               SEQUENCE LISTING

<110> INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
      INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE
      CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

<120> Nouveaux flavonoides O-alpha-glucosyles sur le cycle B, procede d'obtention et utilisations

<130> PR71977

<150> FR1456417
<151> 2014-07-03
<150> FR1452461
<151> 2014-03-24

<160> 13

<170> BiSSAP 1.3

<210> 1
<211> 628
<212> PRT
<213> Neisseria polysaccharea

<220> 
<221> VARIANT
<222> 226
<223> Xaa est choisi parmi A, C, E, F, G, H, I, K, M, N, P, Q, S, T, V
      et Y

<400> 1
Ser Pro Asn Ser Gln Tyr Leu Lys Thr Arg Ile Leu Asp Ile Tyr Thr 
1               5                   10                  15      
Pro Glu Gln Arg Ala Gly Ile Glu Lys Ser Glu Asp Trp Arg Gln Phe 
            20                  25                  30          
Ser Arg Arg Met Asp Thr His Phe Pro Lys Leu Met Asn Glu Leu Asp 
        35                  40                  45              
Ser Val Tyr Gly Asn Asn Glu Ala Leu Leu Pro Met Leu Glu Met Leu 
    50                  55                  60                  
Leu Ala Gln Ala Trp Gln Ser Tyr Ser Gln Arg Asn Ser Ser Leu Lys 
65                  70                  75                  80  
Asp Ile Asp Ile Ala Arg Glu Asn Asn Pro Asp Trp Ile Leu Ser Asn 
                85                  90                  95      
Lys Gln Val Gly Gly Val Cys Tyr Val Asp Leu Phe Ala Gly Asp Leu 
            100                 105                 110         
Lys Gly Leu Lys Asp Lys Ile Pro Tyr Phe Gln Glu Leu Gly Leu Thr 
        115                 120                 125             
Tyr Leu His Leu Met Pro Leu Phe Lys Cys Pro Glu Gly Lys Ser Asp 
    130                 135                 140                 
Gly Gly Tyr Ala Val Ser Ser Tyr Arg Asp Val Asn Pro Ala Leu Gly 
145                 150                 155                 160 
Thr Ile Gly Asp Leu Arg Glu Val Ile Ala Ala Leu His Glu Ala Gly 
                165                 170                 175     
Ile Ser Ala Val Val Asp Phe Ile Phe Asn His Thr Ser Asn Glu His 
            180                 185                 190         
Glu Trp Ala Gln Arg Cys Ala Ala Gly Asp Pro Leu Phe Asp Asn Phe 
        195                 200                 205             
Tyr Tyr Ile Phe Pro Asp Arg Arg Met Pro Asp Gln Tyr Asp Arg Thr 
    210                 215                 220                 
Leu Xaa Glu Ile Phe Pro Asp Gln His Pro Gly Gly Phe Ser Gln Leu 
225                 230                 235                 240 
Glu Asp Gly Arg Trp Val Trp Thr Thr Phe Asn Ser Phe Gln Trp Asp 
                245                 250                 255     
Leu Asn Tyr Ser Asn Pro Trp Val Phe Arg Ala Met Ala Gly Glu Met 
            260                 265                 270         
Leu Phe Leu Ala Asn Leu Gly Val Asp Ile Leu Arg Met Asp Ala Val 
        275                 280                 285             
Ala Phe Ile Trp Lys Gln Met Gly Thr Ser Cys Glu Asn Leu Pro Gln 
    290                 295                 300                 
Ala His Ala Leu Ile Arg Ala Phe Asn Ala Val Met Arg Ile Ala Ala 
305                 310                 315                 320 
Pro Ala Val Phe Phe Lys Ser Glu Ala Ile Val His Pro Asp Gln Val 
                325                 330                 335     
Val Gln Tyr Ile Gly Gln Asp Glu Cys Gln Ile Gly Tyr Asn Pro Leu 
            340                 345                 350         
Gln Met Ala Leu Leu Trp Asn Thr Leu Ala Thr Arg Glu Val Asn Leu 
        355                 360                 365             
Leu His Gln Ala Leu Thr Tyr Arg His Asn Leu Pro Glu His Thr Ala 
    370                 375                 380                 
Trp Val Asn Tyr Val Arg Ser His Asp Asp Ile Gly Trp Thr Phe Ala 
385                 390                 395                 400 
Asp Glu Asp Ala Ala Tyr Leu Gly Ile Ser Gly Tyr Asp His Arg Gln 
                405                 410                 415     
Phe Leu Asn Arg Phe Phe Val Asn Arg Phe Asp Gly Ser Phe Ala Arg 
            420                 425                 430         
Gly Val Pro Phe Gln Tyr Asn Pro Ser Thr Gly Asp Cys Arg Val Ser 
        435                 440                 445             
Gly Thr Ala Ala Ala Leu Val Gly Leu Ala Gln Asp Asp Pro His Ala 
    450                 455                 460                 
Val Asp Arg Ile Lys Leu Leu Tyr Ser Ile Ala Leu Ser Thr Gly Gly 
465                 470                 475                 480 
Leu Pro Leu Ile Tyr Leu Gly Asp Glu Val Gly Thr Leu Asn Asp Asp 
                485                 490                 495     
Asp Trp Ser Gln Asp Ser Asn Lys Ser Asp Asp Ser Arg Trp Ala His 
            500                 505                 510         
Arg Pro Arg Tyr Asn Glu Ala Leu Tyr Ala Gln Arg Asn Asp Pro Ser 
        515                 520                 525             
Thr Ala Ala Gly Gln Ile Tyr Gln Asp Leu Arg His Met Ile Ala Val 
    530                 535                 540                 
Arg Gln Ser Asn Pro Arg Phe Asp Gly Gly Arg Leu Val Thr Phe Asn 
545                 550                 555                 560 
Thr Asn Asn Lys His Ile Ile Gly Tyr Ile Arg Asn Asn Ala Leu Leu 
                565                 570                 575     
Ala Phe Gly Asn Phe Ser Glu Tyr Pro Gln Thr Val Thr Ala His Thr 
            580                 585                 590         
Leu Gln Ala Met Pro Phe Lys Ala His Asp Leu Ile Gly Gly Lys Thr 
        595                 600                 605             
Val Ser Leu Asn Gln Asp Leu Thr Leu Gln Pro Tyr Gln Val Met Trp 
    610                 615                 620                 
Leu Glu Ile Ala 
625             

<210> 2
<211> 628
<212> PRT
<213> Neisseria polysaccharea

<220> 
<221> VARIANT
<222> 228
<223> Xaa est choisi parmi A, C, D, F, G, H, K, L, M, N, P, S, V et Y

<400> 2
Ser Pro Asn Ser Gln Tyr Leu Lys Thr Arg Ile Leu Asp Ile Tyr Thr 
1               5                   10                  15      
Pro Glu Gln Arg Ala Gly Ile Glu Lys Ser Glu Asp Trp Arg Gln Phe 
            20                  25                  30          
Ser Arg Arg Met Asp Thr His Phe Pro Lys Leu Met Asn Glu Leu Asp 
        35                  40                  45              
Ser Val Tyr Gly Asn Asn Glu Ala Leu Leu Pro Met Leu Glu Met Leu 
    50                  55                  60                  
Leu Ala Gln Ala Trp Gln Ser Tyr Ser Gln Arg Asn Ser Ser Leu Lys 
65                  70                  75                  80  
Asp Ile Asp Ile Ala Arg Glu Asn Asn Pro Asp Trp Ile Leu Ser Asn 
                85                  90                  95      
Lys Gln Val Gly Gly Val Cys Tyr Val Asp Leu Phe Ala Gly Asp Leu 
            100                 105                 110         
Lys Gly Leu Lys Asp Lys Ile Pro Tyr Phe Gln Glu Leu Gly Leu Thr 
        115                 120                 125             
Tyr Leu His Leu Met Pro Leu Phe Lys Cys Pro Glu Gly Lys Ser Asp 
    130                 135                 140                 
Gly Gly Tyr Ala Val Ser Ser Tyr Arg Asp Val Asn Pro Ala Leu Gly 
145                 150                 155                 160 
Thr Ile Gly Asp Leu Arg Glu Val Ile Ala Ala Leu His Glu Ala Gly 
                165                 170                 175     
Ile Ser Ala Val Val Asp Phe Ile Phe Asn His Thr Ser Asn Glu His 
            180                 185                 190         
Glu Trp Ala Gln Arg Cys Ala Ala Gly Asp Pro Leu Phe Asp Asn Phe 
        195                 200                 205             
Tyr Tyr Ile Phe Pro Asp Arg Arg Met Pro Asp Gln Tyr Asp Arg Thr 
    210                 215                 220                 
Leu Arg Glu Xaa Phe Pro Asp Gln His Pro Gly Gly Phe Ser Gln Leu 
225                 230                 235                 240 
Glu Asp Gly Arg Trp Val Trp Thr Thr Phe Asn Ser Phe Gln Trp Asp 
                245                 250                 255     
Leu Asn Tyr Ser Asn Pro Trp Val Phe Arg Ala Met Ala Gly Glu Met 
            260                 265                 270         
Leu Phe Leu Ala Asn Leu Gly Val Asp Ile Leu Arg Met Asp Ala Val 
        275                 280                 285             
Ala Phe Ile Trp Lys Gln Met Gly Thr Ser Cys Glu Asn Leu Pro Gln 
    290                 295                 300                 
Ala His Ala Leu Ile Arg Ala Phe Asn Ala Val Met Arg Ile Ala Ala 
305                 310                 315                 320 
Pro Ala Val Phe Phe Lys Ser Glu Ala Ile Val His Pro Asp Gln Val 
                325                 330                 335     
Val Gln Tyr Ile Gly Gln Asp Glu Cys Gln Ile Gly Tyr Asn Pro Leu 
            340                 345                 350         
Gln Met Ala Leu Leu Trp Asn Thr Leu Ala Thr Arg Glu Val Asn Leu 
        355                 360                 365             
Leu His Gln Ala Leu Thr Tyr Arg His Asn Leu Pro Glu His Thr Ala 
    370                 375                 380                 
Trp Val Asn Tyr Val Arg Ser His Asp Asp Ile Gly Trp Thr Phe Ala 
385                 390                 395                 400 
Asp Glu Asp Ala Ala Tyr Leu Gly Ile Ser Gly Tyr Asp His Arg Gln 
                405                 410                 415     
Phe Leu Asn Arg Phe Phe Val Asn Arg Phe Asp Gly Ser Phe Ala Arg 
            420                 425                 430         
Gly Val Pro Phe Gln Tyr Asn Pro Ser Thr Gly Asp Cys Arg Val Ser 
        435                 440                 445             
Gly Thr Ala Ala Ala Leu Val Gly Leu Ala Gln Asp Asp Pro His Ala 
    450                 455                 460                 
Val Asp Arg Ile Lys Leu Leu Tyr Ser Ile Ala Leu Ser Thr Gly Gly 
465                 470                 475                 480 
Leu Pro Leu Ile Tyr Leu Gly Asp Glu Val Gly Thr Leu Asn Asp Asp 
                485                 490                 495     
Asp Trp Ser Gln Asp Ser Asn Lys Ser Asp Asp Ser Arg Trp Ala His 
            500                 505                 510         
Arg Pro Arg Tyr Asn Glu Ala Leu Tyr Ala Gln Arg Asn Asp Pro Ser 
        515                 520                 525             
Thr Ala Ala Gly Gln Ile Tyr Gln Asp Leu Arg His Met Ile Ala Val 
    530                 535                 540                 
Arg Gln Ser Asn Pro Arg Phe Asp Gly Gly Arg Leu Val Thr Phe Asn 
545                 550                 555                 560 
Thr Asn Asn Lys His Ile Ile Gly Tyr Ile Arg Asn Asn Ala Leu Leu 
                565                 570                 575     
Ala Phe Gly Asn Phe Ser Glu Tyr Pro Gln Thr Val Thr Ala His Thr 
            580                 585                 590         
Leu Gln Ala Met Pro Phe Lys Ala His Asp Leu Ile Gly Gly Lys Thr 
        595                 600                 605             
Val Ser Leu Asn Gln Asp Leu Thr Leu Gln Pro Tyr Gln Val Met Trp 
    610                 615                 620                 
Leu Glu Ile Ala 
625             

<210> 3
<211> 628
<212> PRT
<213> Neisseria polysaccharea

<220> 
<221> VARIANT
<222> 229
<223> Xaa est choisi parmi A, C, G, I, K, M, N et W

<400> 3
Ser Pro Asn Ser Gln Tyr Leu Lys Thr Arg Ile Leu Asp Ile Tyr Thr 
1               5                   10                  15      
Pro Glu Gln Arg Ala Gly Ile Glu Lys Ser Glu Asp Trp Arg Gln Phe 
            20                  25                  30          
Ser Arg Arg Met Asp Thr His Phe Pro Lys Leu Met Asn Glu Leu Asp 
        35                  40                  45              
Ser Val Tyr Gly Asn Asn Glu Ala Leu Leu Pro Met Leu Glu Met Leu 
    50                  55                  60                  
Leu Ala Gln Ala Trp Gln Ser Tyr Ser Gln Arg Asn Ser Ser Leu Lys 
65                  70                  75                  80  
Asp Ile Asp Ile Ala Arg Glu Asn Asn Pro Asp Trp Ile Leu Ser Asn 
                85                  90                  95      
Lys Gln Val Gly Gly Val Cys Tyr Val Asp Leu Phe Ala Gly Asp Leu 
            100                 105                 110         
Lys Gly Leu Lys Asp Lys Ile Pro Tyr Phe Gln Glu Leu Gly Leu Thr 
        115                 120                 125             
Tyr Leu His Leu Met Pro Leu Phe Lys Cys Pro Glu Gly Lys Ser Asp 
    130                 135                 140                 
Gly Gly Tyr Ala Val Ser Ser Tyr Arg Asp Val Asn Pro Ala Leu Gly 
145                 150                 155                 160 
Thr Ile Gly Asp Leu Arg Glu Val Ile Ala Ala Leu His Glu Ala Gly 
                165                 170                 175     
Ile Ser Ala Val Val Asp Phe Ile Phe Asn His Thr Ser Asn Glu His 
            180                 185                 190         
Glu Trp Ala Gln Arg Cys Ala Ala Gly Asp Pro Leu Phe Asp Asn Phe 
        195                 200                 205             
Tyr Tyr Ile Phe Pro Asp Arg Arg Met Pro Asp Gln Tyr Asp Arg Thr 
    210                 215                 220                 
Leu Arg Glu Ile Xaa Pro Asp Gln His Pro Gly Gly Phe Ser Gln Leu 
225                 230                 235                 240 
Glu Asp Gly Arg Trp Val Trp Thr Thr Phe Asn Ser Phe Gln Trp Asp 
                245                 250                 255     
Leu Asn Tyr Ser Asn Pro Trp Val Phe Arg Ala Met Ala Gly Glu Met 
            260                 265                 270         
Leu Phe Leu Ala Asn Leu Gly Val Asp Ile Leu Arg Met Asp Ala Val 
        275                 280                 285             
Ala Phe Ile Trp Lys Gln Met Gly Thr Ser Cys Glu Asn Leu Pro Gln 
    290                 295                 300                 
Ala His Ala Leu Ile Arg Ala Phe Asn Ala Val Met Arg Ile Ala Ala 
305                 310                 315                 320 
Pro Ala Val Phe Phe Lys Ser Glu Ala Ile Val His Pro Asp Gln Val 
                325                 330                 335     
Val Gln Tyr Ile Gly Gln Asp Glu Cys Gln Ile Gly Tyr Asn Pro Leu 
            340                 345                 350         
Gln Met Ala Leu Leu Trp Asn Thr Leu Ala Thr Arg Glu Val Asn Leu 
        355                 360                 365             
Leu His Gln Ala Leu Thr Tyr Arg His Asn Leu Pro Glu His Thr Ala 
    370                 375                 380                 
Trp Val Asn Tyr Val Arg Ser His Asp Asp Ile Gly Trp Thr Phe Ala 
385                 390                 395                 400 
Asp Glu Asp Ala Ala Tyr Leu Gly Ile Ser Gly Tyr Asp His Arg Gln 
                405                 410                 415     
Phe Leu Asn Arg Phe Phe Val Asn Arg Phe Asp Gly Ser Phe Ala Arg 
            420                 425                 430         
Gly Val Pro Phe Gln Tyr Asn Pro Ser Thr Gly Asp Cys Arg Val Ser 
        435                 440                 445             
Gly Thr Ala Ala Ala Leu Val Gly Leu Ala Gln Asp Asp Pro His Ala 
    450                 455                 460                 
Val Asp Arg Ile Lys Leu Leu Tyr Ser Ile Ala Leu Ser Thr Gly Gly 
465                 470                 475                 480 
Leu Pro Leu Ile Tyr Leu Gly Asp Glu Val Gly Thr Leu Asn Asp Asp 
                485                 490                 495     
Asp Trp Ser Gln Asp Ser Asn Lys Ser Asp Asp Ser Arg Trp Ala His 
            500                 505                 510         
Arg Pro Arg Tyr Asn Glu Ala Leu Tyr Ala Gln Arg Asn Asp Pro Ser 
        515                 520                 525             
Thr Ala Ala Gly Gln Ile Tyr Gln Asp Leu Arg His Met Ile Ala Val 
    530                 535                 540                 
Arg Gln Ser Asn Pro Arg Phe Asp Gly Gly Arg Leu Val Thr Phe Asn 
545                 550                 555                 560 
Thr Asn Asn Lys His Ile Ile Gly Tyr Ile Arg Asn Asn Ala Leu Leu 
                565                 570                 575     
Ala Phe Gly Asn Phe Ser Glu Tyr Pro Gln Thr Val Thr Ala His Thr 
            580                 585                 590         
Leu Gln Ala Met Pro Phe Lys Ala His Asp Leu Ile Gly Gly Lys Thr 
        595                 600                 605             
Val Ser Leu Asn Gln Asp Leu Thr Leu Gln Pro Tyr Gln Val Met Trp 
    610                 615                 620                 
Leu Glu Ile Ala 
625             

<210> 4
<211> 628
<212> PRT
<213> Neisseria polysaccharea

<220> 
<221> VARIANT
<222> 289
<223> Xaa est choisi parmi C, I, N, P, V et W

<400> 4
Ser Pro Asn Ser Gln Tyr Leu Lys Thr Arg Ile Leu Asp Ile Tyr Thr 
1               5                   10                  15      
Pro Glu Gln Arg Ala Gly Ile Glu Lys Ser Glu Asp Trp Arg Gln Phe 
            20                  25                  30          
Ser Arg Arg Met Asp Thr His Phe Pro Lys Leu Met Asn Glu Leu Asp 
        35                  40                  45              
Ser Val Tyr Gly Asn Asn Glu Ala Leu Leu Pro Met Leu Glu Met Leu 
    50                  55                  60                  
Leu Ala Gln Ala Trp Gln Ser Tyr Ser Gln Arg Asn Ser Ser Leu Lys 
65                  70                  75                  80  
Asp Ile Asp Ile Ala Arg Glu Asn Asn Pro Asp Trp Ile Leu Ser Asn 
                85                  90                  95      
Lys Gln Val Gly Gly Val Cys Tyr Val Asp Leu Phe Ala Gly Asp Leu 
            100                 105                 110         
Lys Gly Leu Lys Asp Lys Ile Pro Tyr Phe Gln Glu Leu Gly Leu Thr 
        115                 120                 125             
Tyr Leu His Leu Met Pro Leu Phe Lys Cys Pro Glu Gly Lys Ser Asp 
    130                 135                 140                 
Gly Gly Tyr Ala Val Ser Ser Tyr Arg Asp Val Asn Pro Ala Leu Gly 
145                 150                 155                 160 
Thr Ile Gly Asp Leu Arg Glu Val Ile Ala Ala Leu His Glu Ala Gly 
                165                 170                 175     
Ile Ser Ala Val Val Asp Phe Ile Phe Asn His Thr Ser Asn Glu His 
            180                 185                 190         
Glu Trp Ala Gln Arg Cys Ala Ala Gly Asp Pro Leu Phe Asp Asn Phe 
        195                 200                 205             
Tyr Tyr Ile Phe Pro Asp Arg Arg Met Pro Asp Gln Tyr Asp Arg Thr 
    210                 215                 220                 
Leu Arg Glu Ile Phe Pro Asp Gln His Pro Gly Gly Phe Ser Gln Leu 
225                 230                 235                 240 
Glu Asp Gly Arg Trp Val Trp Thr Thr Phe Asn Ser Phe Gln Trp Asp 
                245                 250                 255     
Leu Asn Tyr Ser Asn Pro Trp Val Phe Arg Ala Met Ala Gly Glu Met 
            260                 265                 270         
Leu Phe Leu Ala Asn Leu Gly Val Asp Ile Leu Arg Met Asp Ala Val 
        275                 280                 285             
Xaa Phe Ile Trp Lys Gln Met Gly Thr Ser Cys Glu Asn Leu Pro Gln 
    290                 295                 300                 
Ala His Ala Leu Ile Arg Ala Phe Asn Ala Val Met Arg Ile Ala Ala 
305                 310                 315                 320 
Pro Ala Val Phe Phe Lys Ser Glu Ala Ile Val His Pro Asp Gln Val 
                325                 330                 335     
Val Gln Tyr Ile Gly Gln Asp Glu Cys Gln Ile Gly Tyr Asn Pro Leu 
            340                 345                 350         
Gln Met Ala Leu Leu Trp Asn Thr Leu Ala Thr Arg Glu Val Asn Leu 
        355                 360                 365             
Leu His Gln Ala Leu Thr Tyr Arg His Asn Leu Pro Glu His Thr Ala 
    370                 375                 380                 
Trp Val Asn Tyr Val Arg Ser His Asp Asp Ile Gly Trp Thr Phe Ala 
385                 390                 395                 400 
Asp Glu Asp Ala Ala Tyr Leu Gly Ile Ser Gly Tyr Asp His Arg Gln 
                405                 410                 415     
Phe Leu Asn Arg Phe Phe Val Asn Arg Phe Asp Gly Ser Phe Ala Arg 
            420                 425                 430         
Gly Val Pro Phe Gln Tyr Asn Pro Ser Thr Gly Asp Cys Arg Val Ser 
        435                 440                 445             
Gly Thr Ala Ala Ala Leu Val Gly Leu Ala Gln Asp Asp Pro His Ala 
    450                 455                 460                 
Val Asp Arg Ile Lys Leu Leu Tyr Ser Ile Ala Leu Ser Thr Gly Gly 
465                 470                 475                 480 
Leu Pro Leu Ile Tyr Leu Gly Asp Glu Val Gly Thr Leu Asn Asp Asp 
                485                 490                 495     
Asp Trp Ser Gln Asp Ser Asn Lys Ser Asp Asp Ser Arg Trp Ala His 
            500                 505                 510         
Arg Pro Arg Tyr Asn Glu Ala Leu Tyr Ala Gln Arg Asn Asp Pro Ser 
        515                 520                 525             
Thr Ala Ala Gly Gln Ile Tyr Gln Asp Leu Arg His Met Ile Ala Val 
    530                 535                 540                 
Arg Gln Ser Asn Pro Arg Phe Asp Gly Gly Arg Leu Val Thr Phe Asn 
545                 550                 555                 560 
Thr Asn Asn Lys His Ile Ile Gly Tyr Ile Arg Asn Asn Ala Leu Leu 
                565                 570                 575     
Ala Phe Gly Asn Phe Ser Glu Tyr Pro Gln Thr Val Thr Ala His Thr 
            580                 585                 590         
Leu Gln Ala Met Pro Phe Lys Ala His Asp Leu Ile Gly Gly Lys Thr 
        595                 600                 605             
Val Ser Leu Asn Gln Asp Leu Thr Leu Gln Pro Tyr Gln Val Met Trp 
    610                 615                 620                 
Leu Glu Ile Ala 
625             

<210> 5
<211> 628
<212> PRT
<213> Neisseria polysaccharea

<220> 
<221> VARIANT
<222> 290
<223> Xaa est choisi parmi A, C, D, G, I, K, L, M, R, V et W

<400> 5
Ser Pro Asn Ser Gln Tyr Leu Lys Thr Arg Ile Leu Asp Ile Tyr Thr 
1               5                   10                  15      
Pro Glu Gln Arg Ala Gly Ile Glu Lys Ser Glu Asp Trp Arg Gln Phe 
            20                  25                  30          
Ser Arg Arg Met Asp Thr His Phe Pro Lys Leu Met Asn Glu Leu Asp 
        35                  40                  45              
Ser Val Tyr Gly Asn Asn Glu Ala Leu Leu Pro Met Leu Glu Met Leu 
    50                  55                  60                  
Leu Ala Gln Ala Trp Gln Ser Tyr Ser Gln Arg Asn Ser Ser Leu Lys 
65                  70                  75                  80  
Asp Ile Asp Ile Ala Arg Glu Asn Asn Pro Asp Trp Ile Leu Ser Asn 
                85                  90                  95      
Lys Gln Val Gly Gly Val Cys Tyr Val Asp Leu Phe Ala Gly Asp Leu 
            100                 105                 110         
Lys Gly Leu Lys Asp Lys Ile Pro Tyr Phe Gln Glu Leu Gly Leu Thr 
        115                 120                 125             
Tyr Leu His Leu Met Pro Leu Phe Lys Cys Pro Glu Gly Lys Ser Asp 
    130                 135                 140                 
Gly Gly Tyr Ala Val Ser Ser Tyr Arg Asp Val Asn Pro Ala Leu Gly 
145                 150                 155                 160 
Thr Ile Gly Asp Leu Arg Glu Val Ile Ala Ala Leu His Glu Ala Gly 
                165                 170                 175     
Ile Ser Ala Val Val Asp Phe Ile Phe Asn His Thr Ser Asn Glu His 
            180                 185                 190         
Glu Trp Ala Gln Arg Cys Ala Ala Gly Asp Pro Leu Phe Asp Asn Phe 
        195                 200                 205             
Tyr Tyr Ile Phe Pro Asp Arg Arg Met Pro Asp Gln Tyr Asp Arg Thr 
    210                 215                 220                 
Leu Arg Glu Ile Phe Pro Asp Gln His Pro Gly Gly Phe Ser Gln Leu 
225                 230                 235                 240 
Glu Asp Gly Arg Trp Val Trp Thr Thr Phe Asn Ser Phe Gln Trp Asp 
                245                 250                 255     
Leu Asn Tyr Ser Asn Pro Trp Val Phe Arg Ala Met Ala Gly Glu Met 
            260                 265                 270         
Leu Phe Leu Ala Asn Leu Gly Val Asp Ile Leu Arg Met Asp Ala Val 
        275                 280                 285             
Ala Xaa Ile Trp Lys Gln Met Gly Thr Ser Cys Glu Asn Leu Pro Gln 
    290                 295                 300                 
Ala His Ala Leu Ile Arg Ala Phe Asn Ala Val Met Arg Ile Ala Ala 
305                 310                 315                 320 
Pro Ala Val Phe Phe Lys Ser Glu Ala Ile Val His Pro Asp Gln Val 
                325                 330                 335     
Val Gln Tyr Ile Gly Gln Asp Glu Cys Gln Ile Gly Tyr Asn Pro Leu 
            340                 345                 350         
Gln Met Ala Leu Leu Trp Asn Thr Leu Ala Thr Arg Glu Val Asn Leu 
        355                 360                 365             
Leu His Gln Ala Leu Thr Tyr Arg His Asn Leu Pro Glu His Thr Ala 
    370                 375                 380                 
Trp Val Asn Tyr Val Arg Ser His Asp Asp Ile Gly Trp Thr Phe Ala 
385                 390                 395                 400 
Asp Glu Asp Ala Ala Tyr Leu Gly Ile Ser Gly Tyr Asp His Arg Gln 
                405                 410                 415     
Phe Leu Asn Arg Phe Phe Val Asn Arg Phe Asp Gly Ser Phe Ala Arg 
            420                 425                 430         
Gly Val Pro Phe Gln Tyr Asn Pro Ser Thr Gly Asp Cys Arg Val Ser 
        435                 440                 445             
Gly Thr Ala Ala Ala Leu Val Gly Leu Ala Gln Asp Asp Pro His Ala 
    450                 455                 460                 
Val Asp Arg Ile Lys Leu Leu Tyr Ser Ile Ala Leu Ser Thr Gly Gly 
465                 470                 475                 480 
Leu Pro Leu Ile Tyr Leu Gly Asp Glu Val Gly Thr Leu Asn Asp Asp 
                485                 490                 495     
Asp Trp Ser Gln Asp Ser Asn Lys Ser Asp Asp Ser Arg Trp Ala His 
            500                 505                 510         
Arg Pro Arg Tyr Asn Glu Ala Leu Tyr Ala Gln Arg Asn Asp Pro Ser 
        515                 520                 525             
Thr Ala Ala Gly Gln Ile Tyr Gln Asp Leu Arg His Met Ile Ala Val 
    530                 535                 540                 
Arg Gln Ser Asn Pro Arg Phe Asp Gly Gly Arg Leu Val Thr Phe Asn 
545                 550                 555                 560 
Thr Asn Asn Lys His Ile Ile Gly Tyr Ile Arg Asn Asn Ala Leu Leu 
                565                 570                 575     
Ala Phe Gly Asn Phe Ser Glu Tyr Pro Gln Thr Val Thr Ala His Thr 
            580                 585                 590         
Leu Gln Ala Met Pro Phe Lys Ala His Asp Leu Ile Gly Gly Lys Thr 
        595                 600                 605             
Val Ser Leu Asn Gln Asp Leu Thr Leu Gln Pro Tyr Gln Val Met Trp 
    610                 615                 620                 
Leu Glu Ile Ala 
625             

<210> 6
<211> 628
<212> PRT
<213> Neisseria polysaccharea

<220> 
<221> VARIANT
<222> 331
<223> Xaa est choisi parmi C, G, Q, S et T

<400> 6
Ser Pro Asn Ser Gln Tyr Leu Lys Thr Arg Ile Leu Asp Ile Tyr Thr 
1               5                   10                  15      
Pro Glu Gln Arg Ala Gly Ile Glu Lys Ser Glu Asp Trp Arg Gln Phe 
            20                  25                  30          
Ser Arg Arg Met Asp Thr His Phe Pro Lys Leu Met Asn Glu Leu Asp 
        35                  40                  45              
Ser Val Tyr Gly Asn Asn Glu Ala Leu Leu Pro Met Leu Glu Met Leu 
    50                  55                  60                  
Leu Ala Gln Ala Trp Gln Ser Tyr Ser Gln Arg Asn Ser Ser Leu Lys 
65                  70                  75                  80  
Asp Ile Asp Ile Ala Arg Glu Asn Asn Pro Asp Trp Ile Leu Ser Asn 
                85                  90                  95      
Lys Gln Val Gly Gly Val Cys Tyr Val Asp Leu Phe Ala Gly Asp Leu 
            100                 105                 110         
Lys Gly Leu Lys Asp Lys Ile Pro Tyr Phe Gln Glu Leu Gly Leu Thr 
        115                 120                 125             
Tyr Leu His Leu Met Pro Leu Phe Lys Cys Pro Glu Gly Lys Ser Asp 
    130                 135                 140                 
Gly Gly Tyr Ala Val Ser Ser Tyr Arg Asp Val Asn Pro Ala Leu Gly 
145                 150                 155                 160 
Thr Ile Gly Asp Leu Arg Glu Val Ile Ala Ala Leu His Glu Ala Gly 
                165                 170                 175     
Ile Ser Ala Val Val Asp Phe Ile Phe Asn His Thr Ser Asn Glu His 
            180                 185                 190         
Glu Trp Ala Gln Arg Cys Ala Ala Gly Asp Pro Leu Phe Asp Asn Phe 
        195                 200                 205             
Tyr Tyr Ile Phe Pro Asp Arg Arg Met Pro Asp Gln Tyr Asp Arg Thr 
    210                 215                 220                 
Leu Arg Glu Ile Phe Pro Asp Gln His Pro Gly Gly Phe Ser Gln Leu 
225                 230                 235                 240 
Glu Asp Gly Arg Trp Val Trp Thr Thr Phe Asn Ser Phe Gln Trp Asp 
                245                 250                 255     
Leu Asn Tyr Ser Asn Pro Trp Val Phe Arg Ala Met Ala Gly Glu Met 
            260                 265                 270         
Leu Phe Leu Ala Asn Leu Gly Val Asp Ile Leu Arg Met Asp Ala Val 
        275                 280                 285             
Ala Phe Ile Trp Lys Gln Met Gly Thr Ser Cys Glu Asn Leu Pro Gln 
    290                 295                 300                 
Ala His Ala Leu Ile Arg Ala Phe Asn Ala Val Met Arg Ile Ala Ala 
305                 310                 315                 320 
Pro Ala Val Phe Phe Lys Ser Glu Ala Ile Xaa His Pro Asp Gln Val 
                325                 330                 335     
Val Gln Tyr Ile Gly Gln Asp Glu Cys Gln Ile Gly Tyr Asn Pro Leu 
            340                 345                 350         
Gln Met Ala Leu Leu Trp Asn Thr Leu Ala Thr Arg Glu Val Asn Leu 
        355                 360                 365             
Leu His Gln Ala Leu Thr Tyr Arg His Asn Leu Pro Glu His Thr Ala 
    370                 375                 380                 
Trp Val Asn Tyr Val Arg Ser His Asp Asp Ile Gly Trp Thr Phe Ala 
385                 390                 395                 400 
Asp Glu Asp Ala Ala Tyr Leu Gly Ile Ser Gly Tyr Asp His Arg Gln 
                405                 410                 415     
Phe Leu Asn Arg Phe Phe Val Asn Arg Phe Asp Gly Ser Phe Ala Arg 
            420                 425                 430         
Gly Val Pro Phe Gln Tyr Asn Pro Ser Thr Gly Asp Cys Arg Val Ser 
        435                 440                 445             
Gly Thr Ala Ala Ala Leu Val Gly Leu Ala Gln Asp Asp Pro His Ala 
    450                 455                 460                 
Val Asp Arg Ile Lys Leu Leu Tyr Ser Ile Ala Leu Ser Thr Gly Gly 
465                 470                 475                 480 
Leu Pro Leu Ile Tyr Leu Gly Asp Glu Val Gly Thr Leu Asn Asp Asp 
                485                 490                 495     
Asp Trp Ser Gln Asp Ser Asn Lys Ser Asp Asp Ser Arg Trp Ala His 
            500                 505                 510         
Arg Pro Arg Tyr Asn Glu Ala Leu Tyr Ala Gln Arg Asn Asp Pro Ser 
        515                 520                 525             
Thr Ala Ala Gly Gln Ile Tyr Gln Asp Leu Arg His Met Ile Ala Val 
    530                 535                 540                 
Arg Gln Ser Asn Pro Arg Phe Asp Gly Gly Arg Leu Val Thr Phe Asn 
545                 550                 555                 560 
Thr Asn Asn Lys His Ile Ile Gly Tyr Ile Arg Asn Asn Ala Leu Leu 
                565                 570                 575     
Ala Phe Gly Asn Phe Ser Glu Tyr Pro Gln Thr Val Thr Ala His Thr 
            580                 585                 590         
Leu Gln Ala Met Pro Phe Lys Ala His Asp Leu Ile Gly Gly Lys Thr 
        595                 600                 605             
Val Ser Leu Asn Gln Asp Leu Thr Leu Gln Pro Tyr Gln Val Met Trp 
    610                 615                 620                 
Leu Glu Ile Ala 
625             

<210> 7
<211> 628
<212> PRT
<213> Neisseria polysaccharea

<220> 
<221> VARIANT
<222> 394
<223> Xaa est choisi parmi A et G

<400> 7
Ser Pro Asn Ser Gln Tyr Leu Lys Thr Arg Ile Leu Asp Ile Tyr Thr 
1               5                   10                  15      
Pro Glu Gln Arg Ala Gly Ile Glu Lys Ser Glu Asp Trp Arg Gln Phe 
            20                  25                  30          
Ser Arg Arg Met Asp Thr His Phe Pro Lys Leu Met Asn Glu Leu Asp 
        35                  40                  45              
Ser Val Tyr Gly Asn Asn Glu Ala Leu Leu Pro Met Leu Glu Met Leu 
    50                  55                  60                  
Leu Ala Gln Ala Trp Gln Ser Tyr Ser Gln Arg Asn Ser Ser Leu Lys 
65                  70                  75                  80  
Asp Ile Asp Ile Ala Arg Glu Asn Asn Pro Asp Trp Ile Leu Ser Asn 
                85                  90                  95      
Lys Gln Val Gly Gly Val Cys Tyr Val Asp Leu Phe Ala Gly Asp Leu 
            100                 105                 110         
Lys Gly Leu Lys Asp Lys Ile Pro Tyr Phe Gln Glu Leu Gly Leu Thr 
        115                 120                 125             
Tyr Leu His Leu Met Pro Leu Phe Lys Cys Pro Glu Gly Lys Ser Asp 
    130                 135                 140                 
Gly Gly Tyr Ala Val Ser Ser Tyr Arg Asp Val Asn Pro Ala Leu Gly 
145                 150                 155                 160 
Thr Ile Gly Asp Leu Arg Glu Val Ile Ala Ala Leu His Glu Ala Gly 
                165                 170                 175     
Ile Ser Ala Val Val Asp Phe Ile Phe Asn His Thr Ser Asn Glu His 
            180                 185                 190         
Glu Trp Ala Gln Arg Cys Ala Ala Gly Asp Pro Leu Phe Asp Asn Phe 
        195                 200                 205             
Tyr Tyr Ile Phe Pro Asp Arg Arg Met Pro Asp Gln Tyr Asp Arg Thr 
    210                 215                 220                 
Leu Arg Glu Ile Phe Pro Asp Gln His Pro Gly Gly Phe Ser Gln Leu 
225                 230                 235                 240 
Glu Asp Gly Arg Trp Val Trp Thr Thr Phe Asn Ser Phe Gln Trp Asp 
                245                 250                 255     
Leu Asn Tyr Ser Asn Pro Trp Val Phe Arg Ala Met Ala Gly Glu Met 
            260                 265                 270         
Leu Phe Leu Ala Asn Leu Gly Val Asp Ile Leu Arg Met Asp Ala Val 
        275                 280                 285             
Ala Phe Ile Trp Lys Gln Met Gly Thr Ser Cys Glu Asn Leu Pro Gln 
    290                 295                 300                 
Ala His Ala Leu Ile Arg Ala Phe Asn Ala Val Met Arg Ile Ala Ala 
305                 310                 315                 320 
Pro Ala Val Phe Phe Lys Ser Glu Ala Ile Val His Pro Asp Gln Val 
                325                 330                 335     
Val Gln Tyr Ile Gly Gln Asp Glu Cys Gln Ile Gly Tyr Asn Pro Leu 
            340                 345                 350         
Gln Met Ala Leu Leu Trp Asn Thr Leu Ala Thr Arg Glu Val Asn Leu 
        355                 360                 365             
Leu His Gln Ala Leu Thr Tyr Arg His Asn Leu Pro Glu His Thr Ala 
    370                 375                 380                 
Trp Val Asn Tyr Val Arg Ser His Asp Xaa Ile Gly Trp Thr Phe Ala 
385                 390                 395                 400 
Asp Glu Asp Ala Ala Tyr Leu Gly Ile Ser Gly Tyr Asp His Arg Gln 
                405                 410                 415     
Phe Leu Asn Arg Phe Phe Val Asn Arg Phe Asp Gly Ser Phe Ala Arg 
            420                 425                 430         
Gly Val Pro Phe Gln Tyr Asn Pro Ser Thr Gly Asp Cys Arg Val Ser 
        435                 440                 445             
Gly Thr Ala Ala Ala Leu Val Gly Leu Ala Gln Asp Asp Pro His Ala 
    450                 455                 460                 
Val Asp Arg Ile Lys Leu Leu Tyr Ser Ile Ala Leu Ser Thr Gly Gly 
465                 470                 475                 480 
Leu Pro Leu Ile Tyr Leu Gly Asp Glu Val Gly Thr Leu Asn Asp Asp 
                485                 490                 495     
Asp Trp Ser Gln Asp Ser Asn Lys Ser Asp Asp Ser Arg Trp Ala His 
            500                 505                 510         
Arg Pro Arg Tyr Asn Glu Ala Leu Tyr Ala Gln Arg Asn Asp Pro Ser 
        515                 520                 525             
Thr Ala Ala Gly Gln Ile Tyr Gln Asp Leu Arg His Met Ile Ala Val 
    530                 535                 540                 
Arg Gln Ser Asn Pro Arg Phe Asp Gly Gly Arg Leu Val Thr Phe Asn 
545                 550                 555                 560 
Thr Asn Asn Lys His Ile Ile Gly Tyr Ile Arg Asn Asn Ala Leu Leu 
                565                 570                 575     
Ala Phe Gly Asn Phe Ser Glu Tyr Pro Gln Thr Val Thr Ala His Thr 
            580                 585                 590         
Leu Gln Ala Met Pro Phe Lys Ala His Asp Leu Ile Gly Gly Lys Thr 
        595                 600                 605             
Val Ser Leu Asn Gln Asp Leu Thr Leu Gln Pro Tyr Gln Val Met Trp 
    610                 615                 620                 
Leu Glu Ile Ala 
625             

<210> 8
<211> 628
<212> PRT
<213> Neisseria polysaccharea

<400> 8
Ser Pro Asn Ser Gln Tyr Leu Lys Thr Arg Ile Leu Asp Ile Tyr Thr 
1               5                   10                  15      
Pro Glu Gln Arg Ala Gly Ile Glu Lys Ser Glu Asp Trp Arg Gln Phe 
            20                  25                  30          
Ser Arg Arg Met Asp Thr His Phe Pro Lys Leu Met Asn Glu Leu Asp 
        35                  40                  45              
Ser Val Tyr Gly Asn Asn Glu Ala Leu Leu Pro Met Leu Glu Met Leu 
    50                  55                  60                  
Leu Ala Gln Ala Trp Gln Ser Tyr Ser Gln Arg Asn Ser Ser Leu Lys 
65                  70                  75                  80  
Asp Ile Asp Ile Ala Arg Glu Asn Asn Pro Asp Trp Ile Leu Ser Asn 
                85                  90                  95      
Lys Gln Val Gly Gly Val Cys Tyr Val Asp Leu Phe Ala Gly Asp Leu 
            100                 105                 110         
Lys Gly Leu Lys Asp Lys Ile Pro Tyr Phe Gln Glu Leu Gly Leu Thr 
        115                 120                 125             
Tyr Leu His Leu Met Pro Leu Phe Lys Cys Pro Glu Gly Lys Ser Asp 
    130                 135                 140                 
Gly Gly Tyr Ala Val Ser Ser Tyr Arg Asp Val Asn Pro Ala Leu Gly 
145                 150                 155                 160 
Thr Ile Gly Asp Leu Arg Glu Val Ile Ala Ala Leu His Glu Ala Gly 
                165                 170                 175     
Ile Ser Ala Val Val Asp Phe Ile Phe Asn His Thr Ser Asn Glu His 
            180                 185                 190         
Glu Trp Ala Gln Arg Cys Ala Ala Gly Asp Pro Leu Phe Asp Asn Phe 
        195                 200                 205             
Tyr Tyr Ile Phe Pro Asp Arg Arg Met Pro Asp Gln Tyr Asp Arg Thr 
    210                 215                 220                 
Leu Arg Glu Ile Phe Pro Asp Gln His Pro Gly Gly Phe Ser Gln Leu 
225                 230                 235                 240 
Glu Asp Gly Arg Trp Val Trp Thr Thr Phe Asn Ser Phe Gln Trp Asp 
                245                 250                 255     
Leu Asn Tyr Ser Asn Pro Trp Val Phe Arg Ala Met Ala Gly Glu Met 
            260                 265                 270         
Leu Phe Leu Ala Asn Leu Gly Val Asp Ile Leu Arg Met Asp Ala Val 
        275                 280                 285             
Ala Phe Ile Trp Lys Gln Met Gly Thr Ser Cys Glu Asn Leu Pro Gln 
    290                 295                 300                 
Ala His Ala Leu Ile Arg Ala Phe Asn Ala Val Met Arg Ile Ala Ala 
305                 310                 315                 320 
Pro Ala Val Phe Phe Lys Ser Glu Ala Ile Val His Pro Asp Gln Val 
                325                 330                 335     
Val Gln Tyr Ile Gly Gln Asp Glu Cys Gln Ile Gly Tyr Asn Pro Leu 
            340                 345                 350         
Gln Met Ala Leu Leu Trp Asn Thr Leu Ala Thr Arg Glu Val Asn Leu 
        355                 360                 365             
Leu His Gln Ala Leu Thr Tyr Arg His Asn Leu Pro Glu His Thr Ala 
    370                 375                 380                 
Trp Val Asn Tyr Val Arg Ser His Asp Asp Ile Gly Trp Thr Phe Ala 
385                 390                 395                 400 
Asp Glu Asp Ala Ala Tyr Leu Gly Ile Ser Gly Tyr Asp His Arg Gln 
                405                 410                 415     
Phe Leu Asn Arg Phe Phe Val Asn Arg Phe Asp Gly Ser Phe Ala Arg 
            420                 425                 430         
Gly Val Pro Phe Gln Tyr Asn Pro Ser Thr Gly Asp Cys Gln Val Ser 
        435                 440                 445             
Gly Thr Ala Ala Ala Leu Val Gly Leu Ala Gln Asp Asp Pro His Ala 
    450                 455                 460                 
Val Asp Arg Ile Lys Leu Leu Tyr Ser Ile Ala Leu Ser Thr Gly Gly 
465                 470                 475                 480 
Leu Pro Leu Ile Tyr Leu Gly Asp Glu Val Gly Thr Leu Asn Asp Asp 
                485                 490                 495     
Asp Trp Ser Gln Asp Ser Asn Lys Ser Asp Asp Ser Arg Trp Ala His 
            500                 505                 510         
Arg Pro Arg Tyr Asn Glu Ala Leu Tyr Ala Gln Arg Asn Asp Pro Ser 
        515                 520                 525             
Thr Ala Ala Gly Gln Ile Tyr Gln Asp Leu Arg His Met Ile Ala Val 
    530                 535                 540                 
Arg Gln Ser Asn Pro Arg Phe Asp Gly Gly Arg Leu Val Thr Phe Asn 
545                 550                 555                 560 
Thr Asn Asn Lys His Ile Ile Gly Tyr Ile Arg Asn Asn Ala Leu Leu 
                565                 570                 575     
Ala Phe Gly Asn Phe Ser Glu Tyr Pro Gln Thr Val Thr Ala His Thr 
            580                 585                 590         
Leu Gln Ala Met Pro Phe Lys Ala His Asp Leu Ile Gly Gly Lys Thr 
        595                 600                 605             
Val Ser Leu Asn Gln Asp Leu Thr Leu Gln Pro Tyr Gln Val Met Trp 
    610                 615                 620                 
Leu Glu Ile Ala 
625             

<210> 9
<211> 628
<212> PRT
<213> Neisseria polysaccharea

<220> 
<221> VARIANT
<222> 290
<223> Xaa est choisi parmi C, I et L

<400> 9
Ser Pro Asn Ser Gln Tyr Leu Lys Thr Arg Ile Leu Asp Ile Tyr Thr 
1               5                   10                  15      
Pro Glu Gln Arg Ala Gly Ile Glu Lys Ser Glu Asp Trp Arg Gln Phe 
            20                  25                  30          
Ser Arg Arg Met Asp Thr His Phe Pro Lys Leu Met Asn Glu Leu Asp 
        35                  40                  45              
Ser Val Tyr Gly Asn Asn Glu Ala Leu Leu Pro Met Leu Glu Met Leu 
    50                  55                  60                  
Leu Ala Gln Ala Trp Gln Ser Tyr Ser Gln Arg Asn Ser Ser Leu Lys 
65                  70                  75                  80  
Asp Ile Asp Ile Ala Arg Glu Asn Asn Pro Asp Trp Ile Leu Ser Asn 
                85                  90                  95      
Lys Gln Val Gly Gly Val Cys Tyr Val Asp Leu Phe Ala Gly Asp Leu 
            100                 105                 110         
Lys Gly Leu Lys Asp Lys Ile Pro Tyr Phe Gln Glu Leu Gly Leu Thr 
        115                 120                 125             
Tyr Leu His Leu Met Pro Leu Phe Lys Cys Pro Glu Gly Lys Ser Asp 
    130                 135                 140                 
Gly Gly Tyr Ala Val Ser Ser Tyr Arg Asp Val Asn Pro Ala Leu Gly 
145                 150                 155                 160 
Thr Ile Gly Asp Leu Arg Glu Val Ile Ala Ala Leu His Glu Ala Gly 
                165                 170                 175     
Ile Ser Ala Val Val Asp Phe Ile Phe Asn His Thr Ser Asn Glu His 
            180                 185                 190         
Glu Trp Ala Gln Arg Cys Ala Ala Gly Asp Pro Leu Phe Asp Asn Phe 
        195                 200                 205             
Tyr Tyr Ile Phe Pro Asp Arg Arg Met Pro Asp Gln Tyr Asp Arg Thr 
    210                 215                 220                 
Leu Arg Glu Ile Phe Pro Asp Gln His Pro Gly Gly Phe Ser Gln Leu 
225                 230                 235                 240 
Glu Asp Gly Arg Trp Val Trp Thr Thr Phe Asn Ser Phe Gln Trp Asp 
                245                 250                 255     
Leu Asn Tyr Ser Asn Pro Trp Val Phe Arg Ala Met Ala Gly Glu Met 
            260                 265                 270         
Leu Phe Leu Ala Asn Leu Gly Val Asp Ile Leu Arg Met Asp Ala Val 
        275                 280                 285             
Pro Xaa Ile Trp Lys Gln Met Gly Thr Ser Cys Glu Asn Leu Pro Gln 
    290                 295                 300                 
Ala His Ala Leu Ile Arg Ala Phe Asn Ala Val Met Arg Ile Ala Ala 
305                 310                 315                 320 
Pro Ala Val Phe Phe Lys Ser Glu Ala Ile Val His Pro Asp Gln Val 
                325                 330                 335     
Val Gln Tyr Ile Gly Gln Asp Glu Cys Gln Ile Gly Tyr Asn Pro Leu 
            340                 345                 350         
Gln Met Ala Leu Leu Trp Asn Thr Leu Ala Thr Arg Glu Val Asn Leu 
        355                 360                 365             
Leu His Gln Ala Leu Thr Tyr Arg His Asn Leu Pro Glu His Thr Ala 
    370                 375                 380                 
Trp Val Asn Tyr Val Arg Ser His Asp Asp Ile Gly Trp Thr Phe Ala 
385                 390                 395                 400 
Asp Glu Asp Ala Ala Tyr Leu Gly Ile Ser Gly Tyr Asp His Arg Gln 
                405                 410                 415     
Phe Leu Asn Arg Phe Phe Val Asn Arg Phe Asp Gly Ser Phe Ala Arg 
            420                 425                 430         
Gly Val Pro Phe Gln Tyr Asn Pro Ser Thr Gly Asp Cys Arg Val Ser 
        435                 440                 445             
Gly Thr Ala Ala Ala Leu Val Gly Leu Ala Gln Asp Asp Pro His Ala 
    450                 455                 460                 
Val Asp Arg Ile Lys Leu Leu Tyr Ser Ile Ala Leu Ser Thr Gly Gly 
465                 470                 475                 480 
Leu Pro Leu Ile Tyr Leu Gly Asp Glu Val Gly Thr Leu Asn Asp Asp 
                485                 490                 495     
Asp Trp Ser Gln Asp Ser Asn Lys Ser Asp Asp Ser Arg Trp Ala His 
            500                 505                 510         
Arg Pro Arg Tyr Asn Glu Ala Leu Tyr Ala Gln Arg Asn Asp Pro Ser 
        515                 520                 525             
Thr Ala Ala Gly Gln Ile Tyr Gln Asp Leu Arg His Met Ile Ala Val 
    530                 535                 540                 
Arg Gln Ser Asn Pro Arg Phe Asp Gly Gly Arg Leu Val Thr Phe Asn 
545                 550                 555                 560 
Thr Asn Asn Lys His Ile Ile Gly Tyr Ile Arg Asn Asn Ala Leu Leu 
                565                 570                 575     
Ala Phe Gly Asn Phe Ser Glu Tyr Pro Gln Thr Val Thr Ala His Thr 
            580                 585                 590         
Leu Gln Ala Met Pro Phe Lys Ala His Asp Leu Ile Gly Gly Lys Thr 
        595                 600                 605             
Val Ser Leu Asn Gln Asp Leu Thr Leu Gln Pro Tyr Gln Val Met Trp 
    610                 615                 620                 
Leu Glu Ile Ala 
625             

<210> 10
<211> 1299
<212> PRT
<213> Leuconostoc mesenteroides

<400> 10
Thr Gln Gln Val Ser Gly Lys Tyr Val Glu Lys Asp Gly Ser Trp Tyr 
1               5                   10                  15      
Tyr Tyr Phe Asp Asp Gly Lys Asn Ala Lys Gly Leu Ser Thr Ile Asp 
            20                  25                  30          
Asn Asn Ile Gln Tyr Phe Tyr Glu Ser Gly Lys Gln Ala Lys Gly Gln 
        35                  40                  45              
Tyr Val Thr Ile Asp Asn Gln Thr Tyr Tyr Phe Asp Lys Gly Ser Gly 
    50                  55                  60                  
Asp Glu Leu Thr Gly Leu Gln Ser Ile Asp Gly Asn Ile Val Ala Phe 
65                  70                  75                  80  
Asn Asp Glu Gly Gln Gln Ile Phe Asn Gln Tyr Tyr Gln Ser Glu Asn 
                85                  90                  95      
Gly Thr Thr Tyr Tyr Phe Asp Asp Lys Gly His Ala Ala Thr Gly Ile 
            100                 105                 110         
Lys Asn Ile Glu Gly Lys Asn Tyr Tyr Phe Asp Asn Leu Gly Gln Leu 
        115                 120                 125             
Lys Lys Gly Phe Ser Gly Val Ile Asp Gly Gln Ile Met Thr Phe Asp 
    130                 135                 140                 
Gln Glu Thr Gly Gln Glu Val Ser Asn Thr Thr Ser Glu Ile Lys Glu 
145                 150                 155                 160 
Gly Leu Thr Thr Gln Asn Thr Asp Tyr Ser Glu His Asn Ala Ala His 
                165                 170                 175     
Gly Thr Asp Ala Glu Asp Phe Glu Asn Ile Asp Gly Tyr Leu Thr Ala 
            180                 185                 190         
Ser Ser Trp Tyr Arg Pro Thr Gly Ile Leu Arg Asn Gly Thr Asp Trp 
        195                 200                 205             
Glu Pro Ser Thr Asp Thr Asp Phe Arg Pro Ile Leu Ser Val Trp Trp 
    210                 215                 220                 
Pro Asp Lys Asn Thr Gln Val Asn Tyr Leu Asn Tyr Met Ala Asp Leu 
225                 230                 235                 240 
Gly Phe Ile Ser Asn Ala Asp Ser Phe Glu Thr Gly Asp Ser Gln Ser 
                245                 250                 255     
Leu Leu Asn Glu Ala Ser Asn Tyr Val Gln Lys Ser Ile Glu Met Lys 
            260                 265                 270         
Ile Ser Ala Gln Gln Ser Thr Glu Trp Leu Lys Asp Ala Met Ala Ala 
        275                 280                 285             
Phe Ile Val Ala Gln Pro Gln Trp Asn Glu Thr Ser Glu Asp Met Ser 
    290                 295                 300                 
Asn Asp His Leu Gln Asn Gly Ala Leu Thr Tyr Val Asn Ser Pro Leu 
305                 310                 315                 320 
Thr Pro Asp Ala Asn Ser Asn Phe Arg Leu Leu Asn Arg Thr Pro Thr 
                325                 330                 335     
Asn Gln Thr Gly Glu Gln Ala Tyr Asn Leu Asp Asn Ser Lys Gly Gly 
            340                 345                 350         
Phe Glu Leu Leu Leu Ala Asn Gln Glu Asp Asn Ser Asn Val Val Val 
        355                 360                 365             
Glu Ala Glu Gln Leu Asn Trp Leu Tyr Tyr Leu Met Asn Phe Gly Thr 
    370                 375                 380                 
Ile Thr Ala Asn Asp Ala Asp Ala Asn Phe Asp Gly Ile Arg Val Asp 
385                 390                 395                 400 
Ala Val Asp Asn Val Asp Ala Asp Leu Leu Gln Ile Ala Ala Asp Tyr 
                405                 410                 415     
Phe Lys Leu Ala Tyr Gly Val Asp Gln Asn Asp Ala Thr Ala Asn Gln 
            420                 425                 430         
His Leu Ser Ile Leu Glu Asp Trp Ser His Asn Asp Pro Leu Tyr Val 
        435                 440                 445             
Thr Asp Gln Gly Ser Asn Gln Leu Thr Met Asp Asp Tyr Val His Thr 
    450                 455                 460                 
Gln Leu Ile Trp Ser Leu Thr Lys Ser Ser Asp Ile Arg Gly Thr Met 
465                 470                 475                 480 
Gln Arg Phe Val Asp Tyr Tyr Met Val Asp Arg Ser Asn Asp Ser Thr 
                485                 490                 495     
Glu Asn Glu Ala Ile Pro Asn Tyr Ser Phe Val Arg Ala His Asp Cys 
            500                 505                 510         
Glu Val Gln Thr Val Ile Ala Gln Ile Val Ser Asp Leu Tyr Pro Asp 
        515                 520                 525             
Val Glu Asn Ser Leu Ala Pro Thr Thr Glu Gln Leu Ala Ala Ala Phe 
    530                 535                 540                 
Lys Val Tyr Asn Glu Asp Glu Lys Leu Ala Asp Lys Lys Tyr Thr Gln 
545                 550                 555                 560 
Tyr Asn Met Ala Ser Ala Tyr Ala Met Leu Leu Thr Asn Lys Asp Thr 
                565                 570                 575     
Val Pro Arg Val Tyr Tyr Gly Asp Leu Tyr Thr Asp Asp Gly Gln Tyr 
            580                 585                 590         
Met Ala Thr Lys Ser Pro Tyr Tyr Asp Ala Ile Asn Thr Leu Leu Lys 
        595                 600                 605             
Ala Arg Val Gln Tyr Val Ala Gly Gly Gln Ser Met Ser Val Asp Ser 
    610                 615                 620                 
Asn Asp Val Leu Thr Ser Val Arg Tyr Gly Lys Asp Ala Met Thr Ala 
625                 630                 635                 640 
Ser Asp Thr Gly Thr Ser Glu Thr Arg Thr Glu Gly Ile Gly Val Ile 
                645                 650                 655     
Val Ser Asn Asn Ala Glu Leu Gln Leu Glu Asp Gly His Thr Val Thr 
            660                 665                 670         
Leu His Met Gly Ala Ala His Lys Asn Gln Ala Tyr Arg Ala Leu Leu 
        675                 680                 685             
Ser Thr Thr Ala Asp Gly Leu Ala Tyr Tyr Asp Thr Asp Glu Asn Ala 
    690                 695                 700                 
Pro Val Ala Tyr Thr Asp Ala Asn Gly Asp Leu Ile Phe Thr Asn Glu 
705                 710                 715                 720 
Ser Ile Tyr Gly Val Gln Asn Pro Gln Val Ser Gly Tyr Leu Ala Val 
                725                 730                 735     
Trp Val Pro Val Gly Ala Gln Gln Asp Gln Asp Ala Arg Thr Ala Ser 
            740                 745                 750         
Asp Thr Thr Thr Asn Thr Ser Asp Lys Val Phe His Ser Asn Ala Ala 
        755                 760                 765             
Leu Asp Ser Gln Val Ile Tyr Glu Gly Phe Ser Asn Phe Gln Ala Phe 
    770                 775                 780                 
Ala Thr Asp Ser Ser Glu Tyr Thr Asn Val Val Ile Ala Gln Asn Ala 
785                 790                 795                 800 
Asp Gln Phe Lys Gln Trp Gly Val Thr Ser Phe Gln Leu Ala Pro Gln 
                805                 810                 815     
Tyr Arg Ser Ser Thr Asp Thr Ser Phe Leu Asp Ser Ile Ile Gln Asn 
            820                 825                 830         
Gly Tyr Ala Phe Thr Asp Arg Tyr Asp Leu Gly Tyr Gly Thr Pro Thr 
        835                 840                 845             
Lys Tyr Gly Thr Ala Asp Gln Leu Arg Asp Ala Ile Lys Ala Leu His 
    850                 855                 860                 
Ala Ser Gly Ile Gln Ala Ile Ala Asp Trp Val Pro Asp Gln Ile Tyr 
865                 870                 875                 880 
Asn Leu Pro Glu Gln Glu Leu Ala Thr Val Thr Arg Thr Asn Ser Phe 
                885                 890                 895     
Gly Asp Asp Asp Thr Asp Ser Asp Ile Asp Asn Ala Leu Tyr Val Val 
            900                 905                 910         
Gln Ser Arg Gly Gly Gly Gln Tyr Gln Glu Met Tyr Gly Gly Ala Phe 
        915                 920                 925             
Leu Glu Glu Leu Gln Ala Leu Tyr Pro Ser Leu Phe Lys Val Asn Gln 
    930                 935                 940                 
Ile Ser Thr Gly Val Pro Ile Asp Gly Ser Val Lys Ile Thr Glu Trp 
945                 950                 955                 960 
Ala Ala Lys Tyr Phe Asn Gly Ser Asn Ile Gln Gly Lys Gly Ala Gly 
                965                 970                 975     
Tyr Val Leu Lys Asp Met Gly Ser Asn Lys Tyr Phe Lys Val Val Ser 
            980                 985                 990         
Asn Thr Glu Asp Gly Asp Tyr Leu Pro Lys Gln Leu Thr Asn Asp Leu 
        995                 1000                1005            
Ser Glu Thr Gly Phe Thr His Asp Asp Lys Gly Ile Ile Tyr Tyr Thr 
    1010                1015                1020                
Leu Ser Gly Tyr Arg Ala Gln Asn Ala Phe Ile Gln Asp Asp Asp Asn 
1025                1030                1035                1040
Asn Tyr Tyr Tyr Phe Asp Lys Thr Gly His Leu Val Thr Gly Leu Gln 
                1045                1050                1055    
Lys Ile Asn Asn His Thr Tyr Phe Phe Leu Pro Asn Gly Ile Glu Leu 
            1060                1065                1070        
Val Lys Ser Phe Leu Gln Asn Glu Asp Gly Thr Ile Val Tyr Phe Asp 
        1075                1080                1085            
Lys Lys Gly His Gln Val Phe Asp Gln Tyr Ile Thr Asp Gln Asn Gly 
    1090                1095                1100                
Asn Ala Tyr Tyr Phe Asp Asp Ala Gly Val Met Leu Lys Ser Gly Leu 
1105                1110                1115                1120
Ala Thr Ile Asp Gly His Gln Gln Tyr Phe Asp Gln Asn Gly Val Gln 
                1125                1130                1135    
Val Lys Asp Lys Phe Val Ile Gly Thr Asp Gly Tyr Lys Tyr Tyr Phe 
            1140                1145                1150        
Glu Pro Gly Ser Gly Asn Leu Ala Ile Leu Arg Tyr Val Gln Asn Ser 
        1155                1160                1165            
Lys Asn Gln Trp Phe Tyr Phe Asp Gly Asn Gly His Ala Val Thr Gly 
    1170                1175                1180                
Phe Gln Thr Ile Asn Gly Lys Lys Gln Tyr Phe Tyr Asn Asp Gly His 
1185                1190                1195                1200
Gln Ser Lys Gly Glu Phe Ile Asp Ala Asp Gly Asp Thr Phe Tyr Thr 
                1205                1210                1215    
Ser Ala Thr Asp Gly Arg Leu Val Thr Gly Val Gln Lys Ile Asn Gly 
            1220                1225                1230        
Ile Thr Tyr Ala Phe Asp Asn Thr Gly Asn Leu Ile Thr Asn Gln Tyr 
        1235                1240                1245            
Tyr Gln Leu Ala Asp Gly Lys Tyr Met Leu Leu Asp Asp Ser Gly Arg 
    1250                1255                1260                
Ala Lys Thr Gly Phe Val Leu Gln Asp Gly Val Leu Arg Tyr Phe Asp 
1265                1270                1275                1280
Gln Asn Gly Glu Gln Val Lys Asp Ala Ile Ile Val Asp Pro Asp Thr 
                1285                1290                1295    
Asn Leu Ser 
            

<210> 11
<211> 1877
<212> PRT
<213> Unknown

<220> 
<223> Organisme inconnu

<400> 11
Met Arg Gln Lys Glu Thr Ile Thr Arg Lys Lys Leu Tyr Lys Ser Gly 
1               5                   10                  15      
Lys Ser Trp Val Ala Ala Ala Thr Ala Phe Ala Val Met Gly Val Ser 
            20                  25                  30          
Ala Val Thr Thr Val Ser Ala Asp Thr Gln Thr Pro Val Gly Thr Thr 
        35                  40                  45              
Gln Ser Gln Gln Asp Leu Thr Gly Gln Arg Gly Gln Asp Lys Pro Thr 
    50                  55                  60                  
Thr Lys Glu Val Ile Asp Lys Lys Glu Pro Val Pro Gln Val Ser Ala 
65                  70                  75                  80  
Gln Asn Ala Gly Asp Leu Ser Ala Asp Ala Lys Thr Thr Lys Ala Asp 
                85                  90                  95      
Asp Lys Gln Asp Thr Gln Pro Thr Asn Ala Gln Leu Pro Asp Gln Gly 
            100                 105                 110         
Asn Lys Gln Thr Asn Ser Asn Ser Asp Lys Gly Val Lys Glu Ser Thr 
        115                 120                 125             
Thr Ala Pro Val Lys Thr Thr Asp Val Pro Ser Lys Ser Val Thr Pro 
    130                 135                 140                 
Glu Thr Asn Thr Ser Ile Asn Gly Gly Gln Tyr Val Glu Lys Asp Gly 
145                 150                 155                 160 
Gln Phe Val Tyr Ile Asp Gln Ser Gly Lys Gln Val Ser Gly Leu Gln 
                165                 170                 175     
Asn Ile Glu Gly His Thr Gln Tyr Phe Asp Pro Lys Thr Gly Tyr Gln 
            180                 185                 190         
Thr Lys Gly Glu Leu Lys Asn Ile Asp Asp Asn Ala Tyr Tyr Phe Asp 
        195                 200                 205             
Lys Asn Ser Gly Asn Gly Arg Thr Phe Thr Lys Ile Ser Asn Gly Ser 
    210                 215                 220                 
Tyr Ser Glu Lys Asp Gly Met Trp Gln Tyr Val Asp Ser His Asp Lys 
225                 230                 235                 240 
Gln Pro Val Lys Gly Leu Tyr Asp Val Glu Gly Asn Leu Gln Tyr Phe 
                245                 250                 255     
Asp Leu Ser Thr Gly Asn Gln Ala Lys His Gln Ile Arg Ser Val Asp 
            260                 265                 270         
Gly Val Thr Tyr Tyr Phe Asp Ala Asp Ser Gly Asn Ala Thr Ala Phe 
        275                 280                 285             
Lys Ala Val Thr Asn Gly Arg Tyr Ala Glu Gln Thr Thr Lys Asp Lys 
    290                 295                 300                 
Asp Gly Asn Glu Thr Ser Tyr Trp Ala Tyr Leu Asp Asn Gln Gly Asn 
305                 310                 315                 320 
Ala Ile Lys Gly Leu Asn Asp Val Asn Gly Glu Ile Gln Tyr Phe Asp 
                325                 330                 335     
Glu His Thr Gly Glu Gln Leu Lys Gly His Thr Ala Thr Leu Asp Gly 
            340                 345                 350         
Thr Thr Tyr Tyr Phe Glu Gly Asn Lys Gly Asn Leu Val Ser Val Val 
        355                 360                 365             
Asn Thr Ala Pro Thr Gly Gln Tyr Lys Ile Asn Gly Asp Asn Val Tyr 
    370                 375                 380                 
Tyr Leu Asp Asn Asn Asn Glu Ala Ile Lys Gly Leu Tyr Gly Ile Asn 
385                 390                 395                 400 
Gly Asn Leu Asn Tyr Phe Asp Leu Ala Thr Gly Ile Gln Leu Lys Gly 
                405                 410                 415     
Gln Ala Lys Asn Ile Asp Gly Ile Gly Tyr Tyr Phe Asp Lys Asp Thr 
            420                 425                 430         
Gly Asn Gly Ser Tyr Gln Tyr Thr Leu Met Ala Pro Ser Asn Lys Asn 
        435                 440                 445             
Asp Tyr Thr Gln His Asn Val Val Asn Asn Leu Ser Glu Ser Asn Phe 
    450                 455                 460                 
Lys Asn Leu Val Asp Gly Phe Leu Thr Ala Glu Thr Trp Tyr Arg Pro 
465                 470                 475                 480 
Ala Gln Ile Leu Ser His Gly Thr Asp Trp Val Ala Ser Thr Asp Lys 
                485                 490                 495     
Asp Phe Arg Pro Leu Ile Thr Val Trp Trp Pro Asn Lys Asp Ile Gln 
            500                 505                 510         
Val Asn Tyr Leu Arg Leu Met Gln Asn Glu Gly Val Leu Asn Gln Ser 
        515                 520                 525             
Ala Val Tyr Asp Leu Asn Thr Asp Gln Leu Leu Leu Asn Glu Ala Ala 
    530                 535                 540                 
Gln Gln Ala Gln Ile Gly Ile Glu Lys Lys Ile Ser Gln Thr Gly Asn 
545                 550                 555                 560 
Thr Asp Trp Leu Asn Asn Val Leu Phe Thr Thr His Asp Gly Gln Pro 
                565                 570                 575     
Ser Phe Ile Lys Gln Gln Tyr Leu Trp Asn Ser Asp Ser Glu Tyr His 
            580                 585                 590         
Thr Gly Pro Phe Gln Gly Gly Tyr Leu Lys Tyr Gln Asn Ser Asp Leu 
        595                 600                 605             
Thr Pro Asn Val Asn Ser Lys Tyr Arg Asn Ala Asp Asn Ser Leu Asp 
    610                 615                 620                 
Phe Leu Leu Ala Asn Asp Val Asp Asn Ser Asn Pro Ile Val Gln Ala 
625                 630                 635                 640 
Glu Asp Leu Asn Trp Leu Tyr Tyr Leu Leu Asn Phe Gly Ser Ile Thr 
                645                 650                 655     
Thr Gln Gly Lys Glu Asn Asn Ser Asn Phe Asp Ser Ile Arg Ile Asp 
            660                 665                 670         
Ala Val Asp Phe Val Ser Asn Asp Leu Ile Gln Arg Thr Tyr Asp Tyr 
        675                 680                 685             
Leu Arg Ala Ala Tyr Gly Val Asp Lys Asn Asp Lys Glu Ala Asn Ala 
    690                 695                 700                 
His Leu Ser Leu Val Glu Ala Gly Leu Asp Ala Gly Thr Thr Thr Ile 
705                 710                 715                 720 
His Gln Asp Ala Leu Ile Glu Ser Asp Ile Arg Glu Ala Met Lys Lys 
                725                 730                 735     
Ser Leu Thr Asn Gly Pro Gly Ser Asn Ile Ser Leu Ser Asn Leu Ile 
            740                 745                 750         
Gln Asp Lys Glu Gly Asp Lys Leu Ile Ala Asp Arg Ala Asn Asn Ser 
        755                 760                 765             
Thr Glu Asn Val Ala Ile Pro Asn Tyr Ser Ile Ile His Ala His Asp 
    770                 775                 780                 
Lys Asp Ile Gln Asp Lys Val Gly Ala Ala Ile Thr Asp Ala Thr Gly 
785                 790                 795                 800 
Ala Asp Trp Thr Asn Phe Thr Pro Glu Gln Leu Gln Lys Gly Leu Ser 
                805                 810                 815     
Leu Tyr Tyr Glu Asp Gln Arg Lys Ile Glu Lys Lys Tyr Asn Gln Tyr 
            820                 825                 830         
Asn Ile Pro Ser Ala Tyr Ala Leu Leu Leu Thr Asn Lys Asp Thr Val 
        835                 840                 845             
Pro Arg Val Tyr Tyr Gly Asp Met Tyr Gln Asp Asp Gly Gln Tyr Met 
    850                 855                 860                 
Gln Lys Gln Ser Leu Tyr Phe Asp Thr Ile Thr Ala Leu Met Glu Ala 
865                 870                 875                 880 
Arg Lys Gln Phe Val Ala Gly Gly Gln Thr Ile Asn Val Asp Asp Asn 
                885                 890                 895     
Gly Val Leu Thr Ser Val Arg Phe Gly Lys Gly Ala Met Thr Ala Asn 
            900                 905                 910         
Asp Ile Gly Thr Asn Glu Thr Arg Thr Gln Gly Ile Gly Val Val Ile 
        915                 920                 925             
Ala Asn Asp Pro Ser Leu Lys Leu Ser Lys Asp Ser Lys Val Thr Leu 
    930                 935                 940                 
His Met Gly Ala Ala His Arg Asn Gln Asn Tyr Arg Ala Leu Leu Leu 
945                 950                 955                 960 
Thr Thr Asp Asn Gly Ile Asp Ser Tyr Ser Ser Ser Lys Asn Ala Pro 
                965                 970                 975     
Val Ile Lys Thr Asp Asp Asn Gly Asp Leu Val Phe Ser Asn Gln Asp 
            980                 985                 990         
Ile Asn Asp Gln Leu Asn Thr Lys Val His Gly Phe Leu Asn Ser Glu 
        995                 1000                1005            
Val Ser Gly Tyr Leu Ser Ala Trp Val Pro Leu Asp Ala Thr Glu Gln 
    1010                1015                1020                
Gln Asp Ala Arg Thr Leu Pro Ser Glu Lys Ser Val Asn Asp Gly Lys 
1025                1030                1035                1040
Val Leu His Ser Asn Ala Ala Leu Asp Ser Asn Leu Ile Tyr Glu Ala 
                1045                1050                1055    
Phe Ser Asn Phe Gln Pro Met Pro Thr Asn Arg Asn Glu Tyr Thr Asn 
            1060                1065                1070        
Val Val Ile Ala Asp Lys Ala Asp Thr Phe Lys Ser Trp Gly Ile Thr 
        1075                1080                1085            
Ser Phe Glu Met Ala Pro Gln Tyr Arg Ser Ser Gln Asp Lys Thr Phe 
    1090                1095                1100                
Leu Asp Ser Thr Ile Asp Asn Gly Tyr Ala Phe Thr Asp Arg Tyr Asp 
1105                1110                1115                1120
Leu Gly Phe Glu Lys Pro Thr Lys Tyr Gly Asn Asp Glu Asp Leu Arg 
                1125                1130                1135    
Gln Ala Ile Lys Gln Leu His Ser Ser Gly Met Gln Val Met Ala Asp 
            1140                1145                1150        
Val Val Ala Asn Gln Ile Tyr Asn Leu Pro Gly Lys Glu Val Ala Ser 
        1155                1160                1165            
Thr Asn Arg Val Asp Trp Asn Gly Asn Asn Leu Ser Thr Pro Phe Gly 
    1170                1175                1180                
Thr Gln Met Tyr Val Val Asn Thr Val Gly Gly Gly Lys Tyr Gln Asn 
1185                1190                1195                1200
Lys Tyr Gly Gly Glu Phe Leu Asp Lys Leu Lys Ala Ala Tyr Pro Asp 
                1205                1210                1215    
Ile Phe Arg Ser Lys Asn Tyr Glu Tyr Asp Val Lys Asn Tyr Gly Gly 
            1220                1225                1230        
Asn Gly Thr Gly Ser Val Tyr Tyr Thr Val Asp Ser Lys Thr Arg Ala 
        1235                1240                1245            
Glu Leu Asp Thr Asp Thr Lys Ile Lys Glu Trp Ser Ala Lys Tyr Met 
    1250                1255                1260                
Asn Gly Thr Asn Val Leu Gly Leu Gly Met Gly Tyr Val Leu Lys Asp 
1265                1270                1275                1280
Trp Gln Thr Gly Gln Tyr Phe Asn Val Ser Asn Gln Asn Met Lys Phe 
                1285                1290                1295    
Leu Leu Pro Ser Asp Leu Ile Ser Asn Asp Ile Thr Val Gln Leu Gly 
            1300                1305                1310        
Val Pro Val Thr Asp Lys Lys Ile Ile Phe Asp Pro Ala Ser Ala Tyr 
        1315                1320                1325            
Asn Met Tyr Ser Asn Leu Pro Glu Asp Met Gln Val Met Asp Tyr Gln 
    1330                1335                1340                
Asp Asp Lys Lys Ser Thr Pro Ser Ile Lys Pro Leu Ser Ser Tyr Asn 
1345                1350                1355                1360
Asn Lys Gln Val Gln Val Thr Arg Gln Tyr Thr Asp Ser Lys Gly Val 
                1365                1370                1375    
Ser Trp Asn Leu Ile Thr Phe Ala Gly Gly Asp Leu Gln Gly Gln Lys 
            1380                1385                1390        
Leu Trp Val Asp Ser Arg Ala Leu Thr Met Thr Pro Phe Lys Thr Met 
        1395                1400                1405            
Asn Gln Ile Ser Phe Ile Ser Tyr Ala Asn Arg Asn Asp Gly Leu Phe 
    1410                1415                1420                
Leu Asn Ala Pro Tyr Gln Val Lys Gly Tyr Gln Leu Ala Gly Met Ser 
1425                1430                1435                1440
Asn Gln Tyr Lys Gly Gln Gln Val Thr Ile Ala Gly Val Ala Asn Val 
                1445                1450                1455    
Ser Gly Lys Asp Trp Ser Leu Ile Ser Phe Asn Gly Thr Gln Tyr Trp 
            1460                1465                1470        
Ile Asp Ser Gln Ala Leu Asn Thr Asn Phe Thr His Asp Met Asn Gln 
        1475                1480                1485            
Lys Val Phe Val Asn Thr Thr Ser Asn Leu Asp Gly Leu Phe Leu Asn 
    1490                1495                1500                
Ala Pro Tyr Arg Gln Pro Gly Tyr Lys Leu Ala Gly Leu Ala Lys Asn 
1505                1510                1515                1520
Tyr Asn Asn Gln Thr Val Thr Val Ser Gln Gln Tyr Phe Asp Asp Gln 
                1525                1530                1535    
Gly Thr Val Trp Ser Gln Val Val Leu Gly Gly Gln Thr Val Trp Val 
            1540                1545                1550        
Asp Asn His Ala Leu Ala Gln Met Gln Val Arg Asp Thr Asn Gln Gln 
        1555                1560                1565            
Leu Tyr Val Asn Ser Asn Gly Arg Asn Asp Gly Leu Phe Leu Asn Ala 
    1570                1575                1580                
Pro Tyr Arg Gly Gln Gly Ser Gln Leu Ile Gly Met Thr Ala Asp Tyr 
1585                1590                1595                1600
Asn Gly Gln His Val Gln Val Thr Lys Gln Gly Gln Asp Ala Tyr Gly 
                1605                1610                1615    
Ala Gln Trp Arg Leu Ile Thr Leu Asn Asn Gln Gln Val Trp Val Asp 
            1620                1625                1630        
Ser Arg Ala Leu Ser Thr Thr Ile Met Gln Ala Met Asn Asp Asp Met 
        1635                1640                1645            
Tyr Val Asn Ser Ser Gln Arg Thr Asp Gly Leu Trp Leu Asn Ala Pro 
    1650                1655                1660                
Tyr Thr Met Ser Gly Ala Lys Trp Ala Gly Asp Thr Arg Ser Ala Asn 
1665                1670                1675                1680
Gly Arg Tyr Val His Ile Ser Lys Ala Tyr Ser Asn Glu Val Gly Asn 
                1685                1690                1695    
Thr Tyr Tyr Leu Thr Asn Leu Asn Gly Gln Ser Thr Trp Ile Asp Lys 
            1700                1705                1710        
Arg Ala Phe Thr Ala Thr Phe Asp Gln Val Val Ala Leu Asn Ala Thr 
        1715                1720                1725            
Ile Val Ala Arg Gln Arg Pro Asp Gly Met Phe Lys Thr Ala Pro Tyr 
    1730                1735                1740                
Gly Glu Ala Gly Ala Gln Phe Val Asp Tyr Val Thr Asn Tyr Asn Gln 
1745                1750                1755                1760
Gln Thr Val Pro Val Thr Lys Gln His Ser Asp Ala Gln Gly Asn Gln 
                1765                1770                1775    
Trp Tyr Leu Ala Thr Val Asn Gly Thr Gln Tyr Trp Ile Asp Gln Arg 
            1780                1785                1790        
Ser Phe Ser Pro Val Val Thr Lys Val Val Asp Tyr Gln Ala Lys Ile 
        1795                1800                1805            
Val Pro Arg Thr Thr Arg Asp Gly Val Phe Ser Gly Ala Pro Tyr Gly 
    1810                1815                1820                
Glu Val Asn Ala Lys Leu Val Asn Met Ala Thr Ala Tyr Gln Asn Gln 
1825                1830                1835                1840
Val Val His Ala Thr Gly Glu Tyr Thr Asn Ala Ser Gly Ile Thr Trp 
                1845                1850                1855    
Ser Gln Phe Ala Leu Ser Gly Gln Glu Asp Lys Leu Trp Ile Asp Lys 
            1860                1865                1870        
Arg Ala Leu Gln Ala 
        1875        

<210> 12
<211> 1125
<212> PRT
<213> Leuconostoc mesenteroides

<220> 
<221> VARIANT
<222> 403
<223> Tel que defini ci-apres

<220> 
<221> VARIANT
<222> 403,404,430,431,434
<223> (i) Xaa en position 403 représentant, indépendamment de Xaa en po
      sition 404, Xaa en position 430, Xaa en position 431 et Xaa en po
      sition 434, un acide aminé choisi dans le groupe constitué de G, 
      S, V, C, F, N, I, L et W ; Xaa en position 404 représentant, indé

<220> 
<221> VARIANT
<222> 404
<223> Tel que defini ci-avant

<220> 
<221> VARIANT
<222> 430
<223> Tel que defini ci-avant

<220> 
<221> VARIANT
<222> 431
<223> Tel que defini ci-avant

<220> 
<221> VARIANT
<222> 434
<223> Tel que defini ci-avant

<400> 12
Met Ala His His His His His His Val Thr Ser Leu Tyr Lys Lys Ala 
1               5                   10                  15      
Gly Ser Ala Ala Ala Pro Phe Thr Met Ala Gln Ala Gly His Tyr Ile 
            20                  25                  30          
Thr Lys Asn Gly Asn Asp Trp Gln Tyr Asp Thr Asn Gly Glu Leu Ala 
        35                  40                  45              
Lys Gly Leu Arg Gln Asp Ser Asn Gly Lys Leu Arg Tyr Phe Asp Leu 
    50                  55                  60                  
Thr Thr Gly Ile Gln Ala Lys Gly Gln Phe Val Thr Ile Gly Gln Glu 
65                  70                  75                  80  
Thr Tyr Tyr Phe Ser Lys Asp His Gly Asp Ala Gln Leu Leu Pro Met 
                85                  90                  95      
Val Thr Glu Gly His Tyr Gly Thr Ile Thr Leu Lys Gln Gly Gln Asp 
            100                 105                 110         
Thr Lys Thr Ala Trp Val Tyr Arg Asp Gln Asn Asn Thr Ile Leu Lys 
        115                 120                 125             
Gly Leu Gln Asn Ile Asn Gly Thr Leu Gln Phe Phe Asp Pro Tyr Thr 
    130                 135                 140                 
Gly Glu Gln Leu Lys Gly Gly Val Ala Lys Tyr Asp Asp Lys Leu Phe 
145                 150                 155                 160 
Tyr Phe Glu Ser Gly Lys Gly Asn Leu Val Ser Thr Val Ala Gly Asp 
                165                 170                 175     
Tyr Gln Asp Gly His Tyr Ile Ser Gln Asp Gly Gln Thr Arg Tyr Ala 
            180                 185                 190         
Asp Lys Gln Asn Gln Leu Val Lys Gly Leu Val Thr Val Asn Gly Ala 
        195                 200                 205             
Leu Gln Tyr Phe Asp Asn Ala Thr Gly Asn Gln Ile Lys Asn Gln Gln 
    210                 215                 220                 
Val Ile Val Asp Gly Lys Thr Tyr Tyr Phe Asp Asp Lys Gly Asn Gly 
225                 230                 235                 240 
Glu Tyr Leu Phe Thr Asn Thr Leu Asp Met Ser Thr Asn Ala Phe Ser 
                245                 250                 255     
Thr Lys Asn Val Ala Phe Asn His Asp Ser Ser Ser Phe Asp His Thr 
            260                 265                 270         
Val Asp Gly Phe Leu Thr Ala Asp Thr Trp Tyr Arg Pro Lys Ser Ile 
        275                 280                 285             
Leu Ala Asn Gly Thr Thr Trp Arg Asp Ser Thr Asp Lys Asp Met Arg 
    290                 295                 300                 
Pro Leu Ile Thr Val Trp Trp Pro Asn Lys Asn Val Gln Val Asn Tyr 
305                 310                 315                 320 
Leu Asn Phe Met Lys Ala Asn Gly Leu Leu Thr Thr Ala Ala Gln Tyr 
                325                 330                 335     
Thr Leu His Ser Asp Gln Tyr Asp Leu Asn Gln Ala Ala Gln Asp Val 
            340                 345                 350         
Gln Val Ala Ile Glu Arg Arg Ile Ala Ser Glu His Gly Thr Asp Trp 
        355                 360                 365             
Leu Gln Lys Leu Leu Phe Glu Ser Gln Asn Asn Asn Pro Ser Phe Val 
    370                 375                 380                 
Lys Gln Gln Phe Ile Trp Asn Lys Asp Ser Glu Tyr His Gly Gly Gly 
385                 390                 395                 400 
Asp Ala Xaa Xaa Gln Gly Gly Tyr Leu Lys Tyr Gly Asn Asn Pro Leu 
                405                 410                 415     
Thr Pro Thr Thr Asn Ser Asp Tyr Arg Gln Pro Gly Asn Xaa Xaa Asp 
            420                 425                 430         
Phe Xaa Leu Ala Asn Asp Val Asp Asn Ser Asn Pro Val Val Gln Ala 
        435                 440                 445             
Glu Asn Leu Asn Trp Leu His Tyr Leu Met Asn Phe Gly Thr Ile Thr 
    450                 455                 460                 
Ala Gly Gln Asp Asp Ala Asn Phe Asp Ser Ile Arg Ile Asp Ala Val 
465                 470                 475                 480 
Asp Phe Ile His Asn Asp Thr Ile Gln Arg Thr Tyr Asp Tyr Leu Arg 
                485                 490                 495     
Asp Ala Tyr Gln Val Gln Gln Ser Glu Ala Lys Ala Asn Gln His Ile 
            500                 505                 510         
Ser Leu Val Glu Ala Gly Leu Asp Ala Gly Thr Ser Thr Ile His Asn 
        515                 520                 525             
Asp Ala Leu Ile Glu Ser Asn Leu Arg Glu Ala Ala Thr Leu Ser Leu 
    530                 535                 540                 
Thr Asn Glu Pro Gly Lys Asn Lys Pro Leu Thr Asn Met Leu Gln Asp 
545                 550                 555                 560 
Val Asp Gly Gly Thr Leu Ile Thr Asp His Thr Gln Asn Ser Thr Glu 
                565                 570                 575     
Asn Gln Ala Thr Pro Asn Tyr Ser Ile Ile His Ala His Asp Lys Gly 
            580                 585                 590         
Val Gln Glu Lys Val Gly Ala Ala Ile Thr Asp Ala Thr Gly Ala Asp 
        595                 600                 605             
Trp Thr Asn Phe Thr Asp Glu Gln Leu Lys Ala Gly Leu Glu Leu Phe 
    610                 615                 620                 
Tyr Lys Asp Gln Arg Ala Thr Asn Lys Lys Tyr Asn Ser Tyr Asn Ile 
625                 630                 635                 640 
Pro Ser Ile Tyr Ala Leu Met Leu Thr Asn Lys Asp Thr Val Pro Arg 
                645                 650                 655     
Met Tyr Tyr Gly Asp Met Tyr Gln Asp Asp Gly Gln Tyr Met Ala Asn 
            660                 665                 670         
Lys Ser Ile Tyr Tyr Asp Ala Leu Val Ser Leu Met Thr Ala Arg Lys 
        675                 680                 685             
Ser Tyr Val Ser Gly Gly Gln Thr Met Ser Val Asp Asn His Gly Leu 
    690                 695                 700                 
Leu Lys Ser Val Arg Phe Gly Lys Asp Ala Met Thr Ala Asn Asp Leu 
705                 710                 715                 720 
Gly Thr Ser Ala Thr Arg Thr Glu Gly Leu Gly Val Ile Ile Gly Asn 
                725                 730                 735     
Asp Pro Lys Leu Gln Leu Asn Asp Ser Asp Lys Val Thr Leu Asp Met 
            740                 745                 750         
Gly Ala Ala His Lys Asn Gln Lys Tyr Arg Ala Val Ile Leu Thr Thr 
        755                 760                 765             
Arg Asp Gly Leu Ala Thr Phe Asn Ser Asp Gln Ala Pro Thr Ala Trp 
    770                 775                 780                 
Thr Asn Asp Gln Gly Thr Leu Thr Phe Ser Asn Gln Glu Ile Asn Gly 
785                 790                 795                 800 
Gln Asp Asn Thr Gln Ile Arg Gly Val Ala Asn Pro Gln Val Ser Gly 
                805                 810                 815     
Tyr Leu Ala Val Trp Val Pro Val Gly Ala Ser Asp Asn Gln Asp Ala 
            820                 825                 830         
Arg Thr Ala Ala Thr Thr Thr Glu Asn His Asp Gly Lys Val Leu His 
        835                 840                 845             
Ser Asn Ala Ala Leu Asp Ser Asn Leu Ile Tyr Glu Gly Phe Ser Asn 
    850                 855                 860                 
Phe Gln Pro Lys Ala Thr Thr His Asp Glu Leu Thr Asn Val Val Ile 
865                 870                 875                 880 
Ala Lys Asn Ala Asp Val Phe Asn Asn Trp Gly Ile Thr Ser Phe Glu 
                885                 890                 895     
Met Ala Pro Gln Tyr Arg Ser Ser Gly Asp His Thr Phe Leu Asp Ser 
            900                 905                 910         
Thr Ile Asp Asn Gly Tyr Ala Phe Thr Asp Arg Tyr Asp Leu Gly Phe 
        915                 920                 925             
Asn Thr Pro Thr Lys Tyr Gly Thr Asp Gly Asp Leu Arg Ala Thr Ile 
    930                 935                 940                 
Gln Ala Leu His His Ala Asn Met Gln Val Met Ala Asp Val Val Asp 
945                 950                 955                 960 
Asn Gln Val Tyr Asn Leu Pro Gly Lys Glu Val Val Ser Ala Thr Arg 
                965                 970                 975     
Ala Gly Val Tyr Gly Asn Asp Asp Ala Thr Gly Phe Gly Thr Gln Leu 
            980                 985                 990         
Tyr Val Thr Asn Ser Val Gly Gly Gly Gln Tyr Gln Glu Lys Tyr Ala 
        995                 1000                1005            
Gly Gln Tyr Leu Glu Ala Leu Lys Ala Lys Tyr Pro Asp Leu Phe Glu 
    1010                1015                1020                
Gly Lys Ala Tyr Asp Tyr Trp Tyr Lys Asn Tyr Ala Asn Asp Gly Ser 
1025                1030                1035                1040
Asn Pro Tyr Tyr Thr Leu Ser His Gly Asp Arg Glu Ser Ile Pro Ala 
                1045                1050                1055    
Asp Val Ala Ile Lys Gln Trp Ser Ala Lys Tyr Met Asn Gly Thr Asn 
            1060                1065                1070        
Val Leu Gly Asn Gly Met Gly Tyr Val Leu Lys Asp Trp His Asn Gly 
        1075                1080                1085            
Gln Tyr Phe Lys Leu Asp Gly Asp Lys Ser Thr Leu Pro Lys Gly Gly 
    1090                1095                1100                
Arg Ala Asp Pro Ala Phe Leu Tyr Lys Val Val Ser Ala Trp Ser His 
1105                1110                1115                1120
Pro Gln Phe Glu Lys 
                1125

<210> 13
<211> 1125
<212> PRT
<213> Leuconostoc mesenteroides

<400> 13
Met Ala His His His His His His Val Thr Ser Leu Tyr Lys Lys Ala 
1               5                   10                  15      
Gly Ser Ala Ala Ala Pro Phe Thr Met Ala Gln Ala Gly His Tyr Ile 
            20                  25                  30          
Thr Lys Asn Gly Asn Asp Trp Gln Tyr Asp Thr Asn Gly Glu Leu Ala 
        35                  40                  45              
Lys Gly Leu Arg Gln Asp Ser Asn Gly Lys Leu Arg Tyr Phe Asp Leu 
    50                  55                  60                  
Thr Thr Gly Ile Gln Ala Lys Gly Gln Phe Val Thr Ile Gly Gln Glu 
65                  70                  75                  80  
Thr Tyr Tyr Phe Ser Lys Asp His Gly Asp Ala Gln Leu Leu Pro Met 
                85                  90                  95      
Val Thr Glu Gly His Tyr Gly Thr Ile Thr Leu Lys Gln Gly Gln Asp 
            100                 105                 110         
Thr Lys Thr Ala Trp Val Tyr Arg Asp Gln Asn Asn Thr Ile Leu Lys 
        115                 120                 125             
Gly Leu Gln Asn Ile Asn Gly Thr Leu Gln Phe Phe Asp Pro Tyr Thr 
    130                 135                 140                 
Gly Glu Gln Leu Lys Gly Gly Val Ala Lys Tyr Asp Asp Lys Leu Phe 
145                 150                 155                 160 
Tyr Phe Glu Ser Gly Lys Gly Asn Leu Val Ser Thr Val Ala Gly Asp 
                165                 170                 175     
Tyr Gln Asp Gly His Tyr Ile Ser Gln Asp Gly Gln Thr Arg Tyr Ala 
            180                 185                 190         
Asp Lys Gln Asn Gln Leu Val Lys Gly Leu Val Thr Val Asn Gly Ala 
        195                 200                 205             
Leu Gln Tyr Phe Asp Asn Ala Thr Gly Asn Gln Ile Lys Asn Gln Gln 
    210                 215                 220                 
Val Ile Val Asp Gly Lys Thr Tyr Tyr Phe Asp Asp Lys Gly Asn Gly 
225                 230                 235                 240 
Glu Tyr Leu Phe Thr Asn Thr Leu Asp Met Ser Thr Asn Ala Phe Ser 
                245                 250                 255     
Thr Lys Asn Val Ala Phe Asn His Asp Ser Ser Ser Phe Asp His Thr 
            260                 265                 270         
Val Asp Gly Phe Leu Thr Ala Asp Thr Trp Tyr Arg Pro Lys Ser Ile 
        275                 280                 285             
Leu Ala Asn Gly Thr Thr Trp Arg Asp Ser Thr Asp Lys Asp Met Arg 
    290                 295                 300                 
Pro Leu Ile Thr Val Trp Trp Pro Asn Lys Asn Val Gln Val Asn Tyr 
305                 310                 315                 320 
Leu Asn Phe Met Lys Ala Asn Gly Leu Leu Thr Thr Ala Ala Gln Tyr 
                325                 330                 335     
Thr Leu His Ser Asp Gln Tyr Asp Leu Asn Gln Ala Ala Gln Asp Val 
            340                 345                 350         
Gln Val Ala Ile Glu Arg Arg Ile Ala Ser Glu His Gly Thr Asp Trp 
        355                 360                 365             
Leu Gln Lys Leu Leu Phe Glu Ser Gln Asn Asn Asn Pro Ser Phe Val 
    370                 375                 380                 
Lys Gln Gln Phe Ile Trp Asn Lys Asp Ser Glu Tyr His Gly Gly Gly 
385                 390                 395                 400 
Asp Ala Trp Phe Gln Gly Gly Tyr Leu Lys Tyr Gly Asn Asn Pro Leu 
                405                 410                 415     
Thr Pro Thr Thr Asn Ser Asp Tyr Arg Gln Pro Gly Asn Ala Ile Glu 
            420                 425                 430         
Phe Ile Leu Ala Asn Asp Val Asp Asn Ser Asn Pro Val Val Gln Ala 
        435                 440                 445             
Glu Asn Leu Asn Trp Leu His Tyr Leu Met Asn Phe Gly Thr Ile Thr 
    450                 455                 460                 
Ala Gly Gln Asp Asp Ala Asn Phe Asp Ser Ile Arg Ile Asp Ala Val 
465                 470                 475                 480 
Asp Phe Ile His Asn Asp Thr Ile Gln Arg Thr Tyr Asp Tyr Leu Arg 
                485                 490                 495     
Asp Ala Tyr Gln Val Gln Gln Ser Glu Ala Lys Ala Asn Gln His Ile 
            500                 505                 510         
Ser Leu Val Glu Ala Gly Leu Asp Ala Gly Thr Ser Thr Ile His Asn 
        515                 520                 525             
Asp Ala Leu Ile Glu Ser Asn Leu Arg Glu Ala Ala Thr Leu Ser Leu 
    530                 535                 540                 
Thr Asn Glu Pro Gly Lys Asn Lys Pro Leu Thr Asn Met Leu Gln Asp 
545                 550                 555                 560 
Val Asp Gly Gly Thr Leu Ile Thr Asp His Thr Gln Asn Ser Thr Glu 
                565                 570                 575     
Asn Gln Ala Thr Pro Asn Tyr Ser Ile Ile His Ala His Asp Lys Gly 
            580                 585                 590         
Val Gln Glu Lys Val Gly Ala Ala Ile Thr Asp Ala Thr Gly Ala Asp 
        595                 600                 605             
Trp Thr Asn Phe Thr Asp Glu Gln Leu Lys Ala Gly Leu Glu Leu Phe 
    610                 615                 620                 
Tyr Lys Asp Gln Arg Ala Thr Asn Lys Lys Tyr Asn Ser Tyr Asn Ile 
625                 630                 635                 640 
Pro Ser Ile Tyr Ala Leu Met Leu Thr Asn Lys Asp Thr Val Pro Arg 
                645                 650                 655     
Met Tyr Tyr Gly Asp Met Tyr Gln Asp Asp Gly Gln Tyr Met Ala Asn 
            660                 665                 670         
Lys Ser Ile Tyr Tyr Asp Ala Leu Val Ser Leu Met Thr Ala Arg Lys 
        675                 680                 685             
Ser Tyr Val Ser Gly Gly Gln Thr Met Ser Val Asp Asn His Gly Leu 
    690                 695                 700                 
Leu Lys Ser Val Arg Phe Gly Lys Asp Ala Met Thr Ala Asn Asp Leu 
705                 710                 715                 720 
Gly Thr Ser Ala Thr Arg Thr Glu Gly Leu Gly Val Ile Ile Gly Asn 
                725                 730                 735     
Asp Pro Lys Leu Gln Leu Asn Asp Ser Asp Lys Val Thr Leu Asp Met 
            740                 745                 750         
Gly Ala Ala His Lys Asn Gln Lys Tyr Arg Ala Val Ile Leu Thr Thr 
        755                 760                 765             
Arg Asp Gly Leu Ala Thr Phe Asn Ser Asp Gln Ala Pro Thr Ala Trp 
    770                 775                 780                 
Thr Asn Asp Gln Gly Thr Leu Thr Phe Ser Asn Gln Glu Ile Asn Gly 
785                 790                 795                 800 
Gln Asp Asn Thr Gln Ile Arg Gly Val Ala Asn Pro Gln Val Ser Gly 
                805                 810                 815     
Tyr Leu Ala Val Trp Val Pro Val Gly Ala Ser Asp Asn Gln Asp Ala 
            820                 825                 830         
Arg Thr Ala Ala Thr Thr Thr Glu Asn His Asp Gly Lys Val Leu His 
        835                 840                 845             
Ser Asn Ala Ala Leu Asp Ser Asn Leu Ile Tyr Glu Gly Phe Ser Asn 
    850                 855                 860                 
Phe Gln Pro Lys Ala Thr Thr His Asp Glu Leu Thr Asn Val Val Ile 
865                 870                 875                 880 
Ala Lys Asn Ala Asp Val Phe Asn Asn Trp Gly Ile Thr Ser Phe Glu 
                885                 890                 895     
Met Ala Pro Gln Tyr Arg Ser Ser Gly Asp His Thr Phe Leu Asp Ser 
            900                 905                 910         
Thr Ile Asp Asn Gly Tyr Ala Phe Thr Asp Arg Tyr Asp Leu Gly Phe 
        915                 920                 925             
Asn Thr Pro Thr Lys Tyr Gly Thr Asp Gly Asp Leu Arg Ala Thr Ile 
    930                 935                 940                 
Gln Ala Leu His His Ala Asn Met Gln Val Met Ala Asp Val Val Asp 
945                 950                 955                 960 
Asn Gln Val Tyr Asn Leu Pro Gly Lys Glu Val Val Ser Ala Thr Arg 
                965                 970                 975     
Ala Gly Val Tyr Gly Asn Asp Asp Ala Thr Gly Phe Gly Thr Gln Leu 
            980                 985                 990         
Tyr Val Thr Asn Ser Val Gly Gly Gly Gln Tyr Gln Glu Lys Tyr Ala 
        995                 1000                1005            
Gly Gln Tyr Leu Glu Ala Leu Lys Ala Lys Tyr Pro Asp Leu Phe Glu 
    1010                1015                1020                
Gly Lys Ala Tyr Asp Tyr Trp Tyr Lys Asn Tyr Ala Asn Asp Gly Ser 
1025                1030                1035                1040
Asn Pro Tyr Tyr Thr Leu Ser His Gly Asp Arg Glu Ser Ile Pro Ala 
                1045                1050                1055    
Asp Val Ala Ile Lys Gln Trp Ser Ala Lys Tyr Met Asn Gly Thr Asn 
            1060                1065                1070        
Val Leu Gly Asn Gly Met Gly Tyr Val Leu Lys Asp Trp His Asn Gly 
        1075                1080                1085            
Gln Tyr Phe Lys Leu Asp Gly Asp Lys Ser Thr Leu Pro Lys Gly Gly 
    1090                1095                1100                
Arg Ala Asp Pro Ala Phe Leu Tyr Lys Val Val Ser Ala Trp Ser His 
1105                1110                1115                1120
Pro Gln Phe Glu Lys 
                1125

