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  33
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgc                                                               69


<210>  34
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  34
caggccagtc agagcattag tagttactta gcc                                    33


<210>  35
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  35
tggtatcagc agaaaccagg gcagcctccc aaactcctga tctac                       45


<210>  36
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  36
tctgcatcca ctctggcatc t                                                 21


<210>  37
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  37
ggggtcccat cgcggttcaa aggcagggga tctgggacag aattcactct caccatcagc       60

gacctggagt gtgccgatgc tgccacttac tactgt                                 96


<210>  38
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  38
caaagctatg atggtagtag tggtagtagt tatggtgttg gt                          42


<210>  39
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  39
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  40
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  40
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  41
<211>  440
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  41

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Lys Tyr Asp 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Gln Thr Ser Thr Thr Val Asp Leu Lys Ile Ile 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys Gly Val 
                85                  90                  95      


Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        115                 120                 125             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                165                 170                 175     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            180                 185                 190         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val 
        195                 200                 205             


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
305                 310                 315                 320 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440 


<210>  42
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  42

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Lys Tyr Asp 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Gln Thr Ser Thr Thr Val Asp Leu Lys Ile Ile 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys Gly Val 
                85                  90                  95      


Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110 


<210>  43
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  43

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  44
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  44

Lys Tyr Asp Met Ile 
1               5   


<210>  45
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  45

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  46
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  46

Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  47
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  47

Arg Phe Thr Ile Ser Gln Thr Ser Thr Thr Val Asp Leu Lys Ile Ile 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys 
            20                  25                  30  


<210>  48
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  48

Gly Val Ser Asn Ile 
1               5   


<210>  49
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  49

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  50
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  50

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  51
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  51
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtaag tatgacatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatccat cgggatcatt tatgatgatg gcgacacata ttacgcgagt      180

tgggcgaaag gccgattcac catctcccaa acctcgacca cggtggatct gaaaatcatc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgtca aaggtgtgag taatatctgg      300

ggccaaggca ccctcgtcac cgtctcgagc gcctccacca agggcccatc ggtcttcccc      360

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag      420

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg      480

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc      540

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc      600

aacaccaagg tggacgcgag agttgagccc aaatcttgtg acaaaactca cacatgccca      660

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      720

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      780

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      840

aagacaaagc cgcgggagga gcagtacgcc agcacgtacc gtgtggtcag cgtcctcacc      900

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      960

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1020

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1080

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1140

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1200

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1260

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1320


<210>  52
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  52
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtaag tatgacatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatccat cgggatcatt tatgatgatg gcgacacata ttacgcgagt      180

tgggcgaaag gccgattcac catctcccaa acctcgacca cggtggatct gaaaatcatc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgtca aaggtgtgag taatatctgg      300

ggccaaggca ccctcgtcac cgtctcgagc                                       330


<210>  53
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  53
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagt                                           87


<210>  54
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  54
aagtatgaca tgatc                                                        15


<210>  55
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  55
tgggtccgcc aggctccagg gaaggggctg gaatccatcg gg                          42


<210>  56
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  56
atcatttatg atgatggcga cacatattac gcgagttggg cgaaaggc                    48


<210>  57
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  57
cgattcacca tctcccaaac ctcgaccacg gtggatctga aaatcatcag tccgacaacc       60

gaggacacgg ccacctattt ctgtgtcaaa                                        90


<210>  58
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  58
ggtgtgagta atatc                                                        15


<210>  59
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  59
tggggccaag gcaccctcgt caccgtctcg agc                                    33


<210>  60
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  60
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  61
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  61

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Thr Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Glu Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  62
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  62

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Thr Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Glu Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  63
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  63

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  64
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  64

Gln Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  65
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  65

Trp Tyr Gln Gln Lys Thr Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  66
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  66

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  67
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  67

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  68
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  68

Gln Ser Tyr Glu Gly Ser Ser Ser Ser Ser Tyr Gly Val Gly 
1               5                   10                  


<210>  69
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  69

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  70
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  70

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  71
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  71
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattagt aactacttag cctggtatca gcagaaaaca      120

gggcagcctc ccaagctcct gatctactct gcatccactc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatgagggta gtagtagtag tagttatggt      300

gttggtttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  72
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  72
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattagt aactacttag cctggtatca gcagaaaaca      120

gggcagcctc ccaagctcct gatctactct gcatccactc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatgagggta gtagtagtag tagttatggt      300

gttggtttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  73
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  73
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgc                                                               69


<210>  74
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  74
caggccagtc agagcattag taactactta gcc                                    33


<210>  75
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  75
tggtatcagc agaaaacagg gcagcctccc aagctcctga tctac                       45


<210>  76
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  76
tctgcatcca ctctggcatc t                                                 21


<210>  77
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  77
ggggtcccat cgcggttcaa aggcagtgga tctgggacag agttcactct caccatcagc       60

gacctggagt gtgccgatgc tgccacttac tactgt                                 96


<210>  78
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  78
caaagctatg agggtagtag tagtagtagt tatggtgttg gt                          42


<210>  79
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  79
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  80
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  80
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  81
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  81

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ser Ser Leu Ser Asn Phe Asp 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Ile Ile Tyr Asp Phe Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Asp Leu Lys Ile 
65                  70                  75                  80  


Ile Ser Pro Thr Ile Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys Gly 
                85                  90                  95      


Val Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  82
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  82

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ser Ser Leu Ser Asn Phe Asp 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Ile Ile Tyr Asp Phe Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Asp Leu Lys Ile 
65                  70                  75                  80  


Ile Ser Pro Thr Ile Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys Gly 
                85                  90                  95      


Val Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210>  83
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  83

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ser Ser Leu Ser 
            20                  25                  


<210>  84
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  84

Asn Phe Asp Met Ile 
1               5   


<210>  85
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  85

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  86
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  86

Ile Ile Tyr Asp Phe Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  87
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  87

Arg Phe Thr Ile Ser Arg Thr Ser Ser Thr Thr Val Asp Leu Lys Ile 
1               5                   10                  15      


Ile Ser Pro Thr Ile Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys 
            20                  25                  30      


<210>  88
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  88

Gly Val Ser Asn Ile 
1               5   


<210>  89
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  89

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  90
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  90

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  91
<211>  1323
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  91
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggatcctc cctcagtaat tttgacatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatccat cgggatcatt tatgattttg gtagcacata ctacgcgagc      180

tgggcgaaag gccgcttcac catctccaga acctcgtcga ccacggtgga tctgaaaatc      240

atcagtccga caattgagga cacggccacc tatttctgtg tcaaaggtgt gagtaatatc      300

tggggccaag gcaccctcgt caccgtctcg agcgcctcca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacgc gagagttgag cccaaatctt gtgacaaaac tcacacatgc      660

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      780

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccgcggga ggagcagtac gccagcacgt accgtgtggt cagcgtcctc      900

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa      960

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1320

aaa                                                                   1323


<210>  92
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  92
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggatcctc cctcagtaat tttgacatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatccat cgggatcatt tatgattttg gtagcacata ctacgcgagc      180

tgggcgaaag gccgcttcac catctccaga acctcgtcga ccacggtgga tctgaaaatc      240

atcagtccga caattgagga cacggccacc tatttctgtg tcaaaggtgt gagtaatatc      300

tggggccaag gcaccctcgt caccgtctcg agc                                   333


<210>  93
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  93
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggatcctc cctcagt                                           87


<210>  94
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  94
aattttgaca tgatc                                                        15


<210>  95
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  95
tgggtccgcc aggctccagg gaaggggctg gaatccatcg gg                          42


<210>  96
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  96
atcatttatg attttggtag cacatactac gcgagctggg cgaaaggc                    48


<210>  97
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  97
cgcttcacca tctccagaac ctcgtcgacc acggtggatc tgaaaatcat cagtccgaca       60

attgaggaca cggccaccta tttctgtgtc aaa                                    93


<210>  98
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  98
ggtgtgagta atatc                                                        15


<210>  99
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  99
tggggccaag gcaccctcgt caccgtctcg agc                                    33


<210>  100
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  100
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  101
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  101

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Ala Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Ile Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  102
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  102

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Ala Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Ile Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  103
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  103

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  104
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  104

Gln Ala Ser Glu Asp Ile Ser Ser Asn Leu Ala 
1               5                   10      


<210>  105
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  105

Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  106
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  106

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  107
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  107

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Ala Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  108
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  108

Gln Ser Tyr Asp Gly Ser Ser Ser Ser Ser Tyr Gly Ile Gly 
1               5                   10                  


<210>  109
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  109

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  110
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  110

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  111
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  111
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtga ggatattagt agtaatttag cctggtatca gcagaaatta      120

gggcagcctc ccaagctcct gatctactct gcatccactc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctcg ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

attggtttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  112
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  112
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtga ggatattagt agtaatttag cctggtatca gcagaaatta      120

gggcagcctc ccaagctcct gatctactct gcatccactc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctcg ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

attggtttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  113
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  113
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgc                                                               69


<210>  114
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  114
caggccagtg aggatattag tagtaattta gcc                                    33


<210>  115
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  115
tggtatcagc agaaattagg gcagcctccc aagctcctga tctac                       45


<210>  116
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  116
tctgcatcca ctctggcatc t                                                 21


<210>  117
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  117
ggggtcccat cgcggttcaa aggcagtgga tctgggacag agttcactct cgccatcagc       60

gacctggagt gtgccgatgc tgccacttac tactgt                                 96


<210>  118
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  118
caaagctatg atggtagtag tagtagtagt tatggtattg gt                          42


<210>  119
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  119
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  120
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  120
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  121
<211>  440
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  121

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Tyr Thr Val Ser Gly Phe Ser Leu Ser Lys His Asp 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys Gly Val 
                85                  90                  95      


Ser Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        115                 120                 125             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                165                 170                 175     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            180                 185                 190         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val 
        195                 200                 205             


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
305                 310                 315                 320 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440 


<210>  122
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  122

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Tyr Thr Val Ser Gly Phe Ser Leu Ser Lys His Asp 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys Gly Val 
                85                  90                  95      


Ser Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110 


<210>  123
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  123

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Tyr Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  124
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  124

Lys His Asp Met Ile 
1               5   


<210>  125
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  125

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  126
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  126

Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      


<210>  127
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  127

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys 
            20                  25                  30  


<210>  128
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  128

Gly Val Ser Asn Ile 
1               5   


<210>  129
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  129

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  130
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  130

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  131
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  131
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tacacagtct ctggattctc cctcagtaag catgacatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatccat cgggatcatt tatgatgatg gtgatacata ctacgcgaat      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcatc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgtca aaggtgtgag taatatctgg      300

ggcccaggca ccctcgtcac cgtctcgagc gcctccacca agggcccatc ggtcttcccc      360

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag      420

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg      480

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc      540

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc      600

aacaccaagg tggacgcgag agttgagccc aaatcttgtg acaaaactca cacatgccca      660

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      720

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      780

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      840

aagacaaagc cgcgggagga gcagtacgcc agcacgtacc gtgtggtcag cgtcctcacc      900

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      960

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1020

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1080

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1140

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1200

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1260

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1320


<210>  132
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  132
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tacacagtct ctggattctc cctcagtaag catgacatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatccat cgggatcatt tatgatgatg gtgatacata ctacgcgaat      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcatc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgtca aaggtgtgag taatatctgg      300

ggcccaggca ccctcgtcac cgtctcgagc                                       330


<210>  133
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  133
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tacacagtct ctggattctc cctcagt                                           87


<210>  134
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  134
aagcatgaca tgatc                                                        15


<210>  135
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  135
tgggtccgcc aggctccagg gaaggggctg gaatccatcg gg                          42


<210>  136
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  136
atcatttatg atgatggtga tacatactac gcgaattggg cgaaaggc                    48


<210>  137
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  137
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatcatcag tccgacaacc       60

gaggacacgg ccacctattt ctgtgtcaaa                                        90


<210>  138
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  138
ggtgtgagta atatc                                                        15


<210>  139
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  139
tggggcccag gcaccctcgt caccgtctcg agc                                    33


<210>  140
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  140
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  141
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  141

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Arg Ala Ser Gln Ser Ile Ser Val Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  142
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  142

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Arg Ala Ser Gln Ser Ile Ser Val Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  143
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  143

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  144
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  144

Arg Ala Ser Gln Ser Ile Ser Val Tyr Leu Ala 
1               5                   10      


<210>  145
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  145

Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  146
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  146

Gln Ala Ser Lys Leu Ala Ser 
1               5           


<210>  147
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  147

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  148
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  148

Gln Ser Tyr Asp Gly Ser Ser Ser Ser Ser Tyr Gly Val Gly 
1               5                   10                  


<210>  149
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  149

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  150
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  150

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  151
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  151
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgcc gggccagtca gagcattagt gtctacctcg cctggtatca gcagaaagca      120

gggcagcctc ccaagctcct gatctaccag gcatccaaac tggcctctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

gttggtttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  152
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  152
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgcc gggccagtca gagcattagt gtctacctcg cctggtatca gcagaaagca      120

gggcagcctc ccaagctcct gatctaccag gcatccaaac tggcctctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

gttggtttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  153
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  153
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgc                                                               69


<210>  154
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  154
cgggccagtc agagcattag tgtctacctc gcc                                    33


<210>  155
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  155
tggtatcagc agaaagcagg gcagcctccc aagctcctga tctac                       45


<210>  156
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  156
caggcatcca aactggcctc t                                                 21


<210>  157
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  157
ggggtcccat cgcggttcaa aggcagtgga tctgggacag agttcactct caccatcagc       60

gacctggagt gtgccgatgc tgccacttac tactgt                                 96


<210>  158
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  158
caaagctatg atggtagtag tagtagtagt tatggtgttg gt                          42


<210>  159
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  159
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  160
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  160
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  161
<211>  451
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  161

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Pro 
                85                  90                  95      


Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  162
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  162

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Pro 
                85                  90                  95      


Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  163
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  163

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  164
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  164

Ser Tyr Ala Met Ser 
1               5   


<210>  165
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  165

Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  166
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  166

Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  167
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  167

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  168
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  168

Glu Pro Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp Leu 
1               5                   10                  15      


<210>  169
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  169

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  170
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  170

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  171
<211>  1353
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  171
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtagc tatgcaatga gctgggtccg ccaggctcca      120

ggggaggggc tggaatggat cggaatcatt agtgatagtg gtagcacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagagcccga gtacggctac      300

gatgactatg gtgattgggt ttctgactta tggggccagg gcaccctggt caccgtctcg      360

agcgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacgc gagagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

gccagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  172
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  172
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtagc tatgcaatga gctgggtccg ccaggctcca      120

ggggaggggc tggaatggat cggaatcatt agtgatagtg gtagcacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagagcccga gtacggctac      300

gatgactatg gtgattgggt ttctgactta tggggccagg gcaccctggt caccgtctcg      360

agc                                                                    363


<210>  173
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  173
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagt                                           87


<210>  174
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  174
agctatgcaa tgagc                                                        15


<210>  175
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  175
tgggtccgcc aggctccagg ggaggggctg gaatggatcg ga                          42


<210>  176
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  176
atcattagtg atagtggtag cacatactac gcgagctggg cgaaaggc                    48


<210>  177
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  177
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatcaccag tccgacaacc       60

gaggacacgg ccacctattt ctgtgccaga                                        90


<210>  178
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  178
gagcccgagt acggctacga tgactatggt gattgggttt ctgactta                    48


<210>  179
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  179
tggggccagg gcaccctggt caccgtctcg agc                                    33


<210>  180
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  180
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  181
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  181

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Ser Ser 
                85                  90                  95      


Ser Ile Thr Tyr Arg Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  182
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  182

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Ser Ser 
                85                  90                  95      


Ser Ile Thr Tyr Arg Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Arg 
        


<210>  183
<211>  24
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  183

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys 
            20                  


<210>  184
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  184

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ser 
1               5                   10      


<210>  185
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  185

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  186
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  186

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  187
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  187

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  188
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  188

Gln Ser Tyr Tyr Tyr Ser Ser Ser Ile Thr Tyr Arg Asn Ala 
1               5                   10                  


<210>  189
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  189

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  190
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  190

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  191
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  191
gctgacattg tgatgaccca gactccagcc tccgtgtctg aacctgtggg aggcacagtc       60

accatcaagt gccaggccag tcagagcatt agtagttact tatcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctac agggcatcca ctctggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa agctattatt atagtagtag tattacttat      300

cgtaatgctt tcggcggagg gaccgaggtg gtggtcaaac gtacggtagc ggccccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  192
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  192
gctgacattg tgatgaccca gactccagcc tccgtgtctg aacctgtggg aggcacagtc       60

accatcaagt gccaggccag tcagagcatt agtagttact tatcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctac agggcatcca ctctggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa agctattatt atagtagtag tattacttat      300

cgtaatgctt tcggcggagg gaccgaggtg gtggtcaaac gt                         342


<210>  193
<211>  72
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  193
gctgacattg tgatgaccca gactccagcc tccgtgtctg aacctgtggg aggcacagtc       60

accatcaagt gc                                                           72


<210>  194
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  194
caggccagtc agagcattag tagttactta tcc                                    33


<210>  195
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  195
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctac                       45


<210>  196
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  196
agggcatcca ctctggcatc t                                                 21


<210>  197
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  197
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

gacctggagt gtgccgatgc tgccacttac tactgt                                 96


<210>  198
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  198
caaagctatt attatagtag tagtattact tatcgtaatg ct                          42


<210>  199
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  199
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  200
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  200
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  201
<211>  451
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  201

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Phe Ser Lys Thr Ser Thr Thr Val Asp Leu Arg Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Pro 
                85                  90                  95      


Glu Tyr Gly Tyr Asp Glu Tyr Gly Asp Trp Val Ser Asp Leu Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  202
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  202

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Phe Ser Lys Thr Ser Thr Thr Val Asp Leu Arg Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Pro 
                85                  90                  95      


Glu Tyr Gly Tyr Asp Glu Tyr Gly Asp Trp Val Ser Asp Leu Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  203
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  203

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  


<210>  204
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  204

Asp Tyr Ala Met Ser 
1               5   


<210>  205
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  205

Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  206
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  206

Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  207
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  207

Arg Phe Thr Phe Ser Lys Thr Ser Thr Thr Val Asp Leu Arg Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  208
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  208

Glu Pro Glu Tyr Gly Tyr Asp Glu Tyr Gly Asp Trp Val Ser Asp Leu 
1               5                   10                  15      


<210>  209
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  209

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  210
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  210

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  211
<211>  1353
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  211
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcactgac tatgcaatga gctgggtccg ccaggctcca      120

ggggaggggc tggaatggat cggaatcatt agtgatagtg gtagcacata ctacgcgagc      180

tgggcgaaag gccgattcac cttctccaaa acctcgacca cggtggatct gagaatcacc      240

agtccgacca ccgaggacac ggccacctat ttctgtgcca gagagcccga gtacggctac      300

gatgagtatg gtgattgggt ttctgactta tggggcccag gcaccctcgt caccgtctcg      360

agcgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacgc gagagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

gccagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  212
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  212
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcactgac tatgcaatga gctgggtccg ccaggctcca      120

ggggaggggc tggaatggat cggaatcatt agtgatagtg gtagcacata ctacgcgagc      180

tgggcgaaag gccgattcac cttctccaaa acctcgacca cggtggatct gagaatcacc      240

agtccgacca ccgaggacac ggccacctat ttctgtgcca gagagcccga gtacggctac      300

gatgagtatg gtgattgggt ttctgactta tggggcccag gcaccctcgt caccgtctcg      360

agc                                                                    363


<210>  213
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  213
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcact                                           87


<210>  214
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  214
gactatgcaa tgagc                                                        15


<210>  215
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  215
tgggtccgcc aggctccagg ggaggggctg gaatggatcg ga                          42


<210>  216
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  216
atcattagtg atagtggtag cacatactac gcgagctggg cgaaaggc                    48


<210>  217
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  217
cgattcacct tctccaaaac ctcgaccacg gtggatctga gaatcaccag tccgaccacc       60

gaggacacgg ccacctattt ctgtgccaga                                        90


<210>  218
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  218
gagcccgagt acggctacga tgagtatggt gattgggttt ctgactta                    48


<210>  219
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  219
tggggcccag gcaccctcgt caccgtctcg agc                                    33


<210>  220
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  220
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  221
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  221

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Ala Val Thr Ile Lys Cys Gln Ala Thr Gln Ser Ile Gly Asn 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Ser Ser 
                85                  90                  95      


Ser Ile Thr Tyr His Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  222
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  222

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Ala Val Thr Ile Lys Cys Gln Ala Thr Gln Ser Ile Gly Asn 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Ser Ser 
                85                  90                  95      


Ser Ile Thr Tyr His Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Arg 
        


<210>  223
<211>  24
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  223

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Ala Val Thr Ile Lys Cys 
            20                  


<210>  224
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  224

Gln Ala Thr Gln Ser Ile Gly Asn Asn Leu Ala 
1               5                   10      


<210>  225
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  225

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  226
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  226

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  227
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  227

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  228
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  228

Gln Ser Tyr Tyr Tyr Ser Ser Ser Ile Thr Tyr His Asn Ala 
1               5                   10                  


<210>  229
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  229

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  230
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  230

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  231
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  231
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcgcagtc       60

accatcaagt gccaggccac tcagagcatt ggtaataatt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctac agggcatcca ctctggcatc tggggtccca      180

tcgcggttca aaggcagtgg gtctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa agctattatt atagtagtag tattacttat      300

cataatgctt tcggcggagg gaccgaggtg gtggtcaaac gtacggtagc ggccccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  232
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  232
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcgcagtc       60

accatcaagt gccaggccac tcagagcatt ggtaataatt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctac agggcatcca ctctggcatc tggggtccca      180

tcgcggttca aaggcagtgg gtctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa agctattatt atagtagtag tattacttat      300

cataatgctt tcggcggagg gaccgaggtg gtggtcaaac gt                         342


<210>  233
<211>  72
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  233
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcgcagtc       60

accatcaagt gc                                                           72


<210>  234
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  234
caggccactc agagcattgg taataattta gcc                                    33


<210>  235
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  235
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctac                       45


<210>  236
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  236
agggcatcca ctctggcatc t                                                 21


<210>  237
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  237
ggggtcccat cgcggttcaa aggcagtggg tctgggacag agttcactct caccatcagc       60

gacctggagt gtgccgatgc tgccacttac tactgt                                 96


<210>  238
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  238
caaagctatt attatagtag tagtattact tatcataatg ct                          42


<210>  239
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  239
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  240
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  240
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  241
<211>  451
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  241

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Arg Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Pro 
                85                  90                  95      


Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  242
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  242

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Arg Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Pro 
                85                  90                  95      


Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  243
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  243

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  244
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  244

Ser Tyr Ala Met Ser 
1               5   


<210>  245
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  245

Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  246
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  246

Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  247
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  247

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Arg Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  248
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  248

Glu Pro Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp Leu 
1               5                   10                  15      


<210>  249
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  249

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  250
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  250

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  251
<211>  1353
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  251
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtagc tatgcaatga gctgggtccg ccaggctcca      120

ggggaggggc tggaatggat cggaatcatt agtgatagtg gtagcacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gagaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagagcccga gtacggctac      300

gatgactatg gtgattgggt ttctgactta tggggccaag gcaccctcgt caccgtctcg      360

agcgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacgc gagagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

gccagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  252
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  252
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtagc tatgcaatga gctgggtccg ccaggctcca      120

ggggaggggc tggaatggat cggaatcatt agtgatagtg gtagcacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gagaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagagcccga gtacggctac      300

gatgactatg gtgattgggt ttctgactta tggggccaag gcaccctcgt caccgtctcg      360

agc                                                                    363


<210>  253
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  253
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagt                                           87


<210>  254
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  254
agctatgcaa tgagc                                                        15


<210>  255
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  255
tgggtccgcc aggctccagg ggaggggctg gaatggatcg ga                          42


<210>  256
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  256
atcattagtg atagtggtag cacatactac gcgagctggg cgaaaggc                    48


<210>  257
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  257
cgattcacca tctccaaaac ctcgaccacg gtggatctga gaatcaccag tccgacaacc       60

gaggacacgg ccacctattt ctgtgccaga                                        90


<210>  258
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  258
gagcccgagt acggctacga tgactatggt gattgggttt ctgactta                    48


<210>  259
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  259
tggggccaag gcaccctcgt caccgtctcg agc                                    33


<210>  260
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  260
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  261
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  261

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asp 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Ser Ser 
                85                  90                  95      


Ser Ile Thr Tyr Arg Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  262
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  262

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asp 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Ser Ser 
                85                  90                  95      


Ser Ile Thr Tyr Arg Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Arg 
        


<210>  263
<211>  24
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  263

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys 
            20                  


<210>  264
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  264

Gln Ala Ser Gln Ser Ile Ser Asp Tyr Leu Ser 
1               5                   10      


<210>  265
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  265

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  266
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  266

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  267
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  267

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  268
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  268

Gln Ser Tyr Tyr Tyr Ser Ser Ser Ile Thr Tyr Arg Asn Ala 
1               5                   10                  


<210>  269
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  269

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  270
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  270

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  271
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  271
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tcagagcatt agtgattact tatcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctac agggcatcca ctctggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa agctattatt atagtagtag tattacttat      300

cgtaatgctt tcggcggagg gaccgaggtg gtggtcaaac gtacggtagc ggccccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  272
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  272
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tcagagcatt agtgattact tatcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctac agggcatcca ctctggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa agctattatt atagtagtag tattacttat      300

cgtaatgctt tcggcggagg gaccgaggtg gtggtcaaac gt                         342


<210>  273
<211>  72
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  273
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gc                                                           72


<210>  274
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  274
caggccagtc agagcattag tgattactta tcc                                    33


<210>  275
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  275
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctac                       45


<210>  276
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  276
agggcatcca ctctggcatc t                                                 21


<210>  277
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  277
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

gacctggagt gtgccgatgc tgccacttac tactgt                                 96


<210>  278
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  278
caaagctatt attatagtag tagtattact tatcgtaatg ct                          42


<210>  279
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  279
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  280
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  280
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  281
<211>  451
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  281

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Ser Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Asp Ser Gly Arg Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Pro 
                85                  90                  95      


Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp Leu Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  282
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  282

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Ser Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Asp Ser Gly Arg Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Pro 
                85                  90                  95      


Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp Leu Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  283
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  283

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn 
            20                  25                  


<210>  284
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  284

Ser Tyr Ala Met Ser 
1               5   


<210>  285
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  285

Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  286
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  286

Ile Ile Ser Asp Ser Gly Arg Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  287
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  287

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  288
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  288

Glu Pro Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp Leu 
1               5                   10                  15      


<210>  289
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  289

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  290
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  290

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  291
<211>  1353
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  291
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcaatagt tatgcaatga gctgggtccg ccaggctcca      120

ggggaggggc tggaatggat cggaatcatt agtgatagtg gtaggacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagagcccga gtacggctac      300

gatgactatg gtgattgggt ttctgactta tggggcccag gcaccctcgt caccgtctcg      360

agcgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacgc gagagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

gccagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  292
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  292
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcaatagt tatgcaatga gctgggtccg ccaggctcca      120

ggggaggggc tggaatggat cggaatcatt agtgatagtg gtaggacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagagcccga gtacggctac      300

gatgactatg gtgattgggt ttctgactta tggggcccag gcaccctcgt caccgtctcg      360

agc                                                                    363


<210>  293
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  293
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcaat                                           87


<210>  294
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  294
agttatgcaa tgagc                                                        15


<210>  295
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  295
tgggtccgcc aggctccagg ggaggggctg gaatggatcg ga                          42


<210>  296
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  296
atcattagtg atagtggtag gacatactac gcgagctggg cgaaaggc                    48


<210>  297
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  297
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatcaccag tccgacaacc       60

gaggacacgg ccacctattt ctgtgccaga                                        90


<210>  298
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  298
gagcccgagt acggctacga tgactatggt gattgggttt ctgactta                    48


<210>  299
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  299
tggggcccag gcaccctcgt caccgtctcg agc                                    33


<210>  300
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  300
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  301
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  301

Ala Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Ser Ser 
                85                  90                  95      


Ser Ile Thr Tyr Arg Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  302
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  302

Ala Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Ser Ser 
                85                  90                  95      


Ser Ile Thr Tyr Arg Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Arg 
        


<210>  303
<211>  24
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  303

Ala Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys 
            20                  


<210>  304
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  304

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ser 
1               5                   10      


<210>  305
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  305

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  306
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  306

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  307
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  307

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  308
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  308

Gln Ser Tyr Tyr Tyr Ser Ser Ser Ile Thr Tyr Arg Asn Ala 
1               5                   10                  


<210>  309
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  309

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  310
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  310

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  311
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  311
gctgacgttg tgatgaccca gactccagcc tccgtggagg ctgctgtggg aggcacagtc       60

accatcaagt gccaggccag tcagagcatt agtagttact tatcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctat agggcatcca ctctggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa agctattatt atagtagtag tattacttat      300

cgtaatgctt tcggcggagg gaccgaggtg gtggtcaaac gtacggtagc ggccccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  312
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  312
gctgacgttg tgatgaccca gactccagcc tccgtggagg ctgctgtggg aggcacagtc       60

accatcaagt gccaggccag tcagagcatt agtagttact tatcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctat agggcatcca ctctggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa agctattatt atagtagtag tattacttat      300

cgtaatgctt tcggcggagg gaccgaggtg gtggtcaaac gt                         342


<210>  313
<211>  72
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  313
gctgacgttg tgatgaccca gactccagcc tccgtggagg ctgctgtggg aggcacagtc       60

accatcaagt gc                                                           72


<210>  314
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  314
caggccagtc agagcattag tagttactta tcc                                    33


<210>  315
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  315
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctat                       45


<210>  316
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  316
agggcatcca ctctggcatc t                                                 21


<210>  317
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  317
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc       60

gacctggagt gtgccgatgc tgccacttac tactgt                                 96


<210>  318
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  318
caaagctatt attatagtag tagtattact tatcgtaatg ct                          42


<210>  319
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  319
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  320
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  320
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  321
<211>  440
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  321

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Asp 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Met Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys Gly Val 
                85                  90                  95      


Ser Ser Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        115                 120                 125             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                165                 170                 175     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            180                 185                 190         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val 
        195                 200                 205             


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
305                 310                 315                 320 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440 


<210>  322
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  322

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ala Asp 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Met Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys Gly Val 
                85                  90                  95      


Ser Ser Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110 


<210>  323
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  323

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  324
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  324

Ser Ala Asp Met Ile 
1               5   


<210>  325
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  325

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  326
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  326

Met Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  327
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  327

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ile 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys 
            20                  25                  30  


<210>  328
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  328

Gly Val Ser Ser Val 
1               5   


<210>  329
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  329

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  330
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  330

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  331
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  331
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtagc gctgacatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatccat cgggatgatt tatgatgatg gtgacacata ctacgcgact      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaagatcatc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgtca aaggtgtgag tagtgtctgg      300

ggccagggga ccctggtcac cgtctcgagc gcctccacca agggcccatc ggtcttcccc      360

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag      420

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg      480

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc      540

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc      600

aacaccaagg tggacgcgag agttgagccc aaatcttgtg acaaaactca cacatgccca      660

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      720

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      780

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      840

aagacaaagc cgcgggagga gcagtacgcc agcacgtacc gtgtggtcag cgtcctcacc      900

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      960

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1020

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1080

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1140

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1200

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1260

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1320


<210>  332
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  332
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtagc gctgacatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatccat cgggatgatt tatgatgatg gtgacacata ctacgcgact      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaagatcatc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgtca aaggtgtgag tagtgtctgg      300

ggccagggga ccctggtcac cgtctcgagc                                       330


<210>  333
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  333
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagt                                           87


<210>  334
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  334
agcgctgaca tgatc                                                        15


<210>  335
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  335
tgggtccgcc aggctccagg gaaggggctg gaatccatcg gg                          42


<210>  336
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  336
atgatttatg atgatggtga cacatactac gcgacttggg cgaaaggc                    48


<210>  337
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  337
cgattcacca tctccaaaac ctcgaccacg gtggatctga agatcatcag tccgacaacc       60

gaggacacgg ccacctattt ctgtgtcaaa                                        90


<210>  338
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  338
ggtgtgagta gtgtc                                                        15


<210>  339
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  339
tggggccagg ggaccctggt caccgtctcg agc                                    33


<210>  340
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  340
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  341
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  341

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asn Ile Tyr Arg Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  342
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  342

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asn Ile Tyr Arg Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  343
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  343

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  344
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  344

Gln Ala Ser Glu Asn Ile Tyr Arg Ser Leu Ala 
1               5                   10      


<210>  345
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  345

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  346
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  346

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  347
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  347

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  348
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  348

Gln Ser Tyr Asp Gly Ser Ser Ser Ser Ser Tyr Gly Val Gly 
1               5                   10                  


<210>  349
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  349

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  350
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  350

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  351
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  351
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaattgcc aggccagtga gaacatttac aggtctttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctactct gcatccactc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

gttggtttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  352
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  352
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaattgcc aggccagtga gaacatttac aggtctttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctactct gcatccactc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

gttggtttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  353
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  353
gatgttgtga tgacccagac tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaattgc                                                               69


<210>  354
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  354
caggccagtg agaacattta caggtcttta gcc                                    33


<210>  355
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  355
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctac                       45


<210>  356
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  356
tctgcatcca ctctggcatc t                                                 21


<210>  357
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  357
ggggtcccat cgcggttcaa aggcagtgga tctgggacag agttcactct caccatcagc       60

gacctggagt gtgccgatgc tgccacttac tactgt                                 96


<210>  358
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  358
caaagctatg atggtagtag tagtagtagt tatggtgttg gt                          42


<210>  359
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  359
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  360
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  360
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  361
<211>  440
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  361

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ala Tyr Asp 
            20                  25                  30          


Ile Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Met Met Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Ile Ile Ser Arg Thr Ser Thr Thr Met Asp Leu Lys Ile Ile 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys Gly Val 
                85                  90                  95      


Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        115                 120                 125             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                165                 170                 175     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            180                 185                 190         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val 
        195                 200                 205             


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
305                 310                 315                 320 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440 


<210>  362
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  362

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ala Tyr Asp 
            20                  25                  30          


Ile Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Met Met Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Ile Ile Ser Arg Thr Ser Thr Thr Met Asp Leu Lys Ile Ile 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys Gly Val 
                85                  90                  95      


Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110 


<210>  363
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  363

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  364
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  364

Ala Tyr Asp Ile Leu 
1               5   


<210>  365
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  365

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  366
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  366

Met Met Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  367
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  367

Arg Phe Ile Ile Ser Arg Thr Ser Thr Thr Met Asp Leu Lys Ile Ile 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys 
            20                  25                  30  


<210>  368
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  368

Gly Val Ser Asn Ile 
1               5   


<210>  369
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  369

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  370
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  370

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  371
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  371
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacatccct gacactcacc       60

tgcacagcct ctggattctc cctgagtgcc tatgacatcc tctgggtccg ccaggctcca      120

gggaagggcc tggaatccat cggaatgatg tatgatgatg gtgacacata ctacgcgact      180

tgggcgaaag gccgattcat catctccaga acctcgacca cgatggatct gaaaatcatc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgtca aaggtgtgag taatatctgg      300

ggccaaggca ccctggtcac cgtctcgagc gcctccacca agggcccatc ggtcttcccc      360

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag      420

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg      480

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc      540

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc      600

aacaccaagg tggacgcgag agttgagccc aaatcttgtg acaaaactca cacatgccca      660

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      720

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      780

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      840

aagacaaagc cgcgggagga gcagtacgcc agcacgtacc gtgtggtcag cgtcctcacc      900

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      960

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1020

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1080

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1140

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1200

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1260

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1320


<210>  372
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  372
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacatccct gacactcacc       60

tgcacagcct ctggattctc cctgagtgcc tatgacatcc tctgggtccg ccaggctcca      120

gggaagggcc tggaatccat cggaatgatg tatgatgatg gtgacacata ctacgcgact      180

tgggcgaaag gccgattcat catctccaga acctcgacca cgatggatct gaaaatcatc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgtca aaggtgtgag taatatctgg      300

ggccaaggca ccctggtcac cgtctcgagc                                       330


<210>  373
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  373
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacatccct gacactcacc       60

tgcacagcct ctggattctc cctgagt                                           87


<210>  374
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  374
gcctatgaca tcctc                                                        15


<210>  375
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  375
tgggtccgcc aggctccagg gaagggcctg gaatccatcg ga                          42


<210>  376
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  376
atgatgtatg atgatggtga cacatactac gcgacttggg cgaaaggc                    48


<210>  377
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  377
cgattcatca tctccagaac ctcgaccacg atggatctga aaatcatcag tccgacaacc       60

gaggacacgg ccacctattt ctgtgtcaaa                                        90


<210>  378
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  378
ggtgtgagta atatc                                                        15


<210>  379
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  379
tggggccaag gcaccctggt caccgtctcg agc                                    33


<210>  380
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  380
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  381
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  381

Asp Ile Val Met Thr Gln Ile Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Asp Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Tyr Tyr Gly Ile Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  382
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  382

Asp Ile Val Met Thr Gln Ile Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Asp Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Tyr Tyr Gly Ile Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  383
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  383

Asp Ile Val Met Thr Gln Ile Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  384
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  384

Gln Ala Ser Gln Ser Ile Asp Ser Ser Leu Ala 
1               5                   10      


<210>  385
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  385

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  386
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  386

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  387
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  387

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Gly Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  388
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  388

Gln Ser Tyr Asp Gly Ser Ser Ser Ser Tyr Tyr Gly Ile Gly 
1               5                   10                  


<210>  389
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  389

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  390
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  390

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  391
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  391
gacattgtga tgacccagat tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattgat agtagcttgg cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctattct gcatccactc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcggcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatgatggta gtagtagtag ttattatggt      300

attggtttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  392
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  392
gacattgtga tgacccagat tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattgat agtagcttgg cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctattct gcatccactc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcggcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatgatggta gtagtagtag ttattatggt      300

attggtttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  393
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  393
gacattgtga tgacccagat tccagcctcc gtggaggcag ctgtgggagg cacagtcacc       60

atcaagtgc                                                               69


<210>  394
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  394
caggccagtc agagcattga tagtagcttg gcc                                    33


<210>  395
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  395
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctat                       45


<210>  396
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  396
tctgcatcca ctctggcatc t                                                 21


<210>  397
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  397
ggggtcccat cgcggttcaa aggcagtgga tctgggacag agttcactct caccatcggc       60

gacctggagt gtgccgatgc tgccacttac tactgt                                 96


<210>  398
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  398
caaagctatg atggtagtag tagtagttat tatggtattg gt                          42


<210>  399
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  399
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  400
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  400
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  401
<211>  440
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  401

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ser Ser Leu Ser Asp Tyr Asp 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Arg Ile Ile 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys Gly Val 
                85                  90                  95      


Ser Asn Met Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        115                 120                 125             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                165                 170                 175     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            180                 185                 190         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val 
        195                 200                 205             


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
305                 310                 315                 320 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440 


<210>  402
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  402

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ser Ser Leu Ser Asp Tyr Asp 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Arg Ile Ile 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys Gly Val 
                85                  90                  95      


Ser Asn Met Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110 


<210>  403
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  403

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ser Ser Leu Ser 
            20                  25                  


<210>  404
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  404

Asp Tyr Asp Met Ile 
1               5   


<210>  405
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  405

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  406
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  406

Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  407
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  407

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Arg Ile Ile 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Lys 
            20                  25                  30  


<210>  408
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  408

Gly Val Ser Asn Met 
1               5   


<210>  409
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  409

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  410
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  410

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  411
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  411
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggatcctc cctcagtgat tatgacatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatccat cgggatcatt tatgatgatg gtgacacata ctacgcgact      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gagaatcatc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgtca aaggtgtgag taatatgtgg      300

ggcccgggga ccctggtcac cgtctcgagc gcctccacca agggcccatc ggtcttcccc      360

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag      420

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg      480

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc      540

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc      600

aacaccaagg tggacgcgag agttgagccc aaatcttgtg acaaaactca cacatgccca      660

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      720

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      780

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      840

aagacaaagc cgcgggagga gcagtacgcc agcacgtacc gtgtggtcag cgtcctcacc      900

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      960

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1020

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1080

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1140

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1200

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1260

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1320


<210>  412
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  412
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggatcctc cctcagtgat tatgacatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatccat cgggatcatt tatgatgatg gtgacacata ctacgcgact      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gagaatcatc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgtca aaggtgtgag taatatgtgg      300

ggcccgggga ccctggtcac cgtctcgagc                                       330


<210>  413
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  413
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggatcctc cctcagt                                           87


<210>  414
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  414
gattatgaca tgatc                                                        15


<210>  415
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  415
tgggtccgcc aggctccagg gaaggggctg gaatccatcg gg                          42


<210>  416
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  416
atcatttatg atgatggtga cacatactac gcgacttggg cgaaaggc                    48


<210>  417
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  417
cgattcacca tctccaaaac ctcgaccacg gtggatctga gaatcatcag tccgacaacc       60

gaggacacgg ccacctattt ctgtgtcaaa                                        90


<210>  418
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  418
ggtgtgagta atatg                                                        15


<210>  419
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  419
tggggcccgg ggaccctggt caccgtctcg agc                                    33


<210>  420
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  420
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  421
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  421

Asp Val Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  422
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  422

Asp Val Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  423
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  423

Asp Val Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  424
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  424

Gln Ala Ser Gln Ser Ile Gly Ser Ser Leu Ala 
1               5                   10      


<210>  425
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  425

Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  426
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  426

Ala Ala Ser Thr Leu Ala Ser 
1               5           


<210>  427
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  427

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  428
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  428

Gln Ser Tyr Asp Gly Ser Ser Ser Ser Ser Tyr Gly Val Gly 
1               5                   10                  


<210>  429
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  429

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  430
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  430

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  431
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  431
gacgtcgtga tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattggt agtagcttag cctggtatca gcagaaacca      120

gggcagcgtc ccaagctcct gatctatgct gcatccactc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

gttggtttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  432
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  432
gacgtcgtga tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattggt agtagcttag cctggtatca gcagaaacca      120

gggcagcgtc ccaagctcct gatctatgct gcatccactc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

gttggtttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  433
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  433
gacgtcgtga tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgc                                                               69


<210>  434
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  434
caggccagtc agagcattgg tagtagctta gcc                                    33


<210>  435
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  435
tggtatcagc agaaaccagg gcagcgtccc aagctcctga tctat                       45


<210>  436
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  436
gctgcatcca ctctggcatc t                                                 21


<210>  437
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  437
ggggtcccat cgcggttcaa aggcagtgga tctgggacag agttcactct caccatcagc       60

gacctggagt gtgccgatgc tgccacttac tactgt                                 96


<210>  438
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  438
caaagctatg atggtagtag tagtagtagt tatggtgttg gt                          42


<210>  439
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  439
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                    33


<210>  440
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  440
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  441
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  441

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Tyr 
            20                  25                  30          


Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Met Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Asn His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  442
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  442

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Tyr 
            20                  25                  30          


Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Met Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Asn His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  443
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  443

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  444
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  444

Asn Tyr Asp Met Ile 
1               5   


<210>  445
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  445

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  446
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  446

Met Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Ser Ser Ala Lys Gly 
1               5                   10                  15      


<210>  447
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  447

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Lys 
            20                  25                  30          


<210>  448
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  448

Gly Val Ser Asn His 
1               5   


<210>  449
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  449

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  450
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  450

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  451
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  451
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt aactatgaca tgatctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatg atttatgatg atggtgacac atactacgct      180

agttctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

aatcactggg gccaagggac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacgcgaga gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  452
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  452
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt aactatgaca tgatctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatg atttatgatg atggtgacac atactacgct      180

agttctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

aatcactggg gccaagggac cctcgtcacc gtctcgagc                             339


<210>  453
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  453
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt                                        90


<210>  454
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  454
aactatgaca tgatc                                                        15


<210>  455
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  455
tgggtccgtc aggctccagg gaaggggctg gagtccatcg ga                          42


<210>  456
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  456
atgatttatg atgatggtga cacatactac gctagttctg ctaaaggc                    48


<210>  457
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  457
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtattactgt gtcaaa                                 96


<210>  458
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  458
ggtgtgagta atcac                                                        15


<210>  459
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  459
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  460
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  460
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  461
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  461

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Gly 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  462
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  462

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Gly 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  463
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  463

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  464
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  464

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  465
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  465

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  466
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  466

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  467
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  467

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  468
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  468

Gln Ser Tyr Asp Gly Ser Ser Gly Ser Ser Tyr Gly Val Gly 
1               5                   10                  


<210>  469
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  469

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  470
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  470

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  471
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  471
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtca gagcattagt agttacttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctattct gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgatggta gtagtggtag tagttatggt      300

gttggtttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  472
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  472
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtca gagcattagt agttacttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctattct gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgatggta gtagtggtag tagttatggt      300

gttggtttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  473
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  473
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  474
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  474
caggccagtc agagcattag tagttactta gcc                                    33


<210>  475
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  475
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  476
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  476
tctgcatcca ctctggcatc t                                                 21


<210>  477
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  477
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  478
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  478
caaagctatg atggtagtag tggtagtagt tatggtgttg gt                          42


<210>  479
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  479
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  480
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  480
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  481
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  481

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Lys Tyr 
            20                  25                  30          


Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  482
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  482

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Lys Tyr 
            20                  25                  30          


Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  483
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  483

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  484
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  484

Lys Tyr Asp Met Ile 
1               5   


<210>  485
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  485

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  486
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  486

Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Ser Ser Ala Lys Gly 
1               5                   10                  15      


<210>  487
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  487

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Lys 
            20                  25                  30          


<210>  488
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  488

Gly Val Ser Asn Ile 
1               5   


<210>  489
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  489

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  490
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  490

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  491
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  491
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt aagtatgaca tgatctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatc atttatgatg atggcgacac atattacgct      180

agttctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

aatatctggg gccaagggac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacgcgaga gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  492
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  492
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt aagtatgaca tgatctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatc atttatgatg atggcgacac atattacgct      180

agttctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

aatatctggg gccaagggac cctcgtcacc gtctcgagc                             339


<210>  493
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  493
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt                                        90


<210>  494
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  494
aagtatgaca tgatc                                                        15


<210>  495
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  495
tgggtccgtc aggctccagg gaaggggctg gagtccatcg ga                          42


<210>  496
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  496
atcatttatg atgatggcga cacatattac gctagttctg ctaaaggc                    48


<210>  497
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  497
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtattactgt gtcaaa                                 96


<210>  498
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  498
ggtgtgagta atatc                                                        15


<210>  499
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  499
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  500
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  500
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  501
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  501

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Glu Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  502
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  502

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Glu Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  503
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  503

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  504
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  504

Gln Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  505
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  505

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  506
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  506

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  507
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  507

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  508
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  508

Gln Ser Tyr Glu Gly Ser Ser Ser Ser Ser Tyr Gly Val Gly 
1               5                   10                  


<210>  509
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  509

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  510
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  510

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  511
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  511
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtca gagcattagt aactacttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctattct gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgagggta gtagtagtag tagttatggt      300

gttggtttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  512
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  512
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtca gagcattagt aactacttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctattct gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgagggta gtagtagtag tagttatggt      300

gttggtttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  513
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  513
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  514
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  514
caggccagtc agagcattag taactactta gcc                                    33


<210>  515
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  515
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  516
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  516
tctgcatcca ctctggcatc t                                                 21


<210>  517
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  517
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  518
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  518
caaagctatg agggtagtag tagtagtagt tatggtgttg gt                          42


<210>  519
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  519
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  520
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  520
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  521
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  521

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Leu Ser Asn Phe 
            20                  25                  30          


Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Ile Ile Tyr Asp Phe Gly Ser Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  522
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  522

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Leu Ser Asn Phe 
            20                  25                  30          


Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Ile Ile Tyr Asp Phe Gly Ser Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  523
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  523

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Leu Ser 
            20                  25                  30  


<210>  524
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  524

Asn Phe Asp Met Ile 
1               5   


<210>  525
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  525

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  526
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  526

Ile Ile Tyr Asp Phe Gly Ser Thr Tyr Tyr Ala Ser Ser Ala Lys Gly 
1               5                   10                  15      


<210>  527
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  527

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Lys 
            20                  25                  30          


<210>  528
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  528

Gly Val Ser Asn Ile 
1               5   


<210>  529
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  529

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  530
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  530

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  531
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  531
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggttc ctccctcagt aactttgaca tgatctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatc atttatgatt ttggtagcac atactacgcc      180

agctctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

aatatctggg gccaagggac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacgcgaga gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  532
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  532
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggttc ctccctcagt aactttgaca tgatctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatc atttatgatt ttggtagcac atactacgcc      180

agctctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

aatatctggg gccaagggac cctcgtcacc gtctcgagc                             339


<210>  533
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  533
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggttc ctccctcagt                                        90


<210>  534
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  534
aactttgaca tgatc                                                        15


<210>  535
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  535
tgggtccgtc aggctccagg gaaggggctg gagtccatcg ga                          42


<210>  536
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  536
atcatttatg attttggtag cacatactac gccagctctg ctaaaggc                    48


<210>  537
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  537
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtattactgt gtcaaa                                 96


<210>  538
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  538
ggtgtgagta atatc                                                        15


<210>  539
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  539
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  540
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  540
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  541
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  541

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Ile Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  542
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  542

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Ile Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  543
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  543

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  544
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  544

Gln Ala Ser Glu Asp Ile Ser Ser Asn Leu Ala 
1               5                   10      


<210>  545
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  545

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  546
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  546

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  547
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  547

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  548
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  548

Gln Ser Tyr Asp Gly Ser Ser Ser Ser Ser Tyr Gly Ile Gly 
1               5                   10                  


<210>  549
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  549

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  550
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  550

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  551
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  551
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtga ggatattagt agtaacttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctattct gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa tttactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

attggtttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  552
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  552
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtga ggatattagt agtaacttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctattct gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa tttactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

attggtttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  553
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  553
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  554
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  554
caggccagtg aggatattag tagtaactta gcc                                    33


<210>  555
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  555
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  556
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  556
tctgcatcca ctctggcatc t                                                 21


<210>  557
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  557
ggagtcccat caaggttcag cggcagtgga tctggaacag aatttactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  558
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  558
caaagctatg atggtagtag tagtagtagt tatggtattg gt                          42


<210>  559
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  559
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  560
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  560
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  561
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  561

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Lys His 
            20                  25                  30          


Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Asn Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  562
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  562

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Lys His 
            20                  25                  30          


Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Asn Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  563
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  563

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  564
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  564

Lys His Asp Met Ile 
1               5   


<210>  565
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  565

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  566
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  566

Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Asn Ser Ala Lys Gly 
1               5                   10                  15      


<210>  567
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  567

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Lys 
            20                  25                  30          


<210>  568
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  568

Gly Val Ser Asn Ile 
1               5   


<210>  569
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  569

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  570
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  570

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  571
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  571
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt aagcatgaca tgatctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatc atttatgatg atggtgatac atactacgct      180

aattctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

aatatctggg gccaagggac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacgcgaga gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  572
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  572
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt aagcatgaca tgatctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatc atttatgatg atggtgatac atactacgct      180

aattctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

aatatctggg gccaagggac cctcgtcacc gtctcgagc                             339


<210>  573
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  573
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt                                        90


<210>  574
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  574
aagcatgaca tgatc                                                        15


<210>  575
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  575
tgggtccgtc aggctccagg gaaggggctg gagtccatcg ga                          42


<210>  576
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  576
atcatttatg atgatggtga tacatactac gctaattctg ctaaaggc                    48


<210>  577
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  577
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtattactgt gtcaaa                                 96


<210>  578
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  578
ggtgtgagta atatc                                                        15


<210>  579
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  579
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  580
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  580
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  581
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  581

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Val Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  582
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  582

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Val Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  583
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  583

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  584
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  584

Arg Ala Ser Gln Ser Ile Ser Val Tyr Leu Ala 
1               5                   10      


<210>  585
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  585

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  586
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  586

Gln Ala Ser Lys Leu Ala Ser 
1               5           


<210>  587
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  587

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  588
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  588

Gln Ser Tyr Asp Gly Ser Ser Ser Ser Ser Tyr Gly Val Gly 
1               5                   10                  


<210>  589
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  589

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  590
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  590

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  591
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  591
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgta gagccagtca gagcattagt gtctacctcg cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctatcag gcatccaaac tggcctctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

gttggtttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  592
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  592
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgta gagccagtca gagcattagt gtctacctcg cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctatcag gcatccaaac tggcctctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

gttggtttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  593
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  593
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  594
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  594
agagccagtc agagcattag tgtctacctc gcc                                    33


<210>  595
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  595
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  596
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  596
caggcatcca aactggcctc t                                                 21


<210>  597
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  597
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  598
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  598
caaagctatg atggtagtag tagtagtagt tatggtgttg gt                          42


<210>  599
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  599
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  600
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  600
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  601
<211>  454
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  601

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Pro Glu Tyr Gly Tyr Asp Glu Tyr Gly Asp Trp Val Ser Asp 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  602
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  602

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Pro Glu Tyr Gly Tyr Asp Glu Tyr Gly Asp Trp Val Ser Asp 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  603
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  603

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  604
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  604

Asp Tyr Ala Met Ser 
1               5   


<210>  605
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  605

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  606
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  606

Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Ser Ala Lys Gly 
1               5                   10                  15      


<210>  607
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  607

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  608
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  608

Glu Pro Glu Tyr Gly Tyr Asp Glu Tyr Gly Asp Trp Val Ser Asp Leu 
1               5                   10                  15      


<210>  609
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  609

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  610
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  610

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  611
<211>  1362
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  611
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcact gactatgcaa tgagctgggt ccgtcaggct      120

ccagggaagg ggctggagtg gatcggaatc attagtgata gtggtagcac atactacgct      180

agctctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agagcccgag      300

tacggctacg atgagtatgg tgattgggtt tctgacttat ggggccaagg gaccctcgtc      360

accgtctcga gcgcctccac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacgcg      660

agagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      720

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      780

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      840

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      900

gagcagtacg ccagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      960

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1020

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1080

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1140

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1200

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1260

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1320

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        1362


<210>  612
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  612
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcact gactatgcaa tgagctgggt ccgtcaggct      120

ccagggaagg ggctggagtg gatcggaatc attagtgata gtggtagcac atactacgct      180

agctctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agagcccgag      300

tacggctacg atgagtatgg tgattgggtt tctgacttat ggggccaagg gaccctcgtc      360

accgtctcga gc                                                          372


<210>  613
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  613
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcact                                        90


<210>  614
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  614
gactatgcaa tgagc                                                        15


<210>  615
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  615
tgggtccgtc aggctccagg gaaggggctg gagtggatcg ga                          42


<210>  616
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  616
atcattagtg atagtggtag cacatactac gctagctctg ctaaaggc                    48


<210>  617
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  617
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtattactgt gctaga                                 96


<210>  618
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  618
gagcccgagt acggctacga tgagtatggt gattgggttt ctgactta                    48


<210>  619
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  619
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  620
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  620
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  621
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  621

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Thr Gln Ser Ile Gly Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ile Thr Tyr His Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  622
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  622

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Thr Gln Ser Ile Gly Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ile Thr Tyr His Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  623
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  623

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  624
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  624

Gln Ala Thr Gln Ser Ile Gly Asn Asn Leu Ala 
1               5                   10      


<210>  625
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  625

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  626
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  626

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  627
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  627

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  628
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  628

Gln Ser Tyr Tyr Tyr Ser Ser Ser Ile Thr Tyr His Asn Ala 
1               5                   10                  


<210>  629
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  629

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  630
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  630

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  631
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  631
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccactca gagcattggt aataacttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctatagg gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tattactata gtagtagtat tacttatcat      300

aatgctttcg gcggaggaac caaggtggaa atcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  632
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  632
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccactca gagcattggt aataacttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctatagg gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tattactata gtagtagtat tacttatcat      300

aatgctttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  633
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  633
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  634
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  634
caggccactc agagcattgg taataactta gcc                                    33


<210>  635
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  635
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  636
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  636
agggcatcca ctctggcatc t                                                 21


<210>  637
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  637
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  638
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  638
caaagctatt actatagtag tagtattact tatcataatg ct                          42


<210>  639
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  639
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  640
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  640
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  641
<211>  454
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  641

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Pro Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  642
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  642

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Pro Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  643
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  643

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
            20                  25                  30  


<210>  644
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  644

Ser Tyr Ala Met Ser 
1               5   


<210>  645
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  645

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  646
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  646

Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Ser Ala Lys Gly 
1               5                   10                  15      


<210>  647
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  647

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  648
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  648

Glu Pro Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp Leu 
1               5                   10                  15      


<210>  649
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  649

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  650
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  650

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  651
<211>  1362
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  651
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt agctatgcaa tgagctgggt ccgtcaggct      120

ccagggaagg ggctggagtg gatcggaatc attagtgata gtggtagcac atactacgcg      180

agctctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agagcccgag      300

tacggctacg atgactatgg tgattgggtt tctgacttat ggggccaagg gaccctcgtc      360

accgtctcga gcgcctccac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacgcg      660

agagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      720

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      780

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      840

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      900

gagcagtacg ccagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      960

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1020

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1080

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1140

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1200

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1260

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1320

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        1362


<210>  652
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  652
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt agctatgcaa tgagctgggt ccgtcaggct      120

ccagggaagg ggctggagtg gatcggaatc attagtgata gtggtagcac atactacgcg      180

agctctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agagcccgag      300

tacggctacg atgactatgg tgattgggtt tctgacttat ggggccaagg gaccctcgtc      360

accgtctcga gc                                                          372


<210>  653
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  653
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt                                        90


<210>  654
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  654
agctatgcaa tgagc                                                        15


<210>  655
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  655
tgggtccgtc aggctccagg gaaggggctg gagtggatcg ga                          42


<210>  656
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  656
atcattagtg atagtggtag cacatactac gcgagctctg ctaaaggc                    48


<210>  657
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  657
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtattactgt gctaga                                 96


<210>  658
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  658
gagcccgagt acggctacga tgactatggt gattgggttt ctgactta                    48


<210>  659
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  659
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  660
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  660
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  661
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  661

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ile Thr Tyr Arg Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  662
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  662

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ile Thr Tyr Arg Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  663
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  663

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  664
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  664

Gln Ala Ser Gln Ser Ile Ser Asp Tyr Leu Ser 
1               5                   10      


<210>  665
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  665

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  666
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  666

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  667
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  667

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  668
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  668

Gln Ser Tyr Tyr Tyr Ser Ser Ser Ile Thr Tyr Arg Asn Ala 
1               5                   10                  


<210>  669
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  669

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  670
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  670

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  671
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  671
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtca gagcattagt gattacttat cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctatagg gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tattactata gtagtagtat tacttatcgt      300

aatgctttcg gcggaggaac caaggtggaa atcaaacgta cggtagcggc cccatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  672
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  672
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtca gagcattagt gattacttat cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctatagg gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tattactata gtagtagtat tacttatcgt      300

aatgctttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  673
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  673
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  674
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  674
caggccagtc agagcattag tgattactta tcc                                    33


<210>  675
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  675
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  676
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  676
agggcatcca ctctggcatc t                                                 21


<210>  677
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  677
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  678
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  678
caaagctatt actatagtag tagtattact tatcgtaatg ct                          42


<210>  679
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  679
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  680
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  680
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  681
<211>  454
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  681

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Pro Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  682
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  682

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Pro Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  683
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  683

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
            20                  25                  30  


<210>  684
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  684

Ser Tyr Ala Met Ser 
1               5   


<210>  685
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  685

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  686
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  686

Ile Ile Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Ser Ser Ala Lys Gly 
1               5                   10                  15      


<210>  687
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  687

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  688
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  688

Glu Pro Glu Tyr Gly Tyr Asp Asp Tyr Gly Asp Trp Val Ser Asp Leu 
1               5                   10                  15      


<210>  689
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  689

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  690
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  690

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  691
<211>  1362
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  691
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt agctatgcaa tgagctgggt ccgtcaggct      120

ccagggaagg ggctggagtg gatcggaatc attagtgata gtggtagcac atactacgcg      180

agctctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agagcccgag      300

tacggctacg atgactatgg tgattgggtt tctgacttat ggggccaagg gaccctcgtc      360

accgtctcga gcgcctccac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacgcg      660

agagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      720

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      780

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      840

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      900

gagcagtacg ccagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      960

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1020

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1080

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1140

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1200

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1260

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1320

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        1362


<210>  692
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  692
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt agctatgcaa tgagctgggt ccgtcaggct      120

ccagggaagg ggctggagtg gatcggaatc attagtgata gtggtagcac atactacgcg      180

agctctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agagcccgag      300

tacggctacg atgactatgg tgattgggtt tctgacttat ggggccaagg gaccctcgtc      360

accgtctcga gc                                                          372


<210>  693
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  693
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagt                                        90


<210>  694
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  694
agctatgcaa tgagc                                                        15


<210>  695
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  695
tgggtccgtc aggctccagg gaaggggctg gagtggatcg ga                          42


<210>  696
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  696
atcattagtg atagtggtag cacatactac gcgagctctg ctaaaggc                    48


<210>  697
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  697
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtattactgt gctaga                                 96


<210>  698
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  698
gagcccgagt acggctacga tgactatggt gattgggttt ctgactta                    48


<210>  699
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  699
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  700
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  700
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  701
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  701

Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asp 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Ser Ser 
                85                  90                  95      


Ser Ile Thr Tyr Arg Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  702
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  702

Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asp 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Ser Ser 
                85                  90                  95      


Ser Ile Thr Tyr Arg Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  703
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  703

Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys 
            20                  


<210>  704
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  704

Gln Ala Ser Gln Ser Ile Ser Asp Tyr Leu Ser 
1               5                   10      


<210>  705
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  705

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  706
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  706

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  707
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  707

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  708
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  708

Gln Ser Tyr Tyr Tyr Ser Ser Ser Ile Thr Tyr Arg Asn Ala 
1               5                   10                  


<210>  709
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  709

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  710
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  710

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  711
<211>  660
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  711
gctgacatcc agatgaccca gtctccttcc accctgtctg catctgtagg agacagagtc       60

accatcactt gtcaggccag tcagagcatt agtgattact tatcctggta tcagcagaaa      120

ccaggaaaag cccctaagct cctgatctat agggcatcca ctctggcatc tggagtccca      180

tcaaggttca gcggcagtgg atctggaaca gaattcactc tcaccatcag cagcctgcag      240

cctgatgatt ttgcaactta ctactgtcaa agctattact atagtagtag tattacttat      300

cgtaatgctt tcggcggagg aaccaaggtg gaaatcaaac gtacggtagc ggccccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  712
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  712
gctgacatcc agatgaccca gtctccttcc accctgtctg catctgtagg agacagagtc       60

accatcactt gtcaggccag tcagagcatt agtgattact tatcctggta tcagcagaaa      120

ccaggaaaag cccctaagct cctgatctat agggcatcca ctctggcatc tggagtccca      180

tcaaggttca gcggcagtgg atctggaaca gaattcactc tcaccatcag cagcctgcag      240

cctgatgatt ttgcaactta ctactgtcaa agctattact atagtagtag tattacttat      300

cgtaatgctt tcggcggagg aaccaaggtg gaaatcaaac gt                         342


<210>  713
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  713
gctgacatcc agatgaccca gtctccttcc accctgtctg catctgtagg agacagagtc       60

accatcactt gt                                                           72


<210>  714
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  714
caggccagtc agagcattag tgattactta tcc                                    33


<210>  715
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  715
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  716
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  716
agggcatcca ctctggcatc t                                                 21


<210>  717
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  717
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  718
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  718
caaagctatt actatagtag tagtattact tatcgtaatg ct                          42


<210>  719
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  719
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  720
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  720
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  721
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  721

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Ala 
            20                  25                  30          


Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Met Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Ser Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  722
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  722

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Ala 
            20                  25                  30          


Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Met Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Ser Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  723
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  723

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  724
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  724

Ser Ala Asp Met Ile 
1               5   


<210>  725
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  725

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  726
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  726

Met Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Ser Ala Lys Gly 
1               5                   10                  15      


<210>  727
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  727

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Lys 
            20                  25                  30          


<210>  728
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  728

Gly Val Ser Ser Val 
1               5   


<210>  729
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  729

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  730
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  730

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  731
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  731
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcgctgaca tgatctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatg atttatgatg atggtgacac atactacgct      180

acttctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

agtgtctggg gccaagggac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacgcgaga gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  732
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  732
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcgctgaca tgatctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatg atttatgatg atggtgacac atactacgct      180

acttctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

agtgtctggg gccaagggac cctcgtcacc gtctcgagc                             339


<210>  733
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  733
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt                                        90


<210>  734
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  734
agcgctgaca tgatc                                                        15


<210>  735
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  735
tgggtccgtc aggctccagg gaaggggctg gagtccatcg ga                          42


<210>  736
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  736
atgatttatg atgatggtga cacatactac gctacttctg ctaaaggc                    48


<210>  737
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  737
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtattactgt gtcaaa                                 96


<210>  738
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  738
ggtgtgagta gtgtc                                                        15


<210>  739
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  739
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  740
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  740
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  741
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  741

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Arg Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  742
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  742

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Arg Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  743
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  743

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  744
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  744

Gln Ala Ser Glu Asn Ile Tyr Arg Ser Leu Ala 
1               5                   10      


<210>  745
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  745

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  746
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  746

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  747
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  747

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  748
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  748

Gln Ser Tyr Asp Gly Ser Ser Ser Ser Ser Tyr Gly Val Gly 
1               5                   10                  


<210>  749
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  749

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  750
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  750

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  751
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  751
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtga gaacatttac aggtctttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctattct gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

gttggtttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  752
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  752
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtga gaacatttac aggtctttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctattct gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

gttggtttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  753
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  753
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  754
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  754
caggccagtg agaacattta caggtcttta gcc                                    33


<210>  755
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  755
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  756
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  756
tctgcatcca ctctggcatc t                                                 21


<210>  757
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  757
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  758
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  758
caaagctatg atggtagtag tagtagtagt tatggtgttg gt                          42


<210>  759
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  759
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  760
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  760
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  761
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  761

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Tyr 
            20                  25                  30          


Asp Ile Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Met Met Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  762
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  762

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Tyr 
            20                  25                  30          


Asp Ile Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Met Met Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  763
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  763

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  764
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  764

Ala Tyr Asp Ile Leu 
1               5   


<210>  765
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  765

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  766
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  766

Met Met Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Ser Ala Lys Gly 
1               5                   10                  15      


<210>  767
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  767

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Lys 
            20                  25                  30          


<210>  768
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  768

Gly Val Ser Asn Ile 
1               5   


<210>  769
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  769

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  770
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  770

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  771
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  771
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt gcctatgaca tcctctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatg atgtatgatg atggtgacac atactacgct      180

acttctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

aatatctggg gccaagggac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacgcgaga gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  772
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  772
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt gcctatgaca tcctctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatg atgtatgatg atggtgacac atactacgct      180

acttctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

aatatctggg gccaagggac cctcgtcacc gtctcgagc                             339


<210>  773
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  773
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt                                        90


<210>  774
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  774
gcctatgaca tcctc                                                        15


<210>  775
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  775
tgggtccgtc aggctccagg gaaggggctg gagtccatcg ga                          42


<210>  776
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  776
atgatgtatg atgatggtga cacatactac gctacttctg ctaaaggc                    48


<210>  777
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  777
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtattactgt gtcaaa                                 96


<210>  778
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  778
ggtgtgagta atatc                                                        15


<210>  779
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  779
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  780
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  780
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  781
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  781

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Tyr Tyr Gly Ile Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  782
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  782

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Tyr Tyr Gly Ile Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  783
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  783

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  784
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  784

Gln Ala Ser Gln Ser Ile Asp Ser Ser Leu Ala 
1               5                   10      


<210>  785
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  785

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  786
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  786

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  787
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  787

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  788
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  788

Gln Ser Tyr Asp Gly Ser Ser Ser Ser Tyr Tyr Gly Ile Gly 
1               5                   10                  


<210>  789
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  789

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  790
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  790

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  791
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  791
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtca gagcattgat agtagcttgg cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctattct gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgatggta gtagtagtag ttactatggt      300

attggtttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  792
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  792
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtca gagcattgat agtagcttgg cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctattct gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgatggta gtagtagtag ttactatggt      300

attggtttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  793
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  793
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  794
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  794
caggccagtc agagcattga tagtagcttg gcc                                    33


<210>  795
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  795
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  796
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  796
tctgcatcca ctctggcatc t                                                 21


<210>  797
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  797
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  798
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  798
caaagctatg atggtagtag tagtagttac tatggtattg gt                          42


<210>  799
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  799
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  800
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  800
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  801
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  801

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Tyr 
            20                  25                  30          


Asp Ile Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Met Met Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  802
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  802

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Tyr 
            20                  25                  30          


Asp Ile Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Met Met Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  803
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  803

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  804
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  804

Ala Tyr Asp Ile Leu 
1               5   


<210>  805
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  805

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  806
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  806

Met Met Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Ser Ala Lys Gly 
1               5                   10                  15      


<210>  807
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  807

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Lys 
            20                  25                  30          


<210>  808
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  808

Gly Val Ser Asn Ile 
1               5   


<210>  809
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  809

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  810
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  810

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  811
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  811
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt gcctatgaca tcctctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatg atgtatgatg atggtgacac atactacgct      180

acttctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

aatatctggg gccaagggac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  812
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  812
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt gcctatgaca tcctctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatg atgtatgatg atggtgacac atactacgct      180

acttctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

aatatctggg gccaagggac cctcgtcacc gtctcgagc                             339


<210>  813
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  813
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt                                        90


<210>  814
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  814
gcctatgaca tcctc                                                        15


<210>  815
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  815
tgggtccgtc aggctccagg gaaggggctg gagtccatcg ga                          42


<210>  816
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  816
atgatgtatg atgatggtga cacatactac gctacttctg ctaaaggc                    48


<210>  817
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  817
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtattactgt gtcaaa                                 96


<210>  818
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  818
ggtgtgagta atatc                                                        15


<210>  819
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  819
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  820
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  820
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  821
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  821

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Glu Gly Ser Ser Ser 
                85                  90                  95      


Ser Tyr Tyr Gly Ile Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  822
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  822

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Glu Gly Ser Ser Ser 
                85                  90                  95      


Ser Tyr Tyr Gly Ile Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  823
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  823

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  824
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  824

Gln Ala Ser Gln Ser Ile Gly Ser Ser Leu Ala 
1               5                   10      


<210>  825
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  825

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  826
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  826

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  827
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  827

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  828
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  828

Gln Ser Tyr Glu Gly Ser Ser Ser Ser Tyr Tyr Gly Ile Gly 
1               5                   10                  


<210>  829
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  829

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  830
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  830

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  831
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  831
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtca gagcattggt agtagcttgg cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctattct gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgaaggta gtagtagtag ttactatggt      300

attggtttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  832
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  832
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtca gagcattggt agtagcttgg cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctattct gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgaaggta gtagtagtag ttactatggt      300

attggtttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  833
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  833
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  834
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  834
caggccagtc agagcattgg tagtagcttg gcc                                    33


<210>  835
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  835
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  836
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  836
tctgcatcca ctctggcatc t                                                 21


<210>  837
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  837
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  838
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  838
caaagctatg aaggtagtag tagtagttac tatggtattg gt                          42


<210>  839
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  839
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  840
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  840
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  841
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  841

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Leu Ser Asp Tyr 
            20                  25                  30          


Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Asn Met Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Ala Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  842
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  842

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Leu Ser Asp Tyr 
            20                  25                  30          


Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile 
        35                  40                  45              


Gly Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Lys Gly Val Ser Asn Met Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  843
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  843

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Leu Ser 
            20                  25                  30  


<210>  844
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  844

Asp Tyr Asp Met Ile 
1               5   


<210>  845
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  845

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
1               5                   10                  


<210>  846
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  846

Ile Ile Tyr Asp Asp Gly Asp Thr Tyr Tyr Ala Thr Ser Ala Lys Gly 
1               5                   10                  15      


<210>  847
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  847

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Lys 
            20                  25                  30          


<210>  848
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  848

Gly Val Ser Asn Met 
1               5   


<210>  849
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  849

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  850
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  850

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  851
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  851
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatc ctccctcagt gattatgaca tgatctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatc atttatgatg atggtgacac atactacgct      180

acttctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

aatatgtggg gccaagggac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacgcgaga gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  852
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  852
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatc ctccctcagt gattatgaca tgatctgggt ccgtcaggct      120

ccagggaagg ggctggagtc catcggaatc atttatgatg atggtgacac atactacgct      180

acttctgcta aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt      240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgtcaa aggtgtgagt      300

aatatgtggg gccaagggac cctcgtcacc gtctcgagc                             339


<210>  853
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  853
gaggtgcagc ttgtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatc ctccctcagt                                        90


<210>  854
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  854
gattatgaca tgatc                                                        15


<210>  855
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  855
tgggtccgtc aggctccagg gaaggggctg gagtccatcg ga                          42


<210>  856
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  856
atcatttatg atgatggtga cacatactac gctacttctg ctaaaggc                    48


<210>  857
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  857
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg       60

agagctgagg acactgctgt gtattactgt gtcaaa                                 96


<210>  858
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  858
ggtgtgagta atatg                                                        15


<210>  859
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  859
tggggccaag ggaccctcgt caccgtctcg agc                                    33


<210>  860
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  860
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  861
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  861

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  862
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  862

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Gly Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  863
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  863

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  864
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  864

Gln Ala Ser Gln Ser Ile Gly Ser Ser Leu Ala 
1               5                   10      


<210>  865
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  865

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  866
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  866

Ala Ala Ser Thr Leu Ala Ser 
1               5           


<210>  867
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  867

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  868
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  868

Gln Ser Tyr Asp Gly Ser Ser Ser Ser Ser Tyr Gly Val Gly 
1               5                   10                  


<210>  869
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  869

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  870
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  870

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  871
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  871
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtca gagcattggt agtagcttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctatgct gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

gttggtttcg gcggaggaac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  872
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  872
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc aggccagtca gagcattggt agtagcttag cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatctatgct gcatccactc tggcatctgg agtcccatca      180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttacta ctgtcaaagc tatgatggta gtagtagtag tagttatggt      300

gttggtttcg gcggaggaac caaggtggaa atcaaacgt                             339


<210>  873
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  873
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgt                                                               69


<210>  874
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  874
caggccagtc agagcattgg tagtagctta gcc                                    33


<210>  875
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  875
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                       45


<210>  876
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  876
gctgcatcca ctctggcatc t                                                 21


<210>  877
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  877
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc       60

agcctgcagc ctgatgattt tgcaacttac tactgt                                 96


<210>  878
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  878
caaagctatg atggtagtag tagtagtagt tatggtgttg gt                          42


<210>  879
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  879
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                    33


<210>  880
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  880
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  881
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  881

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Asn Gly Ala Glu Asp Glu Ser Ala 
            20                  25                  30          


Glu Ala Phe Pro Leu Glu Phe 
        35                  


<210>  882
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  882

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro 
            20                  


<210>  883
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  883

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val 
1               5                   10              


<210>  884
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  884

Arg Pro Val Lys Val Tyr Pro Asn Gly Ala Glu Asp Glu Ser Ala Glu 
1               5                   10                  15      


Ala Phe Pro Leu Glu Phe 
            20          


<210>  885
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Acetylation
<222>  (1)..(1)

<220>
<221>  Amidation
<222>  (13)..(13)

<400>  885

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val 
1               5                   10              


<210>  886
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  886

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  887
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  887

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  888
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  888

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

