                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF MICHIGAN
 
<120>  PHARMACEUTICAL COMPOSITIONS COMPRISING OCCLUDIN MUTANTS AND 
       METHODS OF INHIBITING ANGIOGENESIS THEREWITH

<130>  UM-33823/WO-1/ORD

<150>  US 61/968,805
<151>  2014-03-21

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ser Arg Pro Leu Glu Ser Pro Pro Pro Tyr Arg Pro Asp Glu 
1               5                   10                  15      


Phe Lys Pro Asn His Tyr Ala Pro Ser Asn Asp Ile Tyr Gly Gly Glu 
            20                  25                  30          


Met His Val Arg Pro Met Leu Ser Gln Pro Ala Tyr Ser Phe Tyr Pro 
        35                  40                  45              


Glu Asp Glu Ile Leu His Phe Tyr Lys Trp Thr Ser Pro Pro Gly Val 
    50                  55                  60                  


Ile Arg Ile Leu Ser Met Leu Ile Ile Val Met Cys Ile Ala Ile Phe 
65                  70                  75                  80  


Ala Cys Val Ala Ser Thr Leu Ala Trp Asp Arg Gly Tyr Gly Thr Ser 
                85                  90                  95      


Leu Leu Gly Gly Ser Val Gly Tyr Pro Tyr Gly Gly Ser Gly Phe Gly 
            100                 105                 110         


Ser Tyr Gly Ser Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Tyr 
        115                 120                 125             


Gly Gly Tyr Thr Asp Pro Arg Ala Ala Lys Gly Phe Met Leu Ala Met 
    130                 135                 140                 


Ala Ala Phe Cys Phe Ile Ala Ala Leu Val Ile Phe Val Thr Ser Val 
145                 150                 155                 160 


Ile Arg Ser Glu Met Ser Arg Thr Arg Arg Tyr Tyr Leu Ser Val Ile 
                165                 170                 175     


Ile Val Ser Ala Ile Leu Gly Ile Met Val Phe Ile Ala Thr Ile Val 
            180                 185                 190         


Tyr Ile Met Gly Val Asn Pro Thr Ala Gln Ser Ser Gly Ser Leu Tyr 
        195                 200                 205             


Gly Ser Gln Ile Tyr Ala Leu Cys Asn Gln Phe Tyr Thr Pro Ala Ala 
    210                 215                 220                 


Thr Gly Leu Tyr Val Asp Gln Tyr Leu Tyr His Tyr Cys Val Val Asp 
225                 230                 235                 240 


Pro Gln Glu Ala Ile Ala Ile Val Leu Gly Phe Met Ile Ile Val Ala 
                245                 250                 255     


Phe Ala Leu Ile Ile Phe Phe Ala Val Lys Thr Arg Arg Lys Met Asp 
            260                 265                 270         


Arg Tyr Asp Lys Ser Asn Ile Leu Trp Asp Lys Glu His Ile Tyr Asp 
        275                 280                 285             


Glu Gln Pro Pro Asn Val Glu Glu Trp Val Lys Asn Val Ser Ala Gly 
    290                 295                 300                 


Thr Gln Asp Val Pro Ser Pro Pro Ser Asp Tyr Val Glu Arg Val Asp 
305                 310                 315                 320 


Ser Pro Met Ala Tyr Ser Ser Asn Gly Lys Val Asn Asp Lys Arg Phe 
                325                 330                 335     


Tyr Pro Glu Ser Ser Tyr Lys Ser Thr Pro Val Pro Glu Val Val Gln 
            340                 345                 350         


Glu Leu Pro Leu Thr Ser Pro Val Asp Asp Phe Arg Gln Pro Arg Tyr 
        355                 360                 365             


Ser Ser Gly Gly Asn Phe Glu Thr Pro Ser Lys Arg Ala Pro Ala Lys 
    370                 375                 380                 


Gly Arg Ala Gly Arg Ser Lys Arg Thr Glu Gln Asp His Tyr Glu Thr 
385                 390                 395                 400 


Asp Tyr Thr Thr Gly Gly Glu Ser Cys Asp Glu Leu Glu Glu Asp Trp 
                405                 410                 415     


Ile Arg Glu Tyr Pro Pro Ile Thr Ser Asp Gln Gln Arg Gln Leu Tyr 
            420                 425                 430         


Lys Arg Asn Phe Asp Thr Gly Leu Gln Glu Tyr Lys Ser Leu Gln Ser 
        435                 440                 445             


Glu Leu Asp Glu Ile Asn Lys Glu Leu Ser Arg Leu Asp Lys Glu Leu 
    450                 455                 460                 


Asp Asp Tyr Arg Glu Glu Ser Glu Glu Tyr Met Ala Ala Ala Asp Glu 
465                 470                 475                 480 


Tyr Asn Arg Leu Lys Gln Val Lys Gly Ser Ala Asp Tyr Lys Ser Lys 
                485                 490                 495     


Lys Asn His Cys Lys Gln Leu Lys Ser Lys Leu Ser His Ile Lys Lys 
            500                 505                 510         


Met Val Gly Asp Tyr Asp Arg Gln Lys Thr 
        515                 520         


<210>  2
<211>  522
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  2

Met Ser Ser Arg Pro Leu Glu Ser Pro Pro Pro Tyr Arg Pro Asp Glu 
1               5                   10                  15      


Phe Lys Pro Asn His Tyr Ala Pro Ser Asn Asp Ile Tyr Gly Gly Glu 
            20                  25                  30          


Met His Val Arg Pro Met Leu Ser Gln Pro Ala Tyr Ser Phe Tyr Pro 
        35                  40                  45              


Glu Asp Glu Ile Leu His Phe Tyr Lys Trp Thr Ser Pro Pro Gly Val 
    50                  55                  60                  


Ile Arg Ile Leu Ser Met Leu Ile Ile Val Met Cys Ile Ala Ile Phe 
65                  70                  75                  80  


Ala Cys Val Ala Ser Thr Leu Ala Trp Asp Arg Gly Tyr Gly Thr Ser 
                85                  90                  95      


Leu Leu Gly Gly Ser Val Gly Tyr Pro Tyr Gly Gly Ser Gly Phe Gly 
            100                 105                 110         


Ser Tyr Gly Ser Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Tyr 
        115                 120                 125             


Gly Gly Tyr Thr Asp Pro Arg Ala Ala Lys Gly Phe Met Leu Ala Met 
    130                 135                 140                 


Ala Ala Phe Cys Phe Ile Ala Ala Leu Val Ile Phe Val Thr Ser Val 
145                 150                 155                 160 


Ile Arg Ser Glu Met Ser Arg Thr Arg Arg Tyr Tyr Leu Ser Val Ile 
                165                 170                 175     


Ile Val Ser Ala Ile Leu Gly Ile Met Val Phe Ile Ala Thr Ile Val 
            180                 185                 190         


Tyr Ile Met Gly Val Asn Pro Thr Ala Gln Ser Ser Gly Ser Leu Tyr 
        195                 200                 205             


Gly Ser Gln Ile Tyr Ala Leu Cys Asn Gln Phe Tyr Thr Pro Ala Ala 
    210                 215                 220                 


Thr Gly Leu Tyr Val Asp Gln Tyr Leu Tyr His Tyr Cys Val Val Asp 
225                 230                 235                 240 


Pro Gln Glu Ala Ile Ala Ile Val Leu Gly Phe Met Ile Ile Val Ala 
                245                 250                 255     


Phe Ala Leu Ile Ile Phe Phe Ala Val Lys Thr Arg Arg Lys Met Asp 
            260                 265                 270         


Arg Tyr Asp Lys Ser Asn Ile Leu Trp Asp Lys Glu His Ile Tyr Asp 
        275                 280                 285             


Glu Gln Pro Pro Asn Val Glu Glu Trp Val Lys Asn Val Ser Ala Gly 
    290                 295                 300                 


Thr Gln Asp Val Pro Ser Pro Pro Ser Asp Tyr Val Glu Arg Val Asp 
305                 310                 315                 320 


Ser Pro Met Ala Tyr Ser Ser Asn Gly Lys Val Asn Asp Lys Arg Phe 
                325                 330                 335     


Tyr Pro Glu Ser Ser Tyr Lys Ser Thr Pro Val Pro Glu Val Val Gln 
            340                 345                 350         


Glu Leu Pro Leu Thr Ser Pro Val Asp Asp Phe Arg Gln Pro Arg Tyr 
        355                 360                 365             


Ser Ser Gly Gly Asn Phe Glu Thr Pro Ser Lys Arg Ala Pro Ala Lys 
    370                 375                 380                 


Gly Arg Ala Gly Arg Ser Lys Arg Thr Glu Gln Asp His Tyr Glu Thr 
385                 390                 395                 400 


Asp Tyr Thr Thr Gly Gly Glu Ser Cys Asp Glu Leu Glu Glu Asp Trp 
                405                 410                 415     


Ile Arg Glu Tyr Pro Pro Ile Thr Ser Asp Gln Gln Arg Gln Leu Tyr 
            420                 425                 430         


Lys Arg Asn Phe Asp Thr Gly Leu Gln Glu Tyr Lys Ser Leu Gln Ser 
        435                 440                 445             


Glu Leu Asp Glu Ile Asn Lys Glu Leu Ser Arg Leu Asp Lys Glu Leu 
    450                 455                 460                 


Asp Asp Tyr Arg Glu Glu Ser Glu Glu Tyr Met Ala Ala Ala Asp Glu 
465                 470                 475                 480 


Tyr Asn Arg Leu Lys Gln Val Lys Gly Ala Ala Asp Tyr Lys Ser Lys 
                485                 490                 495     


Lys Asn His Cys Lys Gln Leu Lys Ser Lys Leu Ser His Ile Lys Lys 
            500                 505                 510         


Met Val Gly Asp Tyr Asp Arg Gln Lys Thr 
        515                 520         


<210>  3
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  3
auaaagaacu ggaugacuau u                                                 21


