                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  IL-21 ANTIBODIES

<130>  X20141

<150>  61/968550
<151>  2014-03-21

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asp Thr Ser Asp Val Tyr Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Pro Leu Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  2
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe His Thr Leu Arg Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  3
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asp Thr Ser Asp Val Tyr Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Pro Leu Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440             


<210>  4
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe His Thr Leu Arg Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  5
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggcta cacattcact gactactgga tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggactg attgatactt ctgatgttta tactatctac      180

aatcaaaagt tcaagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aagatatggg      300

cccctggcta tggactactg gggccagggc accctggtca ccgtctcctc agcctccacc      360

aagggcccat cggtcttccc gctagcgccc tgctccagga gcacctccga gagcacagcc      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacgaagac ctacacctgc      600

aacgtagatc acaagcccag caacaccaag gtggacaaga gagttgagtc caaatatggt      660

cccccatgcc caccctgccc agcacctgag gccgccgggg gaccatcagt cttcctgttc      720

cccccaaaac ccaaggacac tctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg      780

gtggacgtga gccaggaaga ccccgaggtc cagttcaact ggtacgtgga tggcgtggag      840

gtgcataatg ccaagacaaa gccgcgggag gagcagttca acagcacgta ccgtgtggtc      900

agcgtcctca ccgtcctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc      960

tccaacaaag gcctcccgtc ctccatcgag aaaaccatct ccaaagccaa agggcagccc     1020

cgagagccac aggtgtacac cctgccccca tcccaggagg agatgaccaa gaaccaggtc     1080

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggaaagc     1140

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1200

ttcttcctct acagcaggct aaccgtggac aagagcaggt ggcaggaggg gaatgtcttc     1260

tcatgctccg tgatgcatga ggctctgcac aaccactaca cacagaagag cctctccctg     1320

tctctgggt                                                             1329


<210>  6
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctattac acatcaagat tacactcagg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag tttcacacgc ttcggacgtt cggcggaggg      300

accaaggtgg agatcaaaag aactgtggcg gcgccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatccgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgc                             639


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8

Tyr Tyr Thr Ser Arg Leu His Ser 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  9

Gln Gln Phe His Thr Leu Arg Thr 
1               5               


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10

Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Trp Met His 
1               5                   10              


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11

Leu Ile Asp Thr Ser Asp Val Tyr Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12

Ala Arg Tyr Gly Pro Leu Ala Met Asp Tyr 
1               5                   10  


<210>  13
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This protein was recombinantly produced and is identical to the 
       homo sapien sequence.

<400>  13

Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp 
1               5                   10                  15      


Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala 
            20                  25                  30          


Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe 
        35                  40                  45              


Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile 
    50                  55                  60                  


Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn 
65                  70                  75                  80  


Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser 
                85                  90                  95      


Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu 
            100                 105                 110         


Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser 
        115                 120                 125             


Glu Asp Ser 
    130     


<210>  14
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This protein was recombinantly produced and is identical to the 
       Cynomolgus monkey sequence.

<400>  14

Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp 
1               5                   10                  15      


Gln Leu Lys Asn Tyr Val Asn Asp Leu Asp Pro Glu Phe Leu Pro Ala 
            20                  25                  30          


Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Ile Ser Cys Phe 
        35                  40                  45              


Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile 
    50                  55                  60                  


Ile Asn Leu Ser Ile Lys Lys Leu Lys Arg Lys Ser Pro Ser Thr Gly 
65                  70                  75                  80  


Ala Glu Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser 
                85                  90                  95      


Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu 
            100                 105                 110         


Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser 
        115                 120                 125             


Glu Asp Ser 
    130     


<210>  15
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This protein was recombinantly produced and is identical to the 
       mus musculus sequence.

<400>  15

His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu Arg 
1               5                   10                  15      


His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp Leu 
            20                  25                  30          


Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys Glu 
        35                  40                  45              


His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser Asn 
    50                  55                  60                  


Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu Arg 
65                  70                  75                  80  


Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile Ala 
                85                  90                  95      


Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His Leu 
        115                 120                 125             


Ser 
    


<210>  16
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This protein was recombinantly produced and is identical to the 
       rattus norvegicus sequence.

<400>  16

His Lys Ser Ser Pro Gln Arg Pro Asp His Leu Leu Ile Arg Leu Arg 
1               5                   10                  15      


His Leu Met Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp Leu 
            20                  25                  30          


Asp Pro Glu Leu Leu Thr Ala Pro Gln Asp Val Lys Gly Gln Cys Glu 
        35                  40                  45              


His Glu Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser Asn 
    50                  55                  60                  


Thr Gly Asn Asn Lys Thr Phe Ile Asn Asp Leu Leu Ala Gln Leu Arg 
65                  70                  75                  80  


Arg Arg Leu Pro Ala Lys Arg Thr Gly Asn Lys Gln Arg His Met Ala 
                85                  90                  95      


Lys Cys Pro Ser Cys Asp Leu Tyr Glu Lys Lys Thr Pro Lys Glu Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His Leu 
        115                 120                 125             


Ser 
    


<210>  17
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This protein was recombinantly produced and is identical to the 
       oryctolagus cuniculus sequence.

<400>  17

His Lys Ser Ser Ser Lys Gly Gln Asp Arg Tyr Met Ile Arg Met His 
1               5                   10                  15      


Gln Leu Leu Asp Ile Val Asp Gln Leu Gln Ser Asp Val Asn Asp Leu 
            20                  25                  30          


Asp Pro Asp Phe Leu Pro Ala Pro Gln Asp Val Gln Lys Gly Cys Glu 
        35                  40                  45              


Gln Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Pro Ala Asn 
    50                  55                  60                  


Ala Gly Asp Asn Gly Lys Arg Ile Ser Ser Leu Ile Lys Gln Leu Lys 
65                  70                  75                  80  


Arg Lys Leu Pro Ser Thr Lys Ser Lys Lys Thr Gln Lys His Arg Pro 
                85                  90                  95      


Thr Cys Pro Ser Cys Tyr Ser Tyr Glu Lys Lys Asn Leu Lys Glu Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Ser Leu Ile Gln Lys Met Ile His Gln His Leu 
        115                 120                 125             


Leu Glu His Leu Arg 
    130             


