                         SEQUENCE LISTING

<110>  AZZAZY, HASSAN
       BALHORN, RODNEY
       AL OLABY, REEM
 
<120>  LIGANDS THAT TARGET HEPATITIS C VIRUS E2 PROTEIN

<130>  428992WO

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  303
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(303)
<223>  HCV E2 polypeptide tr|C4MR37|384-746

<400>  1

Tyr Asn Lys Phe Asn Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys 
1               5                   10                  15      


Arg Pro Leu Thr Asp Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala 
            20                  25                  30          


Asn Gly Ser Gly Pro Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro 
        35                  40                  45              


Arg Pro Cys Gly Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr 
    50                  55                  60                  


Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly 
65                  70                  75                  80  


Ala Pro Thr Tyr Ser Trp Gly Glu Asn Glu Thr Asp Val Phe Ile Leu 
                85                  90                  95      


Asn Asn Thr Arg Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met 
            100                 105                 110         


Asn Ser Ser Gly Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile 
        115                 120                 125             


Gly Gly Val Gly Asn Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg 
    130                 135                 140                 


Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile 
145                 150                 155                 160 


Thr Pro Arg Cys Leu Val Asn Tyr Pro Tyr Arg Leu Trp His Tyr Pro 
                165                 170                 175     


Cys Thr Ile Asn Tyr Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly 
            180                 185                 190         


Val Glu His Arg Leu Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg 
        195                 200                 205             


Cys Asp Leu Glu Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu 
    210                 215                 220                 


Ser Thr Thr Gln Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro 
225                 230                 235                 240 


Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val 
                245                 250                 255     


Gln Tyr Leu Tyr Gly Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys 
            260                 265                 270         


Trp Asp Tyr Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val 
        275                 280                 285             


Cys Ser Cys Leu Trp Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
    290                 295                 300             


<210>  2
<211>  236
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(236)
<223>  CD81 AMINO ACID SEQUENCE NP_004347.1

<400>  2

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
225                 230                 235     


<210>  3
<211>  90
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(90)
<223>  CD81 Chain A amino acid sequence. Re: Crystal Structure Of Human 
       CD81 Extracellular Domain 1G8Q_A  GI:13399775

<400>  3

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
            20                  25                  30          


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys His 
                85                  90  


<210>  4
<211>  90
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(90)
<223>  CD81 Chain B amino acid sequence.  Re: Crystal Structure Of Human
       CD81 Extracellular Domain 1G8Q_B  GI:13399776.

<400>  4

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
            20                  25                  30          


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys His 
                85                  90  


<210>  5
<211>  363
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(363)
<223>  P26664[384-746], Genome polyprotein, Hepatitis C virus genotype 
       1a (isolate 1)

<400>  5

Glu Thr His Val Thr Gly Gly Ser Ala Gly His Thr Val Ser Gly Phe 
1               5                   10                  15      


Val Ser Leu Leu Ala Pro Gly Ala Lys Gln Asn Val Gln Leu Ile Asn 
            20                  25                  30          


Thr Asn Gly Ser Trp His Leu Asn Ser Thr Ala Leu Asn Cys Asn Asp 
        35                  40                  45              


Ser Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr His His Lys Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr 
65                  70                  75                  80  


Asp Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly 
                85                  90                  95      


Pro Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly 
            100                 105                 110         


Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
        115                 120                 125             


Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr 
    130                 135                 140                 


Ser Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg 
145                 150                 155                 160 


Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
                165                 170                 175     


Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Ala Gly 
            180                 185                 190         


Asn Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp 
        195                 200                 205             


Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys 
    210                 215                 220                 


Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn 
225                 230                 235                 240 


Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val Glu His Arg 
                245                 250                 255     


Leu Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu 
            260                 265                 270         


Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Thr Thr Thr Gln 
        275                 280                 285             


Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr 
    290                 295                 300                 


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr 
305                 310                 315                 320 


Gly Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val 
                325                 330                 335     


Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu 
            340                 345                 350         


Trp Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
        355                 360             


<210>  6
<211>  363
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(363)
<223>  Q9WMX2[384-746], Genome polyprotein, Hepatitis C virus genotype 
       1b (isolate Con1)

<400>  6

Gly Thr Tyr Val Thr Gly Gly Thr Met Ala Lys Asn Thr Leu Gly Ile 
1               5                   10                  15      


Thr Ser Leu Phe Ser Pro Gly Ser Ser Gln Lys Ile Gln Leu Val Asn 
            20                  25                  30          


Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp 
        35                  40                  45              


Ser Leu Asn Thr Gly Phe Leu Ala Ala Leu Phe Tyr Val His Lys Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Ser Pro Ile Asp 
65                  70                  75                  80  


Ala Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Asn Glu Ser His Ser 
                85                  90                  95      


Ser Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly 
            100                 105                 110         


Ile Val Pro Ala Ala Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
        115                 120                 125             


Ser Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr 
    130                 135                 140                 


Ser Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg 
145                 150                 155                 160 


Pro Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
                165                 170                 175     


Phe Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Ile Gly 
            180                 185                 190         


Asn Lys Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu 
        195                 200                 205             


Ala Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys 
    210                 215                 220                 


Leu Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn 
225                 230                 235                 240 


Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg 
                245                 250                 255     


Leu Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Glu 
            260                 265                 270         


Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu 
        275                 280                 285             


Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr 
    290                 295                 300                 


Gly Leu Ile His Leu His Gln Asn Val Val Asp Val Gln Tyr Leu Tyr 
305                 310                 315                 320 


Gly Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Val 
                325                 330                 335     


Leu Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu 
            340                 345                 350         


Trp Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
        355                 360             


<210>  7
<211>  367
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(367)
<223>  P26660[384-750], Genome polyprotein, Hepatitis C virus genotype 
       2a (isolate HC-J6)

<400>  7

Gln Thr His Thr Val Gly Gly Ser Thr Ala His Asn Ala Arg Thr Leu 
1               5                   10                  15      


Thr Gly Met Phe Ser Leu Gly Ala Arg Gln Lys Ile Gln Leu Ile Asn 
            20                  25                  30          


Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp 
        35                  40                  45              


Ser Leu His Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr His Ser Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu 
65                  70                  75                  80  


Ala Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr 
                85                  90                  95      


Asn Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln 
            100                 105                 110         


Cys Gly Val Val Ser Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe 
        115                 120                 125             


Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro 
    130                 135                 140                 


Thr Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser 
145                 150                 155                 160 


Thr Arg Pro Pro Gln Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser 
                165                 170                 175     


Thr Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala 
            180                 185                 190         


Asp Phe Asn Ala Ser Met Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg 
        195                 200                 205             


Lys His Pro Asp Thr Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu 
    210                 215                 220                 


Thr Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro 
225                 230                 235                 240 


Cys Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly 
                245                 250                 255     


Val Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg 
            260                 265                 270         


Cys Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His 
        275                 280                 285             


Ser Thr Thr Glu Trp Ala Ile Leu Pro Cys Thr Tyr Ser Asp Leu Pro 
    290                 295                 300                 


Ala Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val 
305                 310                 315                 320 


Gln Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg 
                325                 330                 335     


Trp Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val 
            340                 345                 350         


Cys Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
        355                 360                 365         


<210>  8
<211>  369
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(369)
<223>  Q81495[384-752], Genome polyprotein, Hepatitis C virus genotype 
       3a (isolate k3a)

<400>  8

Ser Thr His Val Thr Ala Gly Gln Ala Ala Arg Asn Ala Tyr Gly Ile 
1               5                   10                  15      


Thr Ser Leu Phe Ser Val Gly Ala Lys Gln Asn Leu Gln Leu Ile Asn 
            20                  25                  30          


Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu 
        35                  40                  45              


Ser Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe 
    50                  55                  60                  


Asn Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr 
65                  70                  75                  80  


Phe Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly 
                85                  90                  95      


Pro Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys 
            100                 105                 110         


Gly Ile Val Pro Ala Leu Asn Val Cys Gly Pro Val Tyr Cys Phe Thr 
        115                 120                 125             


Pro Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Ala Pro Thr 
    130                 135                 140                 


Tyr Thr Trp Gly Ala Asn Lys Thr Asp Val Phe Leu Leu Glu Ser Leu 
145                 150                 155                 160 


Arg Pro Pro Ser Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
                165                 170                 175     


Gly Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Asp 
            180                 185                 190         


Gly Arg Asp Ala Gln Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys 
        195                 200                 205             


Phe Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro 
    210                 215                 220                 


Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His 
225                 230                 235                 240 


Tyr Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val 
                245                 250                 255     


Gly Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly 
            260                 265                 270         


Glu Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu 
        275                 280                 285             


Leu His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro 
    290                 295                 300                 


Met Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val 
305                 310                 315                 320 


Asp Val Gln Tyr Leu Tyr Gly Ile Gly Ser Gly Met Val Gly Trp Ala 
                325                 330                 335     


Leu Lys Trp Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Ala 
            340                 345                 350         


Arg Val Cys Val Ala Leu Trp Leu Ile Leu Thr Ile Ser Gln Ala Glu 
        355                 360                 365             


Ala 
    


<210>  9
<211>  370
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(370)
<223>  Q81487[385-754], Genome polyprotein, Hepatitis C virus genotype 
       3b (isolate Tr-Kj)

<400>  9

Thr Thr His Thr Thr Gly Gly Ser Ala Ala Gln Ala Thr Ala Gly Phe 
1               5                   10                  15      


Thr Ser Phe Phe Thr Arg Gly Pro Ser Gln Asn Leu Gln Leu Val Asn 
            20                  25                  30          


Ser Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp 
        35                  40                  45              


Ser Leu Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Met Ser Ser Cys Lys Pro Ile Thr 
65                  70                  75                  80  


Tyr Phe Asn Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Asn Gly 
                85                  90                  95      


Pro Ser Glu Asp Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
            100                 105                 110         


Asn Ile Thr Lys Pro Leu Asn Val Cys Gly Pro Val Tyr Cys Phe Thr 
        115                 120                 125             


Pro Ser Pro Val Val Val Gly Thr Thr Asp Ile Lys Gly Leu Pro Thr 
    130                 135                 140                 


Tyr Arg Phe Gly Val Asn Glu Ser Asp Val Phe Leu Leu Thr Ser Leu 
145                 150                 155                 160 


Arg Pro Pro Gln Gly Arg Trp Phe Gly Cys Val Trp Met Asn Ser Thr 
                165                 170                 175     


Gly Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly 
            180                 185                 190         


Met Lys Asp Ile Glu Ala Asn Gln Thr His Leu Lys Cys Pro Thr Asp 
        195                 200                 205             


Cys Phe Arg Lys His His Asp Ala Thr Phe Thr Arg Cys Gly Ser Gly 
    210                 215                 220                 


Pro Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp 
225                 230                 235                 240 


His Tyr Pro Cys Thr Val Asn Phe Ser Ile Phe Lys Val Arg Met Phe 
                245                 250                 255     


Val Gly Gly His Glu His Arg Phe Ser Ala Ala Cys Asn Trp Thr Arg 
            260                 265                 270         


Gly Glu Arg Cys Asp Leu Glu Asp Arg Asp Arg Ser Glu Gln Gln Pro 
        275                 280                 285             


Leu Leu His Ser Thr Thr Asp Ser Leu Ile Leu Pro Cys Ser Phe Thr 
    290                 295                 300                 


Pro Met Arg Arg Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile 
305                 310                 315                 320 


Val Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser Ala Val Val Gly Trp 
                325                 330                 335     


Ala Leu Lys Trp Glu Phe Val Val Leu Val Phe Leu Leu Leu Ala Asp 
            340                 345                 350         


Ala Arg Val Cys Val Ala Leu Trp Met Met Leu Leu Ile Ser Gln Ala 
        355                 360                 365             


Glu Ala 
    370 


<210>  10
<211>  367
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(367)
<223>  P26661[384-750], Genome polyprotein, Hepatitis C virus genotype 
       2b (isolate HC-J8)

<400>  10

Thr Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Ala Gly Phe 
1               5                   10                  15      


Ala Gly Leu Phe Thr Thr Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn 
            20                  25                  30          


Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp 
        35                  40                  45              


Ser Leu Gln Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr His Lys Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp 
65                  70                  75                  80  


Asp Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr 
                85                  90                  95      


Asn Asp Gly Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro 
            100                 105                 110         


Cys Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe 
        115                 120                 125             


Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro 
    130                 135                 140                 


Thr Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser 
145                 150                 155                 160 


Thr Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly 
                165                 170                 175     


Thr Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys 
            180                 185                 190         


Asp Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg 
        195                 200                 205             


Lys His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu 
    210                 215                 220                 


Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro 
225                 230                 235                 240 


Cys Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly 
                245                 250                 255     


Val Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg 
            260                 265                 270         


Cys Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His 
        275                 280                 285             


Ser Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro 
    290                 295                 300                 


Ala Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val 
305                 310                 315                 320 


Gln Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys 
                325                 330                 335     


Trp Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile 
            340                 345                 350         


Cys Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala 
        355                 360                 365         


<210>  11
<211>  363
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(363)
<223>  O39929[384-746], Genome polyprotein, Hepatitis C virus genotype 
       4a (isolate ED43)

<400>  11

Glu Thr His Val Ser Gly Ala Ala Val Gly Arg Ser Thr Ala Gly Leu 
1               5                   10                  15      


Ala Asn Leu Phe Ser Ser Gly Ser Lys Gln Asn Leu Gln Leu Ile Asn 
            20                  25                  30          


Ser Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp 
        35                  40                  45              


Ser Leu Asn Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr His Lys Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Ser Glu Arg Leu Ala Cys Cys Lys Ser Leu Asp 
65                  70                  75                  80  


Ser Tyr Gly Gln Gly Trp Gly Pro Leu Gly Val Ala Asn Ile Ser Gly 
                85                  90                  95      


Ser Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys 
            100                 105                 110         


Gly Ile Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
        115                 120                 125             


Pro Ser Pro Val Val Val Gly Thr Thr Asp His Val Gly Val Pro Thr 
    130                 135                 140                 


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
145                 150                 155                 160 


Arg Pro Pro His Gly Ala Trp Phe Gly Cys Val Trp Met Asn Ser Thr 
                165                 170                 175     


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Glu Val Asn Thr Asn 
            180                 185                 190         


Asn Gly Thr Trp His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu 
        195                 200                 205             


Thr Thr Tyr Ala Lys Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys 
    210                 215                 220                 


Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Phe Pro Cys Thr Ala Asn 
225                 230                 235                 240 


Phe Ser Val Phe Asn Ile Arg Thr Phe Val Gly Gly Ile Glu His Arg 
                245                 250                 255     


Met Gln Ala Ala Cys Asn Trp Thr Arg Gly Glu Val Cys Gly Leu Glu 
            260                 265                 270         


His Arg Asp Arg Val Glu Leu Ser Pro Leu Leu Leu Thr Thr Thr Ala 
        275                 280                 285             


Trp Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr 
    290                 295                 300                 


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr 
305                 310                 315                 320 


Gly Val Gly Ser Ala Val Val Ser Trp Ala Leu Lys Trp Glu Tyr Val 
                325                 330                 335     


Val Leu Ala Phe Leu Leu Leu Ala Asp Ala Arg Val Ser Ala Tyr Leu 
            340                 345                 350         


Trp Met Met Phe Met Val Ser Gln Val Glu Ala 
        355                 360             


<210>  12
<211>  364
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  MISC_FEATURE
<223>  O39928[384-747], Genome polyprotein, Hepatitis C virus genotype 
       5a (isolate EUH1480)

<400>  12

Arg Thr His Thr Val Gly Gly Thr Val Gly Gln Gly Leu Lys Ser Leu 
1               5                   10                  15      


Thr Ser Phe Phe Asn Pro Gly Pro Gln Arg Gln Leu Gln Phe Val Asn 
            20                  25                  30          


Thr Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp 
        35                  40                  45              


Ser Leu Gln Thr Gly Phe Ile Ala Gly Leu Met Tyr Ala His Lys Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Met Ser Ser Cys Arg Pro Leu Ala 
65                  70                  75                  80  


Ala Phe Asp Gln Gly Trp Gly Thr Ile Ser Tyr Ala Thr Ile Ser Gly 
                85                  90                  95      


Pro Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
            100                 105                 110         


Gly Val Val Pro Ala Arg Asp Val Cys Gly Pro Val Tyr Cys Phe Thr 
        115                 120                 125             


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Cys Pro Thr 
    130                 135                 140                 


Tyr Asn Trp Gly Ser Asn Glu Thr Asp Ile Leu Leu Leu Asn Asn Ile 
145                 150                 155                 160 


Arg Pro Pro Ala Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
                165                 170                 175     


Gly Phe Val Lys Asn Cys Gly Ala Pro Pro Cys Asn Leu Gly Pro Thr 
            180                 185                 190         


Gly Asn Asn Ser Leu Lys Cys Pro Thr Asp Cys Phe Arg Lys His Pro 
        195                 200                 205             


Asp Ala Thr Tyr Thr Arg Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg 
    210                 215                 220                 


Cys Leu Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val 
225                 230                 235                 240 


Asn Tyr Thr Ile Phe Lys Val Arg Met Phe Ile Gly Gly Leu Glu His 
                245                 250                 255     


Arg Leu Glu Ala Ala Cys Asn Trp Thr Tyr Gly Glu Arg Cys Asp Leu 
            260                 265                 270         


Glu Asp Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu His Thr Thr Thr 
        275                 280                 285             


Gln Trp Ala Ile Leu Pro Cys Ser Phe Thr Pro Thr Pro Ala Leu Ser 
    290                 295                 300                 


Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Thr Gln Tyr Leu 
305                 310                 315                 320 


Tyr Gly Leu Ser Ser Ser Ile Val Ser Trp Ala Val Lys Trp Glu Tyr 
                325                 330                 335     


Ile Met Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Thr Cys 
            340                 345                 350         


Leu Leu Ile Leu Leu Leu Ile Cys Gln Ala Glu Ala 
        355                 360                 


<210>  13
<211>  391
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(391)
<223>  Q5I2N3[384-751], Genome polyprotein, Hepatitis C virus genotype 
       6a (isolate 6a33)

<400>  13

Tyr Phe Gly Met Ala Gly Asn Trp Leu Lys Val Leu Ala Val Leu Phe 
1               5                   10                  15      


Leu Phe Ala Gly Val Glu Ala Thr Thr Thr Val Gly His Gly Val Ala 
            20                  25                  30          


Arg Thr Thr Ala Gly Ile Thr Gly Leu Phe Ser Pro Gly Ala Ser Gln 
        35                  40                  45              


Asn Leu Gln Leu Ile Lys Asn Gly Ser Ser Trp His Ile Asn Arg Thr 
    50                  55                  60                  


Ala Leu Asn Cys Asn Asp Ser Leu Gln Thr Gly Phe Leu Ala Ser Leu 
65                  70                  75                  80  


Phe Tyr Val Arg Lys Phe Asn Ser Ser Gly Cys Pro Glu Arg Met Ala 
                85                  90                  95      


Val Cys Lys Ser Leu Ala Asp Phe Arg Gln Gly Trp Gly Gln Ile Thr 
            100                 105                 110         


Tyr Lys Val Asn Ile Ser Gly Pro Ser Asp Asp Arg Pro Tyr Cys Trp 
        115                 120                 125             


His Tyr Ala Pro Arg Pro Cys Asp Val Val Pro Ala Ser Thr Val Cys 
    130                 135                 140                 


Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Ile Gly Thr Thr 
145                 150                 155                 160 


Asp Arg Arg Gly Asn Pro Thr Tyr Thr Trp Gly Glu Asn Glu Thr Asp 
                165                 170                 175     


Val Phe Met Leu Glu Ser Leu Arg Pro Pro Thr Gly Gly Trp Phe Gly 
            180                 185                 190         


Cys Thr Trp Met Asn Ser Thr Gly Phe Thr Lys Thr Cys Gly Ala Pro 
        195                 200                 205             


Pro Cys Gln Ile Ile Pro Gly Asp Tyr Asn Ser Ser Ala Asn Glu Leu 
    210                 215                 220                 


Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr Gln 
225                 230                 235                 240 


Arg Cys Gly Ser Gly Pro Trp Val Thr Pro Arg Cys Leu Val Asp Tyr 
                245                 250                 255     


Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe Thr Val His 
            260                 265                 270         


Lys Val Arg Met Phe Val Gly Gly Ile Glu His Arg Phe Asp Ala Ala 
        275                 280                 285             


Cys Asn Trp Thr Arg Gly Glu Arg Cys Glu Leu His Asp Arg Asp Arg 
    290                 295                 300                 


Ile Glu Met Ser Pro Leu Leu Phe Ser Thr Thr Gln Leu Ala Ile Leu 
305                 310                 315                 320 


Pro Cys Ser Phe Ser Thr Met Pro Ala Leu Ser Thr Gly Leu Ile His 
                325                 330                 335     


Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Val Ser Ser 
            340                 345                 350         


Ser Val Thr Ser Trp Val Val Lys Trp Glu Tyr Ile Val Leu Met Phe 
        355                 360                 365             


Leu Val Leu Ala Asp Ala Arg Ile Cys Thr Cys Leu Trp Leu Met Leu 
    370                 375                 380                 


Leu Ile Ser Asn Val Glu Ala 
385                 390     


<210>  14
<211>  368
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  MISC_FEATURE
<223>  O92529[384-751], Genome polyprotein, Hepatitis C virus genotype 
       6b (isolate Th580)

<400>  14

Thr Thr Thr Val Gly Arg Ala Ala Gly Arg Ser Ala Tyr Leu Phe Thr 
1               5                   10                  15      


Ser Ile Phe Ser Ser Gly Pro Asn Gln Lys Ile Gln Leu Ile Asn Thr 
            20                  25                  30          


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Ile Asp Ser 
        35                  40                  45              


Leu Gln Thr Gly Phe Leu Ser Ala Leu Phe Tyr Arg Ser Asn Phe Asn 
    50                  55                  60                  


Ser Thr Gly Cys Ser Glu Arg Leu Gly Ala Cys Lys Pro Leu Glu His 
65                  70                  75                  80  


Phe Gln Gln Gly Trp Gly Pro Ile Thr His Lys Ser Asn Ile Thr Gly 
                85                  90                  95      


Pro Ser Glu Asp Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Glu Cys 
            100                 105                 110         


Ser Val Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
        115                 120                 125             


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Asn Pro Thr 
    130                 135                 140                 


Tyr Asn Trp Gly Glu Asn Glu Thr Asp Val Phe Met Leu Glu Ser Leu 
145                 150                 155                 160 


Arg Pro Pro Gln Gly Gly Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
                165                 170                 175     


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Gln Leu Ile Pro Gly 
            180                 185                 190         


Asp Tyr Asn Ser Ser Ser Asn Gln Leu Leu Cys Pro Thr Asp Cys Phe 
        195                 200                 205             


Arg Lys His Pro Glu Ala Thr Tyr Gln Lys Cys Gly Ser Gly Pro Trp 
    210                 215                 220                 


Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
225                 230                 235                 240 


Pro Cys Thr Val Asn Tyr Thr Ile His Lys Val Arg Met Phe Ile Gly 
                245                 250                 255     


Gly Val Glu His Arg Phe Asp Ala Ala Cys Asn Trp Thr Arg Gly Asp 
            260                 265                 270         


Arg Cys Asp Leu Tyr Asp Arg Asp Arg Ile Glu Met Ser Pro Leu Leu 
        275                 280                 285             


Phe Ser Thr Thr Gln Leu Ala Ile Leu Pro Cys Ser Phe Thr Thr Met 
    290                 295                 300                 


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
305                 310                 315                 320 


Val Gln Tyr Leu Tyr Gly Val Ser Ser Ser Ile Val Ser Trp Ala Val 
                325                 330                 335     


Lys Trp Glu Tyr Val Val Leu Met Phe Leu Val Leu Ala Asp Ala Arg 
            340                 345                 350         


Ile Cys Thr Cys Leu Trp Leu Met Leu Leu Val Gly Lys Val Glu Ala 
        355                 360                 365             


