                         SEQUENCE LISTING

<110>  UNIVERSITY OF WARWICK
 
<120>  ASSAY AND TREATMENT

<130>  N400332WO

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  961
<212>  RNA
<213>  Human respiratory syncytial virus

<400>  1
ggggcaaaua ugucacgaag gaauccuugc aaauuugaaa uucgagguca uugcuuaaau       60

gguaagaggu gucauuuuag ucauaauuau uuugaauggc caccccaugc acugcuugua      120

agacaaaacu uuauguuaaa cagaauacuu aagucuaugg auaaaaguau agauaccuua      180

ucagaaauaa guggagcugc agaguuggac agaacagaag aguaugcucu ugguguaguu      240

ggagugcuag agaguuauau aggaucaaua aacaauauaa cuaaacaauc agcauguguu      300

gccaugagca aacuccucac ugaacucaau agugaugaua ucaaaaagcu gagggacaau      360

gaagagcuaa auucacccaa gauaagagug uacaauacug ucauaucaua uauugaaagc      420

aacaggaaaa acaauaaaca aacuauccau cuguuaaaaa gauugccagc agacguauug      480

aagaaaacca ucaaaaacac auuggauauc cauaagagca uaaccaucaa caacccaaaa      540

gaaucaacug uuagugauac aaaugaccau gccaaaaaua augauacuac cugacaaaua      600

uccuuguagu auaacuucca uacuaauaac aaguagaugu agaguuacua uguauaauca      660

aaagaacaca cuauauuuca aucaaaacaa cccaaauaac cauauguacu caccgaauca      720

aacauucaau gaaauccauu ggaccucuca agaauugauu gacacaauuc aaaauuuucu      780

acaacaucua gguauuauug aggauauaua uacaauauau auauuagugu cauaacacuc      840

aauucuaaca cucaccacau cguuacauua uuaauucaaa caauucaagu ugugggacaa      900

aauggauccc auuauuaaug gaaauucugc uaauguuuau cuaaccgaua guuauuuaaa      960

a                                                                      961


<210>  2
<211>  194
<212>  PRT
<213>  Human respiratory syncytial virus

<400>  2

Met Ser Arg Arg Asn Pro Cys Lys Phe Glu Ile Arg Gly His Cys Leu 
1               5                   10                  15      


Asn Gly Lys Arg Cys His Phe Ser His Asn Tyr Phe Glu Trp Pro Pro 
            20                  25                  30          


His Ala Leu Leu Val Arg Gln Asn Phe Met Leu Asn Arg Ile Leu Lys 
        35                  40                  45              


Ser Met Asp Lys Ser Ile Asp Thr Leu Ser Glu Ile Ser Gly Ala Ala 
    50                  55                  60                  


Glu Leu Asp Arg Thr Glu Glu Tyr Ala Leu Gly Val Val Gly Val Leu 
65                  70                  75                  80  


Glu Ser Tyr Ile Gly Ser Ile Asn Asn Ile Thr Lys Gln Ser Ala Cys 
                85                  90                  95      


Val Ala Met Ser Lys Leu Leu Thr Glu Leu Asn Ser Asp Asp Ile Lys 
            100                 105                 110         


Lys Leu Arg Asp Asn Glu Glu Leu Asn Ser Pro Lys Ile Arg Val Tyr 
        115                 120                 125             


Asn Thr Val Ile Ser Tyr Ile Glu Ser Asn Arg Lys Asn Asn Lys Gln 
    130                 135                 140                 


Thr Ile His Leu Leu Lys Arg Leu Pro Ala Asp Val Leu Lys Lys Thr 
145                 150                 155                 160 


Ile Lys Asn Thr Leu Asp Ile His Lys Ser Ile Thr Ile Asn Asn Pro 
                165                 170                 175     


Lys Glu Ser Thr Val Ser Asp Thr Asn Asp His Ala Lys Asn Asn Asp 
            180                 185                 190         


Thr Thr 
        


<210>  3
<211>  90
<212>  PRT
<213>  Human respiratory syncytial virus

<400>  3

Met Thr Met Pro Lys Ile Met Ile Leu Pro Asp Lys Tyr Pro Cys Ser 
1               5                   10                  15      


Ile Thr Ser Ile Leu Ile Thr Ser Arg Cys Arg Val Thr Met Tyr Asn 
            20                  25                  30          


Gln Lys Asn Thr Leu Tyr Phe Asn Gln Asn Asn Pro Asn Asn His Met 
        35                  40                  45              


Tyr Ser Pro Asn Gln Thr Phe Asn Glu Ile His Trp Thr Ser Gln Glu 
    50                  55                  60                  


Leu Ile Asp Thr Ile Gln Asn Phe Leu Gln His Leu Gly Ile Ile Glu 
65                  70                  75                  80  


Asp Ile Tyr Thr Ile Tyr Ile Leu Val Ser 
                85                  90  


<210>  4
<211>  961
<212>  RNA
<213>  Human respiratory syncytial virus

<400>  4
ggggcaaaua ugucacgaag gaauccuugc aaauuugaaa uucgagguca uugcuuaaau       60

gguaagaggu gucauuuuag ucauaauuau uuugaauggc caccccaugc acugcuugua      120

agacaaaacu uuauguuaaa cagaauacuu aagucuaugg auaaaaguau agauaccuua      180

ucagaaauaa guggagcugc agaguuggac agaacagaag aguaugcucu ugguguaguu      240

ggagugcuag agaguuauau aggaucaaua aacaauauaa cuaaacaauc agcauguguu      300

gccaugagca aacuccucac ugaacucaau agugaugaua ucaaaaagcu gagggacaau      360

gaagagcuaa auucacccaa gauaagagug uacaauacug ucauaucaua uauugaaagc      420

aacaggaaaa acaauaaaca aacuauccau cuguuaaaaa gauugccagc agacguauug      480

aagaaaacca ucaaaaacac auuggauauc cauaagagca uaaccaucaa caacccaaaa      540

gaaucaacug uuagugauac aaaugaccau gccaaaaaua augauacuac cugacaaaua      600

uccuuguagu auaacuucca uacuaauaac aaguagaugu agaguuacua uguauaauca      660

aaagaacaca cuauauuuca aucaaaacaa cccaaauaac cauauguacu caccgaauca      720

aacauucaau gaaauccauu ggaccucuca agaauugauu gacacaauuc aaaauuuucu      780

acaacaucua gguauuauug aggauauaua uacaauauau auauuagugu cauaacacuc      840

aauucuaaca cucaccacau cguuacauua uuaauucaaa caauucaagu ugugggacaa      900

aauggauccc auuauuaaug gaaauucugc uaauguuuau cuaaccgaua guuauuuaaa      960

a                                                                      961


<210>  5
<211>  874
<212>  RNA
<213>  Human respiratory syncytial virus

<400>  5
ggggcaaaua ugucgcgaag aaauccuugu aaauuugaga uuagagguca uugcuugaau       60

gguagaagau gucacuacag ucauaauuac uuugaauggc cuccucaugc cuuacuagug      120

aggcaaaacu ucauguuaaa caagauacuc aagucaaugg acaaaagcau agacacuuug      180

ucugaaauaa guggagcugc ugaacuggac agaacagaag aauaugcucu ugguauaguu      240

ggagugcuag agaguuacau aggaucuaua aacaacauaa caaaacaauc agcauguguu      300

gcuaugagua aacuucuuau ugagaucaau agugaugaca uuaaaaagcu gagagauaau      360

gaagaaccca auucaccuaa gauaagagug uacaauacug uuauaucaua cauugagagc      420

aauagaaaaa acaacaagca aacaauccau cugcucaaaa gacuaccagc agacgugcug      480

aagaagacaa uaaaaaacac auuagauauc cacaaaagca uaaucauaag caacccaaaa      540

gagucaaccg ugaaugauca aaaugaccaa accaaaaaua augauauuac cggauaaaua      600

uccuuguagu auaucaucca uauugauuuc aagugaaagc augauugcua cauucaauca      660

uaaaaacaua uuacaauuua accauaacca uuuggauaac caccagcguu uauuaaauaa      720

uauauuugau gaaauucauu ggacaccuaa aaacuuauua gaugccacuc aacaauuucu      780

ccaacaucuu aacaucccug aagauauaua uacaauauau auauuagugu cauaaugcuu      840

ggccauaacg auucuauauc auccaaccau aaaa                                  874


<210>  6
<211>  960
<212>  RNA
<213>  Bovine respiratory syncytial virus

<400>  6
ggggcaaaua ugucacgaag aaaucccugc aaauaugaga uuaggggaca uugcuuaaau       60

gguaaaaaau gucauuuuag ucauaauuac uuugaauggc cuccacaugc uuuauuagug      120

aggcaaaauu uuaugcuaaa uaagauauua aaaucuaugg acaggaacaa cgauacccug      180

ucagaaauaa guggugcagc agaguuggau agaacagaag aauaugcauu ggguguaaua      240

ggaguuuugg aaaguuaccu aggcucuauc aauaauauaa caaaacaauc agccuguguu      300

gcuaugagua aacuauuagc cgagauuaac aaugaugaca uaaagagauu gaggaacaag      360

gaagugccaa caucaccuaa gauaagaaua uauaacacag uuauaucaua uauugauagc      420

aacaagagaa acacaaaaca aacuauacau uugcuuaaga gauugccugc agacguacuu      480

aaaaagacaa ucaagaacac uauagauauu cacaacgaaa uaaaugguaa uaaccaaggu      540

gacauaauug uuaaugaaca aaaugaauaa cuccaacauu auuauuuucc cagaaaaaua      600

cccuuguagc auauccucuu ugcuaauuaa gaaugaaaau gauguuauug uacuaaguca      660

ucaaaauguu cuugacuacu uacaguuuca auauccaugu aauauguauu cucaaaauca      720

uaugcuugau gauaucuauu ggacaucaca ggagcuaauu gaggauguac uuaagauucu      780

ucaucuuucu ggcauaucca uaaguaagua ugugauauau guuuuagugc uauaguauau      840

aagucacuca acuauuaauc aacagccacu ucuucauagc uagcaauaua uaaggacaaa      900

auggauacac ucauucauga gaacucaacu aauguuuacu uaacagauag uuauuuaaaa      960


<210>  7
<211>  964
<212>  RNA
<213>  Ovine respiratory syncytial virus

<400>  7
ggggcaaaua ugucacgaag aaaucccugc aaauaugaga ucaggggaca uugcuuaaau       60

ggcaaaaaau gccauuucag ccauaauuac uuugaauggc cuccacaugc uuuauuagug      120

aggcaaaauu uuauguuaaa caagauauua aagucuaugg auaggagcaa ugauacucug      180

ucagagauaa guggagcugc agaauuagau agaacagagg aauaugcauu aggugugaua      240

ggaguuuuag aaaguuacuu gggcucuguu aauaacauaa caaaacaauc agcuuguguu      300

gcuaugagua aauuauuagg ugagauuaau agugaugaca ucaaaggauu aagaaacaaa      360

gaauugccaa cuucaccuaa gauaagaaua uauaacacag uuauaucaua uauugauagc      420

aacaagagaa acccaaaaca aacuauacau uuacuuaaaa gauugccugc agaugugcuu      480

aagaagacca ucaagaauac aauagauauu cacaaugaaa uaaauguuaa uaauccaagu      540

gacauaggug uuaaugaaca aaaugaauaa uuccaauauc auuauuuucc cagagaaaua      600

uccuuguagu auaucuucuu uguuaaucag agaugagaau aauguuauug uauuaaauca      660

ucagaauauu uuugacugcu cacagucuca acauccaugu gauauguauc cucaaaauca      720

uauacuugac uauaccuauu ggacaucaca ggaauugauu gacgauguac uaaagauucu      780

ucaccuuucu agcaucccca uaaauaggua uguggucuau gucuuagugc uguaguaugu      840

aaaucauuua acuuucaauc auuaucuaua uauuucuccu uguagccgga aauacaccag      900

aggacaaaau ggacucacuc auucaugaaa acucaaccaa uguauacuua acagauaguu      960

auuu                                                                   964


<210>  8
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser His Val Ala Val Glu Asn Ala Leu Gly Leu Asp Gln Gln Phe 
1               5                   10                  15      


Ala Gly Leu Asp Leu Asn Ser Ser Asp Asn Gln Ser Gly Gly Ser Thr 
            20                  25                  30          


Ala Ser Lys Gly Arg Tyr Ile Pro Pro His Leu Arg Asn Arg Glu Ala 
        35                  40                  45              


Thr Lys Gly Phe Tyr Asp Lys Asp Ser Ser Gly Trp Ser Ser Ser Lys 
    50                  55                  60                  


Asp Lys Asp Ala Tyr Ser Ser Phe Gly Ser Arg Ser Asp Ser Arg Gly 
65                  70                  75                  80  


Lys Ser Ser Phe Phe Ser Asp Arg Gly Ser Gly Ser Arg Gly Arg Phe 
                85                  90                  95      


Asp Asp Arg Gly Arg Ser Asp Tyr Asp Gly Ile Gly Ser Arg Gly Asp 
            100                 105                 110         


Arg Ser Gly Phe Gly Lys Phe Glu Arg Gly Gly Asn Ser Arg Trp Cys 
        115                 120                 125             


Asp Lys Ser Asp Glu Asp Asp Trp Ser Lys Pro Leu Pro Pro Ser Glu 
    130                 135                 140                 


Arg Leu Glu Gln Glu Leu Phe Ser Gly Gly Asn Thr Gly Ile Asn Phe 
145                 150                 155                 160 


Glu Lys Tyr Asp Asp Ile Pro Val Glu Ala Thr Gly Asn Asn Cys Pro 
                165                 170                 175     


Pro His Ile Glu Ser Phe Ser Asp Val Glu Met Gly Glu Ile Ile Met 
            180                 185                 190         


Gly Asn Ile Glu Leu Thr Arg Tyr Thr Arg Pro Thr Pro Val Gln Lys 
        195                 200                 205             


His Ala Ile Pro Ile Ile Lys Glu Lys Arg Asp Leu Met Ala Cys Ala 
    210                 215                 220                 


Gln Thr Gly Ser Gly Lys Thr Ala Ala Phe Leu Leu Pro Ile Leu Ser 
225                 230                 235                 240 


Gln Ile Tyr Ser Asp Gly Pro Gly Glu Ala Leu Arg Ala Met Lys Glu 
                245                 250                 255     


Asn Gly Arg Tyr Gly Arg Arg Lys Gln Tyr Pro Ile Ser Leu Val Leu 
            260                 265                 270         


Ala Pro Thr Arg Glu Leu Ala Val Gln Ile Tyr Glu Glu Ala Arg Lys 
        275                 280                 285             


Phe Ser Tyr Arg Ser Arg Val Arg Pro Cys Val Val Tyr Gly Gly Ala 
    290                 295                 300                 


Asp Ile Gly Gln Gln Ile Arg Asp Leu Glu Arg Gly Cys His Leu Leu 
305                 310                 315                 320 


Val Ala Thr Pro Gly Arg Leu Val Asp Met Met Glu Arg Gly Lys Ile 
                325                 330                 335     


Gly Leu Asp Phe Cys Lys Tyr Leu Val Leu Asp Glu Ala Asp Arg Met 
            340                 345                 350         


Leu Asp Met Gly Phe Glu Pro Gln Ile Arg Arg Ile Val Glu Gln Asp 
        355                 360                 365             


Thr Met Pro Pro Lys Gly Val Arg His Thr Met Met Phe Ser Ala Thr 
    370                 375                 380                 


Phe Pro Lys Glu Ile Gln Met Leu Ala Arg Asp Phe Leu Asp Glu Tyr 
385                 390                 395                 400 


Ile Phe Leu Ala Val Gly Arg Val Gly Ser Thr Ser Glu Asn Ile Thr 
                405                 410                 415     


Gln Lys Val Val Trp Val Glu Glu Ser Asp Lys Arg Ser Phe Leu Leu 
            420                 425                 430         


Asp Leu Leu Asn Ala Thr Gly Lys Asp Ser Leu Thr Leu Val Phe Val 
        435                 440                 445             


Glu Thr Lys Lys Gly Ala Asp Ser Leu Glu Asp Phe Leu Tyr His Glu 
    450                 455                 460                 


Gly Tyr Ala Cys Thr Ser Ile His Gly Asp Arg Ser Gln Arg Asp Arg 
465                 470                 475                 480 


Glu Glu Ala Leu His Gln Phe Arg Ser Gly Lys Ser Pro Ile Leu Val 
                485                 490                 495     


Ala Thr Ala Val Ala Ala Arg Gly Leu Asp Ile Ser Asn Val Lys His 
            500                 505                 510         


Val Ile Asn Phe Asp Leu Pro Ser Asp Ile Glu Glu Tyr Val His Arg 
        515                 520                 525             


Ile Gly Arg Thr Gly Arg Val Gly Asn Leu Gly Leu Ala Thr Ser Phe 
    530                 535                 540                 


Phe Asn Glu Arg Asn Ile Asn Ile Thr Lys Asp Leu Leu Asp Leu Leu 
545                 550                 555                 560 


Val Glu Ala Lys Gln Glu Val Pro Ser Trp Leu Glu Asn Met Ala Tyr 
                565                 570                 575     


Glu His His Tyr Lys Gly Ser Ser Arg Gly Arg Ser Lys Ser Ser Arg 
            580                 585                 590         


Phe Ser Gly Gly Phe Gly Ala Arg Asp Tyr Arg Gln Ser Ser Gly Ala 
        595                 600                 605             


Ser Ser Ser Ser Phe Ser Ser Ser Arg Ala Ser Ser Ser Arg Ser Gly 
    610                 615                 620                 


Gly Gly Gly His Gly Ser Ser Arg Gly Phe Gly Gly Gly Gly Tyr Gly 
625                 630                 635                 640 


Gly Phe Tyr Asn Ser Asp Gly Tyr Gly Gly Asn Tyr Asn Ser Gln Gly 
                645                 650                 655     


Val Asp Trp Trp Gly Asn 
            660         


<210>  9
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser His Val Ala Val Glu Asn Ala Leu Gly Leu Asp Gln Gln Phe 
1               5                   10                  15      


Ala Gly Leu Asp Leu Asn Ser Ser Asp Asn Gln Ser Gly Gly Ser Thr 
            20                  25                  30          


Ala Ser Lys Gly Arg Tyr Ile Pro Pro His Leu Arg Asn Arg Glu Ala 
        35                  40                  45              


Thr Lys Gly Phe Tyr Asp Lys Asp Ser Ser Gly Trp Ser Ser Ser Lys 
    50                  55                  60                  


Asp Lys Asp Ala Tyr Ser Ser Phe Gly Ser Arg Ser Asp Ser Arg Gly 
65                  70                  75                  80  


Lys Ser Ser Phe Phe Ser Asp Arg Gly Ser Gly Ser Arg Gly Arg Phe 
                85                  90                  95      


Asp Asp Arg Gly Arg Ser Asp Tyr Asp Gly Ile Gly Ser Arg Gly Asp 
            100                 105                 110         


Arg Ser Gly Phe Gly Lys Phe Glu Arg Gly Gly Asn Ser Arg Trp Cys 
        115                 120                 125             


Asp Lys Ser Asp Glu Asp Asp Trp Ser Lys Pro Leu Pro Pro Ser Glu 
    130                 135                 140                 


Arg Leu Glu Gln Glu Leu Phe Ser Gly Gly Asn Thr Gly Ile Asn Phe 
145                 150                 155                 160 


Glu Lys Tyr Asp Asp Ile Pro Val Glu Ala Thr Gly Asn Asn Cys Pro 
                165                 170                 175     


Pro His Ile Glu Ser Phe Ser Asp Val Glu Met Gly Glu Ile Ile Met 
            180                 185                 190         


Gly Asn Ile Glu Leu Thr Arg Tyr Thr Arg Pro Thr Pro Val Gln Lys 
        195                 200                 205             


His Ala Ile Pro Ile Ile Lys Glu Lys Arg Asp Leu Met Ala Cys Ala 
    210                 215                 220                 


Gln Thr Gly Ser Gly Lys Thr Ala Ala Phe Leu Leu Pro Ile Leu Ser 
225                 230                 235                 240 


Gln Ile Tyr Ser Asp Gly Pro Gly Glu Ala Leu Arg Ala Met Lys Glu 
                245                 250                 255     


Asn Gly Arg Tyr Gly Arg Arg Lys Gln Tyr Pro Ile Ser Leu Val Leu 
            260                 265                 270         


Ala Pro Thr Arg Glu Leu Ala Val Gln Ile Tyr Glu Glu Ala Arg Lys 
        275                 280                 285             


Phe Ser Tyr Arg Ser Arg Val Arg Pro Cys Val Val Tyr Gly Gly Ala 
    290                 295                 300                 


Asp Ile Gly Gln Gln Ile Arg Asp Leu Glu Arg Gly Cys His Leu Leu 
305                 310                 315                 320 


Val Ala Thr Pro Gly Arg Leu Val Asp Met Met Glu Arg Gly Lys Ile 
                325                 330                 335     


Gly Leu Asp Phe Cys Lys Tyr Leu Val Leu Asp Glu Ala Asp Arg Met 
            340                 345                 350         


Leu Asp Met Gly Phe Glu Pro Gln Ile Arg Arg Ile Val Glu Gln Asp 
        355                 360                 365             


Thr Met Pro Pro Lys Gly Val Arg His Thr Met Met Phe Ser Ala Thr 
    370                 375                 380                 


Phe Pro Lys Glu Ile Gln Met Leu Ala Arg Asp Phe Leu Asp Glu Tyr 
385                 390                 395                 400 


Ile Phe Leu Ala Val Gly Arg Val Gly Ser Thr Ser Glu Asn Ile Thr 
                405                 410                 415     


Gln Lys Val Val Trp Val Glu Glu Ser Asp Lys Arg Ser Phe Leu Leu 
            420                 425                 430         


Asp Leu Leu Asn Ala Thr Gly Lys Asp Ser Leu Thr Leu Val Phe Val 
        435                 440                 445             


Glu Thr Lys Lys Gly Ala Asp Ser Leu Glu Asp Phe Leu Tyr His Glu 
    450                 455                 460                 


Gly Tyr Ala Cys Thr Ser Ile His Gly Asp Arg Ser Gln Arg Asp Arg 
465                 470                 475                 480 


Glu Glu Ala Leu His Gln Phe Arg Ser Gly Lys Ser Pro Ile Leu Val 
                485                 490                 495     


Ala Thr Ala Val Ala Ala Arg Gly Leu Asp Ile Ser Asn Val Lys His 
            500                 505                 510         


Val Ile Asn Phe Asp Leu Pro Ser Asp Ile Glu Glu Tyr Val His Arg 
        515                 520                 525             


Ile Gly Arg Thr Gly Arg Val Gly Asn Leu Gly Leu Ala Thr Ser Phe 
    530                 535                 540                 


Phe Asn Glu Arg Asn Ile Asn Ile Thr Lys Asp Leu Leu Asp Leu Leu 
545                 550                 555                 560 


Val Glu Ala Lys Gln Glu Val Pro Ser Trp Leu Glu Asn Met Ala Tyr 
                565                 570                 575     


Glu His His Tyr Lys Gly Ser Ser Arg Gly Arg Ser Lys Ser Ser Arg 
            580                 585                 590         


Phe Ser Gly Gly Phe Gly Ala Arg Asp Tyr Arg Gln Ser Ser Gly Ala 
        595                 600                 605             


Ser Ser Ser Ser Phe Ser Ser Ser Arg Ala Ser Ser Ser Arg Ser Gly 
    610                 615                 620                 


Gly Gly Gly His Gly Ser Ser Arg Gly Phe Gly Gly Gly Gly Tyr Gly 
625                 630                 635                 640 


Gly Phe Tyr Asn Ser Asp Gly Tyr Gly Gly Asn Tyr Asn Ser Gln Gly 
                645                 650                 655     


Val Asp Trp Trp Gly Asn 
            660         


<210>  10
<211>  661
<212>  PRT
<213>  Mus musculus

<400>  10

Met Ser His Val Ala Val Glu Asn Ala Leu Gly Leu Asp Gln Gln Phe 
1               5                   10                  15      


Ala Gly Leu Asp Leu Asn Ser Ser Asp Asn Gln Ser Gly Gly Ser Thr 
            20                  25                  30          


Ala Ser Lys Gly Arg Tyr Ile Pro Pro His Leu Arg Asn Arg Glu Ala 
        35                  40                  45              


Thr Lys Gly Phe Tyr Asp Lys Asp Ser Ser Gly Trp Ser Ser Ser Lys 
    50                  55                  60                  


Asp Lys Asp Ala Tyr Ser Ser Phe Gly Ser Arg Gly Asp Ser Arg Gly 
65                  70                  75                  80  


Lys Ser Ser Phe Phe Gly Asp Arg Gly Ser Gly Ser Arg Gly Arg Phe 
                85                  90                  95      


Asp Asp Arg Gly Arg Gly Asp Tyr Asp Gly Ile Gly Gly Arg Gly Asp 
            100                 105                 110         


Arg Ser Gly Phe Gly Lys Phe Glu Arg Gly Gly Asn Ser Arg Trp Cys 
        115                 120                 125             


Asp Lys Ser Asp Glu Asp Asp Trp Ser Lys Pro Leu Pro Pro Ser Glu 
    130                 135                 140                 


Arg Leu Glu Gln Glu Leu Phe Ser Gly Gly Asn Thr Gly Ile Asn Phe 
145                 150                 155                 160 


Glu Lys Tyr Asp Asp Ile Pro Val Glu Ala Thr Gly Asn Asn Cys Pro 
                165                 170                 175     


Pro His Ile Glu Ser Phe Ser Asp Val Glu Met Gly Glu Ile Ile Met 
            180                 185                 190         


Gly Asn Ile Glu Leu Thr Arg Tyr Thr Arg Pro Thr Pro Val Gln Lys 
        195                 200                 205             


His Ala Ile Pro Ile Ile Lys Glu Lys Arg Asp Leu Met Ala Cys Ala 
    210                 215                 220                 


Gln Thr Gly Ser Gly Lys Thr Ala Ala Phe Leu Leu Pro Ile Leu Ser 
225                 230                 235                 240 


Gln Ile Tyr Ala Asp Gly Pro Gly Glu Ala Leu Arg Ala Met Lys Glu 
                245                 250                 255     


Asn Gly Arg Tyr Gly Arg Arg Lys Gln Tyr Pro Ile Ser Leu Val Leu 
            260                 265                 270         


Ala Pro Thr Arg Glu Leu Ala Val Gln Ile Tyr Glu Glu Ala Arg Lys 
        275                 280                 285             


Phe Ser Tyr Arg Ser Arg Val Arg Pro Cys Val Val Tyr Gly Gly Ala 
    290                 295                 300                 


Glu Ile Gly Gln Gln Ile Arg Asp Leu Glu Arg Gly Cys His Leu Leu 
305                 310                 315                 320 


Val Ala Thr Pro Gly Arg Leu Val Asp Met Met Glu Arg Gly Lys Ile 
                325                 330                 335     


Gly Leu Asp Phe Cys Lys Tyr Leu Val Leu Asp Glu Ala Asp Arg Met 
            340                 345                 350         


Leu Asp Met Gly Phe Glu Pro Gln Ile Arg Arg Ile Val Glu Gln Asp 
        355                 360                 365             


Thr Met Pro Pro Lys Gly Val Arg His Thr Met Met Phe Ser Ala Thr 
    370                 375                 380                 


Phe Pro Lys Glu Ile Gln Met Leu Ala Arg Asp Phe Leu Asp Glu Tyr 
385                 390                 395                 400 


Ile Phe Leu Ala Val Gly Arg Val Gly Ser Thr Ser Glu Asn Ile Thr 
                405                 410                 415     


Gln Lys Val Val Trp Val Glu Glu Ile Asp Lys Arg Ser Phe Leu Leu 
            420                 425                 430         


Asp Leu Leu Asn Ala Thr Gly Lys Asp Ser Leu Thr Leu Val Phe Val 
        435                 440                 445             


Glu Thr Lys Lys Gly Ala Asp Ser Leu Glu Asp Phe Leu Tyr His Glu 
    450                 455                 460                 


Gly Tyr Ala Cys Thr Ser Ile His Gly Asp Arg Ser Gln Arg Asp Arg 
465                 470                 475                 480 


Glu Glu Ala Leu His Gln Phe Arg Ser Gly Lys Ser Pro Ile Leu Val 
                485                 490                 495     


Ala Thr Ala Val Ala Ala Arg Gly Leu Asp Ile Ser Asn Val Lys His 
            500                 505                 510         


Val Ile Asn Phe Asp Leu Pro Ser Asp Ile Glu Glu Tyr Val His Arg 
        515                 520                 525             


Ile Gly Arg Thr Gly Arg Val Gly Asn Leu Gly Leu Ala Thr Ser Phe 
    530                 535                 540                 


Phe Asn Glu Arg Asn Ile Asn Ile Thr Lys Asp Leu Leu Asp Leu Leu 
545                 550                 555                 560 


Val Glu Ala Lys Gln Glu Val Pro Ser Trp Leu Glu Asn Met Ala Phe 
                565                 570                 575     


Glu His His Tyr Lys Gly Ser Ser Arg Gly Arg Ser Lys Ser Arg Phe 
            580                 585                 590         


Ser Gly Gly Phe Gly Ala Arg Asp Tyr Arg Gln Ser Ser Gly Ala Ser 
        595                 600                 605             


Ser Ser Ser Phe Ser Ser Ser Arg Ala Ser Ser Ser Arg Ser Gly Gly 
    610                 615                 620                 


Gly Gly His Gly Gly Ser Arg Gly Phe Gly Gly Gly Gly Tyr Gly Gly 
625                 630                 635                 640 


Phe Tyr Asn Ser Asp Gly Tyr Gly Gly Asn Tyr Asn Ser Gln Gly Val 
                645                 650                 655     


Asp Trp Trp Gly Asn 
            660     


<210>  11
<211>  661
<212>  PRT
<213>  Ovis aries

<400>  11

Met Ser His Val Ala Val Glu Asn Ala Leu Gly Leu Asp Gln Gln Phe 
1               5                   10                  15      


Ala Gly Leu Asp Leu Asn Ser Ser Asp Asn Gln Ser Gly Gly Ser Thr 
            20                  25                  30          


Ala Ser Lys Gly Arg Tyr Ile Pro Pro His Leu Arg Asn Arg Glu Ala 
        35                  40                  45              


Thr Lys Gly Phe Tyr Asp Lys Asp Ser Ser Gly Trp Ser Ser Ser Lys 
    50                  55                  60                  


Asp Lys Asp Ala Tyr Ser Ser Phe Gly Ser Arg Ser Asp Ser Arg Gly 
65                  70                  75                  80  


Lys Ser Ser Phe Phe Ser Asp Arg Gly Ser Gly Ser Arg Gly Arg Phe 
                85                  90                  95      


Asp Asp Arg Gly Arg Gly Asp Tyr Asp Gly Ile Gly Gly Arg Gly Asp 
            100                 105                 110         


Arg Gly Gly Phe Gly Lys Tyr Glu Arg Gly Asn Ser Arg Trp Cys Asp 
        115                 120                 125             


Lys Ser Asp Glu Asp Asp Trp Ser Lys Pro Leu Pro Pro Ser Glu Arg 
    130                 135                 140                 


Leu Glu Gln Glu Leu Phe Ser Gly Gly Asn Thr Gly Ile Asn Phe Glu 
145                 150                 155                 160 


Lys Tyr Asp Asp Ile Pro Val Glu Ala Thr Gly Asn Asn Cys Pro Pro 
                165                 170                 175     


His Ile Glu Ser Phe Ser Asp Val Glu Met Gly Glu Ile Ile Met Gly 
            180                 185                 190         


Asn Ile Glu Leu Thr Arg Tyr Thr Arg Pro Thr Pro Val Gln Lys His 
        195                 200                 205             


Ala Ile Pro Ile Ile Lys Glu Lys Arg Asp Leu Met Ala Cys Ala Gln 
    210                 215                 220                 


Thr Gly Ser Gly Lys Thr Ala Ala Phe Leu Leu Pro Ile Leu Ser Gln 
225                 230                 235                 240 


Ile Tyr Ser Asp Gly Pro Gly Glu Ala Leu Arg Ala Met Lys Glu Asn 
                245                 250                 255     


Gly Arg Tyr Gly Arg Arg Lys Gln Tyr Pro Ile Ser Leu Val Leu Ala 
            260                 265                 270         


Pro Thr Arg Glu Leu Ala Val Gln Ile Tyr Glu Glu Ala Arg Lys Phe 
        275                 280                 285             


Ser Tyr Arg Ser Arg Val Arg Pro Cys Val Val Tyr Gly Gly Ala Asp 
    290                 295                 300                 


Ile Gly Gln Gln Ile Arg Asp Leu Glu Arg Gly Cys His Leu Leu Val 
305                 310                 315                 320 


Ala Thr Pro Gly Arg Leu Val Asp Met Met Glu Arg Gly Lys Ile Gly 
                325                 330                 335     


Leu Asp Phe Cys Lys Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu 
            340                 345                 350         


Asp Met Gly Phe Glu Pro Gln Ile Arg Arg Ile Val Glu Gln Asp Thr 
        355                 360                 365             


Met Pro Pro Lys Gly Val Arg His Thr Met Met Phe Ser Ala Thr Phe 
    370                 375                 380                 


Pro Lys Glu Ile Gln Met Leu Ala Arg Asp Phe Leu Asp Glu Tyr Ile 
385                 390                 395                 400 


Phe Leu Ala Val Gly Arg Val Gly Ser Thr Ser Glu Asn Ile Thr Gln 
                405                 410                 415     


Lys Val Val Trp Val Glu Glu Ser Asp Lys Arg Ser Phe Leu Leu Asp 
            420                 425                 430         


Leu Leu Asn Ala Thr Gly Lys Asp Ser Leu Thr Leu Val Phe Val Glu 
        435                 440                 445             


Thr Lys Lys Gly Ala Asp Ser Leu Glu Asp Phe Leu Tyr His Glu Gly 
    450                 455                 460                 


Tyr Ala Cys Thr Ser Ile His Gly Asp Arg Ser Gln Arg Asp Arg Glu 
465                 470                 475                 480 


Glu Ala Leu His Gln Phe Arg Ser Gly Lys Ser Pro Ile Leu Val Ala 
                485                 490                 495     


Thr Ala Val Ala Ala Arg Gly Leu Asp Ile Ser Asn Val Lys His Val 
            500                 505                 510         


Ile Asn Phe Asp Leu Pro Ser Asp Ile Glu Glu Tyr Val His Arg Ile 
        515                 520                 525             


Gly Arg Thr Gly Arg Val Gly Asn Leu Gly Leu Ala Thr Ser Phe Phe 
    530                 535                 540                 


Asn Glu Arg Asn Ile Asn Ile Thr Lys Asp Leu Leu Asp Leu Leu Val 
545                 550                 555                 560 


Glu Ala Lys Gln Glu Val Pro Ser Trp Leu Glu Asn Met Ala Tyr Glu 
                565                 570                 575     


His His Tyr Lys Gly Ser Ser Arg Gly Arg Ser Lys Ser Ser Arg Phe 
            580                 585                 590         


Ser Gly Gly Phe Gly Ala Arg Asp Tyr Arg Gln Ser Ser Gly Gly Ser 
        595                 600                 605             


Ser Ser Ser Phe Ser Ser Ser Arg Ala Ser Ser Ser Arg Ser Gly Gly 
    610                 615                 620                 


Gly Gly His Gly Ser Ser Arg Gly Phe Gly Gly Gly Gly Tyr Gly Gly 
625                 630                 635                 640 


Phe Tyr Asn Ser Asp Gly Tyr Gly Gly Asn Tyr Asn Ser Gln Gly Val 
                645                 650                 655     


Asp Trp Trp Gly Asn 
            660     


<210>  12
<211>  660
<212>  PRT
<213>  Bos taurus

<400>  12

Met Ser His Val Ala Val Glu Asn Ala Leu Gly Leu Asp Gln Gln Phe 
1               5                   10                  15      


Ala Gly Leu Asp Leu Asn Ser Ser Asp Asn Gln Ser Gly Gly Ser Thr 
            20                  25                  30          


Ala Ser Lys Gly Arg Tyr Ile Pro Pro His Leu Arg Asn Arg Glu Ala 
        35                  40                  45              


Thr Lys Gly Phe Tyr Asp Lys Asp Ser Ser Gly Trp Ser Ser Ser Lys 
    50                  55                  60                  


Asp Lys Asp Ala Tyr Ser Ser Phe Gly Ser Arg Ser Asp Ser Arg Gly 
65                  70                  75                  80  


Lys Ser Ser Phe Phe Ser Asp Arg Gly Ser Gly Ser Arg Gly Arg Phe 
                85                  90                  95      


Asp Asp Arg Gly Arg Gly Asp Tyr Asp Gly Ile Gly Gly Arg Gly Asp 
            100                 105                 110         


Arg Gly Gly Phe Gly Lys Tyr Glu Arg Gly Asn Ser Arg Trp Cys Asp 
        115                 120                 125             


Lys Ser Asp Glu Asp Asp Trp Ser Lys Pro Leu Pro Pro Ser Glu Arg 
    130                 135                 140                 


Leu Glu Gln Glu Leu Phe Ser Gly Gly Asn Thr Gly Ile Asn Phe Glu 
145                 150                 155                 160 


Lys Tyr Asp Asp Ile Pro Val Glu Ala Thr Gly Asn Asn Cys Pro Pro 
                165                 170                 175     


His Ile Glu Ser Phe Ser Asp Val Glu Met Gly Glu Ile Ile Met Gly 
            180                 185                 190         


Asn Ile Glu Leu Thr Arg Tyr Thr Arg Pro Thr Pro Val Gln Lys His 
        195                 200                 205             


Ala Ile Pro Ile Ile Lys Glu Lys Arg Asp Leu Met Ala Cys Ala Gln 
    210                 215                 220                 


Thr Gly Ser Gly Lys Thr Ala Ala Phe Leu Leu Pro Ile Leu Ser Gln 
225                 230                 235                 240 


Ile Tyr Ser Asp Gly Pro Gly Glu Ala Leu Arg Ala Met Lys Glu Asn 
                245                 250                 255     


Gly Arg Tyr Gly Arg Arg Lys Gln Tyr Pro Ile Ser Leu Val Leu Ala 
            260                 265                 270         


Pro Thr Arg Glu Leu Ala Val Gln Ile Tyr Glu Glu Ala Arg Lys Phe 
        275                 280                 285             


Ser Tyr Arg Ser Arg Val Arg Pro Cys Val Val Tyr Gly Gly Ala Asp 
    290                 295                 300                 


Ile Gly Gln Gln Ile Arg Asp Leu Glu Arg Gly Cys His Leu Leu Val 
305                 310                 315                 320 


Ala Thr Pro Gly Arg Leu Val Asp Met Met Glu Arg Gly Lys Ile Gly 
                325                 330                 335     


Leu Asp Phe Cys Lys Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu 
            340                 345                 350         


Asp Met Gly Phe Glu Pro Gln Ile Arg Arg Ile Val Glu Gln Asp Thr 
        355                 360                 365             


Met Pro Pro Lys Gly Val Arg His Thr Met Met Phe Ser Ala Thr Phe 
    370                 375                 380                 


Pro Lys Glu Ile Gln Met Leu Ala Arg Asp Phe Leu Asp Glu Tyr Ile 
385                 390                 395                 400 


Phe Leu Ala Val Gly Arg Val Gly Ser Thr Ser Glu Asn Ile Thr Gln 
                405                 410                 415     


Lys Val Val Trp Val Glu Glu Ser Asp Lys Arg Ser Phe Leu Leu Asp 
            420                 425                 430         


Leu Leu Asn Ala Thr Gly Lys Asp Ser Leu Thr Leu Val Phe Val Glu 
        435                 440                 445             


Thr Lys Lys Gly Ala Asp Ser Leu Glu Asp Phe Leu Tyr His Glu Gly 
    450                 455                 460                 


Tyr Ala Cys Thr Ser Ile His Gly Asp Arg Ser Gln Arg Asp Arg Glu 
465                 470                 475                 480 


Glu Ala Leu His Gln Phe Arg Ser Gly Lys Ser Pro Ile Leu Val Ala 
                485                 490                 495     


Thr Ala Val Ala Ala Arg Gly Leu Asp Ile Ser Asn Val Lys His Val 
            500                 505                 510         


Ile Asn Phe Asp Leu Pro Ser Asp Ile Glu Glu Tyr Val His Arg Ile 
        515                 520                 525             


Gly Arg Thr Gly Arg Val Gly Asn Leu Gly Leu Ala Thr Ser Phe Phe 
    530                 535                 540                 


Asn Glu Arg Asn Ile Asn Ile Thr Lys Asp Leu Leu Asp Leu Leu Val 
545                 550                 555                 560 


Glu Ala Lys Gln Glu Val Pro Ser Trp Leu Glu Asn Met Ala Tyr Glu 
                565                 570                 575     


His His Tyr Lys Gly Ser Ser Arg Gly Arg Ser Lys Ser Arg Phe Ser 
            580                 585                 590         


Gly Gly Phe Gly Ala Arg Asp Tyr Arg Gln Ser Ser Gly Gly Ser Ser 
        595                 600                 605             


Ser Ser Phe Ser Ser Ser Arg Ala Ser Ser Ser Arg Ser Gly Gly Gly 
    610                 615                 620                 


Gly His Gly Ser Ser Arg Gly Phe Gly Gly Gly Gly Tyr Gly Ser Phe 
625                 630                 635                 640 


Tyr Asn Ser Asp Gly Tyr Gly Gly Asn Tyr Asn Ser Gln Gly Val Asp 
                645                 650                 655     


Trp Trp Gly Asn 
            660 


<210>  13
<211>  660
<212>  PRT
<213>  Capra hircus

<400>  13

Met Ser His Val Ala Val Glu Asn Ala Leu Gly Leu Asp Gln Gln Phe 
1               5                   10                  15      


Ala Gly Leu Asp Leu Asn Ser Ser Asp Asn Gln Ser Gly Gly Ser Thr 
            20                  25                  30          


Ala Ser Lys Gly Arg Tyr Ile Pro Pro His Leu Arg Asn Arg Glu Ala 
        35                  40                  45              


Thr Lys Gly Phe Tyr Asp Lys Asp Ser Ser Gly Trp Ser Ser Ser Lys 
    50                  55                  60                  


Asp Lys Asp Ala Tyr Ser Ser Phe Gly Ser Arg Ser Asp Ser Arg Gly 
65                  70                  75                  80  


Lys Ser Ser Phe Phe Ser Asp Arg Gly Ser Gly Ser Arg Gly Arg Phe 
                85                  90                  95      


Asp Asp Arg Gly Arg Gly Asp Tyr Asp Gly Ile Gly Gly Arg Gly Asp 
            100                 105                 110         


Arg Gly Gly Phe Gly Lys Tyr Glu Arg Gly Asn Ser Arg Trp Cys Asp 
        115                 120                 125             


Lys Ser Asp Glu Asp Asp Trp Ser Lys Pro Leu Pro Pro Ser Glu Arg 
    130                 135                 140                 


Leu Glu Gln Glu Leu Phe Ser Gly Gly Asn Thr Gly Ile Asn Phe Glu 
145                 150                 155                 160 


Lys Tyr Asp Asp Ile Pro Val Glu Ala Thr Gly Asn Asn Cys Pro Pro 
                165                 170                 175     


His Ile Glu Ser Phe Ser Asp Val Glu Met Gly Glu Ile Ile Met Gly 
            180                 185                 190         


Asn Ile Glu Leu Thr Arg Tyr Thr Arg Pro Thr Pro Val Gln Lys His 
        195                 200                 205             


Ala Ile Pro Ile Ile Lys Glu Lys Arg Asp Leu Met Ala Cys Ala Gln 
    210                 215                 220                 


Thr Gly Ser Gly Lys Thr Ala Ala Phe Leu Leu Pro Ile Leu Ser Gln 
225                 230                 235                 240 


Ile Tyr Ser Asp Gly Pro Gly Glu Ala Leu Arg Ala Met Lys Glu Asn 
                245                 250                 255     


Gly Arg Tyr Gly Arg Arg Lys Gln Tyr Pro Ile Ser Leu Val Leu Ala 
            260                 265                 270         


Pro Thr Arg Glu Leu Ala Val Gln Ile Tyr Glu Glu Ala Arg Lys Phe 
        275                 280                 285             


Ser Tyr Arg Ser Arg Val Arg Pro Cys Val Val Tyr Gly Gly Ala Asp 
    290                 295                 300                 


Ile Gly Gln Gln Ile Arg Asp Leu Glu Arg Gly Cys His Leu Leu Val 
305                 310                 315                 320 


Ala Thr Pro Gly Arg Leu Val Asp Met Met Glu Arg Gly Lys Ile Gly 
                325                 330                 335     


Leu Asp Phe Cys Lys Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu 
            340                 345                 350         


Asp Met Gly Phe Glu Pro Gln Ile Arg Arg Ile Val Glu Gln Asp Thr 
        355                 360                 365             


Met Pro Pro Lys Gly Val Arg His Thr Met Met Phe Ser Ala Thr Phe 
    370                 375                 380                 


Pro Lys Glu Ile Gln Met Leu Ala Arg Asp Phe Leu Asp Glu Tyr Ile 
385                 390                 395                 400 


Phe Leu Ala Val Gly Arg Val Gly Ser Thr Ser Glu Asn Ile Thr Gln 
                405                 410                 415     


Lys Val Val Trp Val Glu Glu Ser Asp Lys Arg Ser Phe Leu Leu Asp 
            420                 425                 430         


Leu Leu Asn Ala Thr Gly Lys Asp Ser Leu Thr Leu Val Phe Val Glu 
        435                 440                 445             


Thr Lys Lys Gly Ala Asp Ser Leu Glu Asp Phe Leu Tyr His Glu Gly 
    450                 455                 460                 


Tyr Ala Cys Thr Ser Ile His Gly Asp Arg Ser Gln Arg Asp Arg Glu 
465                 470                 475                 480 


Glu Ala Leu His Gln Phe Arg Ser Gly Lys Ser Pro Ile Leu Val Ala 
                485                 490                 495     


Thr Ala Val Ala Ala Arg Gly Leu Asp Ile Ser Asn Val Lys His Val 
            500                 505                 510         


Ile Asn Phe Asp Leu Pro Ser Asp Ile Glu Glu Tyr Val His Arg Ile 
        515                 520                 525             


Gly Arg Thr Gly Arg Val Gly Asn Leu Gly Leu Ala Thr Ser Phe Phe 
    530                 535                 540                 


Asn Glu Arg Asn Ile Asn Ile Thr Lys Asp Leu Leu Asp Leu Leu Val 
545                 550                 555                 560 


Glu Ala Lys Gln Glu Val Pro Ser Trp Leu Glu Asn Met Ala Tyr Glu 
                565                 570                 575     


His His Tyr Lys Gly Ser Ser Arg Gly Arg Ser Lys Ser Arg Phe Ser 
            580                 585                 590         


Gly Gly Phe Gly Ala Arg Asp Tyr Arg Gln Ser Ser Gly Gly Ser Ser 
        595                 600                 605             


Ser Ser Phe Ser Ser Ser Arg Ala Ser Ser Ser Arg Ser Gly Gly Gly 
    610                 615                 620                 


Gly His Gly Ser Ser Arg Gly Phe Gly Gly Gly Gly Tyr Gly Gly Phe 
625                 630                 635                 640 


Tyr Asn Ser Asp Gly Tyr Gly Gly Asn Tyr Asn Ser Gln Gly Val Asp 
                645                 650                 655     


Trp Trp Gly Asn 
            660 


