                         SEQUENCE LISTING

<110>  APEPTICO Forschung und Entwicklung GmbH
 
<120>  Attenuation of intrapulmonary inflammation

<130>  A 18761

<150>  A 50158/2014
<151>  2014-03-04

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cyclized compound for use in inflammation


<220>
<221>  DISULFID
<222>  (1)..(17)

<400>  1

Cys Gly Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
1               5                   10                  15      


Cys 
    


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cyclized compound for use in inflammation


<220>
<221>  TURN
<222>  (1)..(19)
<223>  amide bond formed between the amino group attached to the 
       epsilon-carbon atom of the N-terminal lysine residue and the side
       chain carboxyl group attached to the gamma-carbon atom of the 
       C-terminal glutamic acid residue

<400>  2

Lys Ser Pro Gly Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro 
1               5                   10                  15      


Trp Tyr Glu 
            


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cyclized compound for use in inflammation


<220>
<221>  TURN
<222>  (1)..(17)
<223>  amide bond formed between the amino group attached to the 
       epsilon-carbon atom of the side chain of the N-terminal lysine 
       residue and the carboxyl group of the C-terminal glycine residue

<400>  3

Lys Gly Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cyclized compound for use in inflammation


<220>
<221>  TURN
<222>  (1)..(17)
<223>  amide bond formed between the amino group attached to the 
       delta-carbon of the side chain of the N-terminal ornithine 
       residue and the carboxyl group of the C-terminal glycine residue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X = ornithine

<400>  4

Xaa Gly Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cyclized compound for use in inflammation


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X = 4-aminobutanoic acid

<220>
<221>  TURN
<222>  (1)..(17)
<223>  amide bond formed between the amino group of the N-terminal 
       4-aminobutanoic acid residue and the side chain carboxyl group 
       attached to the beta-carbon of the C-terminal aspartic acid 
       residue

<400>  5

Xaa Gly Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
1               5                   10                  15      


Asp 
    


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cyclized compound for use in inflammation


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X = beta-alanine

<220>
<221>  TURN
<222>  (1)..(17)
<223>  amide bond formed between the amino group of the N-terminal 
       -alanine (3-aminopropanoic acid) residue and the side chain 
       carboxyl group attached to the gamma-carbon of the C-terminal 
       glutamic acid residue

<400>  6

Xaa Gly Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
1               5                   10                  15      


Glu 
    


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cyclized compound for use in inflammation


<220>
<221>  TURN
<222>  (1)..(16)
<223>  amide bond between N of amino group of the N-terminal glycine and
       carbon C1 of carboxyl group of 7-amino-heptanoic acid, and amide 
       bond between N of amino group of 7-amino-heptanoic acid and C of 
       carboxyl group of the C-terminal tyrosine

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X = 7-amino-heptanoic acid

<400>  7

Xaa Gly Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
1               5                   10                  15      


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cyclized compound for use in inflammation


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X = 6-amino-hexanoic acid

<220>
<221>  TURN
<222>  (1)..(17)
<223>  amide bond between N of amino group of the N-terminal glycine and
       C1 of carboxyl group of the 6-amino-hexanoic acid, and amide bond
       between N of amino group of the 6-amino-hexanoic acid and C of 
       the carboxyl group of the C-terminal glycine

<400>  8

Xaa Gly Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cyclized compound for use in inflammation


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X = amino acid/amino acid sequence with 1 to 4, in particular 1 
       to 3 members, comprising natural or unnatural amino acids, in 
       particular selected from the amino acid/ amino acid sequence C, 
       KSP, K, ornithin, 4-amino butanoic acid, beta-alanine

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  X = one amino acid selected from natural amino acids, in 
       particular selected from the group C, D, G and E

<400>  9

Xaa Gly Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
1               5                   10                  15      


Xaa 
    


