                         SEQUENCE LISTING

<110>  UNIVERSITY OF UTAH RESEARCH FOUNDATION
 
<120>  RON INHIBITORS FOR USE IN PREVENTING AND TREATING BONE LOSS

<130>  026389-9117-WO00

<140>  New PCT International Patent Application
<141>  2015-03-13

<150>  US 61/953,309
<151>  2014-03-14

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1351
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr 
            20                  25                  30          


Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser 
        35                  40                  45              


Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp 
    50                  55                  60                  


Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala 
                85                  90                  95      


Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His 
            100                 105                 110         


Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala 
        115                 120                 125             


Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe 
    130                 135                 140                 


Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro 
145                 150                 155                 160 


Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp 
                165                 170                 175     


Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly 
            180                 185                 190         


Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala 
        195                 200                 205             


Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp 
    210                 215                 220                 


Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys 
225                 230                 235                 240 


His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly 
                245                 250                 255     


Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp 
            260                 265                 270         


Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro 
        275                 280                 285             


Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro 
    290                 295                 300                 


Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val 
305                 310                 315                 320 


Leu Arg Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu 
                325                 330                 335     


Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr 
            340                 345                 350         


Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala 
        355                 360                 365             


Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg 
    370                 375                 380                 


Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe 
385                 390                 395                 400 


Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu 
                405                 410                 415     


Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser 
            420                 425                 430         


Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val 
        435                 440                 445             


Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met 
    450                 455                 460                 


Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu 
465                 470                 475                 480 


Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln 
                485                 490                 495     


Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala 
            500                 505                 510         


Ser Gly Asp Gln Val Phe Gln Val Pro Ile Gln Gly Pro Gly Cys Arg 
        515                 520                 525             


His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly 
    530                 535                 540                 


Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly 
545                 550                 555                 560 


Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro 
                565                 570                 575     


His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser 
            580                 585                 590         


Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln 
        595                 600                 605             


Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser 
    610                 615                 620                 


Lys Leu Arg Pro Val Pro Arg Lys Asp Phe Val Glu Glu Phe Glu Cys 
625                 630                 635                 640 


Glu Leu Glu Pro Leu Gly Thr Gln Ala Val Gly Pro Thr Asn Val Ser 
                645                 650                 655     


Leu Thr Val Thr Asn Met Pro Pro Gly Lys His Phe Arg Val Asp Gly 
            660                 665                 670         


Thr Ser Val Leu Arg Gly Phe Ser Phe Met Glu Pro Val Leu Ile Ala 
        675                 680                 685             


Val Gln Pro Leu Phe Gly Pro Arg Ala Gly Gly Thr Cys Leu Thr Leu 
    690                 695                 700                 


Glu Gly Gln Ser Leu Ser Val Gly Thr Ser Arg Ala Val Leu Val Asn 
705                 710                 715                 720 


Gly Thr Glu Cys Leu Leu Ala Arg Val Ser Glu Gly Gln Leu Leu Cys 
                725                 730                 735     


Ala Thr Pro Pro Gly Ala Thr Val Ala Ser Val Pro Leu Ser Leu Gln 
            740                 745                 750         


Val Gly Gly Ala Gln Val Pro Gly Ser Trp Thr Phe Gln Tyr Arg Glu 
        755                 760                 765             


Asp Pro Val Val Leu Ser Ile Ser Pro Asn Cys Gly Tyr Ile Asn Ser 
    770                 775                 780                 


His Ile Thr Ile Cys Gly Gln His Leu Thr Ser Ala Trp His Leu Val 
785                 790                 795                 800 


Leu Ser Phe His Asp Gly Leu Arg Ala Val Glu Ser Arg Cys Glu Arg 
                805                 810                 815     


Gln Leu Pro Glu Gln Gln Leu Cys Arg Leu Pro Glu Tyr Val Val Arg 
            820                 825                 830         


Asp Pro Gln Gly Trp Val Ala Gly Asn Leu Ser Ala Arg Gly Asp Gly 
        835                 840                 845             


Ala Ala Gly Phe Thr Leu Pro Gly Phe Arg Phe Leu Pro Pro Pro His 
    850                 855                 860                 


Pro Pro Ser Ala Asn Leu Val Pro Leu Lys Pro Glu Glu His Ala Ile 
865                 870                 875                 880 


Lys Phe Glu Val Cys Val Asp Gly Glu Cys His Ile Leu Gly Arg Val 
                885                 890                 895     


Val Arg Pro Gly Pro Asp Gly Val Pro Gln Ser Thr Leu Leu Gly Ile 
            900                 905                 910         


Leu Leu Pro Leu Leu Leu Leu Val Ala Ala Leu Ala Thr Ala Leu Val 
        915                 920                 925             


Phe Ser Tyr Trp Trp Arg Arg Lys Gln Leu Val Leu Pro Pro Asn Leu 
    930                 935                 940                 


Asn Asp Leu Ala Ser Leu Asp Gln Thr Ala Gly Ala Thr Pro Leu Pro 
945                 950                 955                 960 


Ile Leu Tyr Ser Gly Ser Asp Tyr Arg Ser Gly Leu Ala Leu Pro Ala 
                965                 970                 975     


Ile Asp Gly Leu Asp Ser Thr Thr Cys Val His Gly Ala Ser Phe Ser 
            980                 985                 990         


Asp Ser Glu Asp Glu Ser Cys Val  Pro Leu Leu Arg Lys  Glu Ser Ile 
        995                 1000                 1005             


Gln Leu  Arg Asp Leu Asp Ser  Ala Leu Leu Ala Glu  Val Lys Asp 
    1010                 1015                 1020             


Val Leu  Ile Pro His Glu Arg  Val Val Thr His Ser  Asp Arg Val 
    1025                 1030                 1035             


Ile Gly  Lys Gly His Phe Gly  Val Val Tyr His Gly  Glu Tyr Ile 
    1040                 1045                 1050             


Asp Gln  Ala Gln Asn Arg Ile  Gln Cys Ala Ile Lys  Ser Leu Ser 
    1055                 1060                 1065             


Arg Ile  Thr Glu Met Gln Gln  Val Glu Ala Phe Leu  Arg Glu Gly 
    1070                 1075                 1080             


Leu Leu  Met Arg Gly Leu Asn  His Pro Asn Val Leu  Ala Leu Ile 
    1085                 1090                 1095             


Gly Ile  Met Leu Pro Pro Glu  Gly Leu Pro His Val  Leu Leu Pro 
    1100                 1105                 1110             


Tyr Met  Cys His Gly Asp Leu  Leu Gln Phe Ile Arg  Ser Pro Gln 
    1115                 1120                 1125             


Arg Asn  Pro Thr Val Lys Asp  Leu Ile Ser Phe Gly  Leu Gln Val 
    1130                 1135                 1140             


Ala Arg  Gly Met Glu Tyr Leu  Ala Glu Gln Lys Phe  Val His Arg 
    1145                 1150                 1155             


Asp Leu  Ala Ala Arg Asn Cys  Met Leu Asp Glu Ser  Phe Thr Val 
    1160                 1165                 1170             


Lys Val  Ala Asp Phe Gly Leu  Ala Arg Asp Ile Leu  Asp Arg Glu 
    1175                 1180                 1185             


Tyr Tyr  Ser Val Gln Gln His  Arg His Ala Arg Leu  Pro Val Lys 
    1190                 1195                 1200             


Trp Met  Ala Leu Glu Ser Leu  Gln Thr Tyr Arg Phe  Thr Thr Lys 
    1205                 1210                 1215             


Ser Asp  Val Trp Ser Phe Gly  Val Leu Leu Trp Glu  Leu Leu Thr 
    1220                 1225                 1230             


Arg Gly  Ala Pro Pro Tyr Arg  His Ile Asp Pro Phe  Asp Leu Thr 
    1235                 1240                 1245             


His Phe  Leu Ala Gln Gly Arg  Arg Leu Pro Gln Pro  Glu Tyr Cys 
    1250                 1255                 1260             


Pro Asp  Ser Leu Tyr Gln Val  Met Gln Gln Cys Trp  Glu Ala Asp 
    1265                 1270                 1275             


Pro Ala  Val Arg Pro Thr Phe  Arg Val Leu Val Gly  Glu Val Glu 
    1280                 1285                 1290             


Gln Ile  Val Ser Ala Leu Leu  Gly Asp His Tyr Val  Gln Leu Pro 
    1295                 1300                 1305             


Ala Thr  Tyr Met Asn Leu Gly  Pro Ser Thr Ser His  Glu Met Asn 
    1310                 1315                 1320             


Val Arg  Pro Glu Gln Pro Gln  Phe Ser Pro Met Pro  Gly Asn Val 
    1325                 1330                 1335             


Arg Arg  Pro Arg Pro Leu Ser  Glu Pro Pro Arg Pro  Thr 
    1340                 1345                 1350     


<210>  2
<211>  4638
<212>  DNA
<213>  Homo sapiens

<400>  2
agtgtacagc ggcggctggg gcggcaggtg aggcggctgg ggcgttgctg tcgtgcgtcc       60

gcaggcgtca ggtgctcaga cccgagggcc gggaagggat ttgggtttca caggaacctg      120

gggcgggggt ccgctatctt ggggctgtcg ggaccgctgc ttaaatttgg cccagtccag      180

acctcgagtc gggcccccag ccaggcccac gcccaggtcc aggcccaggc cggtagggat      240

cctctagggt cccagctcgc ctcgatggag ctcctcccgc cgctgcctca gtccttcctg      300

ttgctgctgc tgttgcctgc caagcccgcg gcgggcgagg actggcagtg cccgcgcacc      360

ccctacgcgg cctctcgcga ctttgacgtg aagtacgtgg tgcccagctt ctccgccgga      420

ggcctggtac aggccatggt gacctacgag ggcgacagaa atgagagtgc tgtgtttgta      480

gccatacgca atcgcctgca tgtgcttggg cctgacctga agtctgtcca gagcctggcc      540

acgggccctg ctggagaccc tggctgccag acgtgtgcag cctgtggccc aggaccccac      600

ggccctcccg gtgacacaga cacaaaggtg ctggtgctgg atcccgcgct gcctgcgctg      660

gtcagttgtg gctccagcct gcagggccgc tgcttcctgc atgacctaga gccccaaggg      720

acagccgtgc atctggcagc gccagcctgc ctcttctcag cccaccataa ccggcccgat      780

gactgccccg actgtgtggc cagcccattg ggcacccgtg taactgtggt tgagcaaggc      840

caggcctcct atttctacgt ggcatcctca ctggacgcag ccgtggctgc cagcttcagc      900

ccacgctcag tgtctatcag gcgtctcaag gctgacgcct cgggattcgc accgggcttt      960

gtggcgttgt cagtgctgcc caagcatctt gtctcctaca gtattgaata cgtgcacagc     1020

ttccacacgg gagccttcgt atacttcctg actgtacagc cggccagcgt gacagatgat     1080

cctagtgccc tgcacacacg cctggcacgg cttagcgcca ctgagccaga gttgggtgac     1140

tatcgggagc tggtcctcga ctgcagattt gctccaaaac gcaggcgccg gggggcccca     1200

gaaggcggac agccctaccc tgtgctgcgg gtggcccact ccgctccagt gggtgcccaa     1260

cttgccactg agctgagcat cgccgagggc caggaagtac tatttggggt ctttgtgact     1320

ggcaaggatg gtggtcctgg cgtgggcccc aactctgtcg tctgtgcctt ccccattgac     1380

ctgctggaca cactaattga tgagggtgtg gagcgctgtt gtgaatcccc agtccatcca     1440

ggcctccggc gaggcctcga cttcttccag tcgcccagtt tttgccccaa cccgcctggc     1500

ctggaagccc tcagccccaa caccagctgc cgccacttcc ctctgctggt cagtagcagc     1560

ttctcacgtg tggacctatt caatgggctg ttgggaccag tacaggtcac tgcattgtat     1620

gtgacacgcc ttgacaacgt cacagtggca cacatgggca caatggatgg gcgtatcctg     1680

caggtggagc tggtcaggtc actaaactac ttgctgtatg tgtccaactt ctcactgggt     1740

gacagtgggc agcccgtgca gcgggatgtc agtcgtcttg gggaccacct actctttgcc     1800

tctggggacc aggttttcca ggtacctatc caaggccctg gctgccgcca cttcctgacc     1860

tgtgggcgtt gcctaagggc atggcatttc atgggctgtg gctggtgtgg gaacatgtgc     1920

ggccagcaga aggagtgtcc tggctcctgg caacaggacc actgcccacc taagcttact     1980

gagttccacc cccacagtgg acctctaagg ggcagtacaa ggctgaccct gtgtggctcc     2040

aacttctacc ttcacccttc tggtctggtg cctgagggaa cccatcaggt cactgtgggc     2100

caaagtccct gccggccact gcccaaggac agctcaaaac tcagaccagt gccccggaaa     2160

gactttgtag aggagtttga gtgtgaactg gagcccttgg gcacccaggc agtggggcct     2220

accaacgtca gcctcaccgt gactaacatg ccaccgggca agcacttccg ggtagacggc     2280

acctccgtgc tgagaggctt ctctttcatg gagccagtgc tgatagcagt gcaacccctc     2340

tttggcccac gggcaggagg cacctgtctc actcttgaag gccagagtct gtctgtaggc     2400

accagccggg ctgtgctggt caatgggact gagtgtctgc tagcacgggt cagtgagggg     2460

cagcttttat gtgccacacc ccctggggcc acggtggcca gtgtccccct tagcctgcag     2520

gtggggggtg cccaggtacc tggttcctgg accttccagt acagagaaga ccctgtcgtg     2580

ctaagcatca gccccaactg tggctacatc aactcccaca tcaccatctg tggccagcat     2640

ctaacttcag catggcactt agtgctgtca ttccatgacg ggcttagggc agtggaaagc     2700

aggtgtgaga ggcagcttcc agagcagcag ctgtgccgcc ttcctgaata tgtggtccga     2760

gacccccagg gatgggtggc agggaatctg agtgcccgag gggatggagc tgctggcttt     2820

acactgcctg gctttcgctt cctaccccca ccccatccac ccagtgccaa cctagttcca     2880

ctgaagcctg aggagcatgc cattaagttt gaggtctgcg tagatggtga atgtcatatc     2940

ctgggtagag tggtgcggcc agggccagat ggggtcccac agagcacgct ccttggtatc     3000

ctgctgcctt tgctgctgct tgtggctgca ctggcgactg cactggtctt cagctactgg     3060

tggcggagga agcagctagt tcttcctccc aacctgaatg acctggcatc cctggaccag     3120

actgctggag ccacacccct gcctattctg tactcgggct ctgactacag aagtggcctt     3180

gcactccctg ccattgatgg tctggattcc accacttgtg tccatggagc atccttctcc     3240

gatagtgaag atgaatcctg tgtgccactg ctgcggaaag agtccatcca gctaagggac     3300

ctggactctg cgctcttggc tgaggtcaag gatgtgctga ttccccatga gcgggtggtc     3360

acccacagtg accgagtcat tggcaaaggc cactttggag ttgtctacca cggagaatac     3420

atagaccagg cccagaatcg aatccaatgt gccatcaagt cactaagtcg catcacagag     3480

atgcagcagg tggaggcctt cctgcgagag gggctgctca tgcgtggcct gaaccacccg     3540

aatgtgctgg ctctcattgg tatcatgttg ccacctgagg gcctgcccca tgtgctgctg     3600

ccctatatgt gccacggtga cctgctccag ttcatccgct cacctcagcg gaaccccacc     3660

gtgaaggacc tcatcagctt tggcctgcag gtagcccgcg gcatggagta cctggcagag     3720

cagaagtttg tgcacaggga cctggctgcg cggaactgca tgctggacga gtcattcaca     3780

gtcaaggtgg ctgactttgg tttggcccgc gacatcctgg acagggagta ctatagtgtt     3840

caacagcatc gccacgctcg cctacctgtg aagtggatgg cgctggagag cctgcagacc     3900

tatagattta ccaccaagtc tgatgtgtgg tcatttggtg tgctgctgtg ggaactgctg     3960

acacggggtg ccccaccata ccgccacatt gacccttttg accttaccca cttcctggcc     4020

cagggtcggc gcctgcccca gcctgagtat tgccctgatt ctctgtacca agtgatgcag     4080

caatgctggg aggcagaccc agcagtgcga cccaccttca gagtactagt gggggaggtg     4140

gagcagatag tgtctgcact gcttggggac cattatgtgc agctgccagc aacctacatg     4200

aacttgggcc ccagcacctc gcatgagatg aatgtgcgtc cagaacagcc gcagttctca     4260

cccatgccag ggaatgtacg ccggccccgg ccactctcag agcctcctcg gcccacttga     4320

cttagttctt gggctggacc tgcttagctg ccttgagcta accccaagct gcctctgggc     4380

catgccaggc cagagggcag tggccctcca ccttgttcct gccctttaac tttcagaggc     4440

aataggtaaa tggggcccat taggtccctc actccacaga gtgagccagt gagggcagtc     4500

ctgcaacatg tatttatgga gtgcctgctg tggaccctgt cttctgggca cagtggactc     4560

agcagtgacc acaccaacac tgacccttga accaataaag gaacaaatga ctattaaagc     4620

acaaaaaaaa aaaaaaaa                                                   4638


<210>  3
<211>  1390
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
    930                 935                 940                 


Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
945                 950                 955                 960 


Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                965                 970                 975     


Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
            980                 985                 990         


Thr Glu Met Val Ser Asn Glu Ser  Val Asp Tyr Arg Ala  Thr Phe Pro 
        995                 1000                 1005             


Glu Asp  Gln Phe Pro Asn Ser  Ser Gln Asn Gly Ser  Cys Arg Gln 
    1010                 1015                 1020             


Val Gln  Tyr Pro Leu Thr Asp  Met Ser Pro Ile Leu  Thr Ser Gly 
    1025                 1030                 1035             


Asp Ser  Asp Ile Ser Ser Pro  Leu Leu Gln Asn Thr  Val His Ile 
    1040                 1045                 1050             


Asp Leu  Ser Ala Leu Asn Pro  Glu Leu Val Gln Ala  Val Gln His 
    1055                 1060                 1065             


Val Val  Ile Gly Pro Ser Ser  Leu Ile Val His Phe  Asn Glu Val 
    1070                 1075                 1080             


Ile Gly  Arg Gly His Phe Gly  Cys Val Tyr His Gly  Thr Leu Leu 
    1085                 1090                 1095             


Asp Asn  Asp Gly Lys Lys Ile  His Cys Ala Val Lys  Ser Leu Asn 
    1100                 1105                 1110             


Arg Ile  Thr Asp Ile Gly Glu  Val Ser Gln Phe Leu  Thr Glu Gly 
    1115                 1120                 1125             


Ile Ile  Met Lys Asp Phe Ser  His Pro Asn Val Leu  Ser Leu Leu 
    1130                 1135                 1140             


Gly Ile  Cys Leu Arg Ser Glu  Gly Ser Pro Leu Val  Val Leu Pro 
    1145                 1150                 1155             


Tyr Met  Lys His Gly Asp Leu  Arg Asn Phe Ile Arg  Asn Glu Thr 
    1160                 1165                 1170             


His Asn  Pro Thr Val Lys Asp  Leu Ile Gly Phe Gly  Leu Gln Val 
    1175                 1180                 1185             


Ala Lys  Gly Met Lys Tyr Leu  Ala Ser Lys Lys Phe  Val His Arg 
    1190                 1195                 1200             


Asp Leu  Ala Ala Arg Asn Cys  Met Leu Asp Glu Lys  Phe Thr Val 
    1205                 1210                 1215             


Lys Val  Ala Asp Phe Gly Leu  Ala Arg Asp Met Tyr  Asp Lys Glu 
    1220                 1225                 1230             


Tyr Tyr  Ser Val His Asn Lys  Thr Gly Ala Lys Leu  Pro Val Lys 
    1235                 1240                 1245             


Trp Met  Ala Leu Glu Ser Leu  Gln Thr Gln Lys Phe  Thr Thr Lys 
    1250                 1255                 1260             


Ser Asp  Val Trp Ser Phe Gly  Val Leu Leu Trp Glu  Leu Met Thr 
    1265                 1270                 1275             


Arg Gly  Ala Pro Pro Tyr Pro  Asp Val Asn Thr Phe  Asp Ile Thr 
    1280                 1285                 1290             


Val Tyr  Leu Leu Gln Gly Arg  Arg Leu Leu Gln Pro  Glu Tyr Cys 
    1295                 1300                 1305             


Pro Asp  Pro Leu Tyr Glu Val  Met Leu Lys Cys Trp  His Pro Lys 
    1310                 1315                 1320             


Ala Glu  Met Arg Pro Ser Phe  Ser Glu Leu Val Ser  Arg Ile Ser 
    1325                 1330                 1335             


Ala Ile  Phe Ser Thr Phe Ile  Gly Glu His Tyr Val  His Val Asn 
    1340                 1345                 1350             


Ala Thr  Tyr Val Asn Val Lys  Cys Val Ala Pro Tyr  Pro Ser Leu 
    1355                 1360                 1365             


Leu Ser  Ser Glu Asp Asn Ala  Asp Asp Glu Val Asp  Thr Arg Pro 
    1370                 1375                 1380             


Ala Ser  Phe Trp Glu Thr Ser  
    1385                 1390 


<210>  4
<211>  6641
<212>  DNA
<213>  Homo sapiens

<400>  4
gccctcgccg cccgcggcgc cccgagcgct ttgtgagcag atgcggagcc gagtggaggg       60

cgcgagccag atgcggggcg acagctgact tgctgagagg aggcggggag gcgcggagcg      120

cgcgtgtggt ccttgcgccg ctgacttctc cactggttcc tgggcaccga aagataaacc      180

tctcataatg aaggcccccg ctgtgcttgc acctggcatc ctcgtgctcc tgtttacctt      240

ggtgcagagg agcaatgggg agtgtaaaga ggcactagca aagtccgaga tgaatgtgaa      300

tatgaagtat cagcttccca acttcaccgc ggaaacaccc atccagaatg tcattctaca      360

tgagcatcac attttccttg gtgccactaa ctacatttat gttttaaatg aggaagacct      420

tcagaaggtt gctgagtaca agactgggcc tgtgctggaa cacccagatt gtttcccatg      480

tcaggactgc agcagcaaag ccaatttatc aggaggtgtt tggaaagata acatcaacat      540

ggctctagtt gtcgacacct actatgatga tcaactcatt agctgtggca gcgtcaacag      600

agggacctgc cagcgacatg tctttcccca caatcatact gctgacatac agtcggaggt      660

tcactgcata ttctccccac agatagaaga gcccagccag tgtcctgact gtgtggtgag      720

cgccctggga gccaaagtcc tttcatctgt aaaggaccgg ttcatcaact tctttgtagg      780

caataccata aattcttctt atttcccaga tcatccattg cattcgatat cagtgagaag      840

gctaaaggaa acgaaagatg gttttatgtt tttgacggac cagtcctaca ttgatgtttt      900

acctgagttc agagattctt accccattaa gtatgtccat gcctttgaaa gcaacaattt      960

tatttacttc ttgacggtcc aaagggaaac tctagatgct cagacttttc acacaagaat     1020

aatcaggttc tgttccataa actctggatt gcattcctac atggaaatgc ctctggagtg     1080

tattctcaca gaaaagagaa aaaagagatc cacaaagaag gaagtgttta atatacttca     1140

ggctgcgtat gtcagcaagc ctggggccca gcttgctaga caaataggag ccagcctgaa     1200

tgatgacatt cttttcgggg tgttcgcaca aagcaagcca gattctgccg aaccaatgga     1260

tcgatctgcc atgtgtgcat tccctatcaa atatgtcaac gacttcttca acaagatcgt     1320

caacaaaaac aatgtgagat gtctccagca tttttacgga cccaatcatg agcactgctt     1380

taataggaca cttctgagaa attcatcagg ctgtgaagcg cgccgtgatg aatatcgaac     1440

agagtttacc acagctttgc agcgcgttga cttattcatg ggtcaattca gcgaagtcct     1500

cttaacatct atatccacct tcattaaagg agacctcacc atagctaatc ttgggacatc     1560

agagggtcgc ttcatgcagg ttgtggtttc tcgatcagga ccatcaaccc ctcatgtgaa     1620

ttttctcctg gactcccatc cagtgtctcc agaagtgatt gtggagcata cattaaacca     1680

aaatggctac acactggtta tcactgggaa gaagatcacg aagatcccat tgaatggctt     1740

gggctgcaga catttccagt cctgcagtca atgcctctct gccccaccct ttgttcagtg     1800

tggctggtgc cacgacaaat gtgtgcgatc ggaggaatgc ctgagcggga catggactca     1860

acagatctgt ctgcctgcaa tctacaaggt tttcccaaat agtgcacccc ttgaaggagg     1920

gacaaggctg accatatgtg gctgggactt tggatttcgg aggaataata aatttgattt     1980

aaagaaaact agagttctcc ttggaaatga gagctgcacc ttgactttaa gtgagagcac     2040

gatgaataca ttgaaatgca cagttggtcc tgccatgaat aagcatttca atatgtccat     2100

aattatttca aatggccacg ggacaacaca atacagtaca ttctcctatg tggatcctgt     2160

aataacaagt atttcgccga aatacggtcc tatggctggt ggcactttac ttactttaac     2220

tggaaattac ctaaacagtg ggaattctag acacatttca attggtggaa aaacatgtac     2280

tttaaaaagt gtgtcaaaca gtattcttga atgttatacc ccagcccaaa ccatttcaac     2340

tgagtttgct gttaaattga aaattgactt agccaaccga gagacaagca tcttcagtta     2400

ccgtgaagat cccattgtct atgaaattca tccaaccaaa tcttttatta gtggtgggag     2460

cacaataaca ggtgttggga aaaacctgaa ttcagttagt gtcccgagaa tggtcataaa     2520

tgtgcatgaa gcaggaagga actttacagt ggcatgtcaa catcgctcta attcagagat     2580

aatctgttgt accactcctt ccctgcaaca gctgaatctg caactccccc tgaaaaccaa     2640

agcctttttc atgttagatg ggatcctttc caaatacttt gatctcattt atgtacataa     2700

tcctgtgttt aagccttttg aaaagccagt gatgatctca atgggcaatg aaaatgtact     2760

ggaaattaag ggaaatgata ttgaccctga agcagttaaa ggtgaagtgt taaaagttgg     2820

aaataagagc tgtgagaata tacacttaca ttctgaagcc gttttatgca cggtccccaa     2880

tgacctgctg aaattgaaca gcgagctaaa tatagagtgg aagcaagcaa tttcttcaac     2940

cgtccttgga aaagtaatag ttcaaccaga tcagaatttc acaggattga ttgctggtgt     3000

tgtctcaata tcaacagcac tgttattact acttgggttt ttcctgtggc tgaaaaagag     3060

aaagcaaatt aaagatctgg gcagtgaatt agttcgctac gatgcaagag tacacactcc     3120

tcatttggat aggcttgtaa gtgcccgaag tgtaagccca actacagaaa tggtttcaaa     3180

tgaatctgta gactaccgag ctacttttcc agaagatcag tttcctaatt catctcagaa     3240

cggttcatgc cgacaagtgc agtatcctct gacagacatg tcccccatcc taactagtgg     3300

ggactctgat atatccagtc cattactgca aaatactgtc cacattgacc tcagtgctct     3360

aaatccagag ctggtccagg cagtgcagca tgtagtgatt gggcccagta gcctgattgt     3420

gcatttcaat gaagtcatag gaagagggca ttttggttgt gtatatcatg ggactttgtt     3480

ggacaatgat ggcaagaaaa ttcactgtgc tgtgaaatcc ttgaacagaa tcactgacat     3540

aggagaagtt tcccaatttc tgaccgaggg aatcatcatg aaagatttta gtcatcccaa     3600

tgtcctctcg ctcctgggaa tctgcctgcg aagtgaaggg tctccgctgg tggtcctacc     3660

atacatgaaa catggagatc ttcgaaattt cattcgaaat gagactcata atccaactgt     3720

aaaagatctt attggctttg gtcttcaagt agccaaaggc atgaaatatc ttgcaagcaa     3780

aaagtttgtc cacagagact tggctgcaag aaactgtatg ctggatgaaa aattcacagt     3840

caaggttgct gattttggtc ttgccagaga catgtatgat aaagaatact atagtgtaca     3900

caacaaaaca ggtgcaaagc tgccagtgaa gtggatggct ttggaaagtc tgcaaactca     3960

aaagtttacc accaagtcag atgtgtggtc ctttggcgtg ctcctctggg agctgatgac     4020

aagaggagcc ccaccttatc ctgacgtaaa cacctttgat ataactgttt acttgttgca     4080

agggagaaga ctcctacaac ccgaatactg cccagacccc ttatatgaag taatgctaaa     4140

atgctggcac cctaaagccg aaatgcgccc atccttttct gaactggtgt cccggatatc     4200

agcgatcttc tctactttca ttggggagca ctatgtccat gtgaacgcta cttatgtgaa     4260

cgtaaaatgt gtcgctccgt atccttctct gttgtcatca gaagataacg ctgatgatga     4320

ggtggacaca cgaccagcct ccttctggga gacatcatag tgctagtact atgtcaaagc     4380

aacagtccac actttgtcca atggtttttt cactgcctga cctttaaaag gccatcgata     4440

ttctttgctc ttgccaaaat tgcactatta taggacttgt attgttattt aaattactgg     4500

attctaagga atttcttatc tgacagagca tcagaaccag aggcttggtc ccacaggcca     4560

cggaccaatg gcctgcagcc gtgacaacac tcctgtcata ttggagtcca aaacttgaat     4620

tctgggttga attttttaaa aatcaggtac cacttgattt catatgggaa attgaagcag     4680

gaaatattga gggcttcttg atcacagaaa actcagaaga gatagtaatg ctcaggacag     4740

gagcggcagc cccagaacag gccactcatt tagaattcta gtgtttcaaa acacttttgt     4800

gtgttgtatg gtcaataaca tttttcatta ctgatggtgt cattcaccca ttaggtaaac     4860

attccctttt aaatgtttgt ttgttttttg agacaggatc tcactctgtt gccagggctg     4920

tagtgcagtg gtgtgatcat agctcactgc aacctccacc tcccaggctc aagcctcccg     4980

aatagctggg actacaggcg cacaccacca tccccggcta atttttgtat tttttgtaga     5040

gacggggttt tgccatgttg ccaaggctgg tttcaaactc ctggactcaa gaaatccacc     5100

cacctcagcc tcccaaagtg ctaggattac aggcatgagc cactgcgccc agcccttata     5160

aatttttgta tagacattcc tttggttgga agaatattta taggcaatac agtcaaagtt     5220

tcaaaatagc atcacacaaa acatgtttat aaatgaacag gatgtaatgt acatagatga     5280

cattaagaaa atttgtatga aataatttag tcatcatgaa atatttagtt gtcatataaa     5340

aacccactgt ttgagaatga tgctactctg atctaatgaa tgtgaacatg tagatgtttt     5400

gtgtgtattt ttttaaatga aaactcaaaa taagacaagt aatttgttga taaatatttt     5460

taaagataac tcagcatgtt tgtaaagcag gatacatttt actaaaaggt tcattggttc     5520

caatcacagc tcataggtag agcaaagaaa gggtggatgg attgaaaaga ttagcctctg     5580

tctcggtggc aggttcccac ctcgcaagca attggaaaca aaacttttgg ggagttttat     5640

tttgcattag ggtgtgtttt atgttaagca aaacatactt tagaaacaaa tgaaaaaggc     5700

aattgaaaat cccagctatt tcacctagat ggaatagcca ccctgagcag aactttgtga     5760

tgcttcattc tgtggaattt tgtgcttgct actgtatagt gcatgtggtg taggttactc     5820

taactggttt tgtcgacgta aacatttaaa gtgttatatt ttttataaaa atgtttattt     5880

ttaatgatat gagaaaaatt ttgttaggcc acaaaaacac tgcactgtga acattttaga     5940

aaaggtatgt cagactggga ttaatgacag catgattttc aatgactgta aattgcgata     6000

aggaaatgta ctgattgcca atacacccca ccctcattac atcatcagga cttgaagcca     6060

agggttaacc cagcaagcta caaagagggt gtgtcacact gaaactcaat agttgagttt     6120

ggctgttgtt gcaggaaaat gattataact aaaagctctc tgatagtgca gagacttacc     6180

agaagacaca aggaattgta ctgaagagct attacaatcc aaatattgcc gtttcataaa     6240

tgtaataagt aatactaatt cacagagtat tgtaaatggt ggatgacaaa agaaaatctg     6300

ctctgtggaa agaaagaact gtctctacca gggtcaagag catgaacgca tcaatagaaa     6360

gaactcgggg aaacatccca tcaacaggac tacacacttg tatatacatt cttgagaaca     6420

ctgcaatgtg aaaatcacgt ttgctattta taaacttgtc cttagattaa tgtgtctgga     6480

cagattgtgg gagtaagtga ttcttctaag aattagatac ttgtcactgc ctatacctgc     6540

agctgaactg aatggtactt cgtatgttaa tagttgttct gataaatcat gcaattaaag     6600

taaagtgatg caacatcttg taaaaaaaaa aaaaaaaaaa a                         6641


