                         SEQUENCE LISTING

<110>  Whitehead Institute for Biomedical Research
 
<120>  METHODS FOR INHIBITING PROLIFERATION OF CANCER CELLS AND USES 
       THEREOF

<130>  WIBR-140-WO1

<140>  PCT/US2015/021314
<141>  2015-03-18

<150>  US 61/955,007
<151>  2014-03-18

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA agents targeting PCSK9


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphorothioate linkage

<400>  1
gccuggaguu uauucggaat t                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA agents targeting PCSK9


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphorothioate linkage

<400>  2
uuccgaauaa acuccaggct t                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA agents targeting PCSK9


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-O-methylcytidine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Phosphorothioate linkage

<400>  3
gccuggaguu uauucggaat t                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA agents targeting PCSK9


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  4
uuccgaauaa acuccaggct t                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA agents targeting PCSK9


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methylcytidine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  5
uucuagaccu guuuugcuut t                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA agents targeting PCSK9


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methylcytidine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  6
aagcaaaaca ggucuagaat t                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA agents targeting PCSK9


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methylcytidine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methylcytidine

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methylcytidine

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methylcytidine

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  7
agguguaucu ccuagacact t                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA agents targeting PCSK9


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyluridine

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  8
gugucuagga gauacaccut t                                                 21


<210>  9
<211>  13
<212>  DNA
<213>  Artificial

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  locked nucleic acid (LNA)

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  locked nucleic acid (LNA)

<400>  9
gtctgtggaa gcg                                                          13


