                         SEQUENCE LISTING

<110>  Swedish Orphan Biovitrum AB
 
<120>  METHOD OF TREATMENT

<130>  21066708

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  722
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Lys Leu Gly Ala Val Tyr Thr Glu Gly Gly Phe Val Glu Gly Val 
1               5                   10                  15      


Asn Lys Lys Leu Gly Leu Leu Gly Asp Ser Val Asp Ile Phe Lys Gly 
            20                  25                  30          


Ile Pro Phe Ala Ala Pro Thr Lys Ala Leu Glu Asn Pro Gln Pro His 
        35                  40                  45              


Pro Gly Trp Gln Gly Thr Leu Lys Ala Lys Asn Phe Lys Lys Arg Cys 
    50                  55                  60                  


Leu Gln Ala Thr Ile Thr Gln Asp Ser Thr Tyr Gly Asp Glu Asp Cys 
65                  70                  75                  80  


Leu Tyr Leu Asn Ile Trp Val Pro Gln Gly Arg Lys Gln Val Ser Arg 
                85                  90                  95      


Asp Leu Pro Val Met Ile Trp Ile Tyr Gly Gly Ala Phe Leu Met Gly 
            100                 105                 110         


Ser Gly His Gly Ala Asn Phe Leu Asn Asn Tyr Leu Tyr Asp Gly Glu 
        115                 120                 125             


Glu Ile Ala Thr Arg Gly Asn Val Ile Val Val Thr Phe Asn Tyr Arg 
    130                 135                 140                 


Val Gly Pro Leu Gly Phe Leu Ser Thr Gly Asp Ala Asn Leu Pro Gly 
145                 150                 155                 160 


Asn Tyr Gly Leu Arg Asp Gln His Met Ala Ile Ala Trp Val Lys Arg 
                165                 170                 175     


Asn Ile Ala Ala Phe Gly Gly Asp Pro Asn Asn Ile Thr Leu Phe Gly 
            180                 185                 190         


Glu Ser Ala Gly Gly Ala Ser Val Ser Leu Gln Thr Leu Ser Pro Tyr 
        195                 200                 205             


Asn Lys Gly Leu Ile Arg Arg Ala Ile Ser Gln Ser Gly Val Ala Leu 
    210                 215                 220                 


Ser Pro Trp Val Ile Gln Lys Asn Pro Leu Phe Trp Ala Lys Lys Val 
225                 230                 235                 240 


Ala Glu Lys Val Gly Cys Pro Val Gly Asp Ala Ala Arg Met Ala Gln 
                245                 250                 255     


Cys Leu Lys Val Thr Asp Pro Arg Ala Leu Thr Leu Ala Tyr Lys Val 
            260                 265                 270         


Pro Leu Ala Gly Leu Glu Tyr Pro Met Leu His Tyr Val Gly Phe Val 
        275                 280                 285             


Pro Val Ile Asp Gly Asp Phe Ile Pro Ala Asp Pro Ile Asn Leu Tyr 
    290                 295                 300                 


Ala Asn Ala Ala Asp Ile Asp Tyr Ile Ala Gly Thr Asn Asn Met Asp 
305                 310                 315                 320 


Gly His Ile Phe Ala Ser Ile Asp Met Pro Ala Ile Asn Lys Gly Asn 
                325                 330                 335     


Lys Lys Val Thr Glu Glu Asp Phe Tyr Lys Leu Val Ser Glu Phe Thr 
            340                 345                 350         


Ile Thr Lys Gly Leu Arg Gly Ala Lys Thr Thr Phe Asp Val Tyr Thr 
        355                 360                 365             


Glu Ser Trp Ala Gln Asp Pro Ser Gln Glu Asn Lys Lys Lys Thr Val 
    370                 375                 380                 


Val Asp Phe Glu Thr Asp Val Leu Phe Leu Val Pro Thr Glu Ile Ala 
385                 390                 395                 400 


Leu Ala Gln His Arg Ala Asn Ala Lys Ser Ala Lys Thr Tyr Ala Tyr 
                405                 410                 415     


Leu Phe Ser His Pro Ser Arg Met Pro Val Tyr Pro Lys Trp Val Gly 
            420                 425                 430         


Ala Asp His Ala Asp Asp Ile Gln Tyr Val Phe Gly Lys Pro Phe Ala 
        435                 440                 445             


Thr Pro Thr Gly Tyr Arg Pro Gln Asp Arg Thr Val Ser Lys Ala Met 
    450                 455                 460                 


Ile Ala Tyr Trp Thr Asn Phe Ala Lys Thr Gly Asp Pro Asn Met Gly 
465                 470                 475                 480 


Asp Ser Ala Val Pro Thr His Trp Glu Pro Tyr Thr Thr Glu Asn Ser 
                485                 490                 495     


Gly Tyr Leu Glu Ile Thr Lys Lys Met Gly Ser Ser Ser Met Lys Arg 
            500                 505                 510         


Ser Leu Arg Thr Asn Phe Leu Arg Tyr Trp Thr Leu Thr Tyr Leu Ala 
        515                 520                 525             


Leu Pro Thr Val Thr Asp Gln Glu Ala Thr Pro Val Pro Pro Thr Gly 
    530                 535                 540                 


Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala 
545                 550                 555                 560 


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
                565                 570                 575     


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            580                 585                 590         


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        595                 600                 605             


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    610                 615                 620                 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
625                 630                 635                 640 


Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser 
                645                 650                 655     


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            660                 665                 670         


Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp 
        675                 680                 685             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro 
    690                 695                 700                 


Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Gln Met Pro Ala Val Ile 
705                 710                 715                 720 


Arg Phe 
        


<210>  2
<211>  2428
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (151)..(2316)

<400>  2
accttctgta tcagttaagt gtcaagatgg aaggaacagc agtctcaaga taatgcaaag       60

agtttattca tccagaggct gatgctcacc atggggcgcc tgcaactggt tgtgttgggc      120

ctcacctgct gctgggcagt ggcgagtgcc gcg aag ctg ggc gcc gtg tac aca       174
                                 Ala Lys Leu Gly Ala Val Tyr Thr          
                                 1               5                        

gaa ggt ggg ttc gtg gaa ggc gtc aat aag aag ctc ggc ctc ctg ggt        222
Glu Gly Gly Phe Val Glu Gly Val Asn Lys Lys Leu Gly Leu Leu Gly           
    10                  15                  20                            

gac tct gtg gac atc ttc aag ggc atc ccc ttc gca gct ccc acc aag        270
Asp Ser Val Asp Ile Phe Lys Gly Ile Pro Phe Ala Ala Pro Thr Lys           
25                  30                  35                  40            

gcc ctg gaa aat cct cag cca cat cct ggc tgg caa ggg acc ctg aag        318
Ala Leu Glu Asn Pro Gln Pro His Pro Gly Trp Gln Gly Thr Leu Lys           
                45                  50                  55                

gcc aag aac ttc aag aag aga tgc ctg cag gcc acc atc acc cag gac        366
Ala Lys Asn Phe Lys Lys Arg Cys Leu Gln Ala Thr Ile Thr Gln Asp           
            60                  65                  70                    

agc acc tac ggg gat gaa gac tgc ctg tac ctc aac att tgg gtg ccc        414
Ser Thr Tyr Gly Asp Glu Asp Cys Leu Tyr Leu Asn Ile Trp Val Pro           
        75                  80                  85                        

cag ggc agg aag caa gtc tcc cgg gac ctg ccc gtt atg atc tgg atc        462
Gln Gly Arg Lys Gln Val Ser Arg Asp Leu Pro Val Met Ile Trp Ile           
    90                  95                  100                           

tat gga ggc gcc ttc ctc atg ggg tcc ggc cat ggg gcc aac ttc ctc        510
Tyr Gly Gly Ala Phe Leu Met Gly Ser Gly His Gly Ala Asn Phe Leu           
105                 110                 115                 120           

aac aac tac ctg tat gac ggc gag gag atc gcc aca cgc gga aac gtc        558
Asn Asn Tyr Leu Tyr Asp Gly Glu Glu Ile Ala Thr Arg Gly Asn Val           
                125                 130                 135               

atc gtg gtc acc ttc aac tac cgt gtc ggc ccc ctt ggg ttc ctc agc        606
Ile Val Val Thr Phe Asn Tyr Arg Val Gly Pro Leu Gly Phe Leu Ser           
            140                 145                 150                   

act ggg gac gcc aat ctg cca ggt aac tat ggc ctt cgg gat cag cac        654
Thr Gly Asp Ala Asn Leu Pro Gly Asn Tyr Gly Leu Arg Asp Gln His           
        155                 160                 165                       

atg gcc att gct tgg gtg aag agg aat atc gcg gcc ttc ggg ggg gac        702
Met Ala Ile Ala Trp Val Lys Arg Asn Ile Ala Ala Phe Gly Gly Asp           
    170                 175                 180                           

ccc aac aac atc acg ctc ttc ggg gag tct gct gga ggt gcc agc gtc        750
Pro Asn Asn Ile Thr Leu Phe Gly Glu Ser Ala Gly Gly Ala Ser Val           
185                 190                 195                 200           

tct ctg cag acc ctc tcc ccc tac aac aag ggc ctc atc cgg cga gcc        798
Ser Leu Gln Thr Leu Ser Pro Tyr Asn Lys Gly Leu Ile Arg Arg Ala           
                205                 210                 215               

atc agc cag agc ggc gtg gcc ctg agt ccc tgg gtc atc cag aaa aac        846
Ile Ser Gln Ser Gly Val Ala Leu Ser Pro Trp Val Ile Gln Lys Asn           
            220                 225                 230                   

cca ctc ttc tgg gcc aaa aag gtg gct gag aag gtg ggt tgc cct gtg        894
Pro Leu Phe Trp Ala Lys Lys Val Ala Glu Lys Val Gly Cys Pro Val           
        235                 240                 245                       

ggt gat gcc gcc agg atg gcc cag tgt ctg aag gtt act gat ccc cga        942
Gly Asp Ala Ala Arg Met Ala Gln Cys Leu Lys Val Thr Asp Pro Arg           
    250                 255                 260                           

gcc ctg acg ctg gcc tat aag gtg ccg ctg gca ggc ctg gag tac ccc        990
Ala Leu Thr Leu Ala Tyr Lys Val Pro Leu Ala Gly Leu Glu Tyr Pro           
265                 270                 275                 280           

atg ctg cac tat gtg ggc ttc gtc cct gtc att gat gga gac ttc atc       1038
Met Leu His Tyr Val Gly Phe Val Pro Val Ile Asp Gly Asp Phe Ile           
                285                 290                 295               

ccc gct gac ccg atc aac ctg tac gcc aac gcc gcc gac atc gac tat       1086
Pro Ala Asp Pro Ile Asn Leu Tyr Ala Asn Ala Ala Asp Ile Asp Tyr           
            300                 305                 310                   

ata gca ggc acc aac aac atg gac ggc cac atc ttc gcc agc atc gac       1134
Ile Ala Gly Thr Asn Asn Met Asp Gly His Ile Phe Ala Ser Ile Asp           
        315                 320                 325                       

atg cct gcc atc aac aag ggc aac aag aaa gtc acg gag gag gac ttc       1182
Met Pro Ala Ile Asn Lys Gly Asn Lys Lys Val Thr Glu Glu Asp Phe           
    330                 335                 340                           

tac aag ctg gtc agt gag ttc aca atc acc aag ggg ctc aga ggc gcc       1230
Tyr Lys Leu Val Ser Glu Phe Thr Ile Thr Lys Gly Leu Arg Gly Ala           
345                 350                 355                 360           

aag acg acc ttt gat gtc tac acc gag tcc tgg gcc cag gac cca tcc       1278
Lys Thr Thr Phe Asp Val Tyr Thr Glu Ser Trp Ala Gln Asp Pro Ser           
                365                 370                 375               

cag gag aat aag aag aag act gtg gtg gac ttt gag acc gat gtc ctc       1326
Gln Glu Asn Lys Lys Lys Thr Val Val Asp Phe Glu Thr Asp Val Leu           
            380                 385                 390                   

ttc ctg gtg ccc acc gag att gcc cta gcc cag cac aga gcc aat gcc       1374
Phe Leu Val Pro Thr Glu Ile Ala Leu Ala Gln His Arg Ala Asn Ala           
        395                 400                 405                       

aag agt gcc aag acc tac gcc tac ctg ttt tcc cat ccc tct cgg atg       1422
Lys Ser Ala Lys Thr Tyr Ala Tyr Leu Phe Ser His Pro Ser Arg Met           
    410                 415                 420                           

ccc gtc tac ccc aaa tgg gtg ggg gcc gac cat gca gat gac att cag       1470
Pro Val Tyr Pro Lys Trp Val Gly Ala Asp His Ala Asp Asp Ile Gln           
425                 430                 435                 440           

tac gtt ttc ggg aag ccc ttc gcc acc ccc acg ggc tac cgg ccc caa       1518
Tyr Val Phe Gly Lys Pro Phe Ala Thr Pro Thr Gly Tyr Arg Pro Gln           
                445                 450                 455               

gac agg aca gtc tct aag gcc atg atc gcc tac tgg acc aac ttt gcc       1566
Asp Arg Thr Val Ser Lys Ala Met Ile Ala Tyr Trp Thr Asn Phe Ala           
            460                 465                 470                   

aaa aca ggg gac ccc aac atg ggc gac tcg gct gtg ccc aca cac tgg       1614
Lys Thr Gly Asp Pro Asn Met Gly Asp Ser Ala Val Pro Thr His Trp           
        475                 480                 485                       

gaa ccc tac act acg gaa aac agc ggc tac ctg gag atc acc aag aag       1662
Glu Pro Tyr Thr Thr Glu Asn Ser Gly Tyr Leu Glu Ile Thr Lys Lys           
    490                 495                 500                           

atg ggc agc agc tcc atg aag cgg agc ctg aga acc aac ttc ctg cgc       1710
Met Gly Ser Ser Ser Met Lys Arg Ser Leu Arg Thr Asn Phe Leu Arg           
505                 510                 515                 520           

tac tgg acc ctc acc tat ctg gcg ctg ccc aca gtg acc gac cag gag       1758
Tyr Trp Thr Leu Thr Tyr Leu Ala Leu Pro Thr Val Thr Asp Gln Glu           
                525                 530                 535               

gcc acc cct gtg ccc ccc aca ggg gac tcc gag gcc act ccc gtg ccc       1806
Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro           
            540                 545                 550                   

ccc acg ggt gac tcc gag acc gcc ccc gtg ccg ccc acg ggt gac tcc       1854
Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser           
        555                 560                 565                       

ggg gcc ccc ccc gtg ccg ccc acg ggt gac tcc ggg gcc ccc ccc gtg       1902
Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val           
    570                 575                 580                           

ccg ccc acg ggt gac tcc ggg gcc ccc ccc gtg ccg ccc acg ggt gac       1950
Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp           
585                 590                 595                 600           

tcc ggg gcc ccc ccc gtg ccg ccc acg ggt gac tcc ggg gcc ccc ccc       1998
Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro           
                605                 610                 615               

gtg ccg ccc acg ggt gac tcc ggg gcc ccc ccc gtg ccg ccc acg ggt       2046
Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly           
            620                 625                 630                   

gac tcc ggc gcc ccc ccc gtg ccg ccc acg ggt gac gcc ggg ccc ccc       2094
Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro           
        635                 640                 645                       

ccc gtg ccg ccc acg ggt gac tcc ggc gcc ccc ccc gtg ccg ccc acg       2142
Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr           
    650                 655                 660                           

ggt gac tcc ggg gcc ccc ccc gtg acc ccc acg ggt gac tcc gag acc       2190
Gly Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr           
665                 670                 675                 680           

gcc ccc gtg ccg ccc acg ggt gac tcc ggg gcc ccc cct gtg ccc ccc       2238
Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro           
                685                 690                 695               

acg ggt gac tct gag gct gcc cct gtg ccc ccc aca gat gac tcc aag       2286
Thr Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys           
            700                 705                 710                   

gaa gct cag atg cct gca gtc att agg ttt tagcgtccca tgagccttgg         2336
Glu Ala Gln Met Pro Ala Val Ile Arg Phe                                   
        715                 720                                           

tatcaagagg ccacaagagt gggaccccag gggctcccct cccatcttga gctcttcctg     2396

aataaagcct cataccccta aaaaaaaaaa aa                                   2428


