                         SEQUENCE LISTING

<110>  Margulies, Bryan S.
       DeBoyace, Sean
 
<120>  NEUROGENIC REGULATION OF BONE GROWTH AND BONE DEGRADATION

<130>  30914

<150>  61/953,475
<151>  2014-03-14

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  5757
<212>  DNA
<213>  Mus musculus

<400>  1
ggcggccgcg tcgtcactcg ggaggaagag gcggcggcgg tggcggccgg ggccggggct       60

ggggcagcgg cggccgcgcc gggcatggag ctggcaagcc cgcgttgaga caggacgctc      120

ttgctagccg ccagcgagag gctctctgca gtccggcgcg cgggctcccc ggcttgggcc      180

aggcaaactt ttctttctct tttgccatca cttagaggcg cctggtgcgg cgggcgaacc      240

gactccttgg cgcggcgggg ccggggcaag ctggccacag catgatgcgc gctgtgtggg      300

aggcgctggc ggcgctggcg gcggtggcgt gcctggtggg cgcggtgcgc ggcgggcccg      360

ggcttagcat gttcgccggc caggcggcgc agcctgatcc ttgctcggat gagaatggac      420

acccgcgccg ctgcatcccg gactttgtca acgcggcctt cggcaaggac gtgcgcgtgt      480

ccagcacctg cggccggccc ccggcgcgct actgcgtggt gagcgagcgt ggtgaagagc      540

ggctgcgctc ctgtcacctc tgcaactctt cggatcccaa gaaagcgcac ccgcccgcct      600

tcctcaccga cctcaataac ccgcacaacc tgacgtgctg gcagtccgag aactacctgc      660

agttcccgca caacgtgacg ctcactctgt cgctcggcaa gaagtttgag gtgacctatg      720

tgagcctgca attctgctcg ccgcggccag agtccatggc catctacaag tccatggact      780

acgggcgcac gtgggtgccc ttccagttct attccacgca gtgccgcaaa atgtacaacc      840

ggccgcaccg cgcgcctatc accaaacaga acgagcagga ggccgtgtgc accgactcgc      900

acaccgacat gcgcccgctc tctggcgggc tgatcgcttt cagcacgctg gacgggcggc      960

cctcggcgca cgacttcgac aactcgccgg tgctgcagga ctgggtcacg gccaccgaca     1020

tccgcgtggc tttcagccgc ctgcacacgt tcggcgacga gaacgaagac gactcggagc     1080

tggcgcgcga ctcctattac tatgcagtgt ctgacctgca ggttggcggc cgctgcaagt     1140

gcaacggcca cgcggcgcgt tgcgtgcgcg accgagacga cagtctggtg tgtgactgta     1200

ggcacaacac ggccggccct gaatgcgacc gttgcaagcc cttccactac gaccggccct     1260

ggcagcgcgc cacggcccgc gaggccaacg agtgcgtggc ctgcaactgc aacctccatg     1320

ctcggcgctg cagattcaac atggagctct ataagctatc agggcgcaag agcgggggag     1380

tctgtctcaa ctgccgccac aacactgcgg gccgccactg ccactactgc aaggagggct     1440

tctaccgaga catgggcaag cctatcaccc accggaaggc ttgcaaagcc tgtgattgcc     1500

acccagtggg tgctgctggc aagacctgca atcaaaccac tggccaatgt ccctgcaagg     1560

acggcgtgac gggcatcacc tgcaaccgat gtgccaaagg ctaccagcag agccgctccc     1620

ccatcgcccc ttgcatcaag attcctgtgg cgccacccac cactgcagcc agcagcgtgg     1680

aggaaccgga agactgtgac tcctattgca aggcctccaa aggcaagctg aagatgaaca     1740

tgaagaaata ctgcaggaag gactatgctg tccagatcca catcctgaag gccgacaaag     1800

caggggactg gtggaagttc accgtgaaca tcatctccgt gtacaagcag ggcacaagtc     1860

gtattcgccg tggtgaccag agtttgtgga tccgctcacg agacatcgcc tgcaagtgtc     1920

ccaaaatcaa gcccctcaag aagtacttgc tgttgggtaa tgccgaggac tcacctgacc     1980

agagtggcat cgtggcagac aagagcagcc tggtgatcca gtggcgggac acatgggcac     2040

ggcggctgcg caagttccag caacgggaga agaagggcaa gtgcaagaag gcctagcgcg     2100

gaggtggcgc gggctccagg agggcgggca gggcgctggc aaaggctggc agccttggac     2160

ttggccgtca ggggtttttt tgggagggtg ggggcggggc gaagtcgaag tggggcgggg     2220

ccctcagcgg ctccgcccca gccccaccct cacacccctg gctgcgctct tatgcgcatg     2280

gcagaaagca ccctgtattg acaggccagg ccctggagaa atgaggacaa gacatagcta     2340

cctcacggcg ctccttccag aacagagatg cgcttcccta gggctaggtg ggggtcgccg     2400

tggaggggtt agggaggtcc tgagaggcgg gaacagaatg gcacagtggt ctacagtcgc     2460

tgtgtttgat ggttattgaa gggggatgta agaactgtga atttttgggc ctgcagcctg     2520

ggcaggggca accaatccac caccagacac tagtcacgcc cccctccttt ctccatcacc     2580

cgctgtctag gaattcccac aggactccag actctgacaa caggtcccta tgttagaggg     2640

cccgatgaca ctgggatcag ccagctttgg tctccactgc cacctgctgg gctggtctcc     2700

tgggtggagt tcaccatctg tagggagggg agagttctcc tggggcctgc tctactccag     2760

tggggctggc ccaggctcct ggcccatcag agggcctagg gcctaaggac cctgaagtca     2820

agccgggtgg tcactgcctc tgctggagct gcctgtggaa ggaggcattg caaaccaaaa     2880

cctcccagag agtttccttg ctggaaactt ggaaacagcc ctttttatga cattttccag     2940

gggaggggga ggggtactgg cgggggttta gggcagtgac actatttgtg taatgacatc     3000

agctcccaca aggcctcaca gcaatgtcaa cagctggaga gggcctggtt aagtctggaa     3060

tgccagcggc tgtctaggca gtttgaacca ggcttggggg aaggggcttg cctgagtcag     3120

ggtagggtcg ctgctcagca aggtgcctgg cgtccaagct ggagggcaag gccaggaatg     3180

gtcaggttct tggggtccaa gcattctgtg actgcttcct gctgccgccc tcactgctgg     3240

ctccccagaa aagggacata gactccttgg ttaagaaacc cactctagct cccagctgtc     3300

ttggtctagc ctgggcagtc tggtctattc ctttctggct gccttctttg tggaggtccc     3360

caggccctcc tgtatgccta gctctctttt ctcttagaga cttaatgtcc tcacgcaggc     3420

agctccaagc ttcccttctg gttgcttccc aggccccttt agcctttccc tgcctccctg     3480

tactcgggcc tctagcctcg cgccccgcac actggatgag aggcctggcc ctctcagtca     3540

ggaaattggt ttcatttctc ctgcccactt ggctgccctg aagggccata tgagggatga     3600

agctcagccc ctcagtgaca cggctccctc tgcttctcca cttctgccca catcaccact     3660

gccacttact gagcaccctc ttggtgccag gcactttacc catatgctcc tggcctgttt     3720

tcaccacaaa cctgcgaggc agggattcac tcttgtcttc gtgttcacca gtaaaaagac     3780

atgtccacgt gcccaaggtc acaccagcac cggtactcag actctgacct caccacagtt     3840

gcacatcagc agttagccct cttgacactc ccacagtagg cgagggttgg gtgggatagt     3900

ggttaccact gagacccagg cagcttgtct ctagagaact ctgaggatat gagcctggag     3960

tatggtctgg gacagaccca gcaacacctc ctgaggaggc atcgggagtg gcggggaatg     4020

aggaatggac tccctagtgg aaagccgcaa gatccaggaa gacaggcatg gccatctgag     4080

agggcctgga gaggtggctt agctgcttcc ctagccggag gaagactaag gcttcagagg     4140

gaggctggca tgagcacaca gacctaccct ggcaagggtc aggtggcttc cctggtccaa     4200

gcttgagatt gagggcaagg tccactatcc aggagagcca gtatggtttg ttgggtacca     4260

tctgtagcaa ataacatcca gctgtacagc aggggtctca tttctgtacc agcatgtcta     4320

atgctctggc cagcttccac ccttgaaccc tggagtccag tctcacctgg tatccagcga     4380

agtctcttaa ctagacttcc cccacgcccc tgctaagcaa cagagacgtc ttgttagaaa     4440

tctaccaagg cctcctgccc tgccctctgt ggcctgctca atgggggcta cattaaatag     4500

ccaaaatgag ccaagttgtg gataaggtca ttgctgaggg agcagggttt gtcacagcca     4560

ccacctctgt ggaccagaat ccagcccacc tctcctctgc ctgagagcca gccttaggga     4620

ggcagctgtc tcctacccac cctagggagg agatggaaag ggggaagaag acatcctctt     4680

tgtacagtta ggaaggggtg caaaatggaa gtaggttttt gagtttgaga gtgtattaac     4740

agagttgtga tatgtaggtc tttgaagaaa accataccag gttagtcact taccagtcaa     4800

gatttcccag ctgtcccttt gcttaccatt tgggtagtct ggtcccctgt caccagaatg     4860

cctcctttgc tgacacacag tggcacaaag gtatgtggtg aaggtgatga catgctccta     4920

ggtacagctg tgagctgtgg tttctggcca gagcttctgt cccagaaagc agggcaggag     4980

gcaggaccat ccggctcctt cagatgggag ggagggtcag atgccaaggg caaagcctag     5040

ggaggctggg gtggcctctc cgagggcctt agggactttc tagaactctg cctcagtggt     5100

tacatacagg cagtgggtac aggctgtctt agaattgccc ctgagctgga acaagactga     5160

aatgaggaga cccttcagga ctgacctggg gaatggttcc tttagggtct caacacttga     5220

aggactccat ccaggaaacc tagagagtgg gcaagatagg ctcactaatg ggccgtggtt     5280

cacagacaga tattcctgtg gaccagagcc atgccatacc ccaggggtat caaaattgtc     5340

tttgtggggc cttgcccctg ccaaaaacta agccagcctc acctcttgtg tcagcggact     5400

tccttcccct ttccctgatc tgggtacacc cccccggcct ccctcctgtg tcaccgattc     5460

tgctcacaca gaattgtaaa tgtttagttg tgaccatgac atattgtttg ggccagtgtt     5520

cctttccaat gcatactaat atattatggt tattatatat gaatatattt aatgacatgg     5580

agaaagttgt ggattttctt tctttttctt tctttttttt tttaaagttt ttttgttgtt     5640

agagttgtaa tggacccaga cggaacttgt aacgtgggcc ctacatgata gaactaaatc     5700

cagatatcat taaataaact cttgtatact gttctgtgaa aaaaaaaaaa aaaaaaa        5757


<210>  2
<211>  604
<212>  PRT
<213>  Mus musculus

<400>  2

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ser 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Tyr Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Asp Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ala Asn 
                325                 330                 335     


Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe 
            340                 345                 350         


Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys 
        355                 360                 365             


Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys 
    370                 375                 380                 


Glu Gly Phe Tyr Arg Asp Met Gly Lys Pro Ile Thr His Arg Lys Ala 
385                 390                 395                 400 


Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys 
                405                 410                 415     


Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile 
            420                 425                 430         


Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile 
        435                 440                 445             


Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro Thr Thr Ala Ala Ser 
    450                 455                 460                 


Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr Cys Lys Ala Ser Lys 
465                 470                 475                 480 


Gly Lys Leu Lys Met Asn Met Lys Lys Tyr Cys Arg Lys Asp Tyr Ala 
                485                 490                 495     


Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys 
            500                 505                 510         


Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile 
        515                 520                 525             


Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys 
    530                 535                 540                 


Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn 
545                 550                 555                 560 


Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser 
                565                 570                 575     


Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe 
            580                 585                 590         


Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
        595                 600                 


<210>  3
<211>  5954
<212>  DNA
<213>  Homo sapiens

<400>  3
cttcgggggc gagcgcgcgt gtgtgtgagt gcgcgccggc cagcgcgcct tctgcggcag       60

gcggacagat cctcggcgcg gcagggccgg ggcaagctgg acgcagcatg atgcgcgcag      120

tgtgggaggc gctggcggcg ctggcggcgg tggcgtgcct ggtgggcgcg gtgcgcggcg      180

ggcccgggct cagcatgttc gcgggccagg cggcgcagcc cgatccctgc tcggacgaga      240

acggccaccc gcgccgctgc atcccggact ttgtcaatgc ggccttcggc aaggacgtgc      300

gcgtgtccag cacctgcggc cggcccccgg cgcgctactg cgtggtgagc gagcgcggcg      360

aggagcggct gcgctcgtgc cacctctgca acgcgtccga ccccaagaag gcgcacccgc      420

ccgccttcct caccgacctc aacaacccgc acaacctgac gtgctggcag tccgagaact      480

acctgcagtt cccgcacaac gtcacgctca cactgtccct cggcaagaag ttcgaagtga      540

cctacgtgag cctgcagttc tgctcgccgc ggcccgagtc catggccatc tacaagtcca      600

tggactacgg gcgcacgtgg gtgcccttcc agttctactc cacgcagtgc cgcaagatgt      660

acaaccggcc gcaccgcgcg cccatcacca agcagaacga gcaggaggcc gtgtgcaccg      720

actcgcacac cgacatgcgc ccgctctcgg gcggcctcat cgccttcagc acgctggacg      780

ggcggccctc ggcgcacgac ttcgacaact cgcccgtgct gcaggactgg gtcacggcca      840

cagacatccg cgtggccttc agccgcctgc acacgttcgg cgacgagaac gaggacgact      900

cggagctggc gcgcgactcg tacttctacg cggtgtccga cctgcaggtg ggcggccggt      960

gcaagtgcaa cggccacgcg gcccgctgcg tgcgcgaccg cgacgacagc ctggtgtgcg     1020

actgcaggca caacacggcc ggcccggagt gcgaccgctg caagcccttc cactacgacc     1080

ggccctggca gcgcgccaca gcccgcgaag ccaacgagtg cgtggcctgt aactgcaacc     1140

tgcatgcccg gcgctgccgc ttcaacatgg agctctacaa gctttcgggg cgcaagagcg     1200

gaggtgtctg cctcaactgt cgccacaaca ccgccggccg ccactgccat tactgcaagg     1260

agggctacta ccgcgacatg ggcaagccca tcacccaccg gaaggcctgc aaagcctgtg     1320

attgccaccc tgtgggtgct gctggcaaaa cctgcaacca aaccaccggc cagtgtccct     1380

gcaaggacgg cgtgacgggt atcacctgca accgctgcgc caaaggctac cagcagagcc     1440

gctctcccat cgccccctgc ataaagatcc ctgtagcgcc gccgacgact gcagccagca     1500

gcgtggagga gcctgaagac tgcgattcct actgcaaggc ctccaagggg aagctgaaga     1560

ttaacatgaa aaagtactgc aagaaggact atgccgtcca gatccacatc ctgaaggcgg     1620

acaaggcggg ggactggtgg aagttcacgg tgaacatcat ctccgtgtat aagcagggca     1680

cgagccgcat ccgccgcggt gaccagagcc tgtggatccg ctcgcgggac atcgcctgca     1740

agtgtcccaa aatcaagccc ctcaagaagt acctgctgct gggcaacgcg gaggactctc     1800

cggaccagag cggcatcgtg gccgataaaa gcagcctggt gatccagtgg cgggacacgt     1860

gggcgcggcg gctgcgcaag ttccagcagc gtgagaagaa gggcaagtgc aagaaggcct     1920

agcgccgagg cagcgggcgg gcgggcgggc gggcgccagg gcggggccga gcgagagcgg     1980

gcgccttggc ccggccgccg cggacttggc ccgcgagggc tttcccaggt ggggggaggg     2040

agggggcggg gccgcacggc gcggggggcg ggaccctcgg cggcccctcc ccctaccccc     2100

accctgcgcg ctctgggcgg gagccgcgtg cacgcggggc ggggtgcgcc gccggccggg     2160

ccctggagaa atgacgagac gtagctacct cacggggctc cttccagagc agagacgcgc     2220

ttccctgggc ctgggcgcgg ccgccgtgga ggggctgggg gcagcctgcc ctggggcccg     2280

ggggcgggcg cagaatcgca caactggggc cccaggcgcg gggcgtggat ggcgcggaga     2340

cgtggacggg aggagaactg tgaattctca agcccgtagt gtgggcgggg cgcggagcac     2400

ccaccaaacc accacccgac acgcagccga cgggatcccc ccctttctcc ccggcccctt     2460

ctagcagttc cccgcgggcc acctggctgt cacagcctgg actcctccat ctgaaggggc     2520

ctggcagcat ttggggagtg gacagctcct gtccagccag catgccccag gcggcctctg     2580

tctccactgc tacctgctga gtgggtccta ctgggtgggg gcttggggtc ggtgagtggt     2640

tcacctgtgg agagaggaga ggaagcccct gctgctgcct gtctctgccc ctgcccctgc     2700

ccctgcccag cgtggggctg gcccatccgg aaggcagtgg gcccagggac acccctgaga     2760

agcccaagcc gggtggtcac cgcctcatgc tggagctgcc tgttggagga ggcatcgcaa     2820

acgcaaaacc tcccagagag tttccttttg gaaacttgga accagccctt tttatgacgt     2880

tttccagggg gagggggagg ggcactggct gggtttacgg cagtgacact atttatgtaa     2940

atgacatcag ctcccgcaag gcccctcagc aatgtcaaca gctggaaagg gcctgaacgg     3000

gcttggagtc tgcaggctgc gaaggcactt gggcctggct tggggccggg ggcttgtttg     3060

agctgggatg gggtttgctg gctcagtgaa gtaccagagt gcctgagcca tgggtgggca     3120

ggggcacagg aatgaccagg ttcctggggg ccaaggaggc catgctggct tctccaaggg     3180

aaggcacaga ggctgccggc ctgcccccta cagctgtctt gggtctggcc tgggccacac     3240

cttgaccgtg cctttccaga cggtctttgt ggagtctgcc cgtgccctcc actgtgcccc     3300

agccctcctt ccaaaatctc ctagagacac ggtcctcaag caggcagccc cttttgttct     3360

gacctcctca cacagggtcc attcctgtgc cctggggcct cctggctccc tgccttcctg     3420

ggctctctgc actgcccggg cctctggccc acatcctcac acccggcgca ctgaattaag     3480

aggcctggct cccctcacag tcaggaaatt ggtttcactt tcccggccag agtttggctg     3540

ctcaaaaggg tcataccaag tatgaagctc ggcccccggt ggtctggctt ccctccgcct     3600

tccccacatt tacccgcatc acggctgcca tttattgagc acctgctgtg tgccaggcac     3660

tttacccaca tgctcccagt gtgtactcat gacaaccctg tgggacaggg actcattatc     3720

accagcaagg agactggagt acacgtgccc aaggtcatgc tgcaaattgg tggcaggact     3780

ggggctcaaa ctccagagcc cgactttctg accaggggcc acgctggccc tcactgcact     3840

ccagctctgc agcctacccg cccaatccct gtgcaggctg ggagggtgct cttgggggag     3900

tggccaccga gcccctggcc ctggttactg cctcttgagg acactggcat ctgggctgga     3960

gaacaggagc ccggggtggg gtagggcatg gggacaatca catcttcaga ggaggcagca     4020

aagtggtgcg ggatgcaggg acggacttgc cagatggcag ctccaggttc caggaaggca     4080

ggccttggat gctccgaaga ggtggtagaa aggtgttttt agaaaggtgt tttggctgcc     4140

tcagggtggt tggagagact ccaggagaga ctggcagagg tgcctcaggg gcagggagca     4200

gacagacctg ccctgggaag gggcatttgg cttccctgaa tccagcccaa ggctagaaga     4260

cagggcccct ctccaagctg tcagcgcccc tcggatgccc agtgtggtgt gctgggcgcc     4320

atcagcatca caaggcacta cgctgctggg gcggttgtcc tatttctgtc tatgccagtg     4380

tggtttcttc accctgccca gaagggctgt ggcagcccca cgatatccca ccctgggtct     4440

gggtctcacg ggtgtcctgt gaggggcttg catttgtggt ggtctctgag gccacctcag     4500

caacggagct ggcgacacgc caagcaacaa ggcatcttgc ggaaaattca gccagtgtcc     4560

tgcccctccc ttcggctcag caccccgcag ggcacaggct gtccgcccgg tggtctggcc     4620

cttggggaat gcgtcagggt gaccagatcc accatgctag cagccaggtc actgttggga     4680

ttgcacggtc gtcacgagct gcctttccta tccacacacc cagccaggac ccagcccacc     4740

actcccgact gcagccccgg cctctgcggt gagcaccatc cttgggaaag cacccctcct     4800

ccactccggt gccccactcc aaggagcaga gggaaatggg aattgaggtg tcccggtttg     4860

tacagttagg aagggatgta aaacggaact agattttgat tttgaagagt gtattaacca     4920

gaattgtgct atgtaggtgt ttgtttgaag aaaaacatac cagattagtc tttgtttttg     4980

aaacagcttc cccagttgtc ctttttctta ccagctgggt ggtctggtgc ccctgacagc     5040

tgagtgcctg ctttacggac acgcagtaat gccgaagatt tgcgggggag gacatagggc     5100

tgtccccggg attcacctgc tggctgtggt ctctgcccac tgcttctgtc cttggaaagc     5160

agggcaggag gcagcatccc caggggcctc tatgtgggag ggagggacac ctggggtcac     5220

aacccaggga gggagggtca cagcccaggg aggctgggag ctgctccaag gccctggaac     5280

tctgcctcag tcgcggcatg ctggagaggg gtacggactt actttcttgg agttgtccca     5340

ggttggaatg agactgaact caagaagaga ccctaaggga ctggggaatg gttcctgcct     5400

tcaggaaagt gaaagacgct taggctgtca acacttaaag gaagtcccct tgaagcccag     5460

agtggacaga ctagacccat tgatggggcc actggccatg gtccgtggac aagacattcc     5520

tgtgggccat ggcacaccgg gggggatcaa aatgtgtact tgtggggtct cgccccttgc     5580

caaaagccaa accagtccca ctcctgtcat tggacgtttc ttcccattcc ctcctcccaa     5640

atgcacttcc cctcctccct ctgccccctc ctgtgttttg gatttctgtt cactcagaat     5700

tgtaaatgtt tagttgtgac catgacgtat tgtttgggtc aatgtccctt tccaatgcat     5760

actaatatat tatggttatt atatatgaat atatttaatg acatggaaaa agttgtggat     5820

tttctttctt tccttttttt tggggggggg tggggggttg gttagagttg taatggaccc     5880

agatggaact tgtaatgtgg gccccacatg atagaactaa attcagatat cattaaataa     5940

actcttgtac acta                                                       5954


<210>  4
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Asp Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ala Asn 
                325                 330                 335     


Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe 
            340                 345                 350         


Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys 
        355                 360                 365             


Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys 
    370                 375                 380                 


Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr His Arg Lys Ala 
385                 390                 395                 400 


Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys 
                405                 410                 415     


Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile 
            420                 425                 430         


Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile 
        435                 440                 445             


Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro Thr Thr Ala Ala Ser 
    450                 455                 460                 


Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr Cys Lys Ala Ser Lys 
465                 470                 475                 480 


Gly Lys Leu Lys Ile Asn Met Lys Lys Tyr Cys Lys Lys Asp Tyr Ala 
                485                 490                 495     


Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys 
            500                 505                 510         


Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile 
        515                 520                 525             


Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys 
    530                 535                 540                 


Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn 
545                 550                 555                 560 


Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser 
                565                 570                 575     


Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe 
            580                 585                 590         


Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
        595                 600                 


<210>  5
<211>  2411
<212>  DNA
<213>  Mus musculus

<400>  5
gagaaggacg ggaccgagcc tcggcggcca cagaaggtgg gaaaagcgga ggaggacagc       60

cgggaggcgg cggcggccgg gaagtgaaag gtctcgcaaa gttcagcgtc ggctgcgggc      120

gccgagccct gggcgagcgg cgcacccgcc ctcagggccg ctcagccggc agcggccagg      180

ccggctatga tcccggggct cccgccgctg ctgagctgcc cgggccccgc caggccggtg      240

cgcgacggtc accccgccgc ctggcgcggc cccggcccgc ggctctgtgc ccacggtgcc      300

cactgagcga gcctggcgct ccgggaggag gaagaaccac agagcccccg gtgctcccga      360

ggaccactgc cgcttcatcc cacccgctcc cgcagctgcc cggccatggg gagctgcgca      420

cggctgctgc tgctctgggg ctgctccgcg gtggccgcag gcttgaatgg agtagccgga      480

gcgaactccc gctgtgagaa agcatgcaac cctcgcatgg gaaacttggc tttgggaaga      540

aagctccggg cagacacaat gtgtggccag aacgccaccg aactcttctg cttctacagt      600

gagaatgctg acctcacttg ccggcagccc aagtgtgata aatgcaacgc tgcccattct      660

cacctggctc acccaccctc tgccatggca gactcatcct tcaggtttcc ccggacatgg      720

tggcagtctg cagaggatgt gcacagggaa aagattcagc tagacctgga agcagaattc      780

tacttcactc acctaattat ggtgttcaag tctcccaggc ctgcagccat ggtgctggac      840

cggtcccagg actttgggaa gacctggaag ccttacaagt actttgcaac aaactgctcg      900

gctacttttg gcctggaaga tgatgttgtc aagaagggag ctatttgcac gtctagatac      960

tcaaatcctt tcccgtgcac cggaggagag gttattttca gagccctgtc accaccatac     1020

gacatagaaa acccttacag tgccaaagtg caggagcagc tgaagatcac caacctccga     1080

gtgcggctgc tcaagcgaca gtcctgccct tgtcagataa acgacctgaa cgcaaaacct     1140

caccatttta tgcactacgc agtctatgac ttcatcgtca agggcagctg cttctgcaac     1200

ggccacgctg accagtgctt acctgtggag ggcttcagac ccatcaaggc cccgggagcg     1260

ttccacgtgg tccacgggag gtgtatgtgt aagcacaaca cagcaggcag ccactgccag     1320

cactgtgcac cattgtacaa tgaccggccc tgggaggcag cggacggcag aacaggggct     1380

cctaacgaat gcagaacttg caagtgcaat gggcacgcgg acacctgtca cttcgacgtc     1440

aacgtgtggg aggcgtcggg gaaccgcagc ggcggtgtct gcaacaactg tcagcacaac     1500

actgagggtc agcactgtca acgctgtaag cccggtttct accgcgacct cagaagaccc     1560

ttctctgccc ctgacgcttg caaagcgtgt tcctgccacc cggttggatc ggcgatcctt     1620

cctttcagct cagtgacctt ctgcgacccc agcaatggtg actgcccctg caagcctggg     1680

gtggcggggc cacattgcga cagatgcatg gtgggatact ggggctttgg agactacggc     1740

tgcagacctt gcgattgtgc ggggagctgc gacccgctca cgggagactg catcagcagt     1800

aacgctgatg tagactggta ccacgaagtc cccgcctttc actcgatgca caataagagt     1860

gagcccagct gggaatggga ggatgagcaa ggattttctg ccctccgaca ctcaggtaaa     1920

tgtgaatgta aggaacaggt gttaggaaac cccaaagcct tctgtggaat gaagtattca     1980

tatgtgttaa aaatcaagat cttatcagcc cacgacaaag gctcccatgc cgaagtcaat     2040

gtgaagatta agaaagtctt aaagtccacc aaactgaaga tcttacgagg caagagaacg     2100

ctatacccag agtcctggac taacagaggc tgcacctgtc caatcctcaa tccaggattg     2160

gagtacctgg tcgctggcca cgaggacgta agaacaggca aattaattgt gaatatgaaa     2220

agctttgtcc agcactggaa accagctctt ggcagaagag tcatgcacat cttaaaaaga     2280

gactgcgtgt agcactgaag gtcttaagca cacaagggct tttctctggg tagcagatac     2340

acaagtctaa tgaaaaagag acctcaaaat aaaactggaa tattttttaa gtgccaaaat     2400

gtaggggggg g                                                          2411


<210>  6
<211>  628
<212>  PRT
<213>  Mus musculus

<400>  6

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Ser Ala Val 
1               5                   10                  15      


Ala Ala Gly Leu Asn Gly Val Ala Gly Ala Asn Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Arg 
        35                  40                  45              


Ala Asp Thr Met Cys Gly Gln Asn Ala Thr Glu Leu Phe Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Ala Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala His Ser His Leu Ala His Pro Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Met Val Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Arg Tyr Ser Asn Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Arg Ala Leu Ser Pro Pro Tyr Asp Ile Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Arg Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Ile Asn Asp 
225                 230                 235                 240 


Leu Asn Ala Lys Pro His His Phe Met His Tyr Ala Val Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Leu 
            260                 265                 270         


Pro Val Glu Gly Phe Arg Pro Ile Lys Ala Pro Gly Ala Phe His Val 
        275                 280                 285             


Val His Gly Arg Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Gly Arg Thr Gly Ala Pro Asn Glu Cys Arg Thr Cys Lys Cys Asn Gly 
                325                 330                 335     


His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly 
            340                 345                 350         


Asn Arg Ser Gly Gly Val Cys Asn Asn Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln His Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg 
    370                 375                 380                 


Pro Phe Ser Ala Pro Asp Ala Cys Lys Ala Cys Ser Cys His Pro Val 
385                 390                 395                 400 


Gly Ser Ala Ile Leu Pro Phe Ser Ser Val Thr Phe Cys Asp Pro Ser 
                405                 410                 415     


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Pro His Cys Asp 
            420                 425                 430         


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro 
        435                 440                 445             


Cys Asp Cys Ala Gly Ser Cys Asp Pro Leu Thr Gly Asp Cys Ile Ser 
    450                 455                 460                 


Ser Asn Ala Asp Val Asp Trp Tyr His Glu Val Pro Ala Phe His Ser 
465                 470                 475                 480 


Met His Asn Lys Ser Glu Pro Ser Trp Glu Trp Glu Asp Glu Gln Gly 
                485                 490                 495     


Phe Ser Ala Leu Arg His Ser Gly Lys Cys Glu Cys Lys Glu Gln Val 
            500                 505                 510         


Leu Gly Asn Pro Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu 
        515                 520                 525             


Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Ser His Ala Glu Val 
    530                 535                 540                 


Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Leu 
545                 550                 555                 560 


Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asn Arg Gly Cys 
                565                 570                 575     


Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His 
            580                 585                 590         


Glu Asp Val Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val 
        595                 600                 605             


Gln His Trp Lys Pro Ala Leu Gly Arg Arg Val Met His Ile Leu Lys 
    610                 615                 620                 


Arg Asp Cys Val 
625             


<210>  7
<211>  3634
<212>  DNA
<213>  Homo sapiens

<400>  7
ggacgggacg gagccggggc agccagaaga ggtgggaaaa gcggaggagg acgcccagga       60

ggaggcggcg gcggcggccg ggaagtgaaa ggtctcgcaa agttcagcgg cggctgcggg      120

cgccgagccc cgggctagcg gcagacgagc ccgcagggcc gctccgcggg gcagcgcagc      180

caggccggct atggtcccgg ggctcccgcc gccccccagg tgcccgggac ccgccaggcc      240

ggtgcgcgag ggtcacccca cctccccgcg cggtcccggc ccctggctcc cagctgccgg      300

cgaccgctga ccgagcccgg cgccccagga ggaggaagaa accagggccc cgttccctcc      360

cgaggacggc ggcgcttcat cccgcagccc agaggtctcg gctccctccg gcacccgccc      420

ggcccggctg ctcccggctc ctcccggcca tggggagctg cgcgcggctg ctgctgctct      480

ggggctgcac ggtggtggcc gcaggactga gtggagtagc tggagtgagt tcccgctgtg      540

aaaaagcctg caaccctcgg atgggaaatt tggctttggg gcgaaaactc tgggcagaca      600

ccacctgcgg tcagaatgct accgaactgt actgcttcta cagtgagaac acggatctga      660

cttgtcggca gcccaaatgt gacaagtgca atgctgccta tcctcacctg gctcacctgc      720

catctgccat ggcagactca tccttccggt ttcctcgcac atggtggcag tctgcggagg      780

atgtgcacag agaaaagatc cagttagacc tggaagctga attctacttc actcacctaa      840

ttgtgatgtt caagtccccc aggccggctg ccatggtgct ggaccgctcc caggactttg      900

ggaaaacatg gaagccttat aagtactttg cgactaactg ctccgctaca tttggcctgg      960

aagatgatgt tgtcaagaag ggcgctattt gtacttctaa atactccagt ccttttccat     1020

gcactggagg agaggttatt ttcaaagctt tgtcaccacc atacgataca gagaaccctt     1080

acagtgccaa agttcaggag cagctgaaga tcaccaacct tcgcgtgcag ctgctgaaac     1140

gacagtcttg tccctgtcag agaaatgacc tgaacgaaga gcctcaacat tttacacact     1200

atgcaatcta tgatttcatt gtcaagggca gctgcttctg caatggccac gctgatcaat     1260

gcatacctgt tcatggcttc agacctgtca aggccccagg aacattccac atggtccatg     1320

ggaagtgtat gtgtaagcac aacacagcag gcagccactg ccagcactgt gccccgttat     1380

acaatgaccg gccatgggag gcagctgatg gcaaaacggg ggctcccaac gagtgcagaa     1440

cctgcaagtg taatgggcat gctgatacct gtcacttcga cgttaatgtg tgggaggcat     1500

cagggaatcg tagtggtggt gtctgtgatg actgtcagca caacacagaa ggacagtatt     1560

gccagaggtg caagccaggc ttctatcgtg acctgcggag acccttctca gctccagatg     1620

cttgcaaacc gtgttcctgc catccagtag gatcagctgt ccttcctgcc aactcagtga     1680

ccttctgcga ccccagcaat ggtgactgcc cttgcaagcc tggggtggca gggcgacgtt     1740

gtgacaggtg catggtggga tactggggct tcggagacta tggctgtcga ccatgtgact     1800

gtgcggggag ctgtgaccct atcaccggag actgcatcag cagccacaca gacatagact     1860

ggtatcatga agttcctgac ttccgtcccg tgcacaataa gagcgaacca gcctgggagt     1920

gggaggatgc gcaggggttt tctgcacttc tacactcagg taaatgcgaa tgtaaggaac     1980

agacattagg aaatgccaag gcattctgtg gaatgaaata ttcatatgtg ctaaaaataa     2040

agattttatc agctcatgat aaaggtactc atgttgaggt caatgtgaag attaaaaagg     2100

tcttaaaatc taccaaactg aagattttcc gaggaaagcg aacattatat ccagaatcat     2160

ggacggacag aggatgcact tgtccaatcc tcaatcctgg tttggaatac cttgtagcag     2220

gacatgagga tataagaaca ggcaaactaa ttgtgaatat gaaaagcttt gtccagcact     2280

ggaaaccttc tcttggaaga aaagtcatgg atattttaaa aagagagtgc aagtagcatt     2340

aagatggata gcacataatg gcacttgtct atgtacaaaa cacaaacttt agagcaagaa     2400

gacctcagac aggaaactgg aattttttaa agtgccaaaa catatagaaa tgtttgaatg     2460

catgggtctt atctaactta tctcttctgg acccatgttt aaatacagtt ttatttcatg     2520

aagagaaatg aaaaccccta cactgatatc tgttttctat gggactgatt ctgaaattct     2580

taactattaa gaatatttta atagcagcat gacatttagc agtaatccat taagggcagt     2640

acctctaaca aggacgcctt ccagcttcag cgatgttact tacgtttgat gctacttaaa     2700

gtaatgaatg acgttttaag gaatccctaa ccctactatc agaaaaggtg tttgttaaag     2760

agccttctct tgtgtgttac gcatgaactt tggtctgtag gtgttaaatg gaacctctcc     2820

atgtgtatat agtatttcct tgtataaagc actttactac ctaccacttg tgttgtgaac     2880

gtttggtgac tgctgttgaa agaaggaaaa gggtgtgtga gaaagcctac tgaagcagca     2940

gcactgccac tacatgtgga caaaagtgac catataaaag aagttgtgct atttaactct     3000

gaatacttgg agaaactagg tgaagatgca accagaaagg agaatatgta tgcgtgaagt     3060

ctcagctttg agctggaggc tagattccaa gatgacagcc atgatgaaac tttttaaaaa     3120

actaaaccag aagagacttt aaaataagag aaagaaatca taaatgtaga catatgcttg     3180

gctaaagggg aaatggactt taaattttaa agagctcatt tgcaatgcac ttgtatacac     3240

ttcaaaaatt attgtagaca cagaatttgt tatatttttg tgcttagtat ttaaacctga     3300

acattgaaac agttttcctc cttgtctttc ttaacagtaa tagtcattat atttacctgt     3360

tttttaacac aatgtatgtg atagtcaaaa aatcacagtt tttcattatt attcatcttc     3420

tgtacccacg cataaccact atacatagtt tcttttgtac ttgaatatac aaaacatgaa     3480

cacagtgcca tatgaataat ttcacataca gaaccttttt ttctctgaag tcctgtggac     3540

ttgcaaatat atatatatat tgctttgtta atttgttttt atatttcata tatgtaataa     3600

aggaatatga tctgaaaaaa aaaaaaaaaa aaaa                                 3634


<210>  8
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Thr Cys Lys Cys Asn Gly 
                325                 330                 335     


His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly 
            340                 345                 350         


Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg 
    370                 375                 380                 


Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val 
385                 390                 395                 400 


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
                405                 410                 415     


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
            420                 425                 430         


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro 
        435                 440                 445             


Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser 
    450                 455                 460                 


Ser His Thr Asp Ile Asp Trp Tyr His Glu Val Pro Asp Phe Arg Pro 
465                 470                 475                 480 


Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly 
                485                 490                 495     


Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr 
            500                 505                 510         


Leu Gly Asn Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu 
        515                 520                 525             


Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val 
    530                 535                 540                 


Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe 
545                 550                 555                 560 


Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys 
                565                 570                 575     


Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His 
            580                 585                 590         


Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val 
        595                 600                 605             


Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys 
    610                 615                 620                 


Arg Glu Cys Lys 
625             


<210>  9
<211>  7949
<212>  DNA
<213>  Homo sapiens

<400>  9
gggagaggga gacgcaggcg gcgaaacggc agaggagccg agccccctcc gcccaaggcg       60

ccctccctcc gtccgcgcac aggcgccgtc gcttggagga gcaaggtgcc tcccagcccg      120

caggggcgcc gcgcgcaagc ccgcgggctc ttcggtggct ctgccccggg actgcacctg      180

gaggcggccc cggacgggga tggtcagcgg ctgctgccgt ctggctcgcg agcgggacgc      240

tgtgagggca ccatggcgct gactcccggg tgggggtcct cggcggggcc ggtccggccg      300

gagctctggc tgctgctgtg ggcagccgcg tggcgcctgg gtgcctcggc gtgccccgcc      360

ctctgcacct gcaccggaac cacggtggac tgccacggca cggggctgca ggccattccc      420

aagaatatac ctcggaacac cgagcgcctg gaactcaatg gcaacaacat cactcggatc      480

cataagaatg actttgcggg gctcaagcag ctgcgggtgc tgcagctgat ggagaaccag      540

attggagcag tggaacgtgg tgcttttgat gacatgaagg agctggagcg gctgcgactg      600

aaccgaaacc agctgcacat gttaccggaa ctgctgttcc agaacaacca ggctttgtca      660

agactggact tgagtgagaa cgccatccag gccatcccca ggaaagcttt tcggggagct      720

acggacctta aaaatttaca gctggacaag aaccagatca gctgcattga ggaaggggcc      780

ttccgtgctc tgcgggggct ggaggtgctg accctgaaca acaacaatat caccaccatc      840

cccgtgtcca gcttcaacca tatgcccaag ctacggacct tccgcctgca ctccaaccac      900

ctgttttgcg actgccacct ggcctggctc tcgcagtggc tgaggcagcg gccaaccatc      960

gggctcttca cccagtgctc gggcccagcc agcctgcgtg gcctcaatgt ggcagaggtc     1020

cagaagagtg agttcagctg ctcaggccag ggagaagcgg ggcgcgtgcc cacctgcacc     1080

ctgtcctccg gctcctgccc ggccatgtgc acctgcagca atggcatcgt ggactgtcgt     1140

ggaaaaggcc tcactgccat cccggccaac ctgcccgaga ccatgacgga gatacgcctg     1200

gagctgaacg gcatcaagtc catccctcct ggagccttct caccctacag aaagctacgg     1260

aggatagacc tgagcaacaa tcagatcgct gagattgcac ccgacgcctt ccagggcctc     1320

cgctccctga actcgctggt cctctatgga aacaagatca cagacctccc ccgtggtgtg     1380

tttggaggcc tatacaccct acagctcctg ctcctgaatg ccaacaagat caactgcatc     1440

cggcccgatg ccttccagga cctgcagaac ctctcactgc tctccctgta tgacaacaag     1500

atccagagcc tcgccaaggg cactttcacc tccctgcggg ccatccagac tctgcacctg     1560

gcgcagaacc ctttcatttg cgactgtaac ctcaagtggc tggcagactt cctgcgcacc     1620

aatcccatcg agacgagtgg tgcccgctgt gccagtcccc ggcgcctcgc caacaagcgc     1680

atcgggcaga tcaagagcaa gaagttccgg tgctcagcca aagagcagta cttcattcca     1740

ggcacggagg attaccagct gaacagcgag tgcaacagcg acgtggtctg tccccacaag     1800

tgccgctgtg aggccaacgt ggtggagtgc tccagcctga agctcaccaa gatccctgag     1860

cgcatccccc agtccacggc agaactgcga ttgaataaca atgagatttc catcctggag     1920

gccactggga tgtttaaaaa acttacacat ctgaagaaaa tcaatctgag caacaacaag     1980

gtgtcagaaa ttgaagatgg ggccttcgag ggcgcagcct ctgtgagcga gctgcaccta     2040

actgccaacc agctggagtc catccggagc ggcatgttcc ggggtctgga tggcttgagg     2100

accctaatgc tgcggaacaa ccgcatcagc tgcatccaca acgacagctt cacgggcctg     2160

cgcaacgtcc ggctcctctc gctctacgac aaccagatca ccaccgtatc cccaggagcc     2220

ttcgacaccc tccagtccct ctccacactg aatctcctgg ccaacccttt caactgcaac     2280

tgccagctgg cctggctagg aggctggcta cggaagcgca agatcgtgac ggggaacccg     2340

cgatgccaga accctgactt tttgcggcag attcccctgc aggacgtggc cttccctgac     2400

ttcaggtgtg aggaaggcca ggaggagggg ggctgcctgc cccgcccaca gtgcccacag     2460

gagtgcgcct gcctggacac cgtggtccga tgcagcaaca agcacctgcg ggccctgccc     2520

aagggcattc ccaagaatgt cacagaactc tatttggacg ggaaccagtt cacgctggtt     2580

ccgggacagc tgtctacctt caagtacctg cagctcgtgg acctgagcaa caacaagatc     2640

agttccttaa gcaattcctc cttcaccaac atgagccagc tgaccactct gatcctcagc     2700

tacaatgccc tgcagtgcat cccgcctttg gccttccagg gactccgctc cctgcgcctg     2760

ctgtctctcc acggcaatga catctccacc ctccaagagg gcatctttgc agacgtgacc     2820

tccctgtctc acctggccat tggtgccaac cccctatact gtgactgcca cctccgctgg     2880

ctgtccagct gggtgaagac tggctacaag gaaccgggca ttgctcgttg tgctgggccc     2940

caggacatgg agggcaagct gctcctcacc acgcctgcca agaagtttga atgccaaggt     3000

cctccaacgc tggctgtcca ggccaagtgt gatctctgct tgtccagtcc gtgccagaac     3060

cagggcacct gccacaacga cccccttgag gtgtacaggt gcgcctgccc cagcggctat     3120

aagggtcgag actgtgaggt gtccctggac agctgttcca gtggcccctg tgaaaatggg     3180

ggcacctgcc atgcacagga gggcgaggat gccccgttca cgtgctcctg tcccaccggc     3240

tttgaaggac caacctgtgg ggtgaacaca gatgactgtg tggatcatgc ctgtgccaat     3300

gggggcgtct gtgtggatgg tgtgggcaac tacacctgcc agtgccccct gcagtatgag     3360

ggaaaggcct gtgagcagct ggtggacttg tgctctccgg atctgaaccc atgtcaacac     3420

gaggcccagt gtgtgggcac cccggatggg cccaggtgtg agtgcatgcc aggttatgca     3480

ggtgacaact gcagtgagaa ccaggatgac tgcagggacc accgctgcca gaatggggcc     3540

cagtgtatgg atgaagtcaa cagctactcc tgcctctgtg ctgagggcta cagtggacag     3600

ctctgtgaga tccctcccca tctgcctgcc cccaagagcc cctgtgaggg gactgagtgc     3660

cagaatgggg ccaactgtgt ggaccagggc aacaggcctg tgtgccagtg cctcccaggc     3720

ttcggtggcc ctgagtgtga gaagttgctc agtgtcaact ttgtggatcg ggacacttac     3780

ctgcagttca ctgacctgca aaactggcca cgggccaaca tcacgttgca ggtctccacg     3840

gcagaggaca atgggatcct tctgtacaac ggggacaacg accacattgc agttgagctg     3900

taccagggcc atgtgcgtgt cagctacgac ccaggcagct accccagctc tgccatctac     3960

agtgctgaga cgatcaacga tgggcaattc cacaccgttg agctggttgc ctttgaccag     4020

atggtgaatc tctccattga tggcgggagc cccatgacca tggacaactt tggcaaacat     4080

tacacgctca acagcgaggc gccactctat gtgggaggga tgcccgtgga tgtcaactca     4140

gctgccttcc gcctgtggca gatcctcaac ggcaccggct tccacggttg catccgaaac     4200

ctgtacatca acaacgagct gcaggacttc accaagacgc agatgaagcc aggcgtggtg     4260

ccaggctgcg aaccctgccg caagctctac tgcctgcatg gcatctgcca gcccaatgcc     4320

accccagggc ccatgtgcca ctgcgaggct ggctgggtgg gcctgcactg tgaccagccc     4380

gctgacggcc cctgccatgg ccacaagtgt gtccatgggc aatgcgtgcc cctcgacgct     4440

ctttcctaca gctgccagtg ccaggatggg tactcggggg cactgtgcaa ccaggccggg     4500

gccctggcag agccctgcag aggcctgcag tgcctgcatg gccactgcca ggcctcaggc     4560

accaaggggg cacactgtgt gtgtgacccc ggcttttcgg gcgagctgtg tgagcaagag     4620

tccgagtgcc ggggggaccc tgtccgggac tttcaccagg tccagagggg ctatgccatc     4680

tgccagacca cgcgccccct gtcatgggtg gagtgccggg gctcgtgccc aggccagggc     4740

tgctgccagg gccttcggct gaagcggagg aagttcacct ttgagtgcag cgatgggacc     4800

tcttttgccg aggaggtgga aaagcccacc aagtgtggct gtgccctctg cgcatagcgc     4860

tgggcgtgga caggccggtg agggcgggca aggggcccca gccgctgcag cagcggagac     4920

agtcgccagc agctgggctg gggtgcaggt catcacagga cggctcctgg gcagctgggc     4980

cctcctgggt ggggtggtgc cagagcagcc ttttaaaagc aaattgcgcc atagctgggg     5040

gcagcggggg tgggcgaggc ctgagctgcg ggctgccctc tccggaagtg ccttgcacaa     5100

ataggcgctt aataaatatt tgttgagtga atgtgtgcgt gaggtcaggc caagaagtgc     5160

agaacgatga cacccctcct tacctgctat ctgaatctgg agaagaaaaa tgacagcctt     5220

ccaaaccaac ccttcccttt ggcctgtggc ccaggctggc ttggaactgg gtctgtggcc     5280

ccagaagcct cttacccctc tgcgggcaac catgaagtac tgtcagcctc cccgggaagc     5340

cagcctggtt cattctgctg ctacagaatc tgctggtggt aggccaggct ctggagcggg     5400

ggtgccgcct cctgctggcc agggagggtc ggacccttgc cccctgggct gactggcagc     5460

tctgcagcca cggcttggga acgaggctgt gggtggaggt ggttcttagg accaggcctc     5520

tgaatcctaa agttctagca tgactactgt agctgcgagg gcttatgtgg aggaaacagt     5580

cacaggggct gctcagggtg gcagacccca ctaaagaggg cagagggttc tttgctctag     5640

ataaacaaac atcatctgcc tccagacact ggccacagta ggagtattgg tcctgggctt     5700

ccccagccac cagtcagcca caagctgtcg gtgacctatt ggtagaggga ctgggtgtga     5760

gggtctgggc cagggtgctt gacctgggag cagctggttc agagtccttc acaccgcagg     5820

ccagtaggga gcagtggaag ggacagtgct ccaggcattg ggaagtccct gctggctcta     5880

tcactcgggg caaacttctc cccacctggg ccttgggttc ttcagctata aaatggccag     5940

aggtgggggg cgggatgact aaaggaacag tgcagactcc cccactgtgg tcttgggagg     6000

ccagaggagt tagaagacct atctatctat ctatctatct acattgatca catcaaaagt     6060

atttatgtgc ctaacccggg gctggggatt gtggacgttc tggcctaatg gacagatgtg     6120

aactcatccc agagcatcgc aggaatgacc aggatgcccg ggaagagttg agctgagtgg     6180

gggctccagc cacagacagc ggcccaggcc agggagttgc tggcaacgaa ggagccagtg     6240

gtggaagaag aagaggccct gaatatacga ttgcctgccc acgttgtctt ctcttccata     6300

cacagtgaaa atgtagaaag atggtttgtg aggccaaact gtgaatgggc taaagggagg     6360

caaagttgca ctctccttcc ccagagggct caccaagagg gcacaccccc gggggttctg     6420

gtgggcaacg ggggtgagca tgtccctgcc ctggctccct ccatctgtga ccaggaggca     6480

tggctgggtg tatgttcagg tgaggctcag agtggcattg tgtccctgtc ccctgcccag     6540

ggcagtgagg ggagcccttg atgctgatta gaaggctaga actggggtag aggtgcctgg     6600

catgtctcat gccatgggga ctcaatctag caactgtgag tcctggggtc cctgtgatgg     6660

gaagagggca gtgccctgcc caatgtggca ggtgtcctca tggcaggatc tgcccctcac     6720

cagggggctg ggatctactt gcttggagct ctgagcaagg ccacaatgcc cgcccccacc     6780

cccaagtaga ctgcagcctg ggcctcatgg ggcttctccc aggcccacat ggcatccctc     6840

tctgagtttc caggccaccg tgggaccctg cagagcatct gcaccgggct ggatagggca     6900

gaaaagctca agggcagcta gcttgcctct tccctggaag aaaggtgctc tgggactcac     6960

caaccctgag aaagatagct ttcctggcca ccaccattcc ccaccaccct ggagaagcca     7020

attcccaggc ttgaagggca ctggctggca ggaggcctct tcattctgca ggaggtggaa     7080

aggacacctg tagacaggtg atgctcaccc ctcacctggc gccatggggc tgggaggtga     7140

gcggctggca tgtttgttcc tagggagcac catgtgagct taaggctccc ctgaccggcc     7200

ccaccacatg gcccagcctc ctagcacagc agcgctgacc tcagtgcagt ctgaggattg     7260

gaatccacca tgagatgatg tgagagctgt gtgccccagg atcaactttt tctccaactt     7320

ggccatcagc cagcgagttg ctaaggacct gagtcagcac tcacgttgcc tattcacact     7380

ccgcttgaaa gtccggaagg tggctactgc aaaatcaccc ctctgagaag tcctctctcc     7440

acatcttgtc cccctttgtg aagaccccta gttcgctctg cattttaggc atgaagagat     7500

acagcagggt gcgtccggag ggagctgtgg ccttgcaaca ccactggcaa cagggccggg     7560

gctcccggtg aaggtgtcag gaagtggaaa aggctggact ttgtctcctc tttgcctgct     7620

ggtagcctaa ccgcaaaagt atctctttat acagaatact tacagattct aatatatatt     7680

tgtatttcat tttgttacag tatttttata tgttaaagtc aacatccagc gtcttgtttt     7740

gcctttcaga tgctatgtgg tcgtggcacg ttttgttggg ggtttctgta gtcgtcttgt     7800

ttggatcaac tcctagaggc tggtttagaa caggcccatg agggagctgc acctgccctg     7860

gaagtattgt tttagactat gtcgatattg tctgttgtct tccatgtgaa catgacattg     7920

agtcactctg caaaaaaaaa aaaaaaaaa                                       7949


<210>  10
<211>  1534
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Leu Thr Pro Gly Trp Gly Ser Ser Ala Gly Pro Val Arg Pro 
1               5                   10                  15      


Glu Leu Trp Leu Leu Leu Trp Ala Ala Ala Trp Arg Leu Gly Ala Ser 
            20                  25                  30          


Ala Cys Pro Ala Leu Cys Thr Cys Thr Gly Thr Thr Val Asp Cys His 
        35                  40                  45              


Gly Thr Gly Leu Gln Ala Ile Pro Lys Asn Ile Pro Arg Asn Thr Glu 
    50                  55                  60                  


Arg Leu Glu Leu Asn Gly Asn Asn Ile Thr Arg Ile His Lys Asn Asp 
65                  70                  75                  80  


Phe Ala Gly Leu Lys Gln Leu Arg Val Leu Gln Leu Met Glu Asn Gln 
                85                  90                  95      


Ile Gly Ala Val Glu Arg Gly Ala Phe Asp Asp Met Lys Glu Leu Glu 
            100                 105                 110         


Arg Leu Arg Leu Asn Arg Asn Gln Leu His Met Leu Pro Glu Leu Leu 
        115                 120                 125             


Phe Gln Asn Asn Gln Ala Leu Ser Arg Leu Asp Leu Ser Glu Asn Ala 
    130                 135                 140                 


Ile Gln Ala Ile Pro Arg Lys Ala Phe Arg Gly Ala Thr Asp Leu Lys 
145                 150                 155                 160 


Asn Leu Gln Leu Asp Lys Asn Gln Ile Ser Cys Ile Glu Glu Gly Ala 
                165                 170                 175     


Phe Arg Ala Leu Arg Gly Leu Glu Val Leu Thr Leu Asn Asn Asn Asn 
            180                 185                 190         


Ile Thr Thr Ile Pro Val Ser Ser Phe Asn His Met Pro Lys Leu Arg 
        195                 200                 205             


Thr Phe Arg Leu His Ser Asn His Leu Phe Cys Asp Cys His Leu Ala 
    210                 215                 220                 


Trp Leu Ser Gln Trp Leu Arg Gln Arg Pro Thr Ile Gly Leu Phe Thr 
225                 230                 235                 240 


Gln Cys Ser Gly Pro Ala Ser Leu Arg Gly Leu Asn Val Ala Glu Val 
                245                 250                 255     


Gln Lys Ser Glu Phe Ser Cys Ser Gly Gln Gly Glu Ala Gly Arg Val 
            260                 265                 270         


Pro Thr Cys Thr Leu Ser Ser Gly Ser Cys Pro Ala Met Cys Thr Cys 
        275                 280                 285             


Ser Asn Gly Ile Val Asp Cys Arg Gly Lys Gly Leu Thr Ala Ile Pro 
    290                 295                 300                 


Ala Asn Leu Pro Glu Thr Met Thr Glu Ile Arg Leu Glu Leu Asn Gly 
305                 310                 315                 320 


Ile Lys Ser Ile Pro Pro Gly Ala Phe Ser Pro Tyr Arg Lys Leu Arg 
                325                 330                 335     


Arg Ile Asp Leu Ser Asn Asn Gln Ile Ala Glu Ile Ala Pro Asp Ala 
            340                 345                 350         


Phe Gln Gly Leu Arg Ser Leu Asn Ser Leu Val Leu Tyr Gly Asn Lys 
        355                 360                 365             


Ile Thr Asp Leu Pro Arg Gly Val Phe Gly Gly Leu Tyr Thr Leu Gln 
    370                 375                 380                 


Leu Leu Leu Leu Asn Ala Asn Lys Ile Asn Cys Ile Arg Pro Asp Ala 
385                 390                 395                 400 


Phe Gln Asp Leu Gln Asn Leu Ser Leu Leu Ser Leu Tyr Asp Asn Lys 
                405                 410                 415     


Ile Gln Ser Leu Ala Lys Gly Thr Phe Thr Ser Leu Arg Ala Ile Gln 
            420                 425                 430         


Thr Leu His Leu Ala Gln Asn Pro Phe Ile Cys Asp Cys Asn Leu Lys 
        435                 440                 445             


Trp Leu Ala Asp Phe Leu Arg Thr Asn Pro Ile Glu Thr Ser Gly Ala 
    450                 455                 460                 


Arg Cys Ala Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile 
465                 470                 475                 480 


Lys Ser Lys Lys Phe Arg Cys Ser Ala Lys Glu Gln Tyr Phe Ile Pro 
                485                 490                 495     


Gly Thr Glu Asp Tyr Gln Leu Asn Ser Glu Cys Asn Ser Asp Val Val 
            500                 505                 510         


Cys Pro His Lys Cys Arg Cys Glu Ala Asn Val Val Glu Cys Ser Ser 
        515                 520                 525             


Leu Lys Leu Thr Lys Ile Pro Glu Arg Ile Pro Gln Ser Thr Ala Glu 
    530                 535                 540                 


Leu Arg Leu Asn Asn Asn Glu Ile Ser Ile Leu Glu Ala Thr Gly Met 
545                 550                 555                 560 


Phe Lys Lys Leu Thr His Leu Lys Lys Ile Asn Leu Ser Asn Asn Lys 
                565                 570                 575     


Val Ser Glu Ile Glu Asp Gly Ala Phe Glu Gly Ala Ala Ser Val Ser 
            580                 585                 590         


Glu Leu His Leu Thr Ala Asn Gln Leu Glu Ser Ile Arg Ser Gly Met 
        595                 600                 605             


Phe Arg Gly Leu Asp Gly Leu Arg Thr Leu Met Leu Arg Asn Asn Arg 
    610                 615                 620                 


Ile Ser Cys Ile His Asn Asp Ser Phe Thr Gly Leu Arg Asn Val Arg 
625                 630                 635                 640 


Leu Leu Ser Leu Tyr Asp Asn Gln Ile Thr Thr Val Ser Pro Gly Ala 
                645                 650                 655     


Phe Asp Thr Leu Gln Ser Leu Ser Thr Leu Asn Leu Leu Ala Asn Pro 
            660                 665                 670         


Phe Asn Cys Asn Cys Gln Leu Ala Trp Leu Gly Gly Trp Leu Arg Lys 
        675                 680                 685             


Arg Lys Ile Val Thr Gly Asn Pro Arg Cys Gln Asn Pro Asp Phe Leu 
    690                 695                 700                 


Arg Gln Ile Pro Leu Gln Asp Val Ala Phe Pro Asp Phe Arg Cys Glu 
705                 710                 715                 720 


Glu Gly Gln Glu Glu Gly Gly Cys Leu Pro Arg Pro Gln Cys Pro Gln 
                725                 730                 735     


Glu Cys Ala Cys Leu Asp Thr Val Val Arg Cys Ser Asn Lys His Leu 
            740                 745                 750         


Arg Ala Leu Pro Lys Gly Ile Pro Lys Asn Val Thr Glu Leu Tyr Leu 
        755                 760                 765             


Asp Gly Asn Gln Phe Thr Leu Val Pro Gly Gln Leu Ser Thr Phe Lys 
    770                 775                 780                 


Tyr Leu Gln Leu Val Asp Leu Ser Asn Asn Lys Ile Ser Ser Leu Ser 
785                 790                 795                 800 


Asn Ser Ser Phe Thr Asn Met Ser Gln Leu Thr Thr Leu Ile Leu Ser 
                805                 810                 815     


Tyr Asn Ala Leu Gln Cys Ile Pro Pro Leu Ala Phe Gln Gly Leu Arg 
            820                 825                 830         


Ser Leu Arg Leu Leu Ser Leu His Gly Asn Asp Ile Ser Thr Leu Gln 
        835                 840                 845             


Glu Gly Ile Phe Ala Asp Val Thr Ser Leu Ser His Leu Ala Ile Gly 
    850                 855                 860                 


Ala Asn Pro Leu Tyr Cys Asp Cys His Leu Arg Trp Leu Ser Ser Trp 
865                 870                 875                 880 


Val Lys Thr Gly Tyr Lys Glu Pro Gly Ile Ala Arg Cys Ala Gly Pro 
                885                 890                 895     


Gln Asp Met Glu Gly Lys Leu Leu Leu Thr Thr Pro Ala Lys Lys Phe 
            900                 905                 910         


Glu Cys Gln Gly Pro Pro Thr Leu Ala Val Gln Ala Lys Cys Asp Leu 
        915                 920                 925             


Cys Leu Ser Ser Pro Cys Gln Asn Gln Gly Thr Cys His Asn Asp Pro 
    930                 935                 940                 


Leu Glu Val Tyr Arg Cys Ala Cys Pro Ser Gly Tyr Lys Gly Arg Asp 
945                 950                 955                 960 


Cys Glu Val Ser Leu Asp Ser Cys Ser Ser Gly Pro Cys Glu Asn Gly 
                965                 970                 975     


Gly Thr Cys His Ala Gln Glu Gly Glu Asp Ala Pro Phe Thr Cys Ser 
            980                 985                 990         


Cys Pro Thr Gly Phe Glu Gly Pro  Thr Cys Gly Val Asn  Thr Asp Asp 
        995                 1000                 1005             


Cys Val  Asp His Ala Cys Ala  Asn Gly Gly Val Cys  Val Asp Gly 
    1010                 1015                 1020             


Val Gly  Asn Tyr Thr Cys Gln  Cys Pro Leu Gln Tyr  Glu Gly Lys 
    1025                 1030                 1035             


Ala Cys  Glu Gln Leu Val Asp  Leu Cys Ser Pro Asp  Leu Asn Pro 
    1040                 1045                 1050             


Cys Gln  His Glu Ala Gln Cys  Val Gly Thr Pro Asp  Gly Pro Arg 
    1055                 1060                 1065             


Cys Glu  Cys Met Pro Gly Tyr  Ala Gly Asp Asn Cys  Ser Glu Asn 
    1070                 1075                 1080             


Gln Asp  Asp Cys Arg Asp His  Arg Cys Gln Asn Gly  Ala Gln Cys 
    1085                 1090                 1095             


Met Asp  Glu Val Asn Ser Tyr  Ser Cys Leu Cys Ala  Glu Gly Tyr 
    1100                 1105                 1110             


Ser Gly  Gln Leu Cys Glu Ile  Pro Pro His Leu Pro  Ala Pro Lys 
    1115                 1120                 1125             


Ser Pro  Cys Glu Gly Thr Glu  Cys Gln Asn Gly Ala  Asn Cys Val 
    1130                 1135                 1140             


Asp Gln  Gly Asn Arg Pro Val  Cys Gln Cys Leu Pro  Gly Phe Gly 
    1145                 1150                 1155             


Gly Pro  Glu Cys Glu Lys Leu  Leu Ser Val Asn Phe  Val Asp Arg 
    1160                 1165                 1170             


Asp Thr  Tyr Leu Gln Phe Thr  Asp Leu Gln Asn Trp  Pro Arg Ala 
    1175                 1180                 1185             


Asn Ile  Thr Leu Gln Val Ser  Thr Ala Glu Asp Asn  Gly Ile Leu 
    1190                 1195                 1200             


Leu Tyr  Asn Gly Asp Asn Asp  His Ile Ala Val Glu  Leu Tyr Gln 
    1205                 1210                 1215             


Gly His  Val Arg Val Ser Tyr  Asp Pro Gly Ser Tyr  Pro Ser Ser 
    1220                 1225                 1230             


Ala Ile  Tyr Ser Ala Glu Thr  Ile Asn Asp Gly Gln  Phe His Thr 
    1235                 1240                 1245             


Val Glu  Leu Val Ala Phe Asp  Gln Met Val Asn Leu  Ser Ile Asp 
    1250                 1255                 1260             


Gly Gly  Ser Pro Met Thr Met  Asp Asn Phe Gly Lys  His Tyr Thr 
    1265                 1270                 1275             


Leu Asn  Ser Glu Ala Pro Leu  Tyr Val Gly Gly Met  Pro Val Asp 
    1280                 1285                 1290             


Val Asn  Ser Ala Ala Phe Arg  Leu Trp Gln Ile Leu  Asn Gly Thr 
    1295                 1300                 1305             


Gly Phe  His Gly Cys Ile Arg  Asn Leu Tyr Ile Asn  Asn Glu Leu 
    1310                 1315                 1320             


Gln Asp  Phe Thr Lys Thr Gln  Met Lys Pro Gly Val  Val Pro Gly 
    1325                 1330                 1335             


Cys Glu  Pro Cys Arg Lys Leu  Tyr Cys Leu His Gly  Ile Cys Gln 
    1340                 1345                 1350             


Pro Asn  Ala Thr Pro Gly Pro  Met Cys His Cys Glu  Ala Gly Trp 
    1355                 1360                 1365             


Val Gly  Leu His Cys Asp Gln  Pro Ala Asp Gly Pro  Cys His Gly 
    1370                 1375                 1380             


His Lys  Cys Val His Gly Gln  Cys Val Pro Leu Asp  Ala Leu Ser 
    1385                 1390                 1395             


Tyr Ser  Cys Gln Cys Gln Asp  Gly Tyr Ser Gly Ala  Leu Cys Asn 
    1400                 1405                 1410             


Gln Ala  Gly Ala Leu Ala Glu  Pro Cys Arg Gly Leu  Gln Cys Leu 
    1415                 1420                 1425             


His Gly  His Cys Gln Ala Ser  Gly Thr Lys Gly Ala  His Cys Val 
    1430                 1435                 1440             


Cys Asp  Pro Gly Phe Ser Gly  Glu Leu Cys Glu Gln  Glu Ser Glu 
    1445                 1450                 1455             


Cys Arg  Gly Asp Pro Val Arg  Asp Phe His Gln Val  Gln Arg Gly 
    1460                 1465                 1470             


Tyr Ala  Ile Cys Gln Thr Thr  Arg Pro Leu Ser Trp  Val Glu Cys 
    1475                 1480                 1485             


Arg Gly  Ser Cys Pro Gly Gln  Gly Cys Cys Gln Gly  Leu Arg Leu 
    1490                 1495                 1500             


Lys Arg  Arg Lys Phe Thr Phe  Glu Cys Ser Asp Gly  Thr Ser Phe 
    1505                 1510                 1515             


Ala Glu  Glu Val Glu Lys Pro  Thr Lys Cys Gly Cys  Ala Leu Cys 
    1520                 1525                 1530             


Ala 
    


<210>  11
<211>  1531
<212>  PRT
<213>  Mus musculus

<400>  11

Met Ala Leu Thr Pro Gln Arg Gly Ser Ser Ser Gly Leu Ser Arg Pro 
1               5                   10                  15      


Glu Leu Trp Leu Leu Leu Trp Ala Ala Ala Trp Arg Leu Gly Ala Thr 
            20                  25                  30          


Ala Cys Pro Ala Leu Cys Thr Cys Thr Gly Thr Thr Val Asp Cys His 
        35                  40                  45              


Gly Thr Gly Leu Gln Ala Ile Pro Lys Asn Ile Pro Arg Asn Thr Glu 
    50                  55                  60                  


Arg Leu Glu Leu Asn Gly Asn Asn Ile Thr Arg Ile His Lys Asn Asp 
65                  70                  75                  80  


Phe Ala Gly Leu Lys Gln Leu Arg Val Leu Gln Leu Met Glu Asn Gln 
                85                  90                  95      


Ile Gly Ala Val Glu Arg Gly Ala Phe Asp Asp Met Lys Glu Leu Glu 
            100                 105                 110         


Arg Leu Arg Leu Asn Arg Asn Gln Leu Gln Val Leu Pro Glu Leu Leu 
        115                 120                 125             


Phe Gln Asn Asn Gln Ala Leu Ser Arg Leu Asp Leu Ser Glu Asn Phe 
    130                 135                 140                 


Leu Gln Ala Val Pro Arg Lys Ala Phe Arg Gly Ala Thr Asp Leu Lys 
145                 150                 155                 160 


Asn Leu Gln Leu Asp Lys Asn Arg Ile Ser Cys Ile Glu Glu Gly Ala 
                165                 170                 175     


Phe Arg Ala Leu Arg Gly Leu Glu Val Leu Thr Leu Asn Asn Asn Asn 
            180                 185                 190         


Ile Thr Thr Ile Pro Val Ser Ser Phe Asn His Met Pro Lys Leu Arg 
        195                 200                 205             


Thr Phe Arg Leu His Ser Asn His Leu Phe Cys Asp Cys His Leu Ala 
    210                 215                 220                 


Trp Leu Ser Gln Trp Leu Arg Gln Arg Pro Thr Ile Gly Leu Phe Thr 
225                 230                 235                 240 


Gln Cys Ser Gly Pro Ala Ser Leu Arg Gly Leu Asn Val Ala Glu Val 
                245                 250                 255     


Gln Lys Gly Glu Phe Ser Cys Ser Gly Gln Gly Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ala Cys Thr Leu Ser Ser Gly Ser Cys Pro Ala Met Cys Ser Cys 
        275                 280                 285             


Ser Ser Gly Ile Val Asp Cys Arg Gly Lys Gly Leu Thr Ala Ile Pro 
    290                 295                 300                 


Ala Asn Leu Pro Glu Thr Met Thr Glu Ile Arg Leu Glu Leu Asn Gly 
305                 310                 315                 320 


Ile Lys Ser Ile Pro Pro Gly Ala Phe Ser Pro Tyr Arg Lys Leu Arg 
                325                 330                 335     


Arg Ile Asp Leu Ser Asn Asn Gln Ile Ala Glu Ile Ala Pro Asp Ala 
            340                 345                 350         


Phe Gln Gly Leu Arg Ser Leu Asn Ser Leu Val Leu Tyr Gly Asn Lys 
        355                 360                 365             


Ile Thr Asp Leu Pro Arg Gly Val Phe Gly Gly Leu Tyr Thr Leu Gln 
    370                 375                 380                 


Leu Leu Leu Leu Asn Ala Asn Lys Ile Asn Cys Ile Arg Pro Asp Ala 
385                 390                 395                 400 


Phe Gln Asp Leu Gln Asn Leu Ser Leu Leu Ser Leu Tyr Asp Asn Lys 
                405                 410                 415     


Ile Gln Ser Leu Ala Lys Gly Thr Phe Thr Ser Leu Arg Ala Ile Gln 
            420                 425                 430         


Thr Leu His Leu Ala Gln Asn Pro Phe Ile Cys Asp Cys Asn Leu Lys 
        435                 440                 445             


Trp Leu Ala Asp Phe Leu Arg Thr Asn Pro Ile Glu Thr Thr Gly Ala 
    450                 455                 460                 


Arg Cys Ala Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile 
465                 470                 475                 480 


Lys Ser Lys Lys Phe Arg Cys Ser Ala Lys Glu Gln Tyr Phe Ile Pro 
                485                 490                 495     


Gly Thr Glu Asp Tyr His Leu Asn Ser Glu Cys Thr Ser Asp Val Ala 
            500                 505                 510         


Cys Pro His Lys Cys Arg Cys Glu Ala Ser Val Val Glu Cys Ser Ser 
        515                 520                 525             


Leu Lys Leu Ser Lys Ile Pro Glu Arg Ile Pro Gln Ser Thr Thr Glu 
    530                 535                 540                 


Leu Arg Leu Asn Asn Asn Glu Ile Ser Ile Leu Glu Ala Thr Gly Leu 
545                 550                 555                 560 


Phe Lys Lys Leu Ser His Leu Lys Lys Ile Asn Leu Ser Asn Asn Lys 
                565                 570                 575     


Val Ser Glu Ile Glu Asp Gly Thr Phe Glu Gly Ala Ala Ser Val Ser 
            580                 585                 590         


Glu Leu His Leu Thr Ala Asn Gln Leu Glu Ser Ile Arg Ser Gly Met 
        595                 600                 605             


Phe Arg Gly Leu Asp Gly Leu Arg Thr Leu Met Leu Arg Asn Asn Arg 
    610                 615                 620                 


Ile Ser Cys Ile His Asn Asp Ser Phe Thr Gly Leu Arg Asn Val Arg 
625                 630                 635                 640 


Leu Leu Ser Leu Tyr Asp Asn His Ile Thr Thr Ile Ser Pro Gly Ala 
                645                 650                 655     


Phe Asp Thr Leu Gln Ala Leu Ser Thr Leu Asn Leu Leu Ala Asn Pro 
            660                 665                 670         


Phe Asn Cys Asn Cys His Leu Ser Trp Leu Gly Asp Trp Leu Arg Lys 
        675                 680                 685             


Arg Lys Ile Val Thr Gly Asn Pro Arg Cys Gln Asn Pro Asp Phe Leu 
    690                 695                 700                 


Arg Gln Ile Pro Leu Gln Asp Val Ala Phe Pro Asp Phe Arg Cys Glu 
705                 710                 715                 720 


Glu Gly Gln Glu Glu Val Gly Cys Leu Pro Arg Pro Gln Cys Pro Gln 
                725                 730                 735     


Glu Cys Ala Cys Leu Asp Thr Val Val Arg Cys Ser Asn Lys His Leu 
            740                 745                 750         


Gln Ala Leu Pro Lys Gly Ile Pro Lys Asn Val Thr Glu Leu Tyr Leu 
        755                 760                 765             


Asp Gly Asn Gln Phe Thr Leu Val Pro Gly Gln Leu Ser Thr Phe Lys 
    770                 775                 780                 


Tyr Leu Gln Leu Val Asp Leu Ser Asn Asn Lys Ile Ser Ser Leu Ser 
785                 790                 795                 800 


Asn Ser Ser Phe Thr Asn Met Ser Gln Leu Thr Thr Leu Ile Leu Ser 
                805                 810                 815     


Tyr Asn Ala Leu Gln Cys Ile Pro Pro Leu Ala Phe Gln Gly Leu Arg 
            820                 825                 830         


Ser Leu Arg Leu Leu Ser Leu His Gly Asn Asp Val Ser Thr Leu Gln 
        835                 840                 845             


Glu Gly Ile Phe Ala Asp Val Thr Ser Leu Ser His Leu Ala Ile Gly 
    850                 855                 860                 


Ala Asn Pro Leu Tyr Cys Asp Cys Arg Leu Arg Trp Leu Ser Ser Trp 
865                 870                 875                 880 


Val Lys Thr Gly Tyr Lys Glu Pro Gly Ile Ala Arg Cys Ala Gly Pro 
                885                 890                 895     


Pro Glu Met Glu Gly Lys Leu Leu Leu Thr Thr Pro Ala Lys Lys Phe 
            900                 905                 910         


Glu Cys Gln Gly Pro Pro Ser Leu Ala Val Gln Ala Lys Cys Asp Pro 
        915                 920                 925             


Cys Leu Ser Ser Pro Cys Gln Asn Gln Gly Thr Cys His Asn Asp Pro 
    930                 935                 940                 


Leu Glu Val Tyr Arg Cys Thr Cys Pro Ser Gly Tyr Lys Gly Arg His 
945                 950                 955                 960 


Cys Glu Val Ser Leu Asp Gly Cys Ser Ser Asn Pro Cys Gly Asn Gly 
                965                 970                 975     


Gly Thr Cys His Ala Gln Glu Gly Glu Asp Ala Gly Phe Thr Cys Ser 
            980                 985                 990         


Cys Pro Ser Gly Phe Glu Gly Pro  Thr Cys Gly Val Asp  Thr Asp Asp 
        995                 1000                 1005             


Cys Val  Lys His Ala Cys Val  Asn Gly Gly Val Cys  Val Asp Gly 
    1010                 1015                 1020             


Val Gly  Asn Tyr Thr Cys Gln  Cys Pro Leu Gln Tyr  Thr Gly Arg 
    1025                 1030                 1035             


Ala Cys  Glu Gln Leu Val Asp  Phe Cys Ser Pro Asp  Met Asn Pro 
    1040                 1045                 1050             


Cys Gln  His Glu Ala Gln Cys  Val Gly Thr Pro Asp  Gly Pro Arg 
    1055                 1060                 1065             


Cys Glu  Cys Met Leu Gly Tyr  Thr Gly Asp Asn Cys  Ser Glu Asn 
    1070                 1075                 1080             


Gln Asp  Asp Cys Lys Asp His  Lys Cys Gln Asn Gly  Ala Gln Cys 
    1085                 1090                 1095             


Val Asp  Glu Val Asn Ser Tyr  Ala Cys Leu Cys Val  Glu Gly Tyr 
    1100                 1105                 1110             


Ser Gly  Gln Leu Cys Glu Ile  Pro Pro Ala Pro Arg  Ser Ser Cys 
    1115                 1120                 1125             


Glu Gly  Thr Glu Cys Gln Asn  Gly Ala Asn Cys Val  Asp Gln Gly 
    1130                 1135                 1140             


Ser Arg  Pro Val Cys Gln Cys  Leu Pro Gly Phe Gly  Gly Pro Glu 
    1145                 1150                 1155             


Cys Glu  Lys Leu Leu Ser Val  Asn Phe Val Asp Arg  Asp Thr Tyr 
    1160                 1165                 1170             


Leu Gln  Phe Thr Asp Leu Gln  Asn Trp Pro Arg Ala  Asn Ile Thr 
    1175                 1180                 1185             


Leu Gln  Val Ser Thr Ala Glu  Asp Asn Gly Ile Leu  Leu Tyr Asn 
    1190                 1195                 1200             


Gly Asp  Asn Asp His Ile Ala  Val Glu Leu Tyr Gln  Gly His Val 
    1205                 1210                 1215             


Arg Val  Ser Tyr Asp Pro Gly  Ser Tyr Pro Ser Ser  Ala Ile Tyr 
    1220                 1225                 1230             


Ser Ala  Glu Thr Ile Asn Asp  Gly Gln Phe His Thr  Val Glu Leu 
    1235                 1240                 1245             


Val Thr  Phe Asp Gln Met Val  Asn Leu Ser Ile Asp  Gly Gly Ser 
    1250                 1255                 1260             


Pro Met  Thr Met Asp Asn Phe  Gly Lys His Tyr Thr  Leu Asn Ser 
    1265                 1270                 1275             


Glu Ala  Pro Leu Tyr Val Gly  Gly Met Pro Val Asp  Val Asn Ser 
    1280                 1285                 1290             


Ala Ala  Phe Arg Leu Trp Gln  Ile Leu Asn Gly Thr  Ser Phe His 
    1295                 1300                 1305             


Gly Cys  Ile Arg Asn Leu Tyr  Ile Asn Asn Glu Leu  Gln Asp Phe 
    1310                 1315                 1320             


Thr Lys  Thr Gln Met Lys Pro  Gly Val Val Pro Gly  Cys Glu Pro 
    1325                 1330                 1335             


Cys Arg  Lys Leu Tyr Cys Leu  His Gly Ile Cys Gln  Pro Asn Ala 
    1340                 1345                 1350             


Thr Pro  Gly Pro Val Cys His  Cys Glu Ala Gly Trp  Gly Gly Leu 
    1355                 1360                 1365             


His Cys  Asp Gln Pro Val Asp  Gly Pro Cys His Gly  His Lys Cys 
    1370                 1375                 1380             


Val His  Gly Lys Cys Val Pro  Leu Asp Ala Leu Ala  Tyr Ser Cys 
    1385                 1390                 1395             


Gln Cys  Gln Asp Gly Tyr Ser  Gly Ala Leu Cys Asn  Gln Val Gly 
    1400                 1405                 1410             


Ala Val  Ala Glu Pro Cys Gly  Gly Leu Gln Cys Leu  His Gly His 
    1415                 1420                 1425             


Cys Gln  Ala Ser Ala Thr Lys  Gly Ala His Cys Val  Cys Ser Pro 
    1430                 1435                 1440             


Gly Phe  Ser Gly Glu Leu Cys  Glu Gln Glu Ser Glu  Cys Arg Gly 
    1445                 1450                 1455             


Asp Pro  Val Arg Asp Phe His  Arg Val Gln Arg Gly  Tyr Ala Ile 
    1460                 1465                 1470             


Cys Gln  Thr Thr Arg Pro Leu  Ser Trp Val Glu Cys  Arg Gly Ala 
    1475                 1480                 1485             


Cys Pro  Gly Gln Gly Cys Cys  Gln Gly Leu Arg Leu  Lys Arg Arg 
    1490                 1495                 1500             


Lys Leu  Thr Phe Glu Cys Ser  Asp Gly Thr Ser Phe  Ala Glu Glu 
    1505                 1510                 1515             


Val Glu  Lys Pro Thr Lys Cys  Gly Cys Ala Gln Cys  Ala 
    1520                 1525                 1530     


<210>  12
<211>  4950
<212>  DNA
<213>  Homo sapiens

<400>  12
cagagcaggg tggagagggc ggtgggaggc gtgtgcctga gtgggctcta ctgccttgtt       60

ccatattatt ttgtgcacat tttccctggc actctgggtt gctagccccg ccgggcactg      120

ggcctcagac actgcgcggt tccctcggag cagcaagcta aagaaagccc ccagtgccgg      180

cgaggaagga ggcggcgggg aaagatgcgc ggcgttggct ggcagatgct gtccctgtcg      240

ctggggttag tgctggcgat cctgaacaag gtggcaccgc aggcgtgccc ggcgcagtgc      300

tcttgctcgg gcagcacagt ggactgtcac gggctggcgc tgcgcagcgt gcccaggaat      360

atcccccgca acaccgagag actggattta aatggaaata acatcacaag aattacgaag      420

acagattttg ctggtcttag acatctaaga gttcttcagc ttatggagaa taagattagc      480

accattgaaa gaggagcatt ccaggatctt aaagaactag agagactgcg tttaaacaga      540

aatcaccttc agctgtttcc tgagttgctg tttcttggga ctgcgaagct atacaggctt      600

gatctcagtg aaaaccaaat tcaggcaatc ccaaggaaag ctttccgtgg ggcagttgac      660

ataaaaaatt tgcaactgga ttacaaccag atcagctgta ttgaagatgg ggcattcagg      720

gctctccggg acctggaagt gctcactctc aacaataaca acattactag actttctgtg      780

gcaagtttca accatatgcc taaacttagg acttttcgac tgcattcaaa caacctgtat      840

tgtgactgcc acctggcctg gctctccgac tggcttcgcc aaaggcctcg ggttggtctg      900

tacactcagt gtatgggccc ctcccacctg agaggccata atgtagccga ggttcaaaaa      960

cgagaatttg tctgcagtgg tcaccagtca tttatggctc cttcttgtag tgttttgcac     1020

tgccctgccg cctgtacctg tagcaacaat atcgtagact gtcgtgggaa aggtctcact     1080

gagatcccca caaatcttcc agagaccatc acagaaatac gtttggaaca gaacacaatc     1140

aaagtcatcc ctcctggagc tttctcacca tataaaaagc ttagacgaat tgacctgagc     1200

aataatcaga tctctgaact tgcaccagat gctttccaag gactacgctc tctgaattca     1260

cttgtcctct atggaaataa aatcacagaa ctccccaaaa gtttatttga aggactgttt     1320

tccttacagc tcctattatt gaatgccaac aagataaact gccttcgggt agatgctttt     1380

caggatctcc acaacttgaa ccttctctcc ctatatgaca acaagcttca gaccatcgcc     1440

aaggggacct tttcacctct tcgggccatt caaactatgc atttggccca gaaccccttt     1500

atttgtgact gccatctcaa gtggctagcg gattatctcc ataccaaccc gattgagacc     1560

agtggtgccc gttgcaccag cccccgccgc ctggcaaaca aaagaattgg acagatcaaa     1620

agcaagaaat tccgttgttc agctaaagaa cagtatttca ttccaggtac agaagattat     1680

cgatcaaaat taagtggaga ctgctttgcg gatctggctt gccctgaaaa gtgtcgctgt     1740

gaaggaacca cagtagattg ctctaatcaa aagctcaaca aaatcccgga gcacattccc     1800

cagtacactg cagagttgcg tctcaataat aatgaattta ccgtgttgga agccacagga     1860

atctttaaga aacttcctca attacgtaaa ataaacttta gcaacaataa gatcacagat     1920

attgaggagg gagcatttga aggagcatct ggtgtaaatg aaatacttct tacgagtaat     1980

cgtttggaaa atgtgcagca taagatgttc aagggattgg aaagcctcaa aactttgatg     2040

ttgagaagca atcgaataac ctgtgtgggg aatgacagtt tcataggact cagttctgtg     2100

cgtttgcttt ctttgtatga taatcaaatt actacagttg caccaggggc atttgatact     2160

ctccattctt tatctactct aaacctcttg gccaatcctt ttaactgtaa ctgctacctg     2220

gcttggttgg gagagtggct gagaaagaag agaattgtca cgggaaatcc tagatgtcaa     2280

aaaccatact tcctgaaaga aatacccatc caggatgtgg ccattcagga cttcacttgt     2340

gatgacggaa atgatgacaa tagttgctcc ccactttctc gctgtcctac tgaatgtact     2400

tgcttggata cagtcgtccg atgtagcaac aagggtttga aggtcttgcc gaaaggtatt     2460

ccaagagatg tcacagagtt gtatctggat ggaaaccaat ttacactggt tcccaaggaa     2520

ctctccaact acaaacattt aacacttata gacttaagta acaacagaat aagcacgctt     2580

tctaatcaga gcttcagcaa catgacccag ctcctcacct taattcttag ttacaaccgt     2640

ctgagatgta ttcctcctcg cacctttgat ggattaaagt ctcttcgatt actttctcta     2700

catggaaatg acatttctgt tgtgcctgaa ggtgctttca atgatctttc tgcattatca     2760

catctagcaa ttggagccaa ccctctttac tgtgattgta acatgcagtg gttatccgac     2820

tgggtgaagt cggaatataa ggagcctgga attgctcgtt gtgctggtcc tggagaaatg     2880

gcagataaac ttttactcac aactccctcc aaaaaattta cctgtcaagg tcctgtggat     2940

gtcaatattc tagctaagtg taacccctgc ctatcaaatc cgtgtaaaaa tgatggcaca     3000

tgtaatagtg atccagttga cttttaccga tgcacctgtc catatggttt caaggggcag     3060

gactgtgatg tcccaattca tgcctgcatc agtaacccat gtaaacatgg aggaacttgc     3120

cacttaaagg aaggagaaga agatggattc tggtgtattt gtgctgatgg atttgaagga     3180

gaaaattgtg aagtcaacgt tgatgattgt gaagataatg actgtgaaaa taattctaca     3240

tgtgtcgatg gcattaataa ctacacatgc ctttgcccac ctgagtatac aggtgagttg     3300

tgtgaggaga agctggactt ctgtgcccag gacctgaacc cctgccagca cgattcaaag     3360

tgcatcctaa ctccaaaggg attcaaatgt gactgcacac cagggtacgt aggtgaacac     3420

tgcgacatcg attttgacga ctgccaagac aacaagtgta aaaacggagc ccactgcaca     3480

gatgcagtga acggctatac gtgcatatgc cccgaaggtt acagtggctt gttctgtgag     3540

ttttctccac ccatggtcct ccctcgtacc agcccctgtg ataattttga ttgtcagaat     3600

ggagctcagt gtatcgtcag aataaatgag ccaatatgtc agtgtttgcc tggctatcag     3660

ggagaaaagt gtgaaaaatt ggttagtgtg aattttataa acaaagagtc ttatcttcag     3720

attccttcag ccaaggttcg gcctcagacg aacataacac ttcagattgc cacagatgaa     3780

gacagcggaa tcctcctgta taagggtgac aaagaccata tcgcggtaga actctatcgg     3840

gggcgtgttc gtgccagcta tgacaccggc tctcatccag cttctgccat ttacagtgtg     3900

gagacaatca atgatggaaa cttccacatt gtggaactac ttgccttgga tcagagtctc     3960

tctttgtccg tggatggtgg gaaccccaaa atcatcacta acttgtcaaa gcagtccact     4020

ctgaattttg actctccact ctatgtagga ggcatgccag ggaagagtaa cgtggcatct     4080

ctgcgccagg cccctgggca gaacggaacc agcttccacg gctgcatccg gaacctttac     4140

atcaacagtg agctgcagga cttccagaag gtgccgatgc aaacaggcat tttgcctggc     4200

tgtgagccat gccacaagaa ggtgtgtgcc catggcacat gccagcccag cagccaggca     4260

ggcttcacct gcgagtgcca ggaaggatgg atggggcccc tctgtgacca acggaccaat     4320

gacccttgcc ttggaaataa atgcgtacat ggcacctgct tgcccatcaa tgcgttctcc     4380

tacagctgta agtgcttgga gggccatgga ggtgtcctct gtgatgaaga ggaggatctg     4440

tttaacccat gccaggcgat caagtgcaag cacgggaagt gcaggctttc aggtctgggg     4500

cagccctact gtgaatgcag cagtggatac acgggggaca gctgtgatcg agaaatctct     4560

tgtcgagggg aaaggataag agattattac caaaagcagc agggctatgc tgcttgccaa     4620

acaaccaaga aggtgtcccg attagagtgc agaggtgggt gtgcaggagg gcagtgctgt     4680

ggaccgctga ggagcaagcg gcggaaatac tctttcgaat gcactgacgg ctcctccttt     4740

gtggacgagg ttgagaaagt ggtgaagtgc ggctgtacga ggtgtgtgtc ctaaacacac     4800

tcccggcagc tctgtctttg gaaaaggttg tatacttctt gaccatgtgg gactaatgaa     4860

tgcttcatag tggaaatatt tgaaatatat tgtaaaatac agaacagact tatttttatt     4920

atgagaataa agactttttt tctgcatttg                                      4950


<210>  13
<211>  1529
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Arg Gly Val Gly Trp Gln Met Leu Ser Leu Ser Leu Gly Leu Val 
1               5                   10                  15      


Leu Ala Ile Leu Asn Lys Val Ala Pro Gln Ala Cys Pro Ala Gln Cys 
            20                  25                  30          


Ser Cys Ser Gly Ser Thr Val Asp Cys His Gly Leu Ala Leu Arg Ser 
        35                  40                  45              


Val Pro Arg Asn Ile Pro Arg Asn Thr Glu Arg Leu Asp Leu Asn Gly 
    50                  55                  60                  


Asn Asn Ile Thr Arg Ile Thr Lys Thr Asp Phe Ala Gly Leu Arg His 
65                  70                  75                  80  


Leu Arg Val Leu Gln Leu Met Glu Asn Lys Ile Ser Thr Ile Glu Arg 
                85                  90                  95      


Gly Ala Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn Arg 
            100                 105                 110         


Asn His Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly Thr Ala Lys 
        115                 120                 125             


Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile Gln Ala Ile Pro Arg 
    130                 135                 140                 


Lys Ala Phe Arg Gly Ala Val Asp Ile Lys Asn Leu Gln Leu Asp Tyr 
145                 150                 155                 160 


Asn Gln Ile Ser Cys Ile Glu Asp Gly Ala Phe Arg Ala Leu Arg Asp 
                165                 170                 175     


Leu Glu Val Leu Thr Leu Asn Asn Asn Asn Ile Thr Arg Leu Ser Val 
            180                 185                 190         


Ala Ser Phe Asn His Met Pro Lys Leu Arg Thr Phe Arg Leu His Ser 
        195                 200                 205             


Asn Asn Leu Tyr Cys Asp Cys His Leu Ala Trp Leu Ser Asp Trp Leu 
    210                 215                 220                 


Arg Gln Arg Pro Arg Val Gly Leu Tyr Thr Gln Cys Met Gly Pro Ser 
225                 230                 235                 240 


His Leu Arg Gly His Asn Val Ala Glu Val Gln Lys Arg Glu Phe Val 
                245                 250                 255     


Cys Ser Gly His Gln Ser Phe Met Ala Pro Ser Cys Ser Val Leu His 
            260                 265                 270         


Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
        275                 280                 285             


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
    290                 295                 300                 


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
305                 310                 315                 320 


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
                325                 330                 335     


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
            340                 345                 350         


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
        355                 360                 365             


Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile 
    370                 375                 380                 


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Leu 
385                 390                 395                 400 


Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
                405                 410                 415     


Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala Gln Asn Pro Phe 
            420                 425                 430         


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Thr Asn 
        435                 440                 445             


Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser Pro Arg Arg Leu Ala 
    450                 455                 460                 


Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe Arg Cys Ser Ala 
465                 470                 475                 480 


Lys Glu Gln Tyr Phe Ile Pro Gly Thr Glu Asp Tyr Arg Ser Lys Leu 
                485                 490                 495     


Ser Gly Asp Cys Phe Ala Asp Leu Ala Cys Pro Glu Lys Cys Arg Cys 
            500                 505                 510         


Glu Gly Thr Thr Val Asp Cys Ser Asn Gln Lys Leu Asn Lys Ile Pro 
        515                 520                 525             


Glu His Ile Pro Gln Tyr Thr Ala Glu Leu Arg Leu Asn Asn Asn Glu 
    530                 535                 540                 


Phe Thr Val Leu Glu Ala Thr Gly Ile Phe Lys Lys Leu Pro Gln Leu 
545                 550                 555                 560 


Arg Lys Ile Asn Phe Ser Asn Asn Lys Ile Thr Asp Ile Glu Glu Gly 
                565                 570                 575     


Ala Phe Glu Gly Ala Ser Gly Val Asn Glu Ile Leu Leu Thr Ser Asn 
            580                 585                 590         


Arg Leu Glu Asn Val Gln His Lys Met Phe Lys Gly Leu Glu Ser Leu 
        595                 600                 605             


Lys Thr Leu Met Leu Arg Ser Asn Arg Ile Thr Cys Val Gly Asn Asp 
    610                 615                 620                 


Ser Phe Ile Gly Leu Ser Ser Val Arg Leu Leu Ser Leu Tyr Asp Asn 
625                 630                 635                 640 


Gln Ile Thr Thr Val Ala Pro Gly Ala Phe Asp Thr Leu His Ser Leu 
                645                 650                 655     


Ser Thr Leu Asn Leu Leu Ala Asn Pro Phe Asn Cys Asn Cys Tyr Leu 
            660                 665                 670         


Ala Trp Leu Gly Glu Trp Leu Arg Lys Lys Arg Ile Val Thr Gly Asn 
        675                 680                 685             


Pro Arg Cys Gln Lys Pro Tyr Phe Leu Lys Glu Ile Pro Ile Gln Asp 
    690                 695                 700                 


Val Ala Ile Gln Asp Phe Thr Cys Asp Asp Gly Asn Asp Asp Asn Ser 
705                 710                 715                 720 


Cys Ser Pro Leu Ser Arg Cys Pro Thr Glu Cys Thr Cys Leu Asp Thr 
                725                 730                 735     


Val Val Arg Cys Ser Asn Lys Gly Leu Lys Val Leu Pro Lys Gly Ile 
            740                 745                 750         


Pro Arg Asp Val Thr Glu Leu Tyr Leu Asp Gly Asn Gln Phe Thr Leu 
        755                 760                 765             


Val Pro Lys Glu Leu Ser Asn Tyr Lys His Leu Thr Leu Ile Asp Leu 
    770                 775                 780                 


Ser Asn Asn Arg Ile Ser Thr Leu Ser Asn Gln Ser Phe Ser Asn Met 
785                 790                 795                 800 


Thr Gln Leu Leu Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg Cys Ile 
                805                 810                 815     


Pro Pro Arg Thr Phe Asp Gly Leu Lys Ser Leu Arg Leu Leu Ser Leu 
            820                 825                 830         


His Gly Asn Asp Ile Ser Val Val Pro Glu Gly Ala Phe Asn Asp Leu 
        835                 840                 845             


Ser Ala Leu Ser His Leu Ala Ile Gly Ala Asn Pro Leu Tyr Cys Asp 
    850                 855                 860                 


Cys Asn Met Gln Trp Leu Ser Asp Trp Val Lys Ser Glu Tyr Lys Glu 
865                 870                 875                 880 


Pro Gly Ile Ala Arg Cys Ala Gly Pro Gly Glu Met Ala Asp Lys Leu 
                885                 890                 895     


Leu Leu Thr Thr Pro Ser Lys Lys Phe Thr Cys Gln Gly Pro Val Asp 
            900                 905                 910         


Val Asn Ile Leu Ala Lys Cys Asn Pro Cys Leu Ser Asn Pro Cys Lys 
        915                 920                 925             


Asn Asp Gly Thr Cys Asn Ser Asp Pro Val Asp Phe Tyr Arg Cys Thr 
    930                 935                 940                 


Cys Pro Tyr Gly Phe Lys Gly Gln Asp Cys Asp Val Pro Ile His Ala 
945                 950                 955                 960 


Cys Ile Ser Asn Pro Cys Lys His Gly Gly Thr Cys His Leu Lys Glu 
                965                 970                 975     


Gly Glu Glu Asp Gly Phe Trp Cys Ile Cys Ala Asp Gly Phe Glu Gly 
            980                 985                 990         


Glu Asn Cys Glu Val Asn Val Asp  Asp Cys Glu Asp Asn  Asp Cys Glu 
        995                 1000                 1005             


Asn Asn  Ser Thr Cys Val Asp  Gly Ile Asn Asn Tyr  Thr Cys Leu 
    1010                 1015                 1020             


Cys Pro  Pro Glu Tyr Thr Gly  Glu Leu Cys Glu Glu  Lys Leu Asp 
    1025                 1030                 1035             


Phe Cys  Ala Gln Asp Leu Asn  Pro Cys Gln His Asp  Ser Lys Cys 
    1040                 1045                 1050             


Ile Leu  Thr Pro Lys Gly Phe  Lys Cys Asp Cys Thr  Pro Gly Tyr 
    1055                 1060                 1065             


Val Gly  Glu His Cys Asp Ile  Asp Phe Asp Asp Cys  Gln Asp Asn 
    1070                 1075                 1080             


Lys Cys  Lys Asn Gly Ala His  Cys Thr Asp Ala Val  Asn Gly Tyr 
    1085                 1090                 1095             


Thr Cys  Ile Cys Pro Glu Gly  Tyr Ser Gly Leu Phe  Cys Glu Phe 
    1100                 1105                 1110             


Ser Pro  Pro Met Val Leu Pro  Arg Thr Ser Pro Cys  Asp Asn Phe 
    1115                 1120                 1125             


Asp Cys  Gln Asn Gly Ala Gln  Cys Ile Val Arg Ile  Asn Glu Pro 
    1130                 1135                 1140             


Ile Cys  Gln Cys Leu Pro Gly  Tyr Gln Gly Glu Lys  Cys Glu Lys 
    1145                 1150                 1155             


Leu Val  Ser Val Asn Phe Ile  Asn Lys Glu Ser Tyr  Leu Gln Ile 
    1160                 1165                 1170             


Pro Ser  Ala Lys Val Arg Pro  Gln Thr Asn Ile Thr  Leu Gln Ile 
    1175                 1180                 1185             


Ala Thr  Asp Glu Asp Ser Gly  Ile Leu Leu Tyr Lys  Gly Asp Lys 
    1190                 1195                 1200             


Asp His  Ile Ala Val Glu Leu  Tyr Arg Gly Arg Val  Arg Ala Ser 
    1205                 1210                 1215             


Tyr Asp  Thr Gly Ser His Pro  Ala Ser Ala Ile Tyr  Ser Val Glu 
    1220                 1225                 1230             


Thr Ile  Asn Asp Gly Asn Phe  His Ile Val Glu Leu  Leu Ala Leu 
    1235                 1240                 1245             


Asp Gln  Ser Leu Ser Leu Ser  Val Asp Gly Gly Asn  Pro Lys Ile 
    1250                 1255                 1260             


Ile Thr  Asn Leu Ser Lys Gln  Ser Thr Leu Asn Phe  Asp Ser Pro 
    1265                 1270                 1275             


Leu Tyr  Val Gly Gly Met Pro  Gly Lys Ser Asn Val  Ala Ser Leu 
    1280                 1285                 1290             


Arg Gln  Ala Pro Gly Gln Asn  Gly Thr Ser Phe His  Gly Cys Ile 
    1295                 1300                 1305             


Arg Asn  Leu Tyr Ile Asn Ser  Glu Leu Gln Asp Phe  Gln Lys Val 
    1310                 1315                 1320             


Pro Met  Gln Thr Gly Ile Leu  Pro Gly Cys Glu Pro  Cys His Lys 
    1325                 1330                 1335             


Lys Val  Cys Ala His Gly Thr  Cys Gln Pro Ser Ser  Gln Ala Gly 
    1340                 1345                 1350             


Phe Thr  Cys Glu Cys Gln Glu  Gly Trp Met Gly Pro  Leu Cys Asp 
    1355                 1360                 1365             


Gln Arg  Thr Asn Asp Pro Cys  Leu Gly Asn Lys Cys  Val His Gly 
    1370                 1375                 1380             


Thr Cys  Leu Pro Ile Asn Ala  Phe Ser Tyr Ser Cys  Lys Cys Leu 
    1385                 1390                 1395             


Glu Gly  His Gly Gly Val Leu  Cys Asp Glu Glu Glu  Asp Leu Phe 
    1400                 1405                 1410             


Asn Pro  Cys Gln Ala Ile Lys  Cys Lys His Gly Lys  Cys Arg Leu 
    1415                 1420                 1425             


Ser Gly  Leu Gly Gln Pro Tyr  Cys Glu Cys Ser Ser  Gly Tyr Thr 
    1430                 1435                 1440             


Gly Asp  Ser Cys Asp Arg Glu  Ile Ser Cys Arg Gly  Glu Arg Ile 
    1445                 1450                 1455             


Arg Asp  Tyr Tyr Gln Lys Gln  Gln Gly Tyr Ala Ala  Cys Gln Thr 
    1460                 1465                 1470             


Thr Lys  Lys Val Ser Arg Leu  Glu Cys Arg Gly Gly  Cys Ala Gly 
    1475                 1480                 1485             


Gly Gln  Cys Cys Gly Pro Leu  Arg Ser Lys Arg Arg  Lys Tyr Ser 
    1490                 1495                 1500             


Phe Glu  Cys Thr Asp Gly Ser  Ser Phe Val Asp Glu  Val Glu Lys 
    1505                 1510                 1515             


Val Val  Lys Cys Gly Cys Thr  Arg Cys Val Ser 
    1520                 1525                 


<210>  14
<211>  1521
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ser Gly Ile Gly Trp Gln Thr Leu Ser Leu Ser Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ile Leu Asn Lys Val Ala Pro Gln Ala Cys Pro Ala Gln Cys 
            20                  25                  30          


Ser Cys Ser Gly Ser Thr Val Asp Cys His Gly Leu Ala Leu Arg Ser 
        35                  40                  45              


Val Pro Arg Asn Ile Pro Arg Asn Thr Glu Arg Leu Asp Leu Asn Gly 
    50                  55                  60                  


Asn Asn Ile Thr Arg Ile Thr Lys Ile Asp Phe Ala Gly Leu Arg His 
65                  70                  75                  80  


Leu Arg Val Leu Gln Leu Met Glu Asn Arg Ile Ser Thr Ile Glu Arg 
                85                  90                  95      


Gly Ala Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn Arg 
            100                 105                 110         


Asn Asn Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly Thr Ala Lys 
        115                 120                 125             


Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile Gln Ala Ile Pro Arg 
    130                 135                 140                 


Lys Ala Phe Arg Gly Ala Val Asp Ile Lys Asn Leu Gln Leu Asp Tyr 
145                 150                 155                 160 


Asn Gln Ile Ser Cys Ile Glu Asp Gly Ala Phe Arg Ala Leu Arg Asp 
                165                 170                 175     


Leu Glu Val Leu Thr Leu Asn Asn Asn Asn Ile Thr Arg Leu Ser Val 
            180                 185                 190         


Ala Ser Phe Asn His Met Pro Lys Leu Arg Thr Phe Arg Leu His Ser 
        195                 200                 205             


Asn Asn Leu Tyr Cys Asp Cys His Leu Ala Trp Leu Ser Asp Trp Leu 
    210                 215                 220                 


Arg Gln Arg Pro Arg Val Gly Leu Tyr Thr Gln Cys Met Gly Pro Ser 
225                 230                 235                 240 


His Leu Arg Gly His Asn Val Ala Glu Val Gln Lys Arg Glu Phe Val 
                245                 250                 255     


Cys Ser Gly His Gln Ser Phe Met Ala Pro Ser Cys Ser Val Leu His 
            260                 265                 270         


Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
        275                 280                 285             


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
    290                 295                 300                 


Ile Arg Leu Glu Gln Asn Ser Ile Arg Val Ile Pro Pro Gly Ala Phe 
305                 310                 315                 320 


Ser Pro Tyr Lys Lys Leu Arg Arg Leu Asp Leu Ser Asn Asn Gln Ile 
                325                 330                 335     


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
            340                 345                 350         


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
        355                 360                 365             


Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile 
    370                 375                 380                 


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Leu 
385                 390                 395                 400 


Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Val Ala Lys Gly Thr Phe 
                405                 410                 415     


Ser Ala Leu Arg Ala Ile Gln Thr Met His Leu Ala Gln Asn Pro Phe 
            420                 425                 430         


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Thr Asn 
        435                 440                 445             


Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser Pro Arg Arg Leu Ala 
    450                 455                 460                 


Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe Arg Cys Ser Gly 
465                 470                 475                 480 


Thr Glu Asp Tyr Arg Ser Lys Leu Ser Gly Asp Cys Phe Ala Asp Leu 
                485                 490                 495     


Ala Cys Pro Glu Lys Cys Arg Cys Glu Gly Thr Thr Val Asp Cys Ser 
            500                 505                 510         


Asn Gln Arg Leu Asn Lys Ile Pro Asp His Ile Pro Gln Tyr Thr Ala 
        515                 520                 525             


Glu Leu Arg Leu Asn Asn Asn Glu Phe Thr Val Leu Glu Ala Thr Gly 
    530                 535                 540                 


Ile Phe Lys Lys Leu Pro Gln Leu Arg Lys Ile Asn Phe Ser Asn Asn 
545                 550                 555                 560 


Lys Ile Thr Asp Ile Glu Glu Gly Ala Phe Glu Gly Ala Ser Gly Val 
                565                 570                 575     


Asn Glu Ile Leu Leu Thr Ser Asn Arg Leu Glu Asn Val Gln His Lys 
            580                 585                 590         


Met Phe Lys Gly Leu Glu Ser Leu Lys Thr Leu Met Leu Arg Ser Asn 
        595                 600                 605             


Arg Ile Ser Cys Val Gly Asn Asp Ser Phe Ile Gly Leu Gly Ser Val 
    610                 615                 620                 


Arg Leu Leu Ser Leu Tyr Asp Asn Gln Ile Thr Thr Val Ala Pro Gly 
625                 630                 635                 640 


Ala Phe Asp Ser Leu His Ser Leu Ser Thr Leu Asn Leu Leu Ala Asn 
                645                 650                 655     


Pro Phe Asn Cys Asn Cys His Leu Ala Trp Leu Gly Glu Trp Leu Arg 
            660                 665                 670         


Arg Lys Arg Ile Val Thr Gly Asn Pro Arg Cys Gln Lys Pro Tyr Phe 
        675                 680                 685             


Leu Lys Glu Ile Pro Ile Gln Asp Val Ala Ile Gln Asp Phe Thr Cys 
    690                 695                 700                 


Asp Asp Gly Asn Asp Asp Asn Ser Cys Ser Pro Leu Ser Arg Cys Pro 
705                 710                 715                 720 


Ser Glu Cys Thr Cys Leu Asp Thr Val Val Arg Cys Ser Asn Lys Gly 
                725                 730                 735     


Leu Lys Val Leu Pro Lys Gly Ile Pro Lys Asp Val Thr Glu Leu Tyr 
            740                 745                 750         


Leu Asp Gly Asn Gln Phe Thr Leu Val Pro Lys Glu Leu Ser Asn Tyr 
        755                 760                 765             


Lys His Leu Thr Leu Ile Asp Leu Ser Asn Asn Arg Ile Ser Thr Leu 
    770                 775                 780                 


Ser Asn Gln Ser Phe Ser Asn Met Thr Gln Leu Leu Thr Leu Ile Leu 
785                 790                 795                 800 


Ser Tyr Asn Arg Leu Arg Cys Ile Pro Pro Arg Thr Phe Asp Gly Leu 
                805                 810                 815     


Lys Ser Leu Arg Leu Leu Ser Leu His Gly Asn Asp Ile Ser Val Val 
            820                 825                 830         


Pro Glu Gly Ala Phe Asn Asp Leu Ser Ala Leu Ser His Leu Ala Ile 
        835                 840                 845             


Gly Ala Asn Pro Leu Tyr Cys Asp Cys Asn Met Gln Trp Leu Ser Asp 
    850                 855                 860                 


Trp Val Lys Ser Glu Tyr Lys Glu Pro Gly Ile Ala Arg Cys Ala Gly 
865                 870                 875                 880 


Pro Gly Glu Met Ala Asp Lys Leu Leu Leu Thr Thr Pro Ser Lys Lys 
                885                 890                 895     


Phe Thr Cys Gln Gly Pro Val Asp Ile Thr Ile Gln Ala Lys Cys Asn 
            900                 905                 910         


Pro Cys Leu Ser Asn Pro Cys Lys Asn Asp Gly Thr Cys Asn Asn Asp 
        915                 920                 925             


Pro Val Asp Phe Tyr Arg Cys Thr Cys Pro Tyr Gly Phe Lys Gly Gln 
    930                 935                 940                 


Asp Cys Asp Val Pro Ile His Ala Cys Ile Ser Asn Pro Cys Lys His 
945                 950                 955                 960 


Gly Gly Thr Cys His Leu Lys Glu Gly Glu Asn Ala Gly Phe Trp Cys 
                965                 970                 975     


Thr Cys Ala Asp Gly Phe Glu Gly Glu Asn Cys Glu Val Asn Ile Asp 
            980                 985                 990         


Asp Cys Glu Asp Asn Asp Cys Glu  Asn Asn Ser Thr Cys  Val Asp Gly 
        995                 1000                 1005             


Ile Asn  Asn Tyr Thr Cys Leu  Cys Pro Pro Glu Tyr  Thr Gly Glu 
    1010                 1015                 1020             


Leu Cys  Glu Glu Lys Leu Asp  Phe Cys Ala Gln Asp  Leu Asn Pro 
    1025                 1030                 1035             


Cys Gln  His Asp Ser Lys Cys  Ile Leu Thr Pro Lys  Gly Phe Lys 
    1040                 1045                 1050             


Cys Asp  Cys Thr Pro Gly Tyr  Ile Gly Glu His Cys  Asp Ile Asp 
    1055                 1060                 1065             


Phe Asp  Asp Cys Gln Asp Asn  Lys Cys Lys Asn Gly  Ala His Cys 
    1070                 1075                 1080             


Thr Asp  Ala Val Asn Gly Tyr  Thr Cys Val Cys Pro  Glu Gly Tyr 
    1085                 1090                 1095             


Ser Gly  Leu Phe Cys Glu Phe  Ser Pro Pro Met Val  Leu Pro Arg 
    1100                 1105                 1110             


Thr Ser  Pro Cys Asp Asn Phe  Asp Cys Gln Asn Gly  Ala Gln Cys 
    1115                 1120                 1125             


Ile Ile  Arg Ile Asn Glu Pro  Ile Cys Gln Cys Leu  Pro Gly Tyr 
    1130                 1135                 1140             


Leu Gly  Glu Lys Cys Glu Lys  Leu Val Ser Val Asn  Phe Val Asn 
    1145                 1150                 1155             


Lys Glu  Ser Tyr Leu Gln Ile  Pro Ser Ala Lys Val  Arg Pro Gln 
    1160                 1165                 1170             


Thr Asn  Ile Thr Leu Gln Ile  Ala Thr Asp Glu Asp  Ser Gly Ile 
    1175                 1180                 1185             


Leu Leu  Tyr Lys Gly Asp Lys  Asp His Ile Ala Val  Glu Leu Tyr 
    1190                 1195                 1200             


Arg Gly  Arg Val Arg Ala Ser  Tyr Asp Thr Gly Ser  His Pro Ala 
    1205                 1210                 1215             


Ser Ala  Ile Tyr Ser Val Glu  Thr Ile Asn Asp Gly  Asn Phe His 
    1220                 1225                 1230             


Ile Val  Glu Leu Leu Thr Leu  Asp Ser Ser Leu Ser  Leu Ser Val 
    1235                 1240                 1245             


Asp Gly  Gly Ser Pro Lys Val  Ile Thr Asn Leu Ser  Lys Gln Ser 
    1250                 1255                 1260             


Thr Leu  Asn Phe Asp Ser Pro  Leu Tyr Val Gly Gly  Met Pro Gly 
    1265                 1270                 1275             


Lys Asn  Asn Val Ala Ser Leu  Arg Gln Ala Pro Gly  Gln Asn Gly 
    1280                 1285                 1290             


Thr Ser  Phe His Gly Cys Ile  Arg Asn Leu Tyr Ile  Asn Ser Glu 
    1295                 1300                 1305             


Leu Gln  Asp Phe Arg Lys Met  Pro Met Gln Thr Gly  Ile Leu Pro 
    1310                 1315                 1320             


Gly Cys  Glu Pro Cys His Lys  Lys Val Cys Ala His  Gly Met Cys 
    1325                 1330                 1335             


Gln Pro  Ser Ser Gln Ser Gly  Phe Thr Cys Glu Cys  Glu Glu Gly 
    1340                 1345                 1350             


Trp Met  Gly Pro Leu Cys Asp  Gln Arg Thr Asn Asp  Pro Cys Leu 
    1355                 1360                 1365             


Gly Asn  Lys Cys Val His Gly  Thr Cys Leu Pro Ile  Asn Ala Phe 
    1370                 1375                 1380             


Ser Tyr  Ser Cys Lys Cys Leu  Glu Gly His Gly Gly  Val Leu Cys 
    1385                 1390                 1395             


Asp Glu  Glu Glu Asp Leu Phe  Asn Pro Cys Gln Met  Ile Lys Cys 
    1400                 1405                 1410             


Lys His  Gly Lys Cys Arg Leu  Ser Gly Val Gly Gln  Pro Tyr Cys 
    1415                 1420                 1425             


Glu Cys  Asn Ser Gly Phe Thr  Gly Asp Ser Cys Asp  Arg Glu Ile 
    1430                 1435                 1440             


Ser Cys  Arg Gly Glu Arg Ile  Arg Asp Tyr Tyr Gln  Lys Gln Gln 
    1445                 1450                 1455             


Gly Tyr  Ala Ala Cys Gln Thr  Thr Lys Lys Val Ser  Arg Leu Glu 
    1460                 1465                 1470             


Cys Arg  Gly Gly Cys Ala Gly  Gly Gln Cys Cys Gly  Pro Leu Arg 
    1475                 1480                 1485             


Ser Lys  Arg Arg Lys Tyr Ser  Phe Glu Cys Thr Asp  Gly Ser Ser 
    1490                 1495                 1500             


Phe Val  Asp Glu Val Glu Lys  Val Val Lys Cys Gly  Cys Ala Arg 
    1505                 1510                 1515             


Cys Ala  Ser 
    1520     


<210>  15
<211>  9727
<212>  DNA
<213>  Homo sapiens

<400>  15
gagagcgagc gccggccagc tcacccggcc gccccgtgcc ccagccgcag ccgccgcgct       60

ccccagccca gccccaagcc ggacctcccc gggcgccacg ccccattgcg ctcgccccag      120

gtccccaacc cggcccgcgg gccagcgggg ccagggggcg ctccgcacct gggcactccc      180

agcgatgcgc agcggggcag cgccggcccc gccgatggag ctgctgttgc tgccgccgcc      240

gccgcccgga gcgccccgct ccgcccgcgc cccgtgcgcc tgagcaccga gctcgcccct      300

cctccgcgct aactccgccg cccgctcccc aggccgcccg cgctccccgc gcgcctcctc      360

gggctccacg cgtcttgccc cgcagaggca gcctcctcca ggagcggggc cctgcacacc      420

atggcccccg ggtgggcagg ggtcggcgcc gccgtgcgcg cccgcctggc gctggccttg      480

gcgctggcga gcgtcctgag tgggcctcca gccgtcgcct gccccaccaa gtgtacctgc      540

tccgctgcca gcgtggactg ccacgggctg ggcctccgcg cggttcctcg gggcatcccc      600

cgcaacgctg agcgccttga cctggacaga aataatatca ccaggatcac caagatggac      660

ttcgctgggc tcaagaacct ccgagtcttg catctggaag acaaccaggt cagcgtcatc      720

gagagaggcg ccttccagga cctgaagcag ctagagcgac tgcgcctgaa caagaataag      780

ctgcaagtcc ttccagaatt gcttttccag agcacgccga agctcaccag actagatttg      840

agtgaaaacc agatccaggg gatcccgagg aaggcgttcc gcggcatcac cgatgtgaag      900

aacctgcaac tggacaacaa ccacatcagc tgcattgaag atggagcctt ccgagcgctg      960

cgcgatttgg agatccttac cctcaacaac aacaacatca gtcgcatcct ggtcaccagc     1020

ttcaaccaca tgccgaagat ccgaactctg cgcctccact ccaaccacct gtactgcgac     1080

tgccacctgg cctggctctc ggattggctg cgacagcgac ggacagttgg ccagttcaca     1140

ctctgcatgg ctcctgtgca tttgaggggc ttcaacgtgg cggatgtgca gaagaaggag     1200

tacgtgtgcc cagcccccca ctcggagccc ccatcctgca atgccaactc catctcctgc     1260

ccttcgccct gcacgtgcag caataacatc gtggactgtc gaggaaaggg cttgatggag     1320

attcctgcca acttgccgga gggcatcgtc gaaatacgcc tagaacagaa ctccatcaaa     1380

gccatccctg caggagcctt cacccagtac aagaaactga agcgaataga catcagcaag     1440

aatcagatat cggatattgc tccagatgcc ttccagggcc tgaaatcact cacatcgctg     1500

gtcctgtatg ggaacaagat caccgagatt gccaagggac tgtttgatgg gctggtgtcc     1560

ctacagctgc tcctcctcaa tgccaacaag atcaactgcc tgcgggtgaa cacgtttcag     1620

gacctgcaga acctcaactt gctctccctg tatgacaaca agctgcagac catcagcaag     1680

gggctcttcg cccctctgca gtccatccag acactccact tagcccaaaa cccatttgtg     1740

tgcgactgcc acttgaagtg gctggccgac tacctccagg acaaccccat cgagacaagc     1800

ggggcccgct gcagcagccc gcgccgactc gccaacaagc gcatcagcca gatcaagagc     1860

aagaagttcc gctgctcagg ctccgaggat taccgcagca ggttcagcag cgagtgcttc     1920

atggacctcg tgtgccccga gaagtgtcgc tgtgagggca cgattgtgga ctgctccaac     1980

cagaagctgg tccgcatccc aagccacctc cctgaatatg tcaccgacct gcgactgaat     2040

gacaatgagg tatctgttct ggaggccact ggcatcttca agaagttgcc caacctgcgg     2100

aaaataaatc tgagtaacaa taagatcaag gaggtgcgag agggagcttt cgatggagca     2160

gccagcgtgc aggagctgat gctgacaggg aaccagctgg agaccgtgca cgggcgcgtg     2220

ttccgtggcc tcagtggcct caaaaccttg atgctgagga gtaacttgat cggctgtgtg     2280

agtaatgaca cctttgccgg cctgagttcg gtgagactgc tgtccctcta tgacaatcgg     2340

atcaccacca tcacccctgg ggccttcacc acgcttgtct ccctgtccac cataaacctc     2400

ctgtccaacc ccttcaactg caactgccac ctggcctggc tcggcaagtg gttgaggaag     2460

aggcggatcg tcagtgggaa ccctaggtgc cagaagccat ttttcctcaa ggagattccc     2520

atccaggatg tggccatcca ggacttcacc tgtgatggca acgaggagag tagctgccag     2580

ctgagcccgc gctgcccgga gcagtgcacc tgtatggaga cagtggtgcg atgcagcaac     2640

aaggggctcc gcgccctccc cagaggcatg cccaaggatg tgaccgagct gtacctggaa     2700

ggaaaccacc taacagccgt gcccagagag ctgtccgccc tccgacacct gacgcttatt     2760

gacctgagca acaacagcat cagcatgctg accaattaca ccttcagtaa catgtctcac     2820

ctctccactc tgatcctgag ctacaaccgg ctgaggtgca tccccgtcca cgccttcaac     2880

gggctgcggt ccctgcgagt gctaaccctc catggcaatg acatttccag cgttcctgaa     2940

ggctccttca acgacctcac atctctttcc catctggcgc tgggaaccaa cccactccac     3000

tgtgactgca gtcttcggtg gctgtcggag tgggtgaagg cggggtacaa ggagcctggc     3060

atcgcccgct gcagtagccc tgagcccatg gctgacaggc tcctgctcac caccccaacc     3120

caccgcttcc agtgcaaagg gccagtggac atcaacattg tggccaaatg caatgcctgc     3180

ctctccagcc cgtgcaagaa taacgggaca tgcacccagg accctgtgga gctgtaccgc     3240

tgtgcctgcc cctacagcta caagggcaag gactgcactg tgcccatcaa cacctgcatc     3300

cagaacccct gtcagcatgg aggcacctgc cacctgagtg acagccacaa ggatgggttc     3360

agctgctcct gccctctggg ctttgagggg cagcggtgtg agatcaaccc agatgactgt     3420

gaggacaacg actgcgaaaa caatgccacc tgcgtggacg ggatcaacaa ctacgtgtgt     3480

atctgtccgc ctaactacac aggtgagcta tgcgacgagg tgattgacca ctgtgtgcct     3540

gagctgaacc tctgtcagca tgaggccaag tgcatccccc tggacaaagg attcagctgc     3600

gagtgtgtcc ctggctacag cgggaagctc tgtgagacag acaatgatga ctgtgtggcc     3660

cacaagtgcc gccacggggc ccagtgcgtg gacacaatca atggctacac atgcacctgc     3720

ccccagggct tcagtggacc cttctgtgaa caccccccac ccatggtcct actgcagacc     3780

agcccatgcg accagtacga gtgccagaac ggggcccagt gcatcgtggt gcagcaggag     3840

cccacctgcc gctgcccacc aggcttcgcc ggccccagat gcgagaagct catcactgtc     3900

aacttcgtgg gcaaagactc ctacgtggaa ctggcctccg ccaaggtccg accccaggcc     3960

aacatctccc tgcaggtggc cactgacaag gacaacggca tccttctcta caaaggagac     4020

aatgaccccc tggcactgga gctgtaccag ggccacgtgc ggctggtcta tgacagcctg     4080

agttcccctc caaccacagt gtacagtgtg gagacagtga atgatgggca gtttcacagt     4140

gtggagctgg tgacgctaaa ccagaccctg aacctagtag tggacaaagg aactccaaag     4200

agcctgggga agctccagaa gcagccagca gtgggcatca acagccccct ctaccttgga     4260

ggcatcccca cctccaccgg cctctctgcc ttgcgccagg gcacggaccg gcctctaggc     4320

ggcttccacg gatgcatcca tgaggtgcgc atcaacaacg agctgcagga cttcaaggcc     4380

ctcccaccac agtccctggg ggtgtcacca ggctgcaagt cctgcaccgt gtgcaagcac     4440

ggcctgtgcc gctccgtgga gaaggacagc gtggtgtgcg agtgccgccc aggctggacc     4500

ggcccactct gcgatcagga ggcccgggac ccctgcctcg gccacagatg ccaccatgga     4560

aaatgtgtgg caactgggac ctcatacatg tgcaagtgtg ccgagggcta tggaggggac     4620

ttgtgtgaca acaagaatga ctctgccaat gcctgctcag ccttcaagtg tcaccatggg     4680

cagtgccaca tctcagacca aggggagccc tactgcctgt gccagcccgg ctttagcggc     4740

gagcactgcc aacaagagaa tccgtgcctg ggacaagtag tccgagaggt gatccgccgc     4800

cagaaaggtt atgcatcatg tgccacagcc tccaaggtgc ccatcatgga atgtcgtggg     4860

ggctgtgggc cccagtgctg ccagcccacc cgcagcaagc ggcggaaata cgtcttccag     4920

tgcacggacg gctcctcgtt tgtagaagag gtggagagac acttagagtg cggctgcctc     4980

gcgtgttcct aagcccctgc ccgcctgcct gccacctctc ggactccagc ttgatggagt     5040

tgggacagcc atgtgggacc ccctggtgat tcagcatgaa ggaaatgaag ctggagagga     5100

aggtaaagaa gaagagaata ttaagtatat tgtaaaataa acaaaaaata gaacttattt     5160

ttattatgga aagtgactat tttcatcttt tattatataa atatattaca ccatctgcgt     5220

atatgtacca tatagtgagt tatttttacc aagttttgtg ttgtgtattt gttgtgtttt     5280

taaaaatagc tgtttaaaaa tttaagaaaa aaatagacta ataaaaatgc tttaaaacaa     5340

aaggataaga ataaagaatg atagcctgtc tgaggaagga ggaagatgtt ttcatgttta     5400

tgaaacggta ttatgtcggc agtagaccaa gagctgctca ttgagatcag aaaaaggaat     5460

aagaggaaga gagagaagga aaagaccttt gtttcttgtt ttttaactcc cttttatttt     5520

tcctccccta aaattaccca gcttttcgga gtcctggatg tcagtgccca aaatgcccag     5580

ttcttccagg aaaagctgct gagccctggc cttctcagtc tcactgccac tcaaaaatat     5640

tgctgtccct gtctgtccca gacccccctt cagggtatct gaacccactg ggggacccct     5700

cttctccttc ctgggtggcc ctggcttccg tatctgaacc cactggggga cccctcttct     5760

ccttcctggc tggccctggc ttccaatcga ggactgacta ttgaagtctg ctacaggtgt     5820

catttggaac tgtcttacca aattttaaaa cagctgctat ttttcctgct cctccccagg     5880

agaggggtct tcctagagga ggcgagggaa gagaatatca tggtgtctcc tcaggaccca     5940

tgcactggcc ctctctcctc cttccaggta atttttcatt ggaatgtatc ccagtagaga     6000

aggtagtcag cccttcttgg aagcggaagg ctgggagcca agtcaagtct gcccacagcg     6060

ctagatgtcc aactctggaa ggttcttgga ggctcttgtt gtaagacagg cctctgccac     6120

ctgatcctcc aggtcaccag catgacgata gagactcctt gcccatctgt gacactttcc     6180

aatgcatatc caaactttac cttattttat ctatgcaacc cctgcctccc tgggaaggat     6240

aagggagtag agctgggttc actaagaagg aagtttaggc cctcacaggc tctggaactt     6300

gccttaagcc acacaccaga taagtggagg agccagacca gaagtccaga cccaaagctt     6360

gagattcttc ctctagaatg ggtgagcaca ggtgattcag gcggcttaaa tccatcagag     6420

cagccctgcc ggaaaaggaa ataatatgat gttttttcct gctcttgttc tgccttgctc     6480

actccttctc cctccgcagt atctggaaag attctggaga ccagggctta tgcatctagg     6540

gaaagtgacc aagggcagcc tatccagcct ctgcctccat tcctgaaggg gacttccctg     6600

cccctgtttc tttccatgtc tctccctccc tcactcccat ttgccccctt ccaccccatc     6660

aggttagcca catatcttcc agggctcagc tgttcacacc aactccctgg ctcttatcat     6720

ccatccctcc ttcccccagg agcttccact gtaggagttt cagggagaag agtttggaat     6780

tcattggacc tttcagccct caggttccct agaggagcct agttgatctg tgagtaccaa     6840

tggtgggcca aagacgcagg gaataatgaa gggagaaaga aaagaaagga agatggagga     6900

aaacgaggca actggaagaa ggaaggaagg aaagaaggaa gggatggagg ggatgaagag     6960

aagggagaga gggatatagc tgaggaattt atctaaaaat gtgcatgtaa atctccatta     7020

tgttccaggt actgtgcctt atgatggctt tgttttttgt tgtcattaga gacaaggtct     7080

tgctttgtca cccaggctgg agtagagtgg ttcgatcata gctcaccgca gcctcaacct     7140

cctaggctca agccatcttc ctgcctcagt ctcccaaaat gctgggatta caggtgtgag     7200

ccactatgct cagcctgttt caaacattat tataatagca gatttattta gtactttatt     7260

atacatcaga taccactcta attgtgaaat agatatatat tcatttaatt attgaaacaa     7320

ccatgtagtt aaaacactat taactcattt tacagttgag tagactgaga cacagagaag     7380

ttaaagaact tgcccaagag taaatgtcta ataaaccgta gagccaggat ctgggcccag     7440

gctgtctgac tccagaactt gctcactcaa ccactaaacc atcctgcttc tcatgggaaa     7500

gaaacacatc ctgcctttga ggatcctaca gcctgtgaca aaaacagtca taaaaatgga     7560

caattgcctt attacacaag gagctcttaa gtggcaatac aagcaatgga agtggctgtc     7620

cagaggaggg aacttctagt cctaggtctt taaggatgaa taggagtttg ccagagtgag     7680

aaagggaatt gaactttcct gggagtggcc ttttaaaaag caatgagata tggccaggcc     7740

tggcttgttt ggggaagagt caaaatctag ggtggcaaga gtatgggaag cacactgagg     7800

agcagagaga aatggggtag gtaggaaggt agggttttga ccacaaagag ctgtgcatgc     7860

taaactgggc cacaggtgcc agcagggttg tttgaggaag ggaagagcaa gacaagctct     7920

ggtttaggaa gagagctgtg gcagcataaa ggcctgaaag aggagacaga gctgtcaccc     7980

aaaatggact tgagagctcc ctgtggttta ctctgtggct agaaaacact gccggccaga     8040

tggatcacaa atgtctatgg tagcttagaa gctctgctct tgaagaggat cctgggatct     8100

gcccaacacc cttcccaacc tccatttccc catccccacc tccattgccc catcccccct     8160

ctccccctag gcaggtggat ctgagcctta tcccaccacc aatgcccctg ctagcctctc     8220

cccacccagc ccagagccta ctcagcctgc catctcaaga gccccaccga gggtcactgg     8280

cttcctggga ggagtcacca ggctgccagc tttccctctg cctccccaag gaacctgaga     8340

cctccctctg ctcatcaccc tgggcccaat cctgaatcca gcccccatca accaagacag     8400

caaaagggcc aggtctgtcc cttataattt tgagccttct ccctcaagtt tggaagccct     8460

gactttaaga aatgccaaat gcaaggacca ttaagaaaat tctccccgaa atgaggctcc     8520

tctaacaaat gatgattaaa acgctctctc cttgagcagt cacattctag aaacaggaca     8580

ttccatgagg caggaagagt tcagttaatt tgctcctgaa aaagtgtggt tcagtgtttg     8640

tgtggcaatg tacgtgggca gaagaggccg ctcaagctgt gtcccccctg agcaggattc     8700

aggaaaggga aaagaagttc tcttcaactc agccaagggg ccgtacgatg gccgatgaga     8760

ttatgtattt aaaagttctt tgtaaagtgt aaactaaaaa ccttaaatgt aagatgctgt     8820

tgttattatt actgttgttg ttgctgttat ggacatgcca aaaggccctt gttagaagac     8880

agttttgcct tttcaatctc atagcaagga actcaagtct gatgcttcaa aaagatgaga     8940

agaagggcaa gaagagggat aactcccaag ctcagaggga aaaaaaaggt gggggaaaag     9000

agccccaggg tgaccttcag gaaaggccag gaccaggatg atctaacctt tcccttcacc     9060

agaaacaaag ctattgccag actgaaccct aaagtcaagc agtcacccac tgcctttgct     9120

gggagcagaa gcccatagca acaagtgacc tgcccctcag actcaagatc ccagatacca     9180

gagctggagg agtcataggg cattactggt aggcaggaaa actgagggtc gaacaaatgg     9240

aagaatgcgg tgatcataga ccaaagacac acagataatt aaccccatgt gtccacccag     9300

gccaaagttc ttcctgctac cccacagtgg atgtccaggc agatggtccc cacatgatgg     9360

ggaagcagag ggcatagtgt ggttttgtgg gacttgttca tgttttgtag tgtgggctca     9420

acagtgccaa aggaaacact agggaaaagt tggtgaaaca tgccagctag caggaccagt     9480

aaaggcataa tcaggcattt ggcaaagctt gcttttctaa ttcaatgata ggttctaata     9540

ggaaattttt gaagattttt taaaacaatg ttatagtggc acttccccag tatggaataa     9600

ataacatgca ttcttttttc aatatactgt catattcaga tgtcattaaa ataaatggat     9660

gagtcacaga ggagctatca gatgctctca tgactaccat aactcagccc tgcaaaaaaa     9720

aaaaaaa                                                               9727


<210>  16
<211>  1523
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Pro Gly Trp Ala Gly Val Gly Ala Ala Val Arg Ala Arg Leu 
1               5                   10                  15      


Ala Leu Ala Leu Ala Leu Ala Ser Val Leu Ser Gly Pro Pro Ala Val 
            20                  25                  30          


Ala Cys Pro Thr Lys Cys Thr Cys Ser Ala Ala Ser Val Asp Cys His 
        35                  40                  45              


Gly Leu Gly Leu Arg Ala Val Pro Arg Gly Ile Pro Arg Asn Ala Glu 
    50                  55                  60                  


Arg Leu Asp Leu Asp Arg Asn Asn Ile Thr Arg Ile Thr Lys Met Asp 
65                  70                  75                  80  


Phe Ala Gly Leu Lys Asn Leu Arg Val Leu His Leu Glu Asp Asn Gln 
                85                  90                  95      


Val Ser Val Ile Glu Arg Gly Ala Phe Gln Asp Leu Lys Gln Leu Glu 
            100                 105                 110         


Arg Leu Arg Leu Asn Lys Asn Lys Leu Gln Val Leu Pro Glu Leu Leu 
        115                 120                 125             


Phe Gln Ser Thr Pro Lys Leu Thr Arg Leu Asp Leu Ser Glu Asn Gln 
    130                 135                 140                 


Ile Gln Gly Ile Pro Arg Lys Ala Phe Arg Gly Ile Thr Asp Val Lys 
145                 150                 155                 160 


Asn Leu Gln Leu Asp Asn Asn His Ile Ser Cys Ile Glu Asp Gly Ala 
                165                 170                 175     


Phe Arg Ala Leu Arg Asp Leu Glu Ile Leu Thr Leu Asn Asn Asn Asn 
            180                 185                 190         


Ile Ser Arg Ile Leu Val Thr Ser Phe Asn His Met Pro Lys Ile Arg 
        195                 200                 205             


Thr Leu Arg Leu His Ser Asn His Leu Tyr Cys Asp Cys His Leu Ala 
    210                 215                 220                 


Trp Leu Ser Asp Trp Leu Arg Gln Arg Arg Thr Val Gly Gln Phe Thr 
225                 230                 235                 240 


Leu Cys Met Ala Pro Val His Leu Arg Gly Phe Asn Val Ala Asp Val 
                245                 250                 255     


Gln Lys Lys Glu Tyr Val Cys Pro Ala Pro His Ser Glu Pro Pro Ser 
            260                 265                 270         


Cys Asn Ala Asn Ser Ile Ser Cys Pro Ser Pro Cys Thr Cys Ser Asn 
        275                 280                 285             


Asn Ile Val Asp Cys Arg Gly Lys Gly Leu Met Glu Ile Pro Ala Asn 
    290                 295                 300                 


Leu Pro Glu Gly Ile Val Glu Ile Arg Leu Glu Gln Asn Ser Ile Lys 
305                 310                 315                 320 


Ala Ile Pro Ala Gly Ala Phe Thr Gln Tyr Lys Lys Leu Lys Arg Ile 
                325                 330                 335     


Asp Ile Ser Lys Asn Gln Ile Ser Asp Ile Ala Pro Asp Ala Phe Gln 
            340                 345                 350         


Gly Leu Lys Ser Leu Thr Ser Leu Val Leu Tyr Gly Asn Lys Ile Thr 
        355                 360                 365             


Glu Ile Ala Lys Gly Leu Phe Asp Gly Leu Val Ser Leu Gln Leu Leu 
    370                 375                 380                 


Leu Leu Asn Ala Asn Lys Ile Asn Cys Leu Arg Val Asn Thr Phe Gln 
385                 390                 395                 400 


Asp Leu Gln Asn Leu Asn Leu Leu Ser Leu Tyr Asp Asn Lys Leu Gln 
                405                 410                 415     


Thr Ile Ser Lys Gly Leu Phe Ala Pro Leu Gln Ser Ile Gln Thr Leu 
            420                 425                 430         


His Leu Ala Gln Asn Pro Phe Val Cys Asp Cys His Leu Lys Trp Leu 
        435                 440                 445             


Ala Asp Tyr Leu Gln Asp Asn Pro Ile Glu Thr Ser Gly Ala Arg Cys 
    450                 455                 460                 


Ser Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Ser Gln Ile Lys Ser 
465                 470                 475                 480 


Lys Lys Phe Arg Cys Ser Gly Ser Glu Asp Tyr Arg Ser Arg Phe Ser 
                485                 490                 495     


Ser Glu Cys Phe Met Asp Leu Val Cys Pro Glu Lys Cys Arg Cys Glu 
            500                 505                 510         


Gly Thr Ile Val Asp Cys Ser Asn Gln Lys Leu Val Arg Ile Pro Ser 
        515                 520                 525             


His Leu Pro Glu Tyr Val Thr Asp Leu Arg Leu Asn Asp Asn Glu Val 
    530                 535                 540                 


Ser Val Leu Glu Ala Thr Gly Ile Phe Lys Lys Leu Pro Asn Leu Arg 
545                 550                 555                 560 


Lys Ile Asn Leu Ser Asn Asn Lys Ile Lys Glu Val Arg Glu Gly Ala 
                565                 570                 575     


Phe Asp Gly Ala Ala Ser Val Gln Glu Leu Met Leu Thr Gly Asn Gln 
            580                 585                 590         


Leu Glu Thr Val His Gly Arg Val Phe Arg Gly Leu Ser Gly Leu Lys 
        595                 600                 605             


Thr Leu Met Leu Arg Ser Asn Leu Ile Gly Cys Val Ser Asn Asp Thr 
    610                 615                 620                 


Phe Ala Gly Leu Ser Ser Val Arg Leu Leu Ser Leu Tyr Asp Asn Arg 
625                 630                 635                 640 


Ile Thr Thr Ile Thr Pro Gly Ala Phe Thr Thr Leu Val Ser Leu Ser 
                645                 650                 655     


Thr Ile Asn Leu Leu Ser Asn Pro Phe Asn Cys Asn Cys His Leu Ala 
            660                 665                 670         


Trp Leu Gly Lys Trp Leu Arg Lys Arg Arg Ile Val Ser Gly Asn Pro 
        675                 680                 685             


Arg Cys Gln Lys Pro Phe Phe Leu Lys Glu Ile Pro Ile Gln Asp Val 
    690                 695                 700                 


Ala Ile Gln Asp Phe Thr Cys Asp Gly Asn Glu Glu Ser Ser Cys Gln 
705                 710                 715                 720 


Leu Ser Pro Arg Cys Pro Glu Gln Cys Thr Cys Met Glu Thr Val Val 
                725                 730                 735     


Arg Cys Ser Asn Lys Gly Leu Arg Ala Leu Pro Arg Gly Met Pro Lys 
            740                 745                 750         


Asp Val Thr Glu Leu Tyr Leu Glu Gly Asn His Leu Thr Ala Val Pro 
        755                 760                 765             


Arg Glu Leu Ser Ala Leu Arg His Leu Thr Leu Ile Asp Leu Ser Asn 
    770                 775                 780                 


Asn Ser Ile Ser Met Leu Thr Asn Tyr Thr Phe Ser Asn Met Ser His 
785                 790                 795                 800 


Leu Ser Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg Cys Ile Pro Val 
                805                 810                 815     


His Ala Phe Asn Gly Leu Arg Ser Leu Arg Val Leu Thr Leu His Gly 
            820                 825                 830         


Asn Asp Ile Ser Ser Val Pro Glu Gly Ser Phe Asn Asp Leu Thr Ser 
        835                 840                 845             


Leu Ser His Leu Ala Leu Gly Thr Asn Pro Leu His Cys Asp Cys Ser 
    850                 855                 860                 


Leu Arg Trp Leu Ser Glu Trp Val Lys Ala Gly Tyr Lys Glu Pro Gly 
865                 870                 875                 880 


Ile Ala Arg Cys Ser Ser Pro Glu Pro Met Ala Asp Arg Leu Leu Leu 
                885                 890                 895     


Thr Thr Pro Thr His Arg Phe Gln Cys Lys Gly Pro Val Asp Ile Asn 
            900                 905                 910         


Ile Val Ala Lys Cys Asn Ala Cys Leu Ser Ser Pro Cys Lys Asn Asn 
        915                 920                 925             


Gly Thr Cys Thr Gln Asp Pro Val Glu Leu Tyr Arg Cys Ala Cys Pro 
    930                 935                 940                 


Tyr Ser Tyr Lys Gly Lys Asp Cys Thr Val Pro Ile Asn Thr Cys Ile 
945                 950                 955                 960 


Gln Asn Pro Cys Gln His Gly Gly Thr Cys His Leu Ser Asp Ser His 
                965                 970                 975     


Lys Asp Gly Phe Ser Cys Ser Cys Pro Leu Gly Phe Glu Gly Gln Arg 
            980                 985                 990         


Cys Glu Ile Asn Pro Asp Asp Cys  Glu Asp Asn Asp Cys  Glu Asn Asn 
        995                 1000                 1005             


Ala Thr  Cys Val Asp Gly Ile  Asn Asn Tyr Val Cys  Ile Cys Pro 
    1010                 1015                 1020             


Pro Asn  Tyr Thr Gly Glu Leu  Cys Asp Glu Val Ile  Asp His Cys 
    1025                 1030                 1035             


Val Pro  Glu Leu Asn Leu Cys  Gln His Glu Ala Lys  Cys Ile Pro 
    1040                 1045                 1050             


Leu Asp  Lys Gly Phe Ser Cys  Glu Cys Val Pro Gly  Tyr Ser Gly 
    1055                 1060                 1065             


Lys Leu  Cys Glu Thr Asp Asn  Asp Asp Cys Val Ala  His Lys Cys 
    1070                 1075                 1080             


Arg His  Gly Ala Gln Cys Val  Asp Thr Ile Asn Gly  Tyr Thr Cys 
    1085                 1090                 1095             


Thr Cys  Pro Gln Gly Phe Ser  Gly Pro Phe Cys Glu  His Pro Pro 
    1100                 1105                 1110             


Pro Met  Val Leu Leu Gln Thr  Ser Pro Cys Asp Gln  Tyr Glu Cys 
    1115                 1120                 1125             


Gln Asn  Gly Ala Gln Cys Ile  Val Val Gln Gln Glu  Pro Thr Cys 
    1130                 1135                 1140             


Arg Cys  Pro Pro Gly Phe Ala  Gly Pro Arg Cys Glu  Lys Leu Ile 
    1145                 1150                 1155             


Thr Val  Asn Phe Val Gly Lys  Asp Ser Tyr Val Glu  Leu Ala Ser 
    1160                 1165                 1170             


Ala Lys  Val Arg Pro Gln Ala  Asn Ile Ser Leu Gln  Val Ala Thr 
    1175                 1180                 1185             


Asp Lys  Asp Asn Gly Ile Leu  Leu Tyr Lys Gly Asp  Asn Asp Pro 
    1190                 1195                 1200             


Leu Ala  Leu Glu Leu Tyr Gln  Gly His Val Arg Leu  Val Tyr Asp 
    1205                 1210                 1215             


Ser Leu  Ser Ser Pro Pro Thr  Thr Val Tyr Ser Val  Glu Thr Val 
    1220                 1225                 1230             


Asn Asp  Gly Gln Phe His Ser  Val Glu Leu Val Thr  Leu Asn Gln 
    1235                 1240                 1245             


Thr Leu  Asn Leu Val Val Asp  Lys Gly Thr Pro Lys  Ser Leu Gly 
    1250                 1255                 1260             


Lys Leu  Gln Lys Gln Pro Ala  Val Gly Ile Asn Ser  Pro Leu Tyr 
    1265                 1270                 1275             


Leu Gly  Gly Ile Pro Thr Ser  Thr Gly Leu Ser Ala  Leu Arg Gln 
    1280                 1285                 1290             


Gly Thr  Asp Arg Pro Leu Gly  Gly Phe His Gly Cys  Ile His Glu 
    1295                 1300                 1305             


Val Arg  Ile Asn Asn Glu Leu  Gln Asp Phe Lys Ala  Leu Pro Pro 
    1310                 1315                 1320             


Gln Ser  Leu Gly Val Ser Pro  Gly Cys Lys Ser Cys  Thr Val Cys 
    1325                 1330                 1335             


Lys His  Gly Leu Cys Arg Ser  Val Glu Lys Asp Ser  Val Val Cys 
    1340                 1345                 1350             


Glu Cys  Arg Pro Gly Trp Thr  Gly Pro Leu Cys Asp  Gln Glu Ala 
    1355                 1360                 1365             


Arg Asp  Pro Cys Leu Gly His  Arg Cys His His Gly  Lys Cys Val 
    1370                 1375                 1380             


Ala Thr  Gly Thr Ser Tyr Met  Cys Lys Cys Ala Glu  Gly Tyr Gly 
    1385                 1390                 1395             


Gly Asp  Leu Cys Asp Asn Lys  Asn Asp Ser Ala Asn  Ala Cys Ser 
    1400                 1405                 1410             


Ala Phe  Lys Cys His His Gly  Gln Cys His Ile Ser  Asp Gln Gly 
    1415                 1420                 1425             


Glu Pro  Tyr Cys Leu Cys Gln  Pro Gly Phe Ser Gly  Glu His Cys 
    1430                 1435                 1440             


Gln Gln  Glu Asn Pro Cys Leu  Gly Gln Val Val Arg  Glu Val Ile 
    1445                 1450                 1455             


Arg Arg  Gln Lys Gly Tyr Ala  Ser Cys Ala Thr Ala  Ser Lys Val 
    1460                 1465                 1470             


Pro Ile  Met Glu Cys Arg Gly  Gly Cys Gly Pro Gln  Cys Cys Gln 
    1475                 1480                 1485             


Pro Thr  Arg Ser Lys Arg Arg  Lys Tyr Val Phe Gln  Cys Thr Asp 
    1490                 1495                 1500             


Gly Ser  Ser Phe Val Glu Glu  Val Glu Arg His Leu  Glu Cys Gly 
    1505                 1510                 1515             


Cys Leu  Ala Cys Ser 
    1520             


<210>  17
<211>  1523
<212>  PRT
<213>  Mus musculus

<400>  17

Met Ala Leu Gly Arg Thr Gly Ala Gly Ala Ala Val Arg Ala Arg Leu 
1               5                   10                  15      


Ala Leu Gly Leu Ala Leu Ala Ser Ile Leu Ser Gly Pro Pro Ala Ala 
            20                  25                  30          


Ala Cys Pro Thr Lys Cys Thr Cys Ser Ala Ala Ser Val Asp Cys His 
        35                  40                  45              


Gly Leu Gly Leu Arg Ala Val Pro Arg Gly Ile Pro Arg Asn Ala Glu 
    50                  55                  60                  


Arg Leu Asp Leu Asp Arg Asn Asn Ile Thr Arg Ile Thr Lys Met Asp 
65                  70                  75                  80  


Phe Ala Gly Leu Lys Asn Leu Arg Val Leu His Leu Glu Asp Asn Gln 
                85                  90                  95      


Val Ser Ile Ile Glu Arg Gly Ala Phe Gln Asp Leu Lys Gln Leu Glu 
            100                 105                 110         


Arg Leu Arg Leu Asn Lys Asn Lys Leu Gln Val Leu Pro Glu Leu Leu 
        115                 120                 125             


Phe Gln Ser Thr Pro Lys Leu Thr Arg Leu Asp Leu Ser Glu Asn Gln 
    130                 135                 140                 


Ile Gln Gly Ile Pro Arg Lys Ala Phe Arg Gly Val Thr Gly Val Lys 
145                 150                 155                 160 


Asn Leu Gln Leu Asp Asn Asn His Ile Ser Cys Ile Glu Asp Gly Ala 
                165                 170                 175     


Phe Arg Ala Leu Arg Asp Leu Glu Ile Leu Thr Leu Asn Asn Asn Asn 
            180                 185                 190         


Ile Ser Arg Ile Leu Val Thr Ser Phe Asn His Met Pro Lys Ile Arg 
        195                 200                 205             


Thr Leu Arg Leu His Ser Asn His Leu Tyr Cys Asp Cys His Leu Ala 
    210                 215                 220                 


Trp Leu Ser Asp Trp Leu Arg Gln Arg Arg Thr Ile Gly Gln Phe Thr 
225                 230                 235                 240 


Leu Cys Met Ala Pro Val His Leu Arg Gly Phe Ser Val Ala Asp Val 
                245                 250                 255     


Gln Lys Lys Glu Tyr Val Cys Pro Gly Pro His Ser Glu Ala Pro Ala 
            260                 265                 270         


Cys Asn Ala Asn Ser Leu Ser Cys Pro Ser Ala Cys Ser Cys Ser Asn 
        275                 280                 285             


Asn Ile Val Asp Cys Arg Gly Lys Gly Leu Thr Glu Ile Pro Ala Asn 
    290                 295                 300                 


Leu Pro Glu Gly Ile Val Glu Ile Arg Leu Glu Gln Asn Ser Ile Lys 
305                 310                 315                 320 


Ser Ile Pro Ala Gly Ala Phe Thr Gln Tyr Lys Lys Leu Lys Arg Ile 
                325                 330                 335     


Asp Ile Ser Lys Asn Gln Ile Ser Asp Ile Ala Pro Asp Ala Phe Gln 
            340                 345                 350         


Gly Leu Lys Ser Leu Thr Ser Leu Val Leu Tyr Gly Asn Lys Ile Thr 
        355                 360                 365             


Glu Ile Pro Lys Gly Leu Phe Asp Gly Leu Val Ser Leu Gln Leu Leu 
    370                 375                 380                 


Leu Leu Asn Ala Asn Lys Ile Asn Cys Leu Arg Val Asn Thr Phe Gln 
385                 390                 395                 400 


Asp Leu Gln Asn Leu Asn Leu Leu Ser Leu Tyr Asp Asn Lys Leu Gln 
                405                 410                 415     


Thr Ile Ser Lys Gly Leu Phe Val Pro Leu Gln Ser Ile Gln Thr Leu 
            420                 425                 430         


His Leu Ala Gln Asn Pro Phe Val Cys Asp Cys His Leu Lys Trp Leu 
        435                 440                 445             


Ala Asp Tyr Leu Gln Asp Asn Pro Ile Glu Thr Ser Gly Ala Arg Cys 
    450                 455                 460                 


Ser Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Ser Gln Ile Lys Ser 
465                 470                 475                 480 


Lys Lys Phe Arg Cys Ser Gly Ser Glu Asp Tyr Arg Asn Arg Phe Ser 
                485                 490                 495     


Ser Glu Cys Phe Met Asp Leu Val Cys Pro Glu Lys Cys Arg Cys Glu 
            500                 505                 510         


Gly Thr Ile Val Asp Cys Ser Asn Gln Lys Leu Ala Arg Ile Pro Ser 
        515                 520                 525             


His Leu Pro Glu Tyr Thr Thr Asp Leu Arg Leu Asn Asp Asn Asp Ile 
    530                 535                 540                 


Ser Val Leu Glu Ala Thr Gly Ile Phe Lys Lys Leu Pro Asn Leu Arg 
545                 550                 555                 560 


Lys Ile Asn Leu Ser Asn Asn Arg Ile Lys Glu Val Arg Glu Gly Ala 
                565                 570                 575     


Phe Asp Gly Ala Ala Gly Val Gln Glu Leu Met Leu Thr Gly Asn Gln 
            580                 585                 590         


Leu Glu Thr Met His Gly Arg Met Phe Arg Gly Leu Ser Ser Leu Lys 
        595                 600                 605             


Thr Leu Met Leu Arg Ser Asn Leu Ile Ser Cys Val Ser Asn Asp Thr 
    610                 615                 620                 


Phe Ala Gly Leu Ser Ser Val Arg Leu Leu Ser Leu Tyr Asp Asn Arg 
625                 630                 635                 640 


Ile Thr Thr Ile Thr Pro Gly Ala Phe Thr Thr Leu Val Ser Leu Ser 
                645                 650                 655     


Thr Ile Asn Leu Leu Ser Asn Pro Phe Asn Cys Asn Cys His Met Ala 
            660                 665                 670         


Trp Leu Gly Arg Trp Leu Arg Lys Arg Arg Ile Val Ser Gly Asn Pro 
        675                 680                 685             


Arg Cys Gln Lys Pro Phe Phe Leu Lys Glu Ile Pro Ile Gln Asp Val 
    690                 695                 700                 


Ala Ile Gln Asp Phe Thr Cys Asp Gly Asn Glu Glu Ser Ser Cys Gln 
705                 710                 715                 720 


Leu Ser Pro Arg Cys Pro Glu Gln Cys Thr Cys Val Glu Thr Val Val 
                725                 730                 735     


Arg Cys Ser Asn Arg Gly Leu His Ala Leu Pro Lys Gly Met Pro Lys 
            740                 745                 750         


Asp Val Thr Glu Leu Tyr Leu Glu Gly Asn His Leu Thr Ala Val Pro 
        755                 760                 765             


Lys Glu Leu Ser Ala Phe Arg Gln Leu Thr Leu Ile Asp Leu Ser Asn 
    770                 775                 780                 


Asn Ser Ile Ser Met Leu Thr Asn His Thr Phe Ser Asn Met Ser His 
785                 790                 795                 800 


Leu Ser Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg Cys Ile Pro Val 
                805                 810                 815     


His Ala Phe Asn Gly Leu Arg Ser Leu Arg Val Leu Thr Leu His Gly 
            820                 825                 830         


Asn Asp Ile Ser Ser Val Pro Glu Gly Ser Phe Asn Asp Leu Thr Ser 
        835                 840                 845             


Leu Ser His Leu Ala Leu Gly Thr Asn Pro Leu His Cys Asp Cys Ser 
    850                 855                 860                 


Leu Arg Trp Leu Ser Glu Trp Val Lys Ala Gly Tyr Lys Glu Pro Gly 
865                 870                 875                 880 


Ile Ala Arg Cys Ser Ser Pro Glu Ser Met Ala Asp Arg Leu Leu Leu 
                885                 890                 895     


Thr Thr Pro Thr His Arg Phe Gln Cys Lys Gly Pro Val Asp Ile Asn 
            900                 905                 910         


Ile Val Ala Lys Cys Asn Ala Cys Leu Ser Ser Pro Cys Lys Asn Asn 
        915                 920                 925             


Gly Thr Cys Ser Gln Asp Pro Val Glu Gln Tyr Arg Cys Thr Cys Pro 
    930                 935                 940                 


Tyr Ser Tyr Lys Gly Lys Asp Cys Thr Val Pro Ile Asn Thr Cys Val 
945                 950                 955                 960 


Gln Asn Pro Cys Glu His Gly Gly Thr Cys His Leu Ser Glu Asn Leu 
                965                 970                 975     


Arg Asp Gly Phe Ser Cys Ser Cys Pro Leu Gly Phe Glu Gly Gln Arg 
            980                 985                 990         


Cys Glu Ile Asn Pro Asp Asp Cys  Glu Asp Asn Asp Cys  Glu Asn Ser 
        995                 1000                 1005             


Ala Thr  Cys Val Asp Gly Ile  Asn Asn Tyr Ala Cys  Leu Cys Pro 
    1010                 1015                 1020             


Pro Asn  Tyr Thr Gly Glu Leu  Cys Asp Glu Val Ile  Asp Tyr Cys 
    1025                 1030                 1035             


Val Pro  Glu Met Asn Leu Cys  Gln His Glu Ala Lys  Cys Ile Ser 
    1040                 1045                 1050             


Leu Asp  Lys Gly Phe Arg Cys  Glu Cys Val Pro Gly  Tyr Ser Gly 
    1055                 1060                 1065             


Lys Leu  Cys Glu Thr Asn Asn  Asp Asp Cys Val Ala  His Lys Cys 
    1070                 1075                 1080             


Arg His  Gly Ala Gln Cys Val  Asp Glu Val Asn Gly  Tyr Thr Cys 
    1085                 1090                 1095             


Ile Cys  Pro Gln Gly Phe Ser  Gly Leu Phe Cys Glu  His Pro Pro 
    1100                 1105                 1110             


Pro Met  Val Leu Leu Gln Thr  Ser Pro Cys Asp Gln  Tyr Glu Cys 
    1115                 1120                 1125             


Gln Asn  Gly Ala Gln Cys Ile  Val Val Gln Gln Glu  Pro Thr Cys 
    1130                 1135                 1140             


Arg Cys  Pro Pro Gly Phe Ala  Gly Pro Arg Cys Glu  Lys Leu Ile 
    1145                 1150                 1155             


Thr Val  Asn Phe Val Gly Lys  Asp Ser Tyr Val Glu  Leu Ala Ser 
    1160                 1165                 1170             


Ala Lys  Val Arg Pro Gln Ala  Asn Ile Ser Leu Gln  Val Ala Thr 
    1175                 1180                 1185             


Asp Lys  Asp Asn Gly Ile Leu  Leu Tyr Lys Gly Asp  Asn Asp Pro 
    1190                 1195                 1200             


Leu Ala  Leu Glu Leu Tyr Gln  Gly His Val Arg Leu  Val Tyr Asp 
    1205                 1210                 1215             


Ser Leu  Ser Ser Pro Pro Thr  Thr Val Tyr Ser Val  Glu Thr Val 
    1220                 1225                 1230             


Asn Asp  Gly Gln Phe His Ser  Val Glu Leu Val Met  Leu Asn Gln 
    1235                 1240                 1245             


Thr Leu  Asn Leu Val Val Asp  Lys Gly Ala Pro Lys  Ser Leu Gly 
    1250                 1255                 1260             


Lys Leu  Gln Lys Gln Pro Ala  Val Gly Ser Asn Ser  Pro Leu Tyr 
    1265                 1270                 1275             


Leu Gly  Gly Ile Pro Thr Ser  Thr Gly Leu Ser Ala  Leu Arg Gln 
    1280                 1285                 1290             


Gly Ala  Asp Arg Pro Leu Gly  Gly Phe His Gly Cys  Ile His Glu 
    1295                 1300                 1305             


Val Arg  Ile Asn Asn Glu Leu  Gln Asp Phe Lys Ala  Leu Pro Pro 
    1310                 1315                 1320             


Gln Ser  Leu Gly Val Ser Pro  Gly Cys Lys Ser Cys  Thr Val Cys 
    1325                 1330                 1335             


Arg His  Gly Leu Cys Arg Ser  Val Glu Lys Asp Ser  Val Val Cys 
    1340                 1345                 1350             


Glu Cys  His Pro Gly Trp Thr  Gly Pro Leu Cys Asp  Gln Glu Ala 
    1355                 1360                 1365             


Arg Asp  Pro Cys Leu Gly His  Ser Cys Arg His Gly  Thr Cys Met 
    1370                 1375                 1380             


Ala Thr  Gly Asp Ser Tyr Val  Cys Lys Cys Ala Glu  Gly Tyr Gly 
    1385                 1390                 1395             


Gly Ala  Leu Cys Asp Gln Lys  Asn Asp Ser Ala Ser  Ala Cys Ser 
    1400                 1405                 1410             


Ala Phe  Lys Cys His His Gly  Gln Cys His Ile Ser  Asp Arg Gly 
    1415                 1420                 1425             


Glu Pro  Tyr Cys Leu Cys Gln  Pro Gly Phe Ser Gly  His His Cys 
    1430                 1435                 1440             


Glu Gln  Glu Asn Pro Cys Met  Gly Glu Ile Val Arg  Glu Ala Ile 
    1445                 1450                 1455             


Arg Arg  Gln Lys Asp Tyr Ala  Ser Cys Ala Thr Ala  Ser Lys Val 
    1460                 1465                 1470             


Pro Ile  Met Glu Cys Arg Gly  Gly Cys Gly Ser Gln  Cys Cys Gln 
    1475                 1480                 1485             


Pro Ile  Arg Ser Lys Arg Arg  Lys Tyr Val Phe Gln  Cys Thr Asp 
    1490                 1495                 1500             


Gly Ser  Ser Phe Val Glu Glu  Val Glu Arg His Leu  Glu Cys Gly 
    1505                 1510                 1515             


Cys Arg  Ala Cys Ser 
    1520             


<210>  18
<211>  3078
<212>  DNA
<213>  Homo sapiens

<400>  18
gtagctgaga tgcagagagc catcctgccc agacctagac aactcggaag tgggtttttc       60

agcctcctgc accggtgtcg cgtctgagtg cgactgatga gccagggggc gtcggtggaa      120

gcttggggtc ggcagtctgg ttggaaagga gaggctagtg gtaacaggcc gagctggatg      180

gatgggtatg gggagagggg caggacgttc agccctggga ttctggccga ccctcgcctt      240

ccttctctgc agcttccccg cagccacctc cccgtgcaag atcctcaagt gcaactctga      300

gttctggagc gccacgtcgg gcagccacgc cccagcctca gacgacaccc ccgagttctg      360

tgcagccttg cgcagctacg ccctgtgcac gcggcggacg gcccgcacct gccggggtga      420

cctggcctac cactcggccg tccatggcat agaggacctc atgagccagc acaactgctc      480

caaggatggc cccacctcgc agccacgcct gcgcacgctc ccaccggccg gagacagcca      540

ggagcgctcg gacagccccg agatctgcca ttacgagaag agctttcaca agcactcggc      600

cacccccaac tacacgcact gtggcctctt cggggaccca cacctcagga ctttcaccga      660

ccgcttccag acctgcaagg tgcagggcgc ctggccgctc atcgacaata attacctgaa      720

cgtgcaggtc accaacacgc ctgtgctgcc cggctcagcg gccactgcca ccagcaagct      780

caccatcatc ttcaagaact tccaggagtg tgtggaccag aaggtgtacc aggctgagat      840

ggacgagctc ccggccgcct tcgtggatgg ctctaagaac ggtggggaca agcacggggc      900

caacagcctg aagatcactg agaaggtgtc aggccagcac gtggagatcc aggccaagta      960

catcggcacc accatcgtgg tgcgccaggt gggccgctac ctgacctttg ccgtccgcat     1020

gccagaggaa gtggtcaatg ctgtggagga ctgggacagc cagggtctct acctctgcct     1080

gcggggctgc cccctcaacc agcagatcga cttccaggcc ttccacacca atgctgaggg     1140

caccggtgcc cgcaggctgg cagccgccag ccctgcaccc acagcccccg agaccttccc     1200

atacgagaca gccgtggcca agtgcaagga gaagctgccg gtggaggacc tgtactacca     1260

ggcctgcgtc ttcgacctcc tcaccacggg cgacgtgaac ttcacactgg ccgcctacta     1320

cgcgttggag gatgtcaaga tgctccactc caacaaagac aaactgcacc tgtatgagag     1380

gactcgggac ctgccaggca gggcggctgc ggggctgccc ctggcccccc ggcccctcct     1440

gggcgccctc gtcccgctcc tggccctgct ccctgtgttc tgctagacgc gtagatgtgg     1500

agggaggcgc gggctccgtc ctctcggctt ccccatgtgt gggctgggac cgcccacggg     1560

gtgcagatct cctggcgtgt ccaccatggc cccgcagaac gccagggacc gcctgctgcc     1620

aagggctcag gcacggaccc ctccccttct agtgcacgtg acaaggttgt ggtgactggt     1680

gccatgatgt ttgacagtag agctgtgtga gagggagagc agctcccctc gccccgcccc     1740

tgcagtgtga atgtgtgaaa catcccctca ggctgaagcc ccccaccccc accagagaca     1800

cactgggaac cgtcagagtc agctccttcc ccctcgcaat gcactgaaag gcccggccga     1860

ctgctgctcg ccgatccgtg gggccccctg tgcccgccac acgcacgcac acactcttac     1920

acgagagcac actcgatccc cctaggccag cggggacacc ccagccacac agggaggcat     1980

ccttggggct tggccccagg cagggcaacc ccggggcgct gcttggcacc ttagcagact     2040

gctggaacct tttggccagt aggtcgtgcc cgcctggtgc cttctggcct gtggcctccc     2100

tgcccatgtt cacctggctg ctgtgggtac cagtgcaggt cccggttttc aggcacctgc     2160

tcagctgccc gtctctggcc tgggcccctg ccccttccac cctgtgctta gaaagtcgaa     2220

gtgcttggtt ctaaatgtct aaacagagaa gagatccttg acttctgttc ctctctctcc     2280

tgcagatgca agagctcctg ggcaggggtg cctgggcccc agggtgtggc aggagaccca     2340

gtggatgggg ccagctggcc tgccctgatc ctctgcttcc tcctcacaac cccaagagcc     2400

cccagcccgg tccatccacg tctggagtct ggggagagga gcagggtctt aggactctca     2460

gctctgagca tccctggcag ggtcttcaac ctctaatctc ttcccttaag ccctgtggcc     2520

acacagccag gagagacttg ccgctggctc ccgcctcatt tcagcccagg gtgctcatcc     2580

aggggcccag aacagtccca cctgtgctgc tgtgcccaca gcacaaagcc aggcttcact     2640

cccaaaagtg cagccaggcc ctggagggtg atcctgccag cagccctaca gctccacacc     2700

ctacccaccc atcggcagcc cctctgctgt tccccaggga cctctcatac actggccagg     2760

aggctgcaga acgtgtgtct ccccctccct ccaagaggtc ctgctccctc tgccagaacc     2820

gtgtgtgggc gggtgggagg gcgctcgggg cccggcccct ccctctccct gctggtttta     2880

gttggtccct atgttggaag taaaaagtga agcactttat tttggttgtg tttgctcacg     2940

ttctgcttgg aagtggggac ccctcactgc gtccacgtgt ctgcgacctg tgtggagtgt     3000

caccgcgtgt acatactgta aattatttat taatggctaa atgcaagtaa agtttggttt     3060

ttttgttatt ttctttta                                                   3078


<210>  19
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gly Met Gly Arg Gly Ala Gly Arg Ser Ala Leu Gly Phe Trp Pro 
1               5                   10                  15      


Thr Leu Ala Phe Leu Leu Cys Ser Phe Pro Ala Ala Thr Ser Pro Cys 
            20                  25                  30          


Lys Ile Leu Lys Cys Asn Ser Glu Phe Trp Ser Ala Thr Ser Gly Ser 
        35                  40                  45              


His Ala Pro Ala Ser Asp Asp Thr Pro Glu Phe Cys Ala Ala Leu Arg 
    50                  55                  60                  


Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly Asp 
65                  70                  75                  80  


Leu Ala Tyr His Ser Ala Val His Gly Ile Glu Asp Leu Met Ser Gln 
                85                  90                  95      


His Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro Arg Leu Arg Thr 
            100                 105                 110         


Leu Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser Asp Ser Pro Glu Ile 
        115                 120                 125             


Cys His Tyr Glu Lys Ser Phe His Lys His Ser Ala Thr Pro Asn Tyr 
    130                 135                 140                 


Thr His Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr Phe Thr Asp 
145                 150                 155                 160 


Arg Phe Gln Thr Cys Lys Val Gln Gly Ala Trp Pro Leu Ile Asp Asn 
                165                 170                 175     


Asn Tyr Leu Asn Val Gln Val Thr Asn Thr Pro Val Leu Pro Gly Ser 
            180                 185                 190         


Ala Ala Thr Ala Thr Ser Lys Leu Thr Ile Ile Phe Lys Asn Phe Gln 
        195                 200                 205             


Glu Cys Val Asp Gln Lys Val Tyr Gln Ala Glu Met Asp Glu Leu Pro 
    210                 215                 220                 


Ala Ala Phe Val Asp Gly Ser Lys Asn Gly Gly Asp Lys His Gly Ala 
225                 230                 235                 240 


Asn Ser Leu Lys Ile Thr Glu Lys Val Ser Gly Gln His Val Glu Ile 
                245                 250                 255     


Gln Ala Lys Tyr Ile Gly Thr Thr Ile Val Val Arg Gln Val Gly Arg 
            260                 265                 270         


Tyr Leu Thr Phe Ala Val Arg Met Pro Glu Glu Val Val Asn Ala Val 
        275                 280                 285             


Glu Asp Trp Asp Ser Gln Gly Leu Tyr Leu Cys Leu Arg Gly Cys Pro 
    290                 295                 300                 


Leu Asn Gln Gln Ile Asp Phe Gln Ala Phe His Thr Asn Ala Glu Gly 
305                 310                 315                 320 


Thr Gly Ala Arg Arg Leu Ala Ala Ala Ser Pro Ala Pro Thr Ala Pro 
                325                 330                 335     


Glu Thr Phe Pro Tyr Glu Thr Ala Val Ala Lys Cys Lys Glu Lys Leu 
            340                 345                 350         


Pro Val Glu Asp Leu Tyr Tyr Gln Ala Cys Val Phe Asp Leu Leu Thr 
        355                 360                 365             


Thr Gly Asp Val Asn Phe Thr Leu Ala Ala Tyr Tyr Ala Leu Glu Asp 
    370                 375                 380                 


Val Lys Met Leu His Ser Asn Lys Asp Lys Leu His Leu Tyr Glu Arg 
385                 390                 395                 400 


Thr Arg Asp Leu Pro Gly Arg Ala Ala Ala Gly Leu Pro Leu Ala Pro 
                405                 410                 415     


Arg Pro Leu Leu Gly Ala Leu Val Pro Leu Leu Ala Leu Leu Pro Val 
            420                 425                 430         


Phe Cys 
        


<210>  20
<211>  454
<212>  PRT
<213>  Mus musculus

<400>  20

Met Gln Pro Pro Arg Glu Arg Leu Val Val Thr Gly Arg Ala Gly Trp 
1               5                   10                  15      


Met Gly Met Gly Arg Gly Ala Gly Arg Ser Ala Leu Gly Leu Trp Pro 
            20                  25                  30          


Thr Leu Ala Phe Leu Leu Cys Ser Phe Pro Ala Ala Ile Ser Pro Cys 
        35                  40                  45              


Lys Ile Leu Lys Cys Asn Ser Glu Phe Trp Ser Ala Thr Ser Ser Gly 
    50                  55                  60                  


Ser His Ala Pro Ala Ser Asp Asp Val Pro Glu Phe Cys Ala Ala Leu 
65                  70                  75                  80  


Arg Thr Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly 
                85                  90                  95      


Asp Leu Ala Tyr His Ser Ala Val His Gly Ile Glu Asp Leu Met Ser 
            100                 105                 110         


Gln His Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro Arg Val Arg 
        115                 120                 125             


Thr Leu Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser Asp Ser Pro Glu 
    130                 135                 140                 


Ile Cys His Tyr Glu Lys Ser Phe His Lys His Ser Ala Ala Pro Asn 
145                 150                 155                 160 


Tyr Thr His Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr Phe Thr 
                165                 170                 175     


Asp His Phe Gln Thr Cys Lys Val Gln Gly Ala Trp Pro Leu Ile Asp 
            180                 185                 190         


Asn Asn Tyr Leu Asn Val Gln Val Thr Asn Thr Pro Val Leu Pro Gly 
        195                 200                 205             


Ser Ala Ala Thr Ala Thr Ser Lys Leu Thr Ile Ile Phe Lys Asn Phe 
    210                 215                 220                 


Gln Glu Cys Val Asp Gln Lys Val Tyr Gln Ala Glu Met Asp Glu Leu 
225                 230                 235                 240 


Pro Ser Ala Phe Ala Asp Gly Ser Lys Asn Gly Gly Asp Lys His Gly 
                245                 250                 255     


Ala Asn Ser Leu Lys Ile Thr Glu Lys Val Ser Gly Gln His Val Glu 
            260                 265                 270         


Ile Gln Ala Lys Tyr Ile Gly Thr Thr Ile Val Val Arg Gln Val Gly 
        275                 280                 285             


Arg Tyr Leu Thr Phe Ala Val Arg Met Pro Glu Glu Val Val Asn Ala 
    290                 295                 300                 


Val Glu Asp Arg Asp Ser Gln Gly Leu Tyr Leu Cys Leu Arg Gly Cys 
305                 310                 315                 320 


Pro Leu Asn Gln Gln Ile Asp Phe Gln Ala Phe Arg Ala Asn Ala Glu 
                325                 330                 335     


Ser Pro Arg Arg Pro Ala Ala Ala Ser Pro Ser Pro Val Val Pro Glu 
            340                 345                 350         


Thr Phe Pro Tyr Glu Thr Ala Val Ala Lys Cys Lys Glu Lys Leu Pro 
        355                 360                 365             


Val Glu Asp Leu Tyr Tyr Gln Ala Cys Val Phe Asp Leu Leu Thr Thr 
    370                 375                 380                 


Gly Asp Val Asn Phe Thr Leu Ala Ala Tyr Tyr Ala Leu Glu Asp Gly 
385                 390                 395                 400 


Lys Met Leu His Ser Asn Lys Asp Lys Leu His Leu Phe Glu Arg Thr 
                405                 410                 415     


Arg Glu Leu Pro Gly Ala Val Ala Ala Ala Ala Ala Ala Ala Thr Thr 
            420                 425                 430         


Phe Pro Leu Ala Pro Gln Ile Leu Leu Gly Thr Ile Pro Leu Leu Val 
        435                 440                 445             


Leu Leu Pro Val Leu Trp 
    450                 


<210>  21
<211>  4601
<212>  DNA
<213>  Homo sapiens

<400>  21
atttgaggct gactggggag aaagctgcct ggaggaagct gctggggtgc ggggggctga       60

gggatttggc tccccgccct ctcccctaga tggcggagaa atcgggctag ctggaagggc      120

gcagctcctc tcccagagct cattctggag tcggagaact gggagagcgg cccccgaggc      180

ggagcctccc tcccgccccg agtcgcgctg ccccccacct gggggagagg ggcgggcgcc      240

gcgctgcctt ccctccgcgc ctcggccgcg tggcttgcgg cttattttcc cagctggcaa      300

gcgtcgcgct gcagacaagg gaatgcctgt ggtcctgcgt gttccgaagt tcaggggccc      360

cctgatcccg ctgagccccc tccaggagcg aaagggttaa gaatgataag gaagaagagg      420

aagcgaagcg cgccccccgg cccatgccgc agccacgggc ccagacccgc cacggcgccc      480

gcgccgccgc cctcgccgga gcccacgaga cctgcatgga cgggcatggg cttgagagca      540

gcaccttcca gcgccgccgc tgccgccgcc gaggttgagc agcgccgcag ccccgggctc      600

tgccccccgc cgctggagct gctgctgctg ctgctgttca gcctcgggct gctccacgca      660

ggtgactgcc aacagccagc ccaatgtcga atccagaaat gcaccacgga cttcgtgtcc      720

ctgacttctc acctgaactc tgccgttgac ggctttgact ctgagttttg caaggccttg      780

cgtgcctatg ctggctgcac ccagcgaact tcaaaagcct gccgtggcaa cctggtatac      840

cattctgccg tgttgggtat cagtgacctc atgagccaga ggaattgttc caaggatgga      900

cccacatcct ctaccaaccc cgaagtgacc catgatcctt gcaactatca cagccacgct      960

ggagccaggg aacacaggag aggggaccag aaccctccca gttacctttt ttgtggcttg     1020

tttggagatc ctcacctcag aactttcaag gataacttcc aaacatgcaa agtagaaggg     1080

gcctggccac tcatagataa taattatctt tcagttcaag tgacaaacgt acctgtggtc     1140

cctggatcca gtgctactgc tacaaataag atcactatta tcttcaaagc ccaccatgag     1200

tgtacagatc agaaagtcta ccaagctgtg acagatgacc tgccggccgc ctttgtggat     1260

ggcaccacca gtggtgggga cagcgatgcc aagagcctgc gtatcgtgga aagggagagt     1320

ggccactatg tggagatgca cgcccgctat atagggacca cagtgtttgt gcggcaggtg     1380

ggtcgctacc tgacccttgc catccgtatg cctgaagacc tggccatgtc ctacgaggag     1440

agccaggacc tgcagctgtg cgtgaacggc tgccccctga gtgaacgcat cgatgacggg     1500

cagggccagg tgtctgccat cctgggacac agcctgcctc gcacctcctt ggtgcaggcc     1560

tggcctggct acacactgga gactgccaac actcaatgcc atgagaagat gccagtgaag     1620

gacatctatt tccagtcctg tgtcttcgac ctgctcacca ctggtgatgc caactttact     1680

gccgcagccc acagtgcctt ggaggatgtg gaggccctgc acccaaggaa ggaacgctgg     1740

cacattttcc ccagcagtgg caatgggact ccccgtggag gcagtgattt gtctgtcagt     1800

ctaggactca cctgcttgat ccttatcgtg tttttgtagg ggttgtcttt tgttttggtt     1860

ttttattttt tgtctataac aaaattttaa aatatatatt gtcataatat attgagtaaa     1920

agagtatata tgtatatacc atgtatatga caggatgttt gtcctgggac acccaccaga     1980

ttgtacatac tgtgtttggc tgttttcaca tatgttggat gtagtgttct ttgattgtat     2040

caattttgtt ttgcagttct gtgaaatgtt ttataatgtc cctgcccagg gacctgttag     2100

aaagcacttt attttttata tattaaatat ttatgtgtgt gcttggttga tatgtatagt     2160

acatatacac agacatccat atgcagcgtt tcctttgaag gtgaccagtt gtttgtagct     2220

attcttggct gtaccttcct gccctttccc attgctactg atttgccacg gtgtgcagct     2280

tttactcgcc accttccggt ggagctgcct cgttcctttg aactatgccc tcacccttct     2340

gccctcactt gatttgaaag ggtcgttaac tctcccttac aggtgctttg actcttaaac     2400

gctgatctta agaagctctc ttcatctaag agctgttact ttttcagaag ggggggtatt     2460

attggtattc tgattactct caattctaat tgttatatat ttgagcccat acagtgtatt     2520

aggttgaacc atagaaactg ctattctcgt aggtcaaaag ggtctagtga tggaagtttt     2580

gtagataagt accaggcatc tcagtaactc ctagactttt tctcatccca tgccccgttt     2640

taaattgtca gttttccctc tgactcttct gtgttaaaac atgaaactat aaatttagta     2700

attatcatgc cttgctcttt ttaatctata tgactgatgc aagcccctct tcttaaccgt     2760

ttcttggctt tgagcccaga aacacagctc tccctgtctc caactccagt aagccctcct     2820

cagcctcacc ttacgaatcc aaagaactgg ggtttgttag gttctttctc taatgtagag     2880

gcccagatcc catcacaaag tttttcattc ttccttgtcc accatgatct tcatcacagt     2940

ctttgatatg tctgcatgca aagtggaaca gagttgggcg gcaatgacag aagagcttcc     3000

ttggcctgac tcggtgtgcg gccacttcgg cactgcttaa tccagatatt cttgttaact     3060

aagcattgtg cttcccaggt ggtctgaagt caggtactct ctctctcaac acctgtagtt     3120

gaatatgatt tggtcagttg ctcgttgtaa cttggagaaa ttcctataaa gtaagatctc     3180

cttgcctctt ccatccattg ttggcacccc cttgcaaaag gaaaagaaca gcaaaagtca     3240

ggagcagtaa tctgagaaag ttaactccag gataggtagg tttctattgt tatagctaga     3300

tgtaaatctt tagttccaag aagtgataga gtttctgctt taataatttg ttgataagtt     3360

tacataaaca gaaataaaag atactatctt taccgtagta gttcaggcca agattatgct     3420

tagttttagt tctccaggta gttacttttg ccatgtccta ttgatcagtg acactgccag     3480

aggcccatac cggcaagagg aagaggacgt cattttgtaa agtttaactt cttagcgaac     3540

tgatgtgcca cccagtcaca gagtggagtt gtgaattcat gtagaggtgg caaacctcta     3600

ccttgtgttg atgagagaat aatcttgggc agtctgggaa aataaggaag gcatctcctt     3660

cttactcatg gagattcaac tatagagagt tgaaacctaa acccgccttc cttttataga     3720

agctggacta gagacggact gaccatcagc tctgaactgt ggcttttttt gttcacctat     3780

gatgccatgt accaaattca gaagctatcg ttaataattt gttttataat tgagtagtac     3840

aagcgaggaa aaaatacgga ggataaccac tatttttgtg caaataatat gaaagtgaag     3900

taaaagcaat agaagaaatt tctataggat ctgggtttag agtgtgtatc attaataaat     3960

atacctttgc tcttttcagg gaaaataaca accaccctta ctgatagttg ggaaaagaag     4020

attgggttat tttgccatat catttagctg gaagtgacat ttaaaagcac cctgcatcac     4080

tagtaatagt gtattttgct attctgccct tgtaatcggt gtccctgtaa aacaatcccc     4140

acagattact ttcagaaata gatgtatttc tctacgtaag ggccaggttt attttctcct     4200

tttttgagat ttctagaaaa aatgctgctt gcacatgttg gttcttgaaa ccttagctag     4260

aagaatttca ggtcatacca acatgtggat aggctatagc tgttcagagg tctcctgggg     4320

gagcttaaaa cgggggaaac actggttttc acagatgctc cacatggctg tctttaaaag     4380

actcaaaact tttttttgtc ctctttgtta tgcttggaag ctcccccccc cccaacagtg     4440

tgtcgagtct ttgcaaagaa acctttagat gtggttcata gatatatgaa tacgtatctg     4500

tgtaaaacag tgagtgtgca gtgtgtaaat actttaaatt attatgctag aaaaataaag     4560

ttacatacct tgctgtggaa aaaaaaaaaa aaaaaaaaaa a                         4601


<210>  22
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ile Arg Lys Lys Arg Lys Arg Ser Ala Pro Pro Gly Pro Cys Arg 
1               5                   10                  15      


Ser His Gly Pro Arg Pro Ala Thr Ala Pro Ala Pro Pro Pro Ser Pro 
            20                  25                  30          


Glu Pro Thr Arg Pro Ala Trp Thr Gly Met Gly Leu Arg Ala Ala Pro 
        35                  40                  45              


Ser Ser Ala Ala Ala Ala Ala Ala Glu Val Glu Gln Arg Arg Ser Pro 
    50                  55                  60                  


Gly Leu Cys Pro Pro Pro Leu Glu Leu Leu Leu Leu Leu Leu Phe Ser 
65                  70                  75                  80  


Leu Gly Leu Leu His Ala Gly Asp Cys Gln Gln Pro Ala Gln Cys Arg 
                85                  90                  95      


Ile Gln Lys Cys Thr Thr Asp Phe Val Ser Leu Thr Ser His Leu Asn 
            100                 105                 110         


Ser Ala Val Asp Gly Phe Asp Ser Glu Phe Cys Lys Ala Leu Arg Ala 
        115                 120                 125             


Tyr Ala Gly Cys Thr Gln Arg Thr Ser Lys Ala Cys Arg Gly Asn Leu 
    130                 135                 140                 


Val Tyr His Ser Ala Val Leu Gly Ile Ser Asp Leu Met Ser Gln Arg 
145                 150                 155                 160 


Asn Cys Ser Lys Asp Gly Pro Thr Ser Ser Thr Asn Pro Glu Val Thr 
                165                 170                 175     


His Asp Pro Cys Asn Tyr His Ser His Ala Gly Ala Arg Glu His Arg 
            180                 185                 190         


Arg Gly Asp Gln Asn Pro Pro Ser Tyr Leu Phe Cys Gly Leu Phe Gly 
        195                 200                 205             


Asp Pro His Leu Arg Thr Phe Lys Asp Asn Phe Gln Thr Cys Lys Val 
    210                 215                 220                 


Glu Gly Ala Trp Pro Leu Ile Asp Asn Asn Tyr Leu Ser Val Gln Val 
225                 230                 235                 240 


Thr Asn Val Pro Val Val Pro Gly Ser Ser Ala Thr Ala Thr Asn Lys 
                245                 250                 255     


Ile Thr Ile Ile Phe Lys Ala His His Glu Cys Thr Asp Gln Lys Val 
            260                 265                 270         


Tyr Gln Ala Val Thr Asp Asp Leu Pro Ala Ala Phe Val Asp Gly Thr 
        275                 280                 285             


Thr Ser Gly Gly Asp Ser Asp Ala Lys Ser Leu Arg Ile Val Glu Arg 
    290                 295                 300                 


Glu Ser Gly His Tyr Val Glu Met His Ala Arg Tyr Ile Gly Thr Thr 
305                 310                 315                 320 


Val Phe Val Arg Gln Val Gly Arg Tyr Leu Thr Leu Ala Ile Arg Met 
                325                 330                 335     


Pro Glu Asp Leu Ala Met Ser Tyr Glu Glu Ser Gln Asp Leu Gln Leu 
            340                 345                 350         


Cys Val Asn Gly Cys Pro Leu Ser Glu Arg Ile Asp Asp Gly Gln Gly 
        355                 360                 365             


Gln Val Ser Ala Ile Leu Gly His Ser Leu Pro Arg Thr Ser Leu Val 
    370                 375                 380                 


Gln Ala Trp Pro Gly Tyr Thr Leu Glu Thr Ala Asn Thr Gln Cys His 
385                 390                 395                 400 


Glu Lys Met Pro Val Lys Asp Ile Tyr Phe Gln Ser Cys Val Phe Asp 
                405                 410                 415     


Leu Leu Thr Thr Gly Asp Ala Asn Phe Thr Ala Ala Ala His Ser Ala 
            420                 425                 430         


Leu Glu Asp Val Glu Ala Leu His Pro Arg Lys Glu Arg Trp His Ile 
        435                 440                 445             


Phe Pro Ser Ser Gly Asn Gly Thr Pro Arg Gly Gly Ser Asp Leu Ser 
    450                 455                 460                 


Val Ser Leu Gly Leu Thr Cys Leu Ile Leu Ile Val Phe Leu 
465                 470                 475             


<210>  23
<211>  436
<212>  PRT
<213>  Mus musculus

<400>  23

Met Gly Val Arg Ala Ala Pro Ser Cys Ala Ala Ala Pro Ala Ala Ala 
1               5                   10                  15      


Gly Ala Glu Gln Ser Arg Arg Pro Gly Leu Trp Pro Pro Ser Pro Pro 
            20                  25                  30          


Pro Pro Leu Leu Leu Leu Leu Leu Leu Ser Leu Gly Leu Leu His Ala 
        35                  40                  45              


Gly Asp Cys Gln Gln Pro Thr Gln Cys Arg Ile Gln Lys Cys Thr Thr 
    50                  55                  60                  


Asp Phe Val Ala Leu Thr Ala His Leu Asn Ser Ala Ala Asp Gly Phe 
65                  70                  75                  80  


Asp Ser Glu Phe Cys Lys Ala Leu Arg Ala Tyr Ala Gly Cys Thr Gln 
                85                  90                  95      


Arg Thr Ser Lys Ala Cys Arg Gly Asn Leu Val Tyr His Ser Ala Val 
            100                 105                 110         


Leu Gly Ile Ser Asp Leu Met Ser Gln Arg Asn Cys Ser Lys Asp Gly 
        115                 120                 125             


Pro Thr Ser Ser Thr Asn Pro Glu Val Thr His Asp Pro Cys Asn Tyr 
    130                 135                 140                 


His Ser His Gly Gly Val Arg Glu His Gly Gly Gly Asp Gln Arg Pro 
145                 150                 155                 160 


Pro Asn Tyr Leu Phe Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr 
                165                 170                 175     


Phe Lys Asp His Phe Gln Thr Cys Lys Val Glu Gly Ala Trp Pro Leu 
            180                 185                 190         


Ile Asp Asn Asn Tyr Leu Ser Val Gln Val Thr Asn Val Pro Val Val 
        195                 200                 205             


Pro Gly Ser Ser Ala Thr Ala Thr Asn Lys Val Thr Ile Ile Phe Lys 
    210                 215                 220                 


Ala Gln His Glu Cys Thr Asp Gln Lys Val Tyr Gln Ala Val Thr Asp 
225                 230                 235                 240 


Asp Leu Pro Ala Ala Phe Val Asp Gly Thr Thr Ser Gly Gly Asp Gly 
                245                 250                 255     


Asp Val Lys Ser Leu His Ile Val Glu Lys Glu Ser Gly Arg Tyr Val 
            260                 265                 270         


Glu Met His Ala Arg Tyr Ile Gly Thr Thr Val Phe Val Arg Gln Leu 
        275                 280                 285             


Gly Arg Tyr Leu Thr Leu Ala Ile Arg Met Pro Glu Asp Leu Ala Met 
    290                 295                 300                 


Ser Tyr Glu Glu Ser Gln Asp Leu Gln Leu Cys Val Asn Gly Cys Pro 
305                 310                 315                 320 


Met Ser Glu Cys Ile Asp Asp Gly Gln Gly Gln Val Ser Ala Ile Leu 
                325                 330                 335     


Gly His Ser Leu Pro His Thr Thr Ser Val Gln Ala Trp Pro Gly Tyr 
            340                 345                 350         


Thr Leu Glu Thr Ala Ser Thr Gln Cys His Glu Lys Met Pro Val Lys 
        355                 360                 365             


Asp Ile Tyr Phe Gln Ser Cys Val Phe Asp Leu Leu Thr Thr Gly Asp 
    370                 375                 380                 


Ala Asn Phe Thr Ala Ala Ala His Ser Ala Leu Glu Asp Val Glu Ala 
385                 390                 395                 400 


Leu His Pro Arg Lys Glu Arg Trp His Ile Phe Pro Ser Ser Cys Gly 
                405                 410                 415     


Gly Cys Arg Asp Leu Pro Val Gly Leu Gly Leu Thr Cys Leu Ile Leu 
            420                 425                 430         


Ile Met Phe Leu 
        435     


