SEQUENCE LISTING

<110>   Yale University
        GlaxoSmithKline Biologicals SA

<120>   USES OF PARASITE MACROPHAGE MIGRATION INHIBITORY FACTORS

<130>   P063647WO

<140>   PCT/EP2015/______
<141>   2015-03-24

<150>   EP-14161614.4
<151>   2014-03-24

<160>   18

<170>   SeqWin2010, version 1.0

<210>   1
<211>   115
<212>   PRT
<213>   Plasmodium falciparum

<400>   1
Pro Cys Cys Glu Val Ile Thr Asn Val Asn Leu Pro Asp Asp Asn Val 
1               5                   10                  15      

Gln Ser Thr Leu Ser Gln Ile Glu Asn Ala Ile Ser Asp Val Met Gly 
            20                  25                  30          

Lys Pro Leu Gly Tyr Ile Met Ser Asn Tyr Asp Tyr Gln Lys Asn Leu 
        35                  40                  45              

Arg Phe Gly Gly Ser Asn Glu Ala Tyr Cys Phe Val Arg Ile Thr Ser 
    50                  55                  60                  

Ile Gly Gly Ile Asn Arg Ser Asn Asn Ser Ala Leu Ala Asp Gln Ile 
65                  70                  75                  80  

Thr Lys Leu Leu Val Ser Asn Leu Asn Val Lys Ser Arg Arg Ile Tyr 
                85                  90                  95      

Val Glu Phe Arg Asp Cys Ser Ala Gln Asn Phe Ala Phe Ser Gly Ser 
            100                 105                 110         

Leu Phe Gly 
        115 

<210>   2
<211>   115
<212>   PRT
<213>   Plasmodium berghei

<400>   2
Pro Cys Cys Glu Leu Ile Thr Asn Ile Ser Ile Pro Asp Asp Lys Ala 
1               5                   10                  15      

Gln Asn Thr Leu Ser Glu Ile Glu Asp Ala Ile Ser Asn Ile Leu Gly 
            20                  25                  30          

Lys Pro Val Ala Tyr Ile Met Ser Asn Tyr Asp Tyr Gln Lys Asn Leu 
        35                  40                  45              

Arg Phe Ser Gly Ser Asn Glu Gly Tyr Cys Phe Val Arg Leu Thr Ser 
    50                  55                  60                  

Ile Gly Gly Ile Asn Arg Ser Asn Asn Ser Leu Leu Ala Asp Lys Ile 
65                  70                  75                  80  

Thr Lys Ile Leu Ser Asn His Leu Ser Val Lys Pro Arg Arg Val Tyr 
                85                  90                  95      

Ile Glu Phe Arg Asp Cys Ser Ala Gln Asn Phe Ala Phe Ser Gly Ser 
            100                 105                 110         

Leu Phe Gly 
        115 

<210>   3
<211>   115
<212>   PRT
<213>   Plasmodium yoelii

<400>   3
Pro Cys Cys Glu Leu Ile Thr Asn Ile Ser Ile Pro Asp Asp Lys Ala 
1               5                   10                  15      

Gln Asn Ala Leu Ser Glu Ile Glu Asp Ala Ile Ser Asn Val Leu Gly 
            20                  25                  30          

Lys Pro Val Ala Tyr Ile Met Ser Asn Tyr Asp Tyr Gln Lys Asn Leu 
        35                  40                  45              

Arg Phe Ser Gly Ser Asn Glu Gly Tyr Cys Phe Val Arg Leu Thr Ser 
    50                  55                  60                  

Ile Gly Gly Ile Asn Arg Ser Asn Asn Ser Ser Leu Ala Asp Lys Ile 
65                  70                  75                  80  

Thr Lys Ile Leu Ser Asn His Leu Gly Val Lys Pro Arg Arg Val Tyr 
                85                  90                  95      

Ile Glu Phe Arg Asp Cys Ser Ala Gln Asn Phe Ala Phe Ser Gly Ser 
            100                 105                 110         

Leu Phe Gly 
        115 

<210>   4
<211>   115
<212>   PRT
<213>   Plasmodium chabaudi

<400>   4
Pro Cys Cys Glu Leu Ile Thr Asn Ile Ser Ile Pro Asp Asp Lys Ala 
1               5                   10                  15      

Gln Ala Ala Leu Ser Glu Ile Glu Asp Ala Ile Ser Asn Val Leu Gly 
            20                  25                  30          

Lys Pro Thr Ala Tyr Ile Met Ser Asn Tyr Asp Tyr Gln Lys Asn Leu 
        35                  40                  45              

Arg Phe Ala Gly Ser Asn Glu Gly Tyr Cys Phe Val Arg Leu Thr Ser 
    50                  55                  60                  

Leu Gly Gly Ile Asn Arg Ser Asn Asn Ser Ser Leu Ala Asp Lys Ile 
65                  70                  75                  80  

Thr Lys His Leu Ala Asn His Leu Gly Val Lys Pro Arg Arg Val Tyr 
                85                  90                  95      

Ile Glu Phe Arg Asp Cys Ser Ala Gln Asn Phe Ala Phe Ser Gly Ser 
            100                 105                 110         

Leu Phe Gly 
        115 

<210>   5
<211>   115
<212>   PRT
<213>   Plasmodium vivax

<400>   5
Pro Cys Cys Gln Val Ser Thr Asn Ile Asn Ala Ser Asp Asp Asp Ala 
1               5                   10                  15      

Lys Lys Ala Leu Ser Gln Ile Glu Asn Ala Ile Ser Gln Val Leu Gly 
            20                  25                  30          

Lys Pro Leu Gly Tyr Ile Met Ser Asn Leu Asp Tyr Gln Lys His Met 
        35                  40                  45              

Arg Phe Gly Gly Ser His Asp Gly Phe Cys Phe Val Arg Val Thr Ser 
    50                  55                  60                  

Leu Gly Gly Ile Asn Lys Ser Asn Asn Ser Ser Leu Ala Asp Lys Ile 
65                  70                  75                  80  

Thr Lys Ile Leu Ala Ser Thr Leu Asn Val Lys Ser Glu Arg Val Phe 
                85                  90                  95      

Ile Glu Phe Lys Asp Cys Ser Ala Gln Asn Phe Ala Phe Asn Gly Ser 
            100                 105                 110         

Leu Phe Gly 
        115 

<210>   6
<211>   115
<212>   PRT
<213>   Plasmodium knowlesi

<400>   6
Pro Cys Cys Gln Val Ser Thr Asn Ile Asn Val Ser Asp Asp Asp Ala 
1               5                   10                  15      

Lys Lys Ala Leu Met Gln Ile Glu Asn Ala Ile Ser Gln Val Met Asn 
            20                  25                  30          

Lys Pro Met Gly Tyr Ile Met Ser Asn Leu Asp Tyr Gln Lys His Met 
        35                  40                  45              

Arg Phe Gly Gly Ser His Asp Gly Phe Cys Phe Val Arg Val Thr Ser 
    50                  55                  60                  

Ile Ser Gly Ile Ser Arg Ser Asn Asn Thr Ala Leu Ala Asp Lys Ile 
65                  70                  75                  80  

Thr Lys Ile Leu Ala Ser Thr Ile Lys Val Lys Ser Asp Arg Val Phe 
                85                  90                  95      

Ile Glu Phe Lys Asp Cys Ser Ala Gln Asn Phe Ala Phe Asn Gly Ser 
            100                 105                 110         

Leu Phe Gly 
        115 

<210>   7
<211>   115
<212>   PRT
<213>   Toxoplasma gondii

<400>   7
Pro Lys Cys Met Ile Phe Cys Pro Val Ala Ala Thr Pro Ala Gln Gln 
1               5                   10                  15      

Asp Ala Leu Leu Lys Asp Ala Glu Lys Ala Val Ala Asp Ala Leu Gly 
            20                  25                  30          

Lys Pro Leu Ser Tyr Val Met Val Gly Tyr Ser Gln Thr Gly Gln Met 
        35                  40                  45              

Arg Phe Gly Gly Ser Ser Asp Pro Cys Ala Phe Ile Arg Val Ala Ser 
    50                  55                  60                  

Ile Gly Gly Ile Thr Ser Ser Thr Asn Cys Lys Ile Ala Ala Ala Leu 
65                  70                  75                  80  

Ser Ala Ala Cys Glu Arg His Leu Gly Val Pro Lys Asn Arg Ile Tyr 
                85                  90                  95      

Thr Thr Phe Thr Asn Lys Ser Pro Ser Glu Trp Ala Met Gly Asp Arg 
            100                 105                 110         

Thr Phe Gly 
        115 

<210>   8
<211>   112
<212>   PRT
<213>   Leishmania major

<400>   8
Pro Val Ile Gln Thr Phe Val Ser Thr Pro Leu Asp His His Lys Arg 
1               5                   10                  15      

Glu Asn Leu Ala Gln Val Tyr Arg Ala Val Thr Arg Asp Val Leu Gly 
            20                  25                  30          

Lys Pro Glu Asp Leu Val Met Met Thr Phe His Asp Ser Thr Pro Met 
        35                  40                  45              

His Phe Phe Gly Ser Thr Asp Pro Val Ala Cys Val Arg Val Glu Ala 
    50                  55                  60                  

Leu Gly Gly Tyr Gly Pro Ser Glu Pro Glu Lys Val Thr Ser Ile Val 
65                  70                  75                  80  

Thr Ala Ala Ile Thr Lys Glu Cys Gly Ile Val Ala Asp Arg Ile Phe 
                85                  90                  95      

Val Leu Tyr Phe Ser Pro Leu His Cys Gly Trp Asn Gly Thr Asn Phe 
            100                 105                 110         

<210>   9
<211>   112
<212>   PRT
<213>   Leishmania major

<400>   9
Pro Phe Leu Gln Thr Ile Val Ser Val Ser Leu Asp Asp Gln Lys Arg 
1               5                   10                  15      

Ala Asn Leu Ser Ala Ala Tyr Gly Met Ile Cys Arg Glu Glu Leu Gly 
            20                  25                  30          

Lys Pro Glu Asp Phe Val Met Thr Ala Phe Ser Asp Lys Thr Pro Ile 
        35                  40                  45              

Ser Phe Gln Gly Ser Thr Ala Pro Ala Ala Tyr Val Arg Val Glu Ser 
    50                  55                  60                  

Trp Gly Glu Tyr Ala Pro Ser Lys Pro Lys Met Met Thr Pro Arg Ile 
65                  70                  75                  80  

Ala Ala Ala Ile Thr Lys Glu Cys Gly Ile Pro Ala Glu Arg Ile Tyr 
                85                  90                  95      

Val Phe Tyr Tyr Ser Thr Lys His Cys Gly Trp Asn Gly Thr Asn Phe 
            100                 105                 110         

<210>   10
<211>   113
<212>   PRT
<213>   Giardia intestinalis

<400>   10
Pro Cys Ala Ile Val Thr Thr Asn Ala Asp Phe Thr Lys Asp Gln Ala 
1               5                   10                  15      

Asp Ala Phe Cys Leu Asp Met Gly Gln Val Leu Ala Lys Glu Thr Gly 
            20                  25                  30          

Lys Pro Val Ser Tyr Cys Met Ala Gly Val Arg Lys Ala Asp Met Ser 
        35                  40                  45              

Phe Gly Thr Ser Thr Asp Leu Cys Cys Phe Val Asp Phe Tyr Cys Ile 
    50                  55                  60                  

Gly Val Ile Ser Gln Ala Lys Asn Pro Ser Ile Ser Ala Ala Ile Thr 
65                  70                  75                  80  

Gly Cys Leu Thr Gln His Phe Lys Val Lys Pro Glu Arg Val Tyr Ile 
                85                  90                  95      

Ser Phe Asn Glu Ala Lys Gly His Asn Trp Gly Phe Asn Gly Ser Thr 
            100                 105                 110         

Phe 
    

<210>   11
<211>   114
<212>   PRT
<213>   Brugia malayi

<400>   11
Pro Tyr Phe Thr Ile Asp Thr Asn Ile Pro Gln Asn Ser Ile Ser Ser 
1               5                   10                  15      

Ala Phe Leu Lys Lys Ala Ser Asn Val Val Ala Lys Ala Leu Gly Lys 
            20                  25                  30          

Pro Glu Ser Tyr Val Ser Ile His Val Asn Gly Gly Gln Ala Met Val 
        35                  40                  45              

Phe Gly Gly Ser Glu Asp Pro Cys Ala Val Cys Val Leu Lys Ser Ile 
    50                  55                  60                  

Gly Cys Val Gly Pro Lys Val Asn Asn Ser His Ala Glu Lys Leu Tyr 
65                  70                  75                  80  

Lys Leu Leu Ala Asp Glu Leu Lys Ile Pro Lys Asn Arg Cys Tyr Ile 
                85                  90                  95      

Glu Phe Val Asp Ile Glu Ala Ser Ser Met Ala Phe Asn Gly Ser Thr 
            100                 105                 110         

Phe Gly 
        

<210>   12
<211>   114
<212>   PRT
<213>   Wuchereria bancrofti

<400>   12
Pro Tyr Phe Thr Ile Asp Thr Asn Lys Pro Gln Asp Ser Ile Ser Ser 
1               5                   10                  15      

Ala Phe Leu Lys Lys Ala Pro Asn Val Val Pro Lys Ala Leu Gly Lys 
            20                  25                  30          

Pro Glu Ser Tyr Val Ser Ile His Val Asn Gly Gly Gln Pro Met Val 
        35                  40                  45              

Phe Gly Gly Ser Glu Asp Pro Cys Pro Val Cys Val Leu Lys Ser Ile 
    50                  55                  60                  

Gly Cys Val Gly Pro Lys Val Asn Asn Ser His Ala Glu Lys Leu Tyr 
65                  70                  75                  80  

Lys Leu Leu Ala Asp Glu Leu Lys Ile Pro Lys Asn Arg Cys Tyr Ile 
                85                  90                  95      

Glu Ser Val Asp Ile Glu Ala Ser Ser Met Ala Phe Asn Gly Ser Thr 
            100                 105                 110         

Phe Gly 
        

<210>   13
<211>   118
<212>   PRT
<213>   Ancylostoma duodenale

<400>   13
Pro Met Val Arg Val Ala Thr Asn Leu Pro Asp Lys Asp Val Pro Ala 
1               5                   10                  15      

Asn Phe Glu Glu Arg Leu Thr Asp Ile Leu Ala Glu Ser Met Asn Lys 
            20                  25                  30          

Pro Arg Asn Arg Ile Ala Ile Glu Val Met Ala Gly Gln Arg Ile Thr 
        35                  40                  45              

His Gly Ala Ser Arg Asn Pro Val Ala Val Ile Lys Val Glu Ser Ile 
    50                  55                  60                  

Gly Ala Leu Ser Ala Asp Asp Asn Ile Arg His Thr Gln Lys Ile Thr 
65                  70                  75                  80  

Gln Phe Cys Gln Asp Thr Leu Lys Leu Pro Lys Asp Lys Val Ile Ile 
                85                  90                  95      

Thr Tyr Phe Asp Leu Gln Pro Ile His Val Gly Phe Asn Gly Thr Thr 
            100                 105                 110         

Val Ala Ala Ala Thr Met 
        115             

<210>   14
<211>   118
<212>   PRT
<213>   Ancylostoma ceylanicum

<400>   14
Pro Met Val Arg Val Ala Thr Asn Leu Pro Asp Lys Asp Val Pro Ala 
1               5                   10                  15      

Asn Phe Glu Glu Arg Leu Thr Asp Leu Leu Ala Glu Ser Met Asn Lys 
            20                  25                  30          

Pro Arg Asn Arg Ile Ala Ile Glu Val Leu Ala Gly Gln Arg Ile Thr 
        35                  40                  45              

His Gly Ala Ser Arg Asn Pro Val Ala Val Ile Lys Val Glu Ser Ile 
    50                  55                  60                  

Gly Ala Leu Ser Ala Asp Asp Asn Ile Arg His Thr Gln Lys Ile Thr 
65                  70                  75                  80  

Gln Phe Cys Gln Asp Thr Leu Lys Leu Pro Lys Asp Lys Val Ile Ile 
                85                  90                  95      

Thr Tyr Phe Asp Leu Gln Pro Ile His Val Gly Phe Asn Gly Thr Thr 
            100                 105                 110         

Val Ala Ala Ala Thr Met 
        115             

<210>   15
<211>   114
<212>   PRT
<213>   Ancylostoma ceylanicum

<400>   15
Pro Val Phe Gln Leu His Thr Asn Val Ser Gln Asp Lys Val Thr Pro 
1               5                   10                  15      

Asp Leu Leu Lys Gln Ile Ser Ala Leu Val Ala Arg Ile Leu His Lys 
            20                  25                  30          

Pro Glu Ser Tyr Val Ala Val His Val Val Pro Asp Gln Lys Met Thr 
        35                  40                  45              

Phe Ala Gly Thr Asp Gly Pro Cys Gly Ile Gly Ile Leu Lys Ser Ile 
    50                  55                  60                  

Gly Gly Val Gly Gly Ser Gln Asn Asn Ser His Ala Lys Ala Leu Phe 
65                  70                  75                  80  

Ala Leu Ile Lys Asp His Leu Gly Ile Glu Gly Ser Arg Met Tyr Ile 
                85                  90                  95      

Glu Phe Val Asp Ile Gly Ala Ser Asp Ile Ala His Asn Gly Arg Thr 
            100                 105                 110         

Phe Ala 
        

<210>   16
<211>   113
<212>   PRT
<213>   Trichinella spiralis

<400>   16
Pro Ile Phe Thr Leu Asn Thr Asn Ile Lys Ala Thr Asp Val Pro Ser 
1               5                   10                  15      

Asp Phe Leu Ser Ser Thr Ser Ala Leu Val Gly Asn Ile Leu Ser Lys 
            20                  25                  30          

Pro Gly Ser Tyr Val Ala Val His Ile Asn Thr Asp Gln Gln Leu Ser 
        35                  40                  45              

Phe Gly Gly Ser Thr Asn Pro Ala Ala Phe Gly Thr Leu Met Ser Ile 
    50                  55                  60                  

Gly Gly Ile Glu Pro Ser Arg Asn Arg Asp His Ser Ala Lys Leu Phe 
65                  70                  75                  80  

Asp His Leu Asn Lys Lys Leu Gly Ile Pro Lys Asn Arg Met Tyr Ile 
                85                  90                  95      

His Phe Val Asn Leu Asn Gly Asp Asp Val Gly Trp Asn Gly Thr Thr 
            100                 105                 110         

Phe 
    

<210>   17
<211>   113
<212>   PRT
<213>   Trichuris trichiura

<400>   17
Pro Ile Phe Thr Phe Ser Thr Asn Val Pro Ser Glu Asn Ile Ser Val 
1               5                   10                  15      

Asp Phe Leu Lys Ser Thr Ser Lys Leu Ile Ala Gly Met Leu Gly Lys 
            20                  25                  30          

Pro Glu Ser Tyr Val Ala Val His Ile Asn Gly Gly Gln Lys Ile Thr 
        35                  40                  45              

Phe Gly Gly Thr Asp Ala Pro Ala Gly Phe Gly Gln Leu Leu Ser Leu 
    50                  55                  60                  

Gly Gly Val Gly Gly Glu Lys Asn Arg Ser His Ser Ala Lys Leu Phe 
65                  70                  75                  80  

Lys His Leu Thr Asp Gly Leu Gly Ile Pro Gly Asn Arg Met Tyr Ile 
                85                  90                  95      

Asn Phe Val Asp Met Arg Gly Ser Asp Val Gly Tyr Asn Gly Ser Thr 
            100                 105                 110         

Phe 
    

<210>   18
<211>   114
<212>   PRT
<213>   Onchocerca volvulus

<400>   18
Pro Ala Phe Thr Ile Asn Thr Asn Ile Pro Gln Ser Asn Val Ser Asp 
1               5                   10                  15      

Ala Phe Leu Lys Lys Ala Ser Ser Thr Val Ala Lys Ala Leu Gly Lys 
            20                  25                  30          

Pro Glu Ser Tyr Val Ala Ile His Val Asn Gly Gly Gln Ala Met Val 
        35                  40                  45              

Phe Gly Gly Ser Thr Asp Pro Cys Ala Val Cys Val Leu Lys Ser Ile 
    50                  55                  60                  

Gly Cys Val Gly Pro Asn Val Asn Asn Ser His Ser Glu Lys Leu Phe 
65                  70                  75                  80  

Lys Leu Leu Ala Asp Glu Leu Lys Ile Pro Lys Asn Arg Cys Tyr Ile 
                85                  90                  95      

Glu Phe Val Asn Ile Asp Ala Ser Thr Met Ala Phe Asn Gly Ser Thr 
            100                 105                 110         

Phe Gly 
        

