                         SEQUENCE LISTING

<110>  North Carolina State University
       Lewis, Ramsey E.
       Dewey, Ralph E.
 
<120>  TOBACCO INBRED AND HYBRID PLANTS AND TOBACCO PRODUCTS MADE
       THEREOF

<130>  P34123US02

<150>  US 61/946,993
<151>  2014-03-03

<150>  US 61/947,004
<151>  2014-03-03

<150>  US 61/947,013
<151>  2014-03-03

<150>  US 61/978,244
<151>  2014-04-11

<150>  US 61/978,246
<151>  2014-04-11

<150>  US 61/978,326
<151>  2014-04-11

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1554
<212>  DNA
<213>  Nicotiana tabacum


<220>
<221>  Mutation
<222>  (986)..(986)
<223>  G to A

<400>  1
atgctttctc ccatagaagc cattgtagga ctagtaacct tcacatttct cttcttcttc       60

ctatggacaa aaaaatctca aaaaccttca aaacccttac caccgaaaat ccccggagga      120

tggccggtaa tcggccatct tttccacttc aatgacgacg gcgacgaccg tccattagct      180

cgaaaactcg gagacttagc tgacaaatac ggccccgttt tcacttttcg gctaggcctt      240

ccccttgtct tagttgtaag cagttacgaa gctgtaaaag actgtttctc tacaaatgac      300

gccatttttt ccaatcgtcc agcttttctt tacggcgatt accttggcta caataatgcc      360

atgctatttt tggccaatta cggaccttac tggcgaaaaa atcgaaaatt agttattcag      420

gaagttctct ccgctagtcg tctcgaaaaa ttcaaacacg tgagatttgc aagaattcaa      480

gcgagcatta agaatttata tactcgaatt gatggaaatt cgagtacgat aaatttaact      540

gattggttag aagaattgaa ttttggtctg atcgtgaaga tgatcgctgg aaaaaattat      600

gaatccggta aaggagatga acaagtggag agatttaaga aagcgtttaa ggattttatg      660

attttatcaa tggagtttgt gttatgggat gcatttccaa ttccattatt taaatgggtg      720

gattttcaag ggcatgttaa ggctatgaaa aggactttta aagatataga ttctgttttt      780

cagaattggt tagaggaaca tattaataaa agagaaaaaa tggaggttaa tgcagaaggg      840

aatgaacaag atttcattga tgtggtgctt tcaaaaatga gtaatgaata tcttggtgaa      900

ggttactctc gtgatactgt cattaaagca acggtgttta gtttggtctt ggatgcagca      960

gacacagttg ctcttcacat aaattaggga atggcattat tgataaacaa tcaaaaggcc     1020

ttgacgaaag cacaagaaga gatagacaca aaagttggta aggacagatg ggtagaagag     1080

agtgatatta aggatttggt atacctccaa gctattgtta aagaagtgtt acgattatat     1140

ccaccaggac ctttgttagt accacacgaa aatgtagaag attgtgttgt tagtggatat     1200

cacattccta aagggacaag attattcgca aacgtcatga aactgcaacg tgatcctaaa     1260

ctctggtctg atcctgatac tttcgatcca gagagattca ttgctactga tattgacttt     1320

cgtggtcagt actataagta tatcccgttt ggttctggaa gacgatcttg tccagggatg     1380

acttatgcat tgcaagtgga acacttaaca atggcacatt tgatccaagg tttcaattac     1440

agaactccaa atgacgagcc cttggatatg aaggaaggtg caggcataac tatacgtaag     1500

gtaaatcctg tggaactgat aatagcgcct cgcctggcac ctgagcttta ttaa           1554


<210>  2
<211>  1554
<212>  DNA
<213>  Nicotiana tabacum


<220>
<221>  Mutation
<222>  (1266)..(1266)
<223>  G to A

<400>  2
atggtttctc ccgtagaagc cattgtagga ctagtaaccc ttacacttct cttctacttc       60

ctatggccca aaaaatttca aataccttca aaaccattac caccgaaaat tcccggaggg      120

tggccggtaa tcggccatct tttctacttc gatgatgacg gcgacgaccg tccattagct      180

cgaaaactcg gagacttagc tgacaaatac ggcccggttt tcactttccg gctaggcctt      240

ccgcttgtgt tagttgtaag cagttacgaa gctgtaaaag actgcttctc tacaaatgac      300

gccattttct ccaatcgtcc agcttttctt tacggtgaat accttggcta cagtaatgcc      360

atgctatttt tgacaaaata cggaccttat tggcgaaaaa atagaaaatt agtcattcag      420

gaagttctct ctgctagtcg tctcgaaaaa ttgaagcacg tgagatttgg taaaattcaa      480

acgagcatta agagtttata cactcgaatt gatggaaatt cgagtacgat aaatctaact      540

gattggttag aagaattgaa ttttggtctg atcgtgaaaa tgatcgctgg gaaaaattat      600

gaatccggta aaggagatga acaagtggag agatttagga aagcgtttaa ggattttata      660

attttatcaa tggagtttgt gttatgggat gcttttccaa ttccattgtt caaatgggtg      720

gattttcaag gccatgttaa ggccatgaaa aggacattta aggatataga ttctgttttt      780

cagaattggt tagaggaaca tgtcaagaaa agagaaaaaa tggaggttaa tgcacaaggg      840

aatgaacaag atttcattga tgtggtgctt tcaaaaatga gtaatgaata tcttgatgaa      900

ggttactctc gtgatactgt cataaaagca acagtgttta gtttggtctt ggatgctgcg      960

gacacagttg ctcttcacat gaattgggga atggcattac tgataaacaa tcaacatgcc     1020

ttgaagaaag cacaagaaga gatcgataaa aaagttggta aggaaagatg ggtagaagag     1080

agtgatatta aggatttggt ctacctccaa gctattgtta aagaagtgtt acgattatat     1140

ccaccaggac ctttattagt acctcatgaa aatgtagagg attgtgttgt tagtggatat     1200

cacattccta aagggactag actattcgcg aacgttatga aattgcagcg cgatcctaaa     1260

ctctgatcaa atcctgataa gtttgatcca gagagattct tcgctgatga tattgactac     1320

cgtggtcagc actatgagtt tatcccattt ggttctggaa gacgatcttg tccggggatg     1380

acttatgcat tacaagtgga acacctaaca atagcacatt tgatccaggg tttcaattac     1440

aaaactccaa atgacgagcc cttggatatg aaggaaggtg caggattaac tatacgtaaa     1500

gtaaatcctg tagaagtgac aattacggct cgcctggcac ctgagcttta ttaa           1554


<210>  3
<211>  328
<212>  PRT
<213>  Nicotiana tabacum

<400>  3

Met Leu Ser Pro Ile Glu Ala Ile Val Gly Leu Val Thr Phe Thr Phe 
1               5                   10                  15      


Leu Phe Phe Phe Leu Trp Thr Lys Lys Ser Gln Lys Pro Ser Lys Pro 
            20                  25                  30          


Leu Pro Pro Lys Ile Pro Gly Gly Trp Pro Val Ile Gly His Leu Phe 
        35                  40                  45              


His Phe Asn Asp Asp Gly Asp Asp Arg Pro Leu Ala Arg Lys Leu Gly 
    50                  55                  60                  


Asp Leu Ala Asp Lys Tyr Gly Pro Val Phe Thr Phe Arg Leu Gly Leu 
65                  70                  75                  80  


Pro Leu Val Leu Val Val Ser Ser Tyr Glu Ala Val Lys Asp Cys Phe 
                85                  90                  95      


Ser Thr Asn Asp Ala Ile Phe Ser Asn Arg Pro Ala Phe Leu Tyr Gly 
            100                 105                 110         


Asp Tyr Leu Gly Tyr Asn Asn Ala Met Leu Phe Leu Ala Asn Tyr Gly 
        115                 120                 125             


Pro Tyr Trp Arg Lys Asn Arg Lys Leu Val Ile Gln Glu Val Leu Ser 
    130                 135                 140                 


Ala Ser Arg Leu Glu Lys Phe Lys His Val Arg Phe Ala Arg Ile Gln 
145                 150                 155                 160 


Ala Ser Ile Lys Asn Leu Tyr Thr Arg Ile Asp Gly Asn Ser Ser Thr 
                165                 170                 175     


Ile Asn Leu Thr Asp Trp Leu Glu Glu Leu Asn Phe Gly Leu Ile Val 
            180                 185                 190         


Lys Met Ile Ala Gly Lys Asn Tyr Glu Ser Gly Lys Gly Asp Glu Gln 
        195                 200                 205             


Val Glu Arg Phe Lys Lys Ala Phe Lys Asp Phe Met Ile Leu Ser Met 
    210                 215                 220                 


Glu Phe Val Leu Trp Asp Ala Phe Pro Ile Pro Leu Phe Lys Trp Val 
225                 230                 235                 240 


Asp Phe Gln Gly His Val Lys Ala Met Lys Arg Thr Phe Lys Asp Ile 
                245                 250                 255     


Asp Ser Val Phe Gln Asn Trp Leu Glu Glu His Ile Asn Lys Arg Glu 
            260                 265                 270         


Lys Met Glu Val Asn Ala Glu Gly Asn Glu Gln Asp Phe Ile Asp Val 
        275                 280                 285             


Val Leu Ser Lys Met Ser Asn Glu Tyr Leu Gly Glu Gly Tyr Ser Arg 
    290                 295                 300                 


Asp Thr Val Ile Lys Ala Thr Val Phe Ser Leu Val Leu Asp Ala Ala 
305                 310                 315                 320 


Asp Thr Val Ala Leu His Ile Asn 
                325             


<210>  4
<211>  421
<212>  PRT
<213>  Nicotiana tabacum

<400>  4

Met Val Ser Pro Val Glu Ala Ile Val Gly Leu Val Thr Leu Thr Leu 
1               5                   10                  15      


Leu Phe Tyr Phe Leu Trp Pro Lys Lys Phe Gln Ile Pro Ser Lys Pro 
            20                  25                  30          


Leu Pro Pro Lys Ile Pro Gly Gly Trp Pro Val Ile Gly His Leu Phe 
        35                  40                  45              


Tyr Phe Asp Asp Asp Gly Asp Asp Arg Pro Leu Ala Arg Lys Leu Gly 
    50                  55                  60                  


Asp Leu Ala Asp Lys Tyr Gly Pro Val Phe Thr Phe Arg Leu Gly Leu 
65                  70                  75                  80  


Pro Leu Val Leu Val Val Ser Ser Tyr Glu Ala Val Lys Asp Cys Phe 
                85                  90                  95      


Ser Thr Asn Asp Ala Ile Phe Ser Asn Arg Pro Ala Phe Leu Tyr Gly 
            100                 105                 110         


Glu Tyr Leu Gly Tyr Ser Asn Ala Met Leu Phe Leu Thr Lys Tyr Gly 
        115                 120                 125             


Pro Tyr Trp Arg Lys Asn Arg Lys Leu Val Ile Gln Glu Val Leu Ser 
    130                 135                 140                 


Ala Ser Arg Leu Glu Lys Leu Lys His Val Arg Phe Gly Lys Ile Gln 
145                 150                 155                 160 


Thr Ser Ile Lys Ser Leu Tyr Thr Arg Ile Asp Gly Asn Ser Ser Thr 
                165                 170                 175     


Ile Asn Leu Thr Asp Trp Leu Glu Glu Leu Asn Phe Gly Leu Ile Val 
            180                 185                 190         


Lys Met Ile Ala Gly Lys Asn Tyr Glu Ser Gly Lys Gly Asp Glu Gln 
        195                 200                 205             


Val Glu Arg Phe Arg Lys Ala Phe Lys Asp Phe Ile Ile Leu Ser Met 
    210                 215                 220                 


Glu Phe Val Leu Trp Asp Ala Phe Pro Ile Pro Leu Phe Lys Trp Val 
225                 230                 235                 240 


Asp Phe Gln Gly His Val Lys Ala Met Lys Arg Thr Phe Lys Asp Ile 
                245                 250                 255     


Asp Ser Val Phe Gln Asn Trp Leu Glu Glu His Val Lys Lys Arg Glu 
            260                 265                 270         


Lys Met Glu Val Asn Ala Gln Gly Asn Glu Gln Asp Phe Ile Asp Val 
        275                 280                 285             


Val Leu Ser Lys Met Ser Asn Glu Tyr Leu Asp Glu Gly Tyr Ser Arg 
    290                 295                 300                 


Asp Thr Val Ile Lys Ala Thr Val Phe Ser Leu Val Leu Asp Ala Ala 
305                 310                 315                 320 


Asp Thr Val Ala Leu His Met Asn Trp Gly Met Ala Leu Leu Ile Asn 
                325                 330                 335     


Asn Gln His Ala Leu Lys Lys Ala Gln Glu Glu Ile Asp Lys Lys Val 
            340                 345                 350         


Gly Lys Glu Arg Trp Val Glu Glu Ser Asp Ile Lys Asp Leu Val Tyr 
        355                 360                 365             


Leu Gln Ala Ile Val Lys Glu Val Leu Arg Leu Tyr Pro Pro Gly Pro 
    370                 375                 380                 


Leu Leu Val Pro His Glu Asn Val Glu Asp Cys Val Val Ser Gly Tyr 
385                 390                 395                 400 


His Ile Pro Lys Gly Thr Arg Leu Phe Ala Asn Val Met Lys Leu Gln 
                405                 410                 415     


Arg Asp Pro Lys Leu 
            420     


<210>  5
<211>  1554
<212>  DNA
<213>  Nicotiana tabacum

<400>  5
atgctttctc ccatagaagc cattgtagga ctagtaacct tcacatttct cttcttcttc       60

ctatggacaa aaaaatctca aaaaccttca aaacccttac caccgaaaat ccccggagga      120

tggccggtaa tcggccatct tttccacttc aatgacgacg gcgacgaccg tccattagct      180

cgaaaactcg gagacttagc tgacaaatac ggccccgttt tcacttttcg gctaggcctt      240

ccccttgtct tagttgtaag cagttacgaa gctgtaaaag actgtttctc tacaaatgac      300

gccatttttt ccaatcgtcc agcttttctt tacggcgatt accttggcta caataatgcc      360

atgctatttt tggccaatta cggaccttac tggcgaaaaa atcgaaaatt agttattcag      420

gaagttctct ccgctagtcg tctcgaaaaa ttcaaacacg tgagatttgc aagaattcaa      480

gcgagcatta agaatttata tactcgaatt gatggaaatt cgagtacgat aaatttaact      540

gattggttag aagaattgaa ttttggtctg atcgtgaaga tgatcgctgg aaaaaattat      600

gaatccggta aaggagatga acaagtggag agatttaaga aagcgtttaa ggattttatg      660

attttatcaa tggagtttgt gttatgggat gcatttccaa ttccattatt taaatgggtg      720

gattttcaag ggcatgttaa ggctatgaaa aggactttta aagatataga ttctgttttt      780

cagaattggt tagaggaaca tattaataaa agagaaaaaa tggaggttaa tgcagaaggg      840

aatgaacaag atttcattga tgtggtgctt tcaaaaatga gtaatgaata tcttggtgaa      900

ggttactctc gtgatactgt cattaaagca acggtgttta gtttggtctt ggatgcagca      960

gacacagttg ctcttcacat aaattgggga atggcattat tgataaacaa tcaaaaggcc     1020

ttgacgaaag cacaagaaga gatagacaca aaagttggta aggacagatg ggtagaagag     1080

agtgatatta aggatttggt atacctccaa gctattgtta aagaagtgtt acgattatat     1140

ccaccaggac ctttgttagt accacacgaa aatgtagaag attgtgttgt tagtggatat     1200

cacattccta aagggacaag attattcgca aacgtcatga aactgcaacg tgatcctaaa     1260

ctctggtctg atcctgatac tttcgatcca gagagattca ttgctactga tattgacttt     1320

cgtggtcagt actataagta tatcccgttt ggttctggaa gacgatcttg tccagggatg     1380

acttatgcat tgcaagtgga acacttaaca atggcacatt tgatccaagg tttcaattac     1440

agaactccaa atgacgagcc cttggatatg aaggaaggtg caggcataac tatacgtaag     1500

gtaaatcctg tggaactgat aatagcgcct cgcctggcac ctgagcttta ttaa           1554


<210>  6
<211>  1554
<212>  DNA
<213>  Nicotiana tabacum

<400>  6
atggtttctc ccgtagaagc cattgtagga ctagtaaccc ttacacttct cttctacttc       60

ctatggccca aaaaatttca aataccttca aaaccattac caccgaaaat tcccggaggg      120

tggccggtaa tcggccatct tttctacttc gatgatgacg gcgacgaccg tccattagct      180

cgaaaactcg gagacttagc tgacaaatac ggcccggttt tcactttccg gctaggcctt      240

ccgcttgtgt tagttgtaag cagttacgaa gctgtaaaag actgcttctc tacaaatgac      300

gccattttct ccaatcgtcc agcttttctt tacggtgaat accttggcta cagtaatgcc      360

atgctatttt tgacaaaata cggaccttat tggcgaaaaa atagaaaatt agtcattcag      420

gaagttctct ctgctagtcg tctcgaaaaa ttgaagcacg tgagatttgg taaaattcaa      480

acgagcatta agagtttata cactcgaatt gatggaaatt cgagtacgat aaatctaact      540

gattggttag aagaattgaa ttttggtctg atcgtgaaaa tgatcgctgg gaaaaattat      600

gaatccggta aaggagatga acaagtggag agatttagga aagcgtttaa ggattttata      660

attttatcaa tggagtttgt gttatgggat gcttttccaa ttccattgtt caaatgggtg      720

gattttcaag gccatgttaa ggccatgaaa aggacattta aggatataga ttctgttttt      780

cagaattggt tagaggaaca tgtcaagaaa agagaaaaaa tggaggttaa tgcacaaggg      840

aatgaacaag atttcattga tgtggtgctt tcaaaaatga gtaatgaata tcttgatgaa      900

ggttactctc gtgatactgt cataaaagca acagtgttta gtttggtctt ggatgctgcg      960

gacacagttg ctcttcacat gaattgggga atggcattac tgataaacaa tcaacatgcc     1020

ttgaagaaag cacaagaaga gatcgataaa aaagttggta aggaaagatg ggtagaagag     1080

agtgatatta aggatttggt ctacctccaa gctattgtta aagaagtgtt acgattatat     1140

ccaccaggac ctttattagt acctcatgaa aatgtagagg attgtgttgt tagtggatat     1200

cacattccta aagggactag actattcgcg aacgttatga aattgcagcg cgatcctaaa     1260

ctctggtcaa atcctgataa gtttgatcca gagagattct tcgctgatga tattgactac     1320

cgtggtcagc actatgagtt tatcccattt ggttctggaa gacgatcttg tccggggatg     1380

acttatgcat tacaagtgga acacctaaca atagcacatt tgatccaggg tttcaattac     1440

aaaactccaa atgacgagcc cttggatatg aaggaaggtg caggattaac tatacgtaaa     1500

gtaaatcctg tagaagtgac aattacggct cgcctggcac ctgagcttta ttaa           1554


<210>  7
<211>  517
<212>  PRT
<213>  Nicotiana tabacum

<400>  7

Met Leu Ser Pro Ile Glu Ala Ile Val Gly Leu Val Thr Phe Thr Phe 
1               5                   10                  15      


Leu Phe Phe Phe Leu Trp Thr Lys Lys Ser Gln Lys Pro Ser Lys Pro 
            20                  25                  30          


Leu Pro Pro Lys Ile Pro Gly Gly Trp Pro Val Ile Gly His Leu Phe 
        35                  40                  45              


His Phe Asn Asp Asp Gly Asp Asp Arg Pro Leu Ala Arg Lys Leu Gly 
    50                  55                  60                  


Asp Leu Ala Asp Lys Tyr Gly Pro Val Phe Thr Phe Arg Leu Gly Leu 
65                  70                  75                  80  


Pro Leu Val Leu Val Val Ser Ser Tyr Glu Ala Val Lys Asp Cys Phe 
                85                  90                  95      


Ser Thr Asn Asp Ala Ile Phe Ser Asn Arg Pro Ala Phe Leu Tyr Gly 
            100                 105                 110         


Asp Tyr Leu Gly Tyr Asn Asn Ala Met Leu Phe Leu Ala Asn Tyr Gly 
        115                 120                 125             


Pro Tyr Trp Arg Lys Asn Arg Lys Leu Val Ile Gln Glu Val Leu Ser 
    130                 135                 140                 


Ala Ser Arg Leu Glu Lys Phe Lys His Val Arg Phe Ala Arg Ile Gln 
145                 150                 155                 160 


Ala Ser Ile Lys Asn Leu Tyr Thr Arg Ile Asp Gly Asn Ser Ser Thr 
                165                 170                 175     


Ile Asn Leu Thr Asp Trp Leu Glu Glu Leu Asn Phe Gly Leu Ile Val 
            180                 185                 190         


Lys Met Ile Ala Gly Lys Asn Tyr Glu Ser Gly Lys Gly Asp Glu Gln 
        195                 200                 205             


Val Glu Arg Phe Lys Lys Ala Phe Lys Asp Phe Met Ile Leu Ser Met 
    210                 215                 220                 


Glu Phe Val Leu Trp Asp Ala Phe Pro Ile Pro Leu Phe Lys Trp Val 
225                 230                 235                 240 


Asp Phe Gln Gly His Val Lys Ala Met Lys Arg Thr Phe Lys Asp Ile 
                245                 250                 255     


Asp Ser Val Phe Gln Asn Trp Leu Glu Glu His Ile Asn Lys Arg Glu 
            260                 265                 270         


Lys Met Glu Val Asn Ala Glu Gly Asn Glu Gln Asp Phe Ile Asp Val 
        275                 280                 285             


Val Leu Ser Lys Met Ser Asn Glu Tyr Leu Gly Glu Gly Tyr Ser Arg 
    290                 295                 300                 


Asp Thr Val Ile Lys Ala Thr Val Phe Ser Leu Val Leu Asp Ala Ala 
305                 310                 315                 320 


Asp Thr Val Ala Leu His Ile Asn Trp Gly Met Ala Leu Leu Ile Asn 
                325                 330                 335     


Asn Gln Lys Ala Leu Thr Lys Ala Gln Glu Glu Ile Asp Thr Lys Val 
            340                 345                 350         


Gly Lys Asp Arg Trp Val Glu Glu Ser Asp Ile Lys Asp Leu Val Tyr 
        355                 360                 365             


Leu Gln Ala Ile Val Lys Glu Val Leu Arg Leu Tyr Pro Pro Gly Pro 
    370                 375                 380                 


Leu Leu Val Pro His Glu Asn Val Glu Asp Cys Val Val Ser Gly Tyr 
385                 390                 395                 400 


His Ile Pro Lys Gly Thr Arg Leu Phe Ala Asn Val Met Lys Leu Gln 
                405                 410                 415     


Arg Asp Pro Lys Leu Trp Ser Asp Pro Asp Thr Phe Asp Pro Glu Arg 
            420                 425                 430         


Phe Ile Ala Thr Asp Ile Asp Phe Arg Gly Gln Tyr Tyr Lys Tyr Ile 
        435                 440                 445             


Pro Phe Gly Ser Gly Arg Arg Ser Cys Pro Gly Met Thr Tyr Ala Leu 
    450                 455                 460                 


Gln Val Glu His Leu Thr Met Ala His Leu Ile Gln Gly Phe Asn Tyr 
465                 470                 475                 480 


Arg Thr Pro Asn Asp Glu Pro Leu Asp Met Lys Glu Gly Ala Gly Ile 
                485                 490                 495     


Thr Ile Arg Lys Val Asn Pro Val Glu Leu Ile Ile Ala Pro Arg Leu 
            500                 505                 510         


Ala Pro Glu Leu Tyr 
        515         


<210>  8
<211>  517
<212>  PRT
<213>  Nicotiana tabacum

<400>  8

Met Leu Ser Pro Ile Glu Ala Ile Val Gly Leu Val Thr Phe Thr Phe 
1               5                   10                  15      


Leu Phe Phe Phe Leu Trp Thr Lys Lys Ser Gln Lys Pro Ser Lys Pro 
            20                  25                  30          


Leu Pro Pro Lys Ile Pro Gly Gly Trp Pro Val Ile Gly His Leu Phe 
        35                  40                  45              


His Phe Asn Asp Asp Gly Asp Asp Arg Pro Leu Ala Arg Lys Leu Gly 
    50                  55                  60                  


Asp Leu Ala Asp Lys Tyr Gly Pro Val Phe Thr Phe Arg Leu Gly Leu 
65                  70                  75                  80  


Pro Leu Val Leu Val Val Ser Ser Tyr Glu Ala Val Lys Asp Cys Phe 
                85                  90                  95      


Ser Thr Asn Asp Ala Ile Phe Ser Asn Arg Pro Ala Phe Leu Tyr Gly 
            100                 105                 110         


Asp Tyr Leu Gly Tyr Asn Asn Ala Met Leu Phe Leu Ala Asn Tyr Gly 
        115                 120                 125             


Pro Tyr Trp Arg Lys Asn Arg Lys Leu Val Ile Gln Glu Val Leu Ser 
    130                 135                 140                 


Ala Ser Arg Leu Glu Lys Phe Lys His Val Arg Phe Ala Arg Ile Gln 
145                 150                 155                 160 


Ala Ser Ile Lys Asn Leu Tyr Thr Arg Ile Asp Gly Asn Ser Ser Thr 
                165                 170                 175     


Ile Asn Leu Thr Asp Trp Leu Glu Glu Leu Asn Phe Gly Leu Ile Val 
            180                 185                 190         


Lys Met Ile Ala Gly Lys Asn Tyr Glu Ser Gly Lys Gly Asp Glu Gln 
        195                 200                 205             


Val Glu Arg Phe Lys Lys Ala Phe Lys Asp Phe Met Ile Leu Ser Met 
    210                 215                 220                 


Glu Phe Val Leu Trp Asp Ala Phe Pro Ile Pro Leu Phe Lys Trp Val 
225                 230                 235                 240 


Asp Phe Gln Gly His Val Lys Ala Met Lys Arg Thr Phe Lys Asp Ile 
                245                 250                 255     


Asp Ser Val Phe Gln Asn Trp Leu Glu Glu His Ile Asn Lys Arg Glu 
            260                 265                 270         


Lys Met Glu Val Asn Ala Glu Gly Asn Glu Gln Asp Phe Ile Asp Val 
        275                 280                 285             


Val Leu Ser Lys Met Ser Asn Glu Tyr Leu Gly Glu Gly Tyr Ser Arg 
    290                 295                 300                 


Asp Thr Val Ile Lys Ala Thr Val Phe Ser Leu Val Leu Asp Ala Ala 
305                 310                 315                 320 


Asp Thr Val Ala Leu His Ile Asn Trp Gly Met Ala Leu Leu Ile Asn 
                325                 330                 335     


Asn Gln Lys Ala Leu Thr Lys Ala Gln Glu Glu Ile Asp Thr Lys Val 
            340                 345                 350         


Gly Lys Asp Arg Trp Val Glu Glu Ser Asp Ile Lys Asp Leu Val Tyr 
        355                 360                 365             


Leu Gln Ala Ile Val Lys Glu Val Leu Arg Leu Tyr Pro Pro Gly Pro 
    370                 375                 380                 


Leu Leu Val Pro His Glu Asn Val Glu Asp Cys Val Val Ser Gly Tyr 
385                 390                 395                 400 


His Ile Pro Lys Gly Thr Arg Leu Phe Ala Asn Val Met Lys Leu Gln 
                405                 410                 415     


Arg Asp Pro Lys Leu Trp Ser Asp Pro Asp Thr Phe Asp Pro Glu Arg 
            420                 425                 430         


Phe Ile Ala Thr Asp Ile Asp Phe Arg Gly Gln Tyr Tyr Lys Tyr Ile 
        435                 440                 445             


Pro Phe Gly Ser Gly Arg Arg Ser Cys Pro Gly Met Thr Tyr Ala Leu 
    450                 455                 460                 


Gln Val Glu His Leu Thr Met Ala His Leu Ile Gln Gly Phe Asn Tyr 
465                 470                 475                 480 


Arg Thr Pro Asn Asp Glu Pro Leu Asp Met Lys Glu Gly Ala Gly Ile 
                485                 490                 495     


Thr Ile Arg Lys Val Asn Pro Val Glu Leu Ile Ile Ala Pro Arg Leu 
            500                 505                 510         


Ala Pro Glu Leu Tyr 
        515         


<210>  9
<211>  1554
<212>  DNA
<213>  Nicotiana tabacum

<400>  9
atggtttctc ccgtagaagc catcgtagga ctagtaactc ttacacttct cttctacttc       60

atacggacca aaaaatctca aaaaccttca aaaccattac caccgaaaat ccccggaggg      120

tggccggtaa tcggccatct tttctatttc gatgacgaca gcgacgaccg tccattagca      180

cgaaaactcg gagacttagc tgacaaatac ggcccggttt tcacttttcg gctaggcctt      240

ccgcttgtgt tagttgtaag cagttacgaa gctataaaag actgcttctc tacaaatgat      300

gccattttct ccaatcgtcc agcttttctt tatggcgaat accttggcta caataatgcc      360

atgctatttt tgacaaaata cggaccttac tggcgaaaaa atagaaaatt agtcattcag      420

gaagttctct gtgctagtcg tctcgaaaaa ttgaagcacg tgagatttgg tgaaattcag      480

acgagcatta agaatttata cactcgaatt gatggaaatt cgagtacgat aaatctaacc      540

gattggttag aagaattgaa ttttggtctg atcgtgaaaa tgatcgctgg gaaaaattat      600

gaatccggta aaggagatga acaagtggag agatttagga aagcgtttaa ggattttata      660

attttatcaa tggagtttgt gttatgggat gcttttccaa ttccattgtt caaatgggtg      720

gattttcaag gccatgttaa ggccatgaaa aggacattta aggatataga ttctgttttt      780

cagaattggt tagaggaaca tgtcaagaaa aaagaaaaaa tggaggttaa tgcagaagga      840

aatgaacaag atttcattga tgtggtgctt tcaaaaatga gtaatgaata tcttgatgaa      900

ggctactctc gtgatactgt cataaaagca acagtgttta gtttagtctt ggatgctgcg      960

gacacagttg ctcttcacat gaattgggga atggcattat tgataaacaa tcaacatgcc     1020

ttgaagaaag cgcaagaaga gatagataaa aaagttggta aggatagatg ggtagaagag     1080

agtgatatta aggatttggt atacctccaa actattgtta aagaagtgtt acgattatat     1140

ccaccgggac ctttattagt accccatgaa aatgtagagg attgtgttgt tagtggatat     1200

cacattccta aagggactag actattcgcg aacgttatga aattacagcg cgatcctaaa     1260

ctctggtcaa atcctgataa gttcgatcca gagagatttt tcgctgctga tattgacttt     1320

cgtggtcaac actatgagtt tatcccattt ggttctggaa gacgatcttg tccggggatg     1380

acttatgcaa tgcaagtgga acacctaaca atcgcacact tgatccaggg tttcaattac     1440

aaaactccaa atgacgagcc cttggatatg aaggaaggtg caggattaac tatacgtaag     1500

gtaaatccta tagaagtggt aattacgcct cgcctgacac ctgagcttta ttaa           1554


<210>  10
<211>  517
<212>  PRT
<213>  Nicotiana tabacum

<400>  10

Met Val Ser Pro Val Glu Ala Ile Val Gly Leu Val Thr Leu Thr Leu 
1               5                   10                  15      


Leu Phe Tyr Phe Ile Arg Thr Lys Lys Ser Gln Lys Pro Ser Lys Pro 
            20                  25                  30          


Leu Pro Pro Lys Ile Pro Gly Gly Trp Pro Val Ile Gly His Leu Phe 
        35                  40                  45              


Tyr Phe Asp Asp Asp Ser Asp Asp Arg Pro Leu Ala Arg Lys Leu Gly 
    50                  55                  60                  


Asp Leu Ala Asp Lys Tyr Gly Pro Val Phe Thr Phe Arg Leu Gly Leu 
65                  70                  75                  80  


Pro Leu Val Leu Val Val Ser Ser Tyr Glu Ala Ile Lys Asp Cys Phe 
                85                  90                  95      


Ser Thr Asn Asp Ala Ile Phe Ser Asn Arg Pro Ala Phe Leu Tyr Gly 
            100                 105                 110         


Glu Tyr Leu Gly Tyr Asn Asn Ala Met Leu Phe Leu Thr Lys Tyr Gly 
        115                 120                 125             


Pro Tyr Trp Arg Lys Asn Arg Lys Leu Val Ile Gln Glu Val Leu Cys 
    130                 135                 140                 


Ala Ser Arg Leu Glu Lys Leu Lys His Val Arg Phe Gly Glu Ile Gln 
145                 150                 155                 160 


Thr Ser Ile Lys Asn Leu Tyr Thr Arg Ile Asp Gly Asn Ser Ser Thr 
                165                 170                 175     


Ile Asn Leu Thr Asp Trp Leu Glu Glu Leu Asn Phe Gly Leu Ile Val 
            180                 185                 190         


Lys Met Ile Ala Gly Lys Asn Tyr Glu Ser Gly Lys Gly Asp Glu Gln 
        195                 200                 205             


Val Glu Arg Phe Arg Lys Ala Phe Lys Asp Phe Ile Ile Leu Ser Met 
    210                 215                 220                 


Glu Phe Val Leu Trp Asp Ala Phe Pro Ile Pro Leu Phe Lys Trp Val 
225                 230                 235                 240 


Asp Phe Gln Gly His Val Lys Ala Met Lys Arg Thr Phe Lys Asp Ile 
                245                 250                 255     


Asp Ser Val Phe Gln Asn Trp Leu Glu Glu His Val Lys Lys Lys Glu 
            260                 265                 270         


Lys Met Glu Val Asn Ala Glu Gly Asn Glu Gln Asp Phe Ile Asp Val 
        275                 280                 285             


Val Leu Ser Lys Met Ser Asn Glu Tyr Leu Asp Glu Gly Tyr Ser Arg 
    290                 295                 300                 


Asp Thr Val Ile Lys Ala Thr Val Phe Ser Leu Val Leu Asp Ala Ala 
305                 310                 315                 320 


Asp Thr Val Ala Leu His Met Asn Trp Gly Met Ala Leu Leu Ile Asn 
                325                 330                 335     


Asn Gln His Ala Leu Lys Lys Ala Gln Glu Glu Ile Asp Lys Lys Val 
            340                 345                 350         


Gly Lys Asp Arg Trp Val Glu Glu Ser Asp Ile Lys Asp Leu Val Tyr 
        355                 360                 365             


Leu Gln Thr Ile Val Lys Glu Val Leu Arg Leu Tyr Pro Pro Gly Pro 
    370                 375                 380                 


Leu Leu Val Pro His Glu Asn Val Glu Asp Cys Val Val Ser Gly Tyr 
385                 390                 395                 400 


His Ile Pro Lys Gly Thr Arg Leu Phe Ala Asn Val Met Lys Leu Gln 
                405                 410                 415     


Arg Asp Pro Lys Leu Trp Ser Asn Pro Asp Lys Phe Asp Pro Glu Arg 
            420                 425                 430         


Phe Phe Ala Ala Asp Ile Asp Phe Arg Gly Gln His Tyr Glu Phe Ile 
        435                 440                 445             


Pro Phe Gly Ser Gly Arg Arg Ser Cys Pro Gly Met Thr Tyr Ala Met 
    450                 455                 460                 


Gln Val Glu His Leu Thr Ile Ala His Leu Ile Gln Gly Phe Asn Tyr 
465                 470                 475                 480 


Lys Thr Pro Asn Asp Glu Pro Leu Asp Met Lys Glu Gly Ala Gly Leu 
                485                 490                 495     


Thr Ile Arg Lys Val Asn Pro Ile Glu Val Val Ile Thr Pro Arg Leu 
            500                 505                 510         


Thr Pro Glu Leu Tyr 
        515         


<210>  11
<211>  1554
<212>  DNA
<213>  Nicotiana tabacum


<220>
<221>  Mutation
<222>  (1141)..(1141)
<223>  C to T

<400>  11
atggtttctc ccgtagaagc catcgtagga ctagtaactc ttacacttct cttctacttc       60

atacggacca aaaaatctca aaaaccttca aaaccattac caccgaaaat ccccggaggg      120

tggccggtaa tcggccatct tttctatttc gatgacgaca gcgacgaccg tccattagca      180

cgaaaactcg gagacttagc tgacaaatac ggcccggttt tcacttttcg gctaggcctt      240

ccgcttgtgt tagttgtaag cagttacgaa gctataaaag actgcttctc tacaaatgat      300

gccattttct ccaatcgtcc agcttttctt tatggcgaat accttggcta caataatgcc      360

atgctatttt tgacaaaata cggaccttac tggcgaaaaa atagaaaatt agtcattcag      420

gaagttctct gtgctagtcg tctcgaaaaa ttgaagcacg tgagatttgg tgaaattcag      480

acgagcatta agaatttata cactcgaatt gatggaaatt cgagtacgat aaatctaacc      540

gattggttag aagaattgaa ttttggtctg atcgtgaaaa tgatcgctgg gaaaaattat      600

gaatccggta aaggagatga acaagtggag agatttagga aagcgtttaa ggattttata      660

attttatcaa tggagtttgt gttatgggat gcttttccaa ttccattgtt caaatgggtg      720

gattttcaag gccatgttaa ggccatgaaa aggacattta aggatataga ttctgttttt      780

cagaattggt tagaggaaca tgtcaagaaa aaagaaaaaa tggaggttaa tgcagaagga      840

aatgaacaag atttcattga tgtggtgctt tcaaaaatga gtaatgaata tcttgatgaa      900

ggctactctc gtgatactgt cataaaagca acagtgttta gtttagtctt ggatgctgcg      960

gacacagttg ctcttcacat gaattgggga atggcattat tgataaacaa tcaacatgcc     1020

ttgaagaaag cgcaagaaga gatagataaa aaagttggta aggatagatg ggtagaagag     1080

agtgatatta aggatttggt atacctccaa actattgtta aagaagtgtt acgattatat     1140

tcaccgggac ctttattagt accccatgaa aatgtagagg attgtgttgt tagtggatat     1200

cacattccta aagggactag actattcgcg aacgttatga aattacagcg cgatcctaaa     1260

ctctggtcaa atcctgataa gttcgatcca gagagatttt tcgctgctga tattgacttt     1320

cgtggtcaac actatgagtt tatcccattt ggttctggaa gacgatcttg tccggggatg     1380

acttatgcaa tgcaagtgga acacctaaca atcgcacact tgatccaggg tttcaattac     1440

aaaactccaa atgacgagcc cttggatatg aaggaaggtg caggattaac tatacgtaag     1500

gtaaatccta tagaagtggt aattacgcct cgcctgacac ctgagcttta ttaa           1554


<210>  12
<211>  571
<212>  PRT
<213>  Nicotiana tabacum

<400>  12

Met Val Ser Pro Val Glu Ala Ile Val Gly Leu Val Thr Leu Thr Leu 
1               5                   10                  15      


Leu Phe Tyr Phe Ile Arg Thr Lys Lys Ser Gln Lys Pro Ser Lys Pro 
            20                  25                  30          


Leu Pro Pro Lys Ile Pro Gly Gly Trp Pro Val Ile Gly His Leu Phe 
        35                  40                  45              


Tyr Phe Asp Asp Asp Ser Asp Asp Arg Pro Leu Ala Arg Lys Leu Gly 
    50                  55                  60                  


Asp Leu Ala Asp Lys Tyr Gly Pro Val Phe Thr Phe Arg Leu Gly Leu 
65                  70                  75                  80  


Pro Leu Val Leu Val Val Ser Ser Tyr Glu Ala Ile Lys Asp Cys Phe 
                85                  90                  95      


Ser Thr Asn Asp Ala Ile Phe Ser Asn Arg Pro Ala Phe Leu Tyr Gly 
            100                 105                 110         


Glu Tyr Leu Gly Tyr Asn Asn Ala Met Leu Phe Leu Thr Lys Tyr Gly 
        115                 120                 125             


Pro Tyr Trp Arg Lys Asn Arg Lys Leu Val Ile Gln Glu Val Leu Cys 
    130                 135                 140                 


Ala Ser Arg Leu Glu Lys Leu Lys His Val Arg Phe Gly Glu Ile Gln 
145                 150                 155                 160 


Thr Ser Ile Lys Asn Leu Tyr Thr Arg Ile Asp Gly Asn Ser Ser Thr 
                165                 170                 175     


Ile Asn Leu Thr Asp Trp Leu Glu Glu Leu Asn Phe Gly Leu Ile Val 
            180                 185                 190         


Lys Met Ile Ala Gly Lys Asn Tyr Glu Ser Gly Lys Gly Asp Glu Gln 
        195                 200                 205             


Val Glu Arg Phe Arg Lys Ala Phe Lys Asp Phe Ile Ile Leu Ser Met 
    210                 215                 220                 


Glu Phe Val Leu Trp Asp Ala Phe Pro Ile Pro Leu Phe Lys Trp Val 
225                 230                 235                 240 


Asp Phe Gln Gly His Val Lys Ala Met Lys Arg Thr Phe Lys Asp Ile 
                245                 250                 255     


Asp Ser Val Phe Gln Asn Trp Leu Glu Glu His Val Lys Lys Lys Glu 
            260                 265                 270         


Lys Met Glu Val Asn Ala Glu Gly Asn Glu Gln Asp Phe Ile Asp Val 
        275                 280                 285             


Val Leu Ser Lys Met Ser Asn Glu Tyr Leu Asp Glu Gly Tyr Ser Arg 
    290                 295                 300                 


Asp Thr Val Ile Lys Ala Thr Val Phe Ser Leu Val Leu Asp Ala Ala 
305                 310                 315                 320 


Asp Thr Val Ala Leu His Met Asn Trp Gly Met Ala Leu Leu Ile Asn 
                325                 330                 335     


Asn Gln His Ala Leu Lys Lys Ala Gln Glu Glu Ile Asp Lys Lys Val 
            340                 345                 350         


Gly Lys Asp Arg Trp Val Glu Glu Ser Asp Ile Lys Asp Leu Val Tyr 
        355                 360                 365             


Leu Gln Thr Ile Val Lys Glu Val Leu Arg Leu Tyr Ser Pro Gly Pro 
    370                 375                 380                 


Leu Leu Val Pro His Glu Asn Val Glu Asp Cys Val Val Ser Gly Tyr 
385                 390                 395                 400 


His Ile Pro Lys Gly Thr Arg Leu Phe Ala Asn Val Met Lys Leu Gln 
                405                 410                 415     


Arg Asp Pro Lys Leu Trp Ser Asn Pro Asp Lys Phe Asp Pro Glu Arg 
            420                 425                 430         


Phe Phe Ala Ala Asp Ile Asp Phe Arg Gly Gln His Tyr Glu Phe Ile 
        435                 440                 445             


Pro Phe Gly Ser Gly Arg Arg Ser Cys Pro Gly Met Thr Tyr Ala Met 
    450                 455                 460                 


Gln Val Glu His Leu Thr Ile Ala His Leu Ile Gln Gly Phe Asn Tyr 
465                 470                 475                 480 


Lys Thr Pro Asn Asp Glu Pro Leu Asp Met Lys Glu Gly Ala Gly Leu 
                485                 490                 495     


Thr Ile Arg Lys Val Asn Pro Ile Glu Val Val Ile Thr Pro Arg Leu 
            500                 505                 510         


Thr Pro Glu Leu Tyr Gly Thr Ala Ala Ala Thr Cys Cys Thr Ala Thr 
        515                 520                 525             


Ala Gly Ala Ala Gly Thr Gly Gly Thr Ala Ala Thr Thr Ala Cys Gly 
    530                 535                 540                 


Cys Cys Thr Cys Gly Cys Cys Thr Gly Ala Cys Ala Cys Cys Thr Gly 
545                 550                 555                 560 


Ala Gly Cys Thr Thr Thr Ala Thr Thr Ala Ala 
                565                 570     


