﻿               SEQUENCE LISTING

<110> Université de Technologie de Compiègne
      Centre national de la recherche scientifique

<120> INHIBITEURS DE STAT5 ET UTILISATION DE CEUX-CI

<130> CV - 348/PCT

<160> 84

<170> BiSSAP 1.2

<210> 1
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..60
<223> /mol_type="unassigned DNA"
      /note="Aptamère Apta 1"
      /organism="Artificial Sequence"

<400> 1
tatccgcaac ccacctagcg ccctacctcg tgggaatcca aacccaacca gtccacccac     60


<210> 2
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..60
<223> /mol_type="unassigned DNA"
      /note="Aptamère Apta 2"
      /organism="Artificial Sequence"

<400> 2
gtgtctgttc actcgtcgat acacagcata ctcaacccag gcccctgact gctaatcccc     60


<210> 3
<211> 96
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..96
<223> /mol_type="unassigned DNA"
      /note="Aptamère Apta 1 et séquences flanquantes"
      /organism="Artificial Sequence"

<400> 3
ataccagctt attcaattta tccgcaaccc acctagcgcc ctacctcgtg ggaatccaaa     60

cccaaccagt ccacccacag atagtaagtg caatct                               96


<210> 4
<211> 96
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..96
<223> /mol_type="unassigned DNA"
      /note="Aptamère Apta 2 et séquences flanquantes"
      /organism="Artificial Sequence"

<400> 4
ataccagctt attcaattgt gtctgttcac tcgtcgatac acagcatact caacccaggc     60

ccctgactgc taatccccag atagtaagtg caatct                               96


<210> 5
<211> 794
<212> PRT
<213> Homo sapiens

<220> 
<223> STAT5A

<400> 5
Met Ala Gly Trp Ile Gln Ala Gln Gln Leu Gln Gly Asp Ala Leu Arg 
1               5                   10                  15      
Gln Met Gln Val Leu Tyr Gly Gln His Phe Pro Ile Glu Val Arg His 
            20                  25                  30          
Tyr Leu Ala Gln Trp Ile Glu Ser Gln Pro Trp Asp Ala Ile Asp Leu 
        35                  40                  45              
Asp Asn Pro Gln Asp Arg Ala Gln Ala Thr Gln Leu Leu Glu Gly Leu 
    50                  55                  60                  
Val Gln Glu Leu Gln Lys Lys Ala Glu His Gln Val Gly Glu Asp Gly 
65                  70                  75                  80  
Phe Leu Leu Lys Ile Lys Leu Gly His Tyr Ala Thr Gln Leu Gln Lys 
                85                  90                  95      
Thr Tyr Asp Arg Cys Pro Leu Glu Leu Val Arg Cys Ile Arg His Ile 
            100                 105                 110         
Leu Tyr Asn Glu Gln Arg Leu Val Arg Glu Ala Asn Asn Cys Ser Ser 
        115                 120                 125             
Pro Ala Gly Ile Leu Val Asp Ala Met Ser Gln Lys His Leu Gln Ile 
    130                 135                 140                 
Asn Gln Thr Phe Glu Glu Leu Arg Leu Val Thr Gln Asp Thr Glu Asn 
145                 150                 155                 160 
Glu Leu Lys Lys Leu Gln Gln Thr Gln Glu Tyr Phe Ile Ile Gln Tyr 
                165                 170                 175     
Gln Glu Ser Leu Arg Ile Gln Ala Gln Phe Ala Gln Leu Ala Gln Leu 
            180                 185                 190         
Ser Pro Gln Glu Arg Leu Ser Arg Glu Thr Ala Leu Gln Gln Lys Gln 
        195                 200                 205             
Val Ser Leu Glu Ala Trp Leu Gln Arg Glu Ala Gln Thr Leu Gln Gln 
    210                 215                 220                 
Tyr Arg Val Glu Leu Ala Glu Lys His Gln Lys Thr Leu Gln Leu Leu 
225                 230                 235                 240 
Arg Lys Gln Gln Thr Ile Ile Leu Asp Asp Glu Leu Ile Gln Trp Lys 
                245                 250                 255     
Arg Arg Gln Gln Leu Ala Gly Asn Gly Gly Pro Pro Glu Gly Ser Leu 
            260                 265                 270         
Asp Val Leu Gln Ser Trp Cys Glu Lys Leu Ala Glu Ile Ile Trp Gln 
        275                 280                 285             
Asn Arg Gln Gln Ile Arg Arg Ala Glu His Leu Cys Gln Gln Leu Pro 
    290                 295                 300                 
Ile Pro Gly Pro Val Glu Glu Met Leu Ala Glu Val Asn Ala Thr Ile 
305                 310                 315                 320 
Thr Asp Ile Ile Ser Ala Leu Val Thr Ser Thr Phe Ile Ile Glu Lys 
                325                 330                 335     
Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys Phe Ala Ala Thr Val 
            340                 345                 350         
Arg Leu Leu Val Gly Gly Lys Leu Asn Val His Met Asn Pro Pro Gln 
        355                 360                 365             
Val Lys Ala Thr Ile Ile Ser Glu Gln Gln Ala Lys Ser Leu Leu Lys 
    370                 375                 380                 
Asn Glu Asn Thr Arg Asn Glu Cys Ser Gly Glu Ile Leu Asn Asn Cys 
385                 390                 395                 400 
Cys Val Met Glu Tyr His Gln Ala Thr Gly Thr Leu Ser Ala His Phe 
                405                 410                 415     
Arg Asn Met Ser Leu Lys Arg Ile Lys Arg Ala Asp Arg Arg Gly Ala 
            420                 425                 430         
Glu Ser Val Thr Glu Glu Lys Phe Thr Val Leu Phe Glu Ser Gln Phe 
        435                 440                 445             
Ser Val Gly Ser Asn Glu Leu Val Phe Gln Val Lys Thr Leu Ser Leu 
    450                 455                 460                 
Pro Val Val Val Ile Val His Gly Ser Gln Asp His Asn Ala Thr Ala 
465                 470                 475                 480 
Thr Val Leu Trp Asp Asn Ala Phe Ala Glu Pro Gly Arg Val Pro Phe 
                485                 490                 495     
Ala Val Pro Asp Lys Val Leu Trp Pro Gln Leu Cys Glu Ala Leu Asn 
            500                 505                 510         
Met Lys Phe Lys Ala Glu Val Gln Ser Asn Arg Gly Leu Thr Lys Glu 
        515                 520                 525             
Asn Leu Val Phe Leu Ala Gln Lys Leu Phe Asn Asn Ser Ser Ser His 
    530                 535                 540                 
Leu Glu Asp Tyr Ser Gly Leu Ser Val Ser Trp Ser Gln Phe Asn Arg 
545                 550                 555                 560 
Glu Asn Leu Pro Gly Trp Asn Tyr Thr Phe Trp Gln Trp Phe Asp Gly 
                565                 570                 575     
Val Met Glu Val Leu Lys Lys His His Lys Pro His Trp Asn Asp Gly 
            580                 585                 590         
Ala Ile Leu Gly Phe Val Asn Lys Gln Gln Ala His Asp Leu Leu Ile 
        595                 600                 605             
Asn Lys Pro Asp Gly Thr Phe Leu Leu Arg Phe Ser Asp Ser Glu Ile 
    610                 615                 620                 
Gly Gly Ile Thr Ile Ala Trp Lys Phe Asp Ser Pro Glu Arg Asn Leu 
625                 630                 635                 640 
Trp Asn Leu Lys Pro Phe Thr Thr Arg Asp Phe Ser Ile Arg Ser Leu 
                645                 650                 655     
Ala Asp Arg Leu Gly Asp Leu Ser Tyr Leu Ile Tyr Val Phe Pro Asp 
            660                 665                 670         
Arg Pro Lys Asp Glu Val Phe Ser Lys Tyr Tyr Thr Pro Val Leu Ala 
        675                 680                 685             
Lys Ala Val Asp Gly Tyr Val Lys Pro Gln Ile Lys Gln Val Val Pro 
    690                 695                 700                 
Glu Phe Val Asn Ala Ser Ala Asp Ala Gly Gly Ser Ser Ala Thr Tyr 
705                 710                 715                 720 
Met Asp Gln Ala Pro Ser Pro Ala Val Cys Pro Gln Ala Pro Tyr Asn 
                725                 730                 735     
Met Tyr Pro Gln Asn Pro Asp His Val Leu Asp Gln Asp Gly Glu Phe 
            740                 745                 750         
Asp Leu Asp Glu Thr Met Asp Val Ala Arg His Val Glu Glu Leu Leu 
        755                 760                 765             
Arg Arg Pro Met Asp Ser Leu Asp Ser Arg Leu Ser Pro Pro Ala Gly 
    770                 775                 780                 
Leu Phe Thr Ser Ala Arg Gly Ser Leu Ser 
785                 790                 

<210> 6
<211> 787
<212> PRT
<213> Homo sapiens

<220> 
<223> STAT5B

<400> 6
Met Ala Val Trp Ile Gln Ala Gln Gln Leu Gln Gly Glu Ala Leu His 
1               5                   10                  15      
Gln Met Gln Ala Leu Tyr Gly Gln His Phe Pro Ile Glu Val Arg His 
            20                  25                  30          
Tyr Leu Ser Gln Trp Ile Glu Ser Gln Ala Trp Asp Ser Val Asp Leu 
        35                  40                  45              
Asp Asn Pro Gln Glu Asn Ile Lys Ala Thr Gln Leu Leu Glu Gly Leu 
    50                  55                  60                  
Val Gln Glu Leu Gln Lys Lys Ala Glu His Gln Val Gly Glu Asp Gly 
65                  70                  75                  80  
Phe Leu Leu Lys Ile Lys Leu Gly His Tyr Ala Thr Gln Leu Gln Asn 
                85                  90                  95      
Thr Tyr Asp Arg Cys Pro Met Glu Leu Val Arg Cys Ile Arg His Ile 
            100                 105                 110         
Leu Tyr Asn Glu Gln Arg Leu Val Arg Glu Ala Asn Asn Gly Ser Ser 
        115                 120                 125             
Pro Ala Gly Ser Leu Ala Asp Ala Met Ser Gln Lys His Leu Gln Ile 
    130                 135                 140                 
Asn Gln Thr Phe Glu Glu Leu Arg Leu Val Thr Gln Asp Thr Glu Asn 
145                 150                 155                 160 
Glu Leu Lys Lys Leu Gln Gln Thr Gln Glu Tyr Phe Ile Ile Gln Tyr 
                165                 170                 175     
Gln Glu Ser Leu Arg Ile Gln Ala Gln Phe Gly Pro Leu Ala Gln Leu 
            180                 185                 190         
Ser Pro Gln Glu Arg Leu Ser Arg Glu Thr Ala Leu Gln Gln Lys Gln 
        195                 200                 205             
Val Ser Leu Glu Ala Trp Leu Gln Arg Glu Ala Gln Thr Leu Gln Gln 
    210                 215                 220                 
Tyr Arg Val Glu Leu Ala Glu Lys His Gln Lys Thr Leu Gln Leu Leu 
225                 230                 235                 240 
Arg Lys Gln Gln Thr Ile Ile Leu Asp Asp Glu Leu Ile Gln Trp Lys 
                245                 250                 255     
Arg Arg Gln Gln Leu Ala Gly Asn Gly Gly Pro Pro Glu Gly Ser Leu 
            260                 265                 270         
Asp Val Leu Gln Ser Trp Cys Glu Lys Leu Ala Glu Ile Ile Trp Gln 
        275                 280                 285             
Asn Arg Gln Gln Ile Arg Arg Ala Glu His Leu Cys Gln Gln Leu Pro 
    290                 295                 300                 
Ile Pro Gly Pro Val Glu Glu Met Leu Ala Glu Val Asn Ala Thr Ile 
305                 310                 315                 320 
Thr Asp Ile Ile Ser Ala Leu Val Thr Ser Thr Phe Ile Ile Glu Lys 
                325                 330                 335     
Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys Phe Ala Ala Thr Val 
            340                 345                 350         
Arg Leu Leu Val Gly Gly Lys Leu Asn Val His Met Asn Pro Pro Gln 
        355                 360                 365             
Val Lys Ala Thr Ile Ile Ser Glu Gln Gln Ala Lys Ser Leu Leu Lys 
    370                 375                 380                 
Asn Glu Asn Thr Arg Asn Asp Tyr Ser Gly Glu Ile Leu Asn Asn Cys 
385                 390                 395                 400 
Cys Val Met Glu Tyr His Gln Ala Thr Gly Thr Leu Ser Ala His Phe 
                405                 410                 415     
Arg Asn Met Ser Leu Lys Arg Ile Lys Arg Ser Asp Arg Arg Gly Ala 
            420                 425                 430         
Glu Ser Val Thr Glu Glu Lys Phe Thr Ile Leu Phe Glu Ser Gln Phe 
        435                 440                 445             
Ser Val Gly Gly Asn Glu Leu Val Phe Gln Val Lys Thr Leu Ser Leu 
    450                 455                 460                 
Pro Val Val Val Ile Val His Gly Ser Gln Asp Asn Asn Ala Thr Ala 
465                 470                 475                 480 
Thr Val Leu Trp Asp Asn Ala Phe Ala Glu Pro Gly Arg Val Pro Phe 
                485                 490                 495     
Ala Val Pro Asp Lys Val Leu Trp Pro Gln Leu Cys Glu Ala Leu Asn 
            500                 505                 510         
Met Lys Phe Lys Ala Glu Val Gln Ser Asn Arg Gly Leu Thr Lys Glu 
        515                 520                 525             
Asn Leu Val Phe Leu Ala Gln Lys Leu Phe Asn Asn Ser Ser Ser His 
    530                 535                 540                 
Leu Glu Asp Tyr Ser Gly Leu Ser Val Ser Trp Ser Gln Phe Asn Arg 
545                 550                 555                 560 
Glu Asn Leu Pro Gly Arg Asn Tyr Thr Phe Trp Gln Trp Phe Asp Gly 
                565                 570                 575     
Val Met Glu Val Leu Lys Lys His Leu Lys Pro His Trp Asn Asp Gly 
            580                 585                 590         
Ala Ile Leu Gly Phe Val Asn Lys Gln Gln Ala His Asp Leu Leu Ile 
        595                 600                 605             
Asn Lys Pro Asp Gly Thr Phe Leu Leu Arg Phe Ser Asp Ser Glu Ile 
    610                 615                 620                 
Gly Gly Ile Thr Ile Ala Trp Lys Phe Asp Ser Gln Glu Arg Met Phe 
625                 630                 635                 640 
Trp Asn Leu Met Pro Phe Thr Thr Arg Asp Phe Ser Ile Arg Ser Leu 
                645                 650                 655     
Ala Asp Arg Leu Gly Asp Leu Asn Tyr Leu Ile Tyr Val Phe Pro Asp 
            660                 665                 670         
Arg Pro Lys Asp Glu Val Tyr Ser Lys Tyr Tyr Thr Pro Val Pro Cys 
        675                 680                 685             
Glu Ser Ala Thr Ala Lys Ala Val Asp Gly Tyr Val Lys Pro Gln Ile 
    690                 695                 700                 
Lys Gln Val Val Pro Glu Phe Val Asn Ala Ser Ala Asp Ala Gly Gly 
705                 710                 715                 720 
Gly Ser Ala Thr Tyr Met Asp Gln Ala Pro Ser Pro Ala Val Cys Pro 
                725                 730                 735     
Gln Ala His Tyr Asn Met Tyr Pro Gln Asn Pro Asp Ser Val Leu Asp 
            740                 745                 750         
Thr Asp Gly Asp Phe Asp Leu Glu Asp Thr Met Asp Val Ala Arg Arg 
        755                 760                 765             
Val Glu Glu Leu Leu Gly Arg Pro Met Asp Ser Gln Trp Ile Pro His 
    770                 775                 780                 
Ala Gln Ser 
785         

<210> 7
<211> 793
<212> PRT
<213> Mus musculus

<220> 
<223> STAT5A

<400> 7
Met Ala Gly Trp Ile Gln Ala Gln Gln Leu Gln Gly Asp Ala Leu Arg 
1               5                   10                  15      
Gln Met Gln Val Leu Tyr Gly Gln His Phe Pro Ile Glu Val Arg His 
            20                  25                  30          
Tyr Leu Ala Gln Trp Ile Glu Ser Gln Pro Trp Asp Ala Ile Asp Leu 
        35                  40                  45              
Asp Asn Pro Gln Asp Arg Gly Gln Ala Thr Gln Leu Leu Glu Gly Leu 
    50                  55                  60                  
Val Gln Glu Leu Gln Lys Lys Ala Glu His Gln Val Gly Glu Asp Gly 
65                  70                  75                  80  
Phe Leu Leu Lys Ile Lys Leu Gly His Tyr Ala Thr Gln Leu Gln Asn 
                85                  90                  95      
Thr Tyr Asp Arg Cys Pro Met Glu Leu Val Arg Cys Ile Arg His Ile 
            100                 105                 110         
Leu Tyr Asn Glu Gln Arg Leu Val Arg Glu Ala Asn Asn Cys Ser Ser 
        115                 120                 125             
Pro Ala Gly Val Leu Val Asp Ala Met Ser Gln Lys His Leu Gln Ile 
    130                 135                 140                 
Asn Gln Arg Phe Glu Glu Leu Arg Leu Ile Thr Gln Asp Thr Glu Asn 
145                 150                 155                 160 
Glu Leu Lys Lys Leu Gln Gln Thr Gln Glu Tyr Phe Ile Ile Gln Tyr 
                165                 170                 175     
Gln Glu Ser Leu Arg Ile Gln Ala Gln Phe Ala Gln Leu Gly Gln Leu 
            180                 185                 190         
Asn Pro Gln Glu Arg Met Ser Arg Glu Thr Ala Leu Gln Gln Lys Gln 
        195                 200                 205             
Val Ser Leu Glu Thr Trp Leu Gln Arg Glu Ala Gln Thr Leu Gln Gln 
    210                 215                 220                 
Tyr Arg Val Glu Leu Ala Glu Lys His Gln Lys Thr Leu Gln Leu Leu 
225                 230                 235                 240 
Arg Lys Gln Gln Thr Ile Ile Leu Asp Asp Glu Leu Ile Gln Trp Lys 
                245                 250                 255     
Arg Arg Gln Gln Leu Ala Gly Asn Gly Gly Pro Pro Glu Gly Ser Leu 
            260                 265                 270         
Asp Val Leu Gln Ser Trp Cys Glu Lys Leu Ala Glu Ile Ile Trp Gln 
        275                 280                 285             
Asn Arg Gln Gln Ile Arg Arg Ala Glu His Leu Cys Gln Gln Leu Pro 
    290                 295                 300                 
Ile Pro Gly Pro Val Glu Glu Met Leu Ala Glu Val Asn Ala Thr Ile 
305                 310                 315                 320 
Thr Asp Ile Ile Ser Ala Leu Val Thr Ser Thr Phe Ile Ile Glu Lys 
                325                 330                 335     
Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys Phe Ala Ala Thr Val 
            340                 345                 350         
Arg Leu Leu Val Gly Gly Lys Leu Asn Val His Met Asn Pro Pro Gln 
        355                 360                 365             
Val Lys Ala Thr Ile Ile Ser Glu Gln Gln Ala Lys Ser Leu Leu Lys 
    370                 375                 380                 
Asn Glu Asn Thr Arg Asn Glu Cys Ser Gly Glu Ile Leu Asn Asn Cys 
385                 390                 395                 400 
Cys Val Met Glu Tyr His Gln Ala Thr Gly Thr Leu Ser Ala His Phe 
                405                 410                 415     
Arg Asn Met Ser Leu Lys Arg Ile Lys Arg Ala Asp Arg Arg Gly Ala 
            420                 425                 430         
Glu Ser Val Thr Glu Glu Lys Phe Thr Val Leu Phe Glu Ser Gln Phe 
        435                 440                 445             
Ser Val Gly Ser Asn Glu Leu Val Phe Gln Val Lys Thr Leu Ser Leu 
    450                 455                 460                 
Pro Val Val Val Ile Val His Gly Ser Gln Asp His Asn Ala Thr Ala 
465                 470                 475                 480 
Thr Val Leu Trp Asp Asn Ala Phe Ala Glu Pro Gly Arg Val Pro Phe 
                485                 490                 495     
Ala Val Pro Asp Lys Val Leu Trp Pro Gln Leu Cys Glu Ala Leu Asn 
            500                 505                 510         
Met Lys Phe Lys Ala Glu Val Gln Ser Asn Arg Gly Leu Thr Lys Glu 
        515                 520                 525             
Asn Leu Val Phe Leu Ala Gln Lys Leu Phe Asn Ile Ser Ser Asn His 
    530                 535                 540                 
Leu Glu Asp Tyr Asn Ser Met Ser Val Ser Trp Ser Gln Phe Asn Arg 
545                 550                 555                 560 
Glu Asn Leu Pro Gly Trp Asn Tyr Thr Phe Trp Gln Trp Phe Asp Gly 
                565                 570                 575     
Val Met Glu Val Leu Lys Lys His His Lys Pro His Trp Asn Asp Gly 
            580                 585                 590         
Ala Ile Leu Gly Phe Val Asn Lys Gln Gln Ala His Asp Leu Leu Ile 
        595                 600                 605             
Asn Lys Pro Asp Gly Thr Phe Leu Leu Arg Phe Ser Asp Ser Glu Ile 
    610                 615                 620                 
Gly Gly Ile Thr Ile Ala Trp Lys Phe Asp Ser Pro Asp Arg Asn Leu 
625                 630                 635                 640 
Trp Asn Leu Lys Pro Phe Thr Thr Arg Asp Phe Ser Ile Arg Ser Leu 
                645                 650                 655     
Ala Asp Arg Leu Gly Asp Leu Asn Tyr Leu Ile Tyr Val Phe Pro Asp 
            660                 665                 670         
Arg Pro Lys Asp Glu Val Phe Ala Lys Tyr Tyr Thr Pro Val Leu Ala 
        675                 680                 685             
Lys Ala Val Asp Gly Tyr Val Lys Pro Gln Ile Lys Gln Val Val Pro 
    690                 695                 700                 
Glu Phe Val Asn Ala Ser Thr Asp Ala Gly Ala Ser Ala Thr Tyr Met 
705                 710                 715                 720 
Asp Gln Ala Pro Ser Pro Val Val Cys Pro Gln Pro His Tyr Asn Met 
                725                 730                 735     
Tyr Pro Pro Asn Pro Asp Pro Val Leu Asp Gln Asp Gly Glu Phe Asp 
            740                 745                 750         
Leu Asp Glu Ser Met Asp Val Ala Arg His Val Glu Glu Leu Leu Arg 
        755                 760                 765             
Arg Pro Met Asp Ser Leu Asp Ala Arg Leu Ser Pro Pro Ala Gly Leu 
    770                 775                 780                 
Phe Thr Ser Ala Arg Ser Ser Leu Ser 
785                 790             

<210> 8
<211> 786
<212> PRT
<213> Mus musculus

<220> 
<223> STAT5B

<400> 8
Met Ala Met Trp Ile Gln Ala Gln Gln Leu Gln Gly Asp Ala Leu His 
1               5                   10                  15      
Gln Met Gln Ala Leu Tyr Gly Gln His Phe Pro Ile Glu Val Arg His 
            20                  25                  30          
Tyr Leu Ser Gln Trp Ile Glu Ser Gln Ala Trp Asp Ser Ile Asp Leu 
        35                  40                  45              
Asp Asn Pro Gln Glu Asn Ile Lys Ala Thr Gln Leu Leu Glu Gly Leu 
    50                  55                  60                  
Val Gln Glu Leu Gln Lys Lys Ala Glu His Gln Val Gly Glu Asp Gly 
65                  70                  75                  80  
Phe Leu Leu Lys Ile Lys Leu Gly His Tyr Ala Thr Gln Leu Gln Ser 
                85                  90                  95      
Thr Tyr Asp Arg Cys Pro Met Glu Leu Val Arg Cys Ile Arg His Ile 
            100                 105                 110         
Leu Tyr Asn Glu Gln Arg Leu Val Arg Glu Ala Asn Asn Gly Ser Ser 
        115                 120                 125             
Pro Ala Gly Ser Leu Ala Asp Ala Met Ser Gln Lys His Leu Gln Ile 
    130                 135                 140                 
Asn Gln Thr Phe Glu Glu Leu Arg Leu Ile Thr Gln Asp Thr Glu Asn 
145                 150                 155                 160 
Glu Leu Lys Lys Leu Gln Gln Thr Gln Glu Tyr Phe Ile Ile Gln Tyr 
                165                 170                 175     
Gln Glu Ser Leu Arg Ile Gln Ala Gln Phe Ala Gln Leu Gly Gln Leu 
            180                 185                 190         
Asn Pro Gln Glu Arg Met Ser Arg Glu Thr Ala Leu Gln Gln Lys Gln 
        195                 200                 205             
Val Ser Leu Glu Thr Trp Leu Gln Arg Glu Ala Gln Thr Leu Gln Gln 
    210                 215                 220                 
Tyr Arg Val Glu Leu Ala Glu Lys His Gln Lys Thr Leu Gln Leu Leu 
225                 230                 235                 240 
Arg Lys Gln Gln Thr Ile Ile Leu Asp Asp Glu Leu Ile Gln Trp Lys 
                245                 250                 255     
Arg Arg Gln Gln Leu Ala Gly Asn Gly Gly Pro Pro Glu Gly Ser Leu 
            260                 265                 270         
Asp Val Leu Gln Ser Trp Cys Glu Lys Leu Ala Glu Ile Ile Trp Gln 
        275                 280                 285             
Asn Arg Gln Gln Ile Arg Arg Ala Glu His Leu Cys Gln Gln Leu Pro 
    290                 295                 300                 
Ile Pro Gly Pro Val Glu Glu Met Leu Ala Glu Val Asn Ala Thr Ile 
305                 310                 315                 320 
Thr Asp Ile Ile Ser Ala Leu Val Thr Ser Thr Phe Ile Ile Glu Lys 
                325                 330                 335     
Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys Phe Ala Ala Thr Val 
            340                 345                 350         
Arg Leu Leu Val Gly Gly Lys Leu Asn Val His Met Asn Pro Pro Gln 
        355                 360                 365             
Val Lys Ala Thr Ile Ile Ser Glu Gln Gln Ala Lys Ser Leu Leu Lys 
    370                 375                 380                 
Asn Glu Asn Thr Arg Asn Asp Tyr Ser Gly Glu Ile Leu Asn Asn Cys 
385                 390                 395                 400 
Cys Val Met Glu Tyr His Gln Ala Thr Gly Thr Leu Ser Ala His Phe 
                405                 410                 415     
Arg Asn Met Ser Leu Lys Arg Ile Lys Arg Ser Asp Arg Arg Gly Ala 
            420                 425                 430         
Glu Ser Val Thr Glu Glu Lys Phe Thr Ile Leu Phe Asp Ser Gln Phe 
        435                 440                 445             
Ser Val Gly Gly Asn Glu Leu Val Phe Gln Val Lys Thr Leu Ser Leu 
    450                 455                 460                 
Pro Val Val Val Ile Val His Gly Ser Gln Asp Asn Asn Ala Thr Ala 
465                 470                 475                 480 
Thr Val Leu Trp Asp Asn Ala Phe Ala Glu Pro Gly Arg Val Pro Phe 
                485                 490                 495     
Ala Val Pro Asp Lys Val Leu Trp Pro Gln Leu Cys Glu Ala Leu Asn 
            500                 505                 510         
Met Lys Phe Lys Ala Glu Val Gln Ser Asn Arg Gly Leu Thr Lys Glu 
        515                 520                 525             
Asn Leu Val Phe Leu Ala Gln Lys Leu Phe Asn Ile Ser Ser Asn His 
    530                 535                 540                 
Leu Glu Asp Tyr Asn Ser Met Ser Val Ser Trp Ser Gln Phe Asn Arg 
545                 550                 555                 560 
Glu Asn Leu Pro Gly Arg Asn Tyr Thr Phe Trp Gln Trp Phe Asp Gly 
                565                 570                 575     
Val Met Glu Val Leu Lys Lys His Leu Lys Pro His Trp Asn Asp Gly 
            580                 585                 590         
Ala Ile Leu Gly Phe Val Asn Lys Gln Gln Ala His Asp Leu Leu Ile 
        595                 600                 605             
Asn Lys Pro Asp Gly Thr Phe Leu Leu Arg Phe Ser Asp Ser Glu Ile 
    610                 615                 620                 
Gly Gly Ile Thr Ile Ala Trp Lys Phe Asp Ser Gln Glu Arg Met Phe 
625                 630                 635                 640 
Trp Asn Leu Met Pro Phe Thr Thr Arg Asp Phe Ser Ile Arg Ser Leu 
                645                 650                 655     
Ala Asp Arg Leu Gly Asp Leu Asn Tyr Leu Ile Tyr Val Phe Pro Asp 
            660                 665                 670         
Arg Pro Lys Asp Glu Val Tyr Ser Lys Tyr Tyr Thr Pro Val Pro Cys 
        675                 680                 685             
Glu Pro Ala Thr Ala Lys Ala Ala Asp Gly Tyr Val Lys Pro Gln Ile 
    690                 695                 700                 
Lys Gln Val Val Pro Glu Phe Ala Asn Ala Ser Thr Asp Ala Gly Ser 
705                 710                 715                 720 
Gly Ala Thr Tyr Met Asp Gln Ala Pro Ser Pro Val Val Cys Pro Gln 
                725                 730                 735     
Ala His Tyr Asn Met Tyr Pro Pro Asn Pro Asp Ser Val Leu Asp Thr 
            740                 745                 750         
Asp Gly Asp Phe Asp Leu Glu Asp Thr Met Asp Val Ala Arg Arg Val 
        755                 760                 765             
Glu Glu Leu Leu Gly Arg Pro Met Asp Ser Gln Trp Ile Pro His Ala 
    770                 775                 780                 
Gln Ser 
785     

<210> 9
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..18
<223> /mol_type="unassigned DNA"
      /note="amorce STAT5 sens"
      /organism="Artificial Sequence"

<400> 9
ataccagctt attcaatt                                                  18


<210> 10
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..18
<223> /mol_type="unassigned DNA"
      /note="amorce STAT5 antisens"
      /organism="Artificial Sequence"

<400> 10
agattgcact tactatct                                                  18


<210> 11
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..31
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 11
gtgggaatcc aaacccaacc agtccaccca c                                   31


<210> 12
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..32
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 12
gtgggaatcc aaacccaacc agtccaccca ca                                   32


<210> 13
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..32
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 13
gtgggaatcc aaacccaacc agtccaccca ct                                   32


<210> 14
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..32
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 14
gtgggaatcc aaacccaacc agtccaccca cc                                   32


<210> 15
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..32
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 15
gtgggaatcc aaacccaacc agtccaccca cg                                   32


<210> 16
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..32
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 16
agtgggaatc caaacccaac cagtccaccc ac                                   32


<210> 17
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..32
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 17
tgtgggaatc caaacccaac cagtccaccc ac                                   32


<210> 18
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..32
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 18
cgtgggaatc caaacccaac cagtccaccc ac                                   32


<210> 19
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..32
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 19
ggtgggaatc caaacccaac cagtccaccc ac                                   32


<210> 20
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..33
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 20
gtgggaatcc aaacccaacc agtccaccca cat                                  33


<210> 21
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..33
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 21
gtgggaatcc aaacccaacc agtccaccca cac                                  33


<210> 22
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..33
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 22
gtgggaatcc aaacccaacc agtccaccca cag                                  33


<210> 23
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..33
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 23
gtgggaatcc aaacccaacc agtccaccca caa                                  33


<210> 24
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..34
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 24
gtgggaatcc aaacccaacc agtccaccca caca                                 34


<210> 25
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..34
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 25
gtgggaatcc aaacccaacc agtccaccca cact                                 34


<210> 26
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..34
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 26
gtgggaatcc aaacccaacc agtccaccca cacg                                 34


<210> 27
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..34
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 27
gtgggaatcc aaacccaacc agtccaccca cacc                                 34


<210> 28
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..31
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 28
gtgggaatcc taacccaacc agtccaccca c                                   31


<210> 29
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..31
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 29
gtgggaatcc aaacccaacc agtccagcca c                                   31


<210> 30
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..32
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 30
gtgggaatcc aaatcccaac cagtccaccc ac                                   32


<210> 31
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..32
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 31
gtgggaatcc aaacccaacc gagtccaccc ac                                   32


<210> 32
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..28
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 32
ttgtgtctgt tcactcgtcg atacacag                                       28


<210> 33
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 33
ttgtgtctgt tcactcgtcg atacacaga                                      29


<210> 34
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 34
ttgtgtctgt tcactcgtcg atacacagt                                      29


<210> 35
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 35
ttgtgtctgt tcactcgtcg atacacagc                                      29


<210> 36
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 36
ttgtgtctgt tcactcgtcg atacacagg                                      29


<210> 37
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 37
attgtgtctg ttcactcgtc gatacacag                                      29


<210> 38
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 38
cttgtgtctg ttcactcgtc gatacacag                                      29


<210> 39
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 39
gttgtgtctg ttcactcgtc gatacacag                                      29


<210> 40
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 40
tttgtgtctg ttcactcgtc gatacacag                                      29


<210> 41
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 41
aattgtgtct gttcactcgt cgatacacag                                     30


<210> 42
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 42
tattgtgtct gttcactcgt cgatacacag                                     30


<210> 43
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 43
cattgtgtct gttcactcgt cgatacacag                                     30


<210> 44
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment Apta 2"
      /organism="Artificial Sequence"

<400> 44
gattgtgtct gttcactcgt cgatacacag                                     30


<210> 45
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 45
ttgtgtctgt tcactcgtcg atacacagaa                                     30


<210> 46
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 46
ttgtgtctgt tcactcgtcg atacacagat                                     30


<210> 47
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 47
ttgtgtctgt tcactcgtcg atacacagac                                     30


<210> 48
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 48
ttgtgtctgt tcactcgtcg atacacagag                                     30


<210> 49
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 49
ttgtgtctgt tcactcgtcg atacacagta                                     30


<210> 50
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 50
ttgtgtctgt tcactcgtcg atacacagtt                                     30


<210> 51
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 1"
      /organism="Artificial Sequence"

<400> 51
ttgtgtctgt tcactcgtcg atacacagtc                                     30


<210> 52
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 52
ttgtgtctgt tcactcgtcg atacacagtg                                     30


<210> 53
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..28
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 53
ttgtgtctgt acactcgtcg atacacag                                       28


<210> 54
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..28
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 54
ttgtgtctgt tcactcctcg atacacag                                       28


<210> 55
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 55
ttgtgtctgt tcaactcgtc gatacacag                                      29


<210> 56
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 2"
      /organism="Artificial Sequence"

<400> 56
ttgtgtctgt tcactcgtcg gatacacag                                      29


<210> 57
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..60
<223> /mol_type="unassigned DNA"
      /note="Aptamère Apta 3"
      /organism="Artificial Sequence"

<400> 57
gtgtctgttc actcgtcgat acacaacata ctcaacccag gcccctgact gctaatcccc     60


<210> 58
<211> 96
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..96
<223> /mol_type="unassigned DNA"
      /note="Aptamère Apta 3 et séquences flanquantes"
      /organism="Artificial Sequence"

<400> 58
ataccagctt attcaattgt gtctgttcac tcgtcgatac acaacatact caacccaggc     60

ccctgactgc taatccccag atagtaagtg caatct                               96


<210> 59
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..28
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 59
ttgtgtctgt tcactcgtcg atacacaa                                       28


<210> 60
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 60
ttgtgtctgt tcactcgtcg atacacaaa                                      29


<210> 61
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 61
ttgtgtctgt tcactcgtcg atacacaat                                      29


<210> 62
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 62
ttgtgtctgt tcactcgtcg atacacaac                                      29


<210> 63
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 63
ttgtgtctgt tcactcgtcg atacacaag                                      29


<210> 64
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 64
attgtgtctg ttcactcgtc gatacacaa                                      29


<210> 65
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 65
cttgtgtctg ttcactcgtc gatacacaa                                      29


<210> 66
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 66
gttgtgtctg ttcactcgtc gatacacaa                                      29


<210> 67
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 67
tttgtgtctg ttcactcgtc gatacacaa                                      29


<210> 68
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 68
aattgtgtct gttcactcgt cgatacacaa                                     30


<210> 69
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 69
tattgtgtct gttcactcgt cgatacacaa                                     30


<210> 70
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 70
cattgtgtct gttcactcgt cgatacacaa                                     30


<210> 71
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 71
gattgtgtct gttcactcgt cgatacacaa                                     30


<210> 72
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 72
ttgtgtctgt tcactcgtcg atacacaaaa                                     30


<210> 73
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 73
ttgtgtctgt tcactcgtcg atacacaaat                                     30


<210> 74
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 74
ttgtgtctgt tcactcgtcg atacacaaac                                     30


<210> 75
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 75
ttgtgtctgt tcactcgtcg atacacaaag                                     30


<210> 76
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 76
ttgtgtctgt tcactcgtcg atacacaata                                     30


<210> 77
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 77
ttgtgtctgt tcactcgtcg atacacaatt                                     30


<210> 78
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 78
ttgtgtctgt tcactcgtcg atacacaatc                                     30


<210> 79
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 79
ttgtgtctgt tcactcgtcg atacacaatg                                     30


<210> 80
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..28
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 80
ttgtgtctgt acactcgtcg atacacaa                                       28


<210> 81
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..28
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 81
ttgtgtctgt tcactcctcg atacacaa                                       28


<210> 82
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 82
ttgtgtctgt tcaactcgtc gatacacaa                                      29


<210> 83
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="fragment de Apta 3"
      /organism="Artificial Sequence"

<400> 83
ttgtgtctgt tcactcgtcg gatacacaa                                      29


<210> 84
<211> 96
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..96
<223> /mol_type="unassigned DNA"
      /note="banque aléatoire d’oligonucléotides"
      /organism="Artificial Sequence"

<220> 
<221> misc_feature
<222> 19..78
<223> /note="n est A, T, G ou C"

<400> 84
ataccagctt attcaattnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     60

nnnnnnnnnn nnnnnnnnag atagtaagtg caatct                               96


