                         SEQUENCE LISTING

<110>  Rhode Island Hospital
 
<120>  Nanocarriers and their Processing for Diagnostics and 
       Therapeutics

<130>  21486-622001WO

<140>  not yet assigned
<141>  2015-03-16

<150>  61/953495
<151>  2014-03-04

<150>  62/113335
<151>  2015-02-06

<160>  227   

<170>  PatentIn version 3.5

<210>  1
<211>  9663
<212>  DNA
<213>  Homo sapiens

<400>  1
ataaattcat tgttccacct cctcgcatct tcacagcgct cgcgctgctc tcggcgctcg       60

cagctgccga ctggggatga cggcgggcag gaggagaccg cagccgaagg gacacagaca      120

cgccgcttca ccagctcgcc tcaggctgcc cccctgcatt tttgttttaa tttttacggc      180

tttttcccct ctctttcttc ccttcctcct ggtcccagca gagccaagga aacccacaaa      240

ataagaaagg aagtgggccc cggagcttgg aacctccaca gccggcttgt ccagcgcagc      300

gcgggggcgg gaggctgcgc gcaccagttg ccagcccggt gcgcggtacc tttccttact      360

tttcttgaaa cagcgatcgt gcctgcattt ggtggttttt tggtttttgt ttttttcctt      420

ttcccgtatt tgctgaatct ccactatccg actttttttt tttaatcttt tctttccccc      480

cccccccacc ccacctcttt ctggagcacg aatccaaaca ttttcccaag caacaaagaa      540

aagttcgcac gctggcaccg cagcccggac aggctggcgc tgctgccggg cccccctccc      600

tccgacactt gactcaatcc tgcaagcaag tgtgtgtgtg tccccatccc ccgccccgtt      660

aacttcatag caaataacaa atacccataa agtcccagtc gcgcagcccc tccccgcggg      720

cagcgcacta tgctgctcgg gtgggcgtcc ctgctgctgt gcgcgttccg cctgcccctg      780

gccgcggtcg gccccgccgc gacacctgcc caggataaag ccgggcagcc tccgactgct      840

gcagcagccg cccagccccg ccggcggcag ggggaggagg tgcaggagcg agccgagcct      900

cccggccacc cgcaccccct ggcgcagcgg cgcaggagca aggggctggt gcagaacatc      960

gaccaactct actccggcgg cggcaaggtg ggctacctcg tctacgcggg cggccggagg     1020

ttcctcttgg acctggagcg agatggttcg gtgggcattg ctggcttcgt gcccgcagga     1080

ggcgggacga gtgcgccctg gcgccaccgg agccactgct tctatcgggg cacagtggac     1140

ggtagtcccc gctctctggc tgtctttgac ctctgtgggg gtctcgacgg cttcttcgcg     1200

gtcaagcacg cgcgctacac cctaaagcca ctgctgcgcg gaccctgggc ggaggaagaa     1260

aaggggcgcg tgtacgggga tgggtccgca cggatcctgc acgtctacac ccgcgagggc     1320

ttcagcttcg aggccctgcc gccgcgcgcc agctgcgaaa cccccgcgtc cacaccggag     1380

gcccacgagc atgctccggc gcacagcaac ccgagcggac gcgcagcact ggcctcgcag     1440

ctcttggacc agtccgctct ctcgcccgct gggggctcag gaccgcagac gtggtggcgg     1500

cggcggcgcc gctccatctc ccgggcccgc caggtggagc tgcttctggt ggctgacgcg     1560

tccatggcgc ggttgtatgg ccggggcctg cagcattacc tgctgaccct ggcctccatc     1620

gccaataggc tgtacagcca tgctagcatc gagaaccaca tccgcctggc cgtggtgaag     1680

gtggtggtgc taggcgacaa ggacaagagc ctggaagtga gcaagaacgc tgccaccaca     1740

ctcaagaact tttgcaagtg gcagcaccaa cacaaccagc tgggagatga ccatgaggag     1800

cactacgatg cagctatcct gtttactcgg gaggatttat gtgggcatca ttcatgtgac     1860

accctgggaa tggcagacgt tgggaccata tgttctccag agcgcagctg tgctgtgatt     1920

gaagacgatg gcctccacgc agccttcact gtggctcacg aaatcggaca tttacttggc     1980

ctctcccatg acgattccaa attctgtgaa gagacctttg gttccacaga agataagcgc     2040

ttaatgtctt ccatccttac cagcattgat gcatctaagc cctggtccaa atgcacttca     2100

gccaccatca cagaattcct ggatgatggc catggtaact gtttgctgga cctaccacga     2160

aagcagatcc tgggccccga agaactccca ggacagacct acgatgccac ccagcagtgc     2220

aacctgacat tcgggcctga gtactccgtg tgtcccggca tggatgtctg tgctcgcctg     2280

tggtgtgctg tggtacgcca gggccagatg gtctgtctga ccaagaagct gcctgcggtg     2340

gaagggacgc cttgtggaaa ggggagaatc tgcctgcagg gcaaatgtgt ggacaaaacc     2400

aagaaaaaat attattcaac gtcaagccat ggcaactggg gatcttgggg atcctggggc     2460

cagtgttctc gctcatgtgg aggaggagtg cagtttgcct atcgtcactg taataaccct     2520

gctcccagaa acaacggacg ctactgcaca gggaagaggg ccatctaccg ctcctgcagt     2580

ctcatgccct gcccacccaa tggtaaatca tttcgtcatg aacagtgtga ggccaaaaat     2640

ggctatcagt ctgatgcaaa aggagtcaaa acttttgtgg aatgggttcc caaatatgca     2700

ggtgtcctgc cagcggatgt gtgcaagctg acctgcagag ccaagggcac tggctactat     2760

gtggtatttt ctccaaaggt gaccgatggc actgaatgta ggctgtacag taattccgtc     2820

tgcgtccggg ggaagtgtgt gagaactggc tgtgacggca tcattggctc aaagctgcag     2880

tatgacaagt gcggagtatg tggaggagac aactccagct gtacaaagat tgttggaacc     2940

tttaataaga aaagtaaggg ttacactgac gtggtgagga ttcctgaagg ggcaacccac     3000

ataaaagttc gacagttcaa agccaaagac cagactagat tcactgccta tttagccctg     3060

aaaaagaaaa acggtgagta ccttatcaat ggaaagtaca tgatctccac ttcagagact     3120

atcattgaca tcaatggaac agtcatgaac tatagcggtt ggagccacag ggatgacttc     3180

ctgcatggca tgggctactc tgccacgaag gaaattctaa tagtgcagat tcttgcaaca     3240

gaccccacta aaccattaga tgtccgttat agcttttttg ttcccaagaa gtccactcca     3300

aaagtaaact ctgtcactag tcatggcagc aataaagtgg gatcacacac ttcgcagccg     3360

cagtgggtca cgggcccatg gctcgcctgc tctaggacct gtgacacagg ttggcacacc     3420

agaacggtgc agtgccagga tggaaaccgg aagttagcaa aaggatgtcc tctctcccaa     3480

aggccttctg cgtttaagca atgcttgttg aagaaatgtt agcctgtggt tatgatctta     3540

tgcacaaaga taactggagg attcagcact gatgcagtcg tggtgaacag gaggtctacc     3600

taacgcacag aaagtcatgc ttcagtgaca ttgtcaacag gagtccaatt atgggcagaa     3660

tctgctctct gtgaccaaaa gaggatgtgc actgcttcac gtgacagtgg tgaccttgca     3720

atatagaaaa acttgggagt tattgaacat cccctgggct tacaagaaac actgatgaat     3780

gtaaaatcag gggacatttg aagatggcag aactgtctcc cccttgtcac ctacctctga     3840

tagaatgtct ttaatggtat cataatcatt ttcacccata atacacagta gcttcttctt     3900

actgtttgta aatacattct cccttggtat gtcactttat atcccctggt tctattaaaa     3960

tatccatata tatttctata aaaaaagtgt ttgaccaaag taggtctgca gctatttcaa     4020

cttccttccg tttccagaaa gagctgtgga tattttactg gaaattaaga acttgctgct     4080

gttttaataa gatgtagtat attttctgac tacaggagat aaaatttcag tcaaaaaacc     4140

attttgacag caagtatctt ctgagaaatt ttgaaaagta aatagatctc agtgtatcta     4200

gtcacttaaa tacatacacg ggttcattta cttaaacctt tgactgcctg tatttttttc     4260

aggtagctag ccaaattaat gcataatttc agatgtagaa gtagggtttg cgtgtgtgtg     4320

tgtgatcata ctcaagagtc taaaaactag tttccttgtg ttggaaattt aaaaggaaaa     4380

aaatcgtatt tcactgtgtt ttcaatttat attttcacaa ctactttctc tctccagagc     4440

tttcatctga tatctcacaa tgtatgatat acgtacaaaa cacacagcaa gttttctatc     4500

atgtccaaca cattcaacac tggtatacct cctaccagca agcctttaaa atgcatttgt     4560

gtttgcttat ttgttttgtt caagggttca gtaagaccta caatgttttg tatttcttga     4620

cttattttat tagaaacatt aaagatcact tggtagttag ccacattgag aagtggttat     4680

cattgttaat gtggttaatg ccaaaaagtg gttaatatta ataagactgt ttccacacca     4740

taggcaataa tttcttaatt taaaaaatct aagtatattc ctattgtact aaatattttt     4800

cccaactgga aagcacttga ttgtacccgt aagtgtttga gtgatgacat gtgatgattt     4860

tcagaaagtt gttgtttttg tttccatagc ctgtttaagt aggttgtaag tttgaatagt     4920

tagacatgga aattatttta taagcacaca cctaaagata tctttttaga tgataaaatg     4980

tacacccccc catcaccaac ctcacaactt agaaaatcta agttgtttga tttctttggg     5040

atttcttttg ttgtgaaaca ctgcaaagcc aatttttctt tataaaaatt catagtaatc     5100

ctgccaaatg tgcctattgt taaagatttg catgtgaaga tcttagggaa ccactgtttg     5160

agttctacaa gctcatgaga gtttattttt attataagat gtttttaata taaaagaatt     5220

atgtaactga tcactatatt acatcatttc agtgggccag gaaaatagat gtcttgctgt     5280

tttcagtatt ttcttaagaa attgctttta aaacaaataa ttgttttaca aaaccaataa     5340

ttatcctttg aattttcata gactgacttt gcttttgacg tagaaatttt ttttctcaat     5400

aaattatcac tttgagaaat gaggcctgta caaggctgat aacctatatg tgatggagat     5460

cacccaatgc caagggcaga aagcaaacct agttaaatag gtgagaaaaa aaataataat     5520

cccagtgcca tttgtctgtg caaagagaat taggagagag gttaatgtta cttttttcca     5580

ttttggaaat aattttaatc aagtaactca aatgtgacaa aatttatttt tattttttgt     5640

ggttatattc ccaacaacat taaaaaatac tcgaggcata aatgtagttg tctcctactc     5700

tgcttctctt actatactca tacattttta atatggttta tcaatgattc atgtttccct     5760

caaatagtga tggtttacac ctgtcatgga aacaatccta gagagctcag agcaattaaa     5820

ccactattcc atgcttttaa gtagttttct ccaccttttt cttatgagtc tcactagatt     5880

gactgaggaa tgtatgtcta aattcctgga gaagatgata tggattggaa actgaaattc     5940

agagaaatgg agtgttcaat agataccacg aattgtgaac aaagggaaaa ttctatacaa     6000

ctcaatctaa gtcagtccac tttgacttcg tactgtcttt cacctttcca ttgttgcatc     6060

ttgaattttt taaaatgtct agaattcagg atgctagggg ctacttcttt aaaaaaaaaa     6120

aaaaaaaaga attcgtctga aaatgctcag gtttgtaaga atctaatctc acttacataa     6180

ctaagcactc cataataagt tttattaagt acaaagggag ccagaaaaaa tgacatttat     6240

ttcttctaga tcagaaaaat ttaaattaag ccctgccttg ctgtttagaa atatgtgggc     6300

attgttataa tttattcaat aaatttatgt tcctttgcct tcctgtggaa acagttttat     6360

cccactaaac taggaattag gggataaatc acaaacaaaa aaaaagttgc agcactgaaa     6420

aaaagtaatt tattgttttt gcaactggta tgtgaatttg tgtgataaaa ttatttattc     6480

ttatttaaca aaaatatgtt caaatttttc tatatttaaa atgttttgct gttgtcctac     6540

tttttaattt atgcttcatg tttgtgtata aagtacactt ttacactttg tgagtttaca     6600

taatatacag cactggttgc ttttgtattt ttttacagaa agctttctgt gtgaagcagg     6660

tgtatatgta tatattcctc atgtattctt attctgatac tatcattttt ctttccaagg     6720

aaattttaat ctgtcatgac caatagtgtt cattacttgt gcctatgata ataggttttt     6780

tacatcacat taacactatt ttttccaagt cacaaataag aaaaacactt attcaatgaa     6840

acaaggtgca agttttaaat ttgggtacac aaatagccta gaagcttcct acagacgcta     6900

agacacagcc aataatcaga tcctttcact tcatcgagaa acttggacaa gtcgatattg     6960

atgtattaga tgaaagttgt ctacacacaa cttctgaggg atacaaacga taataaaacc     7020

aaatgttgtc tgtttctcct ttagaaacac ctcctaaaat taatatcatt tagtctctag     7080

tgtctgtagg attctacaga tgagcacaaa tagattgggt ttgtataaca aatgctaata     7140

gtcataactg tttctacaaa tatggggtgt ccattaagag aatgtgatgt tttcctactg     7200

ctgttgaatc ccatggggtg attataggac ttgaaatagg cagagtcacc tctgatgaca     7260

tcagcttgcc tctgtgattt cacagtctga tcctggcaac aagacaaagc acccttggac     7320

acacagccaa tctctggttg tgatatttcc ccattgattc cttccttgtt aacaaggtca     7380

ttttaatggt tcaggtgagg acagcagcca gattcaaagt ccagaatttg tgctgttaca     7440

tagagttcac actgtcaaat aacattgaat ttaataatga tcaaattttt ctagtagtct     7500

ttggcagagt gtataatctc attggcatga ttggtgaata ttactaatct ctttataatg     7560

aaagatgctt tacaaatacc ttatatttgc taacatttca aaactactaa ataaatgaaa     7620

tagccatgtg tacagaaatg gtcatttaaa gctttaatag aaccaaattc aagacaatgt     7680

atcatttaga cacacagaaa aggaacttgt atgttttccc tattattttt ctcatttgcc     7740

aacaatctat agttttaggt tatcaaacag atagatcaac ttaactggct agtacattga     7800

aaaatcttcc taagaatcct ttgttagcat aatctataga gataatttct caaattatat     7860

catcatgatg catataaact ctataatgta taattgtgtt tcatttattt aatgtatgag     7920

aacatattga aatacaaaac catgcattag ccaaaaaatt ggaatacagg tagtgttcag     7980

atcagcaaaa cattcagtct ggtaaatgcc tgcctggggc tatgatatca ttctcaatgc     8040

aggttttatg gaaaaactaa aagaatatgt tgttagatga tgttggtttt gaaaaaaaaa     8100

agacattaac atacacatta gttagcccag ttaattgcat tctactaata tagttgcaca     8160

ttagcaataa ttttgctgtc tctggtcttt attttgtggc ttcaactaac tggaccatgt     8220

ggactgtaaa ggtcaaatgg aaaaaacgag cagtggcccc tcatcctgta aggtactgct     8280

acatcagagt gacctaaaag tctaacactg tgaggaaaac tgtgatttgt aggaaaaaaa     8340

aaaaaaacaa ataaaaaaca gggcatgctt tttaattttt ttccactttc ctttggcaca     8400

cccaatgaac aattctaatt tttattgagg tgctaacatc tttcgtgacc gactgtcaaa     8460

tgtggtattt ttgagttact atttttctac atgattttac agtttgcaag aaagacctct     8520

aagctttgtg tcacggtagg gcacaacttg atactcaaaa tttgaaaaat aagcacatcc     8580

aatgattgtt ttgaccaaca gtggtcagtg acgtaaactg catgtgcatc tgaggacatt     8640

taaggggtca ttaaaatttg aggagcatca ggccggagta gcagactttt agatgagtca     8700

tatttcagca ttcactaagt cctcagcatt ccattcaaac tgtcgtgtat atttggcctg     8760

attttttttc aagctttgca ataatttatg ttattggtaa acacttggtg actatatctc     8820

agccttttct ttaacaactc acaatatatt agaaacacgt ctacctatac tgagagtata     8880

tttacaatag aagaacatac tgtatgtgac tttgtaaagc tagacttttg attaagaaat     8940

atataatctc tggatgctat ttttgcatta tacactcagg cacaacgtaa accttgatgg     9000

ctcatcttgc tacaattacg agttgaaaaa cactacttac gtatttgtat gacctattag     9060

tcagaggaaa tcatacatat gctttgtaaa tagactttgc agataactaa atagactgaa     9120

gaaatatgtt gcatttgata gaagcaattg cataaatatt tggtttctat attagagtct     9180

gtgagtaaag tcaagtaata aacctaagta ggtataacag atttttaaac cttgaaactt     9240

gctttgatgg tagagaaaat cattgaagat ttacatactg tatataagat gtaaaatgta     9300

cgctgcttat taccctcaat tttccagaag caatggtata taatgcagtt gaaaaaccaa     9360

aaatcttgga aaactaagac gggtcttgtt taaaatgtct ctcagctttg gcaaccttca     9420

aatcttaatc aactatttaa agcattactg tgtcttgtag cctgcattcc acaacagctc     9480

tgttattcag gtaaaagact tgaactgagc cgtttgggac ctatactgta atattttcat     9540

tgaggaacaa tatcctattt tgtaaagcat ttccctatgt gtgactttaa actgtaaaat     9600

taaacactgc ttttgtgggt tcagtgggca taataaatat aaattgtaaa ctaggttaaa     9660

gta                                                                   9663


<210>  2
<211>  930
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Leu Gly Trp Ala Ser Leu Leu Leu Cys Ala Phe Arg Leu Pro 
1               5                   10                  15      


Leu Ala Ala Val Gly Pro Ala Ala Thr Pro Ala Gln Asp Lys Ala Gly 
            20                  25                  30          


Gln Pro Pro Thr Ala Ala Ala Ala Ala Gln Pro Arg Arg Arg Gln Gly 
        35                  40                  45              


Glu Glu Val Gln Glu Arg Ala Glu Pro Pro Gly His Pro His Pro Leu 
    50                  55                  60                  


Ala Gln Arg Arg Arg Ser Lys Gly Leu Val Gln Asn Ile Asp Gln Leu 
65                  70                  75                  80  


Tyr Ser Gly Gly Gly Lys Val Gly Tyr Leu Val Tyr Ala Gly Gly Arg 
                85                  90                  95      


Arg Phe Leu Leu Asp Leu Glu Arg Asp Gly Ser Val Gly Ile Ala Gly 
            100                 105                 110         


Phe Val Pro Ala Gly Gly Gly Thr Ser Ala Pro Trp Arg His Arg Ser 
        115                 120                 125             


His Cys Phe Tyr Arg Gly Thr Val Asp Gly Ser Pro Arg Ser Leu Ala 
    130                 135                 140                 


Val Phe Asp Leu Cys Gly Gly Leu Asp Gly Phe Phe Ala Val Lys His 
145                 150                 155                 160 


Ala Arg Tyr Thr Leu Lys Pro Leu Leu Arg Gly Pro Trp Ala Glu Glu 
                165                 170                 175     


Glu Lys Gly Arg Val Tyr Gly Asp Gly Ser Ala Arg Ile Leu His Val 
            180                 185                 190         


Tyr Thr Arg Glu Gly Phe Ser Phe Glu Ala Leu Pro Pro Arg Ala Ser 
        195                 200                 205             


Cys Glu Thr Pro Ala Ser Thr Pro Glu Ala His Glu His Ala Pro Ala 
    210                 215                 220                 


His Ser Asn Pro Ser Gly Arg Ala Ala Leu Ala Ser Gln Leu Leu Asp 
225                 230                 235                 240 


Gln Ser Ala Leu Ser Pro Ala Gly Gly Ser Gly Pro Gln Thr Trp Trp 
                245                 250                 255     


Arg Arg Arg Arg Arg Ser Ile Ser Arg Ala Arg Gln Val Glu Leu Leu 
            260                 265                 270         


Leu Val Ala Asp Ala Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gln 
        275                 280                 285             


His Tyr Leu Leu Thr Leu Ala Ser Ile Ala Asn Arg Leu Tyr Ser His 
    290                 295                 300                 


Ala Ser Ile Glu Asn His Ile Arg Leu Ala Val Val Lys Val Val Val 
305                 310                 315                 320 


Leu Gly Asp Lys Asp Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr 
                325                 330                 335     


Thr Leu Lys Asn Phe Cys Lys Trp Gln His Gln His Asn Gln Leu Gly 
            340                 345                 350         


Asp Asp His Glu Glu His Tyr Asp Ala Ala Ile Leu Phe Thr Arg Glu 
        355                 360                 365             


Asp Leu Cys Gly His His Ser Cys Asp Thr Leu Gly Met Ala Asp Val 
    370                 375                 380                 


Gly Thr Ile Cys Ser Pro Glu Arg Ser Cys Ala Val Ile Glu Asp Asp 
385                 390                 395                 400 


Gly Leu His Ala Ala Phe Thr Val Ala His Glu Ile Gly His Leu Leu 
                405                 410                 415     


Gly Leu Ser His Asp Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser 
            420                 425                 430         


Thr Glu Asp Lys Arg Leu Met Ser Ser Ile Leu Thr Ser Ile Asp Ala 
        435                 440                 445             


Ser Lys Pro Trp Ser Lys Cys Thr Ser Ala Thr Ile Thr Glu Phe Leu 
    450                 455                 460                 


Asp Asp Gly His Gly Asn Cys Leu Leu Asp Leu Pro Arg Lys Gln Ile 
465                 470                 475                 480 


Leu Gly Pro Glu Glu Leu Pro Gly Gln Thr Tyr Asp Ala Thr Gln Gln 
                485                 490                 495     


Cys Asn Leu Thr Phe Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp 
            500                 505                 510         


Val Cys Ala Arg Leu Trp Cys Ala Val Val Arg Gln Gly Gln Met Val 
        515                 520                 525             


Cys Leu Thr Lys Lys Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys 
    530                 535                 540                 


Gly Arg Ile Cys Leu Gln Gly Lys Cys Val Asp Lys Thr Lys Lys Lys 
545                 550                 555                 560 


Tyr Tyr Ser Thr Ser Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp 
                565                 570                 575     


Gly Gln Cys Ser Arg Ser Cys Gly Gly Gly Val Gln Phe Ala Tyr Arg 
            580                 585                 590         


His Cys Asn Asn Pro Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly 
        595                 600                 605             


Lys Arg Ala Ile Tyr Arg Ser Cys Ser Leu Met Pro Cys Pro Pro Asn 
    610                 615                 620                 


Gly Lys Ser Phe Arg His Glu Gln Cys Glu Ala Lys Asn Gly Tyr Gln 
625                 630                 635                 640 


Ser Asp Ala Lys Gly Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr 
                645                 650                 655     


Ala Gly Val Leu Pro Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys 
            660                 665                 670         


Gly Thr Gly Tyr Tyr Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr 
        675                 680                 685             


Glu Cys Arg Leu Tyr Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val 
    690                 695                 700                 


Arg Thr Gly Cys Asp Gly Ile Ile Gly Ser Lys Leu Gln Tyr Asp Lys 
705                 710                 715                 720 


Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Thr Lys Ile Val Gly 
                725                 730                 735     


Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro 
            740                 745                 750         


Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln 
        755                 760                 765             


Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr 
    770                 775                 780                 


Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp 
785                 790                 795                 800 


Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp 
                805                 810                 815     


Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val 
            820                 825                 830         


Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser 
        835                 840                 845             


Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser 
    850                 855                 860                 


His Gly Ser Asn Lys Val Gly Ser His Thr Ser Gln Pro Gln Trp Val 
865                 870                 875                 880 


Thr Gly Pro Trp Leu Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His 
                885                 890                 895     


Thr Arg Thr Val Gln Cys Gln Asp Gly Asn Arg Lys Leu Ala Lys Gly 
            900                 905                 910         


Cys Pro Leu Ser Gln Arg Pro Ser Ala Phe Lys Gln Cys Leu Leu Lys 
        915                 920                 925             


Lys Cys 
    930 


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  3
gcucaaagcu gcaguauga                                                    19


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  4
gaaguccacu ccaaaagua                                                    19


<210>  5
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  5
gcacuacgau gcagcuauc                                                    19


<210>  6
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  6
cgaaggaaau ucuaauagu                                                    19


<210>  7
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  7
ccggtctaac atttcttcaa caagcagacc gg                                     32


<210>  8
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  8
ccggtcttat acacaaacat gaagcagacc gg                                     32


<210>  9
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  9
ccggtctaca tcttattaaa acagcagacc gg                                     32


<210>  10
<211>  4410
<212>  DNA
<213>  Homo sapiens

<400>  10
ggggagaacc cacagggaga cccacagaca catatgcacg agagagacag aggaggaaag       60

agacagagac aaaggcacag cggaagaagg cagagacagg gcaggcacag aagcggccca      120

gacagagtcc tacagaggga gaggccagag aagctgcaga agacacaggc agggagagac      180

aaagatccag gaaaggaggg ctcaggagga gagtttggag aagccagacc cctgggcacc      240

tctcccaagc ccaaggacta agttttctcc atttccttta acggtcctca gcccttctga      300

aaactttgcc tctgaccttg gcaggagtcc aagcccccag gctacagaga ggagctttcc      360

aaagctaggg tgtggaggac ttggtgccct agacggcctc agtccctccc agctgcagta      420

ccagtgccat gtcccagaca ggctcgcatc ccgggagggg cttggcaggg cgctggctgt      480

ggggagccca accctgcctc ctgctcccca ttgtgccgct ctcctggctg gtgtggctgc      540

ttctgctact gctggcctct ctcctgccct cagcccggct ggccagcccc ctcccccggg      600

aggaggagat cgtgtttcca gagaagctca acggcagcgt cctgcctggc tcgggcgccc      660

ctgccaggct gttgtgccgc ttgcaggcct ttggggagac gctgctacta gagctggagc      720

aggactccgg tgtgcaggtc gaggggctga cagtgcagta cctgggccag gcgcctgagc      780

tgctgggtgg agcagagcct ggcacctacc tgactggcac catcaatgga gatccggagt      840

cggtggcatc tctgcactgg gatgggggag ccctgttagg cgtgttacaa tatcgggggg      900

ctgaactcca cctccagccc ctggagggag gcacccctaa ctctgctggg ggacctgggg      960

ctcacatcct acgccggaag agtcctgcca gcggtcaagg tcccatgtgc aacgtcaagg     1020

ctcctcttgg aagccccagc cccagacccc gaagagccaa gcgctttgct tcactgagta     1080

gatttgtgga gacactggtg gtggcagatg acaagatggc cgcattccac ggtgcggggc     1140

taaagcgcta cctgctaaca gtgatggcag cagcagccaa ggccttcaag cacccaagca     1200

tccgcaatcc tgtcagcttg gtggtgactc ggctagtgat cctggggtca ggcgaggagg     1260

ggccccaagt ggggcccagt gctgcccaga ccctgcgcag cttctgtgcc tggcagcggg     1320

gcctcaacac ccctgaggac tcggaccctg accactttga cacagccatt ctgtttaccc     1380

gtcaggacct gtgtggagtc tccacttgcg acacgctggg tatggctgat gtgggcaccg     1440

tctgtgaccc ggctcggagc tgtgccattg tggaggatga tgggctccag tcagccttca     1500

ctgctgctca tgaactgggt catgtcttca acatgctcca tgacaactcc aagccatgca     1560

tcagtttgaa tgggcctttg agcacctctc gccatgtcat ggcccctgtg atggctcatg     1620

tggatcctga ggagccctgg tccccctgca gtgcccgctt catcactgac ttcctggaca     1680

atggctatgg gcactgtctc ttagacaaac cagaggctcc attgcatctg cctgtgactt     1740

tccctggcaa ggactatgat gctgaccgcc agtgccagct gaccttcggg cccgactcac     1800

gccattgtcc acagctgccg ccgccctgtg ctgccctctg gtgctctggc cacctcaatg     1860

gccatgccat gtgccagacc aaacactcgc cctgggccga tggcacaccc tgcgggcccg     1920

cacaggcctg catgggtggt cgctgcctcc acatggacca gctccaggac ttcaatattc     1980

cacaggctgg tggctggggt ccttggggac catggggtga ctgctctcgg acctgtgggg     2040

gtggtgtcca gttctcctcc cgagactgca cgaggcctgt cccccggaat ggtggcaagt     2100

actgtgaggg ccgccgtacc cgcttccgct cctgcaacac tgaggactgc ccaactggct     2160

cagccctgac cttccgcgag gagcagtgtg ctgcctacaa ccaccgcacc gacctcttca     2220

agagcttccc agggcccatg gactgggttc ctcgctacac aggcgtggcc ccccaggacc     2280

agtgcaaact cacctgccag gcccaggcac tgggctacta ctatgtgctg gagccacggg     2340

tggtagatgg gaccccctgt tccccggaca gctcctcggt ctgtgtccag ggccgatgca     2400

tccatgctgg ctgtgatcgc atcattggct ccaagaagaa gtttgacaag tgcatggtgt     2460

gcggagggga cggttctggt tgcagcaagc agtcaggctc cttcaggaaa ttcaggtacg     2520

gatacaacaa tgtggtcact atccccgcgg gggccaccca cattcttgtc cggcagcagg     2580

gaaaccctgg ccaccggagc atctacttgg ccctgaagct gccagatggc tcctatgccc     2640

tcaatggtga atacacgctg atgccctccc ccacagatgt ggtactgcct ggggcagtca     2700

gcttgcgcta cagcggggcc actgcagcct cagagacact gtcaggccat gggccactgg     2760

cccagccttt gacactgcaa gtcctagtgg ctggcaaccc ccaggacaca cgcctccgat     2820

acagcttctt cgtgccccgg ccgacccctt caacgccacg ccccactccc caggactggc     2880

tgcaccgaag agcacagatt ctggagatcc ttcggcggcg cccctgggcg ggcaggaaat     2940

aacctcacta tcccggctgc cctttctggg caccggggcc tcggacttag ctgggagaaa     3000

gagagagctt ctgttgctgc ctcatgctaa gactcagtgg ggaggggctg tgggcgtgag     3060

acctgcccct cctctctgcc ctaatgcgca ggctggccct gccctggttt cctgccctgg     3120

gaggcagtga tgggttagtg gatggaaggg gctgacagac agccctccat ctaaactgcc     3180

ccctctgccc tgcgggtcac aggagggagg gggaaggcag ggagggcctg ggccccagtt     3240

gtatttattt agtatttatt cacttttatt tagcaccagg gaaggggaca aggactaggg     3300

tcctggggaa cctgacccct gacccctcat agccctcacc ctggggctag gaaatccagg     3360

gtggtggtga taggtataag tggtgtgtgt atgcgtgtgt gtgtgtgtga aaatgtgtgt     3420

gtgcttatgt atgaggtaca acctgttctg ctttcctctt cctgaatttt attttttggg     3480

aaaagaaaag tcaagggtag ggtgggcctt cagggagtga gggattatct tttttttttt     3540

ttctttcttt ctttcttttt tttttttgag acagaatctc gctctgtcgc ccaggctgga     3600

gtgcaatggc acaatctcgg ctcactgcat cctccgcctc ccgggttcaa gtgattctca     3660

tgcctcagcc tcctgagtag ctgggattac aggctcctgc caccacgccc ggctaatttt     3720

tgttttgttt tgtttggaga cagagtctcg ctattgtcac cagggctgga atgatttcag     3780

ctcactgcaa ccttcgccac ctgggttcca gcaattctcc tgcctcagcc tcccgagtag     3840

ctgagattat aggcacctac caccacgccc ggctaatttt tgtattttta gtagagacgg     3900

ggtttcacca tgttggccag gctggtctcg aactcctgac cttaggtgat ccactcgcct     3960

tcatctccca aagtgctggg attacaggcg tgagccaccg tgcctggcca cgcccaacta     4020

atttttgtat ttttagtaga gacagggttt caccatgttg gccaggctgc tcttgaactc     4080

ctgacctcag gtaatcgacc tgcctcggcc tcccaaagtg ctgggattac aggtgtgagc     4140

caccacgccc ggtacatatt ttttaaattg aattctacta tttatgtgat ccttttggag     4200

tcagacagat gtggttgcat cctaactcca tgtctctgag cattagattt ctcatttgcc     4260

aataataata cctcccttag aagtttgttg tgaggattaa ataatgtaaa taaagaacta     4320

gcataacact caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      4410


<210>  11
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Gln Thr Gly Ser His Pro Gly Arg Gly Leu Ala Gly Arg Trp 
1               5                   10                  15      


Leu Trp Gly Ala Gln Pro Cys Leu Leu Leu Pro Ile Val Pro Leu Ser 
            20                  25                  30          


Trp Leu Val Trp Leu Leu Leu Leu Leu Leu Ala Ser Leu Leu Pro Ser 
        35                  40                  45              


Ala Arg Leu Ala Ser Pro Leu Pro Arg Glu Glu Glu Ile Val Phe Pro 
    50                  55                  60                  


Glu Lys Leu Asn Gly Ser Val Leu Pro Gly Ser Gly Ala Pro Ala Arg 
65                  70                  75                  80  


Leu Leu Cys Arg Leu Gln Ala Phe Gly Glu Thr Leu Leu Leu Glu Leu 
                85                  90                  95      


Glu Gln Asp Ser Gly Val Gln Val Glu Gly Leu Thr Val Gln Tyr Leu 
            100                 105                 110         


Gly Gln Ala Pro Glu Leu Leu Gly Gly Ala Glu Pro Gly Thr Tyr Leu 
        115                 120                 125             


Thr Gly Thr Ile Asn Gly Asp Pro Glu Ser Val Ala Ser Leu His Trp 
    130                 135                 140                 


Asp Gly Gly Ala Leu Leu Gly Val Leu Gln Tyr Arg Gly Ala Glu Leu 
145                 150                 155                 160 


His Leu Gln Pro Leu Glu Gly Gly Thr Pro Asn Ser Ala Gly Gly Pro 
                165                 170                 175     


Gly Ala His Ile Leu Arg Arg Lys Ser Pro Ala Ser Gly Gln Gly Pro 
            180                 185                 190         


Met Cys Asn Val Lys Ala Pro Leu Gly Ser Pro Ser Pro Arg Pro Arg 
        195                 200                 205             


Arg Ala Lys Arg Phe Ala Ser Leu Ser Arg Phe Val Glu Thr Leu Val 
    210                 215                 220                 


Val Ala Asp Asp Lys Met Ala Ala Phe His Gly Ala Gly Leu Lys Arg 
225                 230                 235                 240 


Tyr Leu Leu Thr Val Met Ala Ala Ala Ala Lys Ala Phe Lys His Pro 
                245                 250                 255     


Ser Ile Arg Asn Pro Val Ser Leu Val Val Thr Arg Leu Val Ile Leu 
            260                 265                 270         


Gly Ser Gly Glu Glu Gly Pro Gln Val Gly Pro Ser Ala Ala Gln Thr 
        275                 280                 285             


Leu Arg Ser Phe Cys Ala Trp Gln Arg Gly Leu Asn Thr Pro Glu Asp 
    290                 295                 300                 


Ser Asp Pro Asp His Phe Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp 
305                 310                 315                 320 


Leu Cys Gly Val Ser Thr Cys Asp Thr Leu Gly Met Ala Asp Val Gly 
                325                 330                 335     


Thr Val Cys Asp Pro Ala Arg Ser Cys Ala Ile Val Glu Asp Asp Gly 
            340                 345                 350         


Leu Gln Ser Ala Phe Thr Ala Ala His Glu Leu Gly His Val Phe Asn 
        355                 360                 365             


Met Leu His Asp Asn Ser Lys Pro Cys Ile Ser Leu Asn Gly Pro Leu 
    370                 375                 380                 


Ser Thr Ser Arg His Val Met Ala Pro Val Met Ala His Val Asp Pro 
385                 390                 395                 400 


Glu Glu Pro Trp Ser Pro Cys Ser Ala Arg Phe Ile Thr Asp Phe Leu 
                405                 410                 415     


Asp Asn Gly Tyr Gly His Cys Leu Leu Asp Lys Pro Glu Ala Pro Leu 
            420                 425                 430         


His Leu Pro Val Thr Phe Pro Gly Lys Asp Tyr Asp Ala Asp Arg Gln 
        435                 440                 445             


Cys Gln Leu Thr Phe Gly Pro Asp Ser Arg His Cys Pro Gln Leu Pro 
    450                 455                 460                 


Pro Pro Cys Ala Ala Leu Trp Cys Ser Gly His Leu Asn Gly His Ala 
465                 470                 475                 480 


Met Cys Gln Thr Lys His Ser Pro Trp Ala Asp Gly Thr Pro Cys Gly 
                485                 490                 495     


Pro Ala Gln Ala Cys Met Gly Gly Arg Cys Leu His Met Asp Gln Leu 
            500                 505                 510         


Gln Asp Phe Asn Ile Pro Gln Ala Gly Gly Trp Gly Pro Trp Gly Pro 
        515                 520                 525             


Trp Gly Asp Cys Ser Arg Thr Cys Gly Gly Gly Val Gln Phe Ser Ser 
    530                 535                 540                 


Arg Asp Cys Thr Arg Pro Val Pro Arg Asn Gly Gly Lys Tyr Cys Glu 
545                 550                 555                 560 


Gly Arg Arg Thr Arg Phe Arg Ser Cys Asn Thr Glu Asp Cys Pro Thr 
                565                 570                 575     


Gly Ser Ala Leu Thr Phe Arg Glu Glu Gln Cys Ala Ala Tyr Asn His 
            580                 585                 590         


Arg Thr Asp Leu Phe Lys Ser Phe Pro Gly Pro Met Asp Trp Val Pro 
        595                 600                 605             


Arg Tyr Thr Gly Val Ala Pro Gln Asp Gln Cys Lys Leu Thr Cys Gln 
    610                 615                 620                 


Ala Gln Ala Leu Gly Tyr Tyr Tyr Val Leu Glu Pro Arg Val Val Asp 
625                 630                 635                 640 


Gly Thr Pro Cys Ser Pro Asp Ser Ser Ser Val Cys Val Gln Gly Arg 
                645                 650                 655     


Cys Ile His Ala Gly Cys Asp Arg Ile Ile Gly Ser Lys Lys Lys Phe 
            660                 665                 670         


Asp Lys Cys Met Val Cys Gly Gly Asp Gly Ser Gly Cys Ser Lys Gln 
        675                 680                 685             


Ser Gly Ser Phe Arg Lys Phe Arg Tyr Gly Tyr Asn Asn Val Val Thr 
    690                 695                 700                 


Ile Pro Ala Gly Ala Thr His Ile Leu Val Arg Gln Gln Gly Asn Pro 
705                 710                 715                 720 


Gly His Arg Ser Ile Tyr Leu Ala Leu Lys Leu Pro Asp Gly Ser Tyr 
                725                 730                 735     


Ala Leu Asn Gly Glu Tyr Thr Leu Met Pro Ser Pro Thr Asp Val Val 
            740                 745                 750         


Leu Pro Gly Ala Val Ser Leu Arg Tyr Ser Gly Ala Thr Ala Ala Ser 
        755                 760                 765             


Glu Thr Leu Ser Gly His Gly Pro Leu Ala Gln Pro Leu Thr Leu Gln 
    770                 775                 780                 


Val Leu Val Ala Gly Asn Pro Gln Asp Thr Arg Leu Arg Tyr Ser Phe 
785                 790                 795                 800 


Phe Val Pro Arg Pro Thr Pro Ser Thr Pro Arg Pro Thr Pro Gln Asp 
                805                 810                 815     


Trp Leu His Arg Arg Ala Gln Ile Leu Glu Ile Leu Arg Arg Arg Pro 
            820                 825                 830         


Trp Ala Gly Arg Lys 
        835         


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcically synthesized

<400>  12
ccgcaauccu gucagcuug                                                    19


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  13
gcgcuuugcu ucacugagu                                                    19


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  14
ggacacacgc cuccgauac                                                    19


<210>  15
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  15
gcaccgaaga gcacagauu                                                    19


<210>  16
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  16
ccggtctttt cacacacaca cacacggacc gg                                     32


<210>  17
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  17
ccggtctaaa aatacaaaaa ttagccgacc gg                                     32


<210>  18
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  18
ccggtcttgt ctctgtctct ttcctcgacc gg                                     32


<210>  19
<211>  2735
<212>  DNA
<213>  Homo sapiens

<400>  19
acaacagtcc ccaggcatca ccattcaaga tgcatccagg ggtcctggct gccttcctct       60

tcttgagctg gactcattgt cgggccctgc cccttcccag tggtggtgat gaagatgatt      120

tgtctgagga agacctccag tttgcagagc gctacctgag atcatactac catcctacaa      180

atctcgcggg aatcctgaag gagaatgcag caagctccat gactgagagg ctccgagaaa      240

tgcagtcttt cttcggctta gaggtgactg gcaaacttga cgataacacc ttagatgtca      300

tgaaaaagcc aagatgcggg gttcctgatg tgggtgaata caatgttttc cctcgaactc      360

ttaaatggtc caaaatgaat ttaacctaca gaattgtgaa ttacacccct gatatgactc      420

attctgaagt cgaaaaggca ttcaaaaaag ccttcaaagt ttggtccgat gtaactcctc      480

tgaattttac cagacttcac gatggcattg ctgacatcat gatctctttt ggaattaagg      540

agcatggcga cttctaccca tttgatgggc cctctggcct gctggctcat gcttttcctc      600

ctgggccaaa ttatggagga gatgcccatt ttgatgatga tgaaacctgg acaagtagtt      660

ccaaaggcta caacttgttt cttgttgctg cgcatgagtt cggccactcc ttaggtcttg      720

accactccaa ggaccctgga gcactcatgt ttcctatcta cacctacacc ggcaaaagcc      780

actttatgct tcctgatgac gatgtacaag ggatccagtc tctctatggt ccaggagatg      840

aagaccccaa ccctaaacat ccaaaaacgc cagacaaatg tgacccttcc ttatcccttg      900

atgccattac cagtctccga ggagaaacaa tgatctttaa agacagattc ttctggcgcc      960

tgcatcctca gcaggttgat gcggagctgt ttttaacgaa atcattttgg ccagaacttc     1020

ccaaccgtat tgatgctgca tatgagcacc cttctcatga cctcatcttc atcttcagag     1080

gtagaaaatt ttgggctctt aatggttatg acattctgga aggttatccc aaaaaaatat     1140

ctgaactggg tcttccaaaa gaagttaaga agataagtgc agctgttcac tttgaggata     1200

caggcaagac tctcctgttc tcaggaaacc aggtctggag atatgatgat actaaccata     1260

ttatggataa agactatccg agactaatag aagaagactt cccaggaatt ggtgataaag     1320

tagatgctgt ctatgagaaa aatggttata tctatttttt caacggaccc atacagtttg     1380

aatacagcat ctggagtaac cgtattgttc gcgtcatgcc agcaaattcc attttgtggt     1440

gttaagtgtc tttttaaaaa ttgttattta aatcctgaag agcatttggg gtaatacttc     1500

cagaagtgcg gggtagggga agaagagcta tcaggagaaa gcttggttct gtgaacaagc     1560

ttcagtaagt tatctttgaa tatgtagtat ctatatgact atgcgtggct ggaaccacat     1620

tgaagaatgt tagagtaatg aaatggagga tctctaaaga gcatctgatt cttgttgctg     1680

tacaaaagca atggttgatg atacttccca caccacaaat gggacacatg gtctgtcaat     1740

gagagcataa tttaaaaata tatttataag gaaattttac aagggcataa agtaaataca     1800

tgcatataat gaataaatca ttcttactaa aaagtataaa atagtatgaa aatggaaatt     1860

tgggagagcc atacataaaa gaaataaacc aaaggaaaat gtctgtaata atagactgta     1920

acttccaaat aaataatttt cattttgcac tgaggatatt cagatgtatg tgcccttctt     1980

cacacagaca ctaacgaaat atcaaagtca ttaaagacag gagacaaaag agcagtggta     2040

agaatagtag atgtggcctt tgaattctgt ttaattttca cttttggcaa tgactcaaag     2100

tctgctctca tataagacaa atattccttt gcatattata aaggataaag aaggatgatg     2160

tctttttatt aaaatatttc aggttcttca gaagtcacac attacaaagt taaaattgtt     2220

atcaaaatag tctaaggcca tggcatccct ttttcataaa ttatttgatt atttaagact     2280

aaaagttgca ttttaaccct attttaccta gctaattatt taattgtcca gtttgtcttg     2340

gatatatagg ctattttcta aagacttgta tagcatgaaa taaaatatat cttataaagt     2400

ggaagtatgt atattaaaaa agagacatcc aaattttttt ttaaagcagt ctactagatt     2460

gtgatccctt gagatatgga aggatgcctt tttttctctg catttaaaaa aatcccccag     2520

cacttcccac agtgcctatt gatacttggg gagggtgctt ggcacttatt gaatatatga     2580

tcggccatca agggaagaac tattgtgctc agagacactg ttgataaaaa ctcaggcaaa     2640

gaaaatgaaa tgcatatttg caaagtgtat taggaagtgt ttatgttgtt tataataaaa     2700

atatattttc aacagacaaa aaaaaaaaaa aaaaa                                2735


<210>  20
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  20

Met His Pro Gly Val Leu Ala Ala Phe Leu Phe Leu Ser Trp Thr His 
1               5                   10                  15      


Cys Arg Ala Leu Pro Leu Pro Ser Gly Gly Asp Glu Asp Asp Leu Ser 
            20                  25                  30          


Glu Glu Asp Leu Gln Phe Ala Glu Arg Tyr Leu Arg Ser Tyr Tyr His 
        35                  40                  45              


Pro Thr Asn Leu Ala Gly Ile Leu Lys Glu Asn Ala Ala Ser Ser Met 
    50                  55                  60                  


Thr Glu Arg Leu Arg Glu Met Gln Ser Phe Phe Gly Leu Glu Val Thr 
65                  70                  75                  80  


Gly Lys Leu Asp Asp Asn Thr Leu Asp Val Met Lys Lys Pro Arg Cys 
                85                  90                  95      


Gly Val Pro Asp Val Gly Glu Tyr Asn Val Phe Pro Arg Thr Leu Lys 
            100                 105                 110         


Trp Ser Lys Met Asn Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp 
        115                 120                 125             


Met Thr His Ser Glu Val Glu Lys Ala Phe Lys Lys Ala Phe Lys Val 
    130                 135                 140                 


Trp Ser Asp Val Thr Pro Leu Asn Phe Thr Arg Leu His Asp Gly Ile 
145                 150                 155                 160 


Ala Asp Ile Met Ile Ser Phe Gly Ile Lys Glu His Gly Asp Phe Tyr 
                165                 170                 175     


Pro Phe Asp Gly Pro Ser Gly Leu Leu Ala His Ala Phe Pro Pro Gly 
            180                 185                 190         


Pro Asn Tyr Gly Gly Asp Ala His Phe Asp Asp Asp Glu Thr Trp Thr 
        195                 200                 205             


Ser Ser Ser Lys Gly Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe 
    210                 215                 220                 


Gly His Ser Leu Gly Leu Asp His Ser Lys Asp Pro Gly Ala Leu Met 
225                 230                 235                 240 


Phe Pro Ile Tyr Thr Tyr Thr Gly Lys Ser His Phe Met Leu Pro Asp 
                245                 250                 255     


Asp Asp Val Gln Gly Ile Gln Ser Leu Tyr Gly Pro Gly Asp Glu Asp 
            260                 265                 270         


Pro Asn Pro Lys His Pro Lys Thr Pro Asp Lys Cys Asp Pro Ser Leu 
        275                 280                 285             


Ser Leu Asp Ala Ile Thr Ser Leu Arg Gly Glu Thr Met Ile Phe Lys 
    290                 295                 300                 


Asp Arg Phe Phe Trp Arg Leu His Pro Gln Gln Val Asp Ala Glu Leu 
305                 310                 315                 320 


Phe Leu Thr Lys Ser Phe Trp Pro Glu Leu Pro Asn Arg Ile Asp Ala 
                325                 330                 335     


Ala Tyr Glu His Pro Ser His Asp Leu Ile Phe Ile Phe Arg Gly Arg 
            340                 345                 350         


Lys Phe Trp Ala Leu Asn Gly Tyr Asp Ile Leu Glu Gly Tyr Pro Lys 
        355                 360                 365             


Lys Ile Ser Glu Leu Gly Leu Pro Lys Glu Val Lys Lys Ile Ser Ala 
    370                 375                 380                 


Ala Val His Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe Ser Gly Asn 
385                 390                 395                 400 


Gln Val Trp Arg Tyr Asp Asp Thr Asn His Ile Met Asp Lys Asp Tyr 
                405                 410                 415     


Pro Arg Leu Ile Glu Glu Asp Phe Pro Gly Ile Gly Asp Lys Val Asp 
            420                 425                 430         


Ala Val Tyr Glu Lys Asn Gly Tyr Ile Tyr Phe Phe Asn Gly Pro Ile 
        435                 440                 445             


Gln Phe Glu Tyr Ser Ile Trp Ser Asn Arg Ile Val Arg Val Met Pro 
    450                 455                 460                 


Ala Asn Ser Ile Leu Trp Cys 
465                 470     


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  21
uuucacacac acacacacgc                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  22
uuuucacaca cacacacacg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  23
uaaaaauaca aaaauuagcc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  24
uuugucucug ucucuuuccu                                                   20


<210>  25
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  25
ccggtctaca cacaccactt atacctgacc gg                                     32


<210>  26
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  26
ccggtctata atctcagcta ctcggggacc gg                                     32


<210>  27
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  27
ccggtcaaac aaaacaaaaa ttagccgacc gg                                     32


<210>  28
<211>  1903
<212>  DNA
<213>  Homo sapiens

<400>  28
agcatgagtc agacagcctc tggctttctg gaagggcaag gactctatat atacagaggg       60

agcttcctag ctgggatatt ggagcagcaa gaggctggga agccatcact taccttgcac      120

tgagaaagaa gacaaaggca agttgaaaag cggagaaata gtggcccagt ggttgaaaaa      180

ttgaagcaaa tgcaggaatt ctttgggctg aaagtgactg ggaaaccaga tgctgaaacc      240

ctgaaggtga tgaagcagcc cagatgtgga gtgcctgatg tggctcagtt tgtcctcact      300

gaggggaacc ctcgctggga gcaaacacat ctgacctaca ggattgaaaa ttacacgcca      360

gatttgccaa gagcagatgt ggaccatgcc attgagaaag ccttccaact ctggagtaat      420

gtcacacctc tgacattcac caaggtctct gagggtcaag cagacatcat gatatctttt      480

gtcaggggag atcatcggga caactctcct tttgatggac ctggaggaaa tcttgctcat      540

gcttttcaac caggcccagg tattggaggg gatgctcatt ttgatgaaga tgaaaggtgg      600

accaacaatt tcagagagta caacttacat cgtgttgcag ctcatgaact cggccattct      660

cttggactct cccattctac tgatatcggg gctttgatgt accctagcta caccttcagt      720

ggtgatgttc agctagctca ggatgacatt gatggcatcc aagccatata tggacgttcc      780

caaaatcctg tccagcccat cggcccacaa accccaaaag cgtgtgacag taagctaacc      840

tttgatgcta taactacgat tcggggagaa gtgatgttct ttaaagacag attctacatg      900

cgcacaaatc ccttctaccc ggaagttgag ctcaatttca tttctgtttt ctggccacaa      960

ctgccaaatg ggcttgaagc tgcttacgaa tttgccgaca gagatgaagt ccggtttttc     1020

aaagggaata agtactgggc tgttcaggga cagaatgtgc tacacggata ccccaaggac     1080

atctacagct cctttggctt ccctagaact gtgaagcata tcgatgctgc tctttctgag     1140

gaaaacactg gaaaaaccta cttctttgtt gctaacaaat actggaggta tgatgaatat     1200

aaacgatcta tggatccagg ttatcccaaa atgatagcac atgactttcc tggaattggc     1260

cacaaagttg atgcagtttt catgaaagat ggatttttct atttctttca tggaacaaga     1320

caatacaaat ttgatcctaa aacgaagaga attttgactc tccagaaagc taatagctgg     1380

ttcaactgca ggaaaaattg aacattacta atttgaatgg aaaacacatg gtgtgagtcc     1440

aaagaaggtg ttttcctgaa gaactgtcta ttttctcagt catttttaac ctctagagtc     1500

actgatacac agaatataat cttatttata cctcagtttg catatttttt tactatttag     1560

aatgtagccc tttttgtact gatataattt agttccacaa atggtgggta caaaaagtca     1620

agtttgtggc ttatggattc atataggcca gagttgcaaa gatcttttcc agagtatgca     1680

actctgacgt tgatcccaga gagcagcttc agtgacaaac atatcctttc aagacagaaa     1740

gagacaggag acatgagtct ttgccggagg aaaagcagct caagaacaca tgtgcagtca     1800

ctggtgtcac cctggatagg caagggataa ctcttctaac acaaaataag tgttttatgt     1860

ttggaataaa gtcaaccttg tttctactgt tttatacact ttc                       1903


<210>  29
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu 
1               5                   10                  15      


Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala 
            20                  25                  30          


Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu 
        35                  40                  45              


Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val 
    50                  55                  60                  


Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro 
65                  70                  75                  80  


Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser 
                85                  90                  95      


Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly 
            100                 105                 110         


Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp 
        115                 120                 125             


Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr 
    130                 135                 140                 


Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu 
145                 150                 155                 160 


Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe 
                165                 170                 175     


Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala 
            180                 185                 190         


Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr 
        195                 200                 205             


Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile 
    210                 215                 220                 


Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn 
225                 230                 235                 240 


Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro 
                245                 250                 255     


Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp 
            260                 265                 270         


Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln 
        275                 280                 285             


Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe 
    290                 295                 300                 


Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr 
305                 310                 315                 320 


Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu 
                325                 330                 335     


Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp 
            340                 345                 350         


Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly 
        355                 360                 365             


Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys 
    370                 375                 380                 


Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys 
385                 390                 395                 400 


Arg Lys Asn 
            


<210>  30
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  30
uuagcuuacu gucacacgc                                                    19


<210>  31
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcialy synthesized

<400>  31
uuauauucau cauaccucc                                                    19


<210>  32
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  32
uugucuucuu ucucagugc                                                    19


<210>  33
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  33
uucguaagca gcuucaagc                                                    19


<210>  34
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  34
ccggtcttcg taagcagctt caagcgaccg g                                      31


<210>  35
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  35
ccggtctaaa gaacatcact ttccgaccgg                                        30


<210>  36
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  36
ccggtctaaa acagtagaaa caagggaccg g                                      31


<210>  37
<211>  2387
<212>  DNA
<213>  Homo sapiens

<400>  37
agacacctct gccctcacca tgagcctctg gcagcccctg gtcctggtgc tcctggtgct       60

gggctgctgc tttgctgccc ccagacagcg ccagtccacc cttgtgctct tccctggaga      120

cctgagaacc aatctcaccg acaggcagct ggcagaggaa tacctgtacc gctatggtta      180

cactcgggtg gcagagatgc gtggagagtc gaaatctctg gggcctgcgc tgctgcttct      240

ccagaagcaa ctgtccctgc ccgagaccgg tgagctggat agcgccacgc tgaaggccat      300

gcgaacccca cggtgcgggg tcccagacct gggcagattc caaacctttg agggcgacct      360

caagtggcac caccacaaca tcacctattg gatccaaaac tactcggaag acttgccgcg      420

ggcggtgatt gacgacgcct ttgcccgcgc cttcgcactg tggagcgcgg tgacgccgct      480

caccttcact cgcgtgtaca gccgggacgc agacatcgtc atccagtttg gtgtcgcgga      540

gcacggagac gggtatccct tcgacgggaa ggacgggctc ctggcacacg cctttcctcc      600

tggccccggc attcagggag acgcccattt cgacgatgac gagttgtggt ccctgggcaa      660

gggcgtcgtg gttccaactc ggtttggaaa cgcagatggc gcggcctgcc acttcccctt      720

catcttcgag ggccgctcct actctgcctg caccaccgac ggtcgctccg acggcttgcc      780

ctggtgcagt accacggcca actacgacac cgacgaccgg tttggcttct gccccagcga      840

gagactctac acccaggacg gcaatgctga tgggaaaccc tgccagtttc cattcatctt      900

ccaaggccaa tcctactccg cctgcaccac ggacggtcgc tccgacggct accgctggtg      960

cgccaccacc gccaactacg accgggacaa gctcttcggc ttctgcccga cccgagctga     1020

ctcgacggtg atggggggca actcggcggg ggagctgtgc gtcttcccct tcactttcct     1080

gggtaaggag tactcgacct gtaccagcga gggccgcgga gatgggcgcc tctggtgcgc     1140

taccacctcg aactttgaca gcgacaagaa gtggggcttc tgcccggacc aaggatacag     1200

tttgttcctc gtggcggcgc atgagttcgg ccacgcgctg ggcttagatc attcctcagt     1260

gccggaggcg ctcatgtacc ctatgtaccg cttcactgag gggcccccct tgcataagga     1320

cgacgtgaat ggcatccggc acctctatgg tcctcgccct gaacctgagc cacggcctcc     1380

aaccaccacc acaccgcagc ccacggctcc cccgacggtc tgccccaccg gaccccccac     1440

tgtccacccc tcagagcgcc ccacagctgg ccccacaggt cccccctcag ctggccccac     1500

aggtcccccc actgctggcc cttctacggc cactactgtg cctttgagtc cggtggacga     1560

tgcctgcaac gtgaacatct tcgacgccat cgcggagatt gggaaccagc tgtatttgtt     1620

caaggatggg aagtactggc gattctctga gggcaggggg agccggccgc agggcccctt     1680

ccttatcgcc gacaagtggc ccgcgctgcc ccgcaagctg gactcggtct ttgaggagcg     1740

gctctccaag aagcttttct tcttctctgg gcgccaggtg tgggtgtaca caggcgcgtc     1800

ggtgctgggc ccgaggcgtc tggacaagct gggcctggga gccgacgtgg cccaggtgac     1860

cggggccctc cggagtggca gggggaagat gctgctgttc agcgggcggc gcctctggag     1920

gttcgacgtg aaggcgcaga tggtggatcc ccggagcgcc agcgaggtgg accggatgtt     1980

ccccggggtg cctttggaca cgcacgacgt cttccagtac cgagagaaag cctatttctg     2040

ccaggaccgc ttctactggc gcgtgagttc ccggagtgag ttgaaccagg tggaccaagt     2100

gggctacgtg acctatgaca tcctgcagtg ccctgaggac tagggctccc gtcctgcttt     2160

ggcagtgcca tgtaaatccc cactgggacc aaccctgggg aaggagccag tttgccggat     2220

acaaactggt attctgttct ggaggaaagg gaggagtgga ggtgggctgg gccctctctt     2280

ctcacctttg ttttttgttg gagtgtttct aataaacttg gattctctaa cctttaaaaa     2340

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   2387


<210>  38
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys 
1               5                   10                  15      


Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro 
            20                  25                  30          


Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr 
        35                  40                  45              


Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser 
    50                  55                  60                  


Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu 
65                  70                  75                  80  


Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr 
                85                  90                  95      


Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly 
            100                 105                 110         


Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr 
        115                 120                 125             


Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala 
    130                 135                 140                 


Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr 
145                 150                 155                 160 


Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly 
                165                 170                 175     


Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe 
            180                 185                 190         


Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu 
        195                 200                 205             


Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn 
    210                 215                 220                 


Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser 
225                 230                 235                 240 


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys 
                245                 250                 255     


Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro 
            260                 265                 270         


Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys 
        275                 280                 285             


Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr 
    290                 295                 300                 


Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr 
305                 310                 315                 320 


Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr 
                325                 330                 335     


Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr 
            340                 345                 350         


Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp 
        355                 360                 365             


Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys 
    370                 375                 380                 


Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
385                 390                 395                 400 


His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 
                405                 410                 415     


Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His 
            420                 425                 430         


Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu 
        435                 440                 445             


Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro 
    450                 455                 460                 


Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg 
465                 470                 475                 480 


Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro 
                485                 490                 495     


Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val 
            500                 505                 510         


Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly 
        515                 520                 525             


Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu 
    530                 535                 540                 


Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp 
545                 550                 555                 560 


Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu Glu Arg Leu Ser 
                565                 570                 575     


Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly 
            580                 585                 590         


Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala 
        595                 600                 605             


Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met 
    610                 615                 620                 


Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln 
625                 630                 635                 640 


Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly 
                645                 650                 655     


Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr 
            660                 665                 670         


Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu 
        675                 680                 685             


Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys 
    690                 695                 700                 


Pro Glu Asp 
705         


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  39
uugucgcugu caaaguucga g                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  40
uucuugucgc ugucaaaguu c                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  41
uucaacucac uccgggaacu c                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  42
uucacgucgu ccuuaugcaa g                                                 21


<210>  43
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  43
ccggtcttgt cgctgtcaaa gttcggaccg g                                      31


<210>  44
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  44
ccggtcttat tagaaacact ccaacgaccg g                                      31


<210>  45
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  45
ccggtcattc acgtcgtcct tatgcgaccg g                                      31


<210>  46
<211>  1828
<212>  DNA
<213>  Homo sapiens

<400>  46
ctacaaggag gcaggcaaga cagcaaggca tagagacaac atagagctaa gtaaagccag       60

tggaaatgaa gagtcttcca atcctactgt tgctgtgcgt ggcagtttgc tcagcctatc      120

cattggatgg agctgcaagg ggtgaggaca ccagcatgaa ccttgttcag aaatatctag      180

aaaactacta cgacctcaaa aaagatgtga aacagtttgt taggagaaag gacagtggtc      240

ctgttgttaa aaaaatccga gaaatgcaga agttccttgg attggaggtg acggggaagc      300

tggactccga cactctggag gtgatgcgca agcccaggtg tggagttcct gatgttggtc      360

acttcagaac ctttcctggc atcccgaagt ggaggaaaac ccaccttaca tacaggattg      420

tgaattatac accagatttg ccaaaagatg ctgttgattc tgctgttgag aaagctctga      480

aagtctggga agaggtgact ccactcacat tctccaggct gtatgaagga gaggctgata      540

taatgatctc ttttgcagtt agagaacatg gagactttta cccttttgat ggacctggaa      600

atgttttggc ccatgcctat gcccctgggc cagggattaa tggagatgcc cactttgatg      660

atgatgaaca atggacaaag gatacaacag ggaccaattt atttctcgtt gctgctcatg      720

aaattggcca ctccctgggt ctctttcact cagccaacac tgaagctttg atgtacccac      780

tctatcactc actcacagac ctgactcggt tccgcctgtc tcaagatgat ataaatggca      840

ttcagtccct ctatggacct ccccctgact cccctgagac ccccctggta cccacggaac      900

ctgtccctcc agaacctggg acgccagcca actgtgatcc tgctttgtcc tttgatgctg      960

tcagcactct gaggggagaa atcctgatct ttaaagacag gcacttttgg cgcaaatccc     1020

tcaggaagct tgaacctgaa ttgcatttga tctcttcatt ttggccatct cttccttcag     1080

gcgtggatgc cgcatatgaa gttactagca aggacctcgt tttcattttt aaaggaaatc     1140

aattctgggc tatcagagga aatgaggtac gagctggata cccaagaggc atccacaccc     1200

taggtttccc tccaaccgtg aggaaaatcg atgcagccat ttctgataag gaaaagaaca     1260

aaacatattt ctttgtagag gacaaatact ggagatttga tgagaagaga aattccatgg     1320

agccaggctt tcccaagcaa atagctgaag actttccagg gattgactca aagattgatg     1380

ctgtttttga agaatttggg ttcttttatt tctttactgg atcttcacag ttggagtttg     1440

acccaaatgc aaagaaagtg acacacactt tgaagagtaa cagctggctt aattgttgaa     1500

agagatatgt agaaggcaca atatgggcac tttaaatgaa gctaataatt cttcacctaa     1560

gtctctgtga attgaaatgt tcgttttctc ctgcctgtgc tgtgactcga gtcacactca     1620

agggaacttg agcgtgaatc tgtatcttgc cggtcatttt tatgttatta cagggcattc     1680

aaatgggctg ctgcttagct tgcaccttgt cacatagagt gatctttccc aagagaaggg     1740

gaagcactcg tgtgcaacag acaagtgact gtatctgtgt agactatttg cttatttaat     1800

aaagacgatt tgtcagttat tttatctt                                        1828


<210>  47
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Lys Ser Leu Pro Ile Leu Leu Leu Leu Cys Val Ala Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Asp Gly Ala Ala Arg Gly Glu Asp Thr Ser Met Asn 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Asn Tyr Tyr Asp Leu Lys Lys Asp Val 
        35                  40                  45              


Lys Gln Phe Val Arg Arg Lys Asp Ser Gly Pro Val Val Lys Lys Ile 
    50                  55                  60                  


Arg Glu Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp 
65                  70                  75                  80  


Ser Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Gly His Phe Arg Thr Phe Pro Gly Ile Pro Lys Trp Arg Lys Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Lys Asp 
        115                 120                 125             


Ala Val Asp Ser Ala Val Glu Lys Ala Leu Lys Val Trp Glu Glu Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Ala Val Arg Glu His Gly Asp Phe Tyr Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Asn Val Leu Ala His Ala Tyr Ala Pro Gly Pro Gly Ile Asn 
            180                 185                 190         


Gly Asp Ala His Phe Asp Asp Asp Glu Gln Trp Thr Lys Asp Thr Thr 
        195                 200                 205             


Gly Thr Asn Leu Phe Leu Val Ala Ala His Glu Ile Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr 
225                 230                 235                 240 


His Ser Leu Thr Asp Leu Thr Arg Phe Arg Leu Ser Gln Asp Asp Ile 
                245                 250                 255     


Asn Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Asp Ser Pro Glu Thr 
            260                 265                 270         


Pro Leu Val Pro Thr Glu Pro Val Pro Pro Glu Pro Gly Thr Pro Ala 
        275                 280                 285             


Asn Cys Asp Pro Ala Leu Ser Phe Asp Ala Val Ser Thr Leu Arg Gly 
    290                 295                 300                 


Glu Ile Leu Ile Phe Lys Asp Arg His Phe Trp Arg Lys Ser Leu Arg 
305                 310                 315                 320 


Lys Leu Glu Pro Glu Leu His Leu Ile Ser Ser Phe Trp Pro Ser Leu 
                325                 330                 335     


Pro Ser Gly Val Asp Ala Ala Tyr Glu Val Thr Ser Lys Asp Leu Val 
            340                 345                 350         


Phe Ile Phe Lys Gly Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val 
        355                 360                 365             


Arg Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr 
    370                 375                 380                 


Val Arg Lys Ile Asp Ala Ala Ile Ser Asp Lys Glu Lys Asn Lys Thr 
385                 390                 395                 400 


Tyr Phe Phe Val Glu Asp Lys Tyr Trp Arg Phe Asp Glu Lys Arg Asn 
                405                 410                 415     


Ser Met Glu Pro Gly Phe Pro Lys Gln Ile Ala Glu Asp Phe Pro Gly 
            420                 425                 430         


Ile Asp Ser Lys Ile Asp Ala Val Phe Glu Glu Phe Gly Phe Phe Tyr 
        435                 440                 445             


Phe Phe Thr Gly Ser Ser Gln Leu Glu Phe Asp Pro Asn Ala Lys Lys 
    450                 455                 460                 


Val Thr His Thr Leu Lys Ser Asn Ser Trp Leu Asn Cys 
465                 470                 475         


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  48
uucaucauca ucaaaguggg                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  49
uaauaacaua aaaaugaccg                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  50
uagucuacac agauacaguc                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  51
uauaucaucu ugagacaggc                                                   20


<210>  52
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  52
ccggtctata tcatcttgag acaggcgacc gg                                     32


<210>  53
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  53
ccggtctttc tcttctcatc aaatctgacc gg                                     32


<210>  54
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  54
ccggtctaac aaactgtttc acatctgacc gg                                     32


<210>  55
<211>  2943
<212>  DNA
<213>  Homo sapiens

<400>  55
accaggcaac accattgaag gctcatatgt aaaaatccat gccttccttt ctcccaatct       60

ccattcccaa acttagccac tggcttctgg ctgaggcctt acgcatacct cccggggctt      120

gcacacacct tcttctacag aagacacacc ttgggcatat cctacagaag accaggcttc      180

tctctggtcc ttggtagagg gctactttac tgtaacaggg ccagggtgga gagttctctc      240

ctgaagctcc atcccctcta taggaaatgt gttgacaata ttcagaagag taagaggatc      300

aagacttctt tgtgctcaaa taccactgtt ctcttctcta ccctgcccta accaggagct      360

tgtcacccca aactctgagg tgatttatgc cttaatcaag caaacttccc tcttcagaaa      420

agatggctca ttttccctca aaagttgcca ggagctgcca agtattctgc caattcaccc      480

tggagcacaa tcaacaaatt cagccagaac acaactacag ctactattag aactattatt      540

attaataaat tcctctccaa atctagcccc ttgacttcgg atttcacgat ttctcccttc      600

ctcctagaaa cttgataagt ttcccgcgct tccctttttc taagactaca tgtttgtcat      660

cttataaagc aaaggggtga ataaatgaac caaatcaata acttctggaa tatctgcaaa      720

caacaataat atcagctatg ccatctttca ctattttagc cagtatcgag ttgaatgaac      780

atagaaaaat acaaaactga attcttccct gtaaattccc cgttttgacg acgcacttgt      840

agccacgtag ccacgcctac ttaagacaat tacaaaaggc gaagaagact gactcaggct      900

taagctgcca gccagagagg gagtcatttc attggcgttt gagtcagcaa agaagtcaag      960

atggccaaag ttccagacat gtttgaagac ctgaagaact gttacagtga aaatgaagaa     1020

gacagttcct ccattgatca tctgtctctg aatcagaaat ccttctatca tgtaagctat     1080

ggcccactcc atgaaggctg catggatcaa tctgtgtctc tgagtatctc tgaaacctct     1140

aaaacatcca agcttacctt caaggagagc atggtggtag tagcaaccaa cgggaaggtt     1200

ctgaagaaga gacggttgag tttaagccaa tccatcactg atgatgacct ggaggccatc     1260

gccaatgact cagaggaaga aatcatcaag cctaggtcag caccttttag cttcctgagc     1320

aatgtgaaat acaactttat gaggatcatc aaatacgaat tcatcctgaa tgacgccctc     1380

aatcaaagta taattcgagc caatgatcag tacctcacgg ctgctgcatt acataatctg     1440

gatgaagcag tgaaatttga catgggtgct tataagtcat caaaggatga tgctaaaatt     1500

accgtgattc taagaatctc aaaaactcaa ttgtatgtga ctgcccaaga tgaagaccaa     1560

ccagtgctgc tgaaggagat gcctgagata cccaaaacca tcacaggtag tgagaccaac     1620

ctcctcttct tctgggaaac tcacggcact aagaactatt tcacatcagt tgcccatcca     1680

aacttgttta ttgccacaaa gcaagactac tgggtgtgct tggcaggggg gccaccctct     1740

atcactgact ttcagatact ggaaaaccag gcgtaggtct ggagtctcac ttgtctcact     1800

tgtgcagtgt tgacagttca tatgtaccat gtacatgaag aagctaaatc ctttactgtt     1860

agtcatttgc tgagcatgta ctgagccttg taattctaaa tgaatgttta cactctttgt     1920

aagagtggaa ccaacactaa catataatgt tgttatttaa agaacaccct atattttgca     1980

tagtaccaat cattttaatt attattcttc ataacaattt taggaggacc agagctactg     2040

actatggcta ccaaaaagac tctacccata ttacagatgg gcaaattaag gcataagaaa     2100

actaagaaat atgcacaata gcagttgaaa caagaagcca cagacctagg atttcatgat     2160

ttcatttcaa ctgtttgcct tctactttta agttgctgat gaactcttaa tcaaatagca     2220

taagtttctg ggacctcagt tttatcattt tcaaaatgga gggaataata cctaagcctt     2280

cctgccgcaa cagtttttta tgctaatcag ggaggtcatt ttggtaaaat acttcttgaa     2340

gccgagcctc aagatgaagg caaagcacga aatgttattt tttaattatt atttatatat     2400

gtatttataa atatatttaa gataattata atatactata tttatgggaa ccccttcatc     2460

ctctgagtgt gaccaggcat cctccacaat agcagacagt gttttctggg ataagtaagt     2520

ttgatttcat taatacaggg cattttggtc caagttgtgc ttatcccata gccaggaaac     2580

tctgcattct agtacttggg agacctgtaa tcatataata aatgtacatt aattaccttg     2640

agccagtaat tggtccgatc tttgactctt ttgccattaa acttacctgg gcattcttgt     2700

ttcaattcca cctgcaatca agtcctacaa gctaaaatta gatgaactca actttgacaa     2760

ccatgagacc actgttatca aaactttctt ttctggaatg taatcaatgt ttcttctagg     2820

ttctaaaaat tgtgatcaga ccataatgtt acattattat caacaatagt gattgataga     2880

gtgttatcag tcataactaa ataaagcttg caacaaaatt ctctgacaaa aaaaaaaaaa     2940

aaa                                                                   2943


<210>  56
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Lys Val Pro Asp Met Phe Glu Asp Leu Lys Asn Cys Tyr Ser 
1               5                   10                  15      


Glu Asn Glu Glu Asp Ser Ser Ser Ile Asp His Leu Ser Leu Asn Gln 
            20                  25                  30          


Lys Ser Phe Tyr His Val Ser Tyr Gly Pro Leu His Glu Gly Cys Met 
        35                  40                  45              


Asp Gln Ser Val Ser Leu Ser Ile Ser Glu Thr Ser Lys Thr Ser Lys 
    50                  55                  60                  


Leu Thr Phe Lys Glu Ser Met Val Val Val Ala Thr Asn Gly Lys Val 
65                  70                  75                  80  


Leu Lys Lys Arg Arg Leu Ser Leu Ser Gln Ser Ile Thr Asp Asp Asp 
                85                  90                  95      


Leu Glu Ala Ile Ala Asn Asp Ser Glu Glu Glu Ile Ile Lys Pro Arg 
            100                 105                 110         


Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg 
        115                 120                 125             


Ile Ile Lys Tyr Glu Phe Ile Leu Asn Asp Ala Leu Asn Gln Ser Ile 
    130                 135                 140                 


Ile Arg Ala Asn Asp Gln Tyr Leu Thr Ala Ala Ala Leu His Asn Leu 
145                 150                 155                 160 


Asp Glu Ala Val Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys Asp 
                165                 170                 175     


Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu Tyr 
            180                 185                 190         


Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met Pro 
        195                 200                 205             


Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe Phe 
    210                 215                 220                 


Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His Pro 
225                 230                 235                 240 


Asn Leu Phe Ile Ala Thr Lys Gln Asp Tyr Trp Val Cys Leu Ala Gly 
                245                 250                 255     


Gly Pro Pro Ser Ile Thr Asp Phe Gln Ile Leu Glu Asn Gln Ala 
            260                 265                 270     


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  57
uuucuauguu cauucaacuc                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  58
ucauucaacu cgauacuggc                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  59
uucauucaac ucgauacugg                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  60
uaauaguucu aauaguagcu                                                   20


<210>  61
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  61
ccggtctttc ttagttttct tatgccgacc gg                                     32


<210>  62
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  62
ccggtctaat agttctaata gtagcgaccg g                                      31


<210>  63
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  63
ccggtctatg aactgtcaac actgcgaccg g                                      31


<210>  64
<211>  1498
<212>  DNA
<213>  Homo sapiens

<400>  64
accaaacctc ttcgaggcac aaggcacaac aggctgctct gggattctct tcagccaatc       60

ttcattgctc aagtgtctga agcagccatg gcagaagtac ctgagctcgc cagtgaaatg      120

atggcttatt acagtggcaa tgaggatgac ttgttctttg aagctgatgg ccctaaacag      180

atgaagtgct ccttccagga cctggacctc tgccctctgg atggcggcat ccagctacga      240

atctccgacc accactacag caagggcttc aggcaggccg cgtcagttgt tgtggccatg      300

gacaagctga ggaagatgct ggttccctgc ccacagacct tccaggagaa tgacctgagc      360

accttctttc ccttcatctt tgaagaagaa cctatcttct tcgacacatg ggataacgag      420

gcttatgtgc acgatgcacc tgtacgatca ctgaactgca cgctccggga ctcacagcaa      480

aaaagcttgg tgatgtctgg tccatatgaa ctgaaagctc tccacctcca gggacaggat      540

atggagcaac aagtggtgtt ctccatgtcc tttgtacaag gagaagaaag taatgacaaa      600

atacctgtgg ccttgggcct caaggaaaag aatctgtacc tgtcctgcgt gttgaaagat      660

gataagccca ctctacagct ggagagtgta gatcccaaaa attacccaaa gaagaagatg      720

gaaaagcgat ttgtcttcaa caagatagaa atcaataaca agctggaatt tgagtctgcc      780

cagttcccca actggtacat cagcacctct caagcagaaa acatgcccgt cttcctggga      840

gggaccaaag gcggccagga tataactgac ttcaccatgc aatttgtgtc ttcctaaaga      900

gagctgtacc cagagagtcc tgtgctgaat gtggactcaa tccctagggc tggcagaaag      960

ggaacagaaa ggtttttgag tacggctata gcctggactt tcctgttgtc tacaccaatg     1020

cccaactgcc tgccttaggg tagtgctaag aggatctcct gtccatcagc caggacagtc     1080

agctctctcc tttcagggcc aatccccagc ccttttgttg agccaggcct ctctcacctc     1140

tcctactcac ttaaagcccg cctgacagaa accacggcca catttggttc taagaaaccc     1200

tctgtcattc gctcccacat tctgatgagc aaccgcttcc ctatttattt atttatttgt     1260

ttgtttgttt tattcattgg tctaatttat tcaaaggggg caagaagtag cagtgtctgt     1320

aaaagagcct agtttttaat agctatggaa tcaattcaat ttggactggt gtgctctctt     1380

taaatcaagt cctttaatta agactgaaaa tatataagct cagattattt aaatgggaat     1440

atttataaat gagcaaatat catactgttc aatggttctg aaataaactt cactgaag       1498


<210>  65
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  66
uuaucaucuu ucaacacgca g                                                 21


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  67
uuuuacagac acugcuacuu c                                                 21


<210>  68
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  68
uuugucauua cuuucuucuc c                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  69
uacagacacu gcuacuucuu g                                                 21


<210>  70
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  70
ccggtctttt gtcattactt tcttctcgac cgg                                    33


<210>  71
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  71
ccggtctttc agtcttaatt aaaggacgac cgg                                    33


<210>  72
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  72
ccggtcttac ataaattaac tcagctgacc gg                                     32


<210>  73
<211>  1201
<212>  DNA
<213>  Homo sapiens

<400>  73
aatattagag tctcaacccc caataaatat aggactggag atgtctgagg ctcattctgc       60

cctcgagccc accgggaacg aaagagaagc tctatctccc ctccaggagc ccagctatga      120

actccttctc cacaagcgcc ttcggtccag ttgccttctc cctggggctg ctcctggtgt      180

tgcctgctgc cttccctgcc ccagtacccc caggagaaga ttccaaagat gtagccgccc      240

cacacagaca gccactcacc tcttcagaac gaattgacaa acaaattcgg tacatcctcg      300

acggcatctc agccctgaga aaggagacat gtaacaagag taacatgtgt gaaagcagca      360

aagaggcact ggcagaaaac aacctgaacc ttccaaagat ggctgaaaaa gatggatgct      420

tccaatctgg attcaatgag gagacttgcc tggtgaaaat catcactggt cttttggagt      480

ttgaggtata cctagagtac ctccagaaca gatttgagag tagtgaggaa caagccagag      540

ctgtgcagat gagtacaaaa gtcctgatcc agttcctgca gaaaaaggca aagaatctag      600

atgcaataac cacccctgac ccaaccacaa atgccagcct gctgacgaag ctgcaggcac      660

agaaccagtg gctgcaggac atgacaactc atctcattct gcgcagcttt aaggagttcc      720

tgcagtccag cctgagggct cttcggcaaa tgtagcatgg gcacctcaga ttgttgttgt      780

taatgggcat tccttcttct ggtcagaaac ctgtccactg ggcacagaac ttatgttgtt      840

ctctatggag aactaaaagt atgagcgtta ggacactatt ttaattattt ttaatttatt      900

aatatttaaa tatgtgaagc tgagttaatt tatgtaagtc atatttatat ttttaagaag      960

taccacttga aacattttat gtattagttt tgaaataata atggaaagtg gctatgcagt     1020

ttgaatatcc tttgtttcag agccagatca tttcttggaa agtgtaggct tacctcaaat     1080

aaatggctaa cttatacata tttttaaaga aatatttata ttgtatttat ataatgtata     1140

aatggttttt ataccaataa atggcatttt aaaaaattca gcaaaaaaaa aaaaaaaaaa     1200

a                                                                     1201


<210>  74
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  75
uaaaauagug uccuaacgcu c                                                 21


<210>  76
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  76
ucacuacucu caaaucuguu c                                                 21


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  77
uuacucuugu uacaugucuc c                                                 21


<210>  78
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  78
uaacgcucau acuuuuaguu c                                                 21


<210>  79
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  79
ccggtcttac tcttgttaca tgtcyccgac ctt                                    33


<210>  80
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  80
ccggtcttac tcttgttaca tgtctccgac ctt                                    33


<210>  81
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  81
ccggtctaca taaaatgttt caagtgggac ctt                                    33


<210>  82
<211>  1718
<212>  DNA
<213>  Homo sapiens

<400>  82
gagggtgcat aagttctcta gtagggtgat gatataaaaa gccaccggag cactccataa       60

ggcacaaact ttcagagaca gcagagcaca caagcttcta ggacaagagc caggaagaaa      120

ccaccggaag gaaccatctc actgtgtgta aacatgactt ccaagctggc cgtggctctc      180

ttggcagcct tcctgatttc tgcagctctg tgtgaaggtg cagttttgcc aaggagtgct      240

aaagaactta gatgtcagtg cataaagaca tactccaaac ctttccaccc caaatttatc      300

aaagaactga gagtgattga gagtggacca cactgcgcca acacagaaat tattgtaaag      360

ctttctgatg gaagagagct ctgtctggac cccaaggaaa actgggtgca gagggttgtg      420

gagaagtttt tgaagagggc tgagaattca taaaaaaatt cattctctgt ggtatccaag      480

aatcagtgaa gatgccagtg aaacttcaag caaatctact tcaacacttc atgtattgtg      540

tgggtctgtt gtagggttgc cagatgcaat acaagattcc tggttaaatt tgaatttcag      600

taaacaatga atagtttttc attgtaccat gaaatatcca gaacatactt atatgtaaag      660

tattatttat ttgaatctac aaaaaacaac aaataatttt taaatataag gattttccta      720

gatattgcac gggagaatat acaaatagca aaattgaggc caagggccaa gagaatatcc      780

gaactttaat ttcaggaatt gaatgggttt gctagaatgt gatatttgaa gcatcacata      840

aaaatgatgg gacaataaat tttgccataa agtcaaattt agctggaaat cctggatttt      900

tttctgttaa atctggcaac cctagtctgc tagccaggat ccacaagtcc ttgttccact      960

gtgccttggt ttctccttta tttctaagtg gaaaaagtat tagccaccat cttacctcac     1020

agtgatgttg tgaggacatg tggaagcact ttaagttttt tcatcataac ataaattatt     1080

ttcaagtgta acttattaac ctatttatta tttatgtatt tatttaagca tcaaatattt     1140

gtgcaagaat ttggaaaaat agaagatgaa tcattgattg aatagttata aagatgttat     1200

agtaaattta ttttatttta gatattaaat gatgttttat tagataaatt tcaatcaggg     1260

tttttagatt aaacaaacaa acaattgggt acccagttaa attttcattt cagataaaca     1320

acaaataatt ttttagtata agtacattat tgtttatctg aaattttaat tgaactaaca     1380

atcctagttt gatactccca gtcttgtcat tgccagctgt gttggtagtg ctgtgttgaa     1440

ttacggaata atgagttaga actattaaaa cagccaaaac tccacagtca atattagtaa     1500

tttcttgctg gttgaaactt gtttattatg tacaaataga ttcttataat attatttaaa     1560

tgactgcatt tttaaataca aggctttata tttttaactt taagatgttt ttatgtgctc     1620

tccaaatttt ttttactgtt tctgattgta tggaaatata aaagtaaata tgaaacattt     1680

aaaatataat ttgttgtcaa agtaaaaaaa aaaaaaaa                             1718


<210>  83
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  84
uuuguuuaau cuaaaaaccc                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  85
uuuacacaca gugagauggu                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  86
uucaaauauc acauucuagc                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcialy synthesized

<400>  87
uuaugcacug acaucuaagu                                                   20


<210>  88
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  88
ccggtctatc acattctagc aaacccgacc gg                                     32


<210>  89
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  89
ccggtctact agagaactta tgcaccgacc gg                                     32


<210>  90
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  90
ccggtctagt tctaactcat tattccgacc gg                                     32


<210>  91
<211>  5170
<212>  DNA
<213>  Homo sapiens

<400>  91
gtggccggcg gccggagccg actcggagcg cgcggcgccg gccgggagga gccggagagc       60

ggccgggccg ggcggtgggg gcgccggcct gccccgcgcg ccccagggag cggcaggaat      120

gtgacaatcg cgcgcccgcg caccgaagca ctcctcgctc ggctcctagg gctctcgccc      180

ctctgagctg agccgggttc cgcccggggc tgggatccca tcaccctcca cggccgtccg      240

tccaggtaga cgcaccctct gaagatggtg actccctcct gagaagctgg accccttggt      300

aaaagacaag gccttctcca agaagaatat gaaagtgtta ctcagactta tttgtttcat      360

agctctactg atttcttctc tggaggctga taaatgcaag gaacgtgaag aaaaaataat      420

tttagtgtca tctgcaaatg aaattgatgt tcgtccctgt cctcttaacc caaatgaaca      480

caaaggcact ataacttggt ataaagatga cagcaagaca cctgtatcta cagaacaagc      540

ctccaggatt catcaacaca aagagaaact ttggtttgtt cctgctaagg tggaggattc      600

aggacattac tattgcgtgg taagaaattc atcttactgc ctcagaatta aaataagtgc      660

aaaatttgtg gagaatgagc ctaacttatg ttataatgca caagccatat ttaagcagaa      720

actacccgtt gcaggagacg gaggacttgt gtgcccttat atggagtttt ttaaaaatga      780

aaataatgag ttacctaaat tacagtggta taaggattgc aaacctctac ttcttgacaa      840

tatacacttt agtggagtca aagataggct catcgtgatg aatgtggctg aaaagcatag      900

agggaactat acttgtcatg catcctacac atacttgggc aagcaatatc ctattacccg      960

ggtaatagaa tttattactc tagaggaaaa caaacccaca aggcctgtga ttgtgagccc     1020

agctaatgag acaatggaag tagacttggg atcccagata caattgatct gtaatgtcac     1080

cggccagttg agtgacattg cttactggaa gtggaatggg tcagtaattg atgaagatga     1140

cccagtgcta ggggaagact attacagtgt ggaaaatcct gcaaacaaaa gaaggagtac     1200

cctcatcaca gtgcttaata tatcggaaat tgaaagtaga ttttataaac atccatttac     1260

ctgttttgcc aagaatacac atggtataga tgcagcatat atccagttaa tatatccagt     1320

cactaatttc cagaagcaca tgattggtat atgtgtcacg ttgacagtca taattgtgtg     1380

ttctgttttc atctataaaa tcttcaagat tgacattgtg ctttggtaca gggattcctg     1440

ctatgatttt ctcccaataa aagcttcaga tggaaagacc tatgacgcat atatactgta     1500

tccaaagact gttggggaag ggtctacctc tgactgtgat atttttgtgt ttaaagtctt     1560

gcctgaggtc ttggaaaaac agtgtggata taagctgttc atttatggaa gggatgacta     1620

cgttggggaa gacattgttg aggtcattaa tgaaaacgta aagaaaagca gaagactgat     1680

tatcatttta gtcagagaaa catcaggctt cagctggctg ggtggttcat ctgaagagca     1740

aatagccatg tataatgctc ttgttcagga tggaattaaa gttgtcctgc ttgagctgga     1800

gaaaatccaa gactatgaga aaatgccaga atcgattaaa ttcattaagc agaaacatgg     1860

ggctatccgc tggtcagggg actttacaca gggaccacag tctgcaaaga caaggttctg     1920

gaagaatgtc aggtaccaca tgccagtcca gcgacggtca ccttcatcta aacaccagtt     1980

actgtcacca gccactaagg agaaactgca aagagaggct cacgtgcctc tcgggtagca     2040

tggagaagtt gccaagagtt ctttaggtgc ctcctgtctt atggcgttgc aggccaggtt     2100

atgcctcatg ctgacttgca gagttcatgg aatgtaacta tatcatcctt tatccctgag     2160

gtcacctgga atcagattat taagggaata agccatgacg tcaatagcag cccagggcac     2220

ttcagagtag agggcttggg aagatctttt aaaaaggcag taggcccggt gtggtggctc     2280

acgcctataa tcccagcact ttgggaggct gaagtgggtg gatcaccaga ggtcaggagt     2340

tcgagaccag cccagccaac atggcaaaac cccatctcta ctaaaaatac aaaaatgagc     2400

taggcatggt ggcacacgcc tgtaatccca gctacacctg aggctgaggc aggagaattg     2460

cttgaaccgg ggagacggag gttgcagtga gccgagtttg ggccactgca ctctagcctg     2520

gcaacagagc aagactccgt ctcaaaaaaa gggcaataaa tgccctctct gaatgtttga     2580

actgccaaga aaaggcatgg agacagcgaa ctagaagaaa gggcaagaag gaaatagcca     2640

ccgtctacag atggcttagt taagtcatcc acagcccaag ggcggggcta tgccttgtct     2700

ggggaccctg tagagtcact gaccctggag cggctctcct gagaggtgct gcaggcaaag     2760

tgagactgac acctcactga ggaagggaga catattcttg gagaactttc catctgcttg     2820

tattttccat acacatcccc agccagaagt tagtgtccga agaccgaatt ttattttaca     2880

gagcttgaaa actcacttca atgaacaaag ggattctcca ggattccaaa gttttgaagt     2940

catcttagct ttccacagga gggagagaac ttaaaaaagc aacagtagca gggaattgat     3000

ccacttctta atgctttcct ccctggcatg accatcctgt cctttgttat tatcctgcat     3060

tttacgtctt tggaggaaca gctccctagt ggcttcctcc gtctgcaatg tcccttgcac     3120

agcccacaca tgaaccatcc ttcccatgat gccgctcttc tgtcatcccg ctcctgctga     3180

aacacctccc aggggctcca cctgttcagg agctgaagcc catgctttcc caccagcatg     3240

tcactcccag accacctccc tgccctgtcc tccagcttcc cctcgctgtc ctgctgtgtg     3300

aattcccagg ttggcctggt ggccatgtcg cctgccccca gcactcctct gtctctgctc     3360

ttgcctgcac ccttcctcct cctttgccta ggaggccttc tcgcattttc tctagctgat     3420

cagaatttta ccaaaattca gaacatcctc caattccaca gtctctggga gactttccct     3480

aagaggcgac ttcctctcca gccttctctc tctggtcagg cccactgcag agatggtggt     3540

gagcacatct gggaggctgg tctccctcca gctggaattg ctgctctctg agggagaggc     3600

tgtggtggct gtctctgtcc ctcactgcct tccaggagca atttgcacat gtaacataga     3660

tttatgtaat gctttatgtt taaaaacatt ccccaattat cttatttaat ttttgcaatt     3720

attctaattt tatatataga gaaagtgacc tattttttaa aaaaatcaca ctctaagttc     3780

tattgaacct aggacttgag cctccatttc tggcttctag tctggtgttc tgagtacttg     3840

atttcaggtc aataacggtc ccccctcact ccacactggc acgtttgtga gaagaaatga     3900

cattttgcta ggaagtgacc gagtctagga atgcttttat tcaagacacc aaattccaaa     3960

cttctaaatg ttggaatttt caaaaattgt gtttagattt tatgaaaaac tcttctactt     4020

tcatctattc tttccctaga ggcaaacatt tcttaaaatg tttcattttc attaaaaatg     4080

aaagccaaat ttatatgcca ccgattgcag gacacaagca cagttttaag agttgtatga     4140

acatggagag gacttttggt ttttatattt ctcgtattta atatgggtga acaccaactt     4200

ttatttggaa taataatttt cctcctaaac aaaaacacat tgagtttaag tctctgactc     4260

ttgcctttcc acctgctttc tcctgggccc gctttgcctg cttgaaggaa cagtgctgtt     4320

ctggagctgc tgttccaaca gacagggcct agctttcatt tgacacacag actacagcca     4380

gaagcccatg gagcagggat gtcacgtctt gaaaagccta ttagatgttt tacaaattta     4440

attttgcaga ttattttagt ctgtcatcca gaaaatgtgt cagcatgcat agtgctaaga     4500

aagcaagcca atttggaaac ttaggttagt gacaaaattg gccagagagt gggggtgatg     4560

atgaccaaga attacaagta gaatggcagc tggaatttaa ggagggacaa gaatcaatgg     4620

ataagcgtgg gtggaggaag atccaaacag aaaagtgcaa agttattccc catcttccaa     4680

gggttgaatt ctggaggaag aagacacatt cctagttccc cgtgaacttc ctttgactta     4740

ttgtccccac taaaacaaaa caaaaaactt ttaatgcctt ccacattaat tagattttct     4800

tgcagttttt ttatggcatt tttttaaaga tgccctaagt gttgaagaag agtttgcaaa     4860

tgcaacaaaa tatttaatta ccggttgtta aaactggttt agcacaattt atattttccc     4920

tctcttgcct ttcttatttg caataaaagg tattgagcca ttttttaaat gacatttttg     4980

ataaattatg tttgtactag ttgatgaagg agtttttttt aacctgttta tataattttg     5040

cagcagaagc caaatttttt gtatattaaa gcaccaaatt catgtacagc atgcatcacg     5100

gatcaataga ctgtacttat tttccaataa aattttcaaa ctttgtactg ttaaaaaaaa     5160

aaaaaaaaaa                                                            5170


<210>  92
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  93
uuucuucuca caaacgugcc                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  94
uuauaccaag uuauagugcc                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  95
uuguaaaaca ucuaauaggc                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  96
uuuccacacu guaauagucu                                                   20


<210>  97
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  97
ccggtctttc ttctcacaaa cgtgcgaccg g                                      31


<210>  98
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  98
ccggtcttaa acacaaaaat atcacgaccg g                                      31


<210>  99
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  checmially synthesized

<400>  99
ccggtctttc cacactgtaa tagtcgaccg g                                      31


<210>  100
<211>  1686
<212>  DNA
<213>  Homo sapiens

<400>  100
cagacgctcc ctcagcaagg acagcagagg accagctaag agggagagaa gcaactacag       60

accccccctg aaaacaaccc tcagacgcca catcccctga caagctgcca ggcaggttct      120

cttcctctca catactgacc cacggctcca ccctctctcc cctggaaagg acaccatgag      180

cactgaaagc atgatccggg acgtggagct ggccgaggag gcgctcccca agaagacagg      240

ggggccccag ggctccaggc ggtgcttgtt cctcagcctc ttctccttcc tgatcgtggc      300

aggcgccacc acgctcttct gcctgctgca ctttggagtg atcggccccc agagggaaga      360

gttccccagg gacctctctc taatcagccc tctggcccag gcagtcagat catcttctcg      420

aaccccgagt gacaagcctg tagcccatgt tgtagcaaac cctcaagctg aggggcagct      480

ccagtggctg aaccgccggg ccaatgccct cctggccaat ggcgtggagc tgagagataa      540

ccagctggtg gtgccatcag agggcctgta cctcatctac tcccaggtcc tcttcaaggg      600

ccaaggctgc ccctccaccc atgtgctcct cacccacacc atcagccgca tcgccgtctc      660

ctaccagacc aaggtcaacc tcctctctgc catcaagagc ccctgccaga gggagacccc      720

agagggggct gaggccaagc cctggtatga gcccatctat ctgggagggg tcttccagct      780

ggagaagggt gaccgactca gcgctgagat caatcggccc gactatctcg actttgccga      840

gtctgggcag gtctactttg ggatcattgc cctgtgagga ggacgaacat ccaaccttcc      900

caaacgcctc ccctgcccca atccctttat taccccctcc ttcagacacc ctcaacctct      960

tctggctcaa aaagagaatt gggggcttag ggtcggaacc caagcttaga actttaagca     1020

acaagaccac cacttcgaaa cctgggattc aggaatgtgt ggcctgcaca gtgaagtgct     1080

ggcaaccact aagaattcaa actggggcct ccagaactca ctggggccta cagctttgat     1140

ccctgacatc tggaatctgg agaccaggga gcctttggtt ctggccagaa tgctgcagga     1200

cttgagaaga cctcacctag aaattgacac aagtggacct taggccttcc tctctccaga     1260

tgtttccaga cttccttgag acacggagcc cagccctccc catggagcca gctccctcta     1320

tttatgtttg cacttgtgat tatttattat ttatttatta tttatttatt tacagatgaa     1380

tgtatttatt tgggagaccg gggtatcctg ggggacccaa tgtaggagct gccttggctc     1440

agacatgttt tccgtgaaaa cggagctgaa caataggctg ttcccatgta gccccctggc     1500

ctctgtgcct tcttttgatt atgtttttta aaatatttat ctgattaagt tgtctaaaca     1560

atgctgattt ggtgaccaac tgtcactcat tgctgagcct ctgctcccca ggggagttgt     1620

gtctgtaatc gccctactat tcagtggcga gaaataaagt ttgcttagaa aagaaaaaaa     1680

aaaaaa                                                                1686


<210>  101
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  102
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  102
aauaaauaau cacaagugc                                                    19


<210>  103
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  103
uaaaaaacau aaucaaaag                                                    19


<210>  104
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  104
uaauaaauaa ucacaagug                                                    19


<210>  105
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  105
uuuucuuuuc uaagcaaac                                                    19


<210>  106
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synhtesized

<400>  106
ccggtcaaac ataatcaaaa gaagggaccg g                                      31


<210>  107
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  107
ccggtctaaa aaacataatc aaaaggaccg g                                      31


<210>  108
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  108
ccggtctatt ttaaaaaaca taatcgaccg g                                      31


<210>  109
<211>  3677
<212>  DNA
<213>  Homo sapiens

<400>  109
tcgcggaggc ttggggcagc cgggtagctc ggaggtcgtg gcgctggggg ctagcaccag       60

cgctctgtcg ggaggcgcag cggttaggtg gaccggtcag cggactcacc ggccagggcg      120

ctcggtgctg gaatttgata ttcattgatc cgggttttat ccctcttctt ttttcttaaa      180

catttttttt taaaactgta ttgtttctcg ttttaattta tttttgcttg ccattcccca      240

cttgaatcgg gccgacggct tggggagatt gctctacttc cccaaatcac tgtggatttt      300

ggaaaccagc agaaagagga aagaggtagc aagagctcca gagagaagtc gaggaagaga      360

gagacggggt cagagagagc gcgcgggcgt gcgagcagcg aaagcgacag gggcaaagtg      420

agtgacctgc ttttgggggt gaccgccgga gcgcggcgtg agccctcccc cttgggatcc      480

cgcagctgac cagtcgcgct gacggacaga cagacagaca ccgcccccag ccccagctac      540

cacctcctcc ccggccggcg gcggacagtg gacgcggcgg cgagccgcgg gcaggggccg      600

gagcccgcgc ccggaggcgg ggtggagggg gtcggggctc gcggcgtcgc actgaaactt      660

ttcgtccaac ttctgggctg ttctcgcttc ggaggagccg tggtccgcgc gggggaagcc      720

gagccgagcg gagccgcgag aagtgctagc tcgggccggg aggagccgca gccggaggag      780

ggggaggagg aagaagagaa ggaagaggag agggggccgc agtggcgact cggcgctcgg      840

aagccgggct catggacggg tgaggcggcg gtgtgcgcag acagtgctcc agccgcgcgc      900

gctccccagg ccctggcccg ggcctcgggc cggggaggaa gagtagctcg ccgaggcgcc      960

gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc     1020

ggtcgggcct ccgaaaccat gaactttctg ctgtcttggg tgcattggag ccttgccttg     1080

ctgctctacc tccaccatgc caagtggtcc caggctgcac ccatggcaga aggaggaggg     1140

cagaatcatc acgaagtggt gaagttcatg gatgtctatc agcgcagcta ctgccatcca     1200

atcgagaccc tggtggacat cttccaggag taccctgatg agatcgagta catcttcaag     1260

ccatcctgtg tgcccctgat gcgatgcggg ggctgctgca atgacgaggg cctggagtgt     1320

gtgcccactg aggagtccaa catcaccatg cagattatgc ggatcaaacc tcaccaaggc     1380

cagcacatag gagagatgag cttcctacag cacaacaaat gtgaatgcag accaaagaaa     1440

gatagagcaa gacaagaaaa aaaatcagtt cgaggaaagg gaaaggggca aaaacgaaag     1500

cgcaagaaat cccggtataa gtcctggagc gtgtacgttg gtgcccgctg ctgtctaatg     1560

ccctggagcc tccctggccc ccatccctgt gggccttgct cagagcggag aaagcatttg     1620

tttgtacaag atccgcagac gtgtaaatgt tcctgcaaaa acacagactc gcgttgcaag     1680

gcgaggcagc ttgagttaaa cgaacgtact tgcagatgtg acaagccgag gcggtgagcc     1740

gggcaggagg aaggagcctc cctcagggtt tcgggaacca gatctctcac caggaaagac     1800

tgatacagaa cgatcgatac agaaaccacg ctgccgccac cacaccatca ccatcgacag     1860

aacagtcctt aatccagaaa cctgaaatga aggaagagga gactctgcgc agagcacttt     1920

gggtccggag ggcgagactc cggcggaagc attcccgggc gggtgaccca gcacggtccc     1980

tcttggaatt ggattcgcca ttttattttt cttgctgcta aatcaccgag cccggaagat     2040

tagagagttt tatttctggg attcctgtag acacacccac ccacatacat acatttatat     2100

atatatatat tatatatata taaaaataaa tatctctatt ttatatatat aaaatatata     2160

tattcttttt ttaaattaac agtgctaatg ttattggtgt cttcactgga tgtatttgac     2220

tgctgtggac ttgagttggg aggggaatgt tcccactcag atcctgacag ggaagaggag     2280

gagatgagag actctggcat gatctttttt ttgtcccact tggtggggcc agggtcctct     2340

cccctgccca ggaatgtgca aggccagggc atgggggcaa atatgaccca gttttgggaa     2400

caccgacaaa cccagccctg gcgctgagcc tctctacccc aggtcagacg gacagaaaga     2460

cagatcacag gtacagggat gaggacaccg gctctgacca ggagtttggg gagcttcagg     2520

acattgctgt gctttgggga ttccctccac atgctgcacg cgcatctcgc ccccaggggc     2580

actgcctgga agattcagga gcctgggcgg ccttcgctta ctctcacctg cttctgagtt     2640

gcccaggaga ccactggcag atgtcccggc gaagagaaga gacacattgt tggaagaagc     2700

agcccatgac agctcccctt cctgggactc gccctcatcc tcttcctgct ccccttcctg     2760

gggtgcagcc taaaaggacc tatgtcctca caccattgaa accactagtt ctgtcccccc     2820

aggagacctg gttgtgtgtg tgtgagtggt tgaccttcct ccatcccctg gtccttccct     2880

tcccttcccg aggcacagag agacagggca ggatccacgt gcccattgtg gaggcagaga     2940

aaagagaaag tgttttatat acggtactta tttaatatcc ctttttaatt agaaattaaa     3000

acagttaatt taattaaaga gtagggtttt ttttcagtat tcttggttaa tatttaattt     3060

caactattta tgagatgtat cttttgctct ctcttgctct cttatttgta ccggtttttg     3120

tatataaaat tcatgtttcc aatctctctc tccctgatcg gtgacagtca ctagcttatc     3180

ttgaacagat atttaatttt gctaacactc agctctgccc tccccgatcc cctggctccc     3240

cagcacacat tcctttgaaa taaggtttca atatacatct acatactata tatatatttg     3300

gcaacttgta tttgtgtgta tatatatata tatatgttta tgtatatatg tgattctgat     3360

aaaatagaca ttgctattct gttttttata tgtaaaaaca aaacaagaaa aaatagagaa     3420

ttctacatac taaatctctc tcctttttta attttaatat ttgttatcat ttatttattg     3480

gtgctactgt ttatccgtaa taattgtggg gaaaagatat taacatcacg tctttgtctc     3540

tagtgcagtt tttcgagata ttccgtagta catatttatt tttaaacaac gacaaagaaa     3600

tacagatata tcttaaaaaa aaaaaagcat tttgtattaa agaatttaat tctgatctca     3660

aaaaaaaaaa aaaaaaa                                                    3677


<210>  110
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys 
            340                 345                 350         


Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser 
        355                 360                 365             


Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys 
    370                 375                 380                 


Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu 
385                 390                 395                 400 


Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
                405                 410         


<210>  111
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  111
uaaaacucuc uaaucuuccg g                                                 21


<210>  112
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  112
uuccuucucu ucuuccuccu c                                                 21


<210>  113
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  113
uauacacaca aauacaaguu g                                                 21


<210>  114
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  114
uuaaaacgag aaacaauaca g                                                 21


<210>  115
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  115
ccggtctaaa actctctaat cttccgaccg g                                      31


<210>  116
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synhesized

<400>  116
ccggtctttg atccgcataa tctgcgaccg g                                      31


<210>  117
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  117
ccggtcttga aattaaatat taaccgaccg g                                      31


<210>  118
<211>  2583
<212>  DNA
<213>  Homo sapiens

<400>  118
agccggtccc cgccgccgcc gcccttcgcg ccctgggcca tctccctccc acctccctcc       60

gcggagcagc cagacagcga gggccccggc cgggggcagg ggggacgccc cgtccggggc      120

acccccccgg ctctgagccg cccgcggggc cggcctcggc ccggagcgga ggaaggagtc      180

gccgaggagc agcctgaggc cccagagtct gagacgagcc gccgccgccc ccgccactgc      240

ggggaggagg gggaggagga gcgggaggag ggacgagctg gtcgggagaa gaggaaaaaa      300

acttttgaga cttttccgtt gccgctggga gccggaggcg cggggacctc ttggcgcgac      360

gctgccccgc gaggaggcag gacttgggga ccccagaccg cctccctttg ccgccgggga      420

cgcttgctcc ctccctgccc cctacacggc gtccctcagg cgcccccatt ccggaccagc      480

cctcgggagt cgccgacccg gcctcccgca aagacttttc cccagacctc gggcgcaccc      540

cctgcacgcc gccttcatcc ccggcctgtc tcctgagccc ccgcgcatcc tagacccttt      600

ctcctccagg agacggatct ctctccgacc tgccacagat cccctattca agaccaccca      660

ccttctggta ccagatcgcg cccatctagg ttatttccgt gggatactga gacacccccg      720

gtccaagcct cccctccacc actgcgccct tctccctgag gacctcagct ttccctcgag      780

gccctcctac cttttgccgg gagaccccca gcccctgcag gggcggggcc tccccaccac      840

accagccctg ttcgcgctct cggcagtgcc ggggggcgcc gcctccccca tgccgccctc      900

cgggctgcgg ctgctgccgc tgctgctacc gctgctgtgg ctactggtgc tgacgcctgg      960

ccggccggcc gcgggactat ccacctgcaa gactatcgac atggagctgg tgaagcggaa     1020

gcgcatcgag gccatccgcg gccagatcct gtccaagctg cggctcgcca gccccccgag     1080

ccagggggag gtgccgcccg gcccgctgcc cgaggccgtg ctcgccctgt acaacagcac     1140

ccgcgaccgg gtggccgggg agagtgcaga accggagccc gagcctgagg ccgactacta     1200

cgccaaggag gtcacccgcg tgctaatggt ggaaacccac aacgaaatct atgacaagtt     1260

caagcagagt acacacagca tatatatgtt cttcaacaca tcagagctcc gagaagcggt     1320

acctgaaccc gtgttgctct cccgggcaga gctgcgtctg ctgaggctca agttaaaagt     1380

ggagcagcac gtggagctgt accagaaata cagcaacaat tcctggcgat acctcagcaa     1440

ccggctgctg gcacccagcg actcgccaga gtggttatct tttgatgtca ccggagttgt     1500

gcggcagtgg ttgagccgtg gaggggaaat tgagggcttt cgccttagcg cccactgctc     1560

ctgtgacagc agggataaca cactgcaagt ggacatcaac gggttcacta ccggccgccg     1620

aggtgacctg gccaccattc atggcatgaa ccggcctttc ctgcttctca tggccacccc     1680

gctggagagg gcccagcatc tgcaaagctc ccggcaccgc cgagccctgg acaccaacta     1740

ttgcttcagc tccacggaga agaactgctg cgtgcggcag ctgtacattg acttccgcaa     1800

ggacctcggc tggaagtgga tccacgagcc caagggctac catgccaact tctgcctcgg     1860

gccctgcccc tacatttgga gcctggacac gcagtacagc aaggtcctgg ccctgtacaa     1920

ccagcataac ccgggcgcct cggcggcgcc gtgctgcgtg ccgcaggcgc tggagccgct     1980

gcccatcgtg tactacgtgg gccgcaagcc caaggtggag cagctgtcca acatgatcgt     2040

gcgctcctgc aagtgcagct gaggtcccgc cccgccccgc cccgccccgg caggcccggc     2100

cccaccccgc cccgcccccg ctgccttgcc catgggggct gtatttaagg acacccgtgc     2160

cccaagccca cctggggccc cattaaagat ggagagagga ctgcggatct ctgtgtcatt     2220

gggcgcctgc ctggggtctc catccctgac gttcccccac tcccactccc tctctctccc     2280

tctctgcctc ctcctgcctg tctgcactat tcctttgccc ggcatcaagg cacaggggac     2340

cagtggggaa cactactgta gttagatcta tttattgagc accttgggca ctgttgaagt     2400

gccttacatt aatgaactca ttcagtcacc atagcaacac tctgagatgc agggactctg     2460

ataacaccca ttttaaaggt gaggaaacaa gcccagagag gttaagggag gagttcctgc     2520

ccaccaggaa cctgctttag tgggggatag tgaagaagac aataaaagat agtagttcag     2580

gcc                                                                   2583


<210>  119
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  120
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synhtesized

<400>  120
uauugucuuc uucacuauc                                                    19


<210>  121
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  121
uagaucuaac uacaguagu                                                    19


<210>  122
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  122
uauaugcugu guguacucu                                                    19


<210>  123
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  123
uauauaugcu guguguacu                                                    19


<210>  124
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  124
ccggtcatat atgctgtgtg tactcgaccg g                                      31


<210>  125
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  125
ccggtctttt attgtcttct tcactgaccg g                                      31


<210>  126
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  126
ccggtctata tatgctgtgt gtactgaccg g                                      31


<210>  127
<211>  5966
<212>  DNA
<213>  Homo sapiens

<400>  127
gtgatgttat ctgctggcag cagaaggttc gctccgagcg gagctccaga agctcctgac       60

aagagaaaga cagattgaga tagagataga aagagaaaga gagaaagaga cagcagagcg      120

agagcgcaag tgaaagaggc aggggagggg gatggagaat attagcctga cggtctaggg      180

agtcatccag gaacaaactg aggggctgcc cggctgcaga caggaggaga cagagaggat      240

ctattttagg gtggcaagtg cctacctacc ctaagcgagc aattccacgt tggggagaag      300

ccagcagagg ttgggaaagg gtgggagtcc aagggagccc ctgcgcaacc ccctcaggaa      360

taaaactccc cagccagggt gtcgcaaggg ctgccgttgt gatccgcagg gggtgaacgc      420

aaccgcgacg gctgatcgtc tgtggctggg ttggcgtttg gagcaagaga aggaggagca      480

ggagaaggag ggagctggag gctggaagcg tttgcaagcg gcggcggcag caacgtggag      540

taaccaagcg ggtcagcgcg cgcccgccag ggtgtaggcc acggagcgca gctcccagag      600

caggatccgc gccgcctcag cagcctctgc ggcccctgcg gcacccgacc gagtaccgag      660

cgccctgcga agcgcaccct cctccccgcg gtgcgctggg ctcgccccca gcgcgcgcac      720

acgcacacac acacacacac acacacacgc acgcacacac gtgtgcgctt ctctgctccg      780

gagctgctgc tgctcctgct ctcagcgccg cagtggaagg caggaccgaa ccgctccttc      840

tttaaatata taaatttcag cccaggtcag cctcggcggc ccccctcacc gcgctcccgg      900

cgcccctccc gtcagttcgc cagctgccag ccccgggacc ttttcatctc ttcccttttg      960

gccggaggag ccgagttcag atccgccact ccgcacccga gactgacaca ctgaactcca     1020

cttcctcctc ttaaatttat ttctacttaa tagccactcg tctctttttt tccccatctc     1080

attgctccaa gaattttttt cttcttactc gccaaagtca gggttccctc tgcccgtccc     1140

gtattaatat ttccactttt ggaactactg gccttttctt tttaaaggaa ttcaagcagg     1200

atacgttttt ctgttgggca ttgactagat tgtttgcaaa agtttcgcat caaaaacaac     1260

aacaacaaaa aaccaaacaa ctctccttga tctatacttt gagaattgtt gatttctttt     1320

ttttattctg acttttaaaa acaacttttt tttccacttt tttaaaaaat gcactactgt     1380

gtgctgagcg cttttctgat cctgcatctg gtcacggtcg cgctcagcct gtctacctgc     1440

agcacactcg atatggacca gttcatgcgc aagaggatcg aggcgatccg cgggcagatc     1500

ctgagcaagc tgaagctcac cagtccccca gaagactatc ctgagcccga ggaagtcccc     1560

ccggaggtga tttccatcta caacagcacc agggacttgc tccaggagaa ggcgagccgg     1620

agggcggccg cctgcgagcg cgagaggagc gacgaagagt actacgccaa ggaggtttac     1680

aaaatagaca tgccgccctt cttcccctcc gaaactgtct gcccagttgt tacaacaccc     1740

tctggctcag tgggcagctt gtgctccaga cagtcccagg tgctctgtgg gtaccttgat     1800

gccatcccgc ccactttcta cagaccctac ttcagaattg ttcgatttga cgtctcagca     1860

atggagaaga atgcttccaa tttggtgaaa gcagagttca gagtctttcg tttgcagaac     1920

ccaaaagcca gagtgcctga acaacggatt gagctatatc agattctcaa gtccaaagat     1980

ttaacatctc caacccagcg ctacatcgac agcaaagttg tgaaaacaag agcagaaggc     2040

gaatggctct ccttcgatgt aactgatgct gttcatgaat ggcttcacca taaagacagg     2100

aacctgggat ttaaaataag cttacactgt ccctgctgca cttttgtacc atctaataat     2160

tacatcatcc caaataaaag tgaagaacta gaagcaagat ttgcaggtat tgatggcacc     2220

tccacatata ccagtggtga tcagaaaact ataaagtcca ctaggaaaaa aaacagtggg     2280

aagaccccac atctcctgct aatgttattg ccctcctaca gacttgagtc acaacagacc     2340

aaccggcgga agaagcgtgc tttggatgcg gcctattgct ttagaaatgt gcaggataat     2400

tgctgcctac gtccacttta cattgatttc aagagggatc tagggtggaa atggatacac     2460

gaacccaaag ggtacaatgc caacttctgt gctggagcat gcccgtattt atggagttca     2520

gacactcagc acagcagggt cctgagctta tataatacca taaatccaga agcatctgct     2580

tctccttgct gcgtgtccca agatttagaa cctctaacca ttctctacta cattggcaaa     2640

acacccaaga ttgaacagct ttctaatatg attgtaaagt cttgcaaatg cagctaaaat     2700

tcttggaaaa gtggcaagac caaaatgaca atgatgatga taatgatgat gacgacgaca     2760

acgatgatgc ttgtaacaag aaaacataag agagccttgg ttcatcagtg ttaaaaaatt     2820

tttgaaaagg cggtactagt tcagacactt tggaagtttg tgttctgttt gttaaaactg     2880

gcatctgaca caaaaaaagt tgaaggcctt attctacatt tcacctactt tgtaagtgag     2940

agagacaaga agcaaatttt ttttaaagaa aaaaataaac actggaagaa tttattagtg     3000

ttaattatgt gaacaacgac aacaacaaca acaacaacaa acaggaaaat cccattaagt     3060

ggagttgctg tacgtaccgt tcctatcccg cgcctcactt gatttttctg tattgctatg     3120

caataggcac ccttcccatt cttactctta gagttaacag tgagttattt attgtgtgtt     3180

actatataat gaacgtttca ttgcccttgg aaaataaaac aggtgtataa agtggagacc     3240

aaatactttg ccagaaactc atggatggct taaggaactt gaactcaaac gagccagaaa     3300

aaaagaggtc atattaatgg gatgaaaacc caagtgagtt attatatgac cgagaaagtc     3360

tgcattaaga taaagaccct gaaaacacat gttatgtatc agctgcctaa ggaagcttct     3420

tgtaaggtcc aaaaactaaa aagactgtta ataaaagaaa ctttcagtca gaataagtct     3480

gtaagttttt ttttttcttt ttaattgtaa atggttcttt gtcagtttag taaaccagtg     3540

aaatgttgaa atgttttgac atgtactggt caaacttcag accttaaaat attgctgtat     3600

agctatgcta taggtttttt cctttgtttt ggtatatgta accataccta tattattaaa     3660

atagatggat atagaagcca gcataattga aaacacatct gcagatctct tttgcaaact     3720

attaaatcaa aacattaact actttatgtg taatgtgtaa atttttacca tattttttat     3780

attctgtaat aatgtcaact atgatttaga ttgacttaaa tttgggctct ttttaatgat     3840

cactcacaaa tgtatgtttc ttttagctgg ccagtacttt tgagtaaagc ccctatagtt     3900

tgacttgcac tacaaatgca tttttttttt aataacattt gccctacttg tgctttgtgt     3960

ttctttcatt attatgacat aagctacctg ggtccacttg tcttttcttt tttttgtttc     4020

acagaaaaga tgggttcgag ttcagtggtc ttcatcttcc aagcatcatt actaaccaag     4080

tcagacgtta acaaattttt atgttaggaa aaggaggaat gttatagata catagaaaat     4140

tgaagtaaaa tgttttcatt ttagcaagga tttagggttc taactaaaac tcagaatctt     4200

tattgagtta agaaaagttt ctctaccttg gtttaatcaa tatttttgta aaatcctatt     4260

gttattacaa agaggacact tcataggaaa catctttttc tttagtcagg tttttaatat     4320

tcagggggaa attgaaagat atatatttta gtcgattttt caaaagggga aaaaagtcca     4380

ggtcagcata agtcattttg tgtatttcac tgaagttata aggtttttat aaatgttctt     4440

tgaaggggaa aaggcacaag ccaatttttc ctatgatcaa aaaattcttt ctttcctctg     4500

agtgagagtt atctatatct gaggctaaag tttaccttgc tttaataaat aatttgccac     4560

atcattgcag aagaggtatc ctcatgctgg ggttaataga atatgtcagt ttatcacttg     4620

tcgcttattt agctttaaaa taaaaattaa taggcaaagc aatggaatat ttgcagtttc     4680

acctaaagag cagcataagg aggcgggaat ccaaagtgaa gttgtttgat atggtctact     4740

tcttttttgg aatttcctga ccattaatta aagaattgga tttgcaagtt tgaaaactgg     4800

aaaagcaaga gatgggatgc cataatagta aacagccctt gtgttggatg taacccaatc     4860

ccagatttga gtgtgtgttg attatttttt tgtcttccac ttttctatta tgtgtaaatc     4920

acttttattt ctgcagacat tttcctctca gataggatga cattttgttt tgtattattt     4980

tgtctttcct catgaatgca ctgataatat tttaaatgct ctattttaag atctcttgaa     5040

tctgtttttt ttttttttaa tttgggggtt ctgtaaggtc tttatttccc ataagtaaat     5100

attgccatgg gaggggggtg gaggtggcaa ggaaggggtg aagtgctagt atgcaagtgg     5160

gcagcaatta tttttgtgtt aatcagcagt acaatttgat cgttggcatg gttaaaaaat     5220

ggaatataag attagctgtt ttgtattttg atgaccaatt acgctgtatt ttaacacgat     5280

gtatgtctgt ttttgtggtg ctctagtggt aaataaatta tttcgatgat atgtggatgt     5340

ctttttccta tcagtaccat catcgagtct agaaaacacc tgtgatgcaa taagactatc     5400

tcaagctgga aaagtcatac cacctttccg attgccctct gtgctttctc ccttaaggac     5460

agtcacttca gaagtcatgc tttaaagcac aagagtcagg ccatatccat caaggataga     5520

agaaatccct gtgccgtctt tttattccct tatttattgc tatttggtaa ttgtttgaga     5580

tttagtttcc atccagcttg actgccgacc agaaaaaatg cagagagatg tttgcaccat     5640

gctttggctt tctggttcta tgttctgcca acgccagggc caaaagaact ggtctagaca     5700

gtatcccctg tagccccata acttggatag ttgctgagcc agccagatat aacaagagcc     5760

acgtgctttc tggggttggt tgtttgggat cagctacttg cctgtcagtt tcactggtac     5820

cactgcacca caaacaaaaa aacccaccct atttcctcca atttttttgg ctgctaccta     5880

caagaccaga ctcctcaaac gagttgccaa tctcttaata aataggatta ataaaaaaag     5940

taattgtgac tcaaaaaaaa aaaaaa                                          5966


<210>  128
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  128

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Thr Val Cys Pro Val Val Thr Thr Pro Ser Gly Ser Val 
        115                 120                 125             


Gly Ser Leu Cys Ser Arg Gln Ser Gln Val Leu Cys Gly Tyr Leu Asp 
    130                 135                 140                 


Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg Ile Val Arg Phe 
145                 150                 155                 160 


Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu Val Lys Ala Glu 
                165                 170                 175     


Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg Val Pro Glu Gln 
            180                 185                 190         


Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp Leu Thr Ser Pro 
        195                 200                 205             


Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr Arg Ala Glu Gly 
    210                 215                 220                 


Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His Glu Trp Leu His 
225                 230                 235                 240 


His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu His Cys Pro Cys 
                245                 250                 255     


Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro Asn Lys Ser Glu 
            260                 265                 270         


Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr Ser Thr Tyr Thr 
        275                 280                 285             


Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys Lys Asn Ser Gly 
    290                 295                 300                 


Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser Tyr Arg Leu Glu 
305                 310                 315                 320 


Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu Asp Ala Ala Tyr 
                325                 330                 335     


Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg Pro Leu Tyr Ile 
            340                 345                 350         


Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly 
        355                 360                 365             


Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr Leu Trp Ser Ser 
    370                 375                 380                 


Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn Thr Ile Asn Pro 
385                 390                 395                 400 


Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp Leu Glu Pro Leu 
                405                 410                 415     


Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu Gln Leu Ser 
            420                 425                 430         


Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
        435                 440         


<210>  129
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  129
uaucucuauc ucaaucuguc                                                   20


<210>  130
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  checmially synthesized

<400>  130
uucuaucucu aucucaaucu                                                   20


<210>  131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synhtesized

<400>  131
uucucuuucu aucucuaucu                                                   20


<210>  132
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  132
ucuaucucua ucucaaucug                                                   20


<210>  133
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesizerd

<400>  133
ccggtcttct atctctatct caatcgaccg g                                      31


<210>  134
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  134
ccggtctatc tctatctcaa tctgtgaccg g                                      31


<210>  135
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  135
ccggtcttct ctttctatct ctatcgaccg g                                      31


<210>  136
<211>  7321
<212>  DNA
<213>  Homo sapiens

<400>  136
ttttgtagat aaatgtgagg attttctcta aatccctctt ctgtttgcta aatctcactg       60

tcactgctaa attcagagca gatagagcct gcgcaatgga ataaagtcct caaaattgaa      120

atgtgacatt gctctcaaca tctcccatct ctctggattt ctttttgctt cattattcct      180

gctaaccaat tcattttcag actttgtact tcagaagcaa tgggaaaaat cagcagtctt      240

ccaacccaat tatttaagtg ctgcttttgt gatttcttga aggtgaagat gcacaccatg      300

tcctcctcgc atctcttcta cctggcgctg tgcctgctca ccttcaccag ctctgccacg      360

gctggaccgg agacgctctg cggggctgag ctggtggatg ctcttcagtt cgtgtgtgga      420

gacaggggct tttatttcaa caagcccaca gggtatggct ccagcagtcg gagggcgcct      480

cagacaggca tcgtggatga gtgctgcttc cggagctgtg atctaaggag gctggagatg      540

tattgcgcac ccctcaagcc tgccaagtca gctcgctctg tccgtgccca gcgccacacc      600

gacatgccca agacccagaa ggaagtacat ttgaagaacg caagtagagg gagtgcagga      660

aacaagaact acaggatgta ggaagaccct cctgaggagt gaagagtgac atgccaccgc      720

aggatccttt gctctgcacg agttacctgt taaactttgg aacacctacc aaaaaataag      780

tttgataaca tttaaaagat gggcgtttcc cccaatgaaa tacacaagta aacattccaa      840

cattgtcttt aggagtgatt tgcaccttgc aaaaatggtc ctggagttgg tagattgctg      900

ttgatctttt atcaataatg ttctatagaa aagaaaaaaa aaatatatat atatatatat      960

cttagtccct gcctctcaag agccacaaat gcatgggtgt tgtatagatc cagttgcact     1020

aaattcctct ctgaatcttg gctgctggag ccattcattc agcaaccttg tctaagtggt     1080

ttatgaattg tttccttatt tgcacttctt tctacacaac tcgggctgtt tgttttacag     1140

tgtctgataa tcttgttagt ctatacccac cacctccctt cataaccttt atatttgccg     1200

aatttggcct cctcaaaagc agcagcaagt cgtcaagaag cacaccaatt ctaacccaca     1260

agattccatc tgtggcattt gtaccaaata taagttggat gcattttatt ttagacacaa     1320

agctttattt ttccacatca tgcttacaaa aaagaataat gcaaatagtt gcaactttga     1380

ggccaatcat ttttaggcat atgttttaaa catagaaagt ttcttcaact caaaagagtt     1440

ccttcaaatg atgagttaat gtgcaaccta attagtaact ttcctctttt tattttttcc     1500

atatagagca ctatgtaaat ttagcatatc aattatacag gatatatcaa acagtatgta     1560

aaactctgtt ttttagtata atggtgctat tttgtagttt gttatatgaa agagtctggc     1620

caaaacggta atacgtgaaa gcaaaacaat aggggaagcc tggagccaaa gatgacacaa     1680

ggggaagggt actgaaaaca ccatccattt gggaaagaag gcaaagtccc cccagttatg     1740

ccttccaaga ggaacttcag acacaaaagt ccactgatgc aaattggact ggcgagtcca     1800

gagaggaaac tgtggaatgg aaaaagcaga aggctaggaa ttttagcagt cctggtttct     1860

ttttctcatg gaagaaatga acatctgcca gctgtgtcat ggactcacca ctgtgtgacc     1920

ttgggcaagt cacttcacct ctctgtgcct cagtttcctc atctgcaaaa tgggggcaat     1980

atgtcatcta cctacctcaa aggggtggta taaggtttaa aaagataaag attcagattt     2040

tttttaccct gggttgctgt aagggtgcaa catcagggcg cttgagttgc tgagatgcaa     2100

ggaattctat aaataaccca ttcatagcat agctagagat tggtgaattg aatgctcctg     2160

acatctcagt tcttgtcagt gaagctatcc aaataactgg ccaactagtt gttaaaagct     2220

aacagctcaa tctcttaaaa cacttttcaa aatatgtggg aagcatttga ttttcaattt     2280

gattttgaat tctgcatttg gttttatgaa tacaaagata agtgaaaaga gagaaaggaa     2340

aagaaaaagg agaaaaacaa agagatttct accagtgaaa ggggaattaa ttactctttg     2400

ttagcactca ctgactcttc tatgcagtta ctacatatct agtaaaacct cgtttaatac     2460

tataaataat attctattca ttttgaaaaa cacaatgatt ccttcttttc taggcaatat     2520

aaggaaagtg atccaaaatt tgaaatatta aaataatatc taataaaaag tcacaaagtt     2580

atcttcttta acaaacttta ctcttattct tagctgtata tacatttttt taaaagtttg     2640

ttaaaatatg cttgactaga gtttccagtt gaaaggcaaa aacttccatc acaacaagaa     2700

atttcccatg cctgctcaga agggtagccc ctagctctct gtgaatgtgt tttatccatt     2760

caactgaaaa ttggtatcaa gaaagtccac tggttagtgt actagtccat catagcctag     2820

aaaatgatcc ctatctgcag atcaagattt tctcattaga acaatgaatt atccagcatt     2880

cagatctttc tagtcacctt agaacttttt ggttaaaagt acccaggctt gattatttca     2940

tgcaaattct atattttaca ttcttggaaa gtctatatga aaaacaaaaa taacatcttc     3000

agtttttctc ccactgggtc acctcaagga tcagaggcca ggaaaaaaaa aaaaaagact     3060

ccctggatct ctgaatatat gcaaaaagaa ggccccattt agtggagcca gcaatcctgt     3120

tcagtcaaca agtattttaa ctctcagtcc aacattattt gaattgagca cctcaagcat     3180

gcttagcaat gttctaatca ctatggacag atgtaaaaga aactatacat catttttgcc     3240

ctctgcctgt tttccagaca tacaggttct gtggaataag atactggact cctcttccca     3300

agatggcact tctttttatt tcttgtcccc agtgtgtacc ttttaaaatt attccctctc     3360

aacaaaactt tataggcagt cttctgcaga cttaacgtgt tttctgtcat agttagatgt     3420

gataattcta agagtgtcta tgacttattt ccttcactta attctatcca cagtcaaaaa     3480

tcccccaagg aggaaagctg aaagatgcac tgccatatta tctttcttaa ctttttccaa     3540

cacataatcc tctccaactg gattataaat aaattgaaaa taactcatta taccaattca     3600

ctattttatt ttttaatgaa ttaaaactag aaaacaaatt gatgcaaacc ctggaagtca     3660

gttgattact atatactaca gcagaatgac tcagatttca tagaaaggag caaccaaaat     3720

gtcacaaccc aaaactttac aagctttgct tcagaattag attgctttat aattcttgaa     3780

tgaggcaatt tcaagatatt tgtaaaagaa cagtaaacat tggtaagaat gagctttcaa     3840

ctcataggct tatttccaat ttaattgacc atactggata cttaggtcaa atttctgttc     3900

tctcttcccc aaataatatt aaagtattat ttgaactttt taagatgagg cagttcccct     3960

gaaaaagtta atgcagctct ccatcagaat ccactcttct agggatatga aaatctctta     4020

acacccaccc tacatacaca gacacacaca cacacacaca cacacacaca cacacacaca     4080

ttcaccctaa ggatccaatg gaatactgaa aagaaatcac ttccttgaaa attttattaa     4140

aaaacaaaca aacaaacaaa aagcctgtcc acccttgaga atccttcctc tccttggaac     4200

gtcaatgttt gtgtagatga aaccatctca tgctctgtgg ctccagggtt tctgttacta     4260

ttttatgcac ttgggagaag gcttagaata aaagatgtag cacattttgc tttcccattt     4320

attgtttggc cagctatgcc aatgtggtgc tattgtttct ttaagaaagt acttgactaa     4380

aaaaaaaaga aaaaaagaaa aaaaagaaag catagacata tttttttaaa gtataaaaac     4440

aacaattcta tagatagatg gcttaataaa atagcattag gtctatctag ccaccaccac     4500

ctttcaactt tttatcactc acaagtagtg tactgttcac caaattgtga atttgggggt     4560

gcaggggcag gagttggaaa ttttttaaag ttagaaggct ccattgtttt gttggctctc     4620

aaacttagca aaattagcaa tatattatcc aatcttctga acttgatcaa gagcatggag     4680

aataaacgcg ggaaaaaaga tcttataggc aaatagaaga atttaaaaga taagtaagtt     4740

ccttattgat ttttgtgcac tctgctctaa aacagatatt cagcaagtgg agaaaataag     4800

aacaaagaga aaaaatacat agatttacct gcaaaaaata gcttctgcca aatccccctt     4860

gggtattctt tggcatttac tggtttatag aagacattct cccttcaccc agacatctca     4920

aagagcagta gctctcatga aaagcaatca ctgatctcat ttgggaaatg ttggaaagta     4980

tttccttatg agatgggggt tatctactga taaagaaaga atttatgaga aattgttgaa     5040

agagatggct aacaatctgt gaagattttt tgtttcttgt ttttgttttt tttttttttt     5100

tactttatac agtctttatg aatttcttaa tgttcaaaat gacttggttc ttttcttctt     5160

tttttatatc agaatgagga ataataagtt aaacccacat agactcttta aaactatagg     5220

ctagatagaa atgtatgttt gacttgttga agctataatc agactattta aaatgttttg     5280

ctatttttaa tcttaaaaga ttgtgctaat ttattagagc agaacctgtt tggctctcct     5340

cagaagaaag aatctttcca ttcaaatcac atggctttcc accaatattt tcaaaagata     5400

aatctgattt atgcaatggc atcatttatt ttaaaacaga agaattgtga aagtttatgc     5460

ccctcccttg caaagaccat aaagtccaga tctggtaggg gggcaacaac aaaaggaaaa     5520

tgttgttgat tcttggtttt ggattttgtt ttgttttcaa tgctagtgtt taatcctgta     5580

gtacatattt gcttattgct attttaatat tttataagac cttcctgtta ggtattagaa     5640

agtgatacat agatatcttt tttgtgtaat ttctatttaa aaaagagaga agactgtcag     5700

aagctttaag tgcatatggt acaggataaa gatatcaatt taaataacca attcctatct     5760

ggaacaatgc ttttgttttt taaagaaacc tctcacagat aagacagagg cccaggggat     5820

ttttgaagct gtctttattc tgcccccatc ccaacccagc ccttattatt ttagtatctg     5880

cctcagaatt ttatagaggg ctgaccaagc tgaaactcta gaattaaagg aacctcactg     5940

aaaacatata tttcacgtgt tccctctttt tttttttcct ttttgtgaga tggggtctcg     6000

cactgtcccc caggctggag tgcagtggca tgatctcggc tcactgcaac ctccacctcc     6060

tgggtttaag cgattctcct gcctcagcct cctgagtagc tgggattaca ggcacccacc     6120

actatgcccg gctaattttt tggattttta atagagacgg ggttttacca tgttggccag     6180

gttggtctca aactcctgac cttgtgattt gcccgcctca gcctcccaaa ttgctgggat     6240

tacaggcatg agccaccaca ccctgcccat gtgttccctc ttaatgtatg attacatgga     6300

tcttaaacat gatccttctc tcctcattct tcaactatct ttgatggggt ctttcaaggg     6360

gaaaaaaatc caagcttttt taaagtaaaa aaaaaaaaag agaggacaca aaaccaaatg     6420

ttactgctca actgaaatat gagttaagat ggagacagag tttctcctaa taaccggagc     6480

tgaattacct ttcactttca aaaacatgac cttccacaat ccttagaatc tgcctttttt     6540

tatattactg aggcctaaaa gtaaacatta ctcattttat tttgcccaaa atgcactgat     6600

gtaaagtagg aaaaataaaa acagagctct aaaatccctt tcaagccacc cattgacccc     6660

actcaccaac tcatagcaaa gtcacttctg ttaatccctt aatctgattt tgtttggata     6720

tttatcttgt acccgctgct aaacacactg caggagggac tctgaaacct caagctgtct     6780

acttacatct tttatctgtg tctgtgtatc atgaaaatgt ctattcaaaa tatcaaaacc     6840

tttcaaatat cacgcagctt atattcagtt tacataaagg ccccaaatac catgtcagat     6900

ctttttggta aaagagttaa tgaactatga gaattgggat tacatcatgt attttgcctc     6960

atgtattttt atcacactta taggccaagt gtgataaata aacttacaga cactgaatta     7020

atttcccctg ctactttgaa accagaaaat aatgactggc cattcgttac atctgtctta     7080

gttgaaaagc atatttttta ttaaattaat tctgattgta tttgaaatta ttattcaatt     7140

cacttatggc agaggaatat caatcctaat gacttctaaa aatgtaacta attgaatcat     7200

tatcttacat ttactgttta ataagcatat tttgaaaatg tatggctaga gtgtcataat     7260

aaaatggtat atctttcttt agtaattaca ttaaaattag tcatgtttga ttaattagtt     7320

c                                                                     7321


<210>  137
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
    130                 135                 140                 


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
145                 150             


<210>  138
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synhtesized

<400>  138
uaaacugaau auaagcugc                                                    19


<210>  139
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  139
uaaaaaaaua ugucuaugc                                                    19


<210>  140
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  140
uuuaacaggu aacucgugc                                                    19


<210>  141
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  141
uaacaaacua caaaauagc                                                    19


<210>  142
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  142
ccggtctaaa ctgaatataa gctgcggacc gg                                     32


<210>  143
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  143
ccggtcttta aattcttcta tttgccgacc gg                                     32


<210>  144
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  144
ccggtctaat caactgactt ccaggggacc gg                                     32


<210>  145
<211>  3150
<212>  DNA
<213>  Homo sapiens

<400>  145
ccacaaaggg cacttggccc cagggctagg agagcgaggg gagagcacag ccacccgcct       60

cggcggcccg ggactcggct cgactcgccg gagaatgcgc ccgaggacga cggggcgcca      120

gagccgcggt gctttcaact ggcgagcgcg aatgggggtg cactggagta aggcagagtg      180

atgcgggggg gcaactcgcc tggcaccgag atcgccgccg tgcccttccc tggacccggc      240

gtcgcccagg atggctgccc cgagccatgg gccgcggcgg agctagcgcg gagcgcccga      300

ccctcgaccc ccgagtcccg gagccggccc cgcgcggggc cacgcgtccc tcgggcgctg      360

gttcctaagg aggacgacag caccagcttc tcctttctcc cttcccttcc ctgccccgca      420

ctcctccccc tgctcgctgt tgttgtgtgt cagcacttgg ctggggactt cttgaacttg      480

cagggagaat aacttgcgca ccccactttg cgccggtgcc tttgccccag cggagcctgc      540

ttcgccatct ccgagcccca ccgcccctcc actcctcggc cttgcccgac actgagacgc      600

tgttcccagc gtgaaaagag agactgcgcg gccggcaccc gggagaagga ggaggcaaag      660

aaaaggaacg gacattcggt ccttgcgcca ggtcctttga ccagagtttt tccatgtgga      720

cgctctttca atggacgtgt ccccgcgtgc ttcttagacg gactgcggtc tcctaaaggt      780

cgaccatggt ggccgggacc cgctgtcttc tagcgttgct gcttccccag gtcctcctgg      840

gcggcgcggc tggcctcgtt ccggagctgg gccgcaggaa gttcgcggcg gcgtcgtcgg      900

gccgcccctc atcccagccc tctgacgagg tcctgagcga gttcgagttg cggctgctca      960

gcatgttcgg cctgaaacag agacccaccc ccagcaggga cgccgtggtg cccccctaca     1020

tgctagacct gtatcgcagg cactcaggtc agccgggctc acccgcccca gaccaccggt     1080

tggagagggc agccagccga gccaacactg tgcgcagctt ccaccatgaa gaatctttgg     1140

aagaactacc agaaacgagt gggaaaacaa cccggagatt cttctttaat ttaagttcta     1200

tccccacgga ggagtttatc acctcagcag agcttcaggt tttccgagaa cagatgcaag     1260

atgctttagg aaacaatagc agtttccatc accgaattaa tatttatgaa atcataaaac     1320

ctgcaacagc caactcgaaa ttccccgtga ccagactttt ggacaccagg ttggtgaatc     1380

agaatgcaag caggtgggaa agttttgatg tcacccccgc tgtgatgcgg tggactgcac     1440

agggacacgc caaccatgga ttcgtggtgg aagtggccca cttggaggag aaacaaggtg     1500

tctccaagag acatgttagg ataagcaggt ctttgcacca agatgaacac agctggtcac     1560

agataaggcc attgctagta acttttggcc atgatggaaa agggcatcct ctccacaaaa     1620

gagaaaaacg tcaagccaaa cacaaacagc ggaaacgcct taagtccagc tgtaagagac     1680

accctttgta cgtggacttc agtgacgtgg ggtggaatga ctggattgtg gctcccccgg     1740

ggtatcacgc cttttactgc cacggagaat gcccttttcc tctggctgat catctgaact     1800

ccactaatca tgccattgtt cagacgttgg tcaactctgt taactctaag attcctaagg     1860

catgctgtgt cccgacagaa ctcagtgcta tctcgatgct gtaccttgac gagaatgaaa     1920

aggttgtatt aaagaactat caggacatgg ttgtggaggg ttgtgggtgt cgctagtaca     1980

gcaaaattaa atacataaat atatatatat atatatattt tagaaaaaag aaaaaaacaa     2040

acaaacaaaa aaaccccacc ccagttgaca ctttaatatt tcccaatgaa gactttattt     2100

atggaatgga atggaaaaaa aaacagctat tttgaaaata tatttatatc tacgaaaaga     2160

agttgggaaa acaaatattt taatcagaga attattcctt aaagatttaa aatgtattta     2220

gttgtacatt ttatatgggt tcaaccccag cacatgaagt ataatggtca gatttatttt     2280

gtatttattt actattataa ccacttttta ggaaaaaaat agctaatttg tatttatatg     2340

taatcaaaag aagtatcggg tttgtacata attttccaaa aattgtagtt gttttcagtt     2400

gtgtgtattt aagatgaaaa gtctacatgg aaggttactc tggcaaagtg cttagcacgt     2460

ttgctttttt gcagtgctac tgttgagttc acaagttcaa gtccagaaaa aaaaagtgga     2520

taatccactc tgctgacttt caagattatt atattattca attctcagga atgttgcaga     2580

gtgattgtcc aatccatgag aatttacatc cttattaggt ggaatatttg gataagaacc     2640

agacattgct gatctattat agaaactctc ctcctgcccc ttaatttaca gaaagaataa     2700

agcaggatcc atagaaataa ttaggaaaac gatgaacctg caggaaagtg aatgatggtt     2760

tgttgttctt ctttcctaaa ttagtgatcc cttcaaaggg gctgatctgg ccaaagtatt     2820

caataaaacg taagatttct tcattattga tattgtggtc atatatattt aaaattgata     2880

tctcgtggcc ctcatcaagg gttggaaatt tatttgtgtt ttacctttac ctcatctgag     2940

agctctttat tctccaaaga acccagtttt ctaacttttt gcccaacacg cagcaaaatt     3000

atgcacatcg tgttttctgc ccaccctctg ttctctgacc tatcagcttg cttttctttc     3060

caaggttgtg tgtttgaaca catttctcca aatgttaaac ctatttcaga taataaatat     3120

caaatctctg gcatttcatt ctataaagtc                                      3150


<210>  146
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Val Ala Gly Thr Arg Cys Leu Leu Ala Leu Leu Leu Pro Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ala Gly Leu Val Pro Glu Leu Gly Arg Arg Lys 
            20                  25                  30          


Phe Ala Ala Ala Ser Ser Gly Arg Pro Ser Ser Gln Pro Ser Asp Glu 
        35                  40                  45              


Val Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys 
    50                  55                  60                  


Gln Arg Pro Thr Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu 
65                  70                  75                  80  


Asp Leu Tyr Arg Arg His Ser Gly Gln Pro Gly Ser Pro Ala Pro Asp 
                85                  90                  95      


His Arg Leu Glu Arg Ala Ala Ser Arg Ala Asn Thr Val Arg Ser Phe 
            100                 105                 110         


His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Thr Ser Gly Lys Thr 
        115                 120                 125             


Thr Arg Arg Phe Phe Phe Asn Leu Ser Ser Ile Pro Thr Glu Glu Phe 
    130                 135                 140                 


Ile Thr Ser Ala Glu Leu Gln Val Phe Arg Glu Gln Met Gln Asp Ala 
145                 150                 155                 160 


Leu Gly Asn Asn Ser Ser Phe His His Arg Ile Asn Ile Tyr Glu Ile 
                165                 170                 175     


Ile Lys Pro Ala Thr Ala Asn Ser Lys Phe Pro Val Thr Arg Leu Leu 
            180                 185                 190         


Asp Thr Arg Leu Val Asn Gln Asn Ala Ser Arg Trp Glu Ser Phe Asp 
        195                 200                 205             


Val Thr Pro Ala Val Met Arg Trp Thr Ala Gln Gly His Ala Asn His 
    210                 215                 220                 


Gly Phe Val Val Glu Val Ala His Leu Glu Glu Lys Gln Gly Val Ser 
225                 230                 235                 240 


Lys Arg His Val Arg Ile Ser Arg Ser Leu His Gln Asp Glu His Ser 
                245                 250                 255     


Trp Ser Gln Ile Arg Pro Leu Leu Val Thr Phe Gly His Asp Gly Lys 
            260                 265                 270         


Gly His Pro Leu His Lys Arg Glu Lys Arg Gln Ala Lys His Lys Gln 
        275                 280                 285             


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
    290                 295                 300                 


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
305                 310                 315                 320 


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
                325                 330                 335     


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
            340                 345                 350         


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
        355                 360                 365             


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
    370                 375                 380                 


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
385                 390                 395     


<210>  147
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  147
uugugaacuc aacaguagc                                                    19


<210>  148
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  148
uuaauuuugc uguacuagc                                                    19


<210>  149
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  149
uaaaacacaa auaaauuuc                                                    19


<210>  150
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  150
uucuuucugu aaauuaagg                                                    19


<210>  151
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  151
ccggtctaat acaaaataaa tctggaccgg                                        30


<210>  152
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  152
ccggtcaaaa cacaaataaa tttccgaccg g                                      31


<210>  153
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  153
ccggtcttca ttctcgtcaa ggtacgaccg g                                      31


<210>  154
<211>  1957
<212>  DNA
<213>  Homo sapiens

<400>  154
aagaggagga aggaagatgc gagaaggcag aggaggaggg agggagggaa ggagcgcgga       60

gcccggcccg gaagctaggt gagtgtggca tccgagctga gggacgcgag cctgagacgc      120

cgctgctgct ccggctgagt atctagcttg tctccccgat gggattcccg tccaagctat      180

ctcgagcctg cagcgccaca gtccccggcc ctcgcccagg ttcactgcaa ccgttcagag      240

gtccccagga gctgctgctg gcgagcccgc tactgcaggg acctatggag ccattccgta      300

gtgccatccc gagcaacgca ctgctgcagc ttccctgagc ctttccagca agtttgttca      360

agattggctg tcaagaatca tggactgtta ttatatgcct tgttttctgt caagacacca      420

tgattcctgg taaccgaatg ctgatggtcg ttttattatg ccaagtcctg ctaggaggcg      480

cgagccatgc tagtttgata cctgagacgg ggaagaaaaa agtcgccgag attcagggcc      540

acgcgggagg acgccgctca gggcagagcc atgagctcct gcgggacttc gaggcgacac      600

ttctgcagat gtttgggctg cgccgccgcc cgcagcctag caagagtgcc gtcattccgg      660

actacatgcg ggatctttac cggcttcagt ctggggagga ggaggaagag cagatccaca      720

gcactggtct tgagtatcct gagcgcccgg ccagccgggc caacaccgtg aggagcttcc      780

accacgaaga acatctggag aacatcccag ggaccagtga aaactctgct tttcgtttcc      840

tctttaacct cagcagcatc cctgagaacg aggtgatctc ctctgcagag cttcggctct      900

tccgggagca ggtggaccag ggccctgatt gggaaagggg cttccaccgt ataaacattt      960

atgaggttat gaagccccca gcagaagtgg tgcctgggca cctcatcaca cgactactgg     1020

acacgagact ggtccaccac aatgtgacac ggtgggaaac ttttgatgtg agccctgcgg     1080

tccttcgctg gacccgggag aagcagccaa actatgggct agccattgag gtgactcacc     1140

tccatcagac tcggacccac cagggccagc atgtcaggat tagccgatcg ttacctcaag     1200

ggagtgggaa ttgggcccag ctccggcccc tcctggtcac ctttggccat gatggccggg     1260

gccatgcctt gacccgacgc cggagggcca agcgtagccc taagcatcac tcacagcggg     1320

ccaggaagaa gaataagaac tgccggcgcc actcgctcta tgtggacttc agcgatgtgg     1380

gctggaatga ctggattgtg gccccaccag gctaccaggc cttctactgc catggggact     1440

gcccctttcc actggctgac cacctcaact caaccaacca tgccattgtg cagaccctgg     1500

tcaattctgt caattccagt atccccaaag cctgttgtgt gcccactgaa ctgagtgcca     1560

tctccatgct gtacctggat gagtatgata aggtggtact gaaaaattat caggagatgg     1620

tagtagaggg atgtgggtgc cgctgagatc aggcagtcct tgaggataga cagatataca     1680

caccacacac acacaccaca tacaccacac acacacgttc ccatccactc acccacacac     1740

tacacagact gcttccttat agctggactt ttatttaaaa aaaaaaaaaa aaaaggaaaa     1800

aatccctaaa cattcacctt gaccttattt atgactttac gtgcaaatgt tttgaccata     1860

ttgatcatat attttgacaa aatatattta taactacgta ttaaaagaaa aaaataaaat     1920

gagtcattat tttaaaggta aaaaaaaaaa aaaaaaa                              1957


<210>  155
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Thr Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Thr Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro Ala Ser 
            100                 105                 110         


Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu Asn 
        115                 120                 125             


Ile Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu 
    130                 135                 140                 


Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg Leu 
145                 150                 155                 160 


Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe His 
                165                 170                 175     


Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val Pro 
            180                 185                 190         


Gly His Leu Ile Thr Arg Leu Leu Asp Thr Arg Leu Val His His Asn 
        195                 200                 205             


Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro Ala Val Leu Arg Trp 
    210                 215                 220                 


Thr Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Thr His 
225                 230                 235                 240 


Leu His Gln Thr Arg Thr His Gln Gly Gln His Val Arg Ile Ser Arg 
                245                 250                 255     


Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu Leu 
            260                 265                 270         


Val Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg Arg 
        275                 280                 285             


Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys 
    290                 295                 300                 


Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val 
305                 310                 315                 320 


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr 
                325                 330                 335     


Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
            340                 345                 350         


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile 
        355                 360                 365             


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
    370                 375                 380                 


Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met 
385                 390                 395                 400 


Val Val Glu Gly Cys Gly Cys Arg 
                405             


<210>  156
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  156
uaauaaaacg accaucagca                                                   20


<210>  157
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  157
uaucugucua uccucaagga                                                   20


<210>  158
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  158
uucuuauucu ucuuccuggc                                                   20


<210>  159
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  159
uaauaaaacg accaucagc                                                    19


<210>  160
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  160
ccggtctatc tgtctatcct caagggaccg g                                      31


<210>  161
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  161
ccggtctctc aggtatcaaa ctagcgaccg g                                      31


<210>  162
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  162
ccggtctttg tcaaaatata tgatcgaccg g                                      31


<210>  163
<211>  4049
<212>  DNA
<213>  Homo sapiens

<400>  163
agcgcgtacc actctggcgc tcccgaggcg gcctcttgtg cgatccaggg cgcacaaggc       60

tgggagagcg ccccggggcc cctgctatcc gcgccggagg ttggaagagg gtgggttgcc      120

gccgcccgag ggcgagagcg ccagaggagc gggaagaagg agcgctcgcc cgcccgcctg      180

cctcctcgct gcctccccgg cgttggctct ctggactcct aggcttgctg gctgctcctc      240

ccacccgcgc ccgcctcctc actcgccttt tcgttcgccg gggctgcttt ccaagccctg      300

cggtgcgccc gggcgagtgc ggggcgaggg gcccggggcc agcaccgagc agggggcggg      360

ggtccgggca gagcgcggcc ggccggggag gggccatgtc tggcgcgggc gcagcggggc      420

ccgtctgcag caagtgaccg agcggcgcgg acggccgcct gccccctctg ccacctgggg      480

cggtgcgggc ccggagcccg gagcccgggt agcgcgtaga gccggcgcga tgcacgtgcg      540

ctcactgcga gctgcggcgc cgcacagctt cgtggcgctc tgggcacccc tgttcctgct      600

gcgctccgcc ctggccgact tcagcctgga caacgaggtg cactcgagct tcatccaccg      660

gcgcctccgc agccaggagc ggcgggagat gcagcgcgag atcctctcca ttttgggctt      720

gccccaccgc ccgcgcccgc acctccaggg caagcacaac tcggcaccca tgttcatgct      780

ggacctgtac aacgccatgg cggtggagga gggcggcggg cccggcggcc agggcttctc      840

ctacccctac aaggccgtct tcagtaccca gggcccccct ctggccagcc tgcaagatag      900

ccatttcctc accgacgccg acatggtcat gagcttcgtc aacctcgtgg aacatgacaa      960

ggaattcttc cacccacgct accaccatcg agagttccgg tttgatcttt ccaagatccc     1020

agaaggggaa gctgtcacgg cagccgaatt ccggatctac aaggactaca tccgggaacg     1080

cttcgacaat gagacgttcc ggatcagcgt ttatcaggtg ctccaggagc acttgggcag     1140

ggaatcggat ctcttcctgc tcgacagccg taccctctgg gcctcggagg agggctggct     1200

ggtgtttgac atcacagcca ccagcaacca ctgggtggtc aatccgcggc acaacctggg     1260

cctgcagctc tcggtggaga cgctggatgg gcagagcatc aaccccaagt tggcgggcct     1320

gattgggcgg cacgggcccc agaacaagca gcccttcatg gtggctttct tcaaggccac     1380

ggaggtccac ttccgcagca tccggtccac ggggagcaaa cagcgcagcc agaaccgctc     1440

caagacgccc aagaaccagg aagccctgcg gatggccaac gtggcagaga acagcagcag     1500

cgaccagagg caggcctgta agaagcacga gctgtatgtc agcttccgag acctgggctg     1560

gcaggactgg atcatcgcgc ctgaaggcta cgccgcctac tactgtgagg gggagtgtgc     1620

cttccctctg aactcctaca tgaacgccac caaccacgcc atcgtgcaga cgctggtcca     1680

cttcatcaac ccggaaacgg tgcccaagcc ctgctgtgcg cccacgcagc tcaatgccat     1740

ctccgtcctc tacttcgatg acagctccaa cgtcatcctg aagaaataca gaaacatggt     1800

ggtccgggcc tgtggctgcc actagctcct ccgagaattc agaccctttg gggccaagtt     1860

tttctggatc ctccattgct cgccttggcc aggaaccagc agaccaactg ccttttgtga     1920

gaccttcccc tccctatccc caactttaaa ggtgtgagag tattaggaaa catgagcagc     1980

atatggcttt tgatcagttt ttcagtggca gcatccaatg aacaagatcc tacaagctgt     2040

gcaggcaaaa cctagcagga aaaaaaaaca acgcataaag aaaaatggcc gggccaggtc     2100

attggctggg aagtctcagc catgcacgga ctcgtttcca gaggtaatta tgagcgccta     2160

ccagccaggc cacccagccg tgggaggaag ggggcgtggc aaggggtggg cacattggtg     2220

tctgtgcgaa aggaaaattg acccggaagt tcctgtaata aatgtcacaa taaaacgaat     2280

gaatgaaaat ggttaggacg ttacagatat attttcctaa acaatttatc cccatttctc     2340

ggtttatcct gatgcgtaaa cagaagctgt gtcaagtgga gggcggggag gtccctctcc     2400

attccctaca gttttcatcc tgaggcttgc agaggcccag tgtttaccga ggtttgccca     2460

aatccaagat ctagtgggag gggaaagagc aaatgtctgc tccgaggagg gcggtgtgtt     2520

gatctttgga ggaaaaatat gttctgttgt tcagctggat ttgccgtggc agaaatgaaa     2580

ctaggtgtgt gaaatacccg cagacatttg ggattggctt ttcacctcgc cccagtggta     2640

gtaaatccat gtgaaattgc agaggggaca aggacagcaa gtaggatgga acttgcaact     2700

caaccctgtt gttaagaagc accaatgggc cgggcacagt agctcccacc tgtaatccca     2760

gcactttggg aggctgaggt gggcggatca tttgaggtca ggagttcgag accagcctgg     2820

ccaacatggt gaaaccccat ctctactaaa aatacaaaaa ttagccgggc atggtggcac     2880

gcacctgtaa tcccagctac tctggaggct gaggcaggag aattgcttga accccagagg     2940

tggaggttgc agtgagccaa gatcgtccca ctgcactcca gcttgggtga caaaacaaga     3000

ctccatctca aaagaaaaaa aaaacagcac caatgaagcc tagttctcca cgggagtggg     3060

gtgagcagga gcactgcaca tcgccccagt ggaccctctg gtctttgtct gcagtggcat     3120

tccaaggctg ggccctggca agggcacccg tggctgtctc ttcatttgca gaccctgatc     3180

agaagtctct gcaaacaaat ttgctccttg aattaagggg gagatggcat aataggaggt     3240

ctgatgggtg caggatgtgc tggacttaca ttgcaaatag aagccttgtt gagggtgaca     3300

tcctaaccaa gtgtcccgat ttggaggtgg catttctgac gtggctcttg gtgtaagcct     3360

gccttgcctt ggctggtgag tcccataaat agtatgcact cagcctccgg ccacaaacac     3420

aaggcctagg ggagggctag actgtctgca aacgttttct gcatctgtaa agaaaacaag     3480

gtgatcgaaa actgtggcca tgtggaaccc ggtcttgtgg gggactgttt ctccatcttg     3540

actcagacag ttcctggaaa caccggggct ctgtttttat tttctttgat gtttttcttc     3600

tttagtagct tgggctgcag cctccactct ctagtcactg gggaggagta ttttttgtta     3660

tgtttggttt catttgctgg cagagctggg gctttttgtg tgatccctct tggtgtgagt     3720

tttctgaccc aaccagcctc tggttagcat catttgtaca tttaaacctg taaatagttg     3780

ttacaaagca aagagattat ttatttccat ccaaagctct tttgaacacc cccccccctt     3840

taatccctcg ttcaggacga tgagcttgct ttccttcaac ctgtttgttt tcttatttaa     3900

gactatttat taatggttgg accaatgtac tcacagctgt tgcgtcgagc agtccttagt     3960

gaaaattctg tataaataga caaaatgaaa agggtttgac cttgcaataa aaggagacgt     4020

ttggttctgg caaaaaaaaa aaaaaaaaa                                       4049


<210>  164
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  164

Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      


Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala Asp Phe Ser 
            20                  25                  30          


Leu Asp Asn Glu Val His Ser Ser Phe Ile His Arg Arg Leu Arg Ser 
        35                  40                  45              


Gln Glu Arg Arg Glu Met Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu 
    50                  55                  60                  


Pro His Arg Pro Arg Pro His Leu Gln Gly Lys His Asn Ser Ala Pro 
65                  70                  75                  80  


Met Phe Met Leu Asp Leu Tyr Asn Ala Met Ala Val Glu Glu Gly Gly 
                85                  90                  95      


Gly Pro Gly Gly Gln Gly Phe Ser Tyr Pro Tyr Lys Ala Val Phe Ser 
            100                 105                 110         


Thr Gln Gly Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Thr 
        115                 120                 125             


Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys 
    130                 135                 140                 


Glu Phe Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu 
145                 150                 155                 160 


Ser Lys Ile Pro Glu Gly Glu Ala Val Thr Ala Ala Glu Phe Arg Ile 
                165                 170                 175     


Tyr Lys Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Thr Phe Arg Ile 
            180                 185                 190         


Ser Val Tyr Gln Val Leu Gln Glu His Leu Gly Arg Glu Ser Asp Leu 
        195                 200                 205             


Phe Leu Leu Asp Ser Arg Thr Leu Trp Ala Ser Glu Glu Gly Trp Leu 
    210                 215                 220                 


Val Phe Asp Ile Thr Ala Thr Ser Asn His Trp Val Val Asn Pro Arg 
225                 230                 235                 240 


His Asn Leu Gly Leu Gln Leu Ser Val Glu Thr Leu Asp Gly Gln Ser 
                245                 250                 255     


Ile Asn Pro Lys Leu Ala Gly Leu Ile Gly Arg His Gly Pro Gln Asn 
            260                 265                 270         


Lys Gln Pro Phe Met Val Ala Phe Phe Lys Ala Thr Glu Val His Phe 
        275                 280                 285             


Arg Ser Ile Arg Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser 
    290                 295                 300                 


Lys Thr Pro Lys Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu 
305                 310                 315                 320 


Asn Ser Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr 
                325                 330                 335     


Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu 
            340                 345                 350         


Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn 
        355                 360                 365             


Ser Tyr Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His 
    370                 375                 380                 


Phe Ile Asn Pro Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln 
385                 390                 395                 400 


Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile 
                405                 410                 415     


Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
            420                 425                 430     


<210>  165
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  165
uuccuaauac ucucacacc                                                    19


<210>  166
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  166
uaacaaaaaa uacuccucc                                                    19


<210>  167
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  167
uaaauaagaa aacaaacagg                                                   20


<210>  168
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  168
uuccuaauac ucucacaccu                                                   20


<210>  169
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  169
ccggtctaac aaaaaatact cctcccgacc gg                                     32


<210>  170
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  170
ccggtcttgt aacaacuatt tacagggacc gg                                     32


<210>  171
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemcially synthesized

<400>  171
ccggtctaaa taagaaaaca aacaggaccg g                                      31


<210>  172
<211>  1802
<212>  DNA
<213>  Homo sapiens

<400>  172
gggcagctcc accctgggag ggactgtggc ccaggtactg cccgggtgct actttatggg       60

cagcagctca gttgagttag agtctggaag acctcagaag acctcctgtc ctatgaggcc      120

ctccccatgg ctttagagac gatctgccga ccctctggga gaaaatccag caagatgcaa      180

gccttcagaa tctgggatgt taaccagaag accttctatc tgaggaacaa ccaactagtt      240

gctggatact tgcaaggacc aaatgtcaat ttagaagaaa agatagatgt ggtacccatt      300

gagcctcatg ctctgttctt gggaatccat ggagggaaga tgtgcctgtc ctgtgtcaag      360

tctggtgatg agaccagact ccagctggag gcagttaaca tcactgacct gagcgagaac      420

agaaagcagg acaagcgctt cgccttcatc cgctcagaca gtggccccac caccagtttt      480

gagtctgccg cctgccccgg ttggttcctc tgcacagcga tggaagctga ccagcccgtc      540

agcctcacca atatgcctga cgaaggcgtc atggtcacca aattctactt ccaggaggac      600

gagtagtact gcccaggcct gcctgttccc attcttgcat ggcaaggact gcagggactg      660

ccagtccccc tgccccaggg ctcccggcta tgggggcact gaggaccagc cattgagggg      720

tggaccctca gaaggcgtca caacaacctg gtcacaggac tctgcctcct cttcaactga      780

ccagcctcca tgctgcctcc agaatggtct ttctaatgtg tgaatcagag cacagcagcc      840

cctgcacaaa gcccttccat gtcgcctctg cattcaggat caaaccccga ccacctgccc      900

aacctgctct cctcttgcca ctgcctcttc ctccctcatt ccaccttccc atgccctgga      960

tccatcaggc cacttgatga cccccaacca agtggctccc acaccctgtt ttacaaaaaa     1020

gaaaagacca gtccatgagg gaggttttta agggtttgtg gaaaatgaaa attaggattt     1080

catgattttt ttttttcagt ccccgtgaag gagagccctt catttggaga ttatgttctt     1140

tcggggagag gctgaggact taaaatattc ctgcatttgt gaaatgatgg tgaaagtaag     1200

tggtagcttt tcccttcttt ttcttctttt tttgtgatgt cccaacttgt aaaaattaaa     1260

agttatggta ctatgttagc cccataattt tttttttcct tttaaaacac ttccataatc     1320

tggactcctc tgtccaggca ctgctgccca gcctccaagc tccatctcca ctccagattt     1380

tttacagctg cctgcagtac tttacctcct atcagaagtt tctcagctcc caaggctctg     1440

agcaaatgtg gctcctgggg gttctttctt cctctgctga aggaataaat tgctccttga     1500

cattgtagag cttctggcac ttggagactt gtatgaaaga tggctgtgcc tctgcctgtc     1560

tcccccaccg ggctgggagc tctgcagagc aggaaacatg actcgtatat gtctcaggtc     1620

cctgcagggc caagcaccta gcctcgctct tggcaggtac tcagcgaatg aatgctgtat     1680

atgttgggtg caaagttccc tacttcctgt gacttcagct ctgttttaca ataaaatctt     1740

gaaaatgcct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1800

aa                                                                    1802


<210>  173
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
    130                 135                 140                 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 155                 


<210>  174
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  174
ugugucucuc ucuguguccu gccagugguu uuacccuaug guagguuacg ucaugcuguu       60

cuaccacagg guagaaccac ggacaggaua ccggggcacc                            100


<210>  175
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  175
cagugguuuu acccuauggu ag                                                22


<210>  176
<211>  87
<212>  DNA
<213>  Homo sapiens

<400>  176
accgcaggga aaaugaggga cuuuuggggg cagauguguu uccauuccac uaucauaaug       60

ccccuaaaaa uccuuauugc ucuugca                                           87


<210>  177
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  177
agggacuuuu gggggcagau gug                                               23


<210>  178
<211>  86
<212>  DNA
<213>  Homo sapiens

<400>  178
ugccagucuc uaggucccug agacccuuua accugugagg acauccaggg ucacagguga       60

gguucuuggg agccuggcgu cuggcc                                            86


<210>  179
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  179
ucccugagac ccuuuaaccu guga                                              24


<210>  180
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  180
acaggugagg uucuugggag cc                                                22


<210>  181
<211>  1968
<212>  DNA
<213>  Homo sapiens

<400>  181
actccgggtg gcaggcgccc gggggaatcc cagctgactc gctcactgcc ttcgaagtcc       60

ggcgcccccc gggagggaac tgggtggccg caccctcccg gctgcggtgg ctgtcgcccc      120

ccaccctgca gccaggactc gatggaggta cagagctcgg cttctttgcc ttgggagggg      180

agtggtggtg gttgaaaggg cgatggaatt ttccccgaaa gcctacgccc agggcccctc      240

ccagctccag cgttaccctc cggtctatcc tactggccga gctgccccgc cttctcatgg      300

ggaaaactta gccgcaactt caatttttgg tttttccttt aatgacactt ctgaggctct      360

cctagccatc ctcccgcttc cggaggagcg cagatcgcag gtccctttgc ccctggcgtg      420

cgactcccta ctgcgctgcg ctcttacggc gttccaggct gctggctagc gcaaggcggg      480

ccgggcaccc cgcgctccgc tgggagggtg agggacgcgc gtctggcggc cccagccaag      540

ctgcgggttt ctgagaagac gctgtcccgc agccctgagg gctgagttct gcacccagtc      600

aagctcagga aggccaagaa aagaatccat tccaatatat ggccatgtgg ctctttggag      660

caatgttcca tcatgttcca tgctgctgac gtcacatgga gcacagaaat caatgttagc      720

agatagccag cccatacaag atcgtattgt attgtaggag gcatcgtgga tggatggctg      780

ctggaaaccc cttgccatag ccagctcttc ttcaatactt aaggatttac cgtggctttg      840

agtaatgaga atttcgaaac cacatttgag aagtatttcc atccagtgct acttgtgttt      900

acttctaaac agtcattttc taactgaagc tggcattcat gtcttcattt tgggctgttt      960

cagtgcaggg cttcctaaaa cagaagccaa ctgggtgaat gtaataagtg atttgaaaaa     1020

aattgaagat cttattcaat ctatgcatat tgatgctact ttatatacgg aaagtgatgt     1080

tcaccccagt tgcaaagtaa cagcaatgaa gtgctttctc ttggagttac aagttatttc     1140

acttgagtcc ggagatgcaa gtattcatga tacagtagaa aatctgatca tcctagcaaa     1200

caacagtttg tcttctaatg ggaatgtaac agaatctgga tgcaaagaat gtgaggaact     1260

ggaggaaaaa aatattaaag aatttttgca gagttttgta catattgtcc aaatgttcat     1320

caacacttct tgattgcaat tgattctttt taaagtgttt ctgttattaa caaacatcac     1380

tctgctgctt agacataaca aaacactcgg catttcaaat gtgctgtcaa aacaagtttt     1440

tctgtcaaga agatgatcag accttggatc agatgaactc ttagaaatga aggcagaaaa     1500

atgtcattga gtaatatagt gactatgaac ttctctcaga cttactttac tcattttttt     1560

aatttattat tgaaattgta catatttgtg gaataatgta aaatgttgaa taaaaatatg     1620

tacaagtgtt gttttttaag ttgcactgat attttacctc ttattgcaaa atagcatttg     1680

tttaagggtg atagtcaaat tatgtattgg tggggctggg taccaatgct gcaggtcaac     1740

agctatgctg gtaggctcct gcctgtgtgg aaccactgac tactggctct cattgacttc     1800

cttactaagc atagcaaaca gaggaagaat ttgttatcag taagaaaaag aagaactata     1860

tgtgaatcct cttctttaca ctgtaattta gttattgatg tataaagcaa ctgttatgaa     1920

ataaagaaat tgcaataact ggcaaaaaaa aaaaaaaaaa aaaaaaaa                  1968


<210>  182
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  183
<211>  1252
<212>  DNA
<213>  Homo sapiens

<400>  183
ctttgaattc ctagctcctg tggtctccag atttcaggcc taagatgaaa gcctctagtc       60

ttgccttcag ccttctctct gctgcgtttt atctcctatg gactccttcc actggactga      120

agacactcaa tttgggaagc tgtgtgatcg ccacaaacct tcaggaaata cgaaatggat      180

tttctgagat acggggcagt gtgcaagcca aagatggaaa cattgacatc agaatcttaa      240

ggaggactga gtctttgcaa gacacaaagc ctgcgaatcg atgctgcctc ctgcgccatt      300

tgctaagact ctatctggac agggtattta aaaactacca gacccctgac cattatactc      360

tccggaagat cagcagcctc gccaattcct ttcttaccat caagaaggac ctccggctct      420

gtcatgccca catgacatgc cattgtgggg aggaagcaat gaagaaatac agccagattc      480

tgagtcactt tgaaaagctg gaacctcagg cagcagttgt gaaggctttg ggggaactag      540

acattcttct gcaatggatg gaggagacag aataggagga aagtgatgct gctgctaaga      600

atattcgagg tcaagagctc cagtcttcaa tacctgcaga ggaggcatga ccccaaacca      660

ccatctcttt actgtactag tcttgtgctg gtcacagtgt atcttattta tgcattactt      720

gcttccttgc atgattgtct ttatgcatcc ccaatcttaa ttgagaccat acttgtataa      780

gatttttgta atatctttct gctattggat atatttatta gttaatatat ttatttattt      840

tttgctattt aatgtattta tttttttact tggacatgaa actttaaaaa aattcacaga      900

ttatatttat aacctgacta gagcaggtga tgtattttta tacagtaaaa aaaaaaaacc      960

ttgtaaattc tagaagagtg gctagggggg ttattcattt gtattcaact aaggacatat     1020

ttactcatgc tgatgctctg tgagatattt gaaattgaac caatgactac ttaggatggg     1080

ttgtggaata agttttgatg tggaattgca catctacctt acaattactg accatcccca     1140

gtagactccc cagtcccata attgtgtatc ttccagccag gaatcctaca cggccagcat     1200

gtatttctac aaataaagtt ttctttgcat aacaaaaaaa aaaaaaaaaa aa             1252


<210>  184
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Lys Ala Ser Ser Leu Ala Phe Ser Leu Leu Ser Ala Ala Phe Tyr 
1               5                   10                  15      


Leu Leu Trp Thr Pro Ser Thr Gly Leu Lys Thr Leu Asn Leu Gly Ser 
            20                  25                  30          


Cys Val Ile Ala Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu 
        35                  40                  45              


Ile Arg Gly Ser Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile 
    50                  55                  60                  


Leu Arg Arg Thr Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys 
65                  70                  75                  80  


Cys Leu Leu Arg His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys 
                85                  90                  95      


Asn Tyr Gln Thr Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu 
            100                 105                 110         


Ala Asn Ser Phe Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala 
        115                 120                 125             


His Met Thr Cys His Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln 
    130                 135                 140                 


Ile Leu Ser His Phe Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys 
145                 150                 155                 160 


Ala Leu Gly Glu Leu Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
                165                 170                 175     


<210>  185
<211>  2265
<212>  DNA
<213>  Homo sapiens

<400>  185
acagccagag ggacgagcta gcccgacgat ggcccagggg acattgatcc gtgtgacccc       60

agagcagccc acccatgccg tgtgtgtgct gggcaccttg actcagcttg acatctgcag      120

ctctgcccct gaggactgca cgtccttcag catcaacgcc tccccagggg tggtcgtgga      180

tattgcccac ggccctccag ccaagaagaa atccacaggt tcctccacat ggcccctgga      240

ccctggggta gaggtgaccc tgacgatgaa agtggccagt ggtagcacag gcgaccagaa      300

ggttcagatt tcatactacg gacccaagac tccaccagtc aaagctctac tctacctcac      360

cggggtggaa atctccttgt gcgcagacat cacccgcacc ggcaaagtga agccaaccag      420

agctgtgaaa gatcagagga cctggacctg gggcccttgt ggacagggtg ccatcctgct      480

ggtgaactgt gacagagaca atctcgaatc ttctgccatg gactgcgagg atgatgaagt      540

gcttgacagc gaagacctgc aggacatgtc gctgatgacc ctgagcacga agacccccaa      600

ggacttcttc acaaaccata cactggtgct ccacgtggcc aggtctgaga tggacaaagt      660

gagggtgttt caggccacac ggggcaaact gtcctccaag tgcagcgtag tcttgggtcc      720

caagtggccc tctcactacc tgatggtccc cggtggaaag cacaacatgg acttctacgt      780

ggaggccctc gctttcccgg acaccgactt cccggggctc attaccctca ccatctccct      840

gctggacacg tccaacctgg agctccccga ggctgtggtg ttccaagaca gcgtggtctt      900

ccgcgtggcg ccctggatca tgacccccaa cacccagccc ccgcaggagg tgtacgcgtg      960

cagtattttt gaaaatgagg acttcctgaa gtcagtgact actctggcca tgaaagccaa     1020

gtgcaagctg accatctgcc ctgaggagga gaacatggat gaccagtgga tgcaggatga     1080

aatggagatc ggctacatcc aagccccaca caaaacgctg cccgtggtct tcgactctcc     1140

aaggaacaga ggcctgaagg agtttcccat caaacgcgtg atgggtccag attttggcta     1200

tgtaactcga gggccccaaa cagggggtat cagtggactg gactcctttg ggaacctgga     1260

agtgagcccc ccagtcacag tcaggggcaa ggaatacccg ctgggcagga ttctcttcgg     1320

ggacagctgt tatcccagca atgacagccg gcagatgcac caggccctgc aggacttcct     1380

cagtgcccag caggtgcagg cccctgtgaa gctctattct gactggctgt ccgtgggcca     1440

cgtggacgag ttcctgagct ttgtgccagc acccgacagg aagggcttcc ggctgctcct     1500

ggccagcccc aggtcctgct acaaactgtt ccaggagcag cagaatgagg gccacgggga     1560

ggccctgctg ttcgaaggga tcaagaaaaa aaaacagcag aaaataaaga acattctgtc     1620

aaacaagaca ttgagagaac ataattcatt tgtggagaga tgcatcgact ggaaccgcga     1680

gctgctgaag cgggagctgg gcctggccga gagtgacatc attgacatcc cgcagctctt     1740

caagctcaaa gagttctcta aggcggaagc ttttttcccc aacatggtga acatgctggt     1800

gctagggaag cacctgggca tccccaagcc cttcgggccc gtcatcaacg gccgctgctg     1860

cctggaggag aaggtgtgtt ccctgctgga gccactgggc ctccagtgca ccttcatcaa     1920

cgacttcttc acctaccaca tcaggcatgg ggaggtgcac tgcggcacca acgtgcgcag     1980

aaagcccttc tccttcaagt ggtggaacat ggtgccctga gcccatcttc cctggcgtcc     2040

tctccctcct ggccagatgt cgctgggtcc tctgcagtgt ggcaagcaag agctcttgtg     2100

aatattgtgg ctccctgggg gcggccagcc ctcccagcag tggcttgctt tcttctcctg     2160

tgatgtccca gtttcccact ctgaagatcc caacatggtc ctagcactgc acactcagtt     2220

ctgctctaag aagctgcaat aaagtttttt taagtcactt tgtac                     2265


<210>  186
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Gly Pro Asp Phe Gly Tyr Val Thr Arg Gly Pro Gln Thr Gly Gly 
385                 390                 395                 400 


Ile Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Thr Val Arg Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Phe Gly Asp 
            420                 425                 430         


Ser Cys Tyr Pro Ser Asn Asp Ser Arg Gln Met His Gln Ala Leu Gln 
        435                 440                 445             


Asp Phe Leu Ser Ala Gln Gln Val Gln Ala Pro Val Lys Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro 
465                 470                 475                 480 


Ala Pro Asp Arg Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro Arg Ser 
                485                 490                 495     


Cys Tyr Lys Leu Phe Gln Glu Gln Gln Asn Glu Gly His Gly Glu Ala 
            500                 505                 510         


Leu Leu Phe Glu Gly Ile Lys Lys Lys Lys Gln Gln Lys Ile Lys Asn 
        515                 520                 525             


Ile Leu Ser Asn Lys Thr Leu Arg Glu His Asn Ser Phe Val Glu Arg 
    530                 535                 540                 


Cys Ile Asp Trp Asn Arg Glu Leu Leu Lys Arg Glu Leu Gly Leu Ala 
545                 550                 555                 560 


Glu Ser Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Leu Lys Glu Phe 
                565                 570                 575     


Ser Lys Ala Glu Ala Phe Phe Pro Asn Met Val Asn Met Leu Val Leu 
            580                 585                 590         


Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Val Ile Asn Gly 
        595                 600                 605             


Arg Cys Cys Leu Glu Glu Lys Val Cys Ser Leu Leu Glu Pro Leu Gly 
    610                 615                 620                 


Leu Gln Cys Thr Phe Ile Asn Asp Phe Phe Thr Tyr His Ile Arg His 
625                 630                 635                 640 


Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Ser Phe 
                645                 650                 655     


Lys Trp Trp Asn Met Val Pro 
            660             


<210>  187
<211>  801
<212>  DNA
<213>  Homo sapiens

<400>  187
atggtgtgtc tgaggctccc tggaggctcc tgcatggcag ttctgacagt gacactgatg       60

gtgctgagct ccccactggc tttggctggg gacaccagac cacgtttctt ggaggaggtt      120

aagtttgagt gtcatttctt caacgggacg gagcgggtgc ggttgctgga aagacgcgtc      180

cataaccaag aggagtacgc gcgctacgac agcgacgtgg gggagtaccg ggcggtgacg      240

gagctggggc ggcctgatgc cgagtactgg aacagccaga aggacctcct ggagcggagg      300

cgtgccgcgg tggacaccta ctgcagacac aactacgggg ttggtgagag cttcacagtg      360

cagcggcgag ttcaacctaa ggtgactgtg tatccttcaa agacccagcc cctgcagcac      420

cacaacctcc tggtctgttc tgtgaatggt ttctatccag gcagcattga agtcaggtgg      480

ttccggaacg gccaggaaga gaagactggg gtggtgtcca cgggcctgat ccagaatgga      540

gactggacct tccagaccct ggtgatgctg gaaacagttc ctcagagtgg agaggtttac      600

acctgccaag tggagcaccc aagtgtgatg agccctctca cagtggaatg gagagcacgg      660

tctgaatctg cacagagcaa gatgctgagt ggagtcgggg gctttgtgct gggcctgctc      720

ttccttgggg ccgggctgtt catctacttc aggaatcaga aaggacactc tggacttccg      780

ccaacaggat tcctgagctg a                                                801


<210>  188
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Glu Val Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Arg Val His Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Ala Arg Tyr Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Gln Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Met Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Pro Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  189
<211>  3436
<212>  DNA
<213>  Homo sapiens

<400>  189
ggtgtctcgg ccatgacaca catttgacat gccctccctc aacctactta tagactattt       60

ttcttgctct gcagcatgga ccaaagagaa attctgcaga agttcctgga tgaggcccaa      120

agcaagaaaa ttactaaaga ggagtttgcc aatgaatttc tgaagctgaa aaggcaatct      180

accaagtaca aggcagacaa aacctatcct acaactgtgg ctgagaagcc caagaatatc      240

aagaaaaaca gatataagga tattttgccc tatgattata gccgggtaga actatccctg      300

ataacctctg atgaggattc cagctacatc aatgccaact tcattaaggg agtttatgga      360

cccaaggctt atattgccac ccagggtcct ttatctacaa ccctcctgga cttctggagg      420

atgatttggg aatatagtgt ccttatcatt gttatggcat gcatggagta tgaaatggga      480

aagaaaaagt gtgagcgcta ctgggctgag ccaggagaga tgcagctgga atttggccct      540

ttctctgtat cctgtgaagc tgaaaaaagg aaatctgatt atataatcag gactctaaaa      600

gttaagttca atagtgaaac tcgaactatc taccagtttc attacaagaa ttggccagac      660

catgatgtac cttcatctat agaccctatt cttgagctca tctgggatgt acgttgttac      720

caagaggatg acagtgttcc catatgcatt cactgcagtg ctggctgtgg aaggactggt      780

gttatttgtg ctattgatta tacatggatg ttgctaaaag atgggagtca agcaaagcat      840

tgtattcctg agaaaaatca cactctccaa gcagactctt attctcctaa tttaccaaaa      900

agtaccacaa aagcagcaaa aatgatgaac caacaaagga caaaaatgga aatcaaagaa      960

tcttcttcct ttgactttag gacttctgaa ataagtgcaa aagaagagct agttttgcac     1020

cctgctaaat caagcacttc ttttgacttt ctggagctaa attacagttt tgacaaaaat     1080

gctgacacaa ccatgaaatg gcagacaaag gcatttccaa tagttgggga gcctcttcag     1140

aagcatcaaa gtttggattt gggctctctt ttgtttgagg gatgttctaa ttctaaacct     1200

gtaaatgcag caggaagata ttttaattca aaggtgccaa taacacggac caaatcaact     1260

ccttttgaat tgatacagca gagagaaacc aaggaggtgg acagcaagga aaacttttct     1320

tatttggaat ctcaaccaca tgattcttgt tttgtagaga tgcaggctca aaaagtaatg     1380

catgtttctt cagcagaact gaattattca ctgccatatg actctaaaca ccaaatacgt     1440

aatgcctcta atgtaaagca ccatgactct agtgctcttg gtgtatattc ttacatacct     1500

ttagtggaaa atccttattt ttcatcatgg cctccaagtg gtaccagttc taagatgtct     1560

cttgatttac ctgagaagca agatggaact gtttttcctt cttctctgtt gccaacatcc     1620

tctacatccc tcttctctta ttacaattca catgattctt tatcactgaa ttctccaacc     1680

aatatttcct cactattgaa ccaggagtca gctgtactag caactgctcc aaggatagat     1740

gatgaaatcc cccctccact tcctgtacgg acacctgaat catttattgt ggttgaggaa     1800

gctggagaat tctcaccaaa tgttcccaaa tccttatcct cagctgtgaa ggtaaaaatt     1860

ggaacatcac tggaatgggg tggaacatct gaaccaaaga aatttgatga ctctgtgata     1920

cttagaccaa gcaagagtgt aaaactccga agtcctaaat cagaactaca tcaagatcgt     1980

tcttctcccc cacctcctct cccagaaaga actctagagt ccttctttct tgccgatgaa     2040

gattgtatgc aggcccaatc tatagaaaca tattctacta gctatcctga caccatggaa     2100

aattcaacat cttcaaaaca gacactgaag actcctggaa aaagtttcac aaggagtaag     2160

agtttgaaaa ttttgcgaaa catgaaaaag agtatctgta attcttgccc accaaacaag     2220

cctgcagaat ctgttcagtc aaataactcc agctcatttc tgaattttgg ttttgcaaac     2280

cgtttttcaa aacccaaagg accaaggaat ccaccaccaa cttggaatat ttaataaaac     2340

tccagattta taataatatg ggctgcaagt acacctgcaa ataaaactac tagaatactg     2400

ctagttaaaa taagtgctct atatgcataa tatcaaatat gaagatatgc taatgtgtta     2460

atagctttta aaagaaaagc aaaatgccaa taagtgccag ttttgcattt tcatatcatt     2520

tgcattgagt tgaaaactgc aaataaaagt ttgtcacttg agcttatgta cagaatgcta     2580

tatgagaaac acttttagaa tggatttatt tttcattttt gccagttatt tttattttct     2640

tttacttttt tacataaaca taaacttcaa aaggtttgta agatttggat ctcaactaat     2700

ttctacattg ccagaatata ctataaaaag ttaaaaaaaa aacttacttt gtgggttgca     2760

atacaaactg ctcttgacaa tgactattcc ctgacagtta tttttgccta aatggagtat     2820

accttgtaaa tcttcccaaa tgttgtggaa aactggaata ttaagaaaat gagaaattat     2880

atttattaga ataaaatgtg caaataatga caattatttg aatgtaacaa ggaattcaac     2940

tgaaatcctg ataagtttta accaaagtca ttaaattacc aattctagaa aagtaatcaa     3000

tgaaatataa tagctatctt ttggtagcaa aagatataaa ttgtatatgt ttatacagga     3060

tctttcagat catgtgcaat ttttatctaa ccaatcagaa atactagttt aaaatgaatt     3120

tctatatgaa tatggatctg ccataagaaa atctagttca actctaattt tatgtagtaa     3180

ataaattggc aggtaattgt ttttacaaag aatccacctg acttccccta atgcattaaa     3240

aatattttta tttaaataac tttatttata acttttagaa acatgtagta ttgtttaaac     3300

atcatttgtt cttcagtatt tttcatttgg aagtccaata gggcaaattg aatgaagtat     3360

tattatctgt ctcttgtagt acaatgtatc caacagacac tcaataaact ttttggttgt     3420

taaaaaaaaa aaaaaa                                                     3436


<210>  190
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Asp Gln Arg Glu Ile Leu Gln Lys Phe Leu Asp Glu Ala Gln Ser 
1               5                   10                  15      


Lys Lys Ile Thr Lys Glu Glu Phe Ala Asn Glu Phe Leu Lys Leu Lys 
            20                  25                  30          


Arg Gln Ser Thr Lys Tyr Lys Ala Asp Lys Thr Tyr Pro Thr Thr Val 
        35                  40                  45              


Ala Glu Lys Pro Lys Asn Ile Lys Lys Asn Arg Tyr Lys Asp Ile Leu 
    50                  55                  60                  


Pro Tyr Asp Tyr Ser Arg Val Glu Leu Ser Leu Ile Thr Ser Asp Glu 
65                  70                  75                  80  


Asp Ser Ser Tyr Ile Asn Ala Asn Phe Ile Lys Gly Val Tyr Gly Pro 
                85                  90                  95      


Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ser Thr Thr Leu Leu Asp 
            100                 105                 110         


Phe Trp Arg Met Ile Trp Glu Tyr Ser Val Leu Ile Ile Val Met Ala 
        115                 120                 125             


Cys Met Glu Tyr Glu Met Gly Lys Lys Lys Cys Glu Arg Tyr Trp Ala 
    130                 135                 140                 


Glu Pro Gly Glu Met Gln Leu Glu Phe Gly Pro Phe Ser Val Ser Cys 
145                 150                 155                 160 


Glu Ala Glu Lys Arg Lys Ser Asp Tyr Ile Ile Arg Thr Leu Lys Val 
                165                 170                 175     


Lys Phe Asn Ser Glu Thr Arg Thr Ile Tyr Gln Phe His Tyr Lys Asn 
            180                 185                 190         


Trp Pro Asp His Asp Val Pro Ser Ser Ile Asp Pro Ile Leu Glu Leu 
        195                 200                 205             


Ile Trp Asp Val Arg Cys Tyr Gln Glu Asp Asp Ser Val Pro Ile Cys 
    210                 215                 220                 


Ile His Cys Ser Ala Gly Cys Gly Arg Thr Gly Val Ile Cys Ala Ile 
225                 230                 235                 240 


Asp Tyr Thr Trp Met Leu Leu Lys Asp Gly Ser Gln Ala Lys His Cys 
                245                 250                 255     


Ile Pro Glu Lys Asn His Thr Leu Gln Ala Asp Ser Tyr Ser Pro Asn 
            260                 265                 270         


Leu Pro Lys Ser Thr Thr Lys Ala Ala Lys Met Met Asn Gln Gln Arg 
        275                 280                 285             


Thr Lys Met Glu Ile Lys Glu Ser Ser Ser Phe Asp Phe Arg Thr Ser 
    290                 295                 300                 


Glu Ile Ser Ala Lys Glu Glu Leu Val Leu His Pro Ala Lys Ser Ser 
305                 310                 315                 320 


Thr Ser Phe Asp Phe Leu Glu Leu Asn Tyr Ser Phe Asp Lys Asn Ala 
                325                 330                 335     


Asp Thr Thr Met Lys Trp Gln Thr Lys Ala Phe Pro Ile Val Gly Glu 
            340                 345                 350         


Pro Leu Gln Lys His Gln Ser Leu Asp Leu Gly Ser Leu Leu Phe Glu 
        355                 360                 365             


Gly Cys Ser Asn Ser Lys Pro Val Asn Ala Ala Gly Arg Tyr Phe Asn 
    370                 375                 380                 


Ser Lys Val Pro Ile Thr Arg Thr Lys Ser Thr Pro Phe Glu Leu Ile 
385                 390                 395                 400 


Gln Gln Arg Glu Thr Lys Glu Val Asp Ser Lys Glu Asn Phe Ser Tyr 
                405                 410                 415     


Leu Glu Ser Gln Pro His Asp Ser Cys Phe Val Glu Met Gln Ala Gln 
            420                 425                 430         


Lys Val Met His Val Ser Ser Ala Glu Leu Asn Tyr Ser Leu Pro Tyr 
        435                 440                 445             


Asp Ser Lys His Gln Ile Arg Asn Ala Ser Asn Val Lys His His Asp 
    450                 455                 460                 


Ser Ser Ala Leu Gly Val Tyr Ser Tyr Ile Pro Leu Val Glu Asn Pro 
465                 470                 475                 480 


Tyr Phe Ser Ser Trp Pro Pro Ser Gly Thr Ser Ser Lys Met Ser Leu 
                485                 490                 495     


Asp Leu Pro Glu Lys Gln Asp Gly Thr Val Phe Pro Ser Ser Leu Leu 
            500                 505                 510         


Pro Thr Ser Ser Thr Ser Leu Phe Ser Tyr Tyr Asn Ser His Asp Ser 
        515                 520                 525             


Leu Ser Leu Asn Ser Pro Thr Asn Ile Ser Ser Leu Leu Asn Gln Glu 
    530                 535                 540                 


Ser Ala Val Leu Ala Thr Ala Pro Arg Ile Asp Asp Glu Ile Pro Pro 
545                 550                 555                 560 


Pro Leu Pro Val Arg Thr Pro Glu Ser Phe Ile Val Val Glu Glu Ala 
                565                 570                 575     


Gly Glu Phe Ser Pro Asn Val Pro Lys Ser Leu Ser Ser Ala Val Lys 
            580                 585                 590         


Val Lys Ile Gly Thr Ser Leu Glu Trp Gly Gly Thr Ser Glu Pro Lys 
        595                 600                 605             


Lys Phe Asp Asp Ser Val Ile Leu Arg Pro Ser Lys Ser Val Lys Leu 
    610                 615                 620                 


Arg Ser Pro Lys Ser Glu Leu His Gln Asp Arg Ser Ser Pro Pro Pro 
625                 630                 635                 640 


Pro Leu Pro Glu Arg Thr Leu Glu Ser Phe Phe Leu Ala Asp Glu Asp 
                645                 650                 655     


Cys Met Gln Ala Gln Ser Ile Glu Thr Tyr Ser Thr Ser Tyr Pro Asp 
            660                 665                 670         


Thr Met Glu Asn Ser Thr Ser Ser Lys Gln Thr Leu Lys Thr Pro Gly 
        675                 680                 685             


Lys Ser Phe Thr Arg Ser Lys Ser Leu Lys Ile Leu Arg Asn Met Lys 
    690                 695                 700                 


Lys Ser Ile Cys Asn Ser Cys Pro Pro Asn Lys Pro Ala Glu Ser Val 
705                 710                 715                 720 


Gln Ser Asn Asn Ser Ser Ser Phe Leu Asn Phe Gly Phe Ala Asn Arg 
                725                 730                 735     


Phe Ser Lys Pro Lys Gly Pro Arg Asn Pro Pro Pro Thr Trp Asn Ile 
            740                 745                 750         


<210>  191
<211>  3825
<212>  DNA
<213>  Homo sapiens

<400>  191
ccggagaggt gttggagagc acaatggctg aacaagtcct tcctcaggct ttgtatttga       60

gcaatatgcg gaaagctgtg aagatacggg agagaactcc agaagacatt tttaaaccta      120

ctaatgggat cattcatcat tttaaaacca tgcaccgata cacactggaa atgttcagaa      180

cttgccagtt ttgtcctcag tttcgggaga tcatccacaa agccctcatc gacagaaaca      240

tccaggccac cctggaaagc cagaagaaac tcaactggtg tcgagaagtc cggaagcttg      300

tggcgctgaa aacgaacggt gacggcaatt gcctcatgca tgccacttct cagtacatgt      360

ggggcgttca ggacacagac ttggtactga ggaaggcgct gttcagcacg ctcaaggaaa      420

cagacacacg caactttaaa ttccgctggc aactggagtc tctcaaatct caggaatttg      480

ttgaaacggg gctttgctat gatactcgga actggaatga tgaatgggac aatcttatca      540

aaatggcttc cacagacaca cccatggccc gaagtggact tcagtacaac tcactggaag      600

aaatacacat atttgtcctt tgcaacatcc tcagaaggcc aatcattgtc atttcagaca      660

aaatgctaag aagtttggaa tcaggttcca atttcgcccc tttgaaagtg ggtggaattt      720

acttgcctct ccactggcct gcccaggaat gctacagata ccccattgtt ctcggctatg      780

acagccatca ttttgtaccc ttggtgaccc tgaaggacag tgggcctgaa atccgagctg      840

ttccacttgt taacagagac cggggaagat ttgaagactt aaaagttcac tttttgacag      900

atcctgaaaa tgagatgaag gagaagctct taaaagagta cttaatggtg atagaaatcc      960

ccgtccaagg ctgggaccat ggcacaactc atctcatcaa tgccgcaaag ttggatgaag     1020

ctaacttacc aaaagaaatc aatctggtag atgattactt tgaacttgtt cagcatgagt     1080

acaagaaatg gcaggaaaac agcgagcagg ggaggagaga ggggcacgcc cagaatccca     1140

tggaaccttc cgtgccccag ctttctctca tggatgtaaa atgtgaaacg cccaactgcc     1200

ccttcttcat gtctgtgaac acccagcctt tatgccatga gtgctcagag aggcggcaaa     1260

agaatcaaaa caaactccca aagctgaact ccaagccggg ccctgagggg ctccctggca     1320

tggcgctcgg ggcctctcgg ggagaagcct atgagccctt ggcgtggaac cctgaggagt     1380

ccactggggg gcctcattcg gccccaccga cagcacccag cccttttctg ttcagtgaga     1440

ccactgccat gaagtgcagg agccccggct gccccttcac actgaatgtg cagcacaacg     1500

gattttgtga acgttgccac aacgcccggc aacttcacgc cagccacgcc ccagaccaca     1560

caaggcactt ggatcccggg aagtgccaag cctgcctcca ggatgttacc aggacattta     1620

atgggatctg cagtacttgc ttcaaaagga ctacagcaga ggcctcctcc agcctcagca     1680

ccagcctccc tccttcctgt caccagcgtt ccaagtcaga tccctcgcgg ctcgtccgga     1740

gcccctcccc gcattcttgc cacagagctg gaaacgacgc ccctgctggc tgcctgtctc     1800

aagctgcacg gactcctggg gacaggacgg ggacgagcaa gtgcagaaaa gccggctgcg     1860

tgtattttgg gactccagaa aacaagggct tttgcacact gtgtttcatc gagtacagag     1920

aaaacaaaca ttttgctgct gcctcaggga aagtcagtcc cacagcgtcc aggttccaga     1980

acaccattcc gtgcctgggg agggaatgcg gcacccttgg aagcaccatg tttgaaggat     2040

actgccagaa gtgtttcatt gaagctcaga atcagagatt tcatgaggcc aaaaggacag     2100

aagagcaact gagatcgagc cagcgcagag atgtgcctcg aaccacacaa agcacctcaa     2160

ggcccaagtg cgcccgggcc tcctgcaaga acatcctggc ctgccgcagc gaggagctct     2220

gcatggagtg tcagcatccc aaccagagga tgggccctgg ggcccaccgg ggtgagcctg     2280

cccccgaaga cccccccaag cagcgttgcc gggcccccgc ctgtgatcat tttggcaatg     2340

ccaagtgcaa cggctactgc aacgaatgct ttcagttcaa gcagatgtat ggctaaccgg     2400

aaacaggtgg gtcacctcct gcaagaagtg gggcctcgag ctgtcagtca tcatggtgct     2460

atcctctgaa cccctcagct gccactgcaa cagtgggctt aagggtgtct gagcaggaga     2520

ggaaagataa gctcttcgtg gtgcccacga tgctcaggtt tggtaacccg ggagtgttcc     2580

caggtggcct tagaaagcaa agcttgtaac tggcaaggga tgatgtcaga ttcagcccaa     2640

ggttcctcct ctcctaccaa gcaggaggcc aggaacttct ttggacttgg aaggtgtgcg     2700

gggactggcc gaggcccctg caccctgcgc atcaggactg cttcatcgtc ttggctgaga     2760

aagggaaaag acacacaagt cgcgtgggtt ggagaagcca gagccattcc acctcccctc     2820

ccccagcatc tctcagagat gtgaagccag atcctcatgg cagcgaggcc ctctgcaaga     2880

agctcaagga agctcaggga aaatggacgt attcagagag tgtttgtagt tcatggtttt     2940

tccctacctg cccggttcct ttcctgagga cccggcagaa atgcagaacc atccatggac     3000

tgtgattctg aggctgctga gactgaacat gttcacattg acagaaaaac aagctgctct     3060

ttataatatg caccttttaa aaaattagaa tattttactg ggaagacgtg taactctttg     3120

ggttattact gtctttactt ctaaagaagt tagcttgaac tgaggagtaa aagtgtgtac     3180

atatataata tacccttaca ttatgtatga gggatttttt taaattatat tgaaatgctg     3240

ccctagaagt acaataggaa ggctaaataa taataacctg ttttctggtt gttgttgggg     3300

catgagcttg tgtatacact gcttgcataa actcaaccag ctgccttttt aaagggagct     3360

ctagtccttt ttgtgtaatt cactttattt attttattac aaacttcaag attatttaag     3420

cgaagatatt tcttcagctc tggggaaaat gccacagtgt tctcctgaga gaacatcctt     3480

gctttgagtc aggctgtggg caagttcctg accacaggga gtaaattggc ctctttgata     3540

cacttttgct tgcctcccca ggaaagaagg aattgcatcc aaggtataca tacatattca     3600

tcgatgtttc gtgcttctcc ttatgaaact ccagctatgt aataaaaaac tatactctgt     3660

gttctgttaa tgcctctgag tgtcctacct ccttggagat gagataggga aggagcaggg     3720

atgagactgg caatggtcac agggaaagat gtggcctttt gtgatggttt tattttctgt     3780

taacactgtg tcctgggggg gctgggaagt cccctgcatc ccatg                     3825


<210>  192
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Ala Glu Gln Val Leu Pro Gln Ala Leu Tyr Leu Ser Asn Met Arg 
1               5                   10                  15      


Lys Ala Val Lys Ile Arg Glu Arg Thr Pro Glu Asp Ile Phe Lys Pro 
            20                  25                  30          


Thr Asn Gly Ile Ile His His Phe Lys Thr Met His Arg Tyr Thr Leu 
        35                  40                  45              


Glu Met Phe Arg Thr Cys Gln Phe Cys Pro Gln Phe Arg Glu Ile Ile 
    50                  55                  60                  


His Lys Ala Leu Ile Asp Arg Asn Ile Gln Ala Thr Leu Glu Ser Gln 
65                  70                  75                  80  


Lys Lys Leu Asn Trp Cys Arg Glu Val Arg Lys Leu Val Ala Leu Lys 
                85                  90                  95      


Thr Asn Gly Asp Gly Asn Cys Leu Met His Ala Thr Ser Gln Tyr Met 
            100                 105                 110         


Trp Gly Val Gln Asp Thr Asp Leu Val Leu Arg Lys Ala Leu Phe Ser 
        115                 120                 125             


Thr Leu Lys Glu Thr Asp Thr Arg Asn Phe Lys Phe Arg Trp Gln Leu 
    130                 135                 140                 


Glu Ser Leu Lys Ser Gln Glu Phe Val Glu Thr Gly Leu Cys Tyr Asp 
145                 150                 155                 160 


Thr Arg Asn Trp Asn Asp Glu Trp Asp Asn Leu Ile Lys Met Ala Ser 
                165                 170                 175     


Thr Asp Thr Pro Met Ala Arg Ser Gly Leu Gln Tyr Asn Ser Leu Glu 
            180                 185                 190         


Glu Ile His Ile Phe Val Leu Cys Asn Ile Leu Arg Arg Pro Ile Ile 
        195                 200                 205             


Val Ile Ser Asp Lys Met Leu Arg Ser Leu Glu Ser Gly Ser Asn Phe 
    210                 215                 220                 


Ala Pro Leu Lys Val Gly Gly Ile Tyr Leu Pro Leu His Trp Pro Ala 
225                 230                 235                 240 


Gln Glu Cys Tyr Arg Tyr Pro Ile Val Leu Gly Tyr Asp Ser His His 
                245                 250                 255     


Phe Val Pro Leu Val Thr Leu Lys Asp Ser Gly Pro Glu Ile Arg Ala 
            260                 265                 270         


Val Pro Leu Val Asn Arg Asp Arg Gly Arg Phe Glu Asp Leu Lys Val 
        275                 280                 285             


His Phe Leu Thr Asp Pro Glu Asn Glu Met Lys Glu Lys Leu Leu Lys 
    290                 295                 300                 


Glu Tyr Leu Met Val Ile Glu Ile Pro Val Gln Gly Trp Asp His Gly 
305                 310                 315                 320 


Thr Thr His Leu Ile Asn Ala Ala Lys Leu Asp Glu Ala Asn Leu Pro 
                325                 330                 335     


Lys Glu Ile Asn Leu Val Asp Asp Tyr Phe Glu Leu Val Gln His Glu 
            340                 345                 350         


Tyr Lys Lys Trp Gln Glu Asn Ser Glu Gln Gly Arg Arg Glu Gly His 
        355                 360                 365             


Ala Gln Asn Pro Met Glu Pro Ser Val Pro Gln Leu Ser Leu Met Asp 
    370                 375                 380                 


Val Lys Cys Glu Thr Pro Asn Cys Pro Phe Phe Met Ser Val Asn Thr 
385                 390                 395                 400 


Gln Pro Leu Cys His Glu Cys Ser Glu Arg Arg Gln Lys Asn Gln Asn 
                405                 410                 415     


Lys Leu Pro Lys Leu Asn Ser Lys Pro Gly Pro Glu Gly Leu Pro Gly 
            420                 425                 430         


Met Ala Leu Gly Ala Ser Arg Gly Glu Ala Tyr Glu Pro Leu Ala Trp 
        435                 440                 445             


Asn Pro Glu Glu Ser Thr Gly Gly Pro His Ser Ala Pro Pro Thr Ala 
    450                 455                 460                 


Pro Ser Pro Phe Leu Phe Ser Glu Thr Thr Ala Met Lys Cys Arg Ser 
465                 470                 475                 480 


Pro Gly Cys Pro Phe Thr Leu Asn Val Gln His Asn Gly Phe Cys Glu 
                485                 490                 495     


Arg Cys His Asn Ala Arg Gln Leu His Ala Ser His Ala Pro Asp His 
            500                 505                 510         


Thr Arg His Leu Asp Pro Gly Lys Cys Gln Ala Cys Leu Gln Asp Val 
        515                 520                 525             


Thr Arg Thr Phe Asn Gly Ile Cys Ser Thr Cys Phe Lys Arg Thr Thr 
    530                 535                 540                 


Ala Glu Ala Ser Ser Ser Leu Ser Thr Ser Leu Pro Pro Ser Cys His 
545                 550                 555                 560 


Gln Arg Ser Lys Ser Asp Pro Ser Arg Leu Val Arg Ser Pro Ser Pro 
                565                 570                 575     


His Ser Cys His Arg Ala Gly Asn Asp Ala Pro Ala Gly Cys Leu Ser 
            580                 585                 590         


Gln Ala Ala Arg Thr Pro Gly Asp Arg Thr Gly Thr Ser Lys Cys Arg 
        595                 600                 605             


Lys Ala Gly Cys Val Tyr Phe Gly Thr Pro Glu Asn Lys Gly Phe Cys 
    610                 615                 620                 


Thr Leu Cys Phe Ile Glu Tyr Arg Glu Asn Lys His Phe Ala Ala Ala 
625                 630                 635                 640 


Ser Gly Lys Val Ser Pro Thr Ala Ser Arg Phe Gln Asn Thr Ile Pro 
                645                 650                 655     


Cys Leu Gly Arg Glu Cys Gly Thr Leu Gly Ser Thr Met Phe Glu Gly 
            660                 665                 670         


Tyr Cys Gln Lys Cys Phe Ile Glu Ala Gln Asn Gln Arg Phe His Glu 
        675                 680                 685             


Ala Lys Arg Thr Glu Glu Gln Leu Arg Ser Ser Gln Arg Arg Asp Val 
    690                 695                 700                 


Pro Arg Thr Thr Gln Ser Thr Ser Arg Pro Lys Cys Ala Arg Ala Ser 
705                 710                 715                 720 


Cys Lys Asn Ile Leu Ala Cys Arg Ser Glu Glu Leu Cys Met Glu Cys 
                725                 730                 735     


Gln His Pro Asn Gln Arg Met Gly Pro Gly Ala His Arg Gly Glu Pro 
            740                 745                 750         


Ala Pro Glu Asp Pro Pro Lys Gln Arg Cys Arg Ala Pro Ala Cys Asp 
        755                 760                 765             


His Phe Gly Asn Ala Lys Cys Asn Gly Tyr Cys Asn Glu Cys Phe Gln 
    770                 775                 780                 


Phe Lys Gln Met Tyr Gly 
785                 790 


<210>  193
<211>  2588
<212>  DNA
<213>  Homo sapiens

<400>  193
gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac       60

ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag      120

tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg      180

ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca      240

acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa      300

gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa      360

tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg      420

agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt      480

tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt      540

gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac      600

aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag      660

gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc      720

agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa      780

gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat      840

gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga      900

aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt      960

ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag     1020

aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta     1080

cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta     1140

aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga     1200

agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg     1260

agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt     1320

aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca     1380

cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg     1440

atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca     1500

accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa     1560

ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat     1620

caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc     1680

acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg     1740

cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat     1800

gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc     1860

acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac     1920

cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg     1980

tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt     2040

cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa     2100

cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat     2160

gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct     2220

ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt     2280

cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc     2340

tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc     2400

acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc     2460

tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac     2520

caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat     2580

attaacag                                                              2588


<210>  194
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Ser Gln Trp Asn Gln Val Gln Gln Leu Glu Ile Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val Asp Gln Phe Tyr Asp Asp Asn Phe Pro Met Glu Ile Arg His 
            20                  25                  30          


Leu Leu Ala Gln Trp Ile Glu Asn Gln Asp Trp Glu Ala Ala Ser Asn 
        35                  40                  45              


Asn Glu Thr Met Ala Thr Ile Leu Leu Gln Asn Leu Leu Ile Gln Leu 
    50                  55                  60                  


Asp Glu Gln Leu Gly Arg Val Ser Lys Glu Lys Asn Leu Leu Leu Ile 
65                  70                  75                  80  


His Asn Leu Lys Arg Ile Arg Lys Val Leu Gln Gly Lys Phe His Gly 
                85                  90                  95      


Asn Pro Met His Val Ala Val Val Ile Ser Asn Cys Leu Arg Glu Glu 
            100                 105                 110         


Arg Arg Ile Leu Ala Ala Ala Asn Met Pro Val Gln Gly Pro Leu Glu 
        115                 120                 125             


Lys Ser Leu Gln Ser Ser Ser Val Ser Glu Arg Gln Arg Asn Val Glu 
    130                 135                 140                 


His Lys Val Ala Ala Ile Lys Asn Ser Val Gln Met Thr Glu Gln Asp 
145                 150                 155                 160 


Thr Lys Tyr Leu Glu Asp Leu Gln Asp Glu Phe Asp Tyr Arg Tyr Lys 
                165                 170                 175     


Thr Ile Gln Thr Met Asp Gln Ser Asp Lys Asn Ser Ala Met Val Asn 
            180                 185                 190         


Gln Glu Val Leu Thr Leu Gln Glu Met Leu Asn Ser Leu Asp Phe Lys 
        195                 200                 205             


Arg Lys Glu Ala Leu Ser Lys Met Thr Gln Ile Ile His Glu Thr Asp 
    210                 215                 220                 


Leu Leu Met Asn Thr Met Leu Ile Glu Glu Leu Gln Asp Trp Lys Arg 
225                 230                 235                 240 


Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Leu His Asn Gly Leu Asp 
                245                 250                 255     


Gln Leu Gln Asn Cys Phe Thr Leu Leu Ala Glu Ser Leu Phe Gln Leu 
            260                 265                 270         


Arg Arg Gln Leu Glu Lys Leu Glu Glu Gln Ser Thr Lys Met Thr Tyr 
        275                 280                 285             


Glu Gly Asp Pro Ile Pro Met Gln Arg Thr His Met Leu Glu Arg Val 
    290                 295                 300                 


Thr Phe Leu Ile Tyr Asn Leu Phe Lys Asn Ser Phe Val Val Glu Arg 
305                 310                 315                 320 


Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys Thr 
                325                 330                 335     


Leu Ile Gln Phe Thr Val Lys Leu Arg Leu Leu Ile Lys Leu Pro Glu 
            340                 345                 350         


Leu Asn Tyr Gln Val Lys Val Lys Ala Ser Ile Asp Lys Asn Val Ser 
        355                 360                 365             


Thr Leu Ser Asn Arg Arg Phe Val Leu Cys Gly Thr Asn Val Lys Ala 
    370                 375                 380                 


Met Ser Ile Glu Glu Ser Ser Asn Gly Ser Leu Ser Val Glu Phe Arg 
385                 390                 395                 400 


His Leu Gln Pro Lys Glu Met Lys Ser Ser Ala Gly Gly Lys Gly Asn 
                405                 410                 415     


Glu Gly Cys His Met Val Thr Glu Glu Leu His Ser Ile Thr Phe Glu 
            420                 425                 430         


Thr Gln Ile Cys Leu Tyr Gly Leu Thr Ile Asp Leu Glu Thr Ser Ser 
        435                 440                 445             


Leu Pro Val Val Met Ile Ser Asn Val Ser Gln Leu Pro Asn Ala Trp 
    450                 455                 460                 


Ala Ser Ile Ile Trp Tyr Asn Val Ser Thr Asn Asp Ser Gln Asn Leu 
465                 470                 475                 480 


Val Phe Phe Asn Asn Pro Pro Pro Ala Thr Leu Ser Gln Leu Leu Glu 
                485                 490                 495     


Val Met Ser Trp Gln Phe Ser Ser Tyr Val Gly Arg Gly Leu Asn Ser 
            500                 505                 510         


Asp Gln Leu His Met Leu Ala Glu Lys Leu Thr Val Gln Ser Ser Tyr 
        515                 520                 525             


Ser Asp Gly His Leu Thr Trp Ala Lys Phe Cys Lys Glu His Leu Pro 
    530                 535                 540                 


Gly Lys Ser Phe Thr Phe Trp Thr Trp Leu Glu Ala Ile Leu Asp Leu 
545                 550                 555                 560 


Ile Lys Lys His Ile Leu Pro Leu Trp Ile Asp Gly Tyr Val Met Gly 
                565                 570                 575     


Phe Val Ser Lys Glu Lys Glu Arg Leu Leu Leu Lys Asp Lys Met Pro 
            580                 585                 590         


Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser His Leu Gly Gly Ile Thr 
        595                 600                 605             


Phe Thr Trp Val Asp His Ser Glu Ser Gly Glu Val Arg Phe His Ser 
    610                 615                 620                 


Val Glu Pro Tyr Asn Lys Gly Arg Leu Ser Ala Leu Pro Phe Ala Asp 
625                 630                 635                 640 


Ile Leu Arg Asp Tyr Lys Val Ile Met Ala Glu Asn Ile Pro Glu Asn 
                645                 650                 655     


Pro Leu Lys Tyr Leu Tyr Pro Asp Ile Pro Lys Asp Lys Ala Phe Gly 
            660                 665                 670         


Lys His Tyr Ser Ser Gln Pro Cys Glu Val Ser Arg Pro Thr Glu Arg 
        675                 680                 685             


Gly Asp Lys Gly Tyr Val Pro Ser Val Phe Ile Pro Ile Ser Thr Ile 
    690                 695                 700                 


Arg Ser Asp Ser Thr Glu Pro His Ser Pro Ser Asp Leu Leu Pro Met 
705                 710                 715                 720 


Ser Pro Ser Val Tyr Ala Val Leu Arg Glu Asn Leu Ser Pro Thr Thr 
                725                 730                 735     


Ile Glu Thr Ala Met Lys Ser Pro Tyr Ser Ala Glu 
            740                 745             


<210>  195
<211>  1125
<212>  DNA
<213>  Homo sapiens

<400>  195
atgagcgggg aatcaatgaa tttcagcgat gttttcgact ccagtgaaga ttattttgtg       60

tcagtcaata cttcatatta ctcagttgat tctgagatgt tactgtgctc cttgcaggag      120

gtcaggcagt tctccaggct atttgtaccg attgcctact ccttgatctg tgtctttggc      180

ctcctgggga atattctggt ggtgatcacc tttgcttttt ataagaaggc caggtctatg      240

acagacgtct atctcttgaa catggccatt gcagacatcc tctttgttct tactctccca      300

ttctgggcag tgagtcatgc cactggtgcg tgggttttca gcaatgccac gtgcaagttg      360

ctaaaaggca tctatgccat caactttaac tgcgggatgc tgctcctgac ttgcattagc      420

atggaccggt acatcgccat tgtacaggcg actaagtcat tccggctccg atccagaaca      480

ctaccgcgca gcaaaatcat ctgccttgtt gtgtgggggc tgtcagtcat catctccagc      540

tcaacttttg tcttcaacca aaaatacaac acccaaggca gcgatgtctg tgaacccaag      600

taccagactg tctcggagcc catcaggtgg aagctgctga tgttggggct tgagctactc      660

tttggtttct ttatcccttt gatgttcatg atattttgtt acacgttcat tgtcaaaacc      720

ttggtgcaag ctcagaattc taaaaggcac aaagccatcc gtgtaatcat agctgtggtg      780

cttgtgtttc tggcttgtca gattcctcat aacatggtcc tgcttgtgac ggctgcaaat      840

ttgggtaaaa tgaaccgatc ctgccagagc gaaaagctaa ttggctatac gaaaactgtc      900

acagaagtcc tggctttcct gcactgctgc ctgaaccctg tgctctacgc ttttattggg      960

cagaagttca gaaactactt tctgaagatc ttgaaggacc tgtggtgtgt gagaaggaag     1020

tacaagtcct caggcttctc ctgtgccggg aggtactcag aaaacatttc tcggcagacc     1080

agtgagaccg cagataacga caatgcgtcg tccttcacta tgtga                     1125


<210>  196
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  197
<211>  2258
<212>  DNA
<213>  Homo sapiens

<400>  197
ctcctccagc tcttcctgtc ccgctgttgc aacactgcct cactcttccc ctcccacctt       60

ctctcccctc ctctctgctt taattttctc agaattctct ggactgaggc tccagttctg      120

gcctttgggg ttcaagatca ctgggaccag gccgtgatct ctatgcccga gtctcaaccc      180

tcaactgtca ccccaaggca cttgggacgt cctggacaga ccgagtcccg ggaagcccca      240

gcactgccgc tgccacactg ccctgagccc aaatggggga gtgagaggcc atagctgtct      300

ggcatgggcc tctccaccgt gcctgacctg ctgctgccac tggtgctcct ggagctgttg      360

gtgggaatat acccctcagg ggttattgga ctggtccctc acctagggga cagggagaag      420

agagatagtg tgtgtcccca aggaaaatat atccaccctc aaaataattc gatttgctgt      480

accaagtgcc acaaaggaac ctacttgtac aatgactgtc caggcccggg gcaggatacg      540

gactgcaggg agtgtgagag cggctccttc accgcttcag aaaaccacct cagacactgc      600

ctcagctgct ccaaatgccg aaaggaaatg ggtcaggtgg agatctcttc ttgcacagtg      660

gaccgggaca ccgtgtgtgg ctgcaggaag aaccagtacc ggcattattg gagtgaaaac      720

cttttccagt gcttcaattg cagcctctgc ctcaatggga ccgtgcacct ctcctgccag      780

gagaaacaga acaccgtgtg cacctgccat gcaggtttct ttctaagaga aaacgagtgt      840

gtctcctgta gtaactgtaa gaaaagcctg gagtgcacga agttgtgcct accccagatt      900

gagaatgtta agggcactga ggactcaggc accacagtgc tgttgcccct ggtcattttc      960

tttggtcttt gccttttatc cctcctcttc attggtttaa tgtatcgcta ccaacggtgg     1020

aagtccaagc tctactccat tgtttgtggg aaatcgacac ctgaaaaaga gggggagctt     1080

gaaggaacta ctactaagcc cctggcccca aacccaagct tcagtcccac tccaggcttc     1140

acccccaccc tgggcttcag tcccgtgccc agttccacct tcacctccag ctccacctat     1200

acccccggtg actgtcccaa ctttgcggct ccccgcagag aggtggcacc accctatcag     1260

ggggctgacc ccatccttgc gacagccctc gcctccgacc ccatccccaa cccccttcag     1320

aagtgggagg acagcgccca caagccacag agcctagaca ctgatgaccc cgcgacgctg     1380

tacgccgtgg tggagaacgt gcccccgttg cgctggaagg aattcgtgcg gcgcctaggg     1440

ctgagcgacc acgagatcga tcggctggag ctgcagaacg ggcgctgcct gcgcgaggcg     1500

caatacagca tgctggcgac ctggaggcgg cgcacgccgc ggcgcgaggc cacgctggag     1560

ctgctgggac gcgtgctccg cgacatggac ctgctgggct gcctggagga catcgaggag     1620

gcgctttgcg gccccgccgc cctcccgccc gcgcccagtc ttctcagatg aggctgcgcc     1680

cctgcgggca gctctaagga ccgtcctgcg agatcgcctt ccaaccccac ttttttctgg     1740

aaaggagggg tcctgcaggg gcaagcagga gctagcagcc gcctacttgg tgctaacccc     1800

tcgatgtaca tagcttttct cagctgcctg cgcgccgccg acagtcagcg ctgtgcgcgc     1860

ggagagaggt gcgccgtggg ctcaagagcc tgagtgggtg gtttgcgagg atgagggacg     1920

ctatgcctca tgcccgtttt gggtgtcctc accagcaagg ctgctcgggg gcccctggtt     1980

cgtccctgag cctttttcac agtgcataag cagttttttt tgtttttgtt ttgttttgtt     2040

ttgtttttaa atcaatcatg ttacactaat agaaacttgg cactcctgtg ccctctgcct     2100

ggacaagcac atagcaagct gaactgtcct aaggcagggg cgagcacgga acaatggggc     2160

cttcagctgg agctgtggac ttttgtacat acactaaaat tctgaagtta aagctctgct     2220

cttggaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                             2258


<210>  198
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
        195                 200                 205             


Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu 
    210                 215                 220                 


Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys 
225                 230                 235                 240 


Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu 
                245                 250                 255     


Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser 
            260                 265                 270         


Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val 
        275                 280                 285             


Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys 
    290                 295                 300                 


Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly 
305                 310                 315                 320 


Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn 
                325                 330                 335     


Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp 
            340                 345                 350         


Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro 
        355                 360                 365             


Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu 
    370                 375                 380                 


Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
385                 390                 395                 400 


Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala 
                405                 410                 415     


Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly 
            420                 425                 430         


Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro 
        435                 440                 445             


Pro Ala Pro Ser Leu Leu Arg 
    450                 455 


<210>  199
<211>  2394
<212>  DNA
<213>  Homo sapiens

<400>  199
gaattcggcg cagcggagcc tggagagaag gcgctgggct gcgagggcgc gagggcgcga       60

gggcaggggg caaccggacc ccgcccgcac ccatggcgcc cgtcgccgtc tgggccgcgc      120

tggccgtcgg actggagctc tgggctgcgg cgcacgcctt gcccgcccag gtggcattta      180

caccctacgc cccggagccc gggagcacat gccggctcag agaatactat gaccagacag      240

ctcagatgtg ctgcagcaag tgctcgccgg gccaacatgc aaaagtcttc tgtaccaaga      300

cctcggacac cgtgtgtgac tcctgtgagg acagcacata cacccagctc tggaactggg      360

ttcccgagtg cttgagctgt ggctcccgct gtagctctga ccaggtggaa actcaagcct      420

gcactcggga acagaaccgc atctgcacct gcaggcccgg ctggtactgc gcgctgagca      480

agcaggaggg gtgccggctg tgcgcgccgc tgcgcaagtg ccgcccgggc ttcggcgtgg      540

ccagaccagg aactgaaaca tcagacgtgg tgtgcaagcc ctgtgccccg gggacgttct      600

ccaacacgac ttcatccacg gatatttgca ggccccacca gatctgtaac gtggtggcca      660

tccctgggaa tgcaagcagg gatgcagtct gcacgtccac gtcccccacc cggagtatgg      720

ccccaggggc agtacactta ccccagccag tgtccacacg atcccaacac acgcagccaa      780

ctccagaacc cagcactgct ccaagcacct ccttcctgct cccaatgggc cccagccccc      840

cagctgaagg gagcactggc gacttcgctc ttccagttgg actgattgtg ggtgtgacag      900

ccttgggtct actaataata ggagtggtga actgtgtcat catgacccag gtgaaaaaga      960

agcccttgtg cctgcagaga gaagccaagg tgcctcactt gcctgccgat aaggcccggg     1020

gtacacaggg ccccgagcag cagcacctgc tgatcacagc gccgagctcc agcagcagct     1080

ccctggagag ctcggccagt gcgttggaca gaagggcgcc cactcggaac cagccacagg     1140

caccaggcgt ggaggccagt ggggccgggg aggcccgggc cagcaccggg agctcagatt     1200

cttcccctgg tggccatggg acccaggtca atgtcacctg catcgtgaac gtctgtagca     1260

gctctgacca cagctcacag tgctcctccc aagccagctc cacaatggga gacacagatt     1320

ccagcccctc ggagtccccg aaggacgagc aggtcccctt ctccaaggag gaatgtgcct     1380

ttcggtcaca gctggagacg ccagagaccc tgctggggag caccgaagag aagcccctgc     1440

cccttggagt gcctgatgct gggatgaagc ccagttaacc aggccggtgt gggctgtgtc     1500

gtagccaagg tgggctgagc cctggcagga tgaccctgcg aaggggccct ggtccttcca     1560

ggcccccacc actaggactc tgaggctctt tctgggccaa gttcctctag tgccctccac     1620

agccgcagcc tccctctgac ctgcaggcca agagcagagg cagcgggttg tggaaagcct     1680

ctgctgccat ggtgtgtccc tctcggaagg ctggctgggc atggacgttc ggggcatgct     1740

ggggcaagtc cctgactctc tgtgacctgc cccgcccagc tgcacctgcc agcctggctt     1800

ctggagccct tgggtttttt gtttgtttgt ttgtttgttt gtttgtttct ccccctgggc     1860

tctgccccag ctctggcttc cagaaaaccc cagcatcctt ttctgcagag gggctttctg     1920

gagaggaggg atgctgcctg agtcacccat gaagacagga cagtgcttca gcctgaggct     1980

gagactgcgg gatggtcctg gggctctgtg cagggaggag gtggcagccc tgtagggaac     2040

ggggtccttc aagttagctc aggaggcttg gaaagcatca cctcaggcca ggtgcagtcc     2100

ctcacgccta tgatcccagc actttgggag gctgaggcgg gtggatcacc tgaggttagg     2160

agttcgagac cagcctggcc aacatggtaa aaccccatct ctactaaaaa tacagaaatt     2220

agccgggcgt ggtggcgggc acctatagtc ccagctactc agaagcctga ggctgggaaa     2280

tcgtttgaac ccgggaagcg gaggttgcag ggagccgaga tcacgccact gcactccagc     2340

ctgggcgaca gagcgagagt ctgtctcaaa agaaaaaaaa aaaaaaccga attc           2394


<210>  200
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Arg Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly 
            260                 265                 270         


Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys 
        275                 280                 285             


Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro 
    290                 295                 300                 


Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu 
305                 310                 315                 320 


Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                325                 330                 335     


Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly 
            340                 345                 350         


Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
        355                 360                 365             


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
    370                 375                 380                 


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
385                 390                 395                 400 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro 
                405                 410                 415     


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser 
            420                 425                 430         


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    450                 455                 460     


<210>  201
<211>  1240
<212>  DNA
<213>  Homo sapiens

<400>  201
gacgtgaaga gtttaaagaa agagtattca aacgaaaatg cagttgtgaa gagaatgcag       60

tctcttcaac ttgattgtgt ggcagtacct tcaagccggt caaattcagc cacagaacag      120

cctggttcac tgcacagttc ccagggactt gggatgggtc ctgtggagga gtcctggttt      180

gctccttccc tggagcaccc acaagaagag aatgagccca gcctgcagag taaactccaa      240

gacgaagcca actaccatct ttatggcagc cgcatggaca ggcagacgaa acagcagccc      300

agacagaatg tggcttacaa cagagaggag gaaaggagac gcagggtctc ccatgaccct      360

tttgcacagc aaagacctta cgagaatttt cagaatacag agggaaaagg cactgtttat      420

tccagtgcag ccagtcatgg taatgcagtg caccagccat cagggctcac cagccaacct      480

caagtactgt atcagaacaa tggattatat agctcacatg gctttggaac aagaccactg      540

gatccaggaa cagcaggtcc cagagtttgg tacaggccaa ttccaagtca tatgcctagt      600

ctgcataata tcccagtgcc tgagaccaac tatctaggaa attctcccac catgccattc      660

agctccttgc caccaacaga tgaatctata aaatatacca tatacaatag tactggcatt      720

cagattggag cctacaatta tatggagatt ggtgggacga gttcatcact actagacagc      780

acaaatacga acttcaaaga agagccagct gctaagtacc aagctatctt tgataatacc      840

actagtctga cggataaaca cctggaccca atcagggaaa atctgggaaa gcactggaaa      900

aactgtgccc gtaaactggg cttcacacag tctcagattg atgaaattga ccatgactat      960

gagcgagatg gactgaaaga aaaggtttac cagatgctcc aaaagtgggt gatgagggaa     1020

ggcataaagg gagccacggt ggggaagctg gcccaggcgc tccaccagtg ttccaggatc     1080

gaccttctga gcagcttgat ttacgtcagc cagaactaac cctggatggg ctacggcagc     1140

tgaagtggac gcctcactta gtggataacc ccagaaagtt ggctgcctca gagcattcag     1200

aattctgtcc tcactgatag gggttctgtg tctgcagaaa                           1240


<210>  202
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  202

Asp Val Lys Ser Leu Lys Lys Glu Tyr Ser Asn Glu Asn Ala Val Val 
1               5                   10                  15      


Lys Arg Met Gln Ser Leu Gln Leu Asp Cys Val Ala Val Pro Ser Ser 
            20                  25                  30          


Arg Ser Asn Ser Ala Thr Glu Gln Pro Gly Ser Leu His Ser Ser Gln 
        35                  40                  45              


Gly Leu Gly Met Gly Pro Val Glu Glu Ser Trp Phe Ala Pro Ser Leu 
    50                  55                  60                  


Glu His Pro Gln Glu Glu Asn Glu Pro Ser Leu Gln Ser Lys Leu Gln 
65                  70                  75                  80  


Asp Glu Ala Asn Tyr His Leu Tyr Gly Ser Arg Met Asp Arg Gln Thr 
                85                  90                  95      


Lys Gln Gln Pro Arg Gln Asn Val Ala Tyr Asn Arg Glu Glu Glu Arg 
            100                 105                 110         


Arg Arg Arg Val Ser His Asp Pro Phe Ala Gln Gln Arg Pro Tyr Glu 
        115                 120                 125             


Asn Phe Gln Asn Thr Glu Gly Lys Gly Thr Val Tyr Ser Ser Ala Ala 
    130                 135                 140                 


Ser His Gly Asn Ala Val His Gln Pro Ser Gly Leu Thr Ser Gln Pro 
145                 150                 155                 160 


Gln Val Leu Tyr Gln Asn Asn Gly Leu Tyr Ser Ser His Gly Phe Gly 
                165                 170                 175     


Thr Arg Pro Leu Asp Pro Gly Thr Ala Gly Pro Arg Val Trp Tyr Arg 
            180                 185                 190         


Pro Ile Pro Ser His Met Pro Ser Leu His Asn Ile Pro Val Pro Glu 
        195                 200                 205             


Thr Asn Tyr Leu Gly Asn Ser Pro Thr Met Pro Phe Ser Ser Leu Pro 
    210                 215                 220                 


Pro Thr Asp Glu Ser Ile Lys Tyr Thr Ile Tyr Asn Ser Thr Gly Ile 
225                 230                 235                 240 


Gln Ile Gly Ala Tyr Asn Tyr Met Glu Ile Gly Gly Thr Ser Ser Ser 
                245                 250                 255     


Leu Leu Asp Ser Thr Asn Thr Asn Phe Lys Glu Glu Pro Ala Ala Lys 
            260                 265                 270         


Tyr Gln Ala Ile Phe Asp Asn Thr Thr Ser Leu Thr Asp Lys His Leu 
        275                 280                 285             


Asp Pro Ile Arg Glu Asn Leu Gly Lys His Trp Lys Asn Cys Ala Arg 
    290                 295                 300                 


Lys Leu Gly Phe Thr Gln Ser Gln Ile Asp Glu Ile Asp His Asp Tyr 
305                 310                 315                 320 


Glu Arg Asp Gly Leu Lys Glu Lys Val Tyr Gln Met Leu Gln Lys Trp 
                325                 330                 335     


Val Met Arg Glu Gly Ile Lys Gly Ala Thr Val Gly Lys Leu Ala Gln 
            340                 345                 350         


Ala Leu His Gln Cys Ser Arg Ile Asp Leu Leu Ser Ser Leu Ile Tyr 
        355                 360                 365             


Val Ser Gln Asn 
    370         


<210>  203
<211>  1496
<212>  DNA
<213>  Homo sapiens

<400>  203
gcacacccgg aagcggcgga gtagagcgga gcctggcggg cgtgggaacc caggccccgc       60

cgaggcggcc aggaggtgag atggcagctg ggcaaaatgg gcacgaagag tgggtgggca      120

gcgcatacct gtttgtggag tcctcgctgg acaaggtggt cctgtcggat gcctacgcgc      180

acccccagca gaaggtggca gtgtacaggg ctctgcaggc tgccttggca gagagcggcg      240

ggagcccgga cgtgctgcag atgctgaaga tccaccgcag cgacccgcag ctgatcgtgc      300

agctgcgatt ctgcgggcgg cagccctgtg gccgcttcct ccgcgcctac cgcgaggggg      360

cgctgcgcgc cgcgctgcag aggagcctgg cggccgcgct cgcccagcac tcggtgccgc      420

tgcaactgga gctgcgcgcc ggcgccgagc ggctggacgc tttgctggcg gacgaggagc      480

gctgtttgag ttgcatccta gcccagcagc ccgaccggct ccgggatgaa gaactggctg      540

agctggagga tgcgctgcga aatctgaagt gcggctcggg ggcccggggt ggcgacgggg      600

aggtcgcttc ggcccccttg cagcccccgg tgccctctct gtcggaggtg aagccgccgc      660

cgccgccgcc acctgcccag acttttctgt tccagggtca gcctgtagtg aatcggccgc      720

tgagcctgaa ggaccaacag acgttcgcgc gctctgtggg tctcaaatgg cgcaaggtgg      780

ggcgctcact gcagcgaggc tgccgggcgc tgcgggaccc ggcgctggac tcgctggcct      840

acgagtacga gcgcgaggga ctgtacgagc aggccttcca gctgctgcgg cgcttcgtgc      900

aggccgaggg ccgccgcgcc acgctgcagc gcctggtgga ggcactcgag gagaacgagc      960

tcaccagcct ggcagaggac ttgctgggcc tgaccgatcc caatggcggc ctggcctaga     1020

ccaggggtgc agccagcttt tggagaacct ggatggcctt agggttcctt ctgcggctat     1080

tgctgaaccc ctgtccatcc acgggaccct gaaactccac ttggcctatc tgctggacct     1140

gctggggcag agttgattgc cttccccagg agccagacca ctgggggtgc atcattgggg     1200

attctgcctc aggtactttg atagagtgtg gggtgggggg gacctgcttt ggagatcagc     1260

ctcaccttct cccatcccag aagcggggct tacagccagc ccttacagtt tcactcatga     1320

agcaccttga tctttggtgt cctggacttc atcctgggtg ctgcagatac tgcagtgaag     1380

taaaacagga atcaatcttg cctgccccca gctcacactc agcgtgggac cccgaatgtt     1440

aagcaatgat aataaagtat aacacggatt ttgatgtgag aaaaaaaaaa aaaaaa         1496


<210>  204
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Ala Ala Gly Gln Asn Gly His Glu Glu Trp Val Gly Ser Ala Tyr 
1               5                   10                  15      


Leu Phe Val Glu Ser Ser Leu Asp Lys Val Val Leu Ser Asp Ala Tyr 
            20                  25                  30          


Ala His Pro Gln Gln Lys Val Ala Val Tyr Arg Ala Leu Gln Ala Ala 
        35                  40                  45              


Leu Ala Glu Ser Gly Gly Ser Pro Asp Val Leu Gln Met Leu Lys Ile 
    50                  55                  60                  


His Arg Ser Asp Pro Gln Leu Ile Val Gln Leu Arg Phe Cys Gly Arg 
65                  70                  75                  80  


Gln Pro Cys Gly Arg Phe Leu Arg Ala Tyr Arg Glu Gly Ala Leu Arg 
                85                  90                  95      


Ala Ala Leu Gln Arg Ser Leu Ala Ala Ala Leu Ala Gln His Ser Val 
            100                 105                 110         


Pro Leu Gln Leu Glu Leu Arg Ala Gly Ala Glu Arg Leu Asp Ala Leu 
        115                 120                 125             


Leu Ala Asp Glu Glu Arg Cys Leu Ser Cys Ile Leu Ala Gln Gln Pro 
    130                 135                 140                 


Asp Arg Leu Arg Asp Glu Glu Leu Ala Glu Leu Glu Asp Ala Leu Arg 
145                 150                 155                 160 


Asn Leu Lys Cys Gly Ser Gly Ala Arg Gly Gly Asp Gly Glu Val Ala 
                165                 170                 175     


Ser Ala Pro Leu Gln Pro Pro Val Pro Ser Leu Ser Glu Val Lys Pro 
            180                 185                 190         


Pro Pro Pro Pro Pro Pro Ala Gln Thr Phe Leu Phe Gln Gly Gln Pro 
        195                 200                 205             


Val Val Asn Arg Pro Leu Ser Leu Lys Asp Gln Gln Thr Phe Ala Arg 
    210                 215                 220                 


Ser Val Gly Leu Lys Trp Arg Lys Val Gly Arg Ser Leu Gln Arg Gly 
225                 230                 235                 240 


Cys Arg Ala Leu Arg Asp Pro Ala Leu Asp Ser Leu Ala Tyr Glu Tyr 
                245                 250                 255     


Glu Arg Glu Gly Leu Tyr Glu Gln Ala Phe Gln Leu Leu Arg Arg Phe 
            260                 265                 270         


Val Gln Ala Glu Gly Arg Arg Ala Thr Leu Gln Arg Leu Val Glu Ala 
        275                 280                 285             


Leu Glu Glu Asn Glu Leu Thr Ser Leu Ala Glu Asp Leu Leu Gly Leu 
    290                 295                 300                 


Thr Asp Pro Asn Gly Gly Leu Ala 
305                 310         


<210>  205
<211>  4363
<212>  DNA
<213>  Homo sapiens

<400>  205
gcaggctgct ggagaaggcg cacctgctgc aggtgctccc ggccgccccg gaccagcgag       60

cgcgggcact gcggcgggga ggatgctgcg cgagcggacc gtgcggctgc agtacgggag      120

ccgcgtggag gcggtgtacg tgctgggcac ctacctctgg accgatgtct acagcgcggc      180

cccagccggg gcccaaacct tcagcctgaa gcactcggaa cacgtgtggg tggaggtggt      240

gcgtgatggg gaggctgagg aggtggccac caatggcaag cagcgctggc ttctctcgcc      300

cagcaccacc ctgcgggtca ccatgagcca ggcgagcacc gaggccagca gtgacaaggt      360

caccgtcaac tactatgacg aggaagggag cattcccatc gaccaggcgg ggctcttcct      420

cacagccatt gagatctccc tggatgtgga cgcagaccgg gatggtgtgg tggagaagaa      480

caacccaaag aaggcatcct ggacctgggg ccccgagggc cagggggcca tcctgctggt      540

gaactgtgac cgagagacac cctggttgcc caaggaggac tgccgtgatg agaaggtcta      600

cagcaaggaa gatctcaagg acatgtccca gatgatcctg cggaccaaag gccccgaccg      660

cctccccgcc ggatacgaga tagttctgta catttccatg tcagactcag acaaagtggg      720

cgtgttctac gtggagaacc cgttcttcgg ccaacgctat atccacatcc tgggccggcg      780

gaagctctac catgtggtca agtacacggg tggctccgcg gagctgctgt tcttcgtgga      840

aggcctctgt ttccccgacg agggcttctc aggcctggtc tccatccatg tcagcctgct      900

ggagtacatg gcccaggaca ttcccctgac tcccatcttc acggacaccg tgatattccg      960

gattgctccg tggatcatga cccccaacat cctgcctccc gtgtcggtgt ttgtgtgctg     1020

catgaaggat aattacctgt tcctgaaaga ggtgaagaac cttgtggaga aaaccaactg     1080

tgagctgaag gtctgcttcc agtacctaaa ccgaggcgat cgctggatcc aggatgaaat     1140

tgagtttggc tacatcgagg ccccccataa aggcttcccc gtggtgctgg actctccccg     1200

agatggaaac ctaaaggact tccctgtgaa ggagctcctg ggcccagatt ttggctacgt     1260

gacccgggag cccctctttg agtctgtcac cagccttgac tcatttggaa acctggaggt     1320

cagtccccca gtgaccgtga acggcaagac atacccgctt ggccgcatcc tcatcgggag     1380

cagctttcct ctgtctggtg gtcggaggat gaccaaggtg gtgcgtgact tcctgaaggc     1440

ccagcaggtg caggcgcccg tggagctcta ctcagactgg ctgactgtgg gccacgtgga     1500

tgagttcatg tcctttgtcc ccatccccgg cacaaagaaa ttcctgctac tcatggccag     1560

cacctcggcc tgctacaagc tcttccgaga gaagcagaag gacggccatg gagaggccat     1620

catgttcaaa ggcttgggtg ggatgagcag caagcgaatc accatcaaca agattctgtc     1680

caacgagagc cttgtgcagg agaacctgta cttccagcgc tgcctagact ggaaccgtga     1740

catcctcaag aaggagctgg gactgacaga gcaggacatc attgacctgc ccgctctgtt     1800

caagatggac gaggaccacc gtgccagagc cttcttccca aacatggtga acatgatcgt     1860

gctggacaag gacctgggca tccccaagcc attcgggcca caggttgagg aggaatgctg     1920

cctggagatg cacgtgcgtg gcctcctgga gcccctgggc ctcgaatgca ccttcatcga     1980

cgacatttct gcctaccaca aatttctggg ggaagtccac tgtggcacca acgtccgcag     2040

gaagcccttc accttcaagt ggtggcacat ggtgccctga cctgccaggg gccctggcgt     2100

ttgcctcctt cgcttagttc tccagaccct ccctcacacg cccagagcct tctgctgaca     2160

tggactggac agccccgctg ggagaccttt gggacgtggg gtggaatttg gggtatctgt     2220

gccttgccct ccctgagagg ggcctcagtg tcctctgaag ccatccccag tgagcctcga     2280

ctctgtccct gctgaaaata gctgggccag tgtctctgta gccctgacat aaggaacaga     2340

acacaacaaa acacagcaaa ccatgtgccc aaactgctcc ccaaagaatt ttgagtctct     2400

aatctgacac tgaatgaggg gagaagggaa ggagattctg ggattgccag ttcttccagc     2460

agccatgctc tgaaaatcaa ggtagaatcc atggaaaggg accccaggac cccgggaccc     2520

tagacgtatc ttgaactgcc atcgtcattt caaatacatc tccctcaggg tttccaggtg     2580

gccaccccca attattcatt ccttaccaac ctctcaaatc ctcttggctt tctctctgca     2640

gtgtggacac tgttggctag tcctccccac tccctgaggg tccagtaagt tagcttagaa     2700

ccttcctgga aacatttcat ctgagcaggt ttccccacgt gtgggatgct ccttttgcct     2760

catctgtctc agggatgcag gctcccccgc atgcatgggg atttctcccc agaccagcat     2820

acttgtgacc tgagagttca atgcgtaaag atgcccctgg tcagccatat ccatcttctc     2880

ttgcctggtc cttgattctc tggccgctcc ctgaccttcc tccttccact gccttgactt     2940

tcttcctttt tattcctggt gccatctgtc caggcagcta gacaagaact tgttcgccag     3000

cagccagatt caggccttcc caggggcata ataagtgacc agcccctcct ctccggacat     3060

cagatccaac acataaggac cctggcctac cctccagccc aacagccagt tctgggtcag     3120

ctgccaactt aggggtggtt tgattatccc attgaaattc accagtgcct ttgccaaaga     3180

ccctctcatt tggacatacc cagattcatt ccctggctcc aactgaaaag actcagtttc     3240

aatcgttaaa agttccttta gggccagaag aataaatgaa ttataatccc attttgaaga     3300

accgatttat aaccaatgaa aaggttataa tgtaatttat attcttggag gaacaagatt     3360

ttcatttggg attatttcct tcaaccattc aacaaacatt tgttgtatgc cactaagcgc     3420

caggcacggc gttgggctct gcaaacacag tggttagtag cagtctggac ctggtcccta     3480

ctggcatgga acccatcact ccccaacatg caaagcccac atttaaaggc cagcctctgc     3540

cccttcagtg atgcgctctt tagaaatgcc agtccactat attcagaaat ccgcagggca     3600

caaaacttcc agcaagtcac tgttgtggtg aaatgggcag tgggggtggg gggtcttctt     3660

taaacaggcc cccttcccat ctacctagcc agtacccatc caatgagtcc ccagagcctc     3720

cagaagctgt tgtctcctct ctggggacag cagctcctgc ctttggaggc caaagcccca     3780

gatctctcca gccccagagc tgaaaacacc aagtgcctat ttgagggtgt ctgtctggag     3840

acttagagtt tgtcatgtgt gtgtgtgtgt ttggttaatg tgggtttatg ggttttcttt     3900

cttttttttc tttttttttt tagtctacat tagggggaag tgagcgcctc ccatgtgcag     3960

acagtgtgtc tttatagatt tttctaaggc tttccccaat gatgtcggta atttctgatg     4020

tttctgaagt tcccaggact cacacacccg ttcccatctc acttgcccac ccagtgtgac     4080

aaccctcggt gtggatatac ccccgtggac tcatggctct tccccacccc cactttctat     4140

aaatgtaggc ctagaatacg cttctctgtt gcaaaactca gctaagttcc tgcttccacc     4200

ttgatgttga aatatcttat gtaagagggc aggggatgtc gtgaagatgg caagaagaac     4260

acagtttcaa atttctggaa aagagcctgt ggtggagatc taaagatgtt tagggaagag     4320

ctcgactaaa gaacaatgaa ataaatggtc caaggggaag tca                       4363


<210>  206
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Leu Arg Glu Arg Thr Val Arg Leu Gln Tyr Gly Ser Arg Val Glu 
1               5                   10                  15      


Ala Val Tyr Val Leu Gly Thr Tyr Leu Trp Thr Asp Val Tyr Ser Ala 
            20                  25                  30          


Ala Pro Ala Gly Ala Gln Thr Phe Ser Leu Lys His Ser Glu His Val 
        35                  40                  45              


Trp Val Glu Val Val Arg Asp Gly Glu Ala Glu Glu Val Ala Thr Asn 
    50                  55                  60                  


Gly Lys Gln Arg Trp Leu Leu Ser Pro Ser Thr Thr Leu Arg Val Thr 
65                  70                  75                  80  


Met Ser Gln Ala Ser Thr Glu Ala Ser Ser Asp Lys Val Thr Val Asn 
                85                  90                  95      


Tyr Tyr Asp Glu Glu Gly Ser Ile Pro Ile Asp Gln Ala Gly Leu Phe 
            100                 105                 110         


Leu Thr Ala Ile Glu Ile Ser Leu Asp Val Asp Ala Asp Arg Asp Gly 
        115                 120                 125             


Val Val Glu Lys Asn Asn Pro Lys Lys Ala Ser Trp Thr Trp Gly Pro 
    130                 135                 140                 


Glu Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Glu Thr Pro 
145                 150                 155                 160 


Trp Leu Pro Lys Glu Asp Cys Arg Asp Glu Lys Val Tyr Ser Lys Glu 
                165                 170                 175     


Asp Leu Lys Asp Met Ser Gln Met Ile Leu Arg Thr Lys Gly Pro Asp 
            180                 185                 190         


Arg Leu Pro Ala Gly Tyr Glu Ile Val Leu Tyr Ile Ser Met Ser Asp 
        195                 200                 205             


Ser Asp Lys Val Gly Val Phe Tyr Val Glu Asn Pro Phe Phe Gly Gln 
    210                 215                 220                 


Arg Tyr Ile His Ile Leu Gly Arg Arg Lys Leu Tyr His Val Val Lys 
225                 230                 235                 240 


Tyr Thr Gly Gly Ser Ala Glu Leu Leu Phe Phe Val Glu Gly Leu Cys 
                245                 250                 255     


Phe Pro Asp Glu Gly Phe Ser Gly Leu Val Ser Ile His Val Ser Leu 
            260                 265                 270         


Leu Glu Tyr Met Ala Gln Asp Ile Pro Leu Thr Pro Ile Phe Thr Asp 
        275                 280                 285             


Thr Val Ile Phe Arg Ile Ala Pro Trp Ile Met Thr Pro Asn Ile Leu 
    290                 295                 300                 


Pro Pro Val Ser Val Phe Val Cys Cys Met Lys Asp Asn Tyr Leu Phe 
305                 310                 315                 320 


Leu Lys Glu Val Lys Asn Leu Val Glu Lys Thr Asn Cys Glu Leu Lys 
                325                 330                 335     


Val Cys Phe Gln Tyr Leu Asn Arg Gly Asp Arg Trp Ile Gln Asp Glu 
            340                 345                 350         


Ile Glu Phe Gly Tyr Ile Glu Ala Pro His Lys Gly Phe Pro Val Val 
        355                 360                 365             


Leu Asp Ser Pro Arg Asp Gly Asn Leu Lys Asp Phe Pro Val Lys Glu 
    370                 375                 380                 


Leu Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Leu Phe Glu 
385                 390                 395                 400 


Ser Val Thr Ser Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro 
                405                 410                 415     


Val Thr Val Asn Gly Lys Thr Tyr Pro Leu Gly Arg Ile Leu Ile Gly 
            420                 425                 430         


Ser Ser Phe Pro Leu Ser Gly Gly Arg Arg Met Thr Lys Val Val Arg 
        435                 440                 445             


Asp Phe Leu Lys Ala Gln Gln Val Gln Ala Pro Val Glu Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Thr Val Gly His Val Asp Glu Phe Met Ser Phe Val Pro 
465                 470                 475                 480 


Ile Pro Gly Thr Lys Lys Phe Leu Leu Leu Met Ala Ser Thr Ser Ala 
                485                 490                 495     


Cys Tyr Lys Leu Phe Arg Glu Lys Gln Lys Asp Gly His Gly Glu Ala 
            500                 505                 510         


Ile Met Phe Lys Gly Leu Gly Gly Met Ser Ser Lys Arg Ile Thr Ile 
        515                 520                 525             


Asn Lys Ile Leu Ser Asn Glu Ser Leu Val Gln Glu Asn Leu Tyr Phe 
    530                 535                 540                 


Gln Arg Cys Leu Asp Trp Asn Arg Asp Ile Leu Lys Lys Glu Leu Gly 
545                 550                 555                 560 


Leu Thr Glu Gln Asp Ile Ile Asp Leu Pro Ala Leu Phe Lys Met Asp 
                565                 570                 575     


Glu Asp His Arg Ala Arg Ala Phe Phe Pro Asn Met Val Asn Met Ile 
            580                 585                 590         


Val Leu Asp Lys Asp Leu Gly Ile Pro Lys Pro Phe Gly Pro Gln Val 
        595                 600                 605             


Glu Glu Glu Cys Cys Leu Glu Met His Val Arg Gly Leu Leu Glu Pro 
    610                 615                 620                 


Leu Gly Leu Glu Cys Thr Phe Ile Asp Asp Ile Ser Ala Tyr His Lys 
625                 630                 635                 640 


Phe Leu Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe 
                645                 650                 655     


Thr Phe Lys Trp Trp His Met Val Pro 
            660                 665 


<210>  207
<211>  3189
<212>  DNA
<213>  Homo sapiens

<400>  207
agtgttgggg ttggcggcca cagctaagtc caacaccagc atgtcgctgc agagaatcgt       60

gcgtgtgtcc ctggagcatc ccaccagcgc ggtgtgtgtg gctggcgtgg agaccctcgt      120

ggacatttat gggtcagtgc ctgagggcac agaaatgttt gaggtctatg ggacgcctgg      180

cgtggacatc tacatctctc ccaacatgga gaggggccgg gagcgtgcag acaccaggcg      240

gtggcgcttt gacgcgactt tggagatcat cgtggtcatg aactccccca gcaatgacct      300

caacgacagc catgttcaga tttcctacca ctccagccat gagcctctgc ccctggccta      360

tgcggtgctc tacctcacct gtgttgacat ctctctggat tgcgacctga actgtgaggg      420

aaggcaggac aggaactttg tagacaagcg gcagtgggtc tgggggccca gtgggtatgg      480

cggcatcttg ctggtgaact gtgaccgtga tgatccgagc tgtgatgtcc aggacaattg      540

tgaccagcac gtgcactgcc tgcaagacct ggaagacatg tctgtcatgg tcctgcggac      600

gcagggccct gcagccctct ttgatgacca caaacttgtc ctccatacct ccagctatga      660

tgccaaacgg gcacaggtct tccacatctg cggtcctgag gatgtgtgtg aggcctatag      720

gcatgtgctg ggccaagata aggtgtccta tgaggtaccc cgcttgcatg gggatgagga      780

gcgcttcttc gtggaaggcc tgtccttccc tgatgccggc ttcacaggac tcatctcctt      840

ccatgtcact ctgctggacg actccaacga ggatttctcg gcatccccta tcttcactga      900

cactgtggtg ttccgagtgg caccctggat catgacgccc agcactctgc cacccctaga      960

ggtgtatgtg tgccgtgtga ggaacaacac gtgttttgtg gatgcggtgg cagagctggc     1020

caggaaggcc ggctgcaagc tgaccatctg cccacaggcc gagaaccgca acgaccgctg     1080

gatccaggat gagatggagc tgggctacgt tcaggcgccg cacaagaccc tcccggtggt     1140

ctttgactcc ccaaggaatg gggaactgca ggatttccct tacaaaagaa tcctgggtcc     1200

agattttggt tacgtgactc gggaaccacg cgacaggtct gtgagtggcc tggactcctt     1260

tgggaacctg gaggtcagcc ctccagtggt ggccaatggg aaagagtacc ccctggggag     1320

gatcctcatt gggggcaacc tgcctgggtc aagtggccgc agggtcaccc aggtggtgcg     1380

ggacttcctc catgcccaga aggtgcagcc ccccgtggag ctctttgtgg actggttggc     1440

cgtgggccat gtggatgagt ttctgagctt tgtccctgcc cccgatggga agggcttccg     1500

gatgctcctg gccagccctg gggcctgctt caagctcttc caggaaaagc agaagtgtgg     1560

ccacgggagg gccctcctgt tccagggggt tgttgatgat gagcaggtca agaccatctc     1620

catcaaccag gtgctctcca ataaagacct catcaactac aataagtttg tgcagagctg     1680

catcgactgg aaccgtgagg tgctgaagcg ggagctgggc ctggcagagt gtgacatcat     1740

tgacatccca cagctcttca agaccgagag gaaaaaagca acggccttct tccctgactt     1800

ggtgaacatg ctggtgctgg ggaagcacct gggcatcccc aagccctttg ggcccatcat     1860

caatggctgc tgctgcctgg aggagaaggt gcggtccctg ctggagccgc tgggcctcca     1920

ctgcaccttc attgatgact tcactccata ccacatgctg catggggagg tgcactgtgg     1980

caccaatgtg tgcagaaagc ccttctcttt caagtggtgg aacatggtgc cctgagacag     2040

ctcccaccca ccatcctgtc cccctggggc gggcattggc ccaggtggtg gagacagaga     2100

caggcccctg aacgataagc accaagagac cccaaggctc cagatggaac actgagggtg     2160

accgtccctc tcagaagcct tttccctgga agtgtccatg cctcacctgc aacccatgtg     2220

gttctcagac ttgaatcttc tcggcccccc aaaaagaagg acctcatttc ttatagcctc     2280

tcctgtgatt caacacaacc catggagatg tccccttctc actctgaaat catccatttg     2340

gggacaaatc cacattgggg tctagaaaca tccacgtatc tcatcagcca tcttgtcctg     2400

tgcatcctaa cagaggaagg atccatgatt ctgctttggt ccaattgctt cctctctgca     2460

gaggaacaac cctaaaacca gaccactcca cgcaggacag gcaggagaga ttcttcctaa     2520

agcctccccc ataaaaaggg agctgtggat ccacttagat cagggcggaa ccatctttca     2580

cccggccaag ctcctgccca gatgttgacc ctcacccagc gtgagctgtc acatagtagg     2640

agcttctaga tgcatgtgga agcaatgaga gttgtccctt agccttataa actccccatg     2700

atctgacatg cagaaatcca gccttgtcca gaatcctcct ggaatttctt ggagacgaaa     2760

gtatctgggg gattgttggg tactagggag actgggtaca agggtgaaaa gtagttccca     2820

taatacacat ggttgactat ggtgatccac cttgtgatgg ttaatattag gtgtctggag     2880

aaggttgctt cattggccct gggacttctc tctgcaggag gagagaacgc tgcctctcct     2940

ctggattggt ctcaggctct ctgttggcct ttggtcagcg tttccacatc ctgctctgct     3000

gcaggagagg gggctaaggg gctggatcca ccaaggcagc tcacagcggg aaaactctgg     3060

gaatgaacca ctgaattcag gggatggggg tgggggggcg gttctcgagg tgtgtgccag     3120

ctacacgtgt gttctgtatg ggtccagctg cgtttccatc actcgctaat aaatcaacag     3180

aaacacaaa                                                             3189


<210>  208
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Ile Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Val His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser 
385                 390                 395                 400 


Val Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Val Ala Asn Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly 
            420                 425                 430         


Asn Leu Pro Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp 
        435                 440                 445             


Phe Leu His Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp 
    450                 455                 460                 


Trp Leu Ala Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala 
465                 470                 475                 480 


Pro Asp Gly Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys 
                485                 490                 495     


Phe Lys Leu Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu 
            500                 505                 510         


Leu Phe Gln Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile 
        515                 520                 525             


Asn Gln Val Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val 
    530                 535                 540                 


Gln Ser Cys Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly 
545                 550                 555                 560 


Leu Ala Glu Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu 
                565                 570                 575     


Arg Lys Lys Ala Thr Ala Phe Phe Pro Asp Leu Val Asn Met Leu Val 
            580                 585                 590         


Leu Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn 
        595                 600                 605             


Gly Cys Cys Cys Leu Glu Glu Lys Val Arg Ser Leu Leu Glu Pro Leu 
    610                 615                 620                 


Gly Leu His Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu 
625                 630                 635                 640 


His Gly Glu Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser 
                645                 650                 655     


Phe Lys Trp Trp Asn Met Val Pro 
            660                 


<210>  209
<211>  1296
<212>  DNA
<213>  Homo sapiens

<400>  209
atgcccaacc ccaggcctgg caagccctcg gccccttcct tggcccttgg cccatcccca       60

ggagcctcgc ccagctggag ggctgcaccc aaagcctcag acctgctggg ggcccggggc      120

ccagggggaa ccttccaggg ccgagatctt cgaggcgggg cccatgcctc ctcttcttcc      180

ttgaacccca tgccaccatc gcagctgcag ctgcccacac tgcccctagt catggtggca      240

ccctccgggg cacggctggg ccccttgccc cacttacagg cactcctcca ggacaggcca      300

catttcatgc accagctctc aacggtggat gcccacgccc ggacccctgt gctgcaggtg      360

caccccctgg agagcccagc catgatcagc ctcacaccac ccaccaccgc cactggggtc      420

ttctccctca aggcccggcc tggcctccca cctgggatca acgtggccag cctggaatgg      480

gtgtccaggg agccggcact gctctgcacc ttcccaaatc ccagtgcacc caggaaggac      540

agcacccttt cggctgtgcc ccagagctcc tacccactgc tggcaaatgg tgtctgcaag      600

tggcccggat gtgagaaggt cttcgaagag ccagaggact tcctcaagca ctgccaggcg      660

gaccatcttc tggatgagaa gggcagggca caatgtctcc tccagagaga gatggtacag      720

tctctggagc agcagctggt gctggagaag gagaagctga gtgccatgca ggcccacctg      780

gctgggaaaa tggcactgac caaggcttca tctgtggcat catccgacaa gggctcctgc      840

tgcatcgtag ctgctggcag ccaaggccct gtcgtcccag cctggtctgg cccccgggag      900

gcccctgaca gcctgtttgc tgtccggagg cacctgtggg gtagccatgg aaacagcaca      960

ttcccagagt tcctccacaa catggactac ttcaagttcc acaacatgcg accccctttc     1020

acctacgcca cgctcatccg ctgggccatc ctggaggctc cagagaagca gcggacactc     1080

aatgagatct accactggtt cacacgcatg tttgccttct tcagaaacca tcctgccacc     1140

tggaagaacg ccatccgcca caacctgagt ctgcacaagt gctttgtgcg ggtggagagc     1200

gagaaggggg ctgtgtggac cgtggatgag ctggagttcc gcaagaaacg gagccagagg     1260

cccagcaggt gttccaaccc tacacctggc ccctga                               1296


<210>  210
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  211
<211>  3216
<212>  DNA
<213>  Homo sapiens

<400>  211
ggcagtttcc tggctgaaca cgccagccca atacttaaag agagcaactc ctgactccga       60

tagagactgg atggacccac aagggtgaca gcccaggcgg accgatcttc ccatcccaca      120

tcctccggcg cgatgccaaa aagaggctga cggcaactgg gccttctgca gagaaagacc      180

tccgcttcac tgccccggct ggtcccaagg gtcaggaaga tggattcata cctgctgatg      240

tggggactgc tcacgttcat catggtgcct ggctgccagg cagagctctg tgacgatgac      300

ccgccagaga tcccacacgc cacattcaaa gccatggcct acaaggaagg aaccatgttg      360

aactgtgaat gcaagagagg tttccgcaga ataaaaagcg ggtcactcta tatgctctgt      420

acaggaaact ctagccactc gtcctgggac aaccaatgtc aatgcacaag ctctgccact      480

cggaacacaa cgaaacaagt gacacctcaa cctgaagaac agaaagaaag gaaaaccaca      540

gaaatgcaaa gtccaatgca gccagtggac caagcgagcc ttccaggtca ctgcagggaa      600

cctccaccat gggaaaatga agccacagag agaatttatc atttcgtggt ggggcagatg      660

gtttattatc agtgcgtcca gggatacagg gctctacaca gaggtcctgc tgagagcgtc      720

tgcaaaatga cccacgggaa gacaaggtgg acccagcccc agctcatatg cacaggtgaa      780

atggagacca gtcagtttcc aggtgaagag aagcctcagg caagccccga aggccgtcct      840

gagagtgaga cttcctgcct cgtcacaaca acagattttc aaatacagac agaaatggct      900

gcaaccatgg agacgtccat atttacaaca gagtaccagg tagcagtggc cggctgtgtt      960

ttcctgctga tcagcgtcct cctcctgagt gggctcacct ggcagcggag acagaggaag     1020

agtagaagaa caatctagaa aaccaaaaga acaagaattt cttggtaaga agccgggaac     1080

agacaacaga agtcatgaag cccaagtgaa atcaaaggtg ctaaatggtc gcccaggaga     1140

catccgttgt gcttgcctgc gttttggaag ctctgaagtc acatcacagg acacggggca     1200

gtggcaacct tgtctctatg ccagctcagt cccatcagag agcgagcgct acccacttct     1260

aaatagcaat ttcgccgttg aagaggaagg gcaaaaccac tagaactctc catcttattt     1320

tcatgtatat gtgttcatta aagcatgaat ggtatggaac tctctccacc ctatatgtag     1380

tataaagaaa agtaggttta cattcatctc attccaactt cccagttcag gagtcccaag     1440

gaaagcccca gcactaacgt aaatacacaa cacacacact ctaccctata caactggaca     1500

ttgtctgcgt ggttcctttc tcagccgctt ctgactgctg attctcccgt tcacgttgcc     1560

taataaacat ccttcaagaa ctctgggctg ctacccagaa atcattttac ccttggctca     1620

atcctctaag ctaaccccct tctactgagc cttcagtctt gaatttctaa aaaacagagg     1680

ccatggcaga ataatctttg ggtaacttca aaacggggca gccaaaccca tgaggcaatg     1740

tcaggaacag aaggatgaat gaggtcccag gcagagaatc atacttagca aagttttacc     1800

tgtgcgttac taattggcct ctttaagagt tagtttcttt gggattgcta tgaatgatac     1860

cctgaatttg gcctgcacta atttgatgtt tacaggtgga cacacaaggt gcaaatcaat     1920

gcgtacgttt cctgagaagt gtctaaaaac accaaaaagg gatccgtaca ttcaatgttt     1980

atgcaaggaa ggaaagaaag aaggaagtga agagggagaa gggatggagg tcacactggt     2040

agaacgtaac cacggaaaag agcgcatcag gcctggcacg gtggctcagg cctataaccc     2100

cagctcccta ggagaccaag gcgggagcat ctcttgaggc caggagtttg agaccagcct     2160

gggcagcata gcaagacaca tccctacaaa aaattagaaa ttggctggat gtggtggcat     2220

acgcctgtag tcctagccac tcaggaggct gaggcaggag gattgcttga gcccaggagt     2280

tcgaggctgc agtcagtcat gatggcacca ctgcactcca gcctgggcaa cagagcaaga     2340

tcctgtcttt aaggaaaaaa agacaagatg agcataccag cagtccttga acattatcaa     2400

aaagttcagc atattagaat caccgggagg ccttgttaaa agagttcgct gggcccatct     2460

tcagagtctc tgagttgttg gtctggaata gagccaaatg ttttgtgtgt ctaacaattc     2520

ccaggtgctg ttgctgctgc tactattcca ggaacacact ttgagaacca ttgtgttatt     2580

gctctgcacg cccacccact ctcaactccc acgaaaaaaa tcaacttcca gagctaagat     2640

ttcggtggaa gtcctggttc catatctggt gcaagatctc ccctcacgaa tcagttgagt     2700

caacattcta gctcaacaac atcacacgat taacattaac gaaaattatt catttgggaa     2760

actatcagcc agttttcact tctgaagggg caggagagtg ttatgagaaa tcacggcagt     2820

tttcagcagg gtccagattc agattaaata actattttct gtcatttctg tgaccaacca     2880

catacaaaca gactcatctg tgcactctcc ccctccccct tcaggtatat gttttctgag     2940

taaagttgaa aagaatctca gaccagaaaa tatagatata tatttaaatc ttacttgagt     3000

agaactgatt acgacttttg ggtgttgagg ggtctataag atcaaaactt ttccatgata     3060

atactaagat gttatcgacc atttatctgt ccttctctca aaagtgtatg gtggaatttt     3120

ccagaagcta tgtgatacgt gatgatgtca tcactctgct gttaacatat aataaattta     3180

ttgctattgt ttataaaaga ataaatgata tttttt                               3216


<210>  212
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         


<210>  213
<211>  2740
<212>  DNA
<213>  Homo sapiens

<400>  213
aagaacgccc ccaaaatctg tttctaattt tacagaaatc ttttgaaact tggcacggta       60

ttcaaaagtc cgtggaaaga aaaaaacctt gtcctggctt cagcttccaa ctacaaagac      120

agacttggtc cttttcaacg gttttcacag atccagtgac ccacgctctg aagacagaat      180

tagctaactt tcaaaaacat ctggaaaaat gaagacttgg gtaaaaatcg tatttggagt      240

tgccacctct gctgtgcttg ccttattggt gatgtgcatt gtcttacgcc cttcaagagt      300

tcataactct gaagaaaata caatgagagc actcacactg aaggatattt taaatggaac      360

attttcttat aaaacatttt ttccaaactg gatttcagga caagaatatc ttcatcaatc      420

tgcagataac aatatagtac tttataatat tgaaacagga caatcatata ccattttgag      480

taatagaacc atgctttgga gatactctta cacagcaaca tattacatct atgaccttag      540

caatggagaa tttgtaagag gaaatgagct tcctcgtcca attcagtatt tatgctggtc      600

gcctgttggg agtaaattag catatgtcta tcaaaacaat atctatttga aacaaagacc      660

aggagatcca ccttttcaaa taacatttaa tggaagagaa aataaaatat ttaatggaat      720

cccagactgg gtttatgaag aggaaatgct tgctacaaaa tatgctctct ggtggtctcc      780

taatggaaaa tttttggcat atgcggaatt taatgatacg gatataccag ttattgccta      840

ttcctattat ggcgatgaac aatatcctag aacaataaat attccatacc caaaggctgg      900

agctaagaat cccgttgttc ggatatttat tatcgatacc acttaccctg cgtatgtagg      960

tccccaggaa gtgcctgttc cagcaatgat agcctcaagt gattattatt tcagttggct     1020

cacgtgggtt actgatgaac gagtatgttt gcagtggcta aaaagagtcc agaatgtttc     1080

ggtcctgtct atatgtgact tcagggaaga ctggcagaca tgggattgtc caaagaccca     1140

ggagcatata gaagaaagca gaactggatg ggctggtgga ttctttgttt caacaccagt     1200

tttcagctat gatgccattt cgtactacaa aatatttagt gacaaggatg gctacaaaca     1260

tattcactat atcaaagaca ctgtggaaaa tgctattcaa attacaagtg gcaagtggga     1320

ggccataaat atattcagag taacacagga ttcactgttt tattctagca atgaatttga     1380

agaataccct ggaagaagaa acatctacag aattagcatt ggaagctatc ctccaagcaa     1440

gaagtgtgtt acttgccatc taaggaaaga aaggtgccaa tattacacag caagtttcag     1500

cgactacgcc aagtactatg cacttgtctg ctacggccca ggcatcccca tttccaccct     1560

tcatgatgga cgcactgatc aagaaattaa aatcctggaa gaaaacaagg aattggaaaa     1620

tgctttgaaa aatatccagc tgcctaaaga ggaaattaag aaacttgaag tagatgaaat     1680

tactttatgg tacaagatga ttcttcctcc tcaatttgac agatcaaaga agtatccctt     1740

gctaattcaa gtgtatggtg gtccctgcag tcagagtgta aggtctgtat ttgctgttaa     1800

ttggatatct tatcttgcaa gtaaggaagg gatggtcatt gccttggtgg atggtcgagg     1860

aacagctttc caaggtgaca aactcctcta tgcagtgtat cgaaagctgg gtgtttatga     1920

agttgaagac cagattacag ctgtcagaaa attcatagaa atgggtttca ttgatgaaaa     1980

aagaatagcc atatggggct ggtcctatgg aggatacgtt tcatcactgg cccttgcatc     2040

tggaactggt cttttcaaat gtggtatagc agtggctcca gtctccagct gggaatatta     2100

cgcgtctgtc tacacagaga gattcatggg tctcccaaca aaggatgata atcttgagca     2160

ctataagaat tcaactgtga tggcaagagc agaatatttc agaaatgtag actatcttct     2220

catccacgga acagcagatg ataatgtgca ctttcaaaac tcagcacaga ttgctaaagc     2280

tctggttaat gcacaagtgg atttccaggc aatgtggtac tctgaccaga accacggctt     2340

atccggcctg tccacgaacc acttatacac ccacatgacc cacttcctaa agcagtgttt     2400

ctctttgtca gactaaaaac gatgcagatg caagcctgta tcagaatctg aaaaccttat     2460

ataaacccct cagacagttt gcttatttta ttttttatgt tgtaaaatgc tagtataaac     2520

aaacaaatta atgttgttct aaaggctgtt aaaaaaaaga tgaggactca gaagttcaag     2580

ctaaatattg tttacatttt ctggtactct gtgaaagaag agaaaaggga gtcatgcatt     2640

ttgctttgga cacagtgttt tatcacctgt tcatttgaag aaaaataata aagtcagaag     2700

ttcaagtgct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           2740


<210>  214
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Leu 
                85                  90                  95      


Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn 
            100                 105                 110         


Gly Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu 
        115                 120                 125             


Cys Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn 
    130                 135                 140                 


Ile Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe 
145                 150                 155                 160 


Asn Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr 
                165                 170                 175     


Glu Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn 
            180                 185                 190         


Gly Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val 
        195                 200                 205             


Ile Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn 
    210                 215                 220                 


Ile Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Ile Phe 
225                 230                 235                 240 


Ile Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro 
                245                 250                 255     


Val Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr 
            260                 265                 270         


Trp Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln 
        275                 280                 285             


Asn Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr 
    290                 295                 300                 


Trp Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly 
305                 310                 315                 320 


Trp Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala 
                325                 330                 335     


Ile Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile 
            340                 345                 350         


His Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly 
        355                 360                 365             


Lys Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe 
    370                 375                 380                 


Tyr Ser Ser Asn Glu Phe Glu Glu Tyr Pro Gly Arg Arg Asn Ile Tyr 
385                 390                 395                 400 


Arg Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys 
                405                 410                 415     


His Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp 
            420                 425                 430         


Tyr Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile 
        435                 440                 445             


Ser Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu 
    450                 455                 460                 


Glu Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys 
465                 470                 475                 480 


Glu Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys 
                485                 490                 495     


Met Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu 
            500                 505                 510         


Ile Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe 
        515                 520                 525             


Ala Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile 
    530                 535                 540                 


Ala Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu 
545                 550                 555                 560 


Tyr Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile 
                565                 570                 575     


Thr Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg 
            580                 585                 590         


Ile Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala 
        595                 600                 605             


Leu Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro 
    610                 615                 620                 


Val Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met 
625                 630                 635                 640 


Gly Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr 
                645                 650                 655     


Val Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile 
            660                 665                 670         


His Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile 
        675                 680                 685             


Ala Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr 
    690                 695                 700                 


Ser Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr 
705                 710                 715                 720 


Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp 
                725                 730                 735 


<210>  215
<211>  3913
<212>  DNA
<213>  Homo sapiens

<400>  215
ctttcactgg caagagacgg agtcctgggt ttcagttcca gttgcctgcg gtgggctgtg       60

tgagtttgcc aaagtcccct gccctctctg ggtctcggtt ccctcgcctg tccacgtgag      120

gttggaggag ctgaacgccg acgtcatttt tagctaagag ggagcagggt ccccgagtcg      180

ccggcccagg gtctgcgcat ccgaggccgc gcgccctttc ccctccccca cggctcctcc      240

gggccccgca ctctgcgccc cggctgccgc ccagcgccct acaccgccct cagggggccc      300

tcgcgggctc cccccggccg ggatgccagt gccccgcgcc acgcgcgcct gctcccgcgc      360

cgcctgccct gcagcctgcc cgcggcgcct ttatacccag cgggctcggc gctcactaat      420

gtttaactcg gggccgaaac ttgccagcgg cgagtgactc caccgcccgg agcagcggtg      480

caggacgcgc gtctccgccg cccgcggtga cttctgcctg cgctccttct ctgaacgctc      540

acttccgagg agacgccgac gatgaagaca ccgtggaagg ttcttctggg actgctgggt      600

gctgctgcgc ttgtcaccat catcaccgtg cccgtggttc tgctgaacaa aggcacagat      660

gatgctacag ctgacagtcg caaaacttac actctaactg attacttaaa aaatacttat      720

agactgaagt tatactcctt aagatggatt tcagatcatg aatatctcta caaacaagaa      780

aataatatct tggtattcaa tgctgaatat ggaaacagct cagttttctt ggagaacagt      840

acatttgatg agtttggaca ttctatcaat gattattcaa tatctcctga tgggcagttt      900

attctcttag aatacaacta cgtgaagcaa tggaggcatt cctacacagc ttcatatgac      960

atttatgatt taaataaaag gcagctgatt acagaagaga ggattccaaa caacacacag     1020

tgggtcacat ggtcaccagt gggtcataaa ttggcatatg tttggaacaa tgacatttat     1080

gttaaaattg aaccaaattt accaagttac agaatcacat ggacggggaa agaagatata     1140

atatataatg gaataactga ctgggtttat gaagaggaag tcttcagtgc ctactctgct     1200

ctgtggtggt ctccaaacgg cactttttta gcatatgccc aatttaacga cacagaagtc     1260

ccacttattg aatactcctt ctactctgat gagtcactgc agtacccaaa gactgtacgg     1320

gttccatatc caaaggcagg agctgtgaat ccaactgtaa agttctttgt tgtaaataca     1380

gactctctca gctcagtcac caatgcaact tccatacaaa tcactgctcc tgcttctatg     1440

ttgatagggg atcactactt gtgtgatgtg acatgggcaa cacaagaaag aatttctttg     1500

cagtggctca ggaggattca gaactattcg gtcatggata tttgtgacta tgatgaatcc     1560

agtggaagat ggaactgctt agtggcacgg caacacattg aaatgagtac tactggctgg     1620

gttggaagat ttaggccttc agaacctcat tttacccttg atggtaatag cttctacaag     1680

atcatcagca atgaagaagg ttacagacac atttgctatt tccaaataga taaaaaagac     1740

tgcacattta ttacaaaagg cacctgggaa gtcatcggga tagaagctct aaccagtgat     1800

tatctatact acattagtaa tgaatataaa ggaatgccag gaggaaggaa tctttataaa     1860

atccaactta gtgactatac aaaagtgaca tgcctcagtt gtgagctgaa tccggaaagg     1920

tgtcagtact attctgtgtc attcagtaaa gaggcgaagt attatcagct gagatgttcc     1980

ggtcctggtc tgcccctcta tactctacac agcagcgtga atgataaagg gctgagagtc     2040

ctggaagaca attcagcttt ggataaaatg ctgcagaatg tccagatgcc ctccaaaaaa     2100

ctggacttca ttattttgaa tgaaacaaaa ttttggtatc agatgatctt gcctcctcat     2160

tttgataaat ccaagaaata tcctctacta ttagatgtgt atgcaggccc atgtagtcaa     2220

aaagcagaca ctgtcttcag actgaactgg gccacttacc ttgcaagcac agaaaacatt     2280

atagtagcta gctttgatgg cagaggaagt ggttaccaag gagataagat catgcatgca     2340

atcaacagaa gactgggaac atttgaagtt gaagatcaaa ttgaagcagc cagacaattt     2400

tcaaaaatgg gatttgtgga caacaaacga attgcaattt ggggctggtc atatggaggg     2460

tacgtaacct caatggtcct gggatcggga agtggcgtgt tcaagtgtgg aatagccgtg     2520

gcgcctgtat cccggtggga gtactatgac tcagtgtaca cagaacgtta catgggtctc     2580

ccaactccag aagacaacct tgaccattac agaaattcaa cagtcatgag cagagctgaa     2640

aattttaaac aagttgagta cctccttatt catggaacag cagatgataa cgttcacttt     2700

cagcagtcag ctcagatctc caaagccctg gtcgatgttg gagtggattt ccaggcaatg     2760

tggtatactg atgaagacca tggaatagct agcagcacag cacaccaaca tatatatacc     2820

cacatgagcc acttcataaa acaatgtttc tctttacctt agcacctcaa aataccatgc     2880

catttaaagc ttattaaaac tcatttttgt tttcattatc tcaaaactgc actgtcaaga     2940

tgatgatgat ctttaaaata cacactcaaa tcaagaaact taaggttacc tttgttccca     3000

aatttcatac ctatcatctt aagtagggac ttctgtcttc acaacagatt attaccttac     3060

agaagtttga attatccggt cgggttttat tgtttaaaat catttctgca tcagctgctg     3120

aaacaacaaa taggaattgt ttttatggag gctttgcata gattccctga gcaggatttt     3180

aatctttttc taactggact ggttcaaatg ttgttctctt ctttaaaggg atggcaagat     3240

gtgggcagtg atgtcactag ggcagggaca ggataagagg gattagggag agaagatagc     3300

agggcatggc tgggaaccca agtccaagca taccaacacg agcaggctac tgtcagctcc     3360

cctcggagaa gagctgttca cagccagact ggcacagttt tctgagaaag actattcaaa     3420

cagtctcagg aaatcaaata tgcaaagcac tgacttctaa gtaaaaccac agcagttgaa     3480

aagactccaa agaaatgtaa gggaaactgc cagcaacgca ggcccccagg tgccagttat     3540

ggctataggt gctacaaaaa cacagcaagg gtgatgggaa agcattgtaa atgtgctttt     3600

aaaaaaaaat actgatgttc ctagtgaaag aggcagcttg aaactgagat gtgaacacat     3660

cagcttgccc tgttaaaaga tgaaaatatt tgtatcacaa atcttaactt gaaggagtcc     3720

ttgcatcaat ttttcttatt tcatttcttt gagtgtctta attaaaagaa tattttaact     3780

tccttggact cattttaaaa aatggaacat aaaatacaat gttatgtatt attattccca     3840

ttctacatac tatggaattt ctcccagtca tttaataaat gtgccttcat tttttcagaa     3900

aaaaaaaaaa aaa                                                        3913


<210>  216
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 
            20                  25                  30          


Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
        35                  40                  45              


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
    50                  55                  60                  


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
65                  70                  75                  80  


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp 
                85                  90                  95      


Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln 
            100                 105                 110         


Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr 
        115                 120                 125             


Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr 
    130                 135                 140                 


Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val 
145                 150                 155                 160 


Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile 
                165                 170                 175     


Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp 
            180                 185                 190         


Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe 
        195                 200                 205             


Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala 
    210                 215                 220                 


Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe 
225                 230                 235                 240 


Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr 
                245                 250                 255     


Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn 
            260                 265                 270         


Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr 
        275                 280                 285             


Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr 
    290                 295                 300                 


Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln 
305                 310                 315                 320 


Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg 
                325                 330                 335     


Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly 
            340                 345                 350         


Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly 
        355                 360                 365             


Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile 
    370                 375                 380                 


Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly 
385                 390                 395                 400 


Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr 
                405                 410                 415     


Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr 
            420                 425                 430         


Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu 
        435                 440                 445             


Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu 
    450                 455                 460                 


Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr 
465                 470                 475                 480 


Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp 
                485                 490                 495     


Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys 
            500                 505                 510         


Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met 
        515                 520                 525             


Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu 
    530                 535                 540                 


Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg 
545                 550                 555                 560 


Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala 
                565                 570                 575     


Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His 
            580                 585                 590         


Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu 
        595                 600                 605             


Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile 
    610                 615                 620                 


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu 
625                 630                 635                 640 


Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
                645                 650                 655     


Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly 
            660                 665                 670         


Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val 
        675                 680                 685             


Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His 
    690                 695                 700                 


Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser 
705                 710                 715                 720 


Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr 
                725                 730                 735     


Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr 
            740                 745                 750         


Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro 
        755                 760                 765     


<210>  217
<211>  2924
<212>  DNA
<213>  Homo sapiens

<400>  217
gacgccgacg atgaagacac cgtggaaggt tcttctggga ctgctgggtg ctgctgcgct       60

tgtcaccatc atcaccgtgc ccgtggttct gctgaacaaa ggcacagatg atgctacagc      120

tgacagtcgc aaaacttaca ctctaactga ttacttaaaa aatacttata gactgaagtt      180

atactcctta agatggattt cagatcatga atatctctac aaacaagaaa ataatatctt      240

ggtattcaat gctgaatatg gaaacagctc agttttcttg gagaacagta catttgatga      300

gtttggacat tctatcaatg attattcaat atctcctgat gggcagttta ttctcttaga      360

atacaactac gtgaagcaat ggaggcattc ctacacagct tcatatgaca tttatgattt      420

aaataaaagg cagctgatta cagaagagag gattccaaac aacacacagt gggtcacatg      480

gtcaccagtg ggtcataaat tggcatatgt ttggaacaat gacatttatg ttaaaattga      540

accaaattta ccaagttaca gaatcacatg gacggggaaa gaagatataa tatataatgg      600

aataactgac tgggtttatg aagaggaagt cttcagtgcc tactctgctc tgtggtggtc      660

tccaaacggc acttttttag catatgccca atttaacgac acagaagtcc cacttattga      720

atactccttc tactctgatg agtcactgca gtacccaaag actgtacggg ttccatatcc      780

aaaggcagga gctgtgaatc caactgtaaa gttctttgtt gtaaatacag actctctcag      840

ctcagtcacc aatgcaactt ccatacaaat cactgctcct gcttctatgt tgatagggga      900

tcactacttg tgtgatgtga catgggcaac acaagaaaga atttctttgc agtggctcag      960

gaggattcag aactattcgg tcatggatat ttgtgactat gatgaatcca gtggaagatg     1020

gaactgctta gtggcacggc aacacattga aatgagtact actggctggg ttggaagatt     1080

taggccttca gaacctcatt ttacccttga tggtaatagc ttctacaaga tcatcagcaa     1140

tgaagaaggt tacagacaca tttgctattt ccaaatagat aaaaaagact gcacatttat     1200

tacaaaaggc acctgggaag tcatcgggat agaagctcta accagtgatt atctatacta     1260

cattagtaat gaatataaag gaatgccagg aggaaggaat ctttataaaa tccaacttag     1320

tgactataca aaagtgacat gcctcagttg tgagctgaat ccggaaaggt gtcagtacta     1380

ttctgtgtca ttcagtaaag aggcgaagta ttatcagctg agatgttccg gtcctggtct     1440

gcccctctat actctacaca gcagcgtgaa tgataaaggg ctgagagtcc tggaagacaa     1500

ttcagctttg gataaaatgc tgcagaatgt ccagatgccc tccaaaaaac tggacttcat     1560

tattttgaat gaaacaaaat tttggtatca gatgatcttg cctcctcatt ttgataaatc     1620

caagaaatat cctctactat tagatgtgta tgcaggccca tgtagtcaaa aagcagacac     1680

tgtcttcaga ctgaactggg ccacttacct tgcaagcaca gaaaacatta tagtagctag     1740

ctttgatggc agaggaagtg gttaccaagg agataagatc atgcatgcaa tcaacagaag     1800

actgggaaca tttgaagttg aagatcaaat tgaagcagcc agacaatttt caaaaatggg     1860

atttgtggac aacaaacgaa ttgcaatttg gggctggtca tatggagggt acgtaacctc     1920

aatggtcctg ggatcaggaa gtggcgtgtt caagtgtgga atagccgtgg cgcctgtatc     1980

ccggtgggag tactatgact cagtgtacac agaacgttac atgggtctcc caactccaga     2040

agacaacctt gaccattaca gaaattcaac agtcatgagc agagctgaaa attttaaaca     2100

agttgagtac ctccttattc atggaacagc agatgataac gttcactttc agcagtcagc     2160

tcagatctcc aaagccctgg tcgatgttgg agtggatttc caggcaatgt ggtatactga     2220

tgaagaccat ggaatagcta gcagcacagc acaccaacat atatataccc acatgagcca     2280

cttcataaaa caatgtttct ctttacctta gcacctcaaa ataccatgcc atttaaagct     2340

tattaaaact catttttgtt ttcattatct caaaactgca ctgtcaagat gatgatgatc     2400

tttaaaatac acactcaaat caagaaactt aaggttacct ttgttcccaa atttcatacc     2460

tatcatctta agtagggact tctgtcttca caacagatta ttaccttaca gaagtttgaa     2520

ttatccggtc gggttttatt gtttaaaatc atttctgcat cagctgctga aacaacaaat     2580

aggaattgtt tttatggagg ctttgcatag attccctgag caggatttta atctttttct     2640

aactggactg gttcaaatgt tgttctcttc tttaaaggga tggcaagatg tgggcagtga     2700

tgtcactagg gcagggacag gataagaggg attagggaga gaagatagca gggcatggct     2760

gggaacccaa gtccaagcat accaacacga ccaggctact gtcagctccc ctcggagaaa     2820

actgtgcagt ctgcgtgtga acagctcttc tcctttagag cacaatggat ctcgagggat     2880

cttccatacc taccagttct gcgcctcgag gccgcgactc taga                      2924


<210>  218
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 
            20                  25                  30          


Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
        35                  40                  45              


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
    50                  55                  60                  


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
65                  70                  75                  80  


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp 
                85                  90                  95      


Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln 
            100                 105                 110         


Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr 
        115                 120                 125             


Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr 
    130                 135                 140                 


Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val 
145                 150                 155                 160 


Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile 
                165                 170                 175     


Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp 
            180                 185                 190         


Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe 
        195                 200                 205             


Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala 
    210                 215                 220                 


Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe 
225                 230                 235                 240 


Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr 
                245                 250                 255     


Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn 
            260                 265                 270         


Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr 
        275                 280                 285             


Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr 
    290                 295                 300                 


Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln 
305                 310                 315                 320 


Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg 
                325                 330                 335     


Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly 
            340                 345                 350         


Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly 
        355                 360                 365             


Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile 
    370                 375                 380                 


Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly 
385                 390                 395                 400 


Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr 
                405                 410                 415     


Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr 
            420                 425                 430         


Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu 
        435                 440                 445             


Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu 
    450                 455                 460                 


Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr 
465                 470                 475                 480 


Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp 
                485                 490                 495     


Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys 
            500                 505                 510         


Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met 
        515                 520                 525             


Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu 
    530                 535                 540                 


Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg 
545                 550                 555                 560 


Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala 
                565                 570                 575     


Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His 
            580                 585                 590         


Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu 
        595                 600                 605             


Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile 
    610                 615                 620                 


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu 
625                 630                 635                 640 


Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
                645                 650                 655     


Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly 
            660                 665                 670         


Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val 
        675                 680                 685             


Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His 
    690                 695                 700                 


Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser 
705                 710                 715                 720 


Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr 
                725                 730                 735     


Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr 
            740                 745                 750         


Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro 
        755                 760                 765     


<210>  219
<211>  1260
<212>  DNA
<213>  Homo sapiens

<400>  219
atgattggca cagatcctcg aacaattctt aaagatttat tgccggaaac aatacctcca       60

cctgagttgg atgatatgac actgtggcag attgttatta atatcctttc agaaccacca      120

aaaaggaaaa aaagaaaaga tattaataca attgaagatg ctgtgaaatt actgcaagag      180

tgcaaaaaaa ttatagttct aactggagct ggggtgtctg tttcatgtgg aatacctgac      240

ttcaggtcaa gggatggtat ttatgctcgc cttgctgtag acttcccaga tcttccagat      300

cctcaagcga tgtttgatat tgaatatttc agaaaagatc caagaccatt cttcaagttt      360

gcaaaggaaa tatatcctgg acaattccag ccatctctct gtcacaaatt catagccttg      420

tcagataagg aaggaaaact acttcgcaac tatacccaga acatagacac gctggaacag      480

gttgcgggaa tccaaaggat aattcagtgt catggttcct ttgcaacagc atcttgcctg      540

atttgtaaat acaaagttga ctgtgaagct gtacgaggag ctctttttag tcaggtagtt      600

cctcgatgtc ctaggtgccc agctgatgaa ccgcttgcta tcatgaaacc agagattgtg      660

ttttttggtg aaaatttacc agaacagttt catagagcca tgaagtatga caaagatgaa      720

gttgacctcc tcattgttat tgggtcttcc ctcaaagtaa gaccagtagc actaattcca      780

agttccatac cccatgaagt gcctcagata ttaattaata gagaaccttt gcctcatctg      840

cattttgatg tagagcttct tggagactgt gatgtcataa ttaatgaatt gtgtcatagg      900

ttaggtggtg aatatgccaa actttgctgt aaccctgtaa agctttcaga aattactgaa      960

aaacctccac gaacacaaaa agaattggct tatttgtcag agttgccacc cacacctctt     1020

catgtttcag aagactcaag ttcaccagaa agaacttcac caccagattc ttcagtgatt     1080

gtcacacttt tagaccaagc agctaagagt aatgatgatt tagatgtgtc tgaatcaaaa     1140

ggttgtatgg aagaaaaacc acaggaagta caaacttcta ggaatgttga aagtattgct     1200

gaacagatgg aaaatccgga tttgaagaat gttggttcta gtactgggga gaaaaatgaa     1260


<210>  220
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 
1               5                   10                  15      


Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 
            20                  25                  30          


Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 
        35                  40                  45              


Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 
    50                  55                  60                  


Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 
65                  70                  75                  80  


Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 
                85                  90                  95      


Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 
            100                 105                 110         


Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 
        115                 120                 125             


Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 
    130                 135                 140                 


Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 
145                 150                 155                 160 


Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 
                165                 170                 175     


Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 
            180                 185                 190         


Gly Ala Leu Phe Ser Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 
        195                 200                 205             


Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 
    210                 215                 220                 


Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 
225                 230                 235                 240 


Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 
                245                 250                 255     


Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 
            260                 265                 270         


Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 
        275                 280                 285             


Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 
    290                 295                 300                 


Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 
305                 310                 315                 320 


Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro 
                325                 330                 335     


Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 
            340                 345                 350         


Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala 
        355                 360                 365             


Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu 
    370                 375                 380                 


Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala 
385                 390                 395                 400 


Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly 
                405                 410                 415     


Glu Lys Asn Glu 
            420 


<210>  221
<211>  7341
<212>  DNA
<213>  Homo sapiens

<400>  221
gcgcgaggcc gtcgattcgc tcgcggctcc atcgcggcct ggccgggggg cggtgtctgc       60

tgcgccaggt tcgctggccg cacgtcttca ggtcctcctg ttcctgggag gcgggcgcgg      120

caggactggg aggtggcggc agcgggcgag gactcgccga ggacggggct ccggcccggg      180

ataaccaact ctccttctct cttctttggt gcttccccag gcggcggcgg cggcgcccgg      240

gagccggagc cttcgcggcg tccacgtccc tcccccgctg caccccgccc cggcgcgaga      300

ggagagcgcg agagccccag ccgcgggcgg gcgggcggcg aagatggcag aggcaccggc      360

ttccccggcc ccgctctctc cgctcgaagt ggagctggac ccggagttcg agccccagag      420

ccgtccgcga tcctgtacgt ggcccctgca aaggccggag ctccaagcga gccctgccaa      480

gccctcgggg gagacggccg ccgactccat gatccccgag gaggaggacg atgaagacga      540

cgaggacggc gggggacggg ccggctcggc catggcgatc ggcggcggcg gcgggagcgg      600

cacgctgggc tccgggctgc tccttgagga ctcggcccgg gtgctggcac ccggagggca      660

agaccccggg tctgggccag ccaccgcggc gggcgggctg agcgggggta cacaggcgct      720

gctgcagcct cagcaaccgc tgccaccgcc gcagccgggg gcggctgggg gctccgggca      780

gccgaggaaa tgttcgtcgc ggcggaacgc ctggggaaac ctgtcctacg cggacctgat      840

cacccgcgcc atcgagagct ccccggacaa acggctcact ctgtcccaga tctacgagtg      900

gatggtgcgt tgcgtgccct acttcaagga taagggcgac agcaacagct ctgccggctg      960

gaagaactcc atccggcaca acctgtcact gcatagtcga ttcatgcggg tccagaatga     1020

gggaactggc aagagctctt ggtggatcat caaccctgat ggggggaaga gcggaaaagc     1080

cccccggcgg cgggctgtct ccatggacaa tagcaacaag tataccaaga gccgtggccg     1140

cgcagccaag aagaaggcag ccctgcagac agcccccgaa tcagctgacg acagtccctc     1200

ccagctctcc aagtggcctg gcagccccac gtcacgcagc agtgatgagc tggatgcgtg     1260

gacggacttc cgttcacgca ccaattctaa cgccagcaca gtcagtggcc gcctgtcgcc     1320

catcatggca agcacagagt tggatgaagt ccaggacgat gatgcgcctc tctcgcccat     1380

gctctacagc agctcagcca gcctgtcacc ttcagtaagc aagccgtgca cggtggaact     1440

gccacggctg actgatatgg caggcaccat gaatctgaat gatgggctga ctgaaaacct     1500

catggacgac ctgctggata acatcacgct cccgccatcc cagccatcgc ccactggggg     1560

actcatgcag cggagctcta gcttcccgta taccaccaag ggctcgggcc tgggctcccc     1620

aaccagctcc tttaacagca cggtgttcgg accttcatct ctgaactccc tacgccagtc     1680

tcccatgcag accatccaag agaacaagcc agctaccttc tcttccatgt cacactatgg     1740

taaccagaca ctccaggacc tgctcacttc ggactcactt agccacagcg atgtcatgat     1800

gacacagtcg gaccccttga tgtctcaggc cagcaccgct gtgtctgccc agaattcccg     1860

ccggaacgtg atgcttcgca atgatccgat gatgtccttt gctgcccagc ctaaccaggg     1920

aagtttggtc aatcagaact tgctccacca ccagcaccaa acccagggcg ctcttggtgg     1980

cagccgtgcc ttgtcgaatt ctgtcagcaa catgggcttg agtgagtcca gcagccttgg     2040

gtcagccaaa caccagcagc agtctcctgt cagccagtct atgcaaaccc tctcggactc     2100

tctctcaggc tcctccttgt actcaactag tgcaaacctg cccgtcatgg gccatgagaa     2160

gttccccagc gacttggacc tggacatgtt caatgggagc ttggaatgtg acatggagtc     2220

cattatccgt agtgaactca tggatgctga tgggttggat tttaactttg attccctcat     2280

ctccacacag aatgttgttg gtttgaacgt ggggaacttc actggtgcta agcaggcctc     2340

atctcagagc tgggtgccag gctgaaggat cactgaggaa ggggaagtgg gcaaagcaga     2400

ccctcaaact gacacaagac ctacagagaa aaccctttgc caaatctgct ctcagcaagt     2460

ggacagtgat accgtttaca gcttaacacc tttgtgaatc ccacgccatt ttcctaaccc     2520

agcagagact gttaatggcc ccttaccctg ggtgaagcac ttacccttgg aacagaactc     2580

taaaaagtat gcaaaatctt ccttgtacag ggtggtgagc cgcctgccag tggaggacag     2640

cacccctcag caccacccac cctcattcag agcacaccgt gagcccccgt cggccattct     2700

gtggtgtttt aatattgcga tggtttatgg gacgttttaa gtgttgttct tgtgtttgtt     2760

ttcctttgac tttctgagtt tttcacatgc attaacttgc ggtatttttc tgttaaaatg     2820

ttaaccgtcc ttcccctagc aaatttaaaa acagaaagaa aatgttgtac cagttaccat     2880

tccgggttcg agcatcacaa gcttttgagc gcatggaact ccataaacta acaaattaca     2940

taaactaaag ggggattttc tttcttcttt tgtttggtag aaaattatcc ttttctaaaa     3000

actgaacaat ggcacaattg tttgctatgt gcacccgtcc aggacagaac cgtgcatagg     3060

caaaaggagt ggagcacagc gtccggccca gtgtgtttcc ggttctgagt cagggtgatc     3120

tgtggacggg accccagcac caagtctacg ggtgccagat cagtagggcc tgtgatttcc     3180

tgtcagtgtc ctcagctaat gtgaacagtg ttggtctgct ggttagaaac tagaatattg     3240

atattttcag gaaagaaatc agctcagctc tccactcatt gccaaatgtc actaaagggt     3300

ttagttttaa ggagaaagaa aaggaaaaaa aaaaaaaaca aaaaagtcct gttttgcttt     3360

gcagaacaaa tgaacttaca ggtgagcatt aagcttgcag tgagaaatgt gcgaagagta     3420

aaaacccaag tcaatgctga ggcagttcta acttcactgt tttcctaaat acacatcctt     3480

gattattttc agccttgcta tataatctga tctgctagaa gtgtatgagt gagaggcaat     3540

agcatacaaa ctgatttttt aaatataagc ttaggttgta attgtacaag tgactcaatg     3600

gaagtacaaa atagggcagt tttaactttt ttttctgctt ctatggattt cattttgttg     3660

tgttttcaaa aagttatggt gctgtatagg tgctttctgt ttaacctgga aagtgtgatt     3720

atattcgtta ccttctttgg tagacggaat agttgggacc acctttggta cataagaaat     3780

tggtataacg atgctctgat tagcacagta tatgcatact tctccaaagt gatatatgaa     3840

gactcttttc tttgcataaa aagcattagg catataaatg tataaatata ttttatcatg     3900

tacagtacaa aaatggaacc ttatgcatgg gccttaggaa tacaggctag tatttcagca     3960

cagacttccc tgcttgagtt cttgctgatg cttgcaccgt gacagtgggc accaacacag     4020

acgtgccacc caaccccctg cacacaccac cggccaccag gggccccctt gtgcgccttg     4080

gctttataac tcctctgggg gtgatattgg tggtgatcac agctcctagc ataatgagag     4140

ttccatttgg tattgtcaca cgtctcctgc ctcgcttggg ttgccatgtt tgagcgatgg     4200

ccctgttgat ttcaccctgc cttttactga atctgtaaat tgttgtgcaa ttgtggttat     4260

agtagactgt agcacattgc cttttctaaa ctgctacatg tttataatct tcatttttaa     4320

agtatgtgta atttttttaa gtatgtattc tattcatatg gtctgcttgt cagtgagcca     4380

gacttgctta ctatattcct ttataataat gctagccact tcctggattc tttagtaatg     4440

tgctgtatgc aagaactttc cagtagcagt gaaggagggt tgcctctcca agcttcctaa     4500

gggatgctgc cctgtgtggg gatgcattgc agaggcacta gtagcatggg ggctagagtg     4560

gggagcgaga tgtaaaaggg tggggggata ggagaattcc agagtgcttc cagcattagg     4620

gtcctgagaa cttctgagtt cagagaaaca tgcaaagtga ctaacaaaat agctacttac     4680

ctttgcagtt ttacagaccc tgggagctgc tttgggagtg agaaaggcaa ccctccaatg     4740

tgtttcaact ttaaaatgtt gaattctttt cagacatggt atctcattta ttctcctttt     4800

ctagcgtttg ttgaatttca ggcagaatgt cttacagaat gtcctagaac cagattatca     4860

tttaatctga aacagctgag gaagggacag agaaggtaca agggcaaggc agcacaaaac     4920

agatcaggag aatgaagagg gaatgctttg gttttttgtt ttgttttgtt ttttcttttt     4980

caagtaacta aaacagcatc tacatgtaga gtgttgtgga gagctgagac cagggtaaag     5040

tcaagtgcag catcagtact gcgagaccca ccagcccctg gagagggtca gccgagaatc     5100

tggtagtgaa gcctgtctag ggtcccggca ccctcaccct cagccacctg cagagaggcc     5160

agggccccag agactagcct ggttctgaag tgggcagggg tgctgccaga gccctctgcc     5220

ccttatgttg agaccctgct ttcaggacag gccagccgtt ggccaccatg tcacattctg     5280

agtgagtgtc acaggtccct aacaataatt ttctgatctg gagcatatca gcagaatgct     5340

tagcctcaag gggcctggca gctgtaatgt ttgatttatg atgagaacta tccgaggcca     5400

cccttggcct ctaaataagc tgctctaggg agccgcctac tttttgatga gaaattagaa     5460

gagtacctaa tgttgaaaac atgacatgcg ctcttgggat ctgctgttct ctccagggct     5520

ccagaacctg atacctgtta ccaaagctag gaaagagctt tatcacaagc cttcactgtc     5580

ctggcatgag aactggctgc caggctcagt gtaccccatt aactgtgaat gaatctgagc     5640

ttggtttcct ttattgcttc ctctgcaata tgattgctga aacacatttt aaaaattcag     5700

aagcttgtca ctcctgttaa tgggaggatc agtcacacat gtgtagtaca aggcggactt     5760

tgtgtttgtt tttggtgtta atttttagca ttgtgtgtgt tgcttcccca ccctgaggag     5820

aggacaccat ggcttactac tcaggacaag tatgccccgc tcagggtgtg atttcaggtg     5880

gcttccaaac ttgtacgcag tttaaagatg gtggggacag actttgcctc tacctagtga     5940

accccactta aagaataagg agcatttgaa tctcttggaa aaggccatga agaataaagc     6000

agtcaaaaag aagtcctcca tgttggtgcc aaggacttgc gaggggaaat aaaaatgtta     6060

tccagcctga ccaacatgga gaaaccccgt ctccattaaa aatacaaaat tagcctggca     6120

tggtggcgca tgcctgtaat cccagctact ctggaggctg aggcaggaga atcgcttgaa     6180

cccaggaggc ggaggtcgca gtgagccgag atcatgccag tgcactccag cctgggtaac     6240

aagagtgaaa ctccgtgtca aaaaaaaaaa aaaaatgtta ctcatcctct ctgaaagcaa     6300

aaaggaaacc ctaacagctc tgaactctgg ttttattttt cttgctgtat ttgggtgaac     6360

attgtatgat taggcataat gttaaaaaaa aaaatttttt tttggtagaa atgcaatcac     6420

cagtaaagag gtacgaaaaa gctagcctct ctcagagacc ggggaggcag agtactacta     6480

gaggaagtga agttctgatg gaatcatgcc tgtcaaatga ggtcttgaag cggatgccca     6540

aataaaagag tatattttat ctaaatctta agtgggtaac attttatgca gtttaaatga     6600

atggaatatt ttcctcttgt ttagttgtat ctgtttgtat ttttctttga tgaatgattg     6660

gtcatgaggc ctcttgccac actccagaaa tacgtgtgcg gctgctttta agaactatgt     6720

gtctggtcac ttatttctct aaaattatct cattgcctgg caatcagtct tctcttgtat     6780

acttgtccta gcacattatg tacatgggaa atgtaaacaa atgtgaagga ggaccagaaa     6840

aattagttaa tatttaaaaa aatgtattgt gcattttggc ttcacatgtt taactttttt     6900

taagaaaaaa gttgcatgaa tggaaaaaaa aatctgtata cagtatctgt aaaaactatc     6960

ttatctgttt caattccttg ctcatatccc atataatcta gaactaaata tggtgtgtgg     7020

ccatatttaa acacctgaga gtcaagcagt tgagactttg atttgaagca cctcatcctt     7080

ctttcaatgc gaacactatc atatggcatt cttactgagg attttgtcta accatatgtt     7140

gccatgaatt aactctgccg cctttcttaa ggatcaaaac cagtttgatt tgggaatctt     7200

cccctttcca aatgaaatag agatgcagta cttaactttc cttggtgttt gtagatattg     7260

ccttgtgtat tccacttaaa accgtaatct agtttgtaaa agagatggtg acgcatgtaa     7320

ataaagcatc agtgacactc t                                               7341


<210>  222
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Ala Glu Ala Pro Ala Ser Pro Ala Pro Leu Ser Pro Leu Glu Val 
1               5                   10                  15      


Glu Leu Asp Pro Glu Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr 
            20                  25                  30          


Trp Pro Leu Gln Arg Pro Glu Leu Gln Ala Ser Pro Ala Lys Pro Ser 
        35                  40                  45              


Gly Glu Thr Ala Ala Asp Ser Met Ile Pro Glu Glu Glu Asp Asp Glu 
    50                  55                  60                  


Asp Asp Glu Asp Gly Gly Gly Arg Ala Gly Ser Ala Met Ala Ile Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Thr Leu Gly Ser Gly Leu Leu Leu Glu Asp 
                85                  90                  95      


Ser Ala Arg Val Leu Ala Pro Gly Gly Gln Asp Pro Gly Ser Gly Pro 
            100                 105                 110         


Ala Thr Ala Ala Gly Gly Leu Ser Gly Gly Thr Gln Ala Leu Leu Gln 
        115                 120                 125             


Pro Gln Gln Pro Leu Pro Pro Pro Gln Pro Gly Ala Ala Gly Gly Ser 
    130                 135                 140                 


Gly Gln Pro Arg Lys Cys Ser Ser Arg Arg Asn Ala Trp Gly Asn Leu 
145                 150                 155                 160 


Ser Tyr Ala Asp Leu Ile Thr Arg Ala Ile Glu Ser Ser Pro Asp Lys 
                165                 170                 175     


Arg Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Arg Cys Val Pro 
            180                 185                 190         


Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly Trp Lys Asn 
        195                 200                 205             


Ser Ile Arg His Asn Leu Ser Leu His Ser Arg Phe Met Arg Val Gln 
    210                 215                 220                 


Asn Glu Gly Thr Gly Lys Ser Ser Trp Trp Ile Ile Asn Pro Asp Gly 
225                 230                 235                 240 


Gly Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala Val Ser Met Asp Asn 
                245                 250                 255     


Ser Asn Lys Tyr Thr Lys Ser Arg Gly Arg Ala Ala Lys Lys Lys Ala 
            260                 265                 270         


Ala Leu Gln Thr Ala Pro Glu Ser Ala Asp Asp Ser Pro Ser Gln Leu 
        275                 280                 285             


Ser Lys Trp Pro Gly Ser Pro Thr Ser Arg Ser Ser Asp Glu Leu Asp 
    290                 295                 300                 


Ala Trp Thr Asp Phe Arg Ser Arg Thr Asn Ser Asn Ala Ser Thr Val 
305                 310                 315                 320 


Ser Gly Arg Leu Ser Pro Ile Met Ala Ser Thr Glu Leu Asp Glu Val 
                325                 330                 335     


Gln Asp Asp Asp Ala Pro Leu Ser Pro Met Leu Tyr Ser Ser Ser Ala 
            340                 345                 350         


Ser Leu Ser Pro Ser Val Ser Lys Pro Cys Thr Val Glu Leu Pro Arg 
        355                 360                 365             


Leu Thr Asp Met Ala Gly Thr Met Asn Leu Asn Asp Gly Leu Thr Glu 
    370                 375                 380                 


Asn Leu Met Asp Asp Leu Leu Asp Asn Ile Thr Leu Pro Pro Ser Gln 
385                 390                 395                 400 


Pro Ser Pro Thr Gly Gly Leu Met Gln Arg Ser Ser Ser Phe Pro Tyr 
                405                 410                 415     


Thr Thr Lys Gly Ser Gly Leu Gly Ser Pro Thr Ser Ser Phe Asn Ser 
            420                 425                 430         


Thr Val Phe Gly Pro Ser Ser Leu Asn Ser Leu Arg Gln Ser Pro Met 
        435                 440                 445             


Gln Thr Ile Gln Glu Asn Lys Pro Ala Thr Phe Ser Ser Met Ser His 
    450                 455                 460                 


Tyr Gly Asn Gln Thr Leu Gln Asp Leu Leu Thr Ser Asp Ser Leu Ser 
465                 470                 475                 480 


His Ser Asp Val Met Met Thr Gln Ser Asp Pro Leu Met Ser Gln Ala 
                485                 490                 495     


Ser Thr Ala Val Ser Ala Gln Asn Ser Arg Arg Asn Val Met Leu Arg 
            500                 505                 510         


Asn Asp Pro Met Met Ser Phe Ala Ala Gln Pro Asn Gln Gly Ser Leu 
        515                 520                 525             


Val Asn Gln Asn Leu Leu His His Gln His Gln Thr Gln Gly Ala Leu 
    530                 535                 540                 


Gly Gly Ser Arg Ala Leu Ser Asn Ser Val Ser Asn Met Gly Leu Ser 
545                 550                 555                 560 


Glu Ser Ser Ser Leu Gly Ser Ala Lys His Gln Gln Gln Ser Pro Val 
                565                 570                 575     


Ser Gln Ser Met Gln Thr Leu Ser Asp Ser Leu Ser Gly Ser Ser Leu 
            580                 585                 590         


Tyr Ser Thr Ser Ala Asn Leu Pro Val Met Gly His Glu Lys Phe Pro 
        595                 600                 605             


Ser Asp Leu Asp Leu Asp Met Phe Asn Gly Ser Leu Glu Cys Asp Met 
    610                 615                 620                 


Glu Ser Ile Ile Arg Ser Glu Leu Met Asp Ala Asp Gly Leu Asp Phe 
625                 630                 635                 640 


Asn Phe Asp Ser Leu Ile Ser Thr Gln Asn Val Val Gly Leu Asn Val 
                645                 650                 655     


Gly Asn Phe Thr Gly Ala Lys Gln Ala Ser Ser Gln Ser Trp Val Pro 
            660                 665                 670         


Gly 
    


<210>  223
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  223
tggctcagtt cagcaggaac ag                                                22


<210>  224
<211>  86
<212>  DNA
<213>  Homo sapiens

<400>  224
tgccagtctc taggtccctg agacccttta acctgtgagg acatccaggg tcacaggtga       60

ggttcttggg agcctggcgt ctggcc                                            86


<210>  225
<211>  110
<212>  DNA
<213>  Homo sapiens

<400>  225
gtgttgggga ctcgcgcgct gggtccagtg gttcttaaca gttcaacagt tctgtagcgc       60

aattgtgaaa tgtttaggac cactagaccc ggcgggcgcg gcgacagcga                 110


<210>  226
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  226
tgtgtctctc tctgtgtcct gccagtggtt ttaccctatg gtaggttacg tcatgctgtt       60

ctaccacagg gtagaaccac ggacaggata ccggggcacc                            100


<210>  227
<211>  78
<212>  DNA
<213>  Homo sapiens

<400>  227
ctgaggagca gggcttagct gcttgtgagc agggtccaca ccaagtcgtg ttcacagtgg       60

ctaagttccg ccccccag                                                     78


