                         SEQUENCE LISTING

<110>  Cellectis
 
<120>  METHOD FOR GENERATING T-CELLS COMPATIBLE FOR ALLOGENIC 
       TRANSPLANTATION

<130>  P81400799PCT00

<150>  PA 201470119
<151>  2014-03-11

<160>  97    

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  2
<211>  6673
<212>  DNA
<213>  Homo sapiens

<400>  2
aatataagtg gaggcgtcgc gctggcgggc attcctgaag ctgacagcat tcgggccgag       60

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggct      120

atccagcgtg agtctctcct accctcccgc tctggtcctt cctctcccgc tctgcaccct      180

ctgtggccct cgctgtgctc tctcgctccg tgacttccct tctccaagtt ctccttggtg      240

gcccgccgtg gggctagtcc agggctggat ctcggggaag cggcggggtg gcctgggagt      300

ggggaagggg gtgcgcaccc gggacgcgcg ctacttgccc ctttcggcgg ggagcagggg      360

agacctttgg cctacggcga cgggagggtc gggacaaagt ttagggcgtc gataagcgtc      420

agagcgccga ggttggggga gggtttctct tccgctcttt cgcggggcct ctggctcccc      480

cagcgcagct ggagtggggg acgggtaggc tcgtcccaaa ggcgcggcgc tgaggtttgt      540

gaacgcgtgg aggggcgctt ggggtctggg ggaggcgtcg cccgggtaag cctgtctgct      600

gcggctctgc ttcccttaga ctggagagct gtggacttcg tctaggcgcc cgctaagttc      660

gcatgtccta gcacctctgg gtctatgtgg ggccacaccg tggggaggaa acagcacgcg      720

acgtttgtag aatgcttggc tgtgatacaa agcggtttcg aataattaac ttatttgttc      780

ccatcacatg tcacttttaa aaaattataa gaactacccg ttattgacat ctttctgtgt      840

gccaaggact ttatgtgctt tgcgtcattt aattttgaaa acagttatct tccgccatag      900

ataactacta tggttatctt ctgcctctca cagatgaaga aactaaggca ccgagatttt      960

aagaaactta attacacagg ggataaatgg cagcaatcga gattgaagtc aagcctaacc     1020

agggcttttg cgggagcgca tgccttttgg ctgtaattcg tgcatttttt tttaagaaaa     1080

acgcctgcct tctgcgtgag attctccaga gcaaactggg cggcatgggc cctgtggtct     1140

tttcgtacag agggcttcct ctttggctct ttgcctggtt gtttccaaga tgtactgtgc     1200

ctcttacttt cggttttgaa aacatgaggg ggttgggcgt ggtagcttac gcctgtaatc     1260

ccagcactta gggaggccga ggcgggagga tggcttgagg tccgtagttg agaccagcct     1320

ggccaacatg gtgaagcctg gtctctacaa aaaataataa caaaaattag ccgggtgtgg     1380

tggctcgtgc ctgtggtccc agctgctccg gtggctgagg cgggaggatc tcttgagctt     1440

aggcttttga gctatcatgg cgccagtgca ctccagcgtg ggcaacagag cgagaccctg     1500

tctctcaaaa aagaaaaaaa aaaaaaaaga aagagaaaag aaaagaaaga aagaagtgaa     1560

ggtttgtcag tcaggggagc tgtaaaacca ttaataaaga taatccaaga tggttaccaa     1620

gactgttgag gacgccagag atcttgagca ctttctaagt acctggcaat acactaagcg     1680

cgctcacctt ttcctctggc aaaacatgat cgaaagcaga atgttttgat catgagaaaa     1740

ttgcatttaa tttgaataca atttatttac aacataaagg ataatgtata tatcaccacc     1800

attactggta tttgctggtt atgttagatg tcattttaaa aaataacaat ctgatattta     1860

aaaaaaaatc ttattttgaa aatttccaaa gtaatacatg ccatgcatag accatttctg     1920

gaagatacca caagaaacat gtaatgatga ttgcctctga aggtctattt tcctcctctg     1980

acctgtgtgt gggttttgtt tttgttttac tgtgggcata aattaatttt tcagttaagt     2040

tttggaagct taaataactc tccaaaagtc ataaagccag taactggttg agcccaaatt     2100

caaacccagc ctgtctgata cttgtcctct tcttagaaaa gattacagtg atgctctcac     2160

aaaatcttgc cgccttccct caaacagaga gttccaggca ggatgaatct gtgctctgat     2220

ccctgaggca tttaatatgt tcttattatt agaagctcag atgcaaagag ctctcttagc     2280

ttttaatgtt atgaaaaaaa tcaggtcttc attagattcc ccaatccacc tcttgatggg     2340

gctagtagcc tttccttaat gatagggtgt ttctagagag atatatctgg tcaaggtggc     2400

ctggtactcc tccttctccc cacagcctcc cagacaagga ggagtagctg ccttttagtg     2460

atcatgtacc ctgaatataa gtgtatttaa aagaatttta tacacatata tttagtgtca     2520

atctgtatat ttagtagcac taacacttct cttcattttc aatgaaaaat atagagttta     2580

taatattttc ttcccacttc cccatggatg gtctagtcat gcctctcatt ttggaaagta     2640

ctgtttctga aacattaggc aatatattcc caacctggct agtttacagc aatcacctgt     2700

ggatgctaat taaaacgcaa atcccactgt cacatgcatt actccatttg atcataatgg     2760

aaagtatgtt ctgtcccatt tgccatagtc ctcacctatc cctgttgtat tttatcgggt     2820

ccaactcaac catttaaggt atttgccagc tcttgtatgc atttaggttt tgtttctttg     2880

ttttttagct catgaaatta ggtacaaagt cagagagggg tctggcatat aaaacctcag     2940

cagaaataaa gaggttttgt tgtttggtaa gaacatacct tgggttggtt gggcacggtg     3000

gctcgtgcct gtaatcccaa cactttggga ggccaaggca ggctgatcac ttgaagttgg     3060

gagttcaaga ccagcctggc caacatggtg aaatcccgtc tctactgaaa atacaaaaat     3120

taaccaggca tggtggtgtg tgcctgtagt cccaggaatc acttgaaccc aggaggcgga     3180

ggttgcagtg agctgagatc tcaccactgc acactgcact ccagcctggg caatggaatg     3240

agattccatc ccaaaaaata aaaaaataaa aaaataaaga acataccttg ggttgatcca     3300

cttaggaacc tcagataata acatctgcca cgtatagagc aattgctatg tcccaggcac     3360

tctactagac acttcataca gtttagaaaa tcagatgggt gtagatcaag gcaggagcag     3420

gaaccaaaaa gaaaggcata aacataagaa aaaaaatgga aggggtggaa acagagtaca     3480

ataacatgag taatttgatg ggggctatta tgaactgaga aatgaacttt gaaaagtatc     3540

ttggggccaa atcatgtaga ctcttgagtg atgtgttaag gaatgctatg agtgctgaga     3600

gggcatcaga agtccttgag agcctccaga gaaaggctct taaaaatgca gcgcaatctc     3660

cagtgacaga agatactgct agaaatctgc tagaaaaaaa acaaaaaagg catgtataga     3720

ggaattatga gggaaagata ccaagtcacg gtttattctt caaaatggag gtggcttgtt     3780

gggaaggtgg aagctcattt ggccagagtg gaaatggaat tgggagaaat cgatgaccaa     3840

atgtaaacac ttggtgcctg atatagcttg acaccaagtt agccccaagt gaaataccct     3900

ggcaatatta atgtgtcttt tcccgatatt cctcaggtac tccaaagatt caggtttact     3960

cacgtcatcc agcagagaat ggaaagtcaa atttcctgaa ttgctatgtg tctgggtttc     4020

atccatccga cattgaagtt gacttactga agaatggaga gagaattgaa aaagtggagc     4080

attcagactt gtctttcagc aaggactggt ctttctatct cttgtactac actgaattca     4140

cccccactga aaaagatgag tatgcctgcc gtgtgaacca tgtgactttg tcacagccca     4200

agatagttaa gtggggtaag tcttacattc ttttgtaagc tgctgaaagt tgtgtatgag     4260

tagtcatatc ataaagctgc tttgatataa aaaaggtcta tggccatact accctgaatg     4320

agtcccatcc catctgatat aaacaatctg catattggga ttgtcaggga atgttcttaa     4380

agatcagatt agtggcacct gctgagatac tgatgcacag catggtttct gaaccagtag     4440

tttccctgca gttgagcagg gagcagcagc agcacttgca caaatacata tacactctta     4500

acacttctta cctactggct tcctctagct tttgtggcag cttcaggtat atttagcact     4560

gaacgaacat ctcaagaagg tataggcctt tgtttgtaag tcctgctgtc ctagcatcct     4620

ataatcctgg acttctccag tactttctgg ctggattggt atctgaggct agtaggaagg     4680

gcttgttcct gctgggtagc tctaaacaat gtattcatgg gtaggaacag cagcctattc     4740

tgccagcctt atttctaacc attttagaca tttgttagta catggtattt taaaagtaaa     4800

acttaatgtc ttcctttttt ttctccactg tctttttcat agatcgagac atgtaagcag     4860

catcatggag gtaagttttt gaccttgaga aaatgttttt gtttcactgt cctgaggact     4920

atttatagac agctctaaca tgataaccct cactatgtgg agaacattga cagagtaaca     4980

ttttagcagg gaaagaagaa tcctacaggg tcatgttccc ttctcctgtg gagtggcatg     5040

aagaaggtgt atggccccag gtatggccat attactgacc ctctacagag agggcaaagg     5100

aactgccagt atggtattgc aggataaagg caggtggtta cccacattac ctgcaaggct     5160

ttgatctttc ttctgccatt tccacattgg acatctctgc tgaggagaga aaatgaacca     5220

ctcttttcct ttgtataatg ttgttttatt cttcagacag aagagaggag ttatacagct     5280

ctgcagacat cccattcctg tatggggact gtgtttgcct cttagaggtt cccaggccac     5340

tagaggagat aaagggaaac agattgttat aacttgatat aatgatacta taatagatgt     5400

aactacaagg agctccagaa gcaagagaga gggaggaact tggacttctc tgcatcttta     5460

gttggagtcc aaaggctttt caatgaaatt ctactgccca gggtacattg atgctgaaac     5520

cccattcaaa tctcctgtta tattctagaa cagggaattg atttgggaga gcatcaggaa     5580

ggtggatgat ctgcccagtc acactgttag taaattgtag agccaggacc tgaactctaa     5640

tatagtcatg tgttacttaa tgacggggac atgttctgag aaatgcttac acaaacctag     5700

gtgttgtagc ctactacacg cataggctac atggtatagc ctattgctcc tagactacaa     5760

acctgtacag cctgttactg tactgaatac tgtgggcagt tgtaacacaa tggtaagtat     5820

ttgtgtatct aaacatagaa gttgcagtaa aaatatgcta ttttaatctt atgagaccac     5880

tgtcatatat acagtccatc attgaccaaa acatcatatc agcatttttt cttctaagat     5940

tttgggagca ccaaagggat acactaacag gatatactct ttataatggg tttggagaac     6000

tgtctgcagc tacttctttt aaaaaggtga tctacacagt agaaattaga caagtttggt     6060

aatgagatct gcaatccaaa taaaataaat tcattgctaa cctttttctt ttcttttcag     6120

gtttgaagat gccgcatttg gattggatga attccaaatt ctgcttgctt gctttttaat     6180

attgatatgc ttatacactt acactttatg cacaaaatgt agggttataa taatgttaac     6240

atggacatga tcttctttat aattctactt tgagtgctgt ctccatgttt gatgtatctg     6300

agcaggttgc tccacaggta gctctaggag ggctggcaac ttagaggtgg ggagcagaga     6360

attctcttat ccaacatcaa catcttggtc agatttgaac tcttcaatct cttgcactca     6420

aagcttgtta agatagttaa gcgtgcataa gttaacttcc aatttacata ctctgcttag     6480

aatttggggg aaaatttaga aatataattg acaggattat tggaaatttg ttataatgaa     6540

tgaaacattt tgtcatataa gattcatatt tacttcttat acatttgata aagtaaggca     6600

tggttgtggt taatctggtt tatttttgtt ccacaagtta aataaatcat aaaacttgat     6660

gtgttatctc tta                                                        6673


<210>  3
<211>  987
<212>  DNA
<213>  Homo sapiens

<400>  3
aatataagtg gaggcgtcgc gctggcgggc attcctgaag ctgacagcat tcgggccgag       60

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggct      120

atccagcgta ctccaaagat tcaggtttac tcacgtcatc cagcagagaa tggaaagtca      180

aatttcctga attgctatgt gtctgggttt catccatccg acattgaagt tgacttactg      240

aagaatggag agagaattga aaaagtggag cattcagact tgtctttcag caaggactgg      300

tctttctatc tcttgtacta cactgaattc acccccactg aaaaagatga gtatgcctgc      360

cgtgtgaacc atgtgacttt gtcacagccc aagatagtta agtgggatcg agacatgtaa      420

gcagcatcat ggaggtttga agatgccgca tttggattgg atgaattcca aattctgctt      480

gcttgctttt taatattgat atgcttatac acttacactt tatgcacaaa atgtagggtt      540

ataataatgt taacatggac atgatcttct ttataattct actttgagtg ctgtctccat      600

gtttgatgta tctgagcagg ttgctccaca ggtagctcta ggagggctgg caacttagag      660

gtggggagca gagaattctc ttatccaaca tcaacatctt ggtcagattt gaactcttca      720

atctcttgca ctcaaagctt gttaagatag ttaagcgtgc ataagttaac ttccaattta      780

catactctgc ttagaatttg ggggaaaatt tagaaatata attgacagga ttattggaaa      840

tttgttataa tgaatgaaac attttgtcat ataagattca tatttacttc ttatacattt      900

gataaagtaa ggcatggttg tggttaatct ggtttatttt tgttccacaa gttaaataaa      960

tcataaaact tgatgtgtta tctctta                                          987


<210>  4
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Thr Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Thr Asp Thr Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Thr Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Lys His Ile Gly Pro Asp Glu Val Ile 
        115                 120                 125             


Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln Lys 
    130                 135                 140                 


Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys Pro 
145                 150                 155                 160 


Ala Glu Pro Pro Thr Val Val Thr Gly Ser Leu Leu Val Gly Pro Val 
                165                 170                 175     


Ser Asp Cys Ser Thr Leu Pro Cys Leu Pro Leu Pro Ala Leu Phe Asn 
            180                 185                 190         


Gln Glu Pro Ala Ser Gly Gln Met Arg Leu Glu Lys Thr Asp Gln Ile 
        195                 200                 205             


Pro Met Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro Glu 
    210                 215                 220                 


Gly Pro Ile Gln Phe Val Pro Thr Ile Ser Thr Leu Pro His Gly Leu 
225                 230                 235                 240 


Trp Gln Ile Ser Glu Ala Gly Thr Gly Val Ser Ser Ile Phe Ile Tyr 
                245                 250                 255     


His Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly Phe 
            260                 265                 270         


Thr Val His Gly Leu Pro Thr Ser Pro Asp Arg Pro Gly Ser Thr Ser 
        275                 280                 285             


Pro Phe Ala Pro Ser Ala Thr Asp Leu Pro Ser Met Pro Glu Pro Ala 
    290                 295                 300                 


Leu Thr Ser Arg Ala Asn Met Thr Glu His Lys Thr Ser Pro Thr Gln 
305                 310                 315                 320 


Cys Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro Glu 
                325                 330                 335     


Pro Val Glu Gln Phe Tyr Arg Ser Leu Gln Asp Thr Tyr Gly Ala Glu 
            340                 345                 350         


Pro Ala Gly Pro Asp Gly Ile Leu Val Glu Val Asp Leu Val Gln Ala 
        355                 360                 365             


Arg Leu Glu Arg Ser Ser Ser Lys Ser Leu Glu Arg Glu Leu Ala Thr 
    370                 375                 380                 


Pro Asp Trp Ala Glu Arg Gln Leu Ala Gln Gly Gly Leu Ala Glu Val 
385                 390                 395                 400 


Leu Leu Ala Ala Lys Glu His Arg Arg Pro Arg Glu Thr Arg Val Ile 
                405                 410                 415     


Ala Val Leu Gly Lys Ala Gly Gln Gly Lys Ser Tyr Trp Ala Gly Ala 
            420                 425                 430         


Val Ser Arg Ala Trp Ala Cys Gly Arg Leu Pro Gln Tyr Asp Phe Val 
        435                 440                 445             


Phe Ser Val Pro Cys His Cys Leu Asn Arg Pro Gly Asp Ala Tyr Gly 
    450                 455                 460                 


Leu Gln Asp Leu Leu Phe Ser Leu Gly Pro Gln Pro Leu Val Ala Ala 
465                 470                 475                 480 


Asp Glu Val Phe Ser His Ile Leu Lys Arg Pro Asp Arg Val Leu Leu 
                485                 490                 495     


Ile Leu Asp Gly Phe Glu Glu Leu Glu Ala Gln Asp Gly Phe Leu His 
            500                 505                 510         


Ser Thr Cys Gly Pro Ala Pro Ala Glu Pro Cys Ser Leu Arg Gly Leu 
        515                 520                 525             


Leu Ala Gly Leu Phe Gln Lys Lys Leu Leu Arg Gly Cys Thr Leu Leu 
    530                 535                 540                 


Leu Thr Ala Arg Pro Arg Gly Arg Leu Val Gln Ser Leu Ser Lys Ala 
545                 550                 555                 560 


Asp Ala Leu Phe Glu Leu Ser Gly Phe Ser Met Glu Gln Ala Gln Ala 
                565                 570                 575     


Tyr Val Met Arg Tyr Phe Glu Ser Ser Gly Met Thr Glu His Gln Asp 
            580                 585                 590         


Arg Ala Leu Thr Leu Leu Arg Asp Arg Pro Leu Leu Leu Ser His Ser 
        595                 600                 605             


His Ser Pro Thr Leu Cys Arg Ala Val Cys Gln Leu Ser Glu Ala Leu 
    610                 615                 620                 


Leu Glu Leu Gly Glu Asp Ala Lys Leu Pro Ser Thr Leu Thr Gly Leu 
625                 630                 635                 640 


Tyr Val Gly Leu Leu Gly Arg Ala Ala Leu Asp Ser Pro Pro Gly Ala 
                645                 650                 655     


Leu Ala Glu Leu Ala Lys Leu Ala Trp Glu Leu Gly Arg Arg His Gln 
            660                 665                 670         


Ser Thr Leu Gln Glu Asp Gln Phe Pro Ser Ala Asp Val Arg Thr Trp 
        675                 680                 685             


Ala Met Ala Lys Gly Leu Val Gln His Pro Pro Arg Ala Ala Glu Ser 
    690                 695                 700                 


Glu Leu Ala Phe Pro Ser Phe Leu Leu Gln Cys Phe Leu Gly Ala Leu 
705                 710                 715                 720 


Trp Leu Ala Leu Ser Gly Glu Ile Lys Asp Lys Glu Leu Pro Gln Tyr 
                725                 730                 735     


Leu Ala Leu Thr Pro Arg Lys Lys Arg Pro Tyr Asp Asn Trp Leu Glu 
            740                 745                 750         


Gly Val Pro Arg Phe Leu Ala Gly Leu Ile Phe Gln Pro Pro Ala Arg 
        755                 760                 765             


Cys Leu Gly Ala Leu Leu Gly Pro Ser Ala Ala Ala Ser Val Asp Arg 
    770                 775                 780                 


Lys Gln Lys Val Leu Ala Arg Tyr Leu Lys Arg Leu Gln Pro Gly Thr 
785                 790                 795                 800 


Leu Arg Ala Arg Gln Leu Leu Glu Leu Leu His Cys Ala His Glu Ala 
                805                 810                 815     


Glu Glu Ala Gly Ile Trp Gln His Val Val Gln Glu Leu Pro Gly Arg 
            820                 825                 830         


Leu Ser Phe Leu Gly Thr Arg Leu Thr Pro Pro Asp Ala His Val Leu 
        835                 840                 845             


Gly Lys Ala Leu Glu Ala Ala Gly Gln Asp Phe Ser Leu Asp Leu Arg 
    850                 855                 860                 


Ser Thr Gly Ile Cys Pro Ser Gly Leu Gly Ser Leu Val Gly Leu Ser 
865                 870                 875                 880 


Cys Val Thr Arg Phe Arg Ala Ala Leu Ser Asp Thr Val Ala Leu Trp 
                885                 890                 895     


Glu Ser Leu Gln Gln His Gly Glu Thr Lys Leu Leu Gln Ala Ala Glu 
            900                 905                 910         


Glu Lys Phe Thr Ile Glu Pro Phe Lys Ala Lys Ser Leu Lys Asp Val 
        915                 920                 925             


Glu Asp Leu Gly Lys Leu Val Gln Thr Gln Arg Thr Arg Ser Ser Ser 
    930                 935                 940                 


Glu Asp Thr Ala Gly Glu Leu Pro Ala Val Arg Asp Leu Lys Lys Leu 
945                 950                 955                 960 


Glu Phe Ala Leu Gly Pro Val Ser Gly Pro Gln Ala Phe Pro Lys Leu 
                965                 970                 975     


Val Arg Ile Leu Thr Ala Phe Ser Ser Leu Gln His Leu Asp Leu Asp 
            980                 985                 990         


Ala Leu Ser Glu Asn Lys Ile Gly  Asp Glu Gly Val Ser  Gln Leu Ser 
        995                 1000                 1005             


Ala Thr  Phe Pro Gln Leu Lys  Ser Leu Glu Thr Leu  Asn Leu Ser 
    1010                 1015                 1020             


Gln Asn  Asn Ile Thr Asp Leu  Gly Ala Tyr Lys Leu  Ala Glu Ala 
    1025                 1030                 1035             


Leu Pro  Ser Leu Ala Ala Ser  Leu Leu Arg Leu Ser  Leu Tyr Asn 
    1040                 1045                 1050             


Asn Cys  Ile Cys Asp Val Gly  Ala Glu Ser Leu Ala  Arg Val Leu 
    1055                 1060                 1065             


Pro Asp  Met Val Ser Leu Arg  Val Met Asp Val Gln  Tyr Asn Lys 
    1070                 1075                 1080             


Phe Thr  Ala Ala Gly Ala Gln  Gln Leu Ala Ala Ser  Leu Arg Arg 
    1085                 1090                 1095             


Cys Pro  His Val Glu Thr Leu  Ala Met Trp Thr Pro  Thr Ile Pro 
    1100                 1105                 1110             


Phe Ser  Val Gln Glu His Leu  Gln Gln Gln Asp Ser  Arg Ile Ser 
    1115                 1120                 1125             


Leu Arg  
    1130 


<210>  5
<211>  4654
<212>  DNA
<213>  Homo sapiens

<400>  5
ggttagtgat gaggctagtg atgaggctgt gtgcttctga gctgggcatc cgaaggcatc       60

cttggggaag ctgagggcac gaggaggggc tgccagactc cgggagctgc tgcctggctg      120

ggattcctac acaatgcgtt gcctggctcc acgccctgct gggtcctacc tgtcagagcc      180

ccaaggcagc tcacagtgtg ccaccatgga gttggggccc ctagaaggtg gctacctgga      240

gcttcttaac agcgatgctg accccctgtg cctctaccac ttctatgacc agatggacct      300

ggctggagaa gaagagattg agctctactc agaacccgac acagacacca tcaactgcga      360

ccagttcagc aggctgttgt gtgacatgga aggtgatgaa gagaccaggg aggcttatgc      420

caatatcgcg gaactggacc agtatgtctt ccaggactcc cagctggagg gcctgagcaa      480

ggacattttc aagcacatag gaccagatga agtgatcggt gagagtatgg agatgccagc      540

agaagttggg cagaaaagtc agaaaagacc cttcccagag gagcttccgg cagacctgaa      600

gcactggaag ccagctgagc cccccactgt ggtgactggc agtctcctag tgggaccagt      660

gagcgactgc tccaccctgc cctgcctgcc actgcctgcg ctgttcaacc aggagccagc      720

ctccggccag atgcgcctgg agaaaaccga ccagattccc atgcctttct ccagttcctc      780

gttgagctgc ctgaatctcc ctgagggacc catccagttt gtccccacca tctccactct      840

gccccatggg ctctggcaaa tctctgaggc tggaacaggg gtctccagta tattcatcta      900

ccatggtgag gtgccccagg ccagccaagt accccctccc agtggattca ctgtccacgg      960

cctcccaaca tctccagacc ggccaggctc caccagcccc ttcgctccat cagccactga     1020

cctgcccagc atgcctgaac ctgccctgac ctcccgagca aacatgacag agcacaagac     1080

gtcccccacc caatgcccgg cagctggaga ggtctccaac aagcttccaa aatggcctga     1140

gccggtggag cagttctacc gctcactgca ggacacgtat ggtgccgagc ccgcaggccc     1200

ggatggcatc ctagtggagg tggatctggt gcaggccagg ctggagagga gcagcagcaa     1260

gagcctggag cgggaactgg ccaccccgga ctgggcagaa cggcagctgg cccaaggagg     1320

cctggctgag gtgctgttgg ctgccaagga gcaccggcgg ccgcgtgaga cacgagtgat     1380

tgctgtgctg ggcaaagctg gtcagggcaa gagctattgg gctggggcag tgagccgggc     1440

ctgggcttgt ggccggcttc cccagtacga ctttgtcttc tctgtcccct gccattgctt     1500

gaaccgtccg ggggatgcct atggcctgca ggatctgctc ttctccctgg gcccacagcc     1560

actcgtggcg gccgatgagg ttttcagcca catcttgaag agacctgacc gcgttctgct     1620

catcctagac ggcttcgagg agctggaagc gcaagatggc ttcctgcaca gcacgtgcgg     1680

accggcaccg gcggagccct gctccctccg ggggctgctg gccggccttt tccagaagaa     1740

gctgctccga ggttgcaccc tcctcctcac agcccggccc cggggccgcc tggtccagag     1800

cctgagcaag gccgacgccc tatttgagct gtccggcttc tccatggagc aggcccaggc     1860

atacgtgatg cgctactttg agagctcagg gatgacagag caccaagaca gagccctgac     1920

gctcctccgg gaccggccac ttcttctcag tcacagccac agccctactt tgtgccgggc     1980

agtgtgccag ctctcagagg ccctgctgga gcttggggag gacgccaagc tgccctccac     2040

gctcacggga ctctatgtcg gcctgctggg ccgtgcagcc ctcgacagcc cccccggggc     2100

cctggcagag ctggccaagc tggcctggga gctgggccgc agacatcaaa gtaccctaca     2160

ggaggaccag ttcccatccg cagacgtgag gacctgggcg atggccaaag gcttagtcca     2220

acacccaccg cgggccgcag agtccgagct ggccttcccc agcttcctcc tgcaatgctt     2280

cctgggggcc ctgtggctgg ctctgagtgg cgaaatcaag gacaaggagc tcccgcagta     2340

cctagcattg accccaagga agaagaggcc ctatgacaac tggctggagg gcgtgccacg     2400

ctttctggct gggctgatct tccagcctcc cgcccgctgc ctgggagccc tactcgggcc     2460

atcggcggct gcctcggtgg acaggaagca gaaggtgctt gcgaggtacc tgaagcggct     2520

gcagccgggg acactgcggg cgcggcagct gctggagctg ctgcactgcg cccacgaggc     2580

cgaggaggct ggaatttggc agcacgtggt acaggagctc cccggccgcc tctcttttct     2640

gggcacccgc ctcacgcctc ctgatgcaca tgtactgggc aaggccttgg aggcggcggg     2700

ccaagacttc tccctggacc tccgcagcac tggcatttgc ccctctggat tggggagcct     2760

cgtgggactc agctgtgtca cccgtttcag ggctgccttg agcgacacgg tggcgctgtg     2820

ggagtccctg cagcagcatg gggagaccaa gctacttcag gcagcagagg agaagttcac     2880

catcgagcct ttcaaagcca agtccctgaa ggatgtggaa gacctgggaa agcttgtgca     2940

gactcagagg acgagaagtt cctcggaaga cacagctggg gagctccctg ctgttcggga     3000

cctaaagaaa ctggagtttg cgctgggccc tgtctcaggc ccccaggctt tccccaaact     3060

ggtgcggatc ctcacggcct tttcctccct gcagcatctg gacctggatg cgctgagtga     3120

gaacaagatc ggggacgagg gtgtctcgca gctctcagcc accttccccc agctgaagtc     3180

cttggaaacc ctcaatctgt cccagaacaa catcactgac ctgggtgcct acaaactcgc     3240

cgaggccctg ccttcgctcg ctgcatccct gctcaggcta agcttgtaca ataactgcat     3300

ctgcgacgtg ggagccgaga gcttggctcg tgtgcttccg gacatggtgt ccctccgggt     3360

gatggacgtc cagtacaaca agttcacggc tgccggggcc cagcagctcg ctgccagcct     3420

tcggaggtgt cctcatgtgg agacgctggc gatgtggacg cccaccatcc cattcagtgt     3480

ccaggaacac ctgcaacaac aggattcacg gatcagcctg agatgatccc agctgtgctc     3540

tggacaggca tgttctctga ggacactaac cacgctggac cttgaactgg gtacttgtgg     3600

acacagctct tctccaggct gtatcccatg agcctcagca tcctggcacc cggcccctgc     3660

tggttcaggg ttggcccctg cccggctgcg gaatgaacca catcttgctc tgctgacaga     3720

cacaggcccg gctccaggct cctttagcgc ccagttgggt ggatgcctgg tggcagctgc     3780

ggtccaccca ggagccccga ggccttctct gaaggacatt gcggacagcc acggccaggc     3840

cagagggagt gacagaggca gccccattct gcctgcccag gcccctgcca ccctggggag     3900

aaagtacttc ttttttttta tttttagaca gagtctcact gttgcccagg ctggcgtgca     3960

gtggtgcgat ctgggttcac tgcaacctcc gcctcttggg ttcaagcgat tcttctgctt     4020

cagcctcccg agtagctggg actacaggca cccaccatca tgtctggcta atttttcatt     4080

tttagtagag acagggtttt gccatgttgg ccaggctggt ctcaaactct tgacctcagg     4140

tgatccaccc acctcagcct cccaaagtgc tgggattaca agcgtgagcc actgcaccgg     4200

gccacagaga aagtacttct ccaccctgct ctccgaccag acaccttgac agggcacacc     4260

gggcactcag aagacactga tgggcaaccc ccagcctgct aattccccag attgcaacag     4320

gctgggcttc agtggcagct gcttttgtct atgggactca atgcactgac attgttggcc     4380

aaagccaaag ctaggcctgg ccagatgcac cagcccttag cagggaaaca gctaatggga     4440

cactaatggg gcggtgagag gggaacagac tggaagcaca gcttcatttc ctgtgtcttt     4500

tttcactaca ttataaatgt ctctttaatg tcacaggcag gtccagggtt tgagttcata     4560

ccctgttacc attttggggt acccactgct ctggttatct aatatgtaac aagccacccc     4620

aaatcatagt ggcttaaaac aacactcaca ttta                                 4654


<210>  6
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 Cimeric Antigen Receptor

<400>  6

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr 
65                  70                  75                  80  


Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
145                 150                 155                 160 


Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser 
                165                 170                 175     


Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr 
            180                 185                 190         


Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu 
        195                 200                 205             


Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu 
225                 230                 235                 240 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro 
                245                 250                 255     


Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANti-CD19 CAR

<400>  7

Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala 
    


<210>  8
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  8
gagaatcaaa atcggtgaat agg                                               23


<210>  9
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  9
ttcaaaacct gtcagtgatt ggg                                               23


<210>  10
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  10
tgtgctagac atgaggtcta tgg                                               23


<210>  11
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  11
cgtcatgagc agattaaacc cgg                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  12
tcagggttct ggatatctgt ggg                                               23


<210>  13
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  13
gtcagggttc tggatatctg tgg                                               23


<210>  14
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  14
ttcggaaccc aatcactgac agg                                               23


<210>  15
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  15
taaacccggc cactttcagg agg                                               23


<210>  16
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  16
aaagtcagat ttgttgctcc agg                                               23


<210>  17
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  17
aacaaatgtg tcacaaagta agg                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  18
tggatttaga gtctctcagc tgg                                               23


<210>  19
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  19
taggcagaca gacttgtcac tgg                                               23


<210>  20
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  20
agctggtaca cggcagggtc agg                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  21
gctggtacac ggcagggtca ggg                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  22
tctctcagct ggtacacggc agg                                               23


<210>  23
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  23
tttcaaaacc tgtcagtgat tgg                                               23


<210>  24
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  24
gattaaaccc ggccactttc agg                                               23


<210>  25
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  25
ctcgaccagc ttgacatcac agg                                               23


<210>  26
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  26
agagtctctc agctggtaca cgg                                               23


<210>  27
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  27
ctctcagctg gtacacggca ggg                                               23


<210>  28
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  28
aagttcctgt gatgtcaagc tgg                                               23


<210>  29
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  29
atcctcctcc tgaaagtggc cgg                                               23


<210>  30
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  30
tgctcatgac gctgcggctg tgg                                               23


<210>  31
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  31
acaaaactgt gctagacatg agg                                               23


<210>  32
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  32
atttgtttga gaatcaaaat cgg                                               23


<210>  33
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  33
catcacagga actttctaaa agg                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  34
gtcgagaaaa gctttgaaac agg                                               23


<210>  35
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  35
ccactttcag gaggaggatt cgg                                               23


<210>  36
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  36
ctgacaggtt ttgaaagttt agg                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  37
agctttgaaa caggtaagac agg                                               23


<210>  38
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  38
tggaataatg ctgttgttga agg                                               23


<210>  39
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  39
agagcaacag tgctgtggcc tgg                                               23


<210>  40
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  40
ctgtggtcca gctgaggtga ggg                                               23


<210>  41
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  41
ctgcggctgt ggtccagctg agg                                               23


<210>  42
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  42
tgtggtccag ctgaggtgag ggg                                               23


<210>  43
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  43
cttcttcccc agcccaggta agg                                               23


<210>  44
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  44
acacggcagg gtcagggttc tgg                                               23


<210>  45
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  45
cttcaagagc aacagtgctg tgg                                               23


<210>  46
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  46
ctggggaaga aggtgtcttc tgg                                               23


<210>  47
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  47
tcctcctcct gaaagtggcc ggg                                               23


<210>  48
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  48
ttaatctgct catgacgctg cgg                                               23


<210>  49
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  49
acccggccac tttcaggagg agg                                               23


<210>  50
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  50
ttcttcccca gcccaggtaa ggg                                               23


<210>  51
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  51
cttacctggg ctggggaaga agg                                               23


<210>  52
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  52
gacaccttct tccccagccc agg                                               23


<210>  53
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  53
gctgtggtcc agctgaggtg agg                                               23


<210>  54
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  54
ccgaatcctc ctcctgaaag tgg                                               23


<210>  55
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  55
ttccctccca ggcagctcac agtgtgccac catggagttg gggccccta                   49


<210>  56
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  56
tgcctctacc acttctatga ccagatggac ctggctggag aagaagaga                   49


<210>  57
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  57
tcttcatcca agggactttt cctcccagaa cccgacacag acaccatca                   49


<210>  58
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  58
tgttgtgtga catggaaggt gatgaagaga ccagggaggc ttatgccaa                   49


<210>  59
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  59
ccaaagattc aggtttactc acgtcatcca gcagagaatg gaaagtc                     47


<210>  60
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  60
ttgtcccaca gatatccaga accctgaccc tgccgtgtac cagctgaga                   49


<210>  61
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  61
tgtgtttgag ccatcagaag cagagatctc ccacacccaa aaggccaca                   49


<210>  62
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  62
ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca                  50


<210>  63
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  63
tttagaaagt tcctgtgatg tcaagctggt cgagaaaagc tttgaaaca                   49


<210>  64
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  64
tccagtgaca agtctgtctg cctattcacc gattttgatt ctcaaacaa                   49


<210>  65
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  65
tatatcacag acaaaactgt gctagacatg aggtctatgg acttcaaga                   49


<210>  66
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  66
tgaggtctat ggacttcaag agcaacagtg ctgtggcctg gagcaacaa                   49


<210>  67
<211>  2814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE-nuclease sequence

<400>  67
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac       60

gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc      120

aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt      180

acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc      240

aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc      300

ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg      360

agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc      420

gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac      480

ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag      540

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg      600

gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg      660

ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagcaat      720

attggtggca agcaggcgct ggagacggtg caggcgctgt tgccggtgct gtgccaggcc      780

cacggcttga ccccggagca ggtggtggcc atcgccagca atattggtgg caagcaggcg      840

ctggagacgg tgcaggcgct gttgccggtg ctgtgccagg cccacggctt gaccccggag      900

caggtggtgg ccatcgccag caatattggt ggcaagcagg cgctggagac ggtgcaggcg      960

ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc     1020

agcaataatg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc     1080

caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagcaatat tggtggcaag     1140

caggcgctgg agacggtgca ggcgctgttg ccggtgctgt gccaggccca cggcttgacc     1200

ccccagcagg tggtggccat cgccagcaat ggcggtggca agcaggcgct ggagacggtc     1260

cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc     1320

atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg     1380

ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag ccacgatggc     1440

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc     1500

ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca ggcgctggag     1560

acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg     1620

gtggccatcg ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg     1680

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat     1740

aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc     1800

cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg     1860

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccccag     1920

caggtggtgg ccatcgccag caatggcggt ggcaagcagg cgctggagac ggtccagcgg     1980

ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc     2040

agcaatggcg gcggcaggcc ggcgctggag agcattgttg cccagttatc tcgccctgat     2100

ccggcgttgg ccgcgttgac caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt     2160

cctgcgctgg atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg     2220

aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac     2280

gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat cctggagatg     2340

aaggtgatgg agttcttcat gaaggtgtac ggctacaggg gcaagcacct gggcggctcc     2400

aggaagcccg acggcgccat ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg     2460

gacaccaagg cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag     2520

aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag     2580

gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca cttcaagggc     2640

aactacaagg cccagctgac caggctgaac cacatcacca actgcaacgg cgccgtgctg     2700

tccgtggagg agctcctgat cggcggcgag atgatcaagg ccggcaccct gaccctggag     2760

gaggtgagga ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa           2814


<210>  68
<211>  2832
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE-nuclease sequence

<400>  68
atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc       60

gagagacagc acatggacag catcgatatc gccgatctac gcacgctcgg ctacagccag      120

cagcaacagg agaagatcaa accgaaggtt cgttcgacag tggcgcagca ccacgaggca      180

ctggtcggcc acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg      240

ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga ggcgacacac      300

gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac gcgctctgga ggccttgctc      360

acggtggcgg gagagttgag aggtccaccg ttacagttgg acacaggcca acttctcaag      420

attgcaaaac gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg caatgcactg      480

acgggtgccc cgctcaactt gaccccccag caggtggtgg ccatcgccag caataatggt      540

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc      600

ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca ggcgctggag      660

acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg      720

gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg      780

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat      840

ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc      900

cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg      960

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccccag     1020

caggtggtgg ccatcgccag caatggcggt ggcaagcagg cgctggagac ggtccagcgg     1080

ctgttgccgg tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc     1140

agccacgatg gcggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc     1200

caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagccacga tggcggcaag     1260

caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc     1320

ccggagcagg tggtggccat cgccagcaat attggtggca agcaggcgct ggagacggtg     1380

caggcgctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc     1440

atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg     1500

ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag caatggcggt     1560

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc     1620

ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag     1680

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg     1740

gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca gcggctgttg     1800

ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac     1860

gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc     1920

cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg     1980

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gacccctcag     2040

caggtggtgg ccatcgccag caatggcggc ggcaggccgg cgctggagag cattgttgcc     2100

cagttatctc gccctgatcc ggcgttggcc gcgttgacca acgaccacct cgtcgccttg     2160

gcctgcctcg gcgggcgtcc tgcgctggat gcagtgaaaa agggattggg ggatcctatc     2220

agccgttccc agctggtgaa gtccgagctg gaggagaaga aatccgagtt gaggcacaag     2280

ctgaagtacg tgccccacga gtacatcgag ctgatcgaga tcgcccggaa cagcacccag     2340

gaccgtatcc tggagatgaa ggtgatggag ttcttcatga aggtgtacgg ctacaggggc     2400

aagcacctgg gcggctccag gaagcccgac ggcgccatct acaccgtggg ctcccccatc     2460

gactacggcg tgatcgtgga caccaaggcc tactccggcg gctacaacct gcccatcggc     2520

caggccgacg aaatgcagag gtacgtggag gagaaccaga ccaggaacaa gcacatcaac     2580

cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg     2640

tccggccact tcaagggcaa ctacaaggcc cagctgacca ggctgaacca catcaccaac     2700

tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg gcggcgagat gatcaaggcc     2760

ggcaccctga ccctggagga ggtgaggagg aagttcaaca acggcgagat caacttcgcg     2820

gccgactgat aa                                                         2832


<210>  69
<211>  2814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE-nuclease sequence

<400>  69
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac       60

gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc      120

aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt      180

acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc      240

aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc      300

ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg      360

agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc      420

gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac      480

ttgacccccc agcaggtggt ggccatcgcc agcaatggcg gtggcaagca ggcgctggag      540

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg      600

gtggccatcg ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg      660

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat      720

ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc      780

cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg caagcaggcg      840

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag      900

caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg      960

ctgttgccgg tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc     1020

agccacgatg gcggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc     1080

caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagcaatat tggtggcaag     1140

caggcgctgg agacggtgca ggcgctgttg ccggtgctgt gccaggccca cggcttgacc     1200

ccggagcagg tggtggccat cgccagccac gatggcggca agcaggcgct ggagacggtc     1260

cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc     1320

atcgccagca atattggtgg caagcaggcg ctggagacgg tgcaggcgct gttgccggtg     1380

ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag caataatggt     1440

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc     1500

ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca ggcgctggag     1560

acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg     1620

gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca gcggctgttg     1680

ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagcaat     1740

attggtggca agcaggcgct ggagacggtg caggcgctgt tgccggtgct gtgccaggcc     1800

cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg     1860

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag     1920

caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg     1980

ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc     2040

agcaatggcg gcggcaggcc ggcgctggag agcattgttg cccagttatc tcgccctgat     2100

ccggcgttgg ccgcgttgac caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt     2160

cctgcgctgg atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg     2220

aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac     2280

gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat cctggagatg     2340

aaggtgatgg agttcttcat gaaggtgtac ggctacaggg gcaagcacct gggcggctcc     2400

aggaagcccg acggcgccat ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg     2460

gacaccaagg cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag     2520

aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag     2580

gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca cttcaagggc     2640

aactacaagg cccagctgac caggctgaac cacatcacca actgcaacgg cgccgtgctg     2700

tccgtggagg agctcctgat cggcggcgag atgatcaagg ccggcaccct gaccctggag     2760

gaggtgagga ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa           2814


<210>  70
<211>  2832
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE-nuclease sequence

<400>  70
atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc       60

gagagacagc acatggacag catcgatatc gccgatctac gcacgctcgg ctacagccag      120

cagcaacagg agaagatcaa accgaaggtt cgttcgacag tggcgcagca ccacgaggca      180

ctggtcggcc acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg      240

ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga ggcgacacac      300

gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac gcgctctgga ggccttgctc      360

acggtggcgg gagagttgag aggtccaccg ttacagttgg acacaggcca acttctcaag      420

attgcaaaac gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg caatgcactg      480

acgggtgccc cgctcaactt gaccccggag caggtggtgg ccatcgccag ccacgatggc      540

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc      600

ttgacccccc agcaggtggt ggccatcgcc agcaatggcg gtggcaagca ggcgctggag      660

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg      720

gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg      780

ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagcaat      840

attggtggca agcaggcgct ggagacggtg caggcgctgt tgccggtgct gtgccaggcc      900

cacggcttga ccccccagca ggtggtggcc atcgccagca ataatggtgg caagcaggcg      960

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag     1020

caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg     1080

ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc     1140

agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc     1200

caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaataa tggtggcaag     1260

caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc     1320

ccccagcagg tggtggccat cgccagcaat aatggtggca agcaggcgct ggagacggtc     1380

cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc     1440

atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg     1500

ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag caatattggt     1560

ggcaagcagg cgctggagac ggtgcaggcg ctgttgccgg tgctgtgcca ggcccacggc     1620

ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag     1680

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg     1740

gtggccatcg ccagcaatat tggtggcaag caggcgctgg agacggtgca ggcgctgttg     1800

ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac     1860

gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc     1920

cacggcttga ccccccagca ggtggtggcc atcgccagca ataatggtgg caagcaggcg     1980

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gacccctcag     2040

caggtggtgg ccatcgccag caatggcggc ggcaggccgg cgctggagag cattgttgcc     2100

cagttatctc gccctgatcc ggcgttggcc gcgttgacca acgaccacct cgtcgccttg     2160

gcctgcctcg gcgggcgtcc tgcgctggat gcagtgaaaa agggattggg ggatcctatc     2220

agccgttccc agctggtgaa gtccgagctg gaggagaaga aatccgagtt gaggcacaag     2280

ctgaagtacg tgccccacga gtacatcgag ctgatcgaga tcgcccggaa cagcacccag     2340

gaccgtatcc tggagatgaa ggtgatggag ttcttcatga aggtgtacgg ctacaggggc     2400

aagcacctgg gcggctccag gaagcccgac ggcgccatct acaccgtggg ctcccccatc     2460

gactacggcg tgatcgtgga caccaaggcc tactccggcg gctacaacct gcccatcggc     2520

caggccgacg aaatgcagag gtacgtggag gagaaccaga ccaggaacaa gcacatcaac     2580

cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg     2640

tccggccact tcaagggcaa ctacaaggcc cagctgacca ggctgaacca catcaccaac     2700

tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg gcggcgagat gatcaaggcc     2760

ggcaccctga ccctggagga ggtgaggagg aagttcaaca acggcgagat caacttcgcg     2820

gccgactgat aa                                                         2832


<210>  71
<211>  2814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE-nuclease sequence

<400>  71
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac       60

gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc      120

aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt      180

acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc      240

aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc      300

ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg      360

agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc      420

gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac      480

ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag      540

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg      600

gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca gcggctgttg      660

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat      720

aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc      780

cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg      840

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccccag      900

caggtggtgg ccatcgccag caatggcggt ggcaagcagg cgctggagac ggtccagcgg      960

ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc     1020

agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc     1080

caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaataa tggtggcaag     1140

caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc     1200

ccggagcagg tggtggccat cgccagcaat attggtggca agcaggcgct ggagacggtg     1260

caggcgctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc     1320

atcgccagca ataatggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg     1380

ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag ccacgatggc     1440

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc     1500

ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag     1560

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg     1620

gtggccatcg ccagcaatat tggtggcaag caggcgctgg agacggtgca ggcgctgttg     1680

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat     1740

ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc     1800

cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg caagcaggcg     1860

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag     1920

caggtggtgg ccatcgccag caatattggt ggcaagcagg cgctggagac ggtgcaggcg     1980

ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc     2040

agcaatggcg gcggcaggcc ggcgctggag agcattgttg cccagttatc tcgccctgat     2100

ccggcgttgg ccgcgttgac caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt     2160

cctgcgctgg atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg     2220

aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac     2280

gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat cctggagatg     2340

aaggtgatgg agttcttcat gaaggtgtac ggctacaggg gcaagcacct gggcggctcc     2400

aggaagcccg acggcgccat ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg     2460

gacaccaagg cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag     2520

aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag     2580

gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca cttcaagggc     2640

aactacaagg cccagctgac caggctgaac cacatcacca actgcaacgg cgccgtgctg     2700

tccgtggagg agctcctgat cggcggcgag atgatcaagg ccggcaccct gaccctggag     2760

gaggtgagga ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa           2814


<210>  72
<211>  2832
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE-nuclease sequence

<400>  72
atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc       60

gagagacagc acatggacag catcgatatc gccgatctac gcacgctcgg ctacagccag      120

cagcaacagg agaagatcaa accgaaggtt cgttcgacag tggcgcagca ccacgaggca      180

ctggtcggcc acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg      240

ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga ggcgacacac      300

gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac gcgctctgga ggccttgctc      360

acggtggcgg gagagttgag aggtccaccg ttacagttgg acacaggcca acttctcaag      420

attgcaaaac gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg caatgcactg      480

acgggtgccc cgctcaactt gaccccccag caggtggtgg ccatcgccag caataatggt      540

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc      600

ttgacccccc agcaggtggt ggccatcgcc agcaatggcg gtggcaagca ggcgctggag      660

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg      720

gtggccatcg ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg      780

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat      840

aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc      900

cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg caagcaggcg      960

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag     1020

caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg     1080

ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc     1140

agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc     1200

caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaatgg cggtggcaag     1260

caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc     1320

ccccagcagg tggtggccat cgccagcaat ggcggtggca agcaggcgct ggagacggtc     1380

cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc     1440

atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg     1500

ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag caataatggt     1560

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc     1620

ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag     1680

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg     1740

gtggccatcg ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg     1800

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat     1860

ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc     1920

cacggcttga ccccccagca ggtggtggcc atcgccagca ataatggtgg caagcaggcg     1980

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gacccctcag     2040

caggtggtgg ccatcgccag caatggcggc ggcaggccgg cgctggagag cattgttgcc     2100

cagttatctc gccctgatcc ggcgttggcc gcgttgacca acgaccacct cgtcgccttg     2160

gcctgcctcg gcgggcgtcc tgcgctggat gcagtgaaaa agggattggg ggatcctatc     2220

agccgttccc agctggtgaa gtccgagctg gaggagaaga aatccgagtt gaggcacaag     2280

ctgaagtacg tgccccacga gtacatcgag ctgatcgaga tcgcccggaa cagcacccag     2340

gaccgtatcc tggagatgaa ggtgatggag ttcttcatga aggtgtacgg ctacaggggc     2400

aagcacctgg gcggctccag gaagcccgac ggcgccatct acaccgtggg ctcccccatc     2460

gactacggcg tgatcgtgga caccaaggcc tactccggcg gctacaacct gcccatcggc     2520

caggccgacg aaatgcagag gtacgtggag gagaaccaga ccaggaacaa gcacatcaac     2580

cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg     2640

tccggccact tcaagggcaa ctacaaggcc cagctgacca ggctgaacca catcaccaac     2700

tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg gcggcgagat gatcaaggcc     2760

ggcaccctga ccctggagga ggtgaggagg aagttcaaca acggcgagat caacttcgcg     2820

gccgactgat aa                                                         2832


<210>  73
<211>  2814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE-nuclease sequence

<400>  73
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac       60

gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc      120

aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt      180

acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc      240

aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc      300

ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg      360

agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc      420

gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac      480

ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag      540

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg      600

gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg      660

ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac      720

gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc      780

cacggcttga ccccggagca ggtggtggcc atcgccagca atattggtgg caagcaggcg      840

ctggagacgg tgcaggcgct gttgccggtg ctgtgccagg cccacggctt gaccccggag      900

caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg      960

ctgttgccgg tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc     1020

agccacgatg gcggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc     1080

caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagccacga tggcggcaag     1140

caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc     1200

ccccagcagg tggtggccat cgccagcaat aatggtggca agcaggcgct ggagacggtc     1260

cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc     1320

atcgccagca atattggtgg caagcaggcg ctggagacgg tgcaggcgct gttgccggtg     1380

ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag caataatggt     1440

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc     1500

ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag     1560

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg     1620

gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca gcggctgttg     1680

ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac     1740

gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc     1800

cacggcttga ccccccagca ggtggtggcc atcgccagca ataatggtgg caagcaggcg     1860

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag     1920

caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg     1980

ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc     2040

agcaatggcg gcggcaggcc ggcgctggag agcattgttg cccagttatc tcgccctgat     2100

ccggcgttgg ccgcgttgac caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt     2160

cctgcgctgg atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg     2220

aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac     2280

gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat cctggagatg     2340

aaggtgatgg agttcttcat gaaggtgtac ggctacaggg gcaagcacct gggcggctcc     2400

aggaagcccg acggcgccat ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg     2460

gacaccaagg cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag     2520

aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag     2580

gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca cttcaagggc     2640

aactacaagg cccagctgac caggctgaac cacatcacca actgcaacgg cgccgtgctg     2700

tccgtggagg agctcctgat cggcggcgag atgatcaagg ccggcaccct gaccctggag     2760

gaggtgagga ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa           2814


<210>  74
<211>  2832
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TALE-nuclease sequence

<400>  74
atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc       60

gagagacagc acatggacag catcgatatc gccgatctac gcacgctcgg ctacagccag      120

cagcaacagg agaagatcaa accgaaggtt cgttcgacag tggcgcagca ccacgaggca      180

ctggtcggcc acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg      240

ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga ggcgacacac      300

gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac gcgctctgga ggccttgctc      360

acggtggcgg gagagttgag aggtccaccg ttacagttgg acacaggcca acttctcaag      420

attgcaaaac gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg caatgcactg      480

acgggtgccc cgctcaactt gaccccccag caggtggtgg ccatcgccag caataatggt      540

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc      600

ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag      660

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg      720

gtggccatcg ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg      780

ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagcaat      840

attggtggca agcaggcgct ggagacggtg caggcgctgt tgccggtgct gtgccaggcc      900

cacggcttga ccccccagca ggtggtggcc atcgccagca ataatggtgg caagcaggcg      960

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag     1020

caggtggtgg ccatcgccag caatattggt ggcaagcagg cgctggagac ggtgcaggcg     1080

ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc     1140

agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc     1200

caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagccacga tggcggcaag     1260

caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc     1320

ccccagcagg tggtggccat cgccagcaat ggcggtggca agcaggcgct ggagacggtc     1380

cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc     1440

atcgccagcc acgatggcgg caagcaggcg ctggagacgg tccagcggct gttgccggtg     1500

ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag caatggcggt     1560

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc     1620

ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag     1680

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg     1740

gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg     1800

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat     1860

ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc     1920

cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg     1980

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gacccctcag     2040

caggtggtgg ccatcgccag caatggcggc ggcaggccgg cgctggagag cattgttgcc     2100

cagttatctc gccctgatcc ggcgttggcc gcgttgacca acgaccacct cgtcgccttg     2160

gcctgcctcg gcgggcgtcc tgcgctggat gcagtgaaaa agggattggg ggatcctatc     2220

agccgttccc agctggtgaa gtccgagctg gaggagaaga aatccgagtt gaggcacaag     2280

ctgaagtacg tgccccacga gtacatcgag ctgatcgaga tcgcccggaa cagcacccag     2340

gaccgtatcc tggagatgaa ggtgatggag ttcttcatga aggtgtacgg ctacaggggc     2400

aagcacctgg gcggctccag gaagcccgac ggcgccatct acaccgtggg ctcccccatc     2460

gactacggcg tgatcgtgga caccaaggcc tactccggcg gctacaacct gcccatcggc     2520

caggccgacg aaatgcagag gtacgtggag gagaaccaga ccaggaacaa gcacatcaac     2580

cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg     2640

tccggccact tcaagggcaa ctacaaggcc cagctgacca ggctgaacca catcaccaac     2700

tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg gcggcgagat gatcaaggcc     2760

ggcaccctga ccctggagga ggtgaggagg aagttcaaca acggcgagat caacttcgcg     2820

gccgactgat aa                                                         2832


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  75
atcactggca tctggactcc a                                                 21


<210>  76
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  76
agagccccta ccagaaccag ac                                                22


<210>  77
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  77
ggacctagta acataattgt gc                                                22


<210>  78
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  78
cctcatgtct agcacagttt                                                   20


<210>  79
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  79
accagctcag ctccacgtgg t                                                 21


<210>  80
<211>  58
<212>  DNA
<213>  Homo sapiens

<400>  80
tctcgctccg tggccttagc tgtgctcgcg ctactctctc tttctggcct ggaggcta         58


<210>  81
<211>  2814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta2M T01- TALEN - LEFT

<400>  81
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac       60

gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc      120

aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt      180

acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc      240

aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc      300

ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg      360

agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc      420

gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac      480

ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag      540

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg      600

gtggccatcg ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg      660

ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac      720

gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc      780

cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg caagcaggcg      840

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccccag      900

caggtggtgg ccatcgccag caatggcggt ggcaagcagg cgctggagac ggtccagcgg      960

ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc     1020

agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc     1080

caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagcaatat tggtggcaag     1140

caggcgctgg agacggtgca ggcgctgttg ccggtgctgt gccaggccca cggcttgacc     1200

ccccagcagg tggtggccat cgccagcaat aatggtggca agcaggcgct ggagacggtc     1260

cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc     1320

atcgccagcc acgatggcgg caagcaggcg ctggagacgg tccagcggct gttgccggtg     1380

ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag caatggcggt     1440

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc     1500

ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag     1560

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg     1620

gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca gcggctgttg     1680

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat     1740

aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc     1800

cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg caagcaggcg     1860

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccccag     1920

caggtggtgg ccatcgccag caatggcggt ggcaagcagg cgctggagac ggtccagcgg     1980

ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc     2040

agcaatggcg gcggcaggcc ggcgctggag agcattgttg cccagttatc tcgccctgat     2100

ccggcgttgg ccgcgttgac caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt     2160

cctgcgctgg atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg     2220

aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac     2280

gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat cctggagatg     2340

aaggtgatgg agttcttcat gaaggtgtac ggctacaggg gcaagcacct gggcggctcc     2400

aggaagcccg acggcgccat ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg     2460

gacaccaagg cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag     2520

aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag     2580

gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca cttcaagggc     2640

aactacaagg cccagctgac caggctgaac cacatcacca actgcaacgg cgccgtgctg     2700

tccgtggagg agctcctgat cggcggcgag atgatcaagg ccggcaccct gaccctggag     2760

gaggtgagga ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa           2814


<210>  82
<211>  2832
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta2M T01 TALEN -RIGHT

<400>  82
atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc       60

gagagacagc acatggacag catcgatatc gccgatctac gcacgctcgg ctacagccag      120

cagcaacagg agaagatcaa accgaaggtt cgttcgacag tggcgcagca ccacgaggca      180

ctggtcggcc acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg      240

ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga ggcgacacac      300

gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac gcgctctgga ggccttgctc      360

acggtggcgg gagagttgag aggtccaccg ttacagttgg acacaggcca acttctcaag      420

attgcaaaac gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg caatgcactg      480

acgggtgccc cgctcaactt gaccccggag caggtggtgg ccatcgccag caatattggt      540

ggcaagcagg cgctggagac ggtgcaggcg ctgttgccgg tgctgtgcca ggcccacggc      600

ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag      660

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg      720

gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg      780

ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac      840

gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc      900

cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg      960

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag     1020

caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg     1080

ctgttgccgg tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc     1140

agccacgatg gcggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc     1200

caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagcaatat tggtggcaag     1260

caggcgctgg agacggtgca ggcgctgttg ccggtgctgt gccaggccca cggcttgacc     1320

ccccagcagg tggtggccat cgccagcaat aatggtggca agcaggcgct ggagacggtc     1380

cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc     1440

atcgccagca ataatggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg     1500

ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag ccacgatggc     1560

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc     1620

ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag     1680

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg     1740

gtggccatcg ccagcaatat tggtggcaag caggcgctgg agacggtgca ggcgctgttg     1800

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat     1860

aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc     1920

cacggcttga ccccggagca ggtggtggcc atcgccagca atattggtgg caagcaggcg     1980

ctggagacgg tgcaggcgct gttgccggtg ctgtgccagg cccacggctt gacccctcag     2040

caggtggtgg ccatcgccag caatggcggc ggcaggccgg cgctggagag cattgttgcc     2100

cagttatctc gccctgatcc ggcgttggcc gcgttgacca acgaccacct cgtcgccttg     2160

gcctgcctcg gcgggcgtcc tgcgctggat gcagtgaaaa agggattggg ggatcctatc     2220

agccgttccc agctggtgaa gtccgagctg gaggagaaga aatccgagtt gaggcacaag     2280

ctgaagtacg tgccccacga gtacatcgag ctgatcgaga tcgcccggaa cagcacccag     2340

gaccgtatcc tggagatgaa ggtgatggag ttcttcatga aggtgtacgg ctacaggggc     2400

aagcacctgg gcggctccag gaagcccgac ggcgccatct acaccgtggg ctcccccatc     2460

gactacggcg tgatcgtgga caccaaggcc tactccggcg gctacaacct gcccatcggc     2520

caggccgacg aaatgcagag gtacgtggag gagaaccaga ccaggaacaa gcacatcaac     2580

cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg     2640

tccggccact tcaagggcaa ctacaaggcc cagctgacca ggctgaacca catcaccaac     2700

tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg gcggcgagat gatcaaggcc     2760

ggcaccctga ccctggagga ggtgaggagg aagttcaaca acggcgagat caacttcgcg     2820

gccgactgat aa                                                         2832


<210>  83
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M T02- TALEN targeting sequence

<400>  83
tccaaagatt caggtttact cacgtcatcc agcagagaat ggaaagtcaa                  50


<210>  84
<211>  2814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta2M T02-TALEN - LEFT

<400>  84
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac       60

gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc      120

aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt      180

acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc      240

aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc      300

ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg      360

agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc      420

gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac      480

ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag      540

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg      600

gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg      660

ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagcaat      720

attggtggca agcaggcgct ggagacggtg caggcgctgt tgccggtgct gtgccaggcc      780

cacggcttga ccccggagca ggtggtggcc atcgccagca atattggtgg caagcaggcg      840

ctggagacgg tgcaggcgct gttgccggtg ctgtgccagg cccacggctt gaccccggag      900

caggtggtgg ccatcgccag caatattggt ggcaagcagg cgctggagac ggtgcaggcg      960

ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc     1020

agcaataatg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc     1080

caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagcaatat tggtggcaag     1140

caggcgctgg agacggtgca ggcgctgttg ccggtgctgt gccaggccca cggcttgacc     1200

ccccagcagg tggtggccat cgccagcaat ggcggtggca agcaggcgct ggagacggtc     1260

cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc     1320

atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg     1380

ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag ccacgatggc     1440

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc     1500

ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca ggcgctggag     1560

acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg     1620

gtggccatcg ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg     1680

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat     1740

aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc     1800

cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg     1860

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccccag     1920

caggtggtgg ccatcgccag caatggcggt ggcaagcagg cgctggagac ggtccagcgg     1980

ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc     2040

agcaatggcg gcggcaggcc ggcgctggag agcattgttg cccagttatc tcgccctgat     2100

ccggcgttgg ccgcgttgac caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt     2160

cctgcgctgg atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg     2220

aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac     2280

gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat cctggagatg     2340

aaggtgatgg agttcttcat gaaggtgtac ggctacaggg gcaagcacct gggcggctcc     2400

aggaagcccg acggcgccat ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg     2460

gacaccaagg cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag     2520

aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag     2580

gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca cttcaagggc     2640

aactacaagg cccagctgac caggctgaac cacatcacca actgcaacgg cgccgtgctg     2700

tccgtggagg agctcctgat cggcggcgag atgatcaagg ccggcaccct gaccctggag     2760

gaggtgagga ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa           2814


<210>  85
<211>  2832
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta2M T02-TALEN  RIGHT

<400>  85
atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc       60

gagagacagc acatggacag catcgatatc gccgatctac gcacgctcgg ctacagccag      120

cagcaacagg agaagatcaa accgaaggtt cgttcgacag tggcgcagca ccacgaggca      180

ctggtcggcc acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg      240

ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga ggcgacacac      300

gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac gcgctctgga ggccttgctc      360

acggtggcgg gagagttgag aggtccaccg ttacagttgg acacaggcca acttctcaag      420

attgcaaaac gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg caatgcactg      480

acgggtgccc cgctcaactt gaccccccag caggtggtgg ccatcgccag caataatggt      540

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc      600

ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca ggcgctggag      660

acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg      720

gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg      780

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat      840

ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc      900

cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg      960

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccccag     1020

caggtggtgg ccatcgccag caatggcggt ggcaagcagg cgctggagac ggtccagcgg     1080

ctgttgccgg tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc     1140

agccacgatg gcggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc     1200

caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagccacga tggcggcaag     1260

caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc     1320

ccggagcagg tggtggccat cgccagcaat attggtggca agcaggcgct ggagacggtg     1380

caggcgctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc     1440

atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg     1500

ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag caatggcggt     1560

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc     1620

ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag     1680

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg     1740

gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca gcggctgttg     1800

ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac     1860

gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc     1920

cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg     1980

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gacccctcag     2040

caggtggtgg ccatcgccag caatggcggc ggcaggccgg cgctggagag cattgttgcc     2100

cagttatctc gccctgatcc ggcgttggcc gcgttgacca acgaccacct cgtcgccttg     2160

gcctgcctcg gcgggcgtcc tgcgctggat gcagtgaaaa agggattggg ggatcctatc     2220

agccgttccc agctggtgaa gtccgagctg gaggagaaga aatccgagtt gaggcacaag     2280

ctgaagtacg tgccccacga gtacatcgag ctgatcgaga tcgcccggaa cagcacccag     2340

gaccgtatcc tggagatgaa ggtgatggag ttcttcatga aggtgtacgg ctacaggggc     2400

aagcacctgg gcggctccag gaagcccgac ggcgccatct acaccgtggg ctcccccatc     2460

gactacggcg tgatcgtgga caccaaggcc tactccggcg gctacaacct gcccatcggc     2520

caggccgacg aaatgcagag gtacgtggag gagaaccaga ccaggaacaa gcacatcaac     2580

cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg     2640

tccggccact tcaagggcaa ctacaaggcc cagctgacca ggctgaacca catcaccaac     2700

tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg gcggcgagat gatcaaggcc     2760

ggcaccctga ccctggagga ggtgaggagg aagttcaaca acggcgagat caacttcgcg     2820

gccgactgat aa                                                         2832


<210>  86
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M T03- TALEN targeting sequence

<400>  86
ttagctgtgc tcgcgctact ctctctttct ggcctggagg ctatcca                     47


<210>  87
<211>  2814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta2M T03-TALEN - LEFT

<400>  87
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac       60

gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc      120

aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt      180

acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc      240

aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc      300

ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg      360

agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc      420

gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac      480

ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca ggcgctggag      540

acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg      600

gtggccatcg ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg      660

ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac      720

gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc      780

cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg      840

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccccag      900

caggtggtgg ccatcgccag caataatggt ggcaagcagg cgctggagac ggtccagcgg      960

ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc     1020

agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc     1080

caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaataa tggtggcaag     1140

caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc     1200

ccggagcagg tggtggccat cgccagccac gatggcggca agcaggcgct ggagacggtc     1260

cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc     1320

atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg     1380

ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag ccacgatggc     1440

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc     1500

ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag     1560

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg     1620

gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg     1680

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat     1740

aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc     1800

cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg caagcaggcg     1860

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccccag     1920

caggtggtgg ccatcgccag caatggcggt ggcaagcagg cgctggagac ggtccagcgg     1980

ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc     2040

agcaatggcg gcggcaggcc ggcgctggag agcattgttg cccagttatc tcgccctgat     2100

ccggcgttgg ccgcgttgac caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt     2160

cctgcgctgg atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg     2220

aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac     2280

gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat cctggagatg     2340

aaggtgatgg agttcttcat gaaggtgtac ggctacaggg gcaagcacct gggcggctcc     2400

aggaagcccg acggcgccat ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg     2460

gacaccaagg cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag     2520

aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag     2580

gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca cttcaagggc     2640

aactacaagg cccagctgac caggctgaac cacatcacca actgcaacgg cgccgtgctg     2700

tccgtggagg agctcctgat cggcggcgag atgatcaagg ccggcaccct gaccctggag     2760

gaggtgagga ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa           2814


<210>  88
<211>  2832
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta2M T03-TALEN -RIGHT

<400>  88
atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc       60

gagagacagc acatggacag catcgatatc gccgatctac gcacgctcgg ctacagccag      120

cagcaacagg agaagatcaa accgaaggtt cgttcgacag tggcgcagca ccacgaggca      180

ctggtcggcc acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg      240

ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga ggcgacacac      300

gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac gcgctctgga ggccttgctc      360

acggtggcgg gagagttgag aggtccaccg ttacagttgg acacaggcca acttctcaag      420

attgcaaaac gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg caatgcactg      480

acgggtgccc cgctcaactt gaccccccag caggtggtgg ccatcgccag caataatggt      540

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc      600

ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag      660

acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg      720

gtggccatcg ccagcaatat tggtggcaag caggcgctgg agacggtgca ggcgctgttg      780

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat      840

ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc      900

cacggcttga ccccggagca ggtggtggcc atcgccagca atattggtgg caagcaggcg      960

ctggagacgg tgcaggcgct gttgccggtg ctgtgccagg cccacggctt gaccccccag     1020

caggtggtgg ccatcgccag caataatggt ggcaagcagg cgctggagac ggtccagcgg     1080

ctgttgccgg tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc     1140

agccacgatg gcggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc     1200

caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagccacga tggcggcaag     1260

caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc     1320

ccccagcagg tggtggccat cgccagcaat ggcggtggca agcaggcgct ggagacggtc     1380

cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc     1440

atcgccagcc acgatggcgg caagcaggcg ctggagacgg tccagcggct gttgccggtg     1500

ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag ccacgatggc     1560

ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc     1620

ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca ggcgctggag     1680

acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg     1740

gtggccatcg ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg     1800

ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat     1860

aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc     1920

cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg caagcaggcg     1980

ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gacccctcag     2040

caggtggtgg ccatcgccag caatggcggc ggcaggccgg cgctggagag cattgttgcc     2100

cagttatctc gccctgatcc ggcgttggcc gcgttgacca acgaccacct cgtcgccttg     2160

gcctgcctcg gcgggcgtcc tgcgctggat gcagtgaaaa agggattggg ggatcctatc     2220

agccgttccc agctggtgaa gtccgagctg gaggagaaga aatccgagtt gaggcacaag     2280

ctgaagtacg tgccccacga gtacatcgag ctgatcgaga tcgcccggaa cagcacccag     2340

gaccgtatcc tggagatgaa ggtgatggag ttcttcatga aggtgtacgg ctacaggggc     2400

aagcacctgg gcggctccag gaagcccgac ggcgccatct acaccgtggg ctcccccatc     2460

gactacggcg tgatcgtgga caccaaggcc tactccggcg gctacaacct gcccatcggc     2520

caggccgacg aaatgcagag gtacgtggag gagaaccaga ccaggaacaa gcacatcaac     2580

cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg     2640

tccggccact tcaagggcaa ctacaaggcc cagctgacca ggctgaacca catcaccaac     2700

tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg gcggcgagat gatcaaggcc     2760

ggcaccctga ccctggagga ggtgaggagg aagttcaaca acggcgagat caacttcgcg     2820

gccgactgat aa                                                         2832


<210>  89
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric B2M-UL18

<400>  89

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu 
            20                  25                  30          


Leu Ser Leu Ser Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln 
        35                  40                  45              


Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn 
    50                  55                  60                  


Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu 
65                  70                  75                  80  


Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe 
                85                  90                  95      


Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro 
            100                 105                 110         


Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser 
        115                 120                 125             


Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
145                 150                 155                 160 


Thr Met Trp Cys Leu Thr Leu Phe Val Leu Trp Met Leu Arg Val Val 
                165                 170                 175     


Gly Met His Val Leu Arg Tyr Gly Tyr Thr Gly Ile Phe Asp Asp Thr 
            180                 185                 190         


Ser His Met Thr Leu Thr Val Val Gly Ile Phe Asp Gly Gln His Phe 
        195                 200                 205             


Phe Thr Tyr His Val Asn Ser Ser Asp Lys Ala Ser Ser Arg Ala Asn 
    210                 215                 220                 


Gly Thr Ile Ser Trp Met Ala Asn Val Ser Ala Ala Tyr Pro Thr Tyr 
225                 230                 235                 240 


Leu Asp Gly Glu Arg Ala Lys Gly Asp Leu Ile Phe Asn Gln Thr Glu 
                245                 250                 255     


Gln Asn Leu Leu Glu Leu Glu Ile Ala Leu Gly Tyr Arg Ser Gln Ser 
            260                 265                 270         


Val Leu Thr Trp Thr His Glu Cys Asn Thr Thr Glu Asn Gly Ser Phe 
        275                 280                 285             


Val Ala Gly Tyr Glu Gly Phe Gly Trp Asp Gly Glu Thr Leu Met Glu 
    290                 295                 300                 


Leu Lys Asp Asn Leu Thr Leu Trp Thr Gly Pro Asn Tyr Glu Ile Ser 
305                 310                 315                 320 


Trp Leu Lys Gln Asn Lys Thr Tyr Ile Asp Gly Lys Ile Lys Asn Ile 
                325                 330                 335     


Ser Glu Gly Asp Thr Thr Ile Gln Arg Asn Tyr Leu Lys Gly Asn Cys 
            340                 345                 350         


Thr Gln Trp Ser Val Ile Tyr Ser Gly Phe Gln Thr Pro Val Thr His 
        355                 360                 365             


Pro Val Val Lys Gly Gly Val Arg Asn Gln Asn Asp Asn Arg Ala Glu 
    370                 375                 380                 


Ala Phe Cys Thr Ser Tyr Gly Phe Phe Pro Gly Glu Ile Asn Ile Thr 
385                 390                 395                 400 


Phe Ile His Tyr Gly Asn Lys Ala Pro Asp Asp Ser Glu Pro Gln Cys 
                405                 410                 415     


Asn Pro Leu Leu Pro Thr Phe Asp Gly Thr Phe His Gln Gly Cys Tyr 
            420                 425                 430         


Val Ala Ile Phe Cys Asn Gln Asn Tyr Thr Cys Arg Val Thr His Gly 
        435                 440                 445             


Asn Trp Thr Val Glu Ile Pro Ile Ser Val Thr Ser Pro Asp Asp Ser 
    450                 455                 460                 


Ser Ser Gly Glu Val Pro Asp His Pro Thr Ala Asn Lys Arg Tyr Asn 
465                 470                 475                 480 


Thr Met Thr Ile Ser Ser Val Leu Leu Ala Leu Leu Leu Cys Ala Leu 
                485                 490                 495     


Leu Phe Ala Phe Leu His Tyr Phe Thr Thr Leu Lys Gln Tyr Leu Arg 
            500                 505                 510         


Asn Leu Ala Phe Ala Trp Arg Tyr Arg Lys Val Arg Ser Ser 
        515                 520                 525     


<210>  90
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP-MICAed

<400>  90

Met Gly Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu 
1               5                   10                  15      


Ala Leu Leu Phe Pro Ser Met Ala Ser Met Glu Pro His Ser Leu Arg 
            20                  25                  30          


Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe 
        35                  40                  45              


Leu Thr Glu Val His Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg 
    50                  55                  60                  


Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu 
65                  70                  75                  80  


Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly 
                85                  90                  95      


Lys Asp Leu Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly 
            100                 105                 110         


Leu His Ser Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn 
        115                 120                 125             


Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu 
    130                 135                 140                 


Ser Gln Asn Leu Glu Thr Lys Glu Trp Thr Met Pro Gln Ser Ser Arg 
145                 150                 155                 160 


Ala Gln Thr Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala 
                165                 170                 175     


Met Lys Thr Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln 
            180                 185                 190         


Glu Leu Arg Arg Tyr Leu Lys Ser Gly Val Val Leu Arg Arg Thr Val 
        195                 200                 205             


Pro Pro Met Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile 
    210                 215                 220                 


Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu 
225                 230                 235                 240 


Ser Trp Arg Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp 
                245                 250                 255     


Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala 
            260                 265                 270         


Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu 
        275                 280                 285             


His Ser Gly Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu 
    290                 295                 300                 


Val Leu Gln Ser His Trp 
305                 310 


<210>  91
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP-MICBed

<400>  91

Met Gly Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu 
1               5                   10                  15      


Ala Leu Leu Phe Pro Ser Met Ala Ser Met Ala Glu Pro His Ser Leu 
            20                  25                  30          


Arg Tyr Asn Leu Met Val Leu Ser Gln Asp Glu Ser Val Gln Ser Gly 
        35                  40                  45              


Phe Leu Ala Glu Gly His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp 
    50                  55                  60                  


Arg Gln Lys Arg Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val 
65                  70                  75                  80  


Leu Gly Ala Lys Thr Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn 
                85                  90                  95      


Gly Gln Asp Leu Arg Arg Thr Leu Thr His Ile Lys Asp Gln Lys Gly 
            100                 105                 110         


Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp 
        115                 120                 125             


Ser Ser Thr Arg Gly Ser Arg His Phe Tyr Tyr Asp Gly Glu Leu Phe 
    130                 135                 140                 


Leu Ser Gln Asn Leu Glu Thr Gln Glu Ser Thr Val Pro Gln Ser Ser 
145                 150                 155                 160 


Arg Ala Gln Thr Leu Ala Met Asn Val Thr Asn Phe Trp Lys Glu Asp 
                165                 170                 175     


Ala Met Lys Thr Lys Thr His Tyr Arg Ala Met Gln Ala Asp Cys Leu 
            180                 185                 190         


Gln Lys Leu Gln Arg Tyr Leu Lys Ser Gly Val Ala Ile Arg Arg Thr 
        195                 200                 205             


Val Pro Pro Met Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly Asn 
    210                 215                 220                 


Ile Thr Val Thr Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr 
225                 230                 235                 240 


Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln 
                245                 250                 255     


Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val 
            260                 265                 270         


Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met 
        275                 280                 285             


Glu His Ser Gly Asn His Gly Thr His Pro Val Pro Ser Gly Lys Val 
    290                 295                 300                 


Leu Val Leu Gln Ser Gln Arg Thr Asp 
305                 310             


<210>  92
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP-ULBP1ed

<400>  92

Met Gly Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu 
1               5                   10                  15      


Ala Leu Leu Phe Pro Ser Met Ala Ser Met Gly Trp Val Asp Thr His 
            20                  25                  30          


Cys Leu Cys Tyr Asp Phe Ile Ile Thr Pro Lys Ser Arg Pro Glu Pro 
        35                  40                  45              


Gln Trp Cys Glu Val Gln Gly Leu Val Asp Glu Arg Pro Phe Leu His 
    50                  55                  60                  


Tyr Asp Cys Val Asn His Lys Ala Lys Ala Phe Ala Ser Leu Gly Lys 
65                  70                  75                  80  


Lys Val Asn Val Thr Lys Thr Trp Glu Glu Gln Thr Glu Thr Leu Arg 
                85                  90                  95      


Asp Val Val Asp Phe Leu Lys Gly Gln Leu Leu Asp Ile Gln Val Glu 
            100                 105                 110         


Asn Leu Ile Pro Ile Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys 
        115                 120                 125             


Glu His Glu Ala His Gly His Gly Arg Gly Ser Trp Gln Phe Leu Phe 
    130                 135                 140                 


Asn Gly Gln Lys Phe Leu Leu Phe Asp Ser Asn Asn Arg Lys Trp Thr 
145                 150                 155                 160 


Ala Leu His Pro Gly Ala Lys Lys Met Thr Glu Lys Trp Glu Lys Asn 
                165                 170                 175     


Arg Asp Val Thr Met Phe Phe Gln Lys Ile Ser Leu Gly Asp Cys Lys 
            180                 185                 190         


Met Trp Leu Glu Glu Phe Leu Met Tyr Trp Glu Gln Met Leu Asp Pro 
        195                 200                 205             


Thr 
    


<210>  93
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP-ULBP2ed

<400>  93

Met Gly Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu 
1               5                   10                  15      


Ala Leu Leu Phe Pro Ser Met Ala Ser Met Gly Arg Ala Asp Pro His 
            20                  25                  30          


Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro 
        35                  40                  45              


Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His 
    50                  55                  60                  


Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro Val Leu Arg 
                85                  90                  95      


Glu Val Val Asp Ile Leu Thr Glu Gln Leu Arg Asp Ile Gln Leu Glu 
            100                 105                 110         


Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys 
        115                 120                 125             


Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln Phe Ser Phe 
    130                 135                 140                 


Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg Met Trp Thr 
145                 150                 155                 160 


Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp 
                165                 170                 175     


Lys Val Val Ala Met Ser Phe His Tyr Phe Ser Met Gly Asp Cys Ile 
            180                 185                 190         


Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro 
        195                 200                 205             


Ser Ala Gly 
    210     


<210>  94
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP-ULBP3ed

<400>  94

Met Gly Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu 
1               5                   10                  15      


Ala Leu Leu Phe Pro Ser Met Ala Ser Met Asp Ala His Ser Leu Trp 
            20                  25                  30          


Tyr Asn Phe Thr Ile Ile His Leu Pro Arg His Gly Gln Gln Trp Cys 
        35                  40                  45              


Glu Val Gln Ser Gln Val Asp Gln Lys Asn Phe Leu Ser Tyr Asp Cys 
    50                  55                  60                  


Gly Ser Asp Lys Val Leu Ser Met Gly His Leu Glu Glu Gln Leu Tyr 
65                  70                  75                  80  


Ala Thr Asp Ala Trp Gly Lys Gln Leu Glu Met Leu Arg Glu Val Gly 
                85                  90                  95      


Gln Arg Leu Arg Leu Glu Leu Ala Asp Thr Glu Leu Glu Asp Phe Thr 
            100                 105                 110         


Pro Ser Gly Pro Leu Thr Leu Gln Val Arg Met Ser Cys Glu Cys Glu 
        115                 120                 125             


Ala Asp Gly Tyr Ile Arg Gly Ser Trp Gln Phe Ser Phe Asp Gly Arg 
    130                 135                 140                 


Lys Phe Leu Leu Phe Asp Ser Asn Asn Arg Lys Trp Thr Val Val His 
145                 150                 155                 160 


Ala Gly Ala Arg Arg Met Lys Glu Lys Trp Glu Lys Asp Ser Gly Leu 
                165                 170                 175     


Thr Thr Phe Phe Lys Met Val Ser Met Arg Asp Cys Lys Ser Trp Leu 
            180                 185                 190         


Arg Asp Phe Leu Met His Arg Lys Lys Arg Leu Glu Pro Thr 
        195                 200                 205     


<210>  95
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP-N2DL4ed

<400>  95

Met Gly Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu 
1               5                   10                  15      


Ala Leu Leu Phe Pro Ser Met Ala Ser Met His Ser Leu Cys Phe Asn 
            20                  25                  30          


Phe Thr Ile Lys Ser Leu Ser Arg Pro Gly Gln Pro Trp Cys Glu Ala 
        35                  40                  45              


Gln Val Phe Leu Asn Lys Asn Leu Phe Leu Gln Tyr Asn Ser Asp Asn 
    50                  55                  60                  


Asn Met Val Lys Pro Leu Gly Leu Leu Gly Lys Lys Val Tyr Ala Thr 
65                  70                  75                  80  


Ser Thr Trp Gly Glu Leu Thr Gln Thr Leu Gly Glu Val Gly Arg Asp 
                85                  90                  95      


Leu Arg Met Leu Leu Cys Asp Ile Lys Pro Gln Ile Lys Thr Ser Asp 
            100                 105                 110         


Pro Ser Thr Leu Gln Val Glu Met Phe Cys Gln Arg Glu Ala Glu Arg 
        115                 120                 125             


Cys Thr Gly Ala Ser Trp Gln Phe Ala Thr Asn Gly Glu Lys Ser Leu 
    130                 135                 140                 


Leu Phe Asp Ala Met Asn Met Thr Trp Thr Val Ile Asn His Glu Ala 
145                 150                 155                 160 


Ser Lys Ile Lys Glu Thr Trp Lys Lys Asp Arg Gly Leu Glu Lys Tyr 
                165                 170                 175     


Phe Arg Lys Leu Ser Lys Gly Asp Cys Asp His Trp Leu Arg Glu Phe 
            180                 185                 190         


Leu Gly His Trp Glu Ala Met Pro Glu Pro Thr Val Ser Pro Val Asn 
        195                 200                 205             


Ala Ser Asp Ile His Trp Ser Ser Ser Ser Leu Pro Asp 
    210                 215                 220     


<210>  96
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP-RET1Ged

<400>  96

Met Gly Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu 
1               5                   10                  15      


Ala Leu Leu Phe Pro Ser Met Ala Ser Met Gly Leu Ala Asp Pro His 
            20                  25                  30          


Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro 
        35                  40                  45              


Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His 
    50                  55                  60                  


Tyr Asp Cys Gly Ser Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro Val Leu Arg 
                85                  90                  95      


Glu Val Val Asp Ile Leu Thr Glu Gln Leu Leu Asp Ile Gln Leu Glu 
            100                 105                 110         


Asn Tyr Ile Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys 
        115                 120                 125             


Glu Gln Lys Ala Glu Gly His Gly Ser Gly Ser Trp Gln Leu Ser Phe 
    130                 135                 140                 


Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Asn Arg Met Trp Thr 
145                 150                 155                 160 


Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp 
                165                 170                 175     


Lys Asp Met Thr Met Ser Phe His Tyr Ile Ser Met Gly Asp Cys Thr 
            180                 185                 190         


Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro 
        195                 200                 205             


Ser Ala Gly Ala Pro Pro Thr Met Ser Ser Gly Thr Ala Gln Pro Arg 
    210                 215                 220                 


<210>  97
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP-RAETILed

<400>  97

Met Gly Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu 
1               5                   10                  15      


Ala Leu Leu Phe Pro Ser Met Ala Ser Met Arg Arg Asp Asp Pro His 
            20                  25                  30          


Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro 
        35                  40                  45              


Arg Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His 
    50                  55                  60                  


Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Met Ala Trp Lys Ala Gln Asn Pro Val Leu Arg 
                85                  90                  95      


Glu Val Val Asp Ile Leu Thr Glu Gln Leu Leu Asp Ile Gln Leu Glu 
            100                 105                 110         


Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys 
        115                 120                 125             


Glu Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln Phe Ser Ile 
    130                 135                 140                 


Asp Gly Gln Thr Phe Leu Leu Phe Asp Ser Glu Lys Arg Met Trp Thr 
145                 150                 155                 160 


Thr Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp 
                165                 170                 175     


Lys Asp Val Ala Met Ser Phe His Tyr Ile Ser Met Gly Asp Cys Ile 
            180                 185                 190         


Gly Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro 
        195                 200                 205             


Ser Ala Gly 
    210     


