                         SEQUENCE LISTING

<110>  UCB Biopharma SPRL
 
<120>  Multimeric Fc Proteins

<130>  G0217

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tailpiece IgM

<400>  1

Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr 
1               5                   10                  15      


Cys Tyr 
        


<210>  2
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tailpiece IgA

<400>  2

Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr 
1               5                   10                  15      


Cys Tyr 
        


<210>  3
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Human IgA1

<400>  3

Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro 
1               5                   10                  15      


Ser Pro Ser 
            


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Human IgA2

<400>  4

Val Pro Pro Pro Pro Pro 
1               5       


<210>  5
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Human IgD

<400>  5

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro 
    50                  55              


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Human IgG1

<400>  6

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Human IgG2

<400>  7

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  8
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Human IgG3

<400>  8

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Human IgG4

<400>  9

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Human IgG4(P)

<400>  10

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v1

<400>  11

Cys Pro Pro Cys 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v2

<400>  12

Cys Pro Ser Cys 
1               


<210>  13
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v3

<400>  13

Cys Pro Arg Cys 
1               


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v4

<400>  14

Ser Pro Pro Cys 
1               


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v5

<400>  15

Cys Pro Pro Ser 
1               


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v6

<400>  16

Ser Pro Pro Ser 
1               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v7

<400>  17

Asp Lys Thr His Thr Cys Ala Ala 
1               5               


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v8

<400>  18

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10      


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v9

<400>  19

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  20
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v10

<400>  20

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  21
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v11

<400>  21

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr Leu 
1               5                   10                  15      


Tyr Asn Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            20                  25                  30  


<210>  22
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v12

<400>  22

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
            20                  25                  30      


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v13

<400>  23

Asp Lys Thr His Thr Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15  


<210>  24
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v14

<400>  24

Asp Lys Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
            20                  25      


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Recombinant v15

<400>  25

Asp Lys Thr His Thr Cys Pro Ser Cys Pro Ala 
1               5                   10      


<210>  26
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc-multimer IgM tp

<400>  26

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  27
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 Fc-multimer IgM tp

<400>  27

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  28
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc-multimer IgA tp

<400>  28

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr 
    210                 215                 220                 


His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  29
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 Fc-multimer IgA tp

<400>  29

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Thr 
    210                 215                 220                 


His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  30
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc-multimer C 4-IgM tp

<400>  30

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Ala 
    210                 215                 220                 


Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg Glu Gln Leu 
225                 230                 235                 240 


Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr Gly Phe Ser 
                245                 250                 255     


Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln Pro Leu Ser 
            260                 265                 270         


Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro Gln Ala Pro 
        275                 280                 285             


Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu Glu Glu Trp 
    290                 295                 300                 


Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His Glu Ala Leu Pro Asn 
305                 310                 315                 320 


Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly Lys Pro Thr Leu 
                325                 330                 335     


Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            340                 345                 350     


<210>  31
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 Fc-multimer C 4-IgM tp

<400>  31

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Val Ala 
    210                 215                 220                 


Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg Glu Gln Leu 
225                 230                 235                 240 


Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr Gly Phe Ser 
                245                 250                 255     


Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln Pro Leu Ser 
            260                 265                 270         


Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro Gln Ala Pro 
        275                 280                 285             


Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu Glu Glu Trp 
    290                 295                 300                 


Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His Glu Ala Leu Pro Asn 
305                 310                 315                 320 


Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly Lys Pro Thr Leu 
                325                 330                 335     


Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            340                 345                 350     


<210>  32
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc-multimer IgM tp S267A

<400>  32

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ala His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  33
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc IgM tp

<400>  33

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  34
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc IgM tp

<400>  34

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  35
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc IgM tp L234F

<400>  35

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  36
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc IgM tp L234F P331S

<400>  36

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  37
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc IgM tp F234L

<400>  37

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  38
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc IgM tp F234L F296Y

<400>  38

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  39
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc IgM tp G327A S330A

<400>  39

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  40
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc IgM tp G327A S331P

<400>  40

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  41
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc IgM tp S330A S331P

<400>  41

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  42
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 CH2 IgG4 CH3 IgM tp

<400>  42

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  43
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 CH2 IgG1 CH3 IgM tp

<400>  43

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  44
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 CH2 / IgG1 CH3 hybrid F234L

<400>  44

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  45
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 CH2 / IgG1 CH3 hybrid G327A S331P

<400>  45

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  46
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 CH2 / IgG1 CH3 hybrid F234L F296Y

<400>  46

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  47
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 CH2 / IgG1 CH3 hybrid G327A S330A

<400>  47

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Pro Thr 
    210                 215                 220                 


Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 235                 240 


<210>  48
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B72.3 signal peptide

<400>  48
atggaatggt cctgggtctt cctgtttttc ctttctgtca caaccggggt gcacagc          57


<210>  49
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B72.3 signal peptide

<400>  49

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  50
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc IgM tp L309

<400>  50
tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca       60

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      120

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      180

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      240

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      300

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa      360

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg      420

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg      480

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc      540

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc      600

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg      660

ggtaaaccga ccctgtataa cgtgagcctg gtgatgagcg ataccgcggg cacctgctat      720


<210>  51
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc IgM tp L309

<400>  51
tgtccacctt gtccagctcc tgagtttctt ggcggtcctt ctgtgttcct cttccctcca       60

aagcctaagg acaccctgat gatctccaga acaccagaag tgacctgcgt ggtagtggat      120

gttagccagg aagaccctga ggtccagttc aactggtatg tggacggcgt tgaggtccat      180

aacgccaaaa ccaagccacg agaggagcag ttcaactcaa cctaccgtgt ggtgtctgtg      240

ctcactgtcc tgcatcagga ttggctgaac ggcaaggagt acaagtgcaa ggtcagcaac      300

aagggactgc caagctccat cgagaagacc attagcaaag ccaagggtca gcctagggaa      360

ccacaggtgt atacattgcc tccctcacag gaggagatga ccaagaacca ggtcagtctg      420

acatgcctgg tgaaagggtt ctatccctcc gatatcgcag tcgaatggga aagcaatggc      480

cagcctgaga acaactacaa aaccactcca cccgtccttg atagcgatgg cagtttcttc      540

ctgtacagcc gtctgactgt ggataagtct cgatggcagg agggtaacgt attcagctgc      600

agcgtcatgc atgaagcctt gcacaaccac tacacccaga aatccctgtc tctgtcactc      660

gggaagccga ccctgtataa cgtgagcctg gtgatgagcg ataccgcggg cacctgctat      720


<210>  52
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc IgM tp L309 L234F P331S

<400>  52
tgcccaccgt gcccagcacc tgaattcctg gggggaccgt cagtcttcct cttcccccca       60

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      120

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      180

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      240

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      300

aaagccctcc cagccagcat cgagaaaacc atctccaaag ccaaagggca gccccgagaa      360

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg      420

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg      480

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc      540

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc      600

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg      660

ggtaaaccga ccctgtataa cgtgagcctg gtgatgagcg ataccgcggg cacctgctat      720


<210>  53
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hybrid Fc IgG4-CH2 IgG1-CH3 IgM tp L309

<400>  53
tgcccaccgt gcccagcacc tgagttcctg gggggaccat cagtcttcct gttcccccca       60

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      120

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat      180

aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgtaccgtgt ggtcagcgtc      240

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac      300

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa      360

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg      420

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg      480

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc      540

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc      600

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg      660

ggtaaaccga ccctgtataa cgtgagcctg gtgatgagcg ataccgcggg cacctgctat      720


<210>  54
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc IgM tp L309 F234L

<400>  54
tgtccacctt gtccagctcc tgagttactt ggcggtcctt ctgtgttcct cttccctcca       60

aagcctaagg acaccctgat gatctccaga acaccagaag tgacctgcgt ggtagtggat      120

gttagccagg aagaccctga ggtccagttc aactggtatg tggacggcgt tgaggtccat      180

aacgccaaaa ccaagccacg agaggagcag ttcaactcaa cctaccgtgt ggtgtctgtg      240

ctcactgtcc tgcatcagga ttggctgaac ggcaaggagt acaagtgcaa ggtcagcaac      300

aagggactgc caagctccat cgagaagacc attagcaaag ccaagggtca gcctagggaa      360

ccacaggtgt atacattgcc tccctcacag gaggagatga ccaagaacca ggtcagtctg      420

acatgcctgg tgaaagggtt ctatccctcc gatatcgcag tcgaatggga aagcaatggc      480

cagcctgaga acaactacaa aaccactcca cccgtccttg atagcgatgg cagtttcttc      540

ctgtacagcc gtctgactgt ggataagtct cgatggcagg agggtaacgt attcagctgc      600

agcgtcatgc atgaagcctt gcacaaccac tacacccaga aatccctgtc tctgtcactc      660

gggaagccga ccctgtataa cgtgagcctg gtgatgagcg ataccgcggg cacctgctat      720


<210>  55
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc IgM tp L309 F234L F296Y

<400>  55
tgtccacctt gtccagctcc tgagttactt ggcggtcctt ctgtgttcct cttccctcca       60

aagcctaagg acaccctgat gatctccaga acaccagaag tgacctgcgt ggtagtggat      120

gttagccagg aagaccctga ggtccagttc aactggtatg tggacggcgt tgaggtccat      180

aacgccaaaa ccaagccacg agaggagcag tataactcaa cctaccgtgt ggtgtctgtg      240

ctcactgtcc tgcatcagga ttggctgaac ggcaaggagt acaagtgcaa ggtcagcaac      300

aagggactgc caagctccat cgagaagacc attagcaaag ccaagggtca gcctagggaa      360

ccacaggtgt atacattgcc tccctcacag gaggagatga ccaagaacca ggtcagtctg      420

acatgcctgg tgaaagggtt ctatccctcc gatatcgcag tcgaatggga aagcaatggc      480

cagcctgaga acaactacaa aaccactcca cccgtccttg atagcgatgg cagtttcttc      540

ctgtacagcc gtctgactgt ggataagtct cgatggcagg agggtaacgt attcagctgc      600

agcgtcatgc atgaagcctt gcacaaccac tacacccaga aatccctgtc tctgtcactc      660

gggaagccga ccctgtataa cgtgagcctg gtgatgagcg ataccgcggg cacctgctat      720


<210>  56
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc IgM tp L309 G327A S330A

<400>  56
tgtccacctt gtccagctcc tgagtttctt ggcggtcctt ctgtgttcct cttccctcca       60

aagcctaagg acaccctgat gatctccaga acaccagaag tgacctgcgt ggtagtggat      120

gttagccagg aagaccctga ggtccagttc aactggtatg tggacggcgt tgaggtccat      180

aacgccaaaa ccaagccacg agaggagcag ttcaactcaa cctaccgtgt ggtgtctgtg      240

ctcactgtcc tgcatcagga ttggctgaac ggcaaggagt acaagtgcaa ggtcagcaac      300

aaggcactgc cagcctccat cgagaagacc attagcaaag ccaagggtca gcctagggaa      360

ccacaggtgt atacattgcc tccctcacag gaggagatga ccaagaacca ggtcagtctg      420

acatgcctgg tgaaagggtt ctatccctcc gatatcgcag tcgaatggga aagcaatggc      480

cagcctgaga acaactacaa aaccactcca cccgtccttg atagcgatgg cagtttcttc      540

ctgtacagcc gtctgactgt ggataagtct cgatggcagg agggtaacgt attcagctgc      600

agcgtcatgc atgaagcctt gcacaaccac tacacccaga aatccctgtc tctgtcactc      660

gggaagccga ccctgtataa cgtgagcctg gtgatgagcg ataccgcggg cacctgctat      720


<210>  57
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc IgM tp L309 G327A S331P

<400>  57
tgtccacctt gtccagctcc tgagtttctt ggcggtcctt ctgtgttcct cttccctcca       60

aagcctaagg acaccctgat gatctccaga acaccagaag tgacctgcgt ggtagtggat      120

gttagccagg aagaccctga ggtccagttc aactggtatg tggacggcgt tgaggtccat      180

aacgccaaaa ccaagccacg agaggagcag ttcaactcaa cctaccgtgt ggtgtctgtg      240

ctcactgtcc tgcatcagga ttggctgaac ggcaaggagt acaagtgcaa ggtcagcaac      300

aaggcactgc caagccccat cgagaagacc attagcaaag ccaagggtca gcctagggaa      360

ccacaggtgt atacattgcc tccctcacag gaggagatga ccaagaacca ggtcagtctg      420

acatgcctgg tgaaagggtt ctatccctcc gatatcgcag tcgaatggga aagcaatggc      480

cagcctgaga acaactacaa aaccactcca cccgtccttg atagcgatgg cagtttcttc      540

ctgtacagcc gtctgactgt ggataagtct cgatggcagg agggtaacgt attcagctgc      600

agcgtcatgc atgaagcctt gcacaaccac tacacccaga aatccctgtc tctgtcactc      660

gggaagccga ccctgtataa cgtgagcctg gtgatgagcg ataccgcggg cacctgctat      720


<210>  58
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc IgM tp L309 S330A S331P

<400>  58
tgtccacctt gtccagctcc tgagtttctt ggcggtcctt ctgtgttcct cttccctcca       60

aagcctaagg acaccctgat gatctccaga acaccagaag tgacctgcgt ggtagtggat      120

gttagccagg aagaccctga ggtccagttc aactggtatg tggacggcgt tgaggtccat      180

aacgccaaaa ccaagccacg agaggagcag ttcaactcaa cctaccgtgt ggtgtctgtg      240

ctcactgtcc tgcatcagga ttggctgaac ggcaaggagt acaagtgcaa ggtcagcaac      300

aagggactgc cagcccccat cgagaagacc attagcaaag ccaagggtca gcctagggaa      360

ccacaggtgt atacattgcc tccctcacag gaggagatga ccaagaacca ggtcagtctg      420

acatgcctgg tgaaagggtt ctatccctcc gatatcgcag tcgaatggga aagcaatggc      480

cagcctgaga acaactacaa aaccactcca cccgtccttg atagcgatgg cagtttcttc      540

ctgtacagcc gtctgactgt ggataagtct cgatggcagg agggtaacgt attcagctgc      600

agcgtcatgc atgaagcctt gcacaaccac tacacccaga aatccctgtc tctgtcactc      660

gggaagccga ccctgtataa cgtgagcctg gtgatgagcg ataccgcggg cacctgctat      720


<210>  59
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 CH2-IgG1 CH3 IgM tp L309 F234L F296Y

<400>  59
tgcccaccgt gcccagcacc tgagttactg gggggaccat cagtcttcct gttcccccca       60

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      120

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat      180

aatgccaaga caaagccgcg ggaggagcag tataacagca cgtaccgtgt ggtcagcgtc      240

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac      300

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa      360

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg      420

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg      480

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc      540

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc      600

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg      660

ggtaaaccga ccctgtataa cgtgagcctg gtgatgagcg ataccgcggg cacctgctat      720


