                         SEQUENCE LISTING

<110>  SANOFI PASTEUR, LTD
 
<120>  Immunogenic Compositions

<130>  APL-14-01-PR

<140>  PCT/IB2015/000985
<141>  2015-03-15

<150>  61/950,414
<151>  2014-03-10

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  838
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  1

Met Lys Ile Asn Lys Lys Tyr Leu Ala Gly Ser Val Ala Val Leu Ala 
1               5                   10                  15      

Leu Ser Val Cys Ser Tyr Glu Leu Gly Arg His Gln Ala Gly Gln Val 
            20                  25                  30          

Lys Lys Glu Ser Asn Arg Val Ser Tyr Ile Asp Gly Asp Gln Ala Gly 
        35                  40                  45              

Gln Lys Ala Glu Asn Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly 
    50                  55                  60                  

Ile Asn Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 
65                  70                  75                  80  

Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 
                85                  90                  95      

Asp Ala Ile Ile Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 
            100                 105                 110         

Leu Lys Asp Ser Asp Ile Val Asn Glu Ile Lys Gly Gly Tyr Val Ile 
        115                 120                 125             

Lys Val Asp Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 
    130                 135                 140                 

Asp Asn Ile Arg Thr Lys Glu Glu Ile Lys Arg Gln Lys Gln Glu His 
145                 150                 155                 160 

Ser His Asn His Asn Ser Arg Ala Asp Asn Ala Val Ala Ala Ala Arg 
                165                 170                 175     

Ala Gln Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala Ser 
            180                 185                 190         

Asp Ile Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly Asp 
        195                 200                 205             

His Tyr His Tyr Ile Pro Lys Asn Glu Leu Ser Ala Ser Glu Leu Ala 
    210                 215                 220                 

Ala Ala Glu Ala Tyr Trp Asn Gly Lys Gln Gly Ser Arg Pro Ser Ser 
225                 230                 235                 240 

Ser Ser Ser Tyr Asn Ala Asn Pro Val Gln Pro Arg Leu Ser Glu Asn 
                245                 250                 255     

His Asn Leu Thr Val Thr Pro Thr Tyr His Gln Asn Gln Gly Glu Asn 
            260                 265                 270         

Ile Ser Ser Leu Leu Arg Glu Leu Tyr Ala Lys Pro Leu Ser Glu Arg 
        275                 280                 285             

His Val Glu Ser Asp Gly Leu Ile Phe Asp Pro Ala Gln Ile Thr Ser 
    290                 295                 300                 

Arg Thr Ala Arg Gly Val Ala Val Pro His Gly Asn His Tyr His Phe 
305                 310                 315                 320 

Ile Pro Tyr Glu Gln Met Ser Glu Leu Glu Lys Arg Ile Ala Arg Ile 
                325                 330                 335     

Ile Pro Leu Arg Tyr Arg Ser Asn His Trp Val Pro Asp Ser Arg Pro 
            340                 345                 350         

Glu Gln Pro Ser Pro Gln Ser Thr Pro Glu Pro Ser Pro Ser Leu Gln 
        355                 360                 365             

Pro Ala Pro Asn Pro Gln Pro Ala Pro Ser Asn Pro Ile Asp Glu Lys 
    370                 375                 380                 

Leu Val Lys Glu Ala Val Arg Lys Val Gly Asp Gly Tyr Val Phe Glu 
385                 390                 395                 400 

Glu Asn Gly Val Ser Arg Tyr Ile Pro Ala Lys Asp Leu Ser Ala Glu 
                405                 410                 415     

Thr Ala Ala Gly Ile Asp Ser Lys Leu Ala Lys Gln Glu Ser Leu Ser 
            420                 425                 430         

His Lys Leu Gly Ala Lys Lys Thr Asp Leu Pro Ser Ser Asp Arg Glu 
        435                 440                 445             

Phe Tyr Asn Lys Ala Tyr Asp Leu Leu Ala Arg Ile His Gln Asp Leu 
    450                 455                 460                 

Leu Asp Asn Lys Gly Arg Gln Val Asp Phe Glu Val Leu Asp Asn Leu 
465                 470                 475                 480 

Leu Glu Arg Leu Lys Asp Val Ser Ser Asp Lys Val Lys Leu Val Asp 
                485                 490                 495     

Asp Ile Leu Ala Phe Leu Ala Pro Ile Arg His Pro Glu Arg Leu Gly 
            500                 505                 510         

Lys Pro Asn Ala Gln Ile Thr Tyr Thr Asp Asp Glu Ile Gln Val Ala 
        515                 520                 525             

Lys Leu Ala Gly Lys Tyr Thr Thr Glu Asp Gly Tyr Ile Phe Asp Pro 
    530                 535                 540                 

Arg Asp Ile Thr Ser Asp Glu Gly Asp Ala Tyr Val Thr Pro His Met 
545                 550                 555                 560 

Thr His Ser His Trp Ile Lys Lys Asp Ser Leu Ser Glu Ala Glu Arg 
                565                 570                 575     

Ala Ala Ala Gln Ala Tyr Ala Lys Glu Lys Gly Leu Thr Pro Pro Ser 
            580                 585                 590         

Thr Asp His Gln Asp Ser Gly Asn Thr Glu Ala Lys Gly Ala Glu Ala 
        595                 600                 605             

Ile Tyr Asn Arg Val Lys Ala Ala Lys Lys Val Pro Leu Asp Arg Met 
    610                 615                 620                 

Pro Tyr Asn Leu Gln Tyr Thr Val Glu Val Lys Asn Gly Ser Leu Ile 
625                 630                 635                 640 

Ile Pro His Tyr Asp His Tyr His Asn Ile Lys Phe Glu Trp Phe Asp 
                645                 650                 655     

Glu Gly Leu Tyr Glu Ala Pro Lys Gly Tyr Ser Leu Glu Asp Leu Leu 
            660                 665                 670         

Ala Thr Val Lys Tyr Tyr Val Glu His Pro Asn Glu Arg Pro His Ser 
        675                 680                 685             

Asp Asn Gly Phe Gly Asn Ala Ser Asp His Val Arg Lys Asn Lys Ala 
    690                 695                 700                 

Asp Gln Asp Ser Lys Pro Asp Glu Asp Lys Glu His Asp Glu Val Ser 
705                 710                 715                 720 

Glu Pro Thr His Pro Glu Ser Asp Glu Lys Glu Asn His Ala Gly Leu 
                725                 730                 735     

Asn Pro Ser Ala Asp Asn Leu Tyr Lys Pro Ser Thr Asp Thr Glu Glu 
            740                 745                 750         

Thr Glu Glu Glu Ala Glu Asp Thr Thr Asp Glu Ala Glu Ile Pro Gln 
        755                 760                 765             

Val Glu Asn Ser Val Ile Asn Ala Lys Ile Ala Asp Ala Glu Ala Leu 
    770                 775                 780                 

Leu Glu Lys Val Thr Asp Pro Ser Ile Arg Gln Asn Ala Met Glu Thr 
785                 790                 795                 800 

Leu Thr Gly Leu Lys Ser Ser Leu Leu Leu Gly Thr Lys Asp Asn Asn 
                805                 810                 815     

Thr Ile Ser Ala Glu Val Asp Ser Leu Leu Ala Leu Leu Lys Glu Ser 
            820                 825                 830         

Gln Pro Ala Pro Ile Gln 
        835             


<210>  2
<211>  641
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  2

Met Lys Lys Thr Thr Ile Leu Ser Leu Thr Thr Ala Ala Val Ile Leu 
1               5                   10                  15      

Ala Ala Tyr Val Pro Asn Glu Pro Ile Leu Ala Asp Thr Pro Ser Ser 
            20                  25                  30          

Glu Val Ile Lys Glu Thr Lys Val Gly Ser Ile Ile Gln Gln Asn Asn 
        35                  40                  45              

Ile Lys Tyr Lys Val Leu Thr Val Glu Gly Asn Ile Arg Thr Val Gln 
    50                  55                  60                  

Val Gly Asn Gly Val Thr Pro Val Glu Phe Glu Ala Gly Gln Asp Gly 
65                  70                  75                  80  

Lys Pro Phe Thr Ile Pro Thr Lys Ile Thr Val Gly Asp Lys Val Phe 
                85                  90                  95      

Thr Val Thr Glu Val Ala Ser Gln Ala Phe Ser Tyr Tyr Pro Asp Glu 
            100                 105                 110         

Thr Gly Arg Ile Val Tyr Tyr Pro Ser Ser Ile Thr Ile Pro Ser Ser 
        115                 120                 125             

Ile Lys Lys Ile Gln Lys Lys Gly Phe His Gly Ser Lys Ala Lys Thr 
    130                 135                 140                 

Ile Ile Phe Asp Lys Gly Ser Gln Leu Glu Lys Ile Glu Asp Arg Ala 
145                 150                 155                 160 

Phe Asp Phe Ser Glu Leu Glu Glu Ile Glu Leu Pro Ala Ser Leu Glu 
                165                 170                 175     

Tyr Ile Gly Thr Ser Ala Phe Ser Phe Ser Gln Lys Leu Lys Lys Leu 
            180                 185                 190         

Thr Phe Ser Ser Ser Ser Lys Leu Glu Leu Ile Ser His Glu Ala Phe 
        195                 200                 205             

Ala Asn Leu Ser Asn Leu Glu Lys Leu Thr Leu Pro Lys Ser Val Lys 
    210                 215                 220                 

Thr Leu Gly Ser Asn Leu Phe Arg Leu Thr Thr Ser Leu Lys His Val 
225                 230                 235                 240 

Asp Val Glu Glu Gly Asn Glu Ser Phe Ala Ser Val Asp Gly Val Leu 
                245                 250                 255     

Phe Ser Lys Asp Lys Thr Gln Leu Ile Tyr Tyr Pro Ser Gln Lys Asn 
            260                 265                 270         

Asp Glu Ser Tyr Lys Thr Pro Lys Glu Thr Lys Glu Leu Ala Ser Tyr 
        275                 280                 285             

Ser Phe Asn Lys Asn Ser Tyr Leu Lys Lys Leu Glu Leu Asn Glu Gly 
    290                 295                 300                 

Leu Glu Lys Ile Gly Thr Phe Ala Phe Ala Asp Ala Ile Lys Leu Glu 
305                 310                 315                 320 

Glu Ile Ser Leu Pro Asn Ser Leu Glu Thr Ile Glu Arg Leu Ala Phe 
                325                 330                 335     

Tyr Gly Asn Leu Glu Leu Lys Glu Leu Ile Leu Pro Asp Asn Val Lys 
            340                 345                 350         

Asn Phe Gly Lys His Val Met Asn Gly Leu Pro Lys Leu Lys Ser Leu 
        355                 360                 365             

Thr Ile Gly Asn Asn Ile Asn Ser Leu Pro Ser Phe Phe Leu Ser Gly 
    370                 375                 380                 

Val Leu Asp Ser Leu Lys Glu Ile His Ile Lys Asn Lys Ser Thr Glu 
385                 390                 395                 400 

Phe Ser Val Lys Lys Asp Thr Phe Ala Ile Pro Glu Thr Val Lys Phe 
                405                 410                 415     

Tyr Val Thr Ser Glu His Ile Lys Asp Val Leu Lys Ser Asn Leu Ser 
            420                 425                 430         

Thr Ser Asn Asp Ile Ile Val Glu Lys Val Asp Asn Ile Lys Gln Glu 
        435                 440                 445             

Thr Asp Val Ala Lys Pro Lys Lys Asn Ser Asn Gln Gly Val Val Gly 
    450                 455                 460                 

Trp Val Lys Asp Lys Gly Leu Trp Tyr Tyr Leu Asn Glu Ser Gly Ser 
465                 470                 475                 480 

Met Ala Thr Gly Trp Val Lys Asp Lys Gly Leu Trp Tyr Tyr Leu Asn 
                485                 490                 495     

Glu Ser Gly Ser Met Ala Thr Gly Trp Val Lys Asp Lys Gly Leu Trp 
            500                 505                 510         

Tyr Tyr Leu Asn Glu Ser Gly Ser Met Ala Thr Gly Trp Val Lys Asp 
        515                 520                 525             

Lys Gly Leu Trp Tyr Tyr Leu Asn Glu Ser Gly Ser Met Ala Thr Gly 
    530                 535                 540                 

Trp Val Lys Asp Lys Gly Leu Trp Tyr Tyr Leu Asn Glu Ser Gly Ser 
545                 550                 555                 560 

Met Ala Thr Gly Trp Val Lys Asp Lys Gly Leu Trp Tyr Tyr Leu Asn 
                565                 570                 575     

Glu Ser Gly Ser Met Ala Thr Gly Trp Val Lys Asp Lys Gly Leu Trp 
            580                 585                 590         

Tyr Tyr Leu Asn Glu Ser Gly Ser Met Ala Thr Gly Trp Phe Thr Val 
        595                 600                 605             

Ser Gly Lys Trp Tyr Tyr Thr Tyr Asn Ser Gly Asp Leu Leu Val Asn 
    610                 615                 620                 

Thr Thr Thr Pro Asp Gly Tyr Arg Val Asn Ala Asn Gly Glu Trp Val 
625                 630                 635                 640 

Gly 
    


<210>  3
<211>  2514
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  3
atgaaaatca ataaaaaata tctagcaggt tcagtggcag tccttgccct aagtgtttgt       60

tcctatgaac ttggtcgtca ccaagctggt caggttaaga aagagtctaa tcgagtttct      120

tatatagatg gtgatcaggc tggtcaaaag gcagaaaatt tgacaccaga tgaagtcagt      180

aagagagagg ggatcaacgc cgaacaaatt gttatcaaga ttacggatca aggttatgtg      240

acctctcatg gagaccatta tcattactat aatggcaagg ttccttatga tgccatcatc      300

agtgaagaac ttctcatgaa agatccgaat tatcagttga aggattcaga cattgtcaat      360

gaaatcaagg gtggctatgt gattaaggta gacggaaaat actatgttta ccttaaagat      420

gcggcccatg cggacaatat tcggacaaaa gaagagatta aacgtcagaa gcaggaacac      480

agtcataatc ataactcaag agcagataat gctgttgctg cagccagagc ccaaggacgt      540

tatacaacgg atgatgggta tatcttcaat gcatctgata tcattgagga cacgggtgat      600

gcttatatcg ttcctcacgg cgaccattac cattacattc ctaagaatga gttatcagct      660

agcgagttag ctgctgcaga agcctattgg aatgggaagc agggatctcg tccttcttca      720

agttctagtt ataatgcaaa tccagttcaa ccaagattgt cagagaacca caatctgact      780

gtcactccaa cttatcatca aaatcaaggg gaaaacattt caagcctttt acgtgaattg      840

tatgctaaac ccttatcaga acgccatgta gaatctgatg gccttatttt cgacccagcg      900

caaatcacaa gtcgaaccgc cagaggtgta gctgtccctc atggtaacca ttaccacttt      960

atcccttatg aacaaatgtc tgaattggaa aaacgaattg ctcgtattat tccccttcgt     1020

tatcgttcaa accattgggt accagattca agaccagaac aaccaagtcc acaatcgact     1080

ccggaaccta gtccaagtct gcaacctgca ccaaatcctc aaccagctcc aagcaatcca     1140

attgatgaga aattggtcaa agaagctgtt cgaaaagtag gcgatggtta tgtctttgag     1200

gagaatggag tttctcgtta tatcccagcc aaggatcttt cagcagaaac agcagcaggc     1260

attgatagca aactggccaa gcaggaaagt ttatctcata agctaggagc taagaaaact     1320

gacctcccat ctagtgatcg agaattttac aataaggctt atgacttact agcaagaatt     1380

caccaagatt tacttgataa taaaggtcga caagttgatt ttgaggtttt ggataacctg     1440

ttggaacgac tcaaggatgt ctcaagtgat aaagtcaagt tagtggatga tattcttgcc     1500

ttcttagctc cgattcgtca tccagaacgt ttaggaaaac caaatgcgca aattacctac     1560

actgatgatg agattcaagt agccaagttg gcaggcaagt acacaacaga agacggttat     1620

atctttgatc ctcgtgatat aaccagtgat gagggggatg cctatgtaac tccacatatg     1680

acccatagcc actggattaa aaaagatagt ttgtctgaag ctgagagagc ggcagcccag     1740

gcttatgcta aagagaaagg tttgacccct ccttcgacag accatcagga ttcaggaaat     1800

actgaggcaa aaggagcaga agctatctac aaccgcgtga aagcagctaa gaaggtgcca     1860

cttgatcgta tgccttacaa tcttcaatat actgtagaag tcaaaaacgg tagtttaatc     1920

atacctcatt atgaccatta ccataacatc aaatttgagt ggtttgacga aggcctttat     1980

gaggcaccta aggggtatag tcttgaggat cttttggcga ctgtcaagta ctatgtcgaa     2040

catccaaacg aacgtccgca ttcagataat ggttttggta acgctagtga ccatgttcgt     2100

aaaaataagg cagaccaaga tagtaaacct gatgaagata aggaacatga tgaagtaagt     2160

gagccaactc accctgaatc tgatgaaaaa gagaatcacg ctggtttaaa tccttcagca     2220

gataatcttt ataaaccaag cactgatacg gaagagacag aggaagaagc tgaagatacc     2280

acagatgagg ctgaaattcc tcaagtagag aattctgtta ttaacgctaa gatagcagat     2340

gcggaggcct tgctagaaaa agtaacagat cctagtatta gacaaaatgc tatggagaca     2400

ttgactggtc taaaaagtag tcttcttctc ggaacgaaag ataataacac tatttcagca     2460

gaagtagata gtctcttggc tttgttaaaa gaaagtcaac cggctcctat acag           2514


<210>  4
<211>  1923
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  4
atgaaaaaaa ctacaatatt atcattaact acagctgcgg ttattttagc agcatatgtc       60

cctaatgaac caatcctagc agatactcct agttcggaag taatcaaaga gactaaagtt      120

ggaagtatta ttcaacaaaa taatatcaaa tataaggttc taactgtaga aggtaacata      180

agaactgttc aagtgggtaa tggagttact cctgtagagt ttgaagctgg tcaagatgga      240

aaaccattca cgattcctac aaaaatcaca gtaggtgata aagtatttac cgttactgaa      300

gtagctagtc aagcttttag ttattatcca gatgaaacag gtagaattgt ctactatcct      360

agctctatta ctatcccatc aagcataaaa aaaatacaaa aaaaaggctt ccatggaagt      420

aaagctaaaa ctattatttt tgacaaaggc agtcagctgg agaaaattga agatagagct      480

tttgattttt ctgaattaga agagattgaa ttgcctgcat ctctagaata tattggaaca      540

agtgcatttt cttttagtca aaaattgaaa aagctaacct tttcctcaag ttcaaaatta      600

gaattaatat cacatgaggc ttttgctaat ttatcaaatt tagagaaact aacattacca      660

aaatcggtta aaacattagg aagtaatcta tttagactca ctactagctt aaaacatgtt      720

gatgttgaag aaggaaatga atcgtttgcc tcagttgatg gtgttttgtt ttcaaaagat      780

aaaactcaat taatttatta tccaagtcaa aaaaatgacg aaagttataa aacgcctaag      840

gagacaaaag aacttgcatc atattcgttt aataaaaatt cttacttgaa aaaactcgaa      900

ttgaatgaag gtttagaaaa aatcggtact tttgcatttg cggatgcgat taaacttgaa      960

gaaattagct taccaaatag tttagaaact attgaacgtt tagcctttta cggtaattta     1020

gaattaaaag aacttatatt accagataat gttaaaaatt ttggtaaaca cgttatgaac     1080

ggtttaccaa aattaaaaag tttaacaatt ggtaataata tcaactcatt gccgtccttc     1140

ttcctaagtg gcgtcttaga ttcattaaag gaaattcata ttaagaataa aagtacagag     1200

ttttctgtga aaaaagatac atttgcaatt cctgaaactg ttaagttcta tgtaacatca     1260

gaacatataa aagatgttct taaatcaaat ttatctacta gtaatgatat cattgttgaa     1320

aaagtagata atataaaaca agaaactgat gtagctaaac ctaaaaagaa ttctaatcag     1380

ggagtagttg gttgggttaa agacaaaggt ttatggtatt acttaaacga atcaggttca     1440

atggctactg gttgggttaa agacaaaggt ttatggtatt acttaaacga atcaggttca     1500

atggctactg gttgggttaa agacaaaggc ttatggtatt acttaaacga atcaggttca     1560

atggctactg gttgggttaa agacaaaggc ttatggtatt acttaaatga atcaggttca     1620

atggctactg gttgggttaa agacaaaggc ttatggtatt acttaaacga atcaggttca     1680

atggctactg gttgggttaa agacaaaggc ttatggtatt acttaaacga atcaggttca     1740

atggctactg gttgggttaa agacaaaggc ttatggtatt acttaaatga atcaggttca     1800

atggctactg gttggtttac agtttctggt aaatggtact atacctataa ttcaggagat     1860

ttattagtaa acacgactac acccgatggc tatcgagtca atgctaacgg tgagtgggta     1920

gga                                                                   1923


<210>  5
<211>  820
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  5

Met Gly Ser Tyr Glu Leu Gly Arg His Gln Ala Gly Gln Val Lys Lys 
1               5                   10                  15      

Glu Ser Asn Arg Val Ser Tyr Ile Asp Gly Asp Gln Ala Gly Gln Lys 
            20                  25                  30          

Ala Glu Asn Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly Ile Asn 
        35                  40                  45              

Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val Thr Ser 
    50                  55                  60                  

His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr Asp Ala 
65                  70                  75                  80  

Ile Ile Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln Leu Lys 
                85                  90                  95      

Asp Ser Asp Ile Val Asn Glu Ile Lys Gly Gly Tyr Val Ile Lys Val 
            100                 105                 110         

Asp Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala Asp Asn 
        115                 120                 125             

Ile Arg Thr Lys Glu Glu Ile Lys Arg Gln Lys Gln Glu His Ser His 
    130                 135                 140                 

Asn His Asn Ser Arg Ala Asp Asn Ala Val Ala Ala Ala Arg Ala Gln 
145                 150                 155                 160 

Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala Ser Asp Ile 
                165                 170                 175     

Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly Asp His Tyr 
            180                 185                 190         

His Tyr Ile Pro Lys Asn Glu Leu Ser Ala Ser Glu Leu Ala Ala Ala 
        195                 200                 205             

Glu Ala Tyr Trp Asn Gly Lys Gln Gly Ser Arg Pro Ser Ser Ser Ser 
    210                 215                 220                 

Ser Tyr Asn Ala Asn Pro Val Gln Pro Arg Leu Ser Glu Asn His Asn 
225                 230                 235                 240 

Leu Thr Val Thr Pro Thr Tyr His Gln Asn Gln Gly Glu Asn Ile Ser 
                245                 250                 255     

Ser Leu Leu Arg Glu Leu Tyr Ala Lys Pro Leu Ser Glu Arg His Val 
            260                 265                 270         

Glu Ser Asp Gly Leu Ile Phe Asp Pro Ala Gln Ile Thr Ser Arg Thr 
        275                 280                 285             

Ala Arg Gly Val Ala Val Pro His Gly Asn His Tyr His Phe Ile Pro 
    290                 295                 300                 

Tyr Glu Gln Met Ser Glu Leu Glu Lys Arg Ile Ala Arg Ile Ile Pro 
305                 310                 315                 320 

Leu Arg Tyr Arg Ser Asn His Trp Val Pro Asp Ser Arg Pro Glu Gln 
                325                 330                 335     

Pro Ser Pro Gln Ser Thr Pro Glu Pro Ser Pro Ser Leu Gln Pro Ala 
            340                 345                 350         

Pro Asn Pro Gln Pro Ala Pro Ser Asn Pro Ile Asp Glu Lys Leu Val 
        355                 360                 365             

Lys Glu Ala Val Arg Lys Val Gly Asp Gly Tyr Val Phe Glu Glu Asn 
    370                 375                 380                 

Gly Val Ser Arg Tyr Ile Pro Ala Lys Asp Leu Ser Ala Glu Thr Ala 
385                 390                 395                 400 

Ala Gly Ile Asp Ser Lys Leu Ala Lys Gln Glu Ser Leu Ser His Lys 
                405                 410                 415     

Leu Gly Ala Lys Lys Thr Asp Leu Pro Ser Ser Asp Arg Glu Phe Tyr 
            420                 425                 430         

Asn Lys Ala Tyr Asp Leu Leu Ala Arg Ile His Gln Asp Leu Leu Asp 
        435                 440                 445             

Asn Lys Gly Arg Gln Val Asp Phe Glu Val Leu Asp Asn Leu Leu Glu 
    450                 455                 460                 

Arg Leu Lys Asp Val Ser Ser Asp Lys Val Lys Leu Val Asp Asp Ile 
465                 470                 475                 480 

Leu Ala Phe Leu Ala Pro Ile Arg His Pro Glu Arg Leu Gly Lys Pro 
                485                 490                 495     

Asn Ala Gln Ile Thr Tyr Thr Asp Asp Glu Ile Gln Val Ala Lys Leu 
            500                 505                 510         

Ala Gly Lys Tyr Thr Thr Glu Asp Gly Tyr Ile Phe Asp Pro Arg Asp 
        515                 520                 525             

Ile Thr Ser Asp Glu Gly Asp Ala Tyr Val Thr Pro His Met Thr His 
    530                 535                 540                 

Ser His Trp Ile Lys Lys Asp Ser Leu Ser Glu Ala Glu Arg Ala Ala 
545                 550                 555                 560 

Ala Gln Ala Tyr Ala Lys Glu Lys Gly Leu Thr Pro Pro Ser Thr Asp 
                565                 570                 575     

His Gln Asp Ser Gly Asn Thr Glu Ala Lys Gly Ala Glu Ala Ile Tyr 
            580                 585                 590         

Asn Arg Val Lys Ala Ala Lys Lys Val Pro Leu Asp Arg Met Pro Tyr 
        595                 600                 605             

Asn Leu Gln Tyr Thr Val Glu Val Lys Asn Gly Ser Leu Ile Ile Pro 
    610                 615                 620                 

His Tyr Asp His Tyr His Asn Ile Lys Phe Glu Trp Phe Asp Glu Gly 
625                 630                 635                 640 

Leu Tyr Glu Ala Pro Lys Gly Tyr Ser Leu Glu Asp Leu Leu Ala Thr 
                645                 650                 655     

Val Lys Tyr Tyr Val Glu His Pro Asn Glu Arg Pro His Ser Asp Asn 
            660                 665                 670         

Gly Phe Gly Asn Ala Ser Asp His Val Arg Lys Asn Lys Ala Asp Gln 
        675                 680                 685             

Asp Ser Lys Pro Asp Glu Asp Lys Glu His Asp Glu Val Ser Glu Pro 
    690                 695                 700                 

Thr His Pro Glu Ser Asp Glu Lys Glu Asn His Ala Gly Leu Asn Pro 
705                 710                 715                 720 

Ser Ala Asp Asn Leu Tyr Lys Pro Ser Thr Asp Thr Glu Glu Thr Glu 
                725                 730                 735     

Glu Glu Ala Glu Asp Thr Thr Asp Glu Ala Glu Ile Pro Gln Val Glu 
            740                 745                 750         

Asn Ser Val Ile Asn Ala Lys Ile Ala Asp Ala Glu Ala Leu Leu Glu 
        755                 760                 765             

Lys Val Thr Asp Pro Ser Ile Arg Gln Asn Ala Met Glu Thr Leu Thr 
    770                 775                 780                 

Gly Leu Lys Ser Ser Leu Leu Leu Gly Thr Lys Asp Asn Asn Thr Ile 
785                 790                 795                 800 

Ser Ala Glu Val Asp Ser Leu Leu Ala Leu Leu Lys Glu Ser Gln Pro 
                805                 810                 815     

Ala Pro Ile Gln 
            820 


<210>  6
<211>  2463
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  6
atgggatcct atgaacttgg tcgtcaccaa gctggtcagg ttaagaaaga gtctaatcga       60

gtttcttata tagatggtga tcaggctggt caaaaggcag aaaatttgac accagatgaa      120

gtcagtaaga gagaggggat caacgccgaa caaattgtta tcaagattac ggatcaaggt      180

tatgtgacct ctcatggaga ccattatcat tactataatg gcaaggttcc ttatgatgcc      240

atcatcagtg aagaacttct catgaaagat ccgaattatc agttgaagga ttcagacatt      300

gtcaatgaaa tcaagggtgg ctatgtgatt aaggtagacg gaaaatacta tgtttacctt      360

aaagatgcgg cccatgcgga caatattcgg acaaaagaag agattaaacg tcagaagcag      420

gaacacagtc ataatcataa ctcaagagca gataatgctg ttgctgcagc cagagcccaa      480

ggacgttata caacggatga tgggtatatc ttcaatgcat ctgatatcat tgaggacacg      540

ggtgatgctt atatcgttcc tcacggcgac cattaccatt acattcctaa gaatgagtta      600

tcagctagcg agttagctgc tgcagaagcc tattggaatg ggaagcaggg atctcgtcct      660

tcttcaagtt ctagttataa tgcaaatcca gttcaaccaa gattgtcaga gaaccacaat      720

ctgactgtca ctccaactta tcatcaaaat caaggggaaa acatttcaag ccttttacgt      780

gaattgtatg ctaaaccctt atcagaacgc catgtagaat ctgatggcct tattttcgac      840

ccagcgcaaa tcacaagtcg aaccgccaga ggtgtagctg tccctcatgg taaccattac      900

cactttatcc cttatgaaca aatgtctgaa ttggaaaaac gaattgctcg tattattccc      960

cttcgttatc gttcaaacca ttgggtacca gattcaagac cagaacaacc aagtccacaa     1020

tcgactccgg aacctagtcc aagtctgcaa cctgcaccaa atcctcaacc agctccaagc     1080

aatccaattg atgagaaatt ggtcaaagaa gctgttcgaa aagtaggcga tggttatgtc     1140

tttgaggaga atggagtttc tcgttatatc ccagccaagg atctttcagc agaaacagca     1200

gcaggcattg atagcaaact ggccaagcag gaaagtttat ctcataagct aggagctaag     1260

aaaactgacc tcccatctag tgatcgagaa ttttacaata aggcttatga cttactagca     1320

agaattcacc aagatttact tgataataaa ggtcgacaag ttgattttga ggttttggat     1380

aacctgttgg aacgactcaa ggatgtctca agtgataaag tcaagttagt ggatgatatt     1440

cttgccttct tagctccgat tcgtcatcca gaacgtttag gaaaaccaaa tgcgcaaatt     1500

acctacactg atgatgagat tcaagtagcc aagttggcag gcaagtacac aacagaagac     1560

ggttatatct ttgatcctcg tgatataacc agtgatgagg gggatgccta tgtaactcca     1620

catatgaccc atagccactg gattaaaaaa gatagtttgt ctgaagctga gagagcggca     1680

gcccaggctt atgctaaaga gaaaggtttg acccctcctt cgacagacca tcaggattca     1740

ggaaatactg aggcaaaagg agcagaagct atctacaacc gcgtgaaagc agctaagaag     1800

gtgccacttg atcgtatgcc ttacaatctt caatatactg tagaagtcaa aaacggtagt     1860

ttaatcatac ctcattatga ccattaccat aacatcaaat ttgagtggtt tgacgaaggc     1920

ctttatgagg cacctaaggg gtatagtctt gaggatcttt tggcgactgt caagtactat     1980

gtcgaacatc caaacgaacg tccgcattca gataatggtt ttggtaacgc tagtgaccat     2040

gttcgtaaaa ataaggcaga ccaagatagt aaacctgatg aagataagga acatgatgaa     2100

gtaagtgagc caactcaccc tgaatctgat gaaaaagaga atcacgctgg tttaaatcct     2160

tcagcagata atctttataa accaagcact gatacggaag agacagagga agaagctgaa     2220

gataccacag atgaggctga aattcctcaa gtagagaatt ctgttattaa cgctaagata     2280

gcagatgcgg aggccttgct agaaaaagta acagatccta gtattagaca aaatgctatg     2340

gagacattga ctggtctaaa aagtagtctt cttctcggaa cgaaagataa taacactatt     2400

tcagcagaag tagatagtct cttggctttg ttaaaagaaa gtcaaccggc tcctatacag     2460

tag                                                                   2463


<210>  7
<211>  445
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  7

Met Ala Asp Thr Pro Ser Ser Glu Val Ile Lys Glu Thr Lys Val Gly 
1               5                   10                  15      

Ser Ile Ile Gln Gln Asn Asn Ile Lys Tyr Lys Val Leu Thr Val Glu 
            20                  25                  30          

Gly Asn Ile Gly Thr Val Gln Val Gly Asn Gly Val Thr Pro Val Glu 
        35                  40                  45              

Phe Glu Ala Gly Gln Asp Gly Lys Pro Phe Thr Ile Pro Thr Lys Ile 
    50                  55                  60                  

Thr Val Gly Asp Lys Val Phe Thr Val Thr Glu Val Ala Ser Gln Ala 
65                  70                  75                  80  

Phe Ser Tyr Tyr Pro Asp Glu Thr Gly Arg Ile Val Tyr Tyr Pro Ser 
                85                  90                  95      

Ser Ile Thr Ile Pro Ser Ser Ile Lys Lys Ile Gln Lys Lys Gly Phe 
            100                 105                 110         

His Gly Ser Lys Ala Lys Thr Ile Ile Phe Asp Lys Gly Ser Gln Leu 
        115                 120                 125             

Glu Lys Ile Glu Asp Arg Ala Phe Asp Phe Ser Glu Leu Glu Glu Ile 
    130                 135                 140                 

Glu Leu Pro Ala Ser Leu Glu Tyr Ile Gly Thr Ser Ala Phe Ser Phe 
145                 150                 155                 160 

Ser Gln Lys Leu Lys Lys Leu Thr Phe Ser Ser Ser Ser Lys Leu Glu 
                165                 170                 175     

Leu Ile Ser His Glu Ala Phe Ala Asn Leu Ser Asn Leu Glu Lys Leu 
            180                 185                 190         

Thr Leu Pro Lys Ser Val Lys Thr Leu Gly Ser Asn Leu Phe Arg Leu 
        195                 200                 205             

Thr Thr Ser Leu Lys His Val Asp Val Glu Glu Gly Asn Glu Ser Phe 
    210                 215                 220                 

Ala Ser Val Asp Gly Val Leu Phe Ser Lys Asp Lys Thr Gln Leu Ile 
225                 230                 235                 240 

Tyr Tyr Pro Ser Gln Lys Asn Asp Glu Ser Tyr Lys Thr Pro Lys Glu 
                245                 250                 255     

Thr Lys Glu Leu Ala Ser Tyr Ser Phe Asn Lys Asn Ser Tyr Leu Lys 
            260                 265                 270         

Lys Leu Glu Leu Asn Glu Gly Leu Glu Lys Ile Gly Thr Phe Ala Phe 
        275                 280                 285             

Ala Asp Ala Ile Lys Leu Glu Glu Ile Ser Leu Pro Asn Ser Leu Glu 
    290                 295                 300                 

Thr Ile Glu Arg Leu Ala Phe Tyr Gly Asn Leu Glu Leu Lys Glu Leu 
305                 310                 315                 320 

Ile Leu Pro Asp Asn Val Lys Asn Phe Gly Lys His Val Met Asn Gly 
                325                 330                 335     

Leu Pro Lys Leu Lys Ser Leu Thr Ile Gly Asn Asn Ile Asn Ser Leu 
            340                 345                 350         

Pro Ser Phe Phe Leu Ser Gly Val Leu Asp Ser Leu Lys Glu Ile His 
        355                 360                 365             

Ile Lys Asn Lys Ser Thr Glu Phe Ser Val Lys Lys Asp Thr Phe Ala 
    370                 375                 380                 

Ile Pro Glu Thr Val Lys Phe Tyr Val Thr Ser Glu His Ile Lys Asp 
385                 390                 395                 400 

Val Leu Lys Ser Asn Leu Ser Thr Ser Asn Asp Ile Ile Val Glu Lys 
                405                 410                 415     

Val Asp Asn Ile Lys Gln Glu Thr Asp Val Ala Lys Pro Lys Lys Asn 
            420                 425                 430         

Ser Asn Gln Gly Val Val Gly Trp Val Lys Asp Lys Gly 
        435                 440                 445 


<210>  8
<211>  1338
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  8
atggcagata ctcctagttc ggaagtaatc aaagagacta aagttggaag tattattcaa       60

caaaataata tcaaatataa ggttctaact gtagaaggta acataggaac tgttcaagtg      120

ggtaatggag ttactcctgt agagtttgaa gctggtcaag atggaaaacc attcacgatt      180

cctacaaaaa tcacagtagg tgataaagta tttaccgtta ctgaagtagc tagtcaagct      240

tttagttatt atccagatga aacaggtaga attgtctact atcctagctc tattactatc      300

ccatcaagca taaaaaaaat acaaaaaaaa ggcttccatg gaagtaaagc taaaactatt      360

atttttgaca aaggcagtca gctggagaaa attgaagata gagcttttga tttttctgaa      420

ttagaagaga ttgaattgcc tgcatctcta gaatatattg gaacaagtgc attttctttt      480

agtcaaaaat tgaaaaagct aaccttttcc tcaagttcaa aattagaatt aatatcacat      540

gaggcttttg ctaatttatc aaatttagag aaactaacat taccaaaatc ggttaaaaca      600

ttaggaagta atctatttag actcactact agcttaaaac atgttgatgt tgaagaagga      660

aatgaatcgt ttgcctcagt tgatggtgtt ttgttttcaa aagataaaac tcaattaatt      720

tattatccaa gtcaaaaaaa tgacgaaagt tataaaacgc ctaaggagac aaaagaactt      780

gcatcatatt cgtttaataa aaattcttac ttgaaaaaac tcgaattgaa tgaaggttta      840

gaaaaaatcg gtacttttgc atttgcggat gcgattaaac ttgaagaaat tagcttacca      900

aatagtttag aaactattga acgtttagcc ttttacggta atttagaatt aaaagaactt      960

atattaccag ataatgttaa aaattttggt aaacacgtta tgaacggttt accaaaatta     1020

aaaagtttaa caattggtaa taatatcaac tcattgccgt ccttcttcct aagtggcgtc     1080

ttagattcat taaaggaaat tcatattaag aataaaagta cagagttttc tgtgaaaaaa     1140

gatacatttg caattcctga aactgttaag ttctatgtaa catcagaaca tataaaagat     1200

gttcttaaat caaatttatc tactagtaat gatatcattg ttgaaaaagt agataatata     1260

aaacaagaaa ctgatgtagc taaacctaaa aagaattcta atcagggagt agttggttgg     1320

gttaaagaca aaggttaa                                                   1338


<210>  9
<211>  471
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  9

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Cys Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Cys Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asp Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala 
            420                 425                 430         

Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 

Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  10
<211>  471
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  10

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asp Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         

Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 

Glu Asp Lys Val Glu Asn Asp 
465                 470     


