                         SEQUENCE LISTING

<110>  Stichting Katholieke Universiteit
 
<120>  A genetically attenuated, live organism of the Plasmodium genus

<130>  P6050280PCT

<150>  EP14158007.6
<151>  2014-03-06

<160>  20    

<170>  PatentIn version 3.3

<210>  1
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  1
ggggcgcgcg aatcaaaagg aggttcttc                                       29


<210>  2
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  2
gggcgtacgt tcatgtaata cgcatacc                                        28


<210>  3
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  3
gggcccgggc ttacacacac ccatgcatac                                      30


<210>  4
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  4
ggggctagcg taactatttc tgaccaattc                                      30


<210>  5
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  5
ggggcgcgcc ttcttacatt tgtttatcg                                       29


<210>  6
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  6
gggcgtacgc gaaattgtaa acgcttctcc g                                    31


<210>  7
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  7
gggcccgggc cgaattagct aacttgc                                         27


<210>  8
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  8
ggggctagcg gttcatgcaa atgtttatgc                                      30


<210>  9
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  9
caaatgcatg aatattgg                                                   18


<210>  10
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  10
tcaaaataat caactagcc                                                  19


<210>  11
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  11
gacgacatat aaagaaaatg ttgg                                            24


<210>  12
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  12
cttgcatcat ttgaattaca atgg                                            24


<210>  13
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  13
catgacaaga ataataacga c                                               21


<210>  14
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  14
ctcaataagg aggattcatc                                                 20


<210>  15
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  15
cagaatgatc agaatgagca aagcg                                           25


<210>  16
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer with homology to Plasmodium falciparum

<400>  16
gcctgtacac gttaaacatg tcg                                             23


<210>  17
<211>  1822
<212>  PRT
<213>  Plasmodium falciparum

<400>  17

Met Thr Thr Tyr Lys Glu Asn Val Gly Ile Ser Asn Lys Gly Asn Lys 
1               5                   10                  15      


Lys Lys Lys Ser Cys Gln Asn Ile Ser Phe Leu Asn Phe Leu Ser Phe 
            20                  25                  30          


Asp Trp Ile Arg Pro Leu Ile Asn Asp Leu Ile Lys Gly Asp Ile Gln 
        35                  40                  45              


Glu Leu Pro Asn Ile Cys Arg Asn Phe Asp Val Pro Tyr Tyr Ala Ser 
    50                  55                  60                  


Lys Leu Glu Glu Asn Leu Arg Asp Ile Glu Val Glu Asp Ser Glu Phe 
65                  70                  75                  80  


Tyr Ser Glu Lys Asn Ser Ser Asn Glu His Val Leu His His Cys Asn 
                85                  90                  95      


Ser Asn Asp Ala Ser Glu Lys Lys Val Tyr Asn Val Tyr Tyr His Asn 
            100                 105                 110         


Ile Leu Trp Ser Ile Leu Lys Thr Phe Lys Phe Arg Ile Ile Leu Ile 
        115                 120                 125             


Ile Ser Phe Tyr Ile Leu Glu Thr Leu Ile Val Thr Leu Gly Gly Lys 
    130                 135                 140                 


Phe Ile Asp Tyr Tyr Met Arg Ile Leu Glu Gly Gln Lys Ile Pro Val 
145                 150                 155                 160 


Tyr Ile Ser Phe Leu Lys Asp Phe Lys Val Phe Ser Gly Leu Val Val 
                165                 170                 175     


Val Met Ile Met Phe Phe His Leu Phe Phe Glu Ala Leu Leu His Phe 
            180                 185                 190         


Tyr Phe His Leu Phe Thr Ile Asn Leu Lys Val Ser Leu Met Tyr Phe 
        195                 200                 205             


Leu Tyr Lys Ile Asn Leu Cys Ser Asn Asn Asn His Leu Gln Asn Pro 
    210                 215                 220                 


Asp Ala Phe Tyr Asn Thr Tyr Arg Lys Phe Ser Ser Gln Thr Glu Ile 
225                 230                 235                 240 


Asp Glu Ile Ser Arg Asp Phe Leu Ser Ile Gly Lys Asn Ala Ser Ser 
                245                 250                 255     


Ser Ser Ser Gly Ile Lys Asn Asn Asn Lys Asn Ile Asp Asn Asn Lys 
            260                 265                 270         


Phe Val Glu Asn Asp Tyr Ile Ile Asn Phe Ile Lys Ser Thr Lys Lys 
        275                 280                 285             


Met Glu Lys Asp Ser Leu Asn Glu Asn Arg Ser Leu Pro Asn Val Asn 
    290                 295                 300                 


Ile Tyr Asn Ile Met Phe Ser Asp Val Pro Ser Val Thr Phe Phe Val 
305                 310                 315                 320 


Thr Ser Cys Ile Asn Leu Phe Asn Val Phe Val Lys Ile Phe Met Ser 
                325                 330                 335     


Phe Tyr Val Phe His Ile Lys Ile Gly Ser Asn Ser Val Gly Ile Ala 
            340                 345                 350         


Ile Trp Leu Ser Ile Ala Leu Tyr Ser Ala Met Ile Leu Phe Glu Phe 
        355                 360                 365             


Leu Pro Ser Leu Phe Lys Ser Lys Tyr Leu Ile Tyr Arg Asp Lys Arg 
    370                 375                 380                 


Ile Asp Asn Met His His Val Leu Lys Glu Phe Lys Leu Ile Lys Met 
385                 390                 395                 400 


Phe Asn Trp Glu Ser Phe Ala Phe Lys Tyr Ile Asn Ile Phe Arg Met 
                405                 410                 415     


Lys Glu Met Lys Tyr Cys Lys Ile Arg Leu Tyr Leu Ser Asn Ile Gly 
            420                 425                 430         


Val Phe Ile Ser Ser Ile Ser Ser Asp Ile Val Glu Val Val Ile Phe 
        435                 440                 445             


Phe Ile Tyr Leu Lys Asp Arg Leu Asn Lys Lys Glu Glu Ile Lys Phe 
    450                 455                 460                 


Thr Ser Ile Ile Met Pro Leu Tyr Val Tyr Lys Ile Leu Ile Ser Asn 
465                 470                 475                 480 


Val Ala Asn Phe Pro Asn Leu Val Asn Asn Val Met Glu Gly Ile Val 
                485                 490                 495     


Asn Ile Lys Arg Leu Asn Asn Tyr Ile Asn Asp His Leu Tyr Tyr Asn 
            500                 505                 510         


Asp Ile Lys Asn Tyr Phe Met Tyr Arg Thr Arg Tyr Asn Glu Asp Tyr 
        515                 520                 525             


Asn Ile Val Val Asp Lys Thr Phe Leu Gln Asn Glu Asn Ile Thr Ser 
    530                 535                 540                 


His Asp Asp Gly Thr Ser His Asn Leu Lys His Leu Lys Asn Val Ile 
545                 550                 555                 560 


Lys Asn Lys Leu Thr Asn Met Phe Lys Tyr Phe Phe Phe Tyr His Lys 
                565                 570                 575     


Met Asn Tyr His Lys Asn Ile Ile Asn Lys Gln Ile Leu Ser Gly Leu 
            580                 585                 590         


Leu Lys Asn Val Asp Asp Asn Thr Asn Lys Lys Ile Cys Phe Gln Glu 
        595                 600                 605             


His Lys Ser Asn Ser Thr Tyr Asn Tyr Asn Ser Ser His Ile His Glu 
    610                 615                 620                 


Lys Lys Glu Glu Tyr Glu Asn Ile His Asn Ser Ser Asn Ser Thr Met 
625                 630                 635                 640 


Ser Asn Glu Phe Lys Glu Lys Lys Lys Asn Asn Glu Tyr Ile Ile Lys 
                645                 650                 655     


Leu Glu Asn Cys Ser Phe Gly Leu Ser Tyr Asp Asn Lys Cys Asp Asn 
            660                 665                 670         


Asp His Ile Leu Lys Asn Ile Asn Phe Asn Leu Lys Arg Asn Ser Leu 
        675                 680                 685             


Ala Ile Ile Ile Gly Asn Val Gly Ser Gly Lys Ser Ala Phe Phe His 
    690                 695                 700                 


Ser Ile Leu Gly Asp Phe Asn Met Thr His Gly Asn Leu Tyr Ile Glu 
705                 710                 715                 720 


Asn Phe Phe Lys Lys Met Pro Ile Leu Tyr Val Pro Gln Asn Ser Trp 
                725                 730                 735     


Leu Phe Met Gly Asn Ile Arg Ser Met Ile Leu Phe Gly Asn Glu Tyr 
            740                 745                 750         


Asn Pro Leu Ile Tyr Lys Tyr Thr Ile Leu Gln Ser Glu Leu Leu Asn 
        755                 760                 765             


Asp Leu Ser Thr Ile Glu His Gly Asp Met Lys Tyr Ile Asn Asp Asp 
    770                 775                 780                 


His Asn Leu Ser Lys Gly Gln Lys Val Arg Ile Cys Leu Ala Arg Ala 
785                 790                 795                 800 


Leu Tyr Glu His Tyr Ile His Met His Lys Leu Cys Thr Asp Tyr Glu 
                805                 810                 815     


Lys Lys Leu Ile Gln Pro Asn Glu Ile Leu Asp Lys Asp Leu Ile Asn 
            820                 825                 830         


Asn Lys Asn Ile Ser Ser Tyr Asn Asn Lys Lys Ser Lys Leu Val Asn 
        835                 840                 845             


Tyr Asn Ile Pro Phe Asn Glu Asn Tyr Leu Gln Lys Cys Leu Met Asp 
    850                 855                 860                 


Asp Asn Asn Phe Tyr Leu Tyr Leu Leu Asp Asp Ile Phe Thr Ser Leu 
865                 870                 875                 880 


Asp Pro Ser Ile Ser Lys Lys Ile Phe Ser Asn Leu Phe Cys Lys Glu 
                885                 890                 895     


Asp Asn Ile Ser Phe Lys Asp Asn Cys Ser Phe Ile Ile Ser Met Asn 
            900                 905                 910         


Lys Ser Thr Leu Asp Asn Phe Leu Ile Glu Asp Ile Leu Asp Asn Val 
        915                 920                 925             


Gln Tyr Glu Val Asn Ile Phe Glu Ile Gln Asp Lys Thr Leu Lys Tyr 
    930                 935                 940                 


Arg Gly Asn Ile Ser Glu Tyr Met Glu Lys Asn Asn Leu Asn Ile Thr 
945                 950                 955                 960 


Lys Glu Ser His Trp Gly Tyr Ser Asn Leu Asn Thr Ile Asp Tyr Thr 
                965                 970                 975     


Arg Ile Lys Leu Phe Asp Glu Val Glu Leu Asn His Val Lys His Ser 
            980                 985                 990         


Asn Lys Met Ile Tyr Lys Glu Ala  Tyr Phe Val Lys Gly  Asn Thr Glu 
        995                 1000                 1005             


Ser Val  Ser Phe Glu Ile Asp  Ser Ile Asn Lys Glu  Tyr Ile Lys 
    1010                 1015                 1020             


Lys Met  Lys Lys Lys Asn Tyr  Lys Lys Glu His Met  Asn Lys Asn 
    1025                 1030                 1035             


Asn Lys  Asp Asn Asn Asn Asn  Asn Asn Asn Ser Asn  Lys Asp Asp 
    1040                 1045                 1050             


His Ile  Asn Ile Asn Met Asn  Asp Asn His Arg Asn  Tyr Asn Asp 
    1055                 1060                 1065             


Ile Asn  Leu Gly Pro Asn Ser  Thr Asp Asp Ser Pro  Thr Val Ser 
    1070                 1075                 1080             


Ser Leu  Gly Asn Glu Tyr Thr  Leu Asp Thr Tyr Thr  Ser Asn Asn 
    1085                 1090                 1095             


Ser Asp  Lys Glu Glu Ile Val  Lys Pro Leu Tyr Lys  Asp Thr His 
    1100                 1105                 1110             


Glu Glu  Phe Asn Lys Ser Ser  Ser Met Pro Phe Val  Lys Ser Ser 
    1115                 1120                 1125             


Ser Asn  Met Ile Asn Asn Pro  Ser Asn Phe Lys Tyr  Glu Asp Asn 
    1130                 1135                 1140             


Ser Ser  Ser Phe Lys Gly Ser  Ile Ser Leu Glu Thr  Tyr Leu Trp 
    1145                 1150                 1155             


Tyr Phe  Gln Gln Val Gly Phe  Val Leu Leu Thr Ser  Val Val Ile 
    1160                 1165                 1170             


Phe Met  Leu Ile Ser Ile Phe  Thr Asp Glu Ile Lys  Phe Val Phe 
    1175                 1180                 1185             


Leu Thr  Met Met Ser Ile Ile  Ser Lys Asn Asn Lys  Glu His Ser 
    1190                 1195                 1200             


Asp Thr  Ile Leu Gln Lys Gln  Val Arg Tyr Leu Glu  Tyr Phe Val 
    1205                 1210                 1215             


Ile Leu  Pro Ile Ile Ser Leu  Val Thr Ser Gly Ile  Cys Phe Ser 
    1220                 1225                 1230             


Met Ile  Ile Tyr Gly Asn Ile  Thr Ser Ala Ile Lys  Val His Asn 
    1235                 1240                 1245             


Asn Ile  Leu Tyr Ser Ile Leu  Asn Ala Pro Leu Tyr  Ile Phe Tyr 
    1250                 1255                 1260             


Asn Asn  Asn Leu Gly Asn Ile  Ile Asn Arg Phe Ile  Ile Asp Ile 
    1265                 1270                 1275             


Ser Ala  Phe Asp Tyr Gly Phe  Leu Lys Arg Ile Tyr  Lys Ala Phe 
    1280                 1285                 1290             


Phe Ile  Phe Phe Arg Cys Ile  Leu Ser Ser Leu Leu  Ile Ile Tyr 
    1295                 1300                 1305             


Met Ile  Arg Asp Cys Ile Phe  Ile Phe Pro Phe Val  Ile Ile Leu 
    1310                 1315                 1320             


Ile Tyr  Phe Phe Val Phe Lys  Arg Phe Ser Arg Gly  Cys Lys Glu 
    1325                 1330                 1335             


Ala Gln  Arg Leu Tyr Leu Ser  Cys His Thr Pro Leu  Cys Asn Ile 
    1340                 1345                 1350             


Tyr Ser  Asn Ala Leu Ser Gly  Lys Asn Ile Ile Asn  Ile Tyr Lys 
    1355                 1360                 1365             


Lys Asn  Thr Tyr His Leu Asp  Val Tyr Glu His Tyr  Ile Asn Asn 
    1370                 1375                 1380             


Phe Arg  Ile Ser Tyr Phe Phe  Lys Trp Leu Ile Asn  Ile Trp Ala 
    1385                 1390                 1395             


Ser Leu  Tyr Ile Lys Ile Phe  Ile Leu Leu Leu Thr  Thr Tyr Ile 
    1400                 1405                 1410             


Ile Met  His Pro His Leu Tyr  Ala Ser Gly Ile Ile  Lys Leu Tyr 
    1415                 1420                 1425             


Lys Glu  Lys Asn Tyr Val Arg  Ile Leu Ser Thr Leu  Gly Tyr Cys 
    1430                 1435                 1440             


Ile Ser  Phe Ser Ala Arg Leu  Gly Val Ile Ile Lys  Phe Leu Leu 
    1445                 1450                 1455             


Cys Asp  Tyr Thr His Ile Glu  Lys Glu Met Cys Cys  Val Gln Arg 
    1460                 1465                 1470             


Leu Glu  Glu Phe Ala Lys Ile  Ser Asn Lys Glu Asn  Ala Ser Met 
    1475                 1480                 1485             


Asn Lys  Glu Asn Glu Leu Asn  Val Ile Thr Thr Gln  Thr Tyr Lys 
    1490                 1495                 1500             


Glu Lys  Asn Glu Asn Ile Ser  Asp Lys Ile Ser Ala  Ile Val Glu 
    1505                 1510                 1515             


Tyr Lys  Asn Val Ser Leu Ser  Ser Ile Ile Asn Ser  Ser Gln Asp 
    1520                 1525                 1530             


Asp Glu  Ser Lys Lys Lys Tyr  Gly Ile Lys Phe Glu  Asn Val Tyr 
    1535                 1540                 1545             


Val Ser  Tyr Lys Lys Lys Ile  Pro Leu Val Asn Gly  Thr Tyr Lys 
    1550                 1555                 1560             


Tyr Ile  Asp Glu Glu Pro Ser  Leu Lys Asn Ile Asn  Met Tyr Ala 
    1565                 1570                 1575             


Leu Lys  Asn Gln Lys Ile Gly  Ile Val Gly Lys Ser  Gly Ala Gly 
    1580                 1585                 1590             


Lys Ser  Thr Ile Leu Leu Ser  Ile Leu Gly Leu Ile  Asn Ile Ser 
    1595                 1600                 1605             


Gln Gly  Lys Ile Thr Val Glu  Gly Arg Asp Ile Arg  Thr Tyr Asn 
    1610                 1615                 1620             


Arg Lys  Gly Glu Asp Ser Ile  Ile Gly Ile Leu Ala  Gln Ser Ser 
    1625                 1630                 1635             


Phe Val  Phe Tyr Asn Trp Asn  Ile Arg Thr Phe Ile  Asp Pro Tyr 
    1640                 1645                 1650             


Asn Asn  Phe Thr Asp Asp Glu  Ile Val His Ala Leu  Lys Leu Asn 
    1655                 1660                 1665             


Gly Ile  Asn Leu Gly Lys Asn  Asp Leu Tyr Lys Tyr  Met His Lys 
    1670                 1675                 1680             


Gln Asp  Met Lys Ser Asn Tyr  Lys Lys Ile Ile Gln  Thr Ser Lys 
    1685                 1690                 1695             


Val Ile  Asn Gln Ser Asn Asp  Asn Thr Ile Leu Leu  Thr Asn Asp 
    1700                 1705                 1710             


Cys Ile  Arg Tyr Leu Ser Leu  Val Arg Leu Tyr Leu  Asn Arg His 
    1715                 1720                 1725             


Lys Tyr  Lys Ile Ile Leu Ile  Asp Glu Ile Pro Ile  Phe Asn Leu 
    1730                 1735                 1740             


Asn Asn  Ser Val His Asp Glu  Leu Asn Ser Phe Leu  Ile Gly Lys 
    1745                 1750                 1755             


Ala Lys  Ser Phe Asn Tyr Ile  Ile Arg Asn His Phe  Pro Asn Asn 
    1760                 1765                 1770             


Thr Val  Leu Ile Ile Ser His  His Ala Asn Thr Leu  Ser Cys Cys 
    1775                 1780                 1785             


Asp Tyr  Ile Tyr Val Leu Arg  Lys Gly Glu Ile Thr  Tyr Arg Cys 
    1790                 1795                 1800             


Ser Tyr  Glu Asp Val Lys Thr  Gln Ser Glu Leu Ser  His Leu Leu 
    1805                 1810                 1815             


Glu Met  Asp Asp 
    1820         


<210>  18
<211>  5469
<212>  DNA
<213>  Plasmodium falciparum

<400>  18
atgacgacat ataaagaaaa tgttggaata tcaaataaag gaaataaaaa aaaaaaaagt     60

tgtcaaaata tatcattttt aaatttttta tcttttgatt ggataagacc gttaataaat    120

gatttaataa aaggagatat tcaagaactt cctaatatat gtcggaactt cgatgtgcca    180

tattatgcat ctaaattaga agagaattta agagatatag aagtagaaga ctccgaattt    240

tacagtgaaa aaaattcatc taacgaacat gtattacacc attgtaattc aaatgatgca    300

agtgaaaaga aagtgtataa tgtttattac cataatattt tatggtcaat tttgaaaaca    360

tttaagtttc gaataatttt aataataagt ttttatattt tagagacatt aattgttacc    420

ttggggggga aattcataga ttactatatg cgtattttag aaggtcaaaa gattcctgta    480

tatatttcat tcttaaaaga tttcaaagta ttcagtgggt tagtggtagt gatgataatg    540

tttttccatt tgttttttga agctcttttg catttttatt ttcatctctt tacaataaat    600

ttaaaagtat cactaatgta ttttttgtat aaaattaatt tatgcagtaa taacaatcat    660

ttacaaaatc cagatgcatt ttataataca tatagaaaat tttcttcaca aacagaaatt    720

gatgagataa gcagagattt tttaagtatt ggtaagaatg catcctcctc ttcatcagga    780

ataaaaaata ataataaaaa tatcgataat aataaatttg tggaaaatga ttatataatt    840

aattttataa aaagtacaaa gaaaatggaa aaagattcat taaatgaaaa taggagttta    900

cctaatgtga acatttataa tattatgttt tctgatgtac cgtctgtaac attttttgtt    960

acttcttgta ttaatttgtt taatgtattt gttaaaattt ttatgtcttt ttatgtgttt   1020

catataaaga ttgggtccaa ttcagttgga attgcaatat ggttgtccat tgctttatac   1080

agtgcaatga tactatttga atttttacca agtttattta aaagtaaata tttaatttat   1140

cgagataaaa gaattgataa catgcatcat gtattaaaag aattcaaatt gataaaaatg   1200

tttaattggg aatcatttgc ttttaaatac ataaatatat ttcgaatgaa agaaatgaaa   1260

tattgtaaaa taagacttta tttgagtaac ataggagttt ttataagttc aatttcctct   1320

gatatagttg aagtggttat attctttatt tatttaaaag atagattaaa taagaaagaa   1380

gaaattaaat ttacatcaat tattatgccc ttatatgtat ataagatatt aatttcgaat   1440

gtagcaaatt ttccaaactt agttaataat gttatggaag gtatagtaaa tattaaacgt   1500

ttaaataatt atattaatga tcatttatat tataatgata taaaaaatta ttttatgtac   1560

cgtacaagat ataatgaaga ttataatatt gtagtggata agacattttt acaaaatgaa   1620

aatataactt ctcatgatga tggtacatca cataatttga aacatttaaa aaacgtaata   1680

aaaaataaat taacaaatat gtttaaatat tttttctttt atcataagat gaattatcat   1740

aagaatataa taaataaaca aatattatct ggtttactta agaacgtaga tgataatacg   1800

aataaaaaaa tatgtttcca ggaacataaa agtaattcta catataatta taatagtagt   1860

catatacatg aaaaaaaaga agaatatgaa aatattcaca atagtagtaa tagcacaatg   1920

agtaatgaat tcaaagaaaa aaaaaagaat aatgaataca ttataaaatt agaaaattgt   1980

agttttggtt tatcatatga taataaatgt gataatgacc atattttaaa aaacataaat   2040

tttaatttaa aaaggaattc attagcaata attataggaa atgttggatc aggaaaaagt   2100

gcatttttcc attctatatt aggagatttt aatatgacac atggtaattt gtatattgaa   2160

aattttttca aaaaaatgcc aatcttatat gttcctcaaa atagttggtt atttatggga   2220

aatattagat caatgatttt atttggaaat gaatataatc cattaattta taaatatact   2280

atattacaaa gtgaattatt gaatgatttg agtaccatag aacatggaga tatgaaatat   2340

attaatgatg atcataattt aagtaaagga caaaaagtaa gaatatgttt agctagagca   2400

ttatatgagc attatattca tatgcacaaa ttatgtacag attatgaaaa aaagcttata   2460

caacctaatg aaatattaga taaggattta ataaataata aaaacatttc ttcatataat   2520

aataaaaaaa gtaaattagt taactataat attccattca atgaaaatta ccttcaaaaa   2580

tgtttaatgg atgataataa tttttatttg tatttacttg atgatatatt tacatcttta   2640

gatccttcca tatctaaaaa gatattttct aatttatttt gtaaagaaga caatataagt   2700

tttaaagata attgtagttt tattatctca atgaataaaa gtacgttgga taattttctt   2760

attgaagata ttcttgataa tgttcaatat gaagtaaaca tttttgaaat tcaggataaa   2820

actttaaaat atagaggaaa tatatcagaa tatatggaaa agaacaattt aaatataact   2880

aaagaaagtc actggggtta ttcaaactta aatacaatag attataccag aataaaattg   2940

tttgatgaag tggaacttaa tcatgttaaa catagtaata aaatgatata taaggaagct   3000

tatttcgtaa aagggaatac ggagagtgtt tcctttgaaa ttgatagtat aaataaggag   3060

tatattaaga aaatgaaaaa gaaaaattat aaaaaggagc atatgaataa aaataataag   3120

gacaacaata ataataataa taatagtaac aaggacgacc atattaatat taatatgaat   3180

gataaccata gaaactataa tgacattaat ttggggccta attctacaga tgatagtcca   3240

actgtttctt cgttaggaaa tgaatatacg cttgatacct atactagtaa taattctgat   3300

aaggaagaaa ttgtaaaacc tttatataaa gatacacatg aagaattcaa taaaagttca   3360

tcaatgcctt ttgtcaaaag ttcaagtaat atgataaata atccaagtaa ttttaaatat   3420

gaagataact catccagttt taagggttcc ataagtttag aaacgtattt atggtatttt   3480

caacaggttg gatttgtttt attaacttca gtagtaatat ttatgcttat atctattttt   3540

acagatgaaa taaagtttgt ctttttaact atgatgagta ttatttctaa aaataataaa   3600

gaacattcag acacaatatt acaaaagcaa gtaagatatt tggaatattt tgtaatatta   3660

ccaataatat cattagtaac atcaggtata tgtttttcta tgatcatata tggaaatatt   3720

acatcagcaa taaaagtaca taataatata ttatatagca tattaaatgc accattgtat   3780

atattttata ataataattt agggaatata ataaatcgat ttattattga tatatctgct   3840

tttgattatg gatttttaaa gagaatatat aaagcctttt tcattttttt tcgttgtatc   3900

ttatcatcct tattaattat atatatgata agagattgta tttttatttt cccttttgta   3960

attatattaa tatatttttt tgttttcaaa agattttcga gaggttgtaa agaagcacaa   4020

aggctgtatt tatcatgtca tactccttta tgtaacatct atagtaatgc attgtctgga   4080

aaaaacatta ttaatatata taaaaaaaat acatatcatt tggatgtata tgagcattat   4140

ataaacaatt ttcgaattag ttattttttt aaatggctta taaatatttg ggcatctctt   4200

tatattaaga tttttatatt gttattaact acttacatta ttatgcatcc tcatttatat   4260

gcaagtggaa taatcaaatt atataaagaa aaaaattatg ttcgaatttt gagtaccctt   4320

ggatactgta tatcgttttc tgctagacta ggtgttatta taaaatttct tttatgtgat   4380

tatactcaca tagaaaaaga aatgtgctgt gttcaaagat tagaagaatt tgctaaaatt   4440

tctaataaag aaaatgcttc tatgaataag gaaaatgaat taaatgtaat aacaacacaa   4500

acatataagg aaaaaaatga aaatatctcg gataagatat ctgcaattgt cgaatataaa   4560

aatgtatcgt tatcttcaat tataaatagt tctcaggatg atgaatcaaa aaaaaagtat   4620

ggtattaaat ttgagaatgt atatgtaagt tataaaaaaa aaattccttt agttaatggt   4680

acatataaat acatagatga agaaccatca ttaaaaaata ttaatatgta tgctttaaaa   4740

aatcaaaaaa ttgggatagt aggaaaatca ggcgcaggaa aaagtactat acttttatct   4800

atcttaggat taattaatat ttcacaagga aaaataacag tagaaggaag agacattcga   4860

acatataata gaaaaggaga agatagtatt attggtattt tagctcaatc ttcttttgtt   4920

ttttataatt ggaatataag aacttttatt gatccatata ataatttcac agatgatgaa   4980

attgttcatg ctctaaaatt gaatggtata aatttaggta aaaacgattt atataaatat   5040

atgcataaac aagatatgaa atcaaattat aaaaaaataa tacaaacatc aaaagtaata   5100

aaccaatcaa atgataatac tattctatta acaaatgatt gtataagata tctatcttta   5160

gttagacttt atttaaatcg acataaatat aaaatcatat taatagatga aattcctatt   5220

tttaatttaa acaattctgt tcatgacgaa ttaaatagtt ttttaattgg taaagcaaag   5280

tcatttaatt atataataag aaatcatttt ccaaataata cagtcctaat tatttcacat   5340

catgcaaata ctttgtcttg ttgtgactat atttatgtat taagaaaggg agaaataact   5400

tatcgttgta gttacgaaga tgtaaaaacg caatctgaat tatcacattt gttagaaatg   5460

gacgactaa                                                           5469


<210>  19
<211>  2108
<212>  PRT
<213>  Plasmodium falciparum

<400>  19

Met Met Arg Arg Arg Ser Val Tyr Asn Phe Asp Gln Gly Lys His Gly 
1               5                   10                  15      


Tyr Leu Met Asn His Ile Ser Trp Leu Asn Phe Val Ser Phe Asn Trp 
            20                  25                  30          


Ile Thr Gln Leu Leu Arg Cys Leu Lys Asn Asp Asp Phe Val Leu Pro 
        35                  40                  45              


Cys Ile Glu Glu Thr Ser Ser Ile Glu His Tyr Ser Thr Asn Leu Asn 
    50                  55                  60                  


Arg Asn Val Arg Asn Ile Gln Leu Arg Lys Tyr Asn Lys Tyr Asn Lys 
65                  70                  75                  80  


Tyr Lys Asn Tyr Cys Cys Ser Lys Tyr Asn Asp Gly Asn Lys Ser Cys 
                85                  90                  95      


Ser Cys Ser Thr Lys Asn His Thr Asn Lys Phe His Lys Arg Lys Lys 
            100                 105                 110         


Glu Asp His Phe Leu Lys Ser Ser Gly Ile Thr Tyr Ala Val Leu Lys 
        115                 120                 125             


Thr Phe Lys Tyr Tyr Leu Ser Leu Ile Ser Phe Phe His Ile Ile His 
    130                 135                 140                 


Thr Ile Phe Leu Ile Phe Val Ala Val Cys Ile Glu Lys Tyr Val Leu 
145                 150                 155                 160 


Leu Ile Lys Gly Gly Ser Asn Val Val Thr Leu Pro Phe Gly Phe Lys 
                165                 170                 175     


Asn Ser Lys Val Leu Phe Gly Phe Ile Val Ile Ser Val Ile Phe Ile 
            180                 185                 190         


Ser Gln Phe Phe Asp Ala Leu Leu Cys Tyr Tyr Asp Phe Arg Leu Arg 
        195                 200                 205             


Val Asn Met Glu Val Thr Val Met Tyr Phe Leu Tyr Lys Ile Thr Leu 
    210                 215                 220                 


Gly Asn Phe Asn Asn Gln Leu Ile Asn Arg Asn Asp Ile Tyr Asp Asp 
225                 230                 235                 240 


His Ser Glu Glu Gly Lys Gly Gln His Lys Asn Gln Cys Gln Tyr Asp 
                245                 250                 255     


Glu Asn Asp Gln Asn Asp Gln Asn Glu Gln Ser Asp Leu Arg Asp Ile 
            260                 265                 270         


Arg His Met His Asp Lys His Val Lys His Asn Asp Glu Glu Ser Lys 
        275                 280                 285             


Asp Ser Thr Asn Ser Thr Thr Tyr Ile Lys Asn Asn Asn Asn Gln Met 
    290                 295                 300                 


Ser His Ile Asn Asp Leu Ser Ile Thr Asn Asn Met Ser Asp Val His 
305                 310                 315                 320 


Ile Leu Ser Ser Ile Lys Asn Gln Asp Gln Asn Asn Ser Asn Asn Val 
                325                 330                 335     


Ser Ser Met Asp Ser Asn Thr Asn Tyr Met Ser Lys Thr Thr Cys Leu 
            340                 345                 350         


Thr Cys Thr Gly Ser Glu Phe Asn Lys Glu Glu Lys Asp Glu Lys Lys 
        355                 360                 365             


Glu Leu Leu Glu Glu Ala Lys Lys Lys Asp Lys Glu Val Phe Asp Ile 
    370                 375                 380                 


Ser Ile Tyr Asn Ile Met Phe Ile Asp Thr Pro Phe Leu Ile Tyr Phe 
385                 390                 395                 400 


Ile Thr Ala Leu Ile Glu Leu Ala Asn Met Ile Ile Lys Phe Ile Met 
                405                 410                 415     


Ser Phe Tyr Met Phe Tyr Tyr Lys Met Gly Ser Ala Ala Val Leu Asn 
            420                 425                 430         


Gly Ala Leu Leu Ile Ile Ile Met Tyr Gly Leu Met Phe Ala Phe Glu 
        435                 440                 445             


Phe Ser Ser Ser Leu Phe Lys Leu Lys Tyr Leu Lys Tyr Arg Asp Thr 
    450                 455                 460                 


Arg Ile Ser Asn Met His His Ile Leu Lys Glu Phe Lys Leu Met Lys 
465                 470                 475                 480 


Ile Phe Asn Trp Glu Ser Ile Ala Phe Asp Tyr Val Asn Met Phe Arg 
                485                 490                 495     


Ile Lys Glu Met Lys Ile Cys Lys Ile Arg Thr Tyr Leu Ser Ser Leu 
            500                 505                 510         


Ser Asn Tyr Val Asn Asn Ile Ser Val Asn Ile Val Glu Val Ala Ile 
        515                 520                 525             


Phe Phe Phe Tyr Ile Arg Ser Glu Leu Lys Ser Asn Lys Thr Val Ser 
    530                 535                 540                 


Phe Ser Ser Leu Ile Thr Pro Leu Phe Val Tyr Lys Ser Leu Ile Ser 
545                 550                 555                 560 


Gly Val Ser Asn Phe Pro Asn Ile Ile Asn Asn Leu Ile Glu Gly Ala 
                565                 570                 575     


Ile Asn Ile Lys Arg Ile Asn Lys Tyr Ile Asn Tyr Tyr Leu Phe Asn 
            580                 585                 590         


Asn Asp Met Asn Asp Tyr Phe Lys Asn Ser Leu Asn Gly Met Lys Ser 
        595                 600                 605             


Asn Thr Cys Asn Phe Gln Asn Gly Asn Thr Asn Asn Val Asn Gly Tyr 
    610                 615                 620                 


Val Asp Asp Tyr Val Asp Asp Tyr Val Asp Asp Tyr Val Asp Asp Tyr 
625                 630                 635                 640 


Val Asn Asp Tyr Val Asn Asp Tyr Val Asp Asp Tyr Met Asp His Met 
                645                 650                 655     


Met Glu Tyr Asn Ile Asn Ile Asn Ser Lys Asn Gly Cys Ser Ser Lys 
            660                 665                 670         


Ser Arg Lys Asn Asn Lys Ser Phe Ser Lys Asp His Phe Ser Asn His 
        675                 680                 685             


Glu Gln Gly Thr Met Gln Ser Phe Tyr Lys Phe Leu Asp Thr His Lys 
    690                 695                 700                 


Asn Lys Thr Lys Gln Lys Ser Asp Cys Lys Lys Lys Cys Ser Asn Asn 
705                 710                 715                 720 


Gln Leu Ser Lys Ser Asn Asn Asn Asn Val Val Gly Glu Ser Asn Asn 
                725                 730                 735     


Ser Leu Phe Gln Asp Arg Lys Gly Trp Tyr Pro Lys Asn Lys His Phe 
            740                 745                 750         


Lys Asp Asn Ile Val Ile Asn Met Lys Asn Cys Tyr Phe Ser Ser Lys 
        755                 760                 765             


Asn Asn Asp Asp Tyr Ile Leu Lys Asn Ile Asn Leu Thr Leu Lys Asn 
    770                 775                 780                 


Asn Ser Val Val Ile Ile Leu Gly Asn Val Gly Ser Gly Lys Thr Ile 
785                 790                 795                 800 


Phe Phe Tyr Ser Leu Leu Gly Gln Phe Lys Leu Ser Cys Gly Ser Phe 
                805                 810                 815     


Tyr Leu Lys Asn Tyr Ile Tyr Lys Tyr Met Pro Ile Leu Tyr Val Pro 
            820                 825                 830         


Gln Phe Asn Trp Ile Ser Leu Gly Thr Ile Arg Ser Met Ile Leu Phe 
        835                 840                 845             


Gly Asn Lys Tyr Asp Glu Ser Ile Tyr Tyr Asp Val Ile Val Lys Ser 
    850                 855                 860                 


Glu Leu Phe His Asp Ile Ile Ser Phe Lys Lys Lys Asp Met Arg Tyr 
865                 870                 875                 880 


Ile Ser Asp Glu His Ser Leu Ser Lys Gly Gln Lys Ala Arg Ile Cys 
                885                 890                 895     


Leu Ala Arg Ala Leu Tyr His His Tyr Ile His Met Lys His Met Asn 
            900                 905                 910         


Leu Tyr Tyr Gln Lys Asn Glu Leu Ile Asn Glu Lys Met Lys Lys Ile 
        915                 920                 925             


Ser Leu Lys Arg Asp Asp Asn His Thr Ala Gln Arg Ser Asn Asp Asn 
    930                 935                 940                 


Thr Pro Asn Asn Asn Asn Thr Asp Asn Asn Asn Thr Ser Asp Asn Asn 
945                 950                 955                 960 


Asn Thr Ser Asn Asn Asn Asn Thr Ser Asp Asn Asn Asn Thr Ser Asp 
                965                 970                 975     


Asn Asn Asn Thr Ser Asp Asn Asn Asn Thr Ser Asn Asn Asn Asn Thr 
            980                 985                 990         


Asp Asn Asn Asn Thr Ser Asn Asn  Lys Asn Ser Cys Ser  Lys Asn Leu 
        995                 1000                 1005             


Thr Glu  Glu Arg Asn Ile Ser  Tyr Leu Tyr Leu Phe  Asp Asp Leu 
    1010                 1015                 1020             


Phe Thr  Ser Leu Asp Pro Cys  Ile Ser Lys Asp Ile  Phe Tyr Asn 
    1025                 1030                 1035             


Leu Phe  Cys Asp Lys Glu Lys  Ile Gln His Phe Lys  Lys Asn Ser 
    1040                 1045                 1050             


Ser Phe  Ile Leu Ser Ile Ser  Glu Ile Ile Leu Asn  Ser Phe Ile 
    1055                 1060                 1065             


Ser Ser  Asn Cys Ile Leu Asn  Asn Met Gln Tyr Asp  Val Leu Ile 
    1070                 1075                 1080             


Tyr Lys  Leu Glu Asn Ser Thr  Leu His Tyr Glu Gly  Asn Leu Val 
    1085                 1090                 1095             


Asp Tyr  Ile Lys Lys Asn Asn  Ile Val Val Lys Glu  Asp Ile Val 
    1100                 1105                 1110             


Gln Thr  Asn Lys Gln Cys Glu  Lys Lys Ser Leu Thr  Asn Glu Gln 
    1115                 1120                 1125             


Val Lys  Ser Met Leu Ser Leu  Asn Glu Asp Trp Asn  Tyr Met His 
    1130                 1135                 1140             


Arg Val  Lys Lys Lys Ser Ile  Thr Gln Lys Glu Thr  Thr Lys Asn 
    1145                 1150                 1155             


Tyr Asp  Asn Asn Asn Asp Asn  Asn Asn Asp Asn Asn  Asn Asp Asn 
    1160                 1165                 1170             


Asn Asn  Asp Asn Asn Asn Asp  Asn Asn Asn Asp Asn  Asn Asn Asp 
    1175                 1180                 1185             


Asn Asn  Asn Asp Asn Asn Asn  Asn Asn Asn Asn Asn  Asn Val Asn 
    1190                 1195                 1200             


Val Ser  Lys Glu Ile Leu Ser  Cys Glu Ile Lys Thr  Gln Asp His 
    1205                 1210                 1215             


Tyr Asn  Asn Ile His Cys Ser  Lys Thr Asn Phe Glu  Lys His Asn 
    1220                 1225                 1230             


Asn Ser  Ile Tyr Ser Lys Lys  Glu Asn Glu Thr Arg  Lys Ile His 
    1235                 1240                 1245             


Ser Gly  Asp Ile Lys Tyr His  Lys Phe Met Val Leu  Lys Gln Phe 
    1250                 1255                 1260             


Lys Thr  Ile Tyr Ser Phe Lys  Thr Ile Tyr Ser Phe  Asn Thr Glu 
    1265                 1270                 1275             


Glu Thr  Asn Asp Asp Glu Tyr  Asn Lys Thr Tyr Tyr  Arg Lys Tyr 
    1280                 1285                 1290             


Thr Lys  Val Ile Gln Asn Tyr  Asp Asn His Cys Leu  Glu Gly Lys 
    1295                 1300                 1305             


Lys Lys  Ser Phe Arg Asn Tyr  Lys Ser Ile Asn Ser  Tyr Asn Glu 
    1310                 1315                 1320             


Ile Leu  Ile Lys Glu Asn Met  Lys Val Trp Glu Asp  Asp Thr Tyr 
    1325                 1330                 1335             


Tyr Gly  Asn Asp Tyr Ile Asp  Glu Tyr Glu Lys Ile  Lys Lys Asn 
    1340                 1345                 1350             


Val Leu  Ser Lys Leu Lys Tyr  Asn Tyr Tyr Ile Ser  Cys Asp Tyr 
    1355                 1360                 1365             


Asn Asn  Ser Asp His Phe Asp  Phe Asn Glu Glu Leu  Lys Phe Lys 
    1370                 1375                 1380             


Gly Asn  Ile Lys Leu Glu Thr  Phe Trp Trp Tyr Leu  Lys Lys Ile 
    1385                 1390                 1395             


Gly Arg  Pro Leu Ile Ile Val  Ile Ile Ile Phe Met  Leu Leu Ser 
    1400                 1405                 1410             


Ile Phe  Thr Asp Glu Ile Lys  Asn Leu Ile Leu Phe  Leu Ala Ser 
    1415                 1420                 1425             


Thr Ile  Leu Lys Ser Gly Asp  Lys Lys Asp Glu Glu  Ile Leu Asn 
    1430                 1435                 1440             


Gln Gln  Leu Val Tyr Leu Asn  Tyr Phe Ile Leu Leu  Pro Ser Ile 
    1445                 1450                 1455             


Ser Leu  Leu Thr Thr Leu Ile  Ser Phe Met Leu Ile  Ala His Gly 
    1460                 1465                 1470             


Ile Val  Lys Ser Ala Ile Lys  Val His Thr Glu Val  Leu Leu Ser 
    1475                 1480                 1485             


Ile Leu  Tyr Ala Pro Ile His  Ala Phe Tyr Ser Asn  Asn Leu Gly 
    1490                 1495                 1500             


Asn Ile  Ile Asn Lys Phe Ile  Thr Asp Val Asn Ile  Leu Asp Asn 
    1505                 1510                 1515             


Gly Ile  Ile Lys Arg Ile Tyr  Lys Ser Phe Tyr Thr  Leu Phe Arg 
    1520                 1525                 1530             


Phe Leu  Phe Thr Leu Phe Leu  Leu Ile Tyr Met Val  Lys Tyr Thr 
    1535                 1540                 1545             


Ile Val  Ile Phe Pro Phe Ile  Met Leu Ile Ile Tyr  Phe Phe Val 
    1550                 1555                 1560             


Phe Asn  Lys Tyr Ser Lys Gly  Cys Lys Glu Ala Gln  Arg Gly Phe 
    1565                 1570                 1575             


Leu Ala  Ser His Ala Pro Leu  Cys Thr Ile Tyr Ser  Asn Thr Ile 
    1580                 1585                 1590             


Ile Gly  Lys Asp Val Ile Asn  Leu Tyr Lys Lys Asn  Asn Tyr Phe 
    1595                 1600                 1605             


Leu Thr  Leu Tyr Lys Gln Lys  Ile Phe Asp Phe Arg  Asn Tyr Thr 
    1610                 1615                 1620             


Ile Phe  Lys Trp Ser Ile Thr  Ile Trp Ala Ser Leu  Tyr Val Gln 
    1625                 1630                 1635             


Leu Ile  Val Leu Ala Leu Thr  Phe Phe Tyr Ile Ile  Tyr Pro His 
    1640                 1645                 1650             


Phe Phe  Phe Lys His Ala Lys  Gln Asp His Glu Ile  Asn Tyr Glu 
    1655                 1660                 1665             


Lys Glu  Ala Ser Thr Ile Gly  Tyr Cys Ile Thr Phe  Ser Cys Ser 
    1670                 1675                 1680             


Leu Gly  Phe Val Ile Lys Ser  Leu Leu Tyr Asp Tyr  Thr His Val 
    1685                 1690                 1695             


Glu Lys  Glu Met Cys Ser Thr  Gln Arg Leu Glu Glu  Cys Ser Lys 
    1700                 1705                 1710             


Met Ile  Lys Asp Glu Gly Tyr  Ser Asp Asp Asn Ile  Thr Leu Gln 
    1715                 1720                 1725             


Asn Asn  Asp Pro Thr His Glu  Asp Asn Asn Asn Asn  Asn Asn Asn 
    1730                 1735                 1740             


Asn Asn  Asn Glu Gln Asp Ala  Asn Leu Phe Lys Ser  Val Pro Gly 
    1745                 1750                 1755             


Ser Tyr  Asp Pro Asn Asp Lys  Glu Asn Met Arg Lys  Tyr Lys Thr 
    1760                 1765                 1770             


Glu Ile  Val Asn Asn Thr Lys  Asp Met Tyr Ser Ile  Ile Asn Lys 
    1775                 1780                 1785             


Asp Asp  Met Leu Thr His Ser  Ile Asn Asn Lys Asn  Asn Lys Leu 
    1790                 1795                 1800             


Lys Lys  Leu Tyr Thr Ser Pro  His Ile Asp Ile Asn  Lys Ile Lys 
    1805                 1810                 1815             


Tyr Gly  Ile Cys Phe Glu Arg  Val Phe Val Ser Tyr  Lys Lys Lys 
    1820                 1825                 1830             


Ile Cys  Val Asp Arg Lys Asn  Asn Lys Tyr Glu Tyr  Val Asn Glu 
    1835                 1840                 1845             


Lys Ser  Cys Leu Lys Asn Ile  Asn Ile Tyr Ala Leu  Lys Asn Gln 
    1850                 1855                 1860             


Lys Ile  Gly Ile Val Gly Lys  Ser Gly Ala Gly Lys  Ser Thr Met 
    1865                 1870                 1875             


Ile Leu  Ser Ile Leu Gly Leu  Ile Gly Thr Thr Arg  Gly Arg Ile 
    1880                 1885                 1890             


Thr Ile  Glu Gly Gln Asp Ile  Lys Thr Leu Thr Leu  Asp Glu Arg 
    1895                 1900                 1905             


Lys Asn  Met Ile Gly Val Leu  Pro Gln Ser Ser Phe  Val Phe Phe 
    1910                 1915                 1920             


His Trp  Asn Ile Arg Thr Phe  Ile Asp Pro Tyr Lys  Asp Phe Thr 
    1925                 1930                 1935             


Asp Asp  Glu Ile Val Asp Ala  Phe Lys Leu Ile Gly  Ile Asn Leu 
    1940                 1945                 1950             


Ser Tyr  Asp Asp Leu Asp Lys  Tyr Ile Tyr Lys Gln  Gln Arg Gln 
    1955                 1960                 1965             


Gln Gln  Lys Lys Lys Asn Lys  Asn Thr His Asn Leu  Trp Lys Lys 
    1970                 1975                 1980             


Lys Ser  Phe Ile Asp Leu Thr  Asn Ser Ile Ser Leu  Ser Asp Glu 
    1985                 1990                 1995             


Cys Ile  Arg Tyr Leu Ser Leu  Val Arg Leu Phe Leu  Asn Arg His 
    2000                 2005                 2010             


Lys Tyr  Lys Leu Ile Leu Ile  Asp Glu Ile Pro Val  Leu Asn Phe 
    2015                 2020                 2025             


Cys Tyr  Asn Thr Lys Lys Leu  Thr Asn Phe Phe Thr  Thr Asp Ile 
    2030                 2035                 2040             


Lys Ser  Phe Asp Tyr Ile Ile  Arg Thr Phe Phe Gln  Asn Thr Thr 
    2045                 2050                 2055             


Val Leu  Ile Ile Ala His Asp  Ala Ser Thr Leu Ser  Cys Cys Asp 
    2060                 2065                 2070             


Phe Ile  Tyr Val Ile Ala Lys  Gly Glu Val Val Tyr  Lys Cys Ser 
    2075                 2080                 2085             


Tyr Lys  Asp Val Lys Thr Gln  Thr Glu Leu Ala Asn  Leu Leu Gln 
    2090                 2095                 2100             


Glu Lys  Gln Leu Asn 
    2105             


<210>  20
<211>  6327
<212>  DNA
<213>  Plasmodium falciparum

<400>  20
atgatgagac ggagaagcgt ttacaatttc gatcaaggaa aacatggcta tttaatgaat     60

catatatctt ggcttaattt tgtgagtttc aattggatta cacaactttt aagatgtctt    120

aagaatgatg attttgtatt accttgtata gaagaaacaa gttccataga acattatagc    180

acgaacctaa ataggaatgt tcgaaatatt caattaagaa aatataataa atataataaa    240

tataagaatt attgttgtag taaatataat gatggtaata aaagttgtag ttgctctaca    300

aagaatcata caaataaatt tcataaaaga aaaaaggaag atcatttttt aaaaagtagt    360

ggtattacat atgcagtttt gaaaacattt aaatattatt taagtttaat tagtttcttt    420

catattatac ataccatatt tctaatattt gttgctgtgt gtattgagaa atatgtcttg    480

ttaatcaaag gcggttcaaa tgttgtaact ctaccatttg gattcaaaaa ttctaaagtg    540

ttgttcggat ttatagtcat ttcagtaata ttcattagtc agttttttga tgccctcctt    600

tgctattatg attttagatt aagagtaaat atggaggtca ccgttatgta ttttttatac    660

aaaataacgt taggcaattt caacaatcag ttgattaata gaaacgatat atatgatgac    720

catagtgaag agggaaaggg ccaacataaa aatcaatgtc aatatgatga aaatgatcag    780

aatgatcaga atgagcaaag cgatttacgt gatatacgac atatgcatga taaacatgtc    840

aaacataatg atgaagaaag caaagattca accaacagta cgacatatat caaaaataat    900

aacaatcaaa tgagccacat aaacgatttg tcaattacaa ataatatgtc cgatgtacat    960

attttatcga gcataaaaaa ccaagatcag aataacagta ataatgtttc gagcatggat   1020

agcaacacca attacatgag caaaacgaca tgtttaacgt gtacaggctc cgaatttaat   1080

aaagaagaaa aagatgagaa aaaagaactt ttagaagaag cgaaaaagaa agataaagaa   1140

gtattcgata ttagtatata taatataatg tttatagata caccattttt aatttatttt   1200

ataacagcat taatagaatt agcaaatatg ataataaaat ttataatgtc attttatatg   1260

ttttattata aaatgggtag tgcagctgta ttaaacggtg ctttgttaat tataataatg   1320

tatggattaa tgtttgcttt tgaattttca tccagtttat ttaaattgaa atatttaaaa   1380

tatcgtgata caagaataag taatatgcat catatattaa aagaattcaa attaatgaaa   1440

atatttaatt gggaatctat agcttttgat tatgtaaata tgtttcgaat aaaagaaatg   1500

aaaatatgta aaatcagaac ctatttaagt tctttaagta attatgttaa taatatatct   1560

gtaaatattg tagaagttgc tattttcttt ttttacataa gaagtgaatt aaagagtaat   1620

aaaaccgtca gcttcagttc tttaatcaca cccctttttg tttataaatc tttaatttct   1680

ggtgtatcta attttccaaa tataattaat aatttaatag aaggtgctat aaatattaag   1740

cgtattaata aatatataaa ctattatttg tttaacaatg atatgaatga ttattttaag   1800

aattcattga acggtatgaa aagtaatacg tgtaactttc aaaatggtaa caccaacaat   1860

gtgaatggtt atgtggatga ttatgtggat gattatgtgg atgattatgt ggatgattat   1920

gtgaatgatt atgtgaatga ttatgtggat gattatatgg atcatatgat ggagtataat   1980

ataaatatca atagtaaaaa tggttgttcc tccaaatcaa gaaagaacaa caaatcattt   2040

tcaaaagatc atttttcaaa tcatgaacaa gggacgatgc aaagttttta caaatttttg   2100

gatacacaca aaaataaaac aaaacaaaaa agcgattgta aaaaaaaatg tagtaataat   2160

caattatcca agagtaacaa taataatgtt gtaggtgaaa gtaataattc actatttcaa   2220

gacagaaaag ggtggtatcc aaaaaataaa cattttaaag ataatatagt gataaatatg   2280

aagaattgtt atttttcatc gaaaaataat gatgattata tattaaaaaa tataaactta   2340

acattaaaaa ataatagtgt agttattata cttgggaatg tgggttcagg aaaaaccatt   2400

ttcttctatt cattattagg tcaatttaaa ttatcatgtg gtagttttta tttaaaaaat   2460

tatatatata agtatatgcc tattttatat gtaccacaat ttaattggat atccttaggt   2520

actatcagat ctatgatatt gttcggaaat aagtatgatg aatctattta ttatgatgtc   2580

atcgtaaaaa gtgaattatt tcatgatata atatccttta agaaaaagga catgagatat   2640

ataagtgatg aacatagttt gagtaaagga caaaaagcta ggatatgttt agctagagca   2700

ttgtatcatc attatataca tatgaaacat atgaatttat attatcagaa aaatgaatta   2760

ataaatgaaa aaatgaagaa aatatcttta aaaagagatg ataatcatac tgcacagagg   2820

tctaatgata acacgccaaa taataataac acagataata ataacacgtc agataataat   2880

aacacgtcaa ataataataa cacatcagat aataataaca catcagataa taataacaca   2940

tcagataata ataacacgtc aaataataat aacacagata ataataacac atcaaataat   3000

aaaaatagtt gtagtaaaaa ccttacagaa gaaaggaata tatcttatct ttatcttttt   3060

gatgatttgt tcacctctct agatccttgt atatccaaag atatctttta taatttattt   3120

tgtgataaag aaaagataca acattttaaa aaaaacagtt catttatttt atccataagc   3180

gaaattatat taaatagttt tatttcaagt aattgtattc ttaacaacat gcaatatgat   3240

gtgttaatat ataaattaga aaacagtaca ttacattatg agggcaattt agtagattat   3300

ataaaaaaaa ataatatagt agtaaaagaa gatatcgttc aaacgaataa acaatgtgaa   3360

aaaaaaagtt taacaaatga acaagtcaaa tctatgttaa gtcttaatga agattggaac   3420

tatatgcacc gtgtaaaaaa aaaaagcatc acccaaaaag aaactaccaa aaattatgat   3480

aataataatg ataacaataa tgataataat aatgataaca ataatgataa caataatgat   3540

aacaataatg ataacaataa tgataacaat aatgataaca ataataataa taacaataat   3600

aatgttaatg ttagtaagga aatactctca tgtgaaataa aaactcaaga tcattataat   3660

aatattcatt gtagtaaaac caattttgag aaacataata atagtattta tagtaagaaa   3720

gaaaatgaga ccagaaaaat acacagcgga gatataaaat accacaaatt tatggttctt   3780

aaacaattta aaacaatcta ttcctttaaa accatttact cgttcaatac agaagaaact   3840

aatgatgatg aatataacaa aacttattat aggaaatata ctaaagtgat ccagaattat   3900

gataatcatt gtttagaagg aaaaaagaaa agttttagaa attataaaag cattaatagt   3960

tataatgaaa tattaattaa agagaatatg aaagtttggg aagatgatac atattatgga   4020

aatgattata tagatgaata tgaaaaaata aaaaagaatg ttttatctaa attaaaatat   4080

aattattata tatcttgtga ttataataac agtgatcatt ttgattttaa tgaagaatta   4140

aaatttaaag gaaatatcaa gttagaaaca ttttggtggt atttaaaaaa aattggaaga   4200

cctctaatta ttgttattat tatatttatg ttactttcta tatttacaga tgaaatcaaa   4260

aatttaatat tatttttagc tagtactata ttaaagagtg gtgataagaa agatgaagaa   4320

attttgaatc aacaattagt ttatttaaat tattttattt tattaccatc aatatcttta   4380

ttaacaacat taatttcttt tatgttaata gcacatggta ttgttaaatc ggctattaaa   4440

gtacatacag aagtattgct tagtatatta tatgccccta tacatgcatt ttatagtaat   4500

aatttaggaa atataattaa taaatttata acagatgtta atatattaga taatggaatt   4560

attaaaagaa tttataaatc tttttataca ctctttcgct ttttatttac actcttttta   4620

ttaatatata tggttaaata tactattgtt atatttccat ttattatgtt aattatatat   4680

ttttttgtat ttaataaata ttcgaaagga tgtaaagaag cacaaagagg atttttagca   4740

tcacatgcac ccttatgtac aatatatagt aatactatta taggaaagga tgttatcaat   4800

ttatataaaa aaaataatta tttcttaaca ttatataaac aaaaaatatt tgattttaga   4860

aattatacta tatttaagtg gtcaataact atatgggcat ctttatacgt acaattaatt   4920

gttctggcgc taaccttctt ttatatcata tatccacatt tcttttttaa acacgcaaaa   4980

caagaccatg aaatcaacta tgaaaaagaa gctagtacga taggttattg tattaccttt   5040

tcatgtagcc ttggttttgt tataaaaagc ttattgtatg actacaccca tgtagaaaag   5100

gaaatgtgta gtacacaaag attagaagaa tgctccaaga tgattaaaga cgaaggttat   5160

tctgatgata atataacttt gcaaaataat gaccctaccc acgaagataa taataataat   5220

aataataata ataataatga gcaggatgca aatttattta aatctgttcc tggttcgtat   5280

gatccgaatg ataaagaaaa tatgagaaaa tacaaaacag aaattgttaa taatacaaaa   5340

gatatgtatt ctattataaa taaggatgat atgttaacac attcaattaa taataagaat   5400

aataaattaa aaaaattata taccagtcct catatagata ttaataaaat aaagtatggt   5460

atctgtttcg aaagagtatt tgttagctat aaaaagaaaa tttgtgttga tagaaaaaat   5520

aataaatatg aatatgtaaa tgaaaaatca tgcttaaaaa atatcaatat atatgcttta   5580

aaaaatcaga aaattggtat cgtaggaaaa tcaggagcag gaaaaagtac tatgatacta   5640

tctattctag gtttaatagg tactactaga ggaagaatta ctattgaagg acaagatata   5700

aaaaccttaa cgttagatga aagaaaaaat atgattggtg tattaccaca atcatctttt   5760

gtattttttc attggaatat tagaacattt atagatccat ataaagattt tactgatgat   5820

gaaattgttg atgctttcaa attaatagga attaatttaa gttatgatga tttagataaa   5880

tatatttata aacaacaacg acaacaacaa aaaaaaaaaa ataaaaatac acataattta   5940

tggaaaaaaa aaagttttat tgatttaacg aactctatat ctttatcaga tgaatgtatt   6000

agatatttat cattagtacg tcttttttta aatagacata aatataaact cattttaatc   6060

gatgaaatac ctgtacttaa tttctgttat aataccaaaa aattaaccaa cttctttaca   6120

acagatatta aatcttttga ttatattatt agaacattct ttcaaaatac tacagtcctc   6180

attattgctc atgatgcaag tacactctca tgttgtgatt ttatttacgt tatcgcaaag   6240

ggagaagttg tatacaaatg tagttataaa gatgttaaaa cacaaaccga attagctaac   6300

ttgcttcaag aaaaacaatt aaattga                                       6327


