                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, as represented by the 
       Secretary, Department of Health and Human Services
       Centre for the AIDS Programme of Research in South Africa
       University of the Witwatersrand, Johannesburg
       National Health Laboratory Service
       The Trustees of Columbia University in the City of New York
 
<120>  Broadly Neutralising Monoclonal Antibodies against HIV-1 V1V2 
       Region

<130>  PA161588/P

<160>  193   

<170>  PatentIn version 3.5

<210>  1
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Unmutated common ancestor

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Gly Glu Ser Glu Asn Glu Glu Trp Ala Thr Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Ser Ile Gly Tyr Pro Gly Gln Asp Pro Arg Gly Val Val 
        115                 120                 125             


Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  2
<211>  217
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Unmutated common ancestor

<400>  2

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Gly Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  3
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Unmutated common ancestor

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Gly Glu Ser Glu Asn Glu Glu Trp Ala Thr Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Ser Ile Gly Tyr Pro Gly Gln Asp Pro Arg Gly Val Val 
        115                 120                 125             


Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  4
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Unmutated common ancestor

<400>  4

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Gly Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  5
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  5

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Ser Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Gly Glu Asn Lys Asn Asp Glu Trp Ala Thr Asp Tyr 
            100                 105                 110         


Tyr Asp Leu Ser Ile Ala Tyr Pro Val Gln Asp Pro Arg Ala Val Val 
        115                 120                 125             


Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  6
<211>  217
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  6

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Asn Asn Glu Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Leu 
                85                  90                  95      


Ser Ala Gly Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  7
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Ser Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Gly Glu Asn Lys Asn Asp Glu Trp Ala Thr Asp Tyr 
            100                 105                 110         


Tyr Asp Leu Ser Ile Ala Tyr Pro Val Gln Asp Pro Arg Ala Val Val 
        115                 120                 125             


Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  8
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  8

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Asn Asn Glu Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Leu 
                85                  90                  95      


Ser Ala Gly Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  9
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Asp Gly Ser Asn Lys Asn Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Val Gly Glu Tyr Lys Ser Asp Glu Trp Ala Thr Asp Tyr 
            100                 105                 110         


Tyr Asp Leu Ser Ile Ala Tyr Pro Ile Gln Asp Pro Arg Ala Met Val 
        115                 120                 125             


Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  10
<211>  217
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  10

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Thr Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Leu Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Leu 
                85                  90                  95      


Ser Ala Gly Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  11
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  11

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Asp Gly Ser Asn Lys Asn Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Val Gly Glu Tyr Lys Ser Asp Glu Trp Ala Thr Asp Tyr 
            100                 105                 110         


Tyr Asp Leu Ser Ile Ala Tyr Pro Ile Gln Asp Pro Arg Ala Met Val 
        115                 120                 125             


Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  12
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  12

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Thr Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Leu Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Leu 
                85                  90                  95      


Ser Ala Gly Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  13
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  13

Glu Val Gln Val Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Asp Gly Ser Asn Lys Asn Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Val Gly Asp Tyr Lys Ser Asp Glu Trp Gly Thr Glu Tyr 
            100                 105                 110         


Tyr Asp Ile Ser Ile Ser Tyr Pro Ile Gln Asp Pro Arg Ala Met Val 
        115                 120                 125             


Gly Ala Phe Asp Leu Trp Gly Gln Gly Thr Met Val Thr Val Ser Pro 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  14
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Thr Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Arg Leu Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Asn Asp Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Leu 
                85                  90                  95      


Ser Gly Gly Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asp Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  15
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Val Gln Val Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Asp Gly Ser Asn Lys Asn Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Val Gly Asp Tyr Lys Ser Asp Glu Trp Gly Thr Glu Tyr 
            100                 105                 110         


Tyr Asp Ile Ser Ile Ser Tyr Pro Ile Gln Asp Pro Arg Ala Met Val 
        115                 120                 125             


Gly Ala Phe Asp Leu Trp Gly Gln Gly Thr Met Val Thr Val Ser Pro 
    130                 135                 140                 


<210>  16
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Thr Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Arg Leu Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Lys Asn Asp Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Leu 
                85                  90                  95      


Ser Gly Gly Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  17
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gln Phe Ser Phe Gly Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Phe Ala Gly Thr Lys Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp Ile Arg Glu Tyr Glu Cys Glu Tyr Trp Thr Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Arg Pro Gln Pro Cys Ile Asp Ser Arg Gly Val Val 
        115                 120                 125             


Gly Thr Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  18
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Lys 
            20                  25                  30          


Asp Val Ser Trp Tyr Gln Gln Ile Pro Ala Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Gly Arg Val 
                85                  90                  95      


Ser Val Ile Gly Thr Gly Thr Asn Val Ile Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Asp Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  19
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gln Phe Ser Phe Gly Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Phe Ala Gly Thr Lys Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp Ile Arg Glu Tyr Glu Cys Glu Tyr Trp Thr Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Arg Pro Gln Pro Cys Ile Asp Ser Arg Gly Val Val 
        115                 120                 125             


Gly Thr Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  20
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Lys 
            20                  25                  30          


Asp Val Ser Trp Tyr Gln Gln Ile Pro Ala Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Gly Arg Val 
                85                  90                  95      


Ser Val Ile Gly Thr Gly Thr Asn Val Ile Val Leu 
            100                 105             


<210>  21
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Ser Phe Asn Arg Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asp Gly Thr Asp Lys Tyr His Ala Asp Lys Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Lys Gln Leu Pro Cys Arg Lys Ser Arg Gly Val Ala 
        115                 120                 125             


Gly Ile Phe Asp Gly Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  22
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Arg Pro Gly Thr Ala Pro Lys Ile Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Ser Glu Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Ala Asp Glu Ala Glu Tyr Tyr Cys Ala Thr Trp Ser Ala Ser Leu 
                85                  90                  95      


Ser Ser Ala Arg Val Phe Gly Thr Gly Thr Arg Ile Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asp Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  23
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Ser Phe Asn Arg Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asp Gly Thr Asp Lys Tyr His Ala Asp Lys Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Lys Gln Leu Pro Cys Arg Lys Ser Arg Gly Val Ala 
        115                 120                 125             


Gly Ile Phe Asp Gly Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  24
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Arg Pro Gly Thr Ala Pro Lys Ile Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Ser Glu Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Ala Asp Glu Ala Glu Tyr Tyr Cys Ala Thr Trp Ser Ala Ser Leu 
                85                  90                  95      


Ser Ser Ala Arg Val Phe Gly Thr Gly Thr Arg Ile Thr Val Leu 
            100                 105                 110     


<210>  25
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gln Phe Ser Phe Asn Arg Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asp Gly Thr Asp Lys Tyr His Ala Asp Lys Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Lys Gln Leu Pro Cys Arg Lys Ser Arg Gly Val Ala 
        115                 120                 125             


Gly Ile Phe Asp Lys Trp Gly Gln Gly Thr Met Val Ile Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  26
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Arg Pro Gly Thr Ala Pro Ser Leu Leu 
        35                  40                  45              


Ile Tyr Glu Thr Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Ala Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Ala Ala Ser Leu 
                85                  90                  95      


Thr Ser Ala Arg Val Phe Gly Thr Gly Thr Lys Val Ile Val Ser Gly 
            100                 105                 110         


Gln Pro Lys Ala Asp Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  27
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gln Phe Ser Phe Asn Arg Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asp Gly Thr Asp Lys Tyr His Ala Asp Lys Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Lys Gln Leu Pro Cys Arg Lys Ser Arg Gly Val Ala 
        115                 120                 125             


Gly Ile Phe Asp Lys Trp Gly Gln Gly Thr Met Val Ile Val Ser Ser 
    130                 135                 140                 


<210>  28
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Arg Pro Gly Thr Ala Pro Ser Leu Leu 
        35                  40                  45              


Ile Tyr Glu Thr Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Ala Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Ala Ala Ser Leu 
                85                  90                  95      


Thr Ser Ala Arg Val Phe Gly Thr Gly Thr Lys Val Ile Val Ser 
            100                 105                 110     


<210>  29
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Gly Ile Ser Phe Ala Gly Thr Lys Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Val Ser Arg Asp Ile Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Arg Tyr Tyr Glu Cys Glu Glu Trp Ala Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Arg Glu Gln Pro Cys Leu Asp Pro Arg Gly Val Val 
        115                 120                 125             


Gly Ile Phe Asp Leu Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  30
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Asn Ile Gly Asn Asn Tyr Val Ser 
            20                  25                  30          


Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Glu 
        35                  40                  45              


Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys 
    50                  55                  60                  


Ser Gly Thr Ser Ala Thr Leu Val Ile Thr Gly Leu Gln Thr Gly Asp 
65                  70                  75                  80  


Glu Ala Asp Phe Tyr Cys Gly Thr Trp Gly Gly Ser Leu Arg Thr Gly 
                85                  90                  95      


Gly Val Leu Gly Thr Gly Thr Arg Val Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Asp Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  31
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Gly Ile Ser Phe Ala Gly Thr Lys Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Val Ser Arg Asp Ile Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Arg Tyr Tyr Glu Cys Glu Glu Trp Ala Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Arg Glu Gln Pro Cys Leu Asp Pro Arg Gly Val Val 
        115                 120                 125             


Gly Ile Phe Asp Leu Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  32
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Asn Ile Gly Asn Asn Tyr Val Ser 
            20                  25                  30          


Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Glu 
        35                  40                  45              


Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys 
    50                  55                  60                  


Ser Gly Thr Ser Ala Thr Leu Val Ile Thr Gly Leu Gln Thr Gly Asp 
65                  70                  75                  80  


Glu Ala Asp Phe Tyr Cys Gly Thr Trp Gly Gly Ser Leu Arg Thr Gly 
                85                  90                  95      


Gly Val Leu Gly Thr Gly Thr Arg Val Thr Val Leu 
            100                 105             


<210>  33
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Val Gln Leu Ile Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Ser Phe Asn Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Ser Phe Ala Gly Ile Lys Lys Tyr Tyr Gly Thr Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Asn Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Arg Glu Leu Glu Cys Glu Glu Trp Thr Leu Tyr Asn 
            100                 105                 110         


Tyr Tyr Asp Phe Gly Ser Arg Gly Pro Cys Val Asp Pro Arg Gly Val 
        115                 120                 125             


Ala Gly Ser Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  34
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  34

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Lys Ile Gly Gln Asn 
            20                  25                  30          


Ser Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asp Arg Arg Pro Ser Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Glu Tyr Tyr Cys Glu Thr Trp Asp Gly Ser Gly 
                85                  90                  95      


Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Asp Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  35
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  35

Glu Val Gln Leu Ile Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Ser Phe Asn Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Ser Phe Ala Gly Ile Lys Lys Tyr Tyr Gly Thr Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Asn Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Arg Glu Leu Glu Cys Glu Glu Trp Thr Leu Tyr Asn 
            100                 105                 110         


Tyr Tyr Asp Phe Gly Ser Arg Gly Pro Cys Val Asp Pro Arg Gly Val 
        115                 120                 125             


Ala Gly Ser Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser 
145 


<210>  36
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Lys Ile Gly Gln Asn 
            20                  25                  30          


Ser Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asp Arg Arg Pro Ser Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Glu Tyr Tyr Cys Glu Thr Trp Asp Gly Ser Gly 
                85                  90                  95      


Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  37
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gln Phe Ser Phe Asn Arg Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Ser Phe Asp Gly Thr Asp Arg Tyr His Ala Asp Asn Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Lys Lys Leu Pro Cys Arg Lys Ser Arg Gly Val Ala 
        115                 120                 125             


Gly Val Phe Asp Lys Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  38
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Asn Val Thr Ile Ser Cys Ser Gly Ser Gly Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Arg Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ser Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Tyr Tyr Tyr Cys Ala Thr Trp Ala Ala Arg Leu 
                85                  90                  95      


Asn Ser Ala Arg Val Phe Gly Thr Gly Thr Met Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asp Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  39
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gln Phe Ser Phe Asn Arg Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Ser Phe Asp Gly Thr Asp Arg Tyr His Ala Asp Asn Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Lys Lys Leu Pro Cys Arg Lys Ser Arg Gly Val Ala 
        115                 120                 125             


Gly Val Phe Asp Lys Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  40
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Asn Val Thr Ile Ser Cys Ser Gly Ser Gly Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Arg Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ser Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Tyr Tyr Tyr Cys Ala Thr Trp Ala Ala Arg Leu 
                85                  90                  95      


Asn Ser Ala Arg Val Phe Gly Thr Gly Thr Met Val Thr Val Leu 
            100                 105                 110     


<210>  41
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gln Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Ser Asn Asp Gly Thr Lys Lys Tyr His Gly Asp Ser Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Arg Asp Gln Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Arg Glu Leu Pro Cys Arg Lys Phe Arg Gly Leu Gly 
        115                 120                 125             


Leu Ala Gly Ile Phe Asp Ile Trp Gly His Gly Thr Met Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  42
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Asn Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Leu Tyr Glu Thr Tyr Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Thr Val Trp Gly Val Arg Lys 
                85                  90                  95      


Gly Val Gly Ala Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asp Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  43
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gln Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Ser Asn Asp Gly Thr Lys Lys Tyr His Gly Asp Ser Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Arg Asp Gln Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Arg Glu Leu Pro Cys Arg Lys Phe Arg Gly Leu Gly 
        115                 120                 125             


Leu Ala Gly Ile Phe Asp Ile Trp Gly His Gly Thr Met Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  44
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Asn Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Leu Tyr Glu Thr Tyr Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Thr Val Trp Gly Val Arg Lys 
                85                  90                  95      


Gly Val Gly Ala Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  45
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gln Phe Asn Phe Ala Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asn Asp Gly Thr Lys Lys Tyr His Glu Glu Ser Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ile Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Val Lys Asp Gln Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Arg Glu Leu Pro Cys Arg Lys Ser Arg Gly Leu Gly 
        115                 120                 125             


Leu Ala Gly Ile Phe Asp Met Trp Gly His Gly Thr Met Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  46
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  46

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Asn Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Trp Cys Ala Val Trp Gly Val Arg Arg 
                85                  90                  95      


Gly Ala Gly Ala Val Phe Gly Ala Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asp Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  47
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gln Phe Asn Phe Ala Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asn Asp Gly Thr Lys Lys Tyr His Glu Glu Ser Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ile Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Val Lys Asp Gln Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Arg Glu Leu Pro Cys Arg Lys Ser Arg Gly Leu Gly 
        115                 120                 125             


Leu Ala Gly Ile Phe Asp Met Trp Gly His Gly Thr Met Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  48
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Asn Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Trp Cys Ala Val Trp Gly Val Arg Arg 
                85                  90                  95      


Gly Ala Gly Ala Val Phe Gly Ala Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  49
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  49

Gln Ala Ile Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gln Phe Thr Phe Ser Gly His 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Phe Ala Gly Thr Lys Met Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Met Arg Glu Tyr Glu Cys Glu Tyr Trp Thr Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Arg Pro Gln Pro Cys Ile Asp Arg Arg Gly Val Val 
        115                 120                 125             


Gly Ile Phe Asp Met Trp Gly Gln Gly Thr Met Val Thr Val Ser Thr 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  50
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  50

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Thr Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Val Arg Pro 
                85                  90                  95      


Asn Arg Gly Ala Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asp Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  51
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  51

Gln Ala Ile Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gln Phe Thr Phe Ser Gly His 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Phe Ala Gly Thr Lys Met Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Met Arg Glu Tyr Glu Cys Glu Tyr Trp Thr Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Arg Pro Gln Pro Cys Ile Asp Arg Arg Gly Val Val 
        115                 120                 125             


Gly Ile Phe Asp Met Trp Gly Gln Gly Thr Met Val Thr Val Ser Thr 
    130                 135                 140                 


<210>  52
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Thr Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Val Arg Pro 
                85                  90                  95      


Asn Arg Gly Ala Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  53
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Pro Pro Gly Lys 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Arg Phe Thr Phe Ser Ala Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Phe Ala Gly Ile Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Met Asn Gly Leu Arg Gly Glu Asp Thr Gly Leu Tyr His Cys Val 
                85                  90                  95      


Lys Asp Met Arg Glu Leu Glu Cys Glu Glu Trp Ala Ser Asp Tyr Tyr 
            100                 105                 110         


Asp Phe Gly Lys Pro Gln Pro Cys Leu Asp Arg Arg Gly Val Ser Gly 
        115                 120                 125             


Ile Ser Ala Trp Trp Gly Pro Gly Thr Met Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  54
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  54

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Asn Val Thr Ile Ser Cys Ser Gly Pro Pro Ser His Ile Glu Lys Asn 
            20                  25                  30          


Asp Val Ser Trp Tyr Gln Arg Leu Pro Gly Met Ala Pro Lys Met Val 
        35                  40                  45              


Ile Tyr Glu Ser Lys Arg Arg Pro Leu Gly Ile Pro Val Arg Phe Ser 
    50                  55                  60                  


Ala Ser Arg Ser Gly Ser Ser Ala Thr Leu Val Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Ala Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Gly Arg Met 
                85                  90                  95      


Asn Phe Gly Thr Gly Thr Thr Val Ser Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Asp Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  55
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Pro Pro Gly Lys 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Arg Phe Thr Phe Ser Ala Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Phe Ala Gly Ile Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Met Asn Gly Leu Arg Gly Glu Asp Thr Gly Leu Tyr His Cys Val 
                85                  90                  95      


Lys Asp Met Arg Glu Leu Glu Cys Glu Glu Trp Ala Ser Asp Tyr Tyr 
            100                 105                 110         


Asp Phe Gly Lys Pro Gln Pro Cys Leu Asp Arg Arg Gly Val Ser Gly 
        115                 120                 125             


Ile Ser Ala Trp Trp Gly Pro Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140             


<210>  56
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Asn Val Thr Ile Ser Cys Ser Gly Pro Pro Ser His Ile Glu Lys Asn 
            20                  25                  30          


Asp Val Ser Trp Tyr Gln Arg Leu Pro Gly Met Ala Pro Lys Met Val 
        35                  40                  45              


Ile Tyr Glu Ser Lys Arg Arg Pro Leu Gly Ile Pro Val Arg Phe Ser 
    50                  55                  60                  


Ala Ser Arg Ser Gly Ser Ser Ala Thr Leu Val Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Ala Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Gly Arg Met 
                85                  90                  95      


Asn Phe Gly Thr Gly Thr Thr Val Ser Val Leu 
            100                 105         


<210>  57
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  57

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Tyr Phe Glu Phe Gly Arg Tyr 
            20                  25                  30          


Gly Phe His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Phe Ala Gly Arg Asp Tyr Tyr His Ser Pro Ser Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ile Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Leu Arg Glu Ser Glu Cys Glu Glu Trp Glu Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Lys Lys Gly Pro Cys Val Lys Pro Arg Gly Val Ala 
        115                 120                 125             


Gly Gly Leu Asp Leu Trp Gly Gln Gly Thr Met Val Ile Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  58
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  58

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Thr Ala Pro Gly Gln 
1               5                   10                  15      


Thr Val Thr Val Ser Cys Ser Gly Gly Thr Ser Asn Thr Gly Asn Asn 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Leu Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ala Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Gly Asp Tyr Tyr Cys Ala Thr Trp Ser Gly Ser Leu 
                85                  90                  95      


Asn Ile Gly Thr Gly Thr Lys Val Ser Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Asp Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  59
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  59

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Tyr Phe Glu Phe Gly Arg Tyr 
            20                  25                  30          


Gly Phe His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Phe Ala Gly Arg Asp Tyr Tyr His Ser Pro Ser Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ile Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Leu Arg Glu Ser Glu Cys Glu Glu Trp Glu Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Lys Lys Gly Pro Cys Val Lys Pro Arg Gly Val Ala 
        115                 120                 125             


Gly Gly Leu Asp Leu Trp Gly Gln Gly Thr Met Val Ile Val Ser Ser 
    130                 135                 140                 


<210>  60
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  60

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Thr Ala Pro Gly Gln 
1               5                   10                  15      


Thr Val Thr Val Ser Cys Ser Gly Gly Thr Ser Asn Thr Gly Asn Asn 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Leu Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ala Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Gly Asp Tyr Tyr Cys Ala Thr Trp Ser Gly Ser Leu 
                85                  90                  95      


Asn Ile Gly Thr Gly Thr Lys Val Ser Val Leu 
            100                 105         


<210>  61
<211>  1425
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Unmutated common ancestor

<400>  61
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagatctg      300

ggagaaagcg aaaatgaaga gtgggcgacg gattattacg atttttcgat tggttaccct      360

ggccaagacc cacggggcgt ggttggagct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccc      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      720

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      780

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1080

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aatga                     1425


<210>  62
<211>  654
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Unmutated common ancestor

<400>  62
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatctat gaaaataata agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata gcagcctgag tgctggcggt      300

gtcttcggaa ctgggaccaa agtcaccgtc ctaggtcagc ccaaggccaa ccccactgtc      360

actctgttcc cgccctcgag tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctacctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            654


<210>  63
<211>  432
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Unmutated common ancestor

<400>  63
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagatctg      300

ggagaaagcg aaaatgaaga gtgggcgacg gattattacg atttttcgat tggttaccct      360

ggccaagacc cacggggcgt ggttggagct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt ca                                                          432


<210>  64
<211>  333
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Unmutated common ancestor

<400>  64
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatctat gaaaataata agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata gcagcctgag tgctggcggt      300

gtcttcggaa ctgggaccaa agtcaccgtc cta                                   333


<210>  65
<211>  1425
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  65
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aactatgcca tggactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatctg atggaagtaa taaaaactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagtctgag agctgaggac acggctgtgt attactgtgc gaaagatctg      300

ggagaaaaca aaaatgatga gtgggcgacg gattattatg atttgtcgat tgcttaccct      360

gtccaagacc cacgggccgt ggttggagct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccc      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      720

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      780

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1080

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aatga                     1425


<210>  66
<211>  654
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  66
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatctat aaaaataatg agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata ccagcctgag tgctggcggt      300

gtcttcggaa ctgggaccaa ggtcaccgtc ctaggtcagc ccaaggccaa ccccactgtc      360

actctgttcc cgccctcgag tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctacctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            654


<210>  67
<211>  432
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  67
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aactatgcca tggactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatctg atggaagtaa taaaaactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagtctgag agctgaggac acggctgtgt attactgtgc gaaagatctg      300

ggagaaaaca aaaatgatga gtgggcgacg gattattatg atttgtcgat tgcttaccct      360

gtccaagacc cacgggccgt ggttggagct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt ca                                                          432


<210>  68
<211>  333
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  68
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatctat aaaaataatg agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata ccagcctgag tgctggcggt      300

gtcttcggaa ctgggaccaa ggtcaccgtc cta                                   333


<210>  69
<211>  1425
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  69
caagtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt cactttcagt aactttgcca tgggctgggt ccgccaggct      120

ccgggcaagg gtctggagtg ggtggcgttt atatcatctg atggaagtaa taaaaactat      180

ggagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgttc      240

ctgcaaatga acagtctgag agctgaggac acggctttgt attactgtgc gaaagatgtg      300

ggagaataca aaagtgatga gtgggcgacg gattattatg atctttcgat tgcttaccct      360

attcaagacc cacgggccat ggttggagct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccc      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      720

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      780

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1080

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aatga                     1425


<210>  70
<211>  654
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  70
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caccattggg aataattatg tatcctggta ccagctactc      120

ccaggaacag cccccaaact cctcatctat aaaaatgata agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata ccagcctgag tgctggcggt      300

gtcttcggaa ctgggaccaa ggtcaccgtc ctaggtcagc ccaaggccaa ccccactgtc      360

actctgttcc cgccctcgag tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctacctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            654


<210>  71
<211>  432
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  71
caagtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt cactttcagt aactttgcca tgggctgggt ccgccaggct      120

ccgggcaagg gtctggagtg ggtggcgttt atatcatctg atggaagtaa taaaaactat      180

ggagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgttc      240

ctgcaaatga acagtctgag agctgaggac acggctttgt attactgtgc gaaagatgtg      300

ggagaataca aaagtgatga gtgggcgacg gattattatg atctttcgat tgcttaccct      360

attcaagacc cacgggccat ggttggagct tttgatatct ggggccaagg gacaatggtc      420

accgtctctt ca                                                          432


<210>  72
<211>  333
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Inferred intermediate sequence

<400>  72
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caccattggg aataattatg tatcctggta ccagctactc      120

ccaggaacag cccccaaact cctcatctat aaaaatgata agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata ccagcctgag tgctggcggt      300

gtcttcggaa ctgggaccaa ggtcaccgtc cta                                   333


<210>  73
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  73
gaagtgcagg tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtacag cctctggatt cactttcagc aactttgcca tgggctgggt ccgccaggct      120

ccgggcaagg gtctggagtg ggtggccttt atatcatctg atggaagtaa taaaaactat      180

ggagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacggtgttc      240

ctgcaaatga acagtctgag agttgaggac acggctttgt attactgtgc gaaagatgtg      300

ggagactaca aaagtgatga gtgggggacg gaatattatg atatttcgat ttcttaccct      360

attcaagacc cacgggccat ggttggagct tttgatctct ggggccaagg gacaatggtc      420

accgtctctc cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccc      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      720

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      780

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1080

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aatga                     1425


<210>  74
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  74
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caccattggg aataattatg tctcctggta ccggctactc      120

ccaggaacag cccccaaact cctcatctat aaaaatgata accgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcag cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata ccagcctgag tggtggcggt      300

gtcttcggaa ctgggaccaa ggtcaccgtc ctaggtcagc ccaaggccaa ccccactgtc      360

actctgttcc cgccctcgag tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctacctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            654


<210>  75
<211>  432
<212>  DNA
<213>  Homo sapiens

<400>  75
gaagtgcagg tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtacag cctctggatt cactttcagc aactttgcca tgggctgggt ccgccaggct      120

ccgggcaagg gtctggagtg ggtggccttt atatcatctg atggaagtaa taaaaactat      180

ggagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacggtgttc      240

ctgcaaatga acagtctgag agttgaggac acggctttgt attactgtgc gaaagatgtg      300

ggagactaca aaagtgatga gtgggggacg gaatattatg atatttcgat ttcttaccct      360

attcaagacc cacgggccat ggttggagct tttgatctct ggggccaagg gacaatggtc      420

accgtctctc ca                                                          432


<210>  76
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  76
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caccattggg aataattatg tctcctggta ccggctactc      120

ccaggaacag cccccaaact cctcatctat aaaaatgata accgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcag cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata ccagcctgag tggtggcggt      300

gtcttcggaa ctgggaccaa ggtcaccgtc cta                                   333


<210>  77
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  77
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctcaatt cagctttggt aactatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcagcc atttcatttg ctggaactaa gacaaactat      180

gcagattccg tgaagggccg attcaccatc tccagagaca attccaagaa cacggtctat      240

ctgcaaatga acagcctgcg cgctgaggac acggctctat atttctgtgc gaaagatatc      300

cgagaatacg aatgtgaata ttggacgtcg gattattacg attttgggag accgcaacct      360

tgtatagact cacggggggt ggttggaact tttgatgtct ggggccaagg gacaatggtc      420

accgtctctt cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccc      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      720

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      780

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1080

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aatga                     1425


<210>  78
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  78
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcaattc caacattggg aataaagatg tatcctggta ccaacagatc      120

ccagcaacag cccccaaact cctcatctat gaaaataaca agcgaccctc agggatttct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

actggggacg aggccgatta ttactgcgca acatgggatg gcagagtgag tgtcatcgga      300

actgggacca atgtcatcgt cctaggtcag cccaaggcca accccactgt cactctgttc      360

ccgccctcga gtgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctacctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt catag                      645


<210>  79
<211>  432
<212>  DNA
<213>  Homo sapiens

<400>  79
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctcaatt cagctttggt aactatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcagcc atttcatttg ctggaactaa gacaaactat      180

gcagattccg tgaagggccg attcaccatc tccagagaca attccaagaa cacggtctat      240

ctgcaaatga acagcctgcg cgctgaggac acggctctat atttctgtgc gaaagatatc      300

cgagaatacg aatgtgaata ttggacgtcg gattattacg attttgggag accgcaacct      360

tgtatagact cacggggggt ggttggaact tttgatgtct ggggccaagg gacaatggtc      420

accgtctctt ca                                                          432


<210>  80
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  80
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcaattc caacattggg aataaagatg tatcctggta ccaacagatc      120

ccagcaacag cccccaaact cctcatctat gaaaataaca agcgaccctc agggatttct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

actggggacg aggccgatta ttactgcgca acatgggatg gcagagtgag tgtcatcgga      300

actgggacca atgtcatcgt ccta                                             324


<210>  81
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  81
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaagtc cctgagactc       60

tcctgtgcag cctctcgatt cagttttaat agatatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagcc atatcatatg atggaactga taaatatcat      180

gcagataaag tgtggggccg cttcaccatc tccagagaca attccaagaa cacactgtat      240

ctgcaaatga acagcctgcg agctgaggac acggctctct attactgtgc gaaagatttg      300

cgagaggacg aatgtgaaga gtggtggtcg gattattacg attttgggaa acagctccct      360

tgccgaaagt cacggggcgt ggctggaatt tttgatggct ggggccaagg gacaatggtc      420

accgtctctt cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccc      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      720

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      780

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1080

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aatga                     1425


<210>  82
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  82
cagtctgtgc tgactcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggc aataattttg tatcctggta ccagcagcgc      120

ccaggaacag cccccaagat cctcatttat gaaaataaca agcgaccctc agagactcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggcctccag      240

actgcggacg aggccgaata ttactgcgcc acatggtctg ccagcctgag ctccgcgcgt      300

gtcttcggaa ctgggaccag gatcaccgtc ctaggtcagc ccaaggccaa ccccactgtc      360

actctgttcc cgccctcgag tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctacctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            654


<210>  83
<211>  432
<212>  DNA
<213>  Homo sapiens

<400>  83
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaagtc cctgagactc       60

tcctgtgcag cctctcgatt cagttttaat agatatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagcc atatcatatg atggaactga taaatatcat      180

gcagataaag tgtggggccg cttcaccatc tccagagaca attccaagaa cacactgtat      240

ctgcaaatga acagcctgcg agctgaggac acggctctct attactgtgc gaaagatttg      300

cgagaggacg aatgtgaaga gtggtggtcg gattattacg attttgggaa acagctccct      360

tgccgaaagt cacggggcgt ggctggaatt tttgatggct ggggccaagg gacaatggtc      420

accgtctctt ca                                                          432


<210>  84
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  84
cagtctgtgc tgactcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggc aataattttg tatcctggta ccagcagcgc      120

ccaggaacag cccccaagat cctcatttat gaaaataaca agcgaccctc agagactcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggcctccag      240

actgcggacg aggccgaata ttactgcgcc acatggtctg ccagcctgag ctccgcgcgt      300

gtcttcggaa ctgggaccag gatcaccgtc cta                                   333


<210>  85
<211>  1470
<212>  DNA
<213>  Homo sapiens

<400>  85
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaagtc cctgagactc       60

tcatgtgcag cctctcaatt cagttttaat agatatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagct atatcatatg atggaactga taaataccac      180

gctgataaag tgtggggccg cttcaccatc tccagagaca attccaagaa cacactgtat      240

ctgcaaatga acagcctgcg agctgaggac acggctctgt attactgtgc gaaagatttg      300

cgagaagacg agtgtgaaga gtggtggtcg gattattacg attttgggaa acaactccct      360

tgccgaaagt cacggggcgt ggctggaatt tttgataagt ggggccaagg gacaatggtc      420

atcgtctctt cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccgcg      480

tcgaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      540

acagcggccc tgggctgcct ggtcaaggac tacttccccg aacccgtgac ggtgtcgtgg      600

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      660

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      720

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      780

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      840

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      900

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      960

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc     1020

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     1080

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1140

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1200

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1260

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1320

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1380

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1440

aagagcctct ccctgtctcc gggtaaatga                                      1470


<210>  86
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  86
cagcctgtgc tgactcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggc aataattttg tttcctggta ccagcagcgg      120

ccaggaacag cccccagcct cctcatttat gaaactaaca agcgaccctc aggaattcct      180

gaccgattct ctggctccaa gtctgccacg tcagccaccc tggccatcac cgggctccag      240

actggggacg aggccgatta ttactgcgcc acgtgggctg ccagcctgac ttccgcgcgt      300

gtcttcggaa ctgggaccaa ggtaatcgtc tcaggtcagc ccaaggccaa ccccactgtc      360

actctgttcc cgccctcgag tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctacctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            654


<210>  87
<211>  477
<212>  DNA
<213>  Homo sapiens

<400>  87
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaagtc cctgagactc       60

tcatgtgcag cctctcaatt cagttttaat agatatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagct atatcatatg atggaactga taaataccac      180

gctgataaag tgtggggccg cttcaccatc tccagagaca attccaagaa cacactgtat      240

ctgcaaatga acagcctgcg agctgaggac acggctctgt attactgtgc gaaagatttg      300

cgagaagacg agtgtgaaga gtggtggtcg gattattacg attttgggaa acaactccct      360

tgccgaaagt cacggggcgt ggctggaatt tttgataagt ggggccaagg gacaatggtc      420

atcgtctctt cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctcc         477


<210>  88
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  88
cagcctgtgc tgactcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggc aataattttg tttcctggta ccagcagcgg      120

ccaggaacag cccccagcct cctcatttat gaaactaaca agcgaccctc aggaattcct      180

gaccgattct ctggctccaa gtctgccacg tcagccaccc tggccatcac cgggctccag      240

actggggacg aggccgatta ttactgcgcc acgtgggctg ccagcctgac ttccgcgcgt      300

gtcttcggaa ctgggaccaa ggtaatcgtc tca                                   333


<210>  89
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  89
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctcactt ctcccttagt agttatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgacaggt atctcatttg ctggaactaa gacatactat      180

ggagattccg tgaggggccg tttcaccgtc tccagagaca tttccaagaa cacgttgttc      240

ctgcaaatga acagcctgcg acctgacgac acggctatgt attactgtgc gagagatcag      300

cgatattacg agtgtgaaga gtgggcgtcg gattattacg attttgggag agagcaacct      360

tgcctagacc cacggggcgt ggttggaatt ttcgatttgt ggggccaagg gacaatggtc      420

accgtctctt cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccc      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      720

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      780

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1080

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aatga                     1425


<210>  90
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  90
cagtctgccc tgactcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaaacattgg gaataattat gtttcttggt accagcaagt cccaggaaca      120

gcccccaaac tcctcatcta tgaaaataac aagcgaccct caggcattcc tgaccgattc      180

tctggctcta agtctggcac gtcagccacc ctggtcatca ccggactcca gactggggac      240

gaggccgatt tttactgcgg aacatggggt ggcagcctga gaactggcgg tgtcctcgga      300

actgggacca gggtcaccgt cctaggtcag cccaaggcca accccactgt cactctgttc      360

ccgccctcga gtgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctacctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt catag                      645


<210>  91
<211>  432
<212>  DNA
<213>  Homo sapiens

<400>  91
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctcactt ctcccttagt agttatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgacaggt atctcatttg ctggaactaa gacatactat      180

ggagattccg tgaggggccg tttcaccgtc tccagagaca tttccaagaa cacgttgttc      240

ctgcaaatga acagcctgcg acctgacgac acggctatgt attactgtgc gagagatcag      300

cgatattacg agtgtgaaga gtgggcgtcg gattattacg attttgggag agagcaacct      360

tgcctagacc cacggggcgt ggttggaatt ttcgatttgt ggggccaagg gacaatggtc      420

accgtctctt ca                                                          432


<210>  92
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  92
cagtctgccc tgactcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaaacattgg gaataattat gtttcttggt accagcaagt cccaggaaca      120

gcccccaaac tcctcatcta tgaaaataac aagcgaccct caggcattcc tgaccgattc      180

tctggctcta agtctggcac gtcagccacc ctggtcatca ccggactcca gactggggac      240

gaggccgatt tttactgcgg aacatggggt ggcagcctga gaactggcgg tgtcctcgga      300

actgggacca gggtcaccgt ccta                                             324


<210>  93
<211>  1428
<212>  DNA
<213>  Homo sapiens

<400>  93
gaggtgcagc tgattgagtc ggggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtggag cgtctggatt cagcttcaat aactatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaggt atttcctttg ctggaatcaa gaaatactat      180

ggaacttccg tgaagggccg attcaccatc tcccgagaca attccaagaa caatttctat      240

ctgcaaatga acagcctgcg agttgaggac acggctctct attattgtgc gagagatctg      300

cgagaattgg aatgtgaaga gtggacacta tataattatt atgactttgg aagtcgaggc      360

ccttgtgtag acccacgggg cgtggctgga tcttttgatg tctggggcca ggggacaatg      420

gtgaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      480

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      540

cccgtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      600

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      660

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      720

aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      780

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      840

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      900

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      960

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1020

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1080

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1140

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1200

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1260

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1320

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1380

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                  1428


<210>  94
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  94
cagtctgtgc tgactcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcacttc caaaattggg caaaactctg tatcttggta ccagcaactc      120

ccaggaacag cccccaaact cctcatctat gaaaatgacc ggcgaccctc ggggactcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

actggggacg aggccgaata ttactgcgaa acatgggatg gcagcggggg tgtcttcgga      300

actgggacca aggtcaccgt cctaggtcag cccaaggcca accccactgt cactctgttc      360

ccgccctcga gtgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctacctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt catag                      645


<210>  95
<211>  435
<212>  DNA
<213>  Homo sapiens

<400>  95
gaggtgcagc tgattgagtc ggggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtggag cgtctggatt cagcttcaat aactatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaggt atttcctttg ctggaatcaa gaaatactat      180

ggaacttccg tgaagggccg attcaccatc tcccgagaca attccaagaa caatttctat      240

ctgcaaatga acagcctgcg agttgaggac acggctctct attattgtgc gagagatctg      300

cgagaattgg aatgtgaaga gtggacacta tataattatt atgactttgg aagtcgaggc      360

ccttgtgtag acccacgggg cgtggctgga tcttttgatg tctggggcca ggggacaatg      420

gtgaccgtct cctca                                                       435


<210>  96
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  96
cagtctgtgc tgactcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcacttc caaaattggg caaaactctg tatcttggta ccagcaactc      120

ccaggaacag cccccaaact cctcatctat gaaaatgacc ggcgaccctc ggggactcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

actggggacg aggccgaata ttactgcgaa acatgggatg gcagcggggg tgtcttcgga      300

actgggacca aggtcaccgt ccta                                             324


<210>  97
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  97
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgtag gctctcaatt cagttttaat cgatatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcgggt atatcatttg atggaactga cagatatcat      180

gcagacaatg tgtggggccg cttcaccatc tccagagaca attccaagaa cacactgtat      240

ctacaaatga gcagcctgcg cgctgaggac acggctctct attattgtgc gaaagatttg      300

cgagaagacg aatgtgaaga gtggtggtcg gattattacg attttgggaa aaaactccct      360

tgccgaaagt cacggggcgt ggctggagtt tttgataagt ggggccaagg gacaatggtc      420

accgtctctt cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccc      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      720

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      780

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1080

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aatga                     1425


<210>  98
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  98
caggctgtgc tgactcagcc gccctcagtg tctgcggccc caggacagaa cgtcaccatc       60

tcctgctctg gaagcggctc caacattggc aataattttg tatcctggta ccagcaacgc      120

ccaggaacag cccccaaact cctcatttat gagtctaaca agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cgggctccag      240

actggggacg aggcctatta ttactgcgcc acatgggctg ccaggctgaa ttccgcgcgt      300

gtcttcggaa ctgggaccat ggtcaccgtc ctaggtcagc ccaaggccaa ccccactgtc      360

actctgttcc cgccctcgag tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctacctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            654


<210>  99
<211>  432
<212>  DNA
<213>  Homo sapiens

<400>  99
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgtag gctctcaatt cagttttaat cgatatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcgggt atatcatttg atggaactga cagatatcat      180

gcagacaatg tgtggggccg cttcaccatc tccagagaca attccaagaa cacactgtat      240

ctacaaatga gcagcctgcg cgctgaggac acggctctct attattgtgc gaaagatttg      300

cgagaagacg aatgtgaaga gtggtggtcg gattattacg attttgggaa aaaactccct      360

tgccgaaagt cacggggcgt ggctggagtt tttgataagt ggggccaagg gacaatggtc      420

accgtctctt ca                                                          432


<210>  100
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  100
caggctgtgc tgactcagcc gccctcagtg tctgcggccc caggacagaa cgtcaccatc       60

tcctgctctg gaagcggctc caacattggc aataattttg tatcctggta ccagcaacgc      120

ccaggaacag cccccaaact cctcatttat gagtctaaca agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cgggctccag      240

actggggacg aggcctatta ttactgcgcc acatgggctg ccaggctgaa ttccgcgcgt      300

gtcttcggaa ctgggaccat ggtcaccgtc cta                                   333


<210>  101
<211>  1431
<212>  DNA
<213>  Homo sapiens

<400>  101
gaagtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgacactg       60

tcctgtgcag cctctcaatt cactttttcg aattatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcaagt gtatcaaatg atggaaccaa gaaatatcat      180

ggagattccg tgtggggccg attcaccatc tccagagaca attccaagaa cacactgttt      240

ctacaaatga gcagcctgcg agctgaggac acggctgtat atttctgtgt gagagatcaa      300

cgagaagacg agtgtgaaga gtggtggtcg gattattatg attttgggag agagctccct      360

tgccgaaaat tccggggcct gggcctggct ggaatttttg atatctgggg ccacgggaca      420

atggtcaccg tctcttcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      480

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaacccgtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      720

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      780

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      840

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      900

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      960

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1020

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1080

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1140

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1200

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1260

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1320

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1380

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatg a              1431


<210>  102
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  102
cagtctgccc tgactcagcc gccctcagtg tccgcggccc caggacagaa ggtcaccatc       60

tcctgctccg gaaacagctc caacattggg aataattttg tatcctggta ccagcaagtc      120

ccaggaacag cccccaaact cctcctgtat gaaacttaca ggcgaccctc aggtattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

actggggacg aggccgacta ctactgcaca gtatggggtg tcaggaaggg tgtcggcgct      300

gtcttcggaa ctgggaccaa ggtcaccgtc ctaggtcagc ccaaggccaa ccccactgtc      360

actctgttcc cgccctcgag tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctacctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            654


<210>  103
<211>  438
<212>  DNA
<213>  Homo sapiens

<400>  103
gaagtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgacactg       60

tcctgtgcag cctctcaatt cactttttcg aattatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcaagt gtatcaaatg atggaaccaa gaaatatcat      180

ggagattccg tgtggggccg attcaccatc tccagagaca attccaagaa cacactgttt      240

ctacaaatga gcagcctgcg agctgaggac acggctgtat atttctgtgt gagagatcaa      300

cgagaagacg agtgtgaaga gtggtggtcg gattattatg attttgggag agagctccct      360

tgccgaaaat tccggggcct gggcctggct ggaatttttg atatctgggg ccacgggaca      420

atggtcaccg tctcttca                                                    438


<210>  104
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  104
cagtctgccc tgactcagcc gccctcagtg tccgcggccc caggacagaa ggtcaccatc       60

tcctgctccg gaaacagctc caacattggg aataattttg tatcctggta ccagcaagtc      120

ccaggaacag cccccaaact cctcctgtat gaaacttaca ggcgaccctc aggtattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

actggggacg aggccgacta ctactgcaca gtatggggtg tcaggaaggg tgtcggcgct      300

gtcttcggaa ctgggaccaa ggtcaccgtc cta                                   333


<210>  105
<211>  1431
<212>  DNA
<213>  Homo sapiens

<400>  105
gaggtgcagt tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgacactg       60

tcctgtgcag cctctcaatt caattttgcg aattatggca tgcactgggt ccgccaggct      120

ccaggcaagg gattggagtg ggtggcaagt atatcaaatg atggaacgaa gaaatatcat      180

gaagaatccg tgtggggccg attcaccatc tccaaagaca attccaagag cacactattt      240

ctacaaatga acagcctgcg aattgaggac acggccctat atttctgtgt gaaagatcaa      300

cgagaggacg aatgtgaaga gtggtggtcg gattattatg attttgggag agagctccct      360

tgccgaaagt cccggggcct gggcctggct ggaatctttg atatgtgggg ccacgggaca      420

atggtcaccg tctcttcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      480

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaacccgtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      720

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      780

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      840

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      900

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      960

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1020

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1080

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1140

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1200

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1260

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1320

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1380

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatg a              1431


<210>  106
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  106
cagtctgccc tgactcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaaatagttc caacattggg aataattttg tatcctggta ccagcaactc      120

ccggggacag cccccaaact cctcatatat gaaaataaca ggcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcag cggactccag      240

actggggacg aggccgacta ttggtgcgct gtttggggtg tcaggcgggg tgccggcgct      300

gtcttcggag ctgggaccaa ggtcaccgtc ctaggtcagc ccaaggccaa ccccactgtc      360

actctgttcc cgccctcgag tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctacctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            654


<210>  107
<211>  438
<212>  DNA
<213>  Homo sapiens

<400>  107
gaggtgcagt tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgacactg       60

tcctgtgcag cctctcaatt caattttgcg aattatggca tgcactgggt ccgccaggct      120

ccaggcaagg gattggagtg ggtggcaagt atatcaaatg atggaacgaa gaaatatcat      180

gaagaatccg tgtggggccg attcaccatc tccaaagaca attccaagag cacactattt      240

ctacaaatga acagcctgcg aattgaggac acggccctat atttctgtgt gaaagatcaa      300

cgagaggacg aatgtgaaga gtggtggtcg gattattatg attttgggag agagctccct      360

tgccgaaagt cccggggcct gggcctggct ggaatctttg atatgtgggg ccacgggaca      420

atggtcaccg tctcttca                                                    438


<210>  108
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  108
cagtctgccc tgactcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaaatagttc caacattggg aataattttg tatcctggta ccagcaactc      120

ccggggacag cccccaaact cctcatatat gaaaataaca ggcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcag cggactccag      240

actggggacg aggccgacta ttggtgcgct gtttggggtg tcaggcgggg tgccggcgct      300

gtcttcggag ctgggaccaa ggtcaccgtc cta                                   333


<210>  109
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  109
caggcgatcc tggtggaatc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctcgcaatt cacatttagt ggacatggcc tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcctct atttcttttg ctggaactaa aatggactat      180

gcagattccg tgaagggccg attcgccatc tccagagaca actccaagaa cacgttgtat      240

ctgcaaatga acagcctgcg agttgaggac acggctctat attactgtgc aaaagatatg      300

cgagaatatg aatgtgaata ttggacgtcg gattattacg attttgggag acctcaaccg      360

tgcatagacc gacggggcgt ggttggaatt tttgatatgt ggggccaagg gacaatggtc      420

accgtctcta cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccc      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      720

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      780

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1080

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aatga                     1425


<210>  110
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  110
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg gataattatg tgtcctggta ccagcacctc      120

ccaggaacag cccccaaact cctcatctat gaaaatacca ggcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggatg tcagaccgaa tcgtggcgct      300

gtcttcggaa ctgggacgaa ggtcaccgtc ctaggtcagc ccaaggccaa ccccactgtc      360

actctgttcc cgccctcgag tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctacctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            654


<210>  111
<211>  432
<212>  DNA
<213>  Homo sapiens

<400>  111
caggcgatcc tggtggaatc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctcgcaatt cacatttagt ggacatggcc tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcctct atttcttttg ctggaactaa aatggactat      180

gcagattccg tgaagggccg attcgccatc tccagagaca actccaagaa cacgttgtat      240

ctgcaaatga acagcctgcg agttgaggac acggctctat attactgtgc aaaagatatg      300

cgagaatatg aatgtgaata ttggacgtcg gattattacg attttgggag acctcaaccg      360

tgcatagacc gacggggcgt ggttggaatt tttgatatgt ggggccaagg gacaatggtc      420

accgtctcta ca                                                          432


<210>  112
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  112
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg gataattatg tgtcctggta ccagcacctc      120

ccaggaacag cccccaaact cctcatctat gaaaatacca ggcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggatg tcagaccgaa tcgtggcgct      300

gtcttcggaa ctgggacgaa ggtcaccgtc cta                                   333


<210>  113
<211>  1422
<212>  DNA
<213>  Homo sapiens

<400>  113
gaggtgcagc tggtggagtc tgggggaggc gtggtcccgc ctgggaagtc cctgacactc       60

tcctgtgtag cctctcgatt cacctttagt gcctttggga tgcactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggcaagt atatcatttg ctggaattaa gaaatattat      180

gcagattccg tgaagggccg attcagcatc tccagagaca attccaacac actgtttctc      240

caaatgaatg gcctgcgagg agaagacacg ggtctatatc actgtgtcaa agatatgcga      300

gagttggagt gtgaagagtg ggcgtcggat tactacgatt ttgggaagcc tcagccttgt      360

ctggaccgac ggggcgtgtc tggaatctct gcttggtggg gtcctgggac aatggtcacc      420

gtctcttcag cgtcgaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      480

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaacccgtg      540

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      600

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      660

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      720

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      780

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      840

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      900

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      960

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1020

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1080

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1140

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1200

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1260

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1320

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1380

cactacacgc agaagagcct ctccctgtct ccgggtaaat ga                        1422


<210>  114
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  114
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa cgtcaccatc       60

tcctgctctg gacccccgtc ccacattgag aagaatgatg tgtcgtggta ccaacgcctc      120

ccaggaatgg cccccaaaat ggtcatttat gaaagtaaaa ggcgacctct cgggatccct      180

gtccgattct ctgcctccag gtctggctcg tcagccaccc tggtcatcac cggactccag      240

actgccgacg aggccgatta ttactgcgga acatgggatg gcagaatgaa ttttgggact      300

gggaccacgg tctccgtcct aggtcagccc aaggccaacc ccactgtcac tctgttcccg      360

ccctcgagtg aggagcttca agccaacaag gccacactgg tgtgtctcat aagtgacttc      420

tacccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg      480

gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctacctgagc      540

ctgacgcctg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg      600

agcaccgtgg agaagacagt ggcccctaca gaatgttcat ag                         642


<210>  115
<211>  429
<212>  DNA
<213>  Homo sapiens

<400>  115
gaggtgcagc tggtggagtc tgggggaggc gtggtcccgc ctgggaagtc cctgacactc       60

tcctgtgtag cctctcgatt cacctttagt gcctttggga tgcactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggcaagt atatcatttg ctggaattaa gaaatattat      180

gcagattccg tgaagggccg attcagcatc tccagagaca attccaacac actgtttctc      240

caaatgaatg gcctgcgagg agaagacacg ggtctatatc actgtgtcaa agatatgcga      300

gagttggagt gtgaagagtg ggcgtcggat tactacgatt ttgggaagcc tcagccttgt      360

ctggaccgac ggggcgtgtc tggaatctct gcttggtggg gtcctgggac aatggtcacc      420

gtctcttca                                                              429


<210>  116
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  116
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa cgtcaccatc       60

tcctgctctg gacccccgtc ccacattgag aagaatgatg tgtcgtggta ccaacgcctc      120

ccaggaatgg cccccaaaat ggtcatttat gaaagtaaaa ggcgacctct cgggatccct      180

gtccgattct ctgcctccag gtctggctcg tcagccaccc tggtcatcac cggactccag      240

actgccgacg aggccgatta ttactgcgga acatgggatg gcagaatgaa ttttgggact      300

gggaccacgg tctccgtcct a                                                321


<210>  117
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  117
gaagtgcagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag ccccgtattt cgagtttggt agatatggct tccactgggt ccgccaggct      120

ccaggcaagg gtctggagtg ggtggcaagt atatcatttg ctggaagaga ttattaccac      180

tcaccatccg tgtggggccg cttcaccatc tccagagaca attccaagaa cacactatat      240

ttgcaaatga acagcctgcg aattgaagac acggctctct atttctgtgc gagagatctg      300

agagaaagcg aatgtgaaga gtgggagtcg gactattatg attttgggaa aaagggccct      360

tgtgttaagc cgcggggcgt ggctggaggt ttggatctct ggggccaagg gacaatggtc      420

atcgtctcat cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccc      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      720

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      780

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      900

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      960

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1020

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1080

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aatga                     1425


<210>  118
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  118
cagtctgtgc tgacgcagcc gccctcagtg tctacggccc caggacagac ggtcaccgtc       60

tcctgctccg gaggcacctc caacactggg aataattttg tctcctggta ccaacacctc      120

ccaggaacag cccccaaact tctcatctat gaaaataaca agcgaccctt aggggttcct      180

gaccgattct ctggcgccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

actggggacg agggcgatta ttactgcgca acatggagtg gcagtctgaa catcgggact      300

gggaccaaag tctccgtcct aggtcagccc aaggccaacc ccactgtcac tctgttcccg      360

ccctcgagtg aggagcttca agccaacaag gccacactgg tgtgtctcat aagtgacttc      420

tacccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg      480

gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctacctgagc      540

ctgacgcctg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg      600

agcaccgtgg agaagacagt ggcccctaca gaatgttcat ag                         642


<210>  119
<211>  432
<212>  DNA
<213>  Homo sapiens

<400>  119
gaagtgcagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag ccccgtattt cgagtttggt agatatggct tccactgggt ccgccaggct      120

ccaggcaagg gtctggagtg ggtggcaagt atatcatttg ctggaagaga ttattaccac      180

tcaccatccg tgtggggccg cttcaccatc tccagagaca attccaagaa cacactatat      240

ttgcaaatga acagcctgcg aattgaagac acggctctct atttctgtgc gagagatctg      300

agagaaagcg aatgtgaaga gtgggagtcg gactattatg attttgggaa aaagggccct      360

tgtgttaagc cgcggggcgt ggctggaggt ttggatctct ggggccaagg gacaatggtc      420

atcgtctcat ca                                                          432


<210>  120
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  120
cagtctgtgc tgacgcagcc gccctcagtg tctacggccc caggacagac ggtcaccgtc       60

tcctgctccg gaggcacctc caacactggg aataattttg tctcctggta ccaacacctc      120

ccaggaacag cccccaaact tctcatctat gaaaataaca agcgaccctt aggggttcct      180

gaccgattct ctggcgccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

actggggacg agggcgatta ttactgcgca acatggagtg gcagtctgaa catcgggact      300

gggaccaaag tctccgtcct a                                                321


<210>  121
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic VH consensus sequence


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (23)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (53)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(63)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (69)..(70)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (76)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (88)..(89)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (92)..(93)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (97)..(98)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (100)..(107)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (109)..(112)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (116)..(120)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (122)..(125)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (127)..(131)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (133)..(136)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (139)..(139)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (144)..(144)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (147)..(147)
<223>  Xaa can be any naturally occurring amino acid

<400>  121

Xaa Xaa Xaa Xaa Xaa Xaa Ser Gly Gly Gly Val Val Xaa Pro Gly Xaa 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Xaa Xaa Xaa Ser Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val 
    50                  55                  60                  


Xaa Gly Arg Phe Xaa Xaa Ser Xaa Asp Xaa Ser Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Leu Gln Met Xaa Xaa Leu Arg Xaa Xaa Asp Thr Xaa Xaa Tyr Xaa Cys 
                85                  90                  95      


Xaa Xaa Asp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Xaa Xaa Xaa Xaa 
            100                 105                 110         


Tyr Tyr Asp Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa Xaa Xaa Arg Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Trp Gly Xaa Gly Thr Met Val Xaa 
    130                 135                 140                 


Val Ser Xaa 
145         


<210>  122
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic VL consensus sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (25)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (38)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(49)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (51)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(61)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (65)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (69)..(70)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (85)..(88)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (90)..(91)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (93)..(102)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (107)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa can be any naturally occurring amino acid

<400>  122

Gln Xaa Xaa Leu Thr Gln Pro Pro Ser Val Ser Xaa Ala Pro Gly Gln 
1               5                   10                  15      


Xaa Val Thr Xaa Ser Cys Ser Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Val Ser Trp Tyr Xaa Xaa Xaa Pro Xaa Xaa Ala Pro Xaa Xaa Xaa 
        35                  40                  45              


Xaa Tyr Xaa Xaa Xaa Xaa Arg Pro Xaa Xaa Xaa Xaa Xaa Arg Phe Ser 
    50                  55                  60                  


Xaa Xaa Xaa Ser Xaa Xaa Ser Ala Thr Leu Xaa Ile Xaa Gly Leu Gln 
65                  70                  75                  80  


Thr Xaa Asp Glu Xaa Xaa Xaa Xaa Cys Xaa Xaa Trp Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Gly Thr Xaa Xaa Xaa Val Xaa 
            100                 105                 110     


<210>  123
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_VH3 LEADER-A

<400>  123
ccatctcatc cctgcgtgtc tccgactcag taaaaggtgt ccagtgt                     47


<210>  124
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_VH3 LEADER-B

<400>  124
ccatctcatc cctgcgtgtc tccgactcag taagaggtgt ccagtgt                     47


<210>  125
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_VH3 LEADER-C

<400>  125
ccatctcatc cctgcgtgtc tccgactcag tagaaggtgt ccagtgt                     47


<210>  126
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_VH3 LEADER-D

<400>  126
ccatctcatc cctgcgtgtc tccgactcag gctattttta aaggtgtcca gtgt             54


<210>  127
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_VH3 LEADER-E

<400>  127
ccatctcatc cctgcgtgtc tccgactcag tacaaggtgt ccagtgt                     47


<210>  128
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_VH3 LEADER-F

<400>  128
ccatctcatc cctgcgtgtc tccgactcag ttaaagctgt ccagtgt                     47


<210>  129
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-B_3xwCgammaCH1-2

<400>  129
cctatcccct gtgtgccttg gcagtctcag ggggaagacc gatgggccct tggt             54


<210>  130
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-B_3CmuCH1

<400>  130
cctatcccct gtgtgccttg gcagtctcag gggaattctc acaggagacg a                51


<210>  131
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VL1/2

<400>  131
ccatctcatc cctgcgtgtc tccgactcag gcacagggtc ctgggcccag tctg             54


<210>  132
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VL3

<400>  132
ccatctcatc cctgcgtgtc tccgactcag gctctgtgac ctcctatgag ctg              53


<210>  133
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VL4/5

<400>  133
ccatctcatc cctgcgtgtc tccgactcag ggtctctctc scagcytgtg ctg              53


<210>  134
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VL6

<400>  134
ccatctcatc cctgcgtgtc tccgactcag gttcttgggc caattttatg ctg              53


<210>  135
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VL7/8

<400>  135
ccatctcatc cctgcgtgtc tccgactcag gagtggattc tcagactgtg gtg              53


<210>  136
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5MP-VL1

<400>  136
ccatctcatc cctgcgtgtc tccgactcag gctcactgca cagggtcctg ggcc             54


<210>  137
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5MP-VL3-1

<400>  137
ccatctcatc cctgcgtgtc tccgactcag gcttactgca caggatccgt ggcc             54


<210>  138
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5MP-VL3-19

<400>  138
ccatctcatc cctgcgtgtc tccgactcag actctttgca taggttctgt ggtt             54


<210>  139
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5MP-VL3-21

<400>  139
ccatctcatc cctgcgtgtc tccgactcag tctcactgca caggctctgt gacc             54


<210>  140
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5MP-VL7-43

<400>  140
ccatctcatc cctgcgtgtc tccgactcag acttgctgcc cagggtccaa ttc              53


<210>  141
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-B_3CL

<400>  141
cctatcccct gtgtgccttg gcagtctcag caccagtgtg gccttgttgg cttg             54


<210>  142
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VH1

<400>  142
ccatctcatc cctgcgtgtc tccgactcag acaggtgccc actcccaggt gcag             54


<210>  143
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VH3

<400>  143
ccatctcatc cctgcgtgtc tccgactcag aaggtgtcca gtgtgargtg cag              53


<210>  144
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VH4/6

<400>  144
ccatctcatc cctgcgtgtc tccgactcag cccagatggg tcctgtccca ggtgcag          57


<210>  145
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VH5

<400>  145
ccatctcatc cctgcgtgtc tccgactcag caaggagtct gttccgaggt gcag             54


<210>  146
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5xwL-VH1

<400>  146
ccatctcatc cctgcgtgtc tccgactcag gcagccacag gtgcccactc c                51


<210>  147
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5xwL-VH1-24

<400>  147
ccatctcatc cctgcgtgtc tccgactcag cagcagctac aggcacccac gc               52


<210>  148
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5xwL-VH1-69

<400>  148
ccatctcatc cctgcgtgtc tccgactcag ggcagcagct acaggtgtcc agtcc            55


<210>  149
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_VH3-L1-MP

<400>  149
ccatctcatc cctgcgtgtc tccgactcag gctattttaa aaggtgtcca atgt             54


<210>  150
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_VH3/4-L1-MP

<400>  150
ccatctcatc cctgcgtgtc tccgactcag gtggcagctc ccagatgggt cctgtc           56


<210>  151
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_VH3/4-L3-MP

<400>  151
ccatctcatc cctgcgtgtc tccgactcag gttgcagttt taaaaggtgt ccagtg           56


<210>  152
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_VH5-L1-MP

<400>  152
ccatctcatc cctgcgtgtc tccgactcag gctgttctcc aaggagtctg ttcc             54


<210>  153
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5xwL-VK1/2

<400>  153
ccatctcatc cctgcgtgtc tccgactcag atgaggstcc cygctcagct cctggg           56


<210>  154
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VK3

<400>  154
ccatctcatc cctgcgtgtc tccgactcag ctcttcctcc tgctactctg gctcccag         58


<210>  155
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VK4

<400>  155
ccatctcatc cctgcgtgtc tccgactcag atttctctgt tgctctggat ctctg            55


<210>  156
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VL1/2

<400>  156
ccatctcatc cctgcgtgtc tccgactcag gcacagggtc ctgggcccag tctg             54


<210>  157
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VL3

<400>  157
ccatctcatc cctgcgtgtc tccgactcag gctctgtgac ctcctatgag ctg              53


<210>  158
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VL4/5

<400>  158
ccatctcatc cctgcgtgtc tccgactcag ggtctctctc scagcytgtg ctg              53


<210>  159
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VL6

<400>  159
ccatctcatc cctgcgtgtc tccgactcag gttcttgggc caattttatg ctg              53


<210>  160
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5L-VL7/8

<400>  160
ccatctcatc cctgcgtgtc tccgactcag gagtggattc tcagactgtg gtg              53


<210>  161
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5MP-VL1

<400>  161
ccatctcatc cctgcgtgtc tccgactcag gctcactgca cagggtcctg ggcc             54


<210>  162
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5MP-VL3-1

<400>  162
ccatctcatc cctgcgtgtc tccgactcag gcttactgca caggatccgt ggcc             54


<210>  163
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5MP-VL3-19

<400>  163
ccatctcatc cctgcgtgtc tccgactcag actctttgca taggttctgt ggtt             54


<210>  164
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5MP-VL3-21

<400>  164
ccatctcatc cctgcgtgtc tccgactcag tctcactgca caggctctgt gacc             54


<210>  165
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-A_5MP-VL7-43

<400>  165
ccatctcatc cctgcgtgtc tccgactcag acttgctgcc cagggtccaa ttc              53


<210>  166
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-B_3xwCK1

<400>  166
cctatcccct gtgtgccttg gcagtctcag cagcaggcac acaacagagg cagttcc          57


<210>  167
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer XLR-B_3CL

<400>  167
cctatcccct gtgtgccttg gcagtctcag caccagtgtg gccttgttgg cttg             54


<210>  168
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer EnvM

<400>  168
tagcccttcc agtcccccct tttctttta                                         29


<210>  169
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide primer EnvAstop

<400>  169
caccggctta ggcatctcct atggcaggaa gaa                                    33


<210>  170
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Thr Ser Leu Arg Leu Ser Cys Ala Ala Ser Gln Phe Arg Phe 
        35                  40                  45              


Asp Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ser Ile Ser His Asp Gly Ile Lys Lys Tyr His Ala 
65                  70                  75                  80  


Glu Lys Val Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Asp Leu Arg Glu Asp Glu Cys Glu Glu Trp Trp 
        115                 120                 125             


Ser Asp Tyr Tyr Asp Phe Gly Lys Gln Leu Pro Cys Ala Lys Ser Arg 
    130                 135                 140                 


Gly Gly Leu Val Gly Ile Ala Asp Asn Trp Gly Gln Gly Thr Met Val 
145                 150                 155                 160 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                165                 170                 175     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            180                 185                 190         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        195                 200                 205             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    210                 215                 220                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
225                 230                 235                 240 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                245                 250                 255     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
305                 310                 315                 320 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 


<210>  171
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala 
            20                  25                  30          


Pro Gly Gln Lys Val Thr Ile Ser Cys Ser Gly Asn Thr Ser Asn Ile 
        35                  40                  45              


Gly Asn Asn Phe Val Ser Trp Tyr Gln Gln Arg Pro Gly Arg Ala Pro 
    50                  55                  60                  


Gln Leu Leu Ile Tyr Glu Thr Asp Lys Arg Pro Ser Gly Ile Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Ala Ser Lys Ser Gly Thr Ser Gly Thr Leu Ala Ile Thr 
                85                  90                  95      


Gly Leu Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Ala 
            100                 105                 110         


Ala Ser Leu Ser Ser Ala Arg Val Phe Gly Thr Gly Thr Gln Val Ile 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Val Asn Pro Thr Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210>  172
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  172

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gln Phe Arg Phe Asp Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser His Asp Gly Ile Lys Lys Tyr His Ala Glu Lys Val 
    50                  55                  60                  


Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Lys Gln Leu Pro Cys Ala Lys Ser Arg Gly Gly Leu 
        115                 120                 125             


Val Gly Ile Ala Asp Asn Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140                 


Ser 
145 


<210>  173
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  173

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Asn Thr Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Val Ser Trp Tyr Gln Gln Arg Pro Gly Arg Ala Pro Gln Leu Leu 
        35                  40                  45              


Ile Tyr Glu Thr Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Ala Ser Lys Ser Gly Thr Ser Gly Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Ala Ala Ser Leu 
                85                  90                  95      


Ser Ser Ala Arg Val Phe Gly Thr Gly Thr Gln Val Ile Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Val Asn Pro Thr Val Thr Leu 
        115                 120         


<210>  174
<211>  1485
<212>  DNA
<213>  Homo sapiens

<400>  174
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattctcag       60

gtgcagctgg tggagtctgg gggaggcgtg gtccagcctg ggacgtccct gagactctcc      120

tgtgcagcct ctcaattcag gtttgatggt tatggcatgc actgggtccg ccaggcccca      180

ggcaaggggc tggagtgggt ggcatctata tcacatgatg gaattaaaaa gtatcacgca      240

gaaaaagtgt ggggccgctt caccatctcc agagacaatt ccaagaacac actgtatcta      300

caaatgaaca gcctgcgacc tgaggacacg gctctctact actgtgcgaa agatttgcga      360

gaagacgaat gtgaagagtg gtggtcggat tattacgatt ttgggaaaca actcccttgc      420

gcaaagtcac gcggcggctt ggttggaatt gctgataact ggggccaagg gacaatggtc      480

accgtctctt cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccaag      540

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccc      600

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      660

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      720

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      780

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      840

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      900

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      960

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     1020

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1080

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1140

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1200

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1260

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1320

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1380

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1440

aaccactaca cgcagaagag cctctccctg tctccgggta aatga                     1485


<210>  175
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  175
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggttc ctgggcccag       60

tctgtgctga ctcagccgcc ctcagtgtct gcggccccag gacagaaggt caccatctcc      120

tgctctggaa acacctccaa cattggtaat aattttgtgt cctggtacca acagcgcccc      180

ggcagagccc cccaactcct catttatgaa actgacaagc gaccctcagg gattcctgac      240

cgattctctg cttccaagtc tggtacgtca ggcaccctgg ccatcaccgg gctgcagact      300

ggggacgagg ccgactatta ctgcgccaca tgggctgcca gcctgagttc cgcgcgtgtc      360

ttcggaactg ggacccaggt catcgtccta ggtcagccca aggtcaaccc cactgtcact      420

ctgttcccgc cctcgagtga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      480

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      540

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      600

tacctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      660

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttcata g               711


<210>  176
<211>  435
<212>  DNA
<213>  Homo sapiens

<400>  176
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggacgtc cctgagactc       60

tcctgtgcag cctctcaatt caggtttgat ggttatggca tgcactgggt ccgccaggcc      120

ccaggcaagg ggctggagtg ggtggcatct atatcacatg atggaattaa aaagtatcac      180

gcagaaaaag tgtggggccg cttcaccatc tccagagaca attccaagaa cacactgtat      240

ctacaaatga acagcctgcg acctgaggac acggctctct actactgtgc gaaagatttg      300

cgagaagacg aatgtgaaga gtggtggtcg gattattacg attttgggaa acaactccct      360

tgcgcaaagt cacgcggcgg cttggttgga attgctgata actggggcca agggacaatg      420

gtcaccgtct cttca                                                       435


<210>  177
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  177
cagtctgtgc tgactcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaaacacctc caacattggt aataattttg tgtcctggta ccaacagcgc      120

cccggcagag ccccccaact cctcatttat gaaactgaca agcgaccctc agggattcct      180

gaccgattct ctgcttccaa gtctggtacg tcaggcaccc tggccatcac cgggctgcag      240

actggggacg aggccgacta ttactgcgcc acatgggctg ccagcctgag ttccgcgcgt      300

gtcttcggaa ctgggaccca ggtcatcgtc ctaggtcagc ccaaggtcaa ccccactgtc      360

actctg                                                                 366


<210>  178
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  178

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gln Phe Ala Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Arg Asp Glu Thr Lys Lys Tyr His Gly Asp Ser Val 
    50                  55                  60                  


Trp Asp Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Val Arg Asp Gln Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Lys Glu Leu Pro Cys Arg Lys Phe Arg Gly Leu Gly 
        115                 120                 125             


Leu Ala Gly Ile Phe Asp Val Trp Gly His Gly Thr Met Val Ile Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  179
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  179

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Ser Ile Ser Cys Ser Gly Asn Asn Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Ile Ser Trp Phe Gln Gln Phe Pro Gly Thr Ala Pro Lys Pro Leu 
        35                  40                  45              


Ile Tyr Glu Thr Tyr Lys Arg His Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Gly Val Arg Gln 
                85                  90                  95      


Gly Val Gly Ala Leu Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  180
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gln Phe Ala Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Arg Asp Glu Thr Lys Lys Tyr His Gly Asp Ser Val 
    50                  55                  60                  


Trp Asp Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Val Arg Asp Gln Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Lys Glu Leu Pro Cys Arg Lys Phe Arg Gly Leu Gly 
        115                 120                 125             


Leu Ala Gly Ile Phe Asp Val Trp Gly His Gly Thr Met Val Ile Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  181
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  181

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Ser Ile Ser Cys Ser Gly Asn Asn Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Ile Ser Trp Phe Gln Gln Phe Pro Gly Thr Ala Pro Lys Pro Leu 
        35                  40                  45              


Ile Tyr Glu Thr Tyr Lys Arg His Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Gly Val Arg Gln 
                85                  90                  95      


Gly Val Gly Ala Leu Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  182
<211>  1431
<212>  DNA
<213>  Homo sapiens

<400>  182
gaggtgcagc tggtggagtc tgggggaggc atagtccagc ctgggaggtc cctgacactg       60

tcttgtgtag cctctcaatt cgctttttcg cattatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggccagt atctcaaggg atgagaccaa gaaatatcat      180

ggagattccg tgtgggaccg attcagtatc tccagagaca attccaagaa taccctgttt      240

ctacaaatga acagcctgcg agctgaggac acggcactat atttctgtgt gagagatcag      300

cgagaagacg aatgtgagga gtggtggtcg gactattatg attttgggaa agaactccct      360

tgccgaaaat tccggggcct gggcctggct ggaatttttg atgtctgggg ccacgggaca      420

atggtcatcg tctcttcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      480

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaacccgtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      720

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      780

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      840

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      900

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      960

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1020

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1080

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1140

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1200

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1260

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1320

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1380

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatg a              1431


<210>  183
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  183
cagtctgccc tgactcagcc gccctcagtg tctgcggccc caggacagaa ggtctccatc       60

tcctgctctg gaaacaactc aaacattggg aataacttta tatcctggtt ccagcaattc      120

ccaggaacag cccccaaacc cctcatatat gaaacttaca agcgacactc aggtattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

actggggacg aggccgacta ttactgcgca acatggggtg tcaggcaggg tgtcggcgct      300

ctcttcggaa ctgggactaa ggtcaccgtc ctaggtcagc ccaaggccaa ccccactgtc      360

actctgttcc cgccctcgag tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctacctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            654


<210>  184
<211>  438
<212>  DNA
<213>  Homo sapiens

<400>  184
gaggtgcagc tggtggagtc tgggggaggc atagtccagc ctgggaggtc cctgacactg       60

tcttgtgtag cctctcaatt cgctttttcg cattatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggccagt atctcaaggg atgagaccaa gaaatatcat      180

ggagattccg tgtgggaccg attcagtatc tccagagaca attccaagaa taccctgttt      240

ctacaaatga acagcctgcg agctgaggac acggcactat atttctgtgt gagagatcag      300

cgagaagacg aatgtgagga gtggtggtcg gactattatg attttgggaa agaactccct      360

tgccgaaaat tccggggcct gggcctggct ggaatttttg atgtctgggg ccacgggaca      420

atggtcatcg tctcttca                                                    438


<210>  185
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  185
cagtctgccc tgactcagcc gccctcagtg tctgcggccc caggacagaa ggtctccatc       60

tcctgctctg gaaacaactc aaacattggg aataacttta tatcctggtt ccagcaattc      120

ccaggaacag cccccaaacc cctcatatat gaaacttaca agcgacactc aggtattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

actggggacg aggccgacta ttactgcgca acatggggtg tcaggcaggg tgtcggcgct      300

ctcttcggaa ctgggactaa ggtcaccgtc cta                                   333


<210>  186
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  186

Gln Lys Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gln Phe Pro Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Asn Asp Gly Thr Lys Lys Tyr His Gly Glu Ser Val 
    50                  55                  60                  


Trp Asp Arg Phe Arg Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Val Arg Asp Gln Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Lys Glu Leu Pro Cys Arg Lys Phe Arg Gly Leu Gly 
        115                 120                 125             


Leu Ala Gly Ile Phe Asp Ile Trp Gly His Gly Thr Met Val Ile Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  187
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  187

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Ser Ile Ser Cys Ser Gly Asn Asn Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Ile Ser Trp Phe Gln Gln Phe Pro Gly Thr Ala Pro Lys Pro Leu 
        35                  40                  45              


Ile Tyr Glu Thr Tyr Arg Arg His Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Gly Val Arg Gln 
                85                  90                  95      


Gly Val Gly Ala Leu Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  188
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  188

Gln Lys Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gln Phe Pro Phe Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Asn Asp Gly Thr Lys Lys Tyr His Gly Glu Ser Val 
    50                  55                  60                  


Trp Asp Arg Phe Arg Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Val Arg Asp Gln Arg Glu Asp Glu Cys Glu Glu Trp Trp Ser Asp Tyr 
            100                 105                 110         


Tyr Asp Phe Gly Lys Glu Leu Pro Cys Arg Lys Phe Arg Gly Leu Gly 
        115                 120                 125             


Leu Ala Gly Ile Phe Asp Ile Trp Gly His Gly Thr Met Val Ile Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  189
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  189

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Ser Ile Ser Cys Ser Gly Asn Asn Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Phe Ile Ser Trp Phe Gln Gln Phe Pro Gly Thr Ala Pro Lys Pro Leu 
        35                  40                  45              


Ile Tyr Glu Thr Tyr Arg Arg His Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Gly Val Arg Gln 
                85                  90                  95      


Gly Val Gly Ala Leu Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  190
<211>  1431
<212>  DNA
<213>  Homo sapiens

<400>  190
cagaagcagt tggtggagtc tgggggaggc gtagtccagc ctgggaggtc cctgacactg       60

tcctgtgcag cctctcaatt ccctttttcg cattatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaagt attacaaatg atgggaccaa gaaatatcat      180

ggagagtccg tgtgggaccg attcaggatc tccagagaca attccaagaa tacactcttt      240

ctacaaatga acagcctgcg agctgaggac acggcactat atttctgtgt gagagatcag      300

cgagaagacg aatgtgaaga gtggtggtcg gattattatg attttgggaa agaactccct      360

tgccgaaaat tccggggcct gggcctggct ggaatttttg atatctgggg ccacgggaca      420

atggtcatcg tctcatcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      480

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaacccgtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      720

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      780

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      840

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      900

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      960

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1020

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1080

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1140

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1200

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1260

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1320

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1380

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatg a              1431


<210>  191
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  191
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtctccatc       60

tcctgctctg gaaacaattc aaacattggg aataacttta tatcctggtt ccagcaattc      120

ccaggaacag cccccaaacc cctcatatat gaaacttaca ggcgacactc aggtattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

actggggacg aggccgacta ttactgcgca acatggggtg tcaggcaggg tgtcggcgct      300

ctcttcggaa ctgggactaa ggtcaccgtc ctaggtcagc ccaaggccaa ccccactgtc      360

actctgttcc cgccctcgag tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctacctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            654


<210>  192
<211>  438
<212>  DNA
<213>  Homo sapiens

<400>  192
cagaagcagt tggtggagtc tgggggaggc gtagtccagc ctgggaggtc cctgacactg       60

tcctgtgcag cctctcaatt ccctttttcg cattatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaagt attacaaatg atgggaccaa gaaatatcat      180

ggagagtccg tgtgggaccg attcaggatc tccagagaca attccaagaa tacactcttt      240

ctacaaatga acagcctgcg agctgaggac acggcactat atttctgtgt gagagatcag      300

cgagaagacg aatgtgaaga gtggtggtcg gattattatg attttgggaa agaactccct      360

tgccgaaaat tccggggcct gggcctggct ggaatttttg atatctgggg ccacgggaca      420

atggtcatcg tctcatca                                                    438


<210>  193
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  193
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtctccatc       60

tcctgctctg gaaacaattc aaacattggg aataacttta tatcctggtt ccagcaattc      120

ccaggaacag cccccaaacc cctcatatat gaaacttaca ggcgacactc aggtattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tggccatcac cggactccag      240

actggggacg aggccgacta ttactgcgca acatggggtg tcaggcaggg tgtcggcgct      300

ctcttcggaa ctgggactaa ggtcaccgtc cta                                   333


