                         SEQUENCE LISTING

<110>  The Provost, Fellows, Foundation Scholars, & the other 
       members of Board, of the College of the Holy & Undivided Trinity 
       of Queen Elizabeth near Dublin
 
<120>  TOLL-LIKE RECEPTOR 2 AGONISTS AND VACCINES AND USES THEREOF

<130>  P165630.WO.01

<150>  EP14160791.1
<151>  2014-03-19

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  375
<212>  PRT
<213>  Bordetella pertussis

<400>  1

Met Arg Met Asn Lys Arg His Ala Gly Ala Ser Ala Leu Met Ala Leu 
1               5                   10                  15      


Ala Leu Leu Ala Gly Cys Ser Asp Val Asn Gln Leu Leu Gly Asn Glu 
            20                  25                  30          


Glu Ser Val Asp Tyr Lys Ser Thr Arg Arg Gly Asp Pro Leu Ser Ile 
        35                  40                  45              


Pro Pro Asp Leu Thr Gln Ala Asn Asn Asp Pro Arg Tyr Lys Ala Pro 
    50                  55                  60                  


Ala Ser Gly Thr Ala Thr Tyr Ser Gln Phe Gln Gln Gln Gly Leu Gln 
65                  70                  75                  80  


Gln Gln Ala Ser Ala Gly Gln Asn Thr Asn Val Leu Pro Glu Arg Ala 
                85                  90                  95      


Asp Met Arg Val Glu Arg Asp Gly Asp Leu Arg Trp Leu Val Ile Glu 
            100                 105                 110         


Arg Pro Pro Glu Gln Leu Phe Ser Lys Val Val Asp Phe Trp Thr Asp 
        115                 120                 125             


Thr Gly Phe Thr Val Ser Val Asn Asn Pro Gln Ala Gly Ile Ile Glu 
    130                 135                 140                 


Thr Asp Trp Ala Glu Asn Arg Ala Lys Ile Pro Glu Ser Trp Leu Arg 
145                 150                 155                 160 


Gln Val Leu Gly Ser Val Leu Glu Thr Ala Trp Asp Ser Gly Glu Arg 
                165                 170                 175     


Glu Lys Phe Arg Thr Arg Val Glu Arg Val Asn Gly His Thr Glu Ile 
            180                 185                 190         


Tyr Ile Thr His Asn Gln Met Leu Glu Lys Arg Val Gly Ser Asp Gly 
        195                 200                 205             


Gly Gln Val Gln Trp Thr His Gly Lys Glu Asp Pro Gly Leu Asn Ala 
    210                 215                 220                 


Ala Met Leu Ala Arg Leu Met Val Tyr Leu Gly Thr Asp Val Asp Ala 
225                 230                 235                 240 


Ala Arg Lys Leu Val Ala Gln Ala Glu Ala Ala Pro Gln Ala Pro Lys 
                245                 250                 255     


Val Gln Ser Val Arg Ala Glu Gly Ala Met Leu Val Val Asp Glu Ser 
            260                 265                 270         


Phe Asp Arg Ala Trp Arg Arg Val Gly Val Ala Leu Asp Ser Gly Gly 
        275                 280                 285             


Phe Ala Val Asp Asp Arg Asp Arg Ser Ala Gly Glu Tyr Phe Val Arg 
    290                 295                 300                 


Tyr Val Asp Thr Asp Thr Gly Ala Gln Asn Glu Gln Pro Gly Phe Phe 
305                 310                 315                 320 


Ser Arg Leu Phe Ser Ser Asp Lys Lys Ala Gln Ala Pro Gln Tyr Arg 
                325                 330                 335     


Ile Arg Leu Thr Gly Ser Gly Thr Gln Thr Gln Val Thr Val Leu Asp 
            340                 345                 350         


Ala Asn Gly Gln Arg Asp Ser Ser Ala Thr Ala Gln Arg Met Leu Ser 
        355                 360                 365             


Val Leu Lys Asp Lys Met Val 
    370                 375 


<210>  2
<211>  166
<212>  PRT
<213>  Bordetella pertussis

<400>  2

Asn Tyr Met His Ser Pro Ser Val Val Ala Gly Arg Ala Arg Arg Leu 
1               5                   10                  15      


Leu Ala Val Ala Ala Val Ala Gly Ser Val Ala Val Leu Ala Gly Cys 
            20                  25                  30          


Ala Asn Pro Ser Ala Ser Ser Gly Val Tyr Thr Tyr Gly Gln Ala Gln 
        35                  40                  45              


Arg Glu Gln Ile Val Arg Thr Gly Thr Val Thr Gly Val Arg Pro Ile 
    50                  55                  60                  


Thr Ile Gln Asn Asp Lys Ser Ser Gly Val Gly Leu Val Ala Gly Gly 
65                  70                  75                  80  


Ala Leu Gly Gly Val Ala Gly Asn Ala Val Gly Gly Gly Thr Gly Arg 
                85                  90                  95      


Thr Ile Ala Thr Val Gly Gly Val Ile Leu Gly Ala Leu Ala Gly Asn 
            100                 105                 110         


Ala Ile Glu Asn Arg Ala Gly Lys Ser Ser Gly Tyr Glu Ile Thr Val 
        115                 120                 125             


Arg Leu Asp Asn Gly Glu Thr Arg Val Val Ala Gln Glu Ala Asp Val 
    130                 135                 140                 


Pro Ile Ser Val Gly Gln Arg Val Gln Val Ile Ser Gly Ala Gly Pro 
145                 150                 155                 160 


Thr Arg Val Thr Pro Tyr 
                165     


<210>  3
<211>  188
<212>  PRT
<213>  Bordetella pertussis

<400>  3

Met Gln Leu Thr Ile Arg Lys Leu Ala Tyr Thr Leu Ala Phe Ser Thr 
1               5                   10                  15      


Leu Val Leu Ala Gly Cys Thr Thr Ala Ser Lys Lys Thr Asp Gly Gln 
            20                  25                  30          


Ala Ala Thr Pro Ala Asp Gln Ala Ser Ser Gln Gln Ala Ser Ala Ala 
        35                  40                  45              


Ser Val Glu Phe Tyr Val Ala Gln Ala Lys Ala Gly Asp Gly Leu Met 
    50                  55                  60                  


Glu Val Lys Val Pro Asp Gly Ser Leu Tyr Met Gln Arg Gln Pro Val 
65                  70                  75                  80  


Leu Thr Arg Ala Asp Leu Thr Glu Ala Ala Ala Leu Val Asp Arg Gln 
                85                  90                  95      


Gly Gln Asn Phe Val Gly Leu Arg Phe Thr Glu Ala Gly Ala Arg Lys 
            100                 105                 110         


Leu Asn Asp Ile Ser Ser Lys Asn Ile Gly Asn Met Leu Ala Leu Val 
        115                 120                 125             


Ile Asp Arg Glu Leu Val Ala Ala Pro Arg Ile Ala Glu Pro Leu Asn 
    130                 135                 140                 


Arg Gly Val Leu Ala Phe Gly Val Pro Ser Ala Lys Ala Ala Ser Glu 
145                 150                 155                 160 


Ile Ala Ala Lys Ile Arg Gly Asp Ala Gly Ala Pro Ala Ala Gly Val 
                165                 170                 175     


Pro Ala Ala Pro Ala Pro Lys Pro Ala Pro Lys Pro 
            180                 185             


<210>  4
<211>  165
<212>  PRT
<213>  Bordetella pertussis

<400>  4

Met Lys Ser Arg Ile Ala Lys Ser Leu Thr Ile Ala Ala Leu Ala Ala 
1               5                   10                  15      


Thr Leu Ala Ala Cys Ser Ser Val Pro Leu Asp Asp Lys Ala Gly Gln 
            20                  25                  30          


Ala Gly Gly Ser Gly Gln Gly Ser Ala Ser Gly Gln Ile Leu Asp Pro 
        35                  40                  45              


Phe Asn Pro Gln Ser Ile Leu Ala Gln Gln Arg Ser Val Tyr Phe Asp 
    50                  55                  60                  


Phe Asp Ser Tyr Thr Val Ser Glu Gln Tyr Arg Gly Leu Val Glu Thr 
65                  70                  75                  80  


His Ala Arg Tyr Leu Ala Ser Asn Asn Gln Gln Arg Ile Lys Ile Glu 
                85                  90                  95      


Gly Asn Thr Asp Glu Arg Gly Gly Ala Glu Tyr Asn Leu Ala Leu Gly 
            100                 105                 110         


Gln Arg Arg Ala Asp Ala Val Arg Arg Met Met Thr Leu Leu Gly Val 
        115                 120                 125             


Ser Asp Asn Gln Ile Glu Thr Ile Ser Phe Gly Lys Glu Lys Pro Lys 
    130                 135                 140                 


Ala Thr Gly Ser Ser Glu Ala Asp Phe Ala Glu Asn Arg Arg Ala Asp 
145                 150                 155                 160 


Ile Val Tyr Gln Arg 
                165 


<210>  5
<211>  247
<212>  PRT
<213>  Bordetella pertussis

<400>  5

Met Ser Ala Pro Leu Asp Thr Pro Ala Leu Arg Leu Asn Thr Arg Phe 
1               5                   10                  15      


Ala Thr Gly Ile Val Leu Ala Gly Thr Leu Ala Leu Ala Gly Cys Ala 
            20                  25                  30          


Gln Gln Arg Ser Ala Gly Tyr Tyr Asp Pro Pro Gly Ala Ser Thr Ile 
        35                  40                  45              


Thr Asp Ala Gln Tyr Gln Gly Gln Ala Ala Gly Tyr Arg Thr Val Val 
    50                  55                  60                  


His Ala Pro Ser Gln Leu Gln Ile Glu Leu Lys Pro Asn Gln Pro Ala 
65                  70                  75                  80  


Arg Gln Gln Asn Ala Gln Ala Gln Ala Gly Gln Gln Ser Thr Glu Asp 
                85                  90                  95      


Gly Thr Ala Val Pro Glu Gly Gln Ala Ala Pro Gln Pro Gln Pro Glu 
            100                 105                 110         


Thr Ala Ser Pro Gly Ala Gln Ala Ile Ile Pro Gln Ala Gln Thr Tyr 
        115                 120                 125             


Gln Gly Thr Phe Pro Cys Phe Ala Ala Gly Leu Ala Cys Glu Ala Gln 
    130                 135                 140                 


Arg Val Thr Leu Thr Leu Ala Pro Asn Gly Arg Trp Arg Ser Arg Thr 
145                 150                 155                 160 


Asn Tyr Leu Asp Lys Gln Pro Gln Ala Ser Ala Pro Val Ala Glu Gln 
                165                 170                 175     


Gly Cys Trp Asp Ala Thr Gln Glu Arg Pro Pro Arg Val Leu Leu Leu 
            180                 185                 190         


Asp Gly Ser Gly Asn Met Arg Ala Glu Leu Val Met Thr Ala Asn Asn 
        195                 200                 205             


Val Leu Arg Val Arg Ser Val Gly Gly Arg Thr Pro Asn Leu Asn Tyr 
    210                 215                 220                 


Asn Leu Thr Arg Gln Pro Asp Leu Asp Ala Ile Ala Glu Leu Asp Lys 
225                 230                 235                 240 


Gln Ala Ala Pro Lys Cys Pro 
                245         


<210>  6
<211>  182
<212>  PRT
<213>  Bordetella pertussis

<400>  6

Met Ile Ala Arg Ile Ser Leu Arg Pro Leu Lys Gly Leu Ala Val Ala 
1               5                   10                  15      


Val Leu Ala Ala Ser Ala Leu Thr Ala Cys Ser Ser Gly Lys Trp Gly 
            20                  25                  30          


Phe Pro Tyr Lys Ala Gly Val Gln Gln Gly Asn Trp Ile Thr Lys Glu 
        35                  40                  45              


Gln Val Ala Leu Leu Gln Gln Gly Met Ser Arg Glu Gln Val Arg Phe 
    50                  55                  60                  


Ala Leu Gly Ser Pro Thr Leu Thr Ser Val Leu His Ala Asp Arg Trp 
65                  70                  75                  80  


Asp Tyr Pro Tyr Tyr Phe Lys Pro Gly Tyr Gly Lys Ala Gln Glu Arg 
                85                  90                  95      


Gln Phe Thr Val Trp Phe Glu Asn Asp His Leu Val Arg Trp Ser Gly 
            100                 105                 110         


Asp Glu Gln Pro Asp Leu Gln Pro Phe Gln Ile Glu Lys Val Asn Ala 
        115                 120                 125             


Lys Gln Glu Glu Lys Ala Asp Ala Gln Val Asp Thr Ala Glu Lys Arg 
    130                 135                 140                 


Gln Glu Gly Ile Asp Lys Ala Glu Lys Val Arg Pro His Val Asp Val 
145                 150                 155                 160 


Thr Thr Pro Asp Asn Pro Thr Leu Asp Tyr Pro Gly Glu Pro Gly Gln 
                165                 170                 175     


Thr Phe Glu Pro Leu Lys 
            180         


<210>  7
<211>  22
<212>  PRT
<213>  Bordetella pertussis

<400>  7

Met Arg Met Asn Lys Arg His Ala Gly Ala Ser Ala Leu Met Ala Leu 
1               5                   10                  15      


Ala Leu Leu Ala Gly Cys 
            20          


<210>  8
<211>  33
<212>  PRT
<213>  Bordetella pertussis

<400>  8

Met Asn Tyr Met His Ser Pro Ser Val Val Ala Gly Arg Ala Arg Arg 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Gly Ser Val Ala Val Leu Ala Gly 
            20                  25                  30          


Cys 
    


<210>  9
<211>  22
<212>  PRT
<213>  Bordetella pertussis

<400>  9

Met Gln Leu Thr Ile Arg Lys Leu Ala Tyr Thr Leu Ala Phe Ser Thr 
1               5                   10                  15      


Leu Val Leu Ala Gly Cys 
            20          


<210>  10
<211>  21
<212>  PRT
<213>  Bordetella pertussis

<400>  10

Met Lys Ser Arg Ile Ala Lys Ser Leu Thr Ile Ala Ala Leu Ala Ala 
1               5                   10                  15      


Thr Leu Ala Ala Cys 
            20      


<210>  11
<211>  31
<212>  PRT
<213>  Bordetella pertussis

<400>  11

Met Ser Ala Pro Leu Asp Thr Pro Ala Leu Arg Leu Asn Thr Arg Phe 
1               5                   10                  15      


Ala Thr Gly Ile Val Leu Ala Gly Thr Leu Ala Leu Ala Gly Cys 
            20                  25                  30      


<210>  12
<211>  26
<212>  PRT
<213>  Bordetella pertussis

<400>  12

Met Ile Ala Arg Ile Ser Leu Arg Pro Leu Lys Gly Leu Ala Val Ala 
1               5                   10                  15      


Val Leu Ala Ala Ser Ala Leu Thr Ala Cys 
            20                  25      


<210>  13
<211>  15
<212>  PRT
<213>  Bordetella pertussis

<400>  13

Cys Ser Asp Val Asn Gln Leu Leu Gly Asn Glu Glu Ser Val Asp 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Bordetella pertussis

<400>  14

Cys Ala Asn Pro Ser Ala Ser Ser Gly Val Tyr Thr Tyr Gly Gln 
1               5                   10                  15  


