                         LISTADO DE SECUENCIAS

<110>  SERVICIO ANDALUZ DE SALUD
 
<120>  MTODO DE PREDICCIN DE RESPUESTA AL TRATAMIENTO DE LA LEUCEMIA LINFOBLSTICA AGUDA

<130>  P-06817

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  8769
<212>  DNA
<213>  Homo sapiens

<400>  1
atttagaggc ggcgccaggg cggccgcgga gaaacgtgac acaccagccc tctcggaggg       60

gtttcggacc gaagggaaga agctgcgccg tgtcgtccgt ctccctgcgc gccgcgggca      120

cttctcctgg gctctccccg aactctcccg cgacctctgc gcgccctcag gccgccttcc      180

ccgccctggg ctcgggacaa cttctggggt ggggtgcaaa gaaagtttgc ggctcctgcc      240

gccggcctct ccgcctcttg gcctaggagg ctcgccgccc gcgcccgctc gttcggcctt      300

gcccgggacc gcgtcctgcc ccgagaccgc caccatgaac aagctttaca tcggcaacct      360

caacgagagc gtgacccccg cggacttgga gaaagtgttt gcggagcaca agatctccta      420

cagcggccag ttcttggtca aatccggcta cgccttcgtg gactgcccgg acgagcactg      480

ggcgatgaag gccatcgaaa ctttctccgg gaaagtagaa ttacaaggaa aacgcttaga      540

gattgaacat tcggtgccca aaaaacaaag gagccggaaa attcaaatcc gaaatattcc      600

accccagctc cgatgggaag tactggacag cctgctggct cagtatggta cagtagagaa      660

ctgtgagcaa gtgaacaccg agagtgagac ggcagtggtg aatgtcacct attccaaccg      720

ggagcagacc aggcaagcca tcatgaagct gaatggccac cagttggaga accatgccct      780

gaaggtctcc tacatccccg atgagcagat agcacaggga cctgagaatg ggcgccgagg      840

gggctttggc tctcggggtc agccccgcca gggctcacct gtggcagcgg gggccccagc      900

caagcagcag caagtggaca tcccccttcg gctcctggtg cccacccagt atgtgggtgc      960

cattattggc aaggaggggg ccaccatccg caacatcaca aaacagaccc agtccaagat     1020

agacgtgcat aggaaggaga acgcaggtgc agctgaaaaa gccatcagtg tgcactccac     1080

ccctgagggc tgctcctccg cttgtaagat gatcttggag attatgcata aagaggctaa     1140

ggacaccaaa acggctgacg aggttcccct gaagatcctg gcccataata actttgtagg     1200

gcgtctcatt ggcaaggaag gacggaacct gaagaaggta gagcaagata ccgagacaaa     1260

aatcaccatc tcctcgttgc aagaccttac cctttacaac cctgagagga ccatcactgt     1320

gaagggggcc atcgagaatt gttgcagggc cgagcaggaa ataatgaaga aagttcggga     1380

ggcctatgag aatgatgtgg ctgccatgag cctgcagtct cacctgatcc ctggcctgaa     1440

cctggctgct gtaggtcttt tcccagcttc atccagcgca gtcccgccgc ctcccagcag     1500

cgttactggg gctgctccct atagctcctt tatgcaggct cccgagcagg agatggtgca     1560

ggtgtttatc cccgcccagg cagtgggcgc catcatcggc aagaaggggc agcacatcaa     1620

acagctctcc cggtttgcca gcgcctccat caagattgca ccacccgaaa cacctgactc     1680

caaagttcgt atggttatca tcactggacc gccagaggcc caattcaagg ctcagggaag     1740

aatctatggc aaactcaagg aggagaactt ctttggtccc aaggaggaag tgaagctgga     1800

gacccacata cgtgtgccag catcagcagc tggccgggtc attggcaaag gtggaaaaac     1860

ggtgaacgag ttgcagaatt tgacggcagc tgaggtggta gtaccaagag accagacccc     1920

tgatgagaac gaccaggtca tcgtgaaaat catcggacat ttctatgcca gtcagatggc     1980

tcaacggaag atccgagaca tcctggccca ggttaagcag cagcatcaga agggacagag     2040

taaccaggcc caggcacgga ggaagtgacc agcccctccc tgtcccttcg agtccaggac     2100

aacaacgggc agaaatcgag agtgtgctct ccccggcagg cctgagaatg agtgggaatc     2160

cgggacacct gggccgggct gtagatcagg tttgcccact tgattgagaa agatgttcca     2220

gtgaggaacc ctgatctctc agccccaaac acccacccaa ttggcccaac actgtctgcc     2280

cctcggggtg tcagaaattc tagcgcaagg cacttttaaa cgtggattgt ttaaagaagc     2340

tctccaggcc ccaccaagag ggtggatcac acctcagtgg gaagaaaaat aaaatttcct     2400

tcaggtttta aaaacatgca gagaggtgtt ttaatcagcc ttaaaggatg gttcatttct     2460

tgaccttaat gtttttccaa tcttcttccc cctacttggg taattgatta aaatacctcc     2520

atttacggcc tctttctata tttacactaa tttttttatc tttattgcta ccagaaaaaa     2580

atgcgaacga atgcattgct ttgcttacag tattgactca agggaaaaga actgtcagta     2640

tctgtagatt aattccaatc actccctaac caataggtac aatacggaat gaagaagagg     2700

ggaaaatggg gagaaagatg gttaaaatac ataataatcc acgtttaaaa ggagcgcact     2760

tgtggctgat ctatgccaga tcaccatctt caaattggca caactgaaat ttccccactc     2820

tgttggggct tccccaccac attcatgtcc ctctcccgtg taggtttcac attatgtcca     2880

ggtgcacata ggtggtattg aatgctcagc agggtagggg ctgaccactg tccctgattc     2940

ccatcgttct caggcggatt ttatattttt ttaaagtcta ttttaatgat tggatatgag     3000

cactgggaag gggacgctaa ctccccttga taaagtctcg gttccatgga ggacttgagt     3060

ggccccaaag gctgccacgg tgccctcacc ccagcccatg tgctcccata agggctggtt     3120

cctagaggca ggggttgtgg ggcactccca gccacggcac tgttaccttg gtggtgggac     3180

ttggaaccca accctgagct cccgataaag ctaaagtcca tcatctggca aattcagtaa     3240

attggagagt acttgcttct gtttgtatct gagaggaatt tttaactgac ggcttctgtc     3300

tccatgaatc attatcagca tgatgaaagg tgtgtctaaa aaacaattca gaataccagc     3360

agcattgtac agcaaggggt aaataagctt aatttattaa tttaccaggc ttaattaaga     3420

tcccatggag tgtttagccc ttgtgggaga cagaagccat cagttaaatg aggttaggcc     3480

tctcctccta atatactgat tgacaatgca tattagccag gtaatgcact ttagctaccc     3540

tggacaatgc tatcaagtgt gctgggaagg gaggaaggcc tctctacata tggaaaagcc     3600

catgcgtgga gttcccctcc tttcaacatt gcaacaacag taacaacaag acaaccgcaa     3660

catgtgggcg tagtcaggca atgctgtgtg cgaagtaaac tacctcaagg tatgaagtta     3720

cctcagcaat tattttcctt tttgttcccc ccaaccccat taaaaaaatt tttttttgat     3780

ttttgttttt ttgcagcttg ctgatatttt atataaaaaa gaaaagcaaa gcaaaagaga     3840

agctgatagt cttgaatatt ttattttttt aatgaaaaga aaaaacaaga aagttatgtt     3900

tcataatttc ttacaacatg agccagtaac cctttaggaa ctctctatgg agaacaggcc     3960

tggtgggaaa ggctttgggg gctgccccct taggaggagg ctagtgctaa gagggaaggc     4020

ccaggtttga gagagcccag aggggcagag cccagagcct tgtttggccc tgatctctga     4080

cttctagagc cccagctgct ggcggctgct ggaatatcct acctgatagg attaaaaggc     4140

ctagtggagc tgggggctct cagtggttaa acaatgccca acaaccaacc agctggccct     4200

tggtctcctc tctttcctcc tttggttaaa gagcatctca gccagctttt cccaccagtg     4260

gtgctgttga gatattttaa aatattgcct ccgttttatc gaggagagaa ataataacta     4320

aaaaatatac cctttaaaaa aacctatatt tctctgtcta aaaatatggg agctgagatt     4380

ccgttcgtgg aaaaaagaca aggccaccct ctcgccctca gagaggtcca cctggtttgt     4440

cattgcaatg cttttcattt tttttttttg ttattgtttc atttcagttc cgtcttgcta     4500

ttcttcctaa tctatatcca tagatctaag gggcaaacag atactagtta actgccccca     4560

cctctgtctc cctgtcttct ttagatcggt ctgattgatt ttaaaagtgg acccaaactt     4620

agggaattct tgatttaggg tggctggtgg caaggagggg caggggatat ggggacgtga     4680

ctgggacagg ttcctgcctt atcattttct ccctaggaca ttcccttgta gcccccagaa     4740

ttgtctggcc caaattgaat agaagcagaa aaacatttag ggataacatc aggccagtag     4800

aattaagcct ctccacctgt cccaaccata aaaagggtct cccagctttc catctctggc     4860

tctatatgct ttatcccaaa acaaagcaga taacgttcag acgtcggcca tttagtaatt     4920

taaagcgaat ttccagcagc aagcatgctt tgatatctgg ttcagactat catcaggaag     4980

aaaaaaaaat cccacagtac ctgaaatgtg attgttgcag tgttcagttt ccttgggggc     5040

ctgctccctt cacaccttga gcccaagtcc ttttccgttg gctgattcag ctcccagaag     5100

agacgaggaa gtgtgtggca agggactgga aaacttcact tgcttggatt aggcaaggct     5160

ccactcattg ttgatatttg cccagcagga aaatcatgta agttatacca ccagaaagca     5220

aaaggagcat ggtttggtgg ttaaggttta gtgggatgaa ggacctgtct tggtgggccg     5280

ggccctcttg tgccccgtag gctaggtctt agggcaactc cttgccctcc tgctcagcac     5340

ctccatttcc ccatccttgg tgagataaca agctatcgcg aaaagcactt gggagatttg     5400

gatgatttga gaagagtgac ttaaaaaaaa tgcttctgtg ctctaagata tatatgtgtg     5460

tgtgtgtgct acatatatat ttttaagaaa ggaccatctc tttaggatat atttttaaat     5520

tctttgaaac acataaccaa aatggtttga ttcactgact gactttgaag ctgcatctgc     5580

cagttacacc ccaaatggct ttaatcccct ctcgggtctg gttgcctttt gcagtttggg     5640

ttgtggactc agctcctgtg aggggtctgg ttaggagaga gccattttta aggacaggga     5700

gttttatagc ccttttctac tttcctcccc tcctcccagt ccttatcaat cttttttcct     5760

ttttcctgac cccctccttc tggaggcagt tgggagctat ccttgtttat gcctcactat     5820

tggcagaaaa gaccccattt aaaacccaga gaacactgga gggggatgct ctagttggtt     5880

ctgtgtccat tttcctctgt gccaaagaca gacagacaga ggctgagaga ggctgttcct     5940

gaatcaaagc aatagccagc tttcgacaca tacctggctg tctgaggagg aaggcctcct     6000

ggaaactggg agctaagggc gaggcccttc ccttcagagg ctcctggggg attagggtgt     6060

ggtgtttgcc aagccaaggg gtagggagcc gagaaattgg tctgtcggct cctggttgca     6120

ctttggggaa ggagaggaag tttggggctc caggtagctc cctgttgtgg gactgctctg     6180

tcccctgccc ctactgcaga gatagcactg ccgagttccc ttcaggcctg gcagacgggc     6240

agtgaggagg ggcctcagtt agctctcaag ggtgccttcc cctcctccca acccagacat     6300

accctctgcc aaactgggaa ccagcagtgc tagtaactac ctcacagagc cccagagggc     6360

ctgcttgagc cttcttgctc cacaggagaa gctggtgcct ctaggcaacc ccttcctccc     6420

acctctcatc aggggtgggg gttctccttt ctttcccctg aagtgtttat ggggagatcc     6480

tagtggcttt gccattcaaa ccactcgact gtttgcctgt ttcttgaaaa ccagtagaag     6540

ggaaacagca cagcctgtca cagtaattgc aggaagattg aagaaaaatc ctcatcaatg     6600

ccaggggaca taaaagccat ttcccttcca aatactcgac aatttagatg cagaacattt     6660

ctctgtattc agacttagag taacaccagc tgaaaactgc agtttctttc ctttggatac     6720

ataaggcttc tctatcgggg tacgggacag ggaggaggcc tcatgtctga agggggattt     6780

aggggcgaga gccccagccc tgaccctcgg tcctgtgcac cgctttgggg cacagtctga     6840

tggcgccttt gctggcgcct tagtatggtt gactccggat ggacaaaaga aaaaaaattt     6900

tttttcttga atgaaatagc aggaagctcc tcgggagcat gtgttttgat taaccgcagg     6960

tgatggatgc tacgagtata aatggattaa ctacctcaat ccttacagta agattggaac     7020

taagggcagg gactcatgca taagggtatg aatcccagcc aggacaagtg agttgaggct     7080

tgtgccacaa aaggtttgtc cttggggaac aggcaggcct gccaggatcc cccccatatc     7140

gattgggctg ggagggctgg ccatgaggtc cccactttct gctttccttg cccatgtgtc     7200

acccctttgg cctccagctt gtccctctct cactttctat agctttgttg gaccagatgg     7260

tgaggaaagg aatggcctct tcccttctag agggggctgg ctggagtgag acctggggct     7320

tggcctggaa cccaccacac agccccaaag tcaggaagcc tggggaaacc agagctgaga     7380

cctcttcaac agggtttctt tgagatccta cacctccatt gggccctttt tcagtcttca     7440

atgggggccc agttggctct agaaggagaa gaggtgaagc aggatccttt gccctggggg     7500

agtctgaggg cgcggtcctt ggactcattc aggccgtctt tgtagttggg ggagttccac     7560

tgggcgatcc cagcccctcc ccacccaccc tctaatggac ctcctcatag aagccccatt     7620

tcacttttgt tttatctacc tcttagcaaa acaatagata aattaggtag tggcagctcc     7680

acttgcttag gttagggggg gaaaaagatt tctttttcca aaggaaaaaa atattacctt     7740

gagaatactt tccaaaaaat aaaattaaaa aaaaaaaaac caaaaaaaaa aatttttttt     7800

taaaagggag acattttcca gtgaccactg gattgtttta atttcccaag cttttttttc     7860

ccccataaat aagtttcact ctttggcgat tttcttcact tgtttaagat aacgtgctag     7920

ctattccaac aggtaacagc tttcacagtc tgcccctggc ctgtctcacc ccatccccca     7980

ccctattcct gccagtgagt ccttcctgtg cttctctccc ttctcccctc ccagccagct     8040

gacttcagtc acccctgtcc cccctcccct gccaataagc tcccccagga ataaaggctt     8100

tgttttgggg atgcttaaat cttgactggc acttcccggc tgtgggggct ggggagccac     8160

ttgtaacatt tctgtgcaga ttttatgtta gccactgcta tgtaaaagca cgttcaaaat     8220

gaatttcagc agattatgtg ttaccataat gaataaacgt cctctatcac catttggagt     8280

ctcccttttc tccaggatct tgatcctggt ccccaaaacc agagtgaatc aaaagagctt     8340

cctcccctga ggcaaagtgg atttgtaagc agttctgaaa catcacttac tcagaagagg     8400

gaacgatgta ttttgatgag tgcaaattgg gaagagctgg aggcctactg cttgggacag     8460

tttttttttt tttttttttt ttaaatatga gtgctagctt attctgtaat tgcggcaact     8520

ttgaaaattg tattttactg gaaatctgcc agccatcacc acccgatttt gattgtatcc     8580

ttcctcccat cctttaatct gttcattgct ttgggggagg tggggcagct ggctcacacg     8640

ttggagtttg ttctttgatg gatgaacgaa cactccagtt ttctttcccg tgaaggttgt     8700

ttcagccaca aaccacttca ttttgctgtt tcaatttcaa aataaaagga aacttatatt     8760

gaaagacaa                                                             8769


<210>  2
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asn Lys Leu Tyr Ile Gly Asn Leu Asn Glu Ser Val Thr Pro Ala 
1               5                   10                  15      


Asp Leu Glu Lys Val Phe Ala Glu His Lys Ile Ser Tyr Ser Gly Gln 
            20                  25                  30          


Phe Leu Val Lys Ser Gly Tyr Ala Phe Val Asp Cys Pro Asp Glu His 
        35                  40                  45              


Trp Ala Met Lys Ala Ile Glu Thr Phe Ser Gly Lys Val Glu Leu Gln 
    50                  55                  60                  


Gly Lys Arg Leu Glu Ile Glu His Ser Val Pro Lys Lys Gln Arg Ser 
65                  70                  75                  80  


Arg Lys Ile Gln Ile Arg Asn Ile Pro Pro Gln Leu Arg Trp Glu Val 
                85                  90                  95      


Leu Asp Ser Leu Leu Ala Gln Tyr Gly Thr Val Glu Asn Cys Glu Gln 
            100                 105                 110         


Val Asn Thr Glu Ser Glu Thr Ala Val Val Asn Val Thr Tyr Ser Asn 
        115                 120                 125             


Arg Glu Gln Thr Arg Gln Ala Ile Met Lys Leu Asn Gly His Gln Leu 
    130                 135                 140                 


Glu Asn His Ala Leu Lys Val Ser Tyr Ile Pro Asp Glu Gln Ile Ala 
145                 150                 155                 160 


Gln Gly Pro Glu Asn Gly Arg Arg Gly Gly Phe Gly Ser Arg Gly Gln 
                165                 170                 175     


Pro Arg Gln Gly Ser Pro Val Ala Ala Gly Ala Pro Ala Lys Gln Gln 
            180                 185                 190         


Gln Val Asp Ile Pro Leu Arg Leu Leu Val Pro Thr Gln Tyr Val Gly 
        195                 200                 205             


Ala Ile Ile Gly Lys Glu Gly Ala Thr Ile Arg Asn Ile Thr Lys Gln 
    210                 215                 220                 


Thr Gln Ser Lys Ile Asp Val His Arg Lys Glu Asn Ala Gly Ala Ala 
225                 230                 235                 240 


Glu Lys Ala Ile Ser Val His Ser Thr Pro Glu Gly Cys Ser Ser Ala 
                245                 250                 255     


Cys Lys Met Ile Leu Glu Ile Met His Lys Glu Ala Lys Asp Thr Lys 
            260                 265                 270         


Thr Ala Asp Glu Val Pro Leu Lys Ile Leu Ala His Asn Asn Phe Val 
        275                 280                 285             


Gly Arg Leu Ile Gly Lys Glu Gly Arg Asn Leu Lys Lys Val Glu Gln 
    290                 295                 300                 


Asp Thr Glu Thr Lys Ile Thr Ile Ser Ser Leu Gln Asp Leu Thr Leu 
305                 310                 315                 320 


Tyr Asn Pro Glu Arg Thr Ile Thr Val Lys Gly Ala Ile Glu Asn Cys 
                325                 330                 335     


Cys Arg Ala Glu Gln Glu Ile Met Lys Lys Val Arg Glu Ala Tyr Glu 
            340                 345                 350         


Asn Asp Val Ala Ala Met Ser Leu Gln Ser His Leu Ile Pro Gly Leu 
        355                 360                 365             


Asn Leu Ala Ala Val Gly Leu Phe Pro Ala Ser Ser Ser Ala Val Pro 
    370                 375                 380                 


Pro Pro Pro Ser Ser Val Thr Gly Ala Ala Pro Tyr Ser Ser Phe Met 
385                 390                 395                 400 


Gln Ala Pro Glu Gln Glu Met Val Gln Val Phe Ile Pro Ala Gln Ala 
                405                 410                 415     


Val Gly Ala Ile Ile Gly Lys Lys Gly Gln His Ile Lys Gln Leu Ser 
            420                 425                 430         


Arg Phe Ala Ser Ala Ser Ile Lys Ile Ala Pro Pro Glu Thr Pro Asp 
        435                 440                 445             


Ser Lys Val Arg Met Val Ile Ile Thr Gly Pro Pro Glu Ala Gln Phe 
    450                 455                 460                 


Lys Ala Gln Gly Arg Ile Tyr Gly Lys Leu Lys Glu Glu Asn Phe Phe 
465                 470                 475                 480 


Gly Pro Lys Glu Glu Val Lys Leu Glu Thr His Ile Arg Val Pro Ala 
                485                 490                 495     


Ser Ala Ala Gly Arg Val Ile Gly Lys Gly Gly Lys Thr Val Asn Glu 
            500                 505                 510         


Leu Gln Asn Leu Thr Ala Ala Glu Val Val Val Pro Arg Asp Gln Thr 
        515                 520                 525             


Pro Asp Glu Asn Asp Gln Val Ile Val Lys Ile Ile Gly His Phe Tyr 
    530                 535                 540                 


Ala Ser Gln Met Ala Gln Arg Lys Ile Arg Asp Ile Leu Ala Gln Val 
545                 550                 555                 560 


Lys Gln Gln His Gln Lys Gly Gln Ser Asn Gln Ala Gln Ala Arg Arg 
                565                 570                 575     


Lys 
    


<210>  3
<211>  3676
<212>  DNA
<213>  Homo sapiens

<400>  3
gagagacgag ggcagcggag gaggcgagga gcgccgggta ccgggccggg ggagccgcgg       60

gctctcgggg aagagacgga tgatgaacaa gctttacatc gggaacctga gccccgccgt      120

caccgccgac gacctccggc agctctttgg ggacaggaag ctgcccctgg cgggacaggt      180

cctgctgaag tccggctacg ccttcgtgga ctaccccgac cagaactggg ccatccgcgc      240

catcgagacc ctctcgggta aagtggaatt gcatgggaaa atcatggaag ttgattactc      300

agtctctaaa aagctaagga gcaggaaaat tcagattcga aacatccctc ctcacctgca      360

gtgggaggtg ttggatggac ttttggctca atatgggaca gtggagaatg tggaacaagt      420

caacacagac acagaaaccg ccgttgtcaa cgtcacatat gcaacaagag aagaagcaaa      480

aatagccatg gagaagctaa gcgggcatca gtttgagaac tactccttca agatttccta      540

catcccggat gaagaggtga gctccccttc gccccctcag cgagcccagc gtggggacca      600

ctcttcccgg gagcaaggcc acgcccctgg gggcacttct caggccagac agattgattt      660

cccgctgcgg atcctggtcc ccacccagtt tgttggtgcc atcatcggaa aggagggctt      720

gaccataaag aacatcacta agcagaccca gtcccgggta gatatccata gaaaagagaa      780

ctctggagct gcagagaagc ctgtcaccat ccatgccacc ccagagggga cttctgaagc      840

atgccgcatg attcttgaaa tcatgcagaa agaggcagat gagaccaaac tagccgaaga      900

gattcctctg aaaatcttgg cacacaatgg cttggttgga agactgattg gaaaagaagg      960

cagaaatttg aagaaaattg aacatgaaac agggaccaag ataacaatct catctttgca     1020

ggatttgagc atatacaacc cggaaagaac catcactgtg aagggcacag ttgaggcctg     1080

tgccagtgct gagatagaga ttatgaagaa gctgcgtgag gcctttgaaa atgatatgct     1140

ggctgttaac caacaagcca atctgatccc agggttgaac ctcagcgcac ttggcatctt     1200

ttcaacagga ctgtccgtgc tatctccacc agcagggccc cgcggagctc cccccgctgc     1260

cccctaccac cccttcacta cccactccgg atacttctcc agcctgtacc cccatcacca     1320

gtttggcccg ttcccgcatc atcactctta tccagagcag gagattgtga atctcttcat     1380

cccaacccag gctgtgggcg ccatcatcgg gaagaagggg gcacacatca aacagctggc     1440

gagattcgcc ggagcctcta tcaagattgc ccctgcggaa ggcccagacg tcagcgaaag     1500

gatggtcatc atcaccgggc caccggaagc ccagttcaag gcccagggac ggatctttgg     1560

gaaactgaaa gaggaaaact tctttaaccc caaagaagaa gtgaagctgg aagcgcatat     1620

cagagtgccc tcttccacag ctggccgggt gattggcaaa ggtggcaaga ccgtgaacga     1680

actgcagaac ttaaccagtg cagaagtcat cgtgcctcgt gaccaaacgc cagatgaaaa     1740

tgaggaagtg atcgtcagaa ttatcgggca cttctttgct agccagactg cacagcgcaa     1800

gatcagggaa attgtacaac aggtgaagca gcaggagcag aaataccctc agggagtcgc     1860

ctcacagcgc agcaagtgag gctcccacag gcaccagcaa aacaacggat gaatgtagcc     1920

cttccaacac ctgacagaat gagaccaaac gcagccagcc agatcgggag caaaccaaag     1980

accatctgag gaatgagaag tctgcggagg cggccaggga ctctgccgag gccctgagaa     2040

ccccaggggc cgaggagggg cggggaaggt cagccaggtt tgccagaacc accgagcccc     2100

gcctcccgcc ccccagggct tctgcaggct tcagccatcc acttcaccat ccactcggat     2160

ctctcctgaa ctcccacgac gctatccctt ttagttgaac taacataggt gaacgtgttc     2220

aaagccaagc aaaatgcaca ccctttttct gtggcaaatc gtctctgtac atgtgtgtac     2280

atattagaaa gggaagatgt taagatatgt ggcctgtggg ttacacaggg tgcctgcagc     2340

ggtaatatat tttagaaata atatatcaaa taactcaact aactccaatt tttaatcaat     2400

tattaatttt tttttctttt taaagagaaa gcaggctttt ctagacttta aagaataaag     2460

tctttgggag gtctcacggt gtagagagga gctttgaggc cacccgcaca aaattcaccc     2520

agagggaaat ctcgtcggaa ggacactcac ggcagttctg gatcacctgt gtatgtcaac     2580

agaagggata ccgtctcctt gaagaggaaa ctctgtcact cctcatgcct gtctagctca     2640

tacacccatt tctctttgct tcacaggttt taaactggtt ttttgcatac tgctatataa     2700

ttctctgtct ctctctgttt atctctcccc tccctcccct ccccttcttc tccatctcca     2760

ttcttttgaa tttcctcatc cctccatctc aatcccgtat ctacgcaccc cccccccccc     2820

aggcaaagca gtgctctgag tatcacatca cacaaaagga acaaaagcga aacacacaaa     2880

ccagcctcaa cttacacttg gttactcaaa agaacaagag tcaatggtac ttgtcctagc     2940

gttttggaag aggaaaacag gaacccacca aaccaaccaa tcaaccaaac aaagaaaaaa     3000

ttccacaatg aaagaatgta ttttgtcttt ttgcattttg gtgtataagc catcaatatt     3060

cagcaaaatg attcctttct ttaaaaaaaa aaaatgtgga ggaaagtaga aatttaccaa     3120

ggttgttggc ccagggcgtt aaattcacag atttttttaa cgagaaaaac acacagaaga     3180

agctacctca ggtgttttta cctcagcacc ttgctcttgt gtttccctta gagattttgt     3240

aaagctgata gttggagcat ttttttattt ttttaataaa aatgagttgg aaaaaaaata     3300

agatatcaac tgccagcctg gagaaggtga cagtccaagt gtgcaacagc tgttctgaat     3360

tgtcttccgc tagccaagaa cctatatggc cttcttttgg acaaaccttg aaaatgttta     3420

tttaaaaaaa aaaaagatga caaagaaaaa cagagagaga gaatattgga gatgtcctga     3480

attttaatag ggtacgcgcc attagggctt tttgcgctaa aggatgaaca tgtactggtt     3540

tatgtggaca agccattata ccaccagact gcaatgccag tttcctctac tgcaaacagt     3600

gttctgtgac aaaaaaaaaa aaaaaaaaaa gaaaaaaaaa gaaaaaacag aaatatatcc     3660

agctaacaag aaaaaa                                                     3676


<210>  4
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Met Asn Lys Leu Tyr Ile Gly Asn Leu Ser Pro Ala Val Thr Ala 
1               5                   10                  15      


Asp Asp Leu Arg Gln Leu Phe Gly Asp Arg Lys Leu Pro Leu Ala Gly 
            20                  25                  30          


Gln Val Leu Leu Lys Ser Gly Tyr Ala Phe Val Asp Tyr Pro Asp Gln 
        35                  40                  45              


Asn Trp Ala Ile Arg Ala Ile Glu Thr Leu Ser Gly Lys Val Glu Leu 
    50                  55                  60                  


His Gly Lys Ile Met Glu Val Asp Tyr Ser Val Ser Lys Lys Leu Arg 
65                  70                  75                  80  


Ser Arg Lys Ile Gln Ile Arg Asn Ile Pro Pro His Leu Gln Trp Glu 
                85                  90                  95      


Val Leu Asp Gly Leu Leu Ala Gln Tyr Gly Thr Val Glu Asn Val Glu 
            100                 105                 110         


Gln Val Asn Thr Asp Thr Glu Thr Ala Val Val Asn Val Thr Tyr Ala 
        115                 120                 125             


Thr Arg Glu Glu Ala Lys Ile Ala Met Glu Lys Leu Ser Gly His Gln 
    130                 135                 140                 


Phe Glu Asn Tyr Ser Phe Lys Ile Ser Tyr Ile Pro Asp Glu Glu Val 
145                 150                 155                 160 


Ser Ser Pro Ser Pro Pro Gln Arg Ala Gln Arg Gly Asp His Ser Ser 
                165                 170                 175     


Arg Glu Gln Gly His Ala Pro Gly Gly Thr Ser Gln Ala Arg Gln Ile 
            180                 185                 190         


Asp Phe Pro Leu Arg Ile Leu Val Pro Thr Gln Phe Val Gly Ala Ile 
        195                 200                 205             


Ile Gly Lys Glu Gly Leu Thr Ile Lys Asn Ile Thr Lys Gln Thr Gln 
    210                 215                 220                 


Ser Arg Val Asp Ile His Arg Lys Glu Asn Ser Gly Ala Ala Glu Lys 
225                 230                 235                 240 


Pro Val Thr Ile His Ala Thr Pro Glu Gly Thr Ser Glu Ala Cys Arg 
                245                 250                 255     


Met Ile Leu Glu Ile Met Gln Lys Glu Ala Asp Glu Thr Lys Leu Ala 
            260                 265                 270         


Glu Glu Ile Pro Leu Lys Ile Leu Ala His Asn Gly Leu Val Gly Arg 
        275                 280                 285             


Leu Ile Gly Lys Glu Gly Arg Asn Leu Lys Lys Ile Glu His Glu Thr 
    290                 295                 300                 


Gly Thr Lys Ile Thr Ile Ser Ser Leu Gln Asp Leu Ser Ile Tyr Asn 
305                 310                 315                 320 


Pro Glu Arg Thr Ile Thr Val Lys Gly Thr Val Glu Ala Cys Ala Ser 
                325                 330                 335     


Ala Glu Ile Glu Ile Met Lys Lys Leu Arg Glu Ala Phe Glu Asn Asp 
            340                 345                 350         


Met Leu Ala Val Asn Gln Gln Ala Asn Leu Ile Pro Gly Leu Asn Leu 
        355                 360                 365             


Ser Ala Leu Gly Ile Phe Ser Thr Gly Leu Ser Val Leu Ser Pro Pro 
    370                 375                 380                 


Ala Gly Pro Arg Gly Ala Pro Pro Ala Ala Pro Tyr His Pro Phe Thr 
385                 390                 395                 400 


Thr His Ser Gly Tyr Phe Ser Ser Leu Tyr Pro His His Gln Phe Gly 
                405                 410                 415     


Pro Phe Pro His His His Ser Tyr Pro Glu Gln Glu Ile Val Asn Leu 
            420                 425                 430         


Phe Ile Pro Thr Gln Ala Val Gly Ala Ile Ile Gly Lys Lys Gly Ala 
        435                 440                 445             


His Ile Lys Gln Leu Ala Arg Phe Ala Gly Ala Ser Ile Lys Ile Ala 
    450                 455                 460                 


Pro Ala Glu Gly Pro Asp Val Ser Glu Arg Met Val Ile Ile Thr Gly 
465                 470                 475                 480 


Pro Pro Glu Ala Gln Phe Lys Ala Gln Gly Arg Ile Phe Gly Lys Leu 
                485                 490                 495     


Lys Glu Glu Asn Phe Phe Asn Pro Lys Glu Glu Val Lys Leu Glu Ala 
            500                 505                 510         


His Ile Arg Val Pro Ser Ser Thr Ala Gly Arg Val Ile Gly Lys Gly 
        515                 520                 525             


Gly Lys Thr Val Asn Glu Leu Gln Asn Leu Thr Ser Ala Glu Val Ile 
    530                 535                 540                 


Val Pro Arg Asp Gln Thr Pro Asp Glu Asn Glu Glu Val Ile Val Arg 
545                 550                 555                 560 


Ile Ile Gly His Phe Phe Ala Ser Gln Thr Ala Gln Arg Lys Ile Arg 
                565                 570                 575     


Glu Ile Val Gln Gln Val Lys Gln Gln Glu Gln Lys Tyr Pro Gln Gly 
            580                 585                 590         


Val Ala Ser Gln Arg Ser Lys 
        595                 


<210>  5
<211>  4168
<212>  DNA
<213>  Homo sapiens

<400>  5
aagacttagg aagactggtg gatgcgtttg ggttgtagct aggctttttc ttttctttct       60

cttttaaaac acatctagac aaggaaaaaa caagcctcgg atctgatttt tcactcctcg      120

ttcttgtgct tggttcttac tgtgtttgtg tattttaaag gcgagaagac gaggggaaca      180

aaaccagctg gatccatcca tcaccgtggg tggttttaat ttttcgtttt ttctcgttat      240

ttttttttaa acaaccactc ttcacaatga acaaactgta tatcggaaac ctcagcgaga      300

acgccgcccc ctcggaccta gaaagtatct tcaaggacgc caagatcccg gtgtcgggac      360

ccttcctggt gaagactggc tacgcgttcg tggactgccc ggacgagagc tgggccctca      420

aggccatcga ggcgctttca ggtaaaatag aactgcacgg gaaacccata gaagttgagc      480

actcggtccc aaaaaggcaa aggattcgga aacttcagat acgaaatatc ccgcctcatt      540

tacagtggga ggtgctggat agtttactag tccagtatgg agtggtggag agctgtgagc      600

aagtgaacac tgactcggaa actgcagttg taaatgtaac ctattccagt aaggaccaag      660

ctagacaagc actagacaaa ctgaatggat ttcagttaga gaatttcacc ttgaaagtag      720

cctatatccc tgatgaaatg gccgcccagc aaaacccctt gcagcagccc cgaggtcgcc      780

gggggcttgg gcagaggggc tcctcaaggc aggggtctcc aggatccgta tccaagcaga      840

aaccatgtga tttgcctctg cgcctgctgg ttcccaccca atttgttgga gccatcatag      900

gaaaagaagg tgccaccatt cggaacatca ccaaacagac ccagtctaaa atcgatgtcc      960

accgtaaaga aaatgcgggg gctgctgaga agtcgattac tatcctctct actcctgaag     1020

gcacctctgc ggcttgtaag tctattctgg agattatgca taaggaagct caagatataa     1080

aattcacaga agagatcccc ttgaagattt tagctcataa taactttgtt ggacgtctta     1140

ttggtaaaga aggaagaaat cttaaaaaaa ttgagcaaga cacagacact aaaatcacga     1200

tatctccatt gcaggaattg acgctgtata atccagaacg cactattaca gttaaaggca     1260

atgttgagac atgtgccaaa gctgaggagg agatcatgaa gaaaatcagg gagtcttatg     1320

aaaatgatat tgcttctatg aatcttcaag cacatttaat tcctggatta aatctgaacg     1380

ccttgggtct gttcccaccc acttcaggga tgccacctcc cacctcaggg cccccttcag     1440

ccatgactcc tccctacccg cagtttgagc aatcagaaac ggagactgtt catctgttta     1500

tcccagctct atcagtcggt gccatcatcg gcaagcaggg ccagcacatc aagcagcttt     1560

ctcgctttgc tggagcttca attaagattg ctccagcgga agcaccagat gctaaagtga     1620

ggatggtgat tatcactgga ccaccagagg ctcagttcaa ggctcaggga agaatttatg     1680

gaaaaattaa agaagaaaac tttgttagtc ctaaagaaga ggtgaaactt gaagctcata     1740

tcagagtgcc atcctttgct gctggcagag ttattggaaa aggaggcaaa acggtgaatg     1800

aacttcagaa tttgtcaagt gcagaagttg ttgtccctcg tgaccagaca cctgatgaga     1860

atgaccaagt ggttgtcaaa ataactggtc acttctatgc ttgccaggtt gcccagagaa     1920

aaattcagga aattctgact caggtaaagc agcaccaaca acagaaggct ctgcaaagtg     1980

gaccacctca gtcaagacgg aagtaaaggc tcaggaaaca gcccaccaca gaggcagatg     2040

ccaaaccaaa gacagattgc ttaaccaaca gatgggcgct gaccccctat ccagaatcac     2100

atgcacaagt ttttacctag ccagttgttt ctgaggacca ggcaactttt gaactcctgt     2160

ctctgtgaga atgtatactt tatgctctct gaaatgtatg acacccagct ttaaaacaaa     2220

caaacaaaca aacaaaaaaa gggtggggga gggagggaaa gagaagagct ctgcacttcc     2280

ctttgttgta gtctcacagt ataacagata ttctaattct tcttaatatt cccccataat     2340

gccagaaatt ggcttaatga tgctttcact aaattcatca aatagattgc tcctaaatcc     2400

aattgttaaa attggatcag aataattatc acaggaactt aaatgttaag ccattagcat     2460

agaaaaactg ttctcagttt tatttttacc taacactaac atgagtaacc taagggaagt     2520

gctgaatggt gttggcaggg gtattaaacg tgcattttta ctcaactacc tcaggtattc     2580

agtaatacaa tgaaaagcaa aattgttcct tttttttgaa aattttatat actttataat     2640

gatagaagtc caaccgtttt ttaaaaaata aatttaaaat ttaacagcaa tcagctaaca     2700

ggcaaattaa gatttttact tctggctggt gacagtaaag ctggaaaatt aatttcaggg     2760

ttttttgagg cttttgacac agttattagt taaatcaaat gttcaaaaat acggagcagt     2820

gcctagtatc tggagagcag cactaccatt tattctttca tttatagttg ggaaagtttt     2880

tgacggtact aacaaagtgg tcgcaggaga ttttggaacg gctggtttaa atggcttcag     2940

gagacttcag ttttttgttt agctacatga ttgaatgcat aataaatgct ttgtgcttct     3000

gactatcaat acctaaagaa agtgcatcag tgaagagatg caagactttc aactgactgg     3060

caaaaagcaa gctttagctt gtcttatagg atgcttagtt tgccactaca cttcagacca     3120

atgggacagt catagatggt gtgacagtgt ttaaacgcaa caaaaggcta catttccatg     3180

gggccagcac tgtcatgagc ctcactaagc tattttgaag atttttaagc actgataaat     3240

taaaaaaaaa aaattagact ccaccttaag tagtaaagta taacaggatt tctgtatact     3300

gtgcaatcag ttctttgaaa aaaaagtcaa aagatagaga atacaagaaa agtttttggg     3360

atataatttg aatgactgtg aaaacatatg acctttgata acgaactcat ttgctcactc     3420

cttgacagca aagcccagta cgtacaattg tgttgggtgt gggtggtctc caaggccacg     3480

ctgctctctg aattgatttt ttgagttttg tttgtaagat gatcacagtc atgttacact     3540

gatctaaagg acatatatat aaccctttaa aaaaaaaatc actgcctcat tcttatttca     3600

agatgaattt ctatacagac tagatgtttt tctgaagatc aattagacat tttgaaaatg     3660

atttaaagtg ttttccttaa tgttctctga aaacaagttt cttttgtagt tttaaccaaa     3720

aaagtgccct ttttgtcact ggattctcct agcattcatg attttttttt catacaatga     3780

attaaaattg ctaaaatcat ggactggctt tctggttgga tttcaggtaa gatgtgttta     3840

aggccagagc ttttctcagt atttgatttt tttccccaat atttgatttt ttaaaaatat     3900

acacataggt gctgcattta tatctgctgg tttaaattct gtcatatttc acttctagcc     3960

ttttagtatg gcaaatcata ttttactttt acttaagcat ttgtaatttg gagtatctgg     4020

tactagctaa gaaataattc tataattgag ttttgtactc accatatatg gatcattcct     4080

catgtataat gtgccccaaa tgcagcttca ttttccagat accttgacgc agaataaatt     4140

ttttcatcat ttaggtgcaa aaaaaaaa                                        4168


<210>  6
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asn Lys Leu Tyr Ile Gly Asn Leu Ser Glu Asn Ala Ala Pro Ser 
1               5                   10                  15      


Asp Leu Glu Ser Ile Phe Lys Asp Ala Lys Ile Pro Val Ser Gly Pro 
            20                  25                  30          


Phe Leu Val Lys Thr Gly Tyr Ala Phe Val Asp Cys Pro Asp Glu Ser 
        35                  40                  45              


Trp Ala Leu Lys Ala Ile Glu Ala Leu Ser Gly Lys Ile Glu Leu His 
    50                  55                  60                  


Gly Lys Pro Ile Glu Val Glu His Ser Val Pro Lys Arg Gln Arg Ile 
65                  70                  75                  80  


Arg Lys Leu Gln Ile Arg Asn Ile Pro Pro His Leu Gln Trp Glu Val 
                85                  90                  95      


Leu Asp Ser Leu Leu Val Gln Tyr Gly Val Val Glu Ser Cys Glu Gln 
            100                 105                 110         


Val Asn Thr Asp Ser Glu Thr Ala Val Val Asn Val Thr Tyr Ser Ser 
        115                 120                 125             


Lys Asp Gln Ala Arg Gln Ala Leu Asp Lys Leu Asn Gly Phe Gln Leu 
    130                 135                 140                 


Glu Asn Phe Thr Leu Lys Val Ala Tyr Ile Pro Asp Glu Met Ala Ala 
145                 150                 155                 160 


Gln Gln Asn Pro Leu Gln Gln Pro Arg Gly Arg Arg Gly Leu Gly Gln 
                165                 170                 175     


Arg Gly Ser Ser Arg Gln Gly Ser Pro Gly Ser Val Ser Lys Gln Lys 
            180                 185                 190         


Pro Cys Asp Leu Pro Leu Arg Leu Leu Val Pro Thr Gln Phe Val Gly 
        195                 200                 205             


Ala Ile Ile Gly Lys Glu Gly Ala Thr Ile Arg Asn Ile Thr Lys Gln 
    210                 215                 220                 


Thr Gln Ser Lys Ile Asp Val His Arg Lys Glu Asn Ala Gly Ala Ala 
225                 230                 235                 240 


Glu Lys Ser Ile Thr Ile Leu Ser Thr Pro Glu Gly Thr Ser Ala Ala 
                245                 250                 255     


Cys Lys Ser Ile Leu Glu Ile Met His Lys Glu Ala Gln Asp Ile Lys 
            260                 265                 270         


Phe Thr Glu Glu Ile Pro Leu Lys Ile Leu Ala His Asn Asn Phe Val 
        275                 280                 285             


Gly Arg Leu Ile Gly Lys Glu Gly Arg Asn Leu Lys Lys Ile Glu Gln 
    290                 295                 300                 


Asp Thr Asp Thr Lys Ile Thr Ile Ser Pro Leu Gln Glu Leu Thr Leu 
305                 310                 315                 320 


Tyr Asn Pro Glu Arg Thr Ile Thr Val Lys Gly Asn Val Glu Thr Cys 
                325                 330                 335     


Ala Lys Ala Glu Glu Glu Ile Met Lys Lys Ile Arg Glu Ser Tyr Glu 
            340                 345                 350         


Asn Asp Ile Ala Ser Met Asn Leu Gln Ala His Leu Ile Pro Gly Leu 
        355                 360                 365             


Asn Leu Asn Ala Leu Gly Leu Phe Pro Pro Thr Ser Gly Met Pro Pro 
    370                 375                 380                 


Pro Thr Ser Gly Pro Pro Ser Ala Met Thr Pro Pro Tyr Pro Gln Phe 
385                 390                 395                 400 


Glu Gln Ser Glu Thr Glu Thr Val His Leu Phe Ile Pro Ala Leu Ser 
                405                 410                 415     


Val Gly Ala Ile Ile Gly Lys Gln Gly Gln His Ile Lys Gln Leu Ser 
            420                 425                 430         


Arg Phe Ala Gly Ala Ser Ile Lys Ile Ala Pro Ala Glu Ala Pro Asp 
        435                 440                 445             


Ala Lys Val Arg Met Val Ile Ile Thr Gly Pro Pro Glu Ala Gln Phe 
    450                 455                 460                 


Lys Ala Gln Gly Arg Ile Tyr Gly Lys Ile Lys Glu Glu Asn Phe Val 
465                 470                 475                 480 


Ser Pro Lys Glu Glu Val Lys Leu Glu Ala His Ile Arg Val Pro Ser 
                485                 490                 495     


Phe Ala Ala Gly Arg Val Ile Gly Lys Gly Gly Lys Thr Val Asn Glu 
            500                 505                 510         


Leu Gln Asn Leu Ser Ser Ala Glu Val Val Val Pro Arg Asp Gln Thr 
        515                 520                 525             


Pro Asp Glu Asn Asp Gln Val Val Val Lys Ile Thr Gly His Phe Tyr 
    530                 535                 540                 


Ala Cys Gln Val Ala Gln Arg Lys Ile Gln Glu Ile Leu Thr Gln Val 
545                 550                 555                 560 


Lys Gln His Gln Gln Gln Lys Ala Leu Gln Ser Gly Pro Pro Gln Ser 
                565                 570                 575     


Arg Arg Lys 
            


<210>  7
<211>  24
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  CEBADOR IMP1-F

<400>  7
ggaaagtaga attacaagga aaac                                              24


<210>  8
<211>  18
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  CEBADOR IMP1-R

<400>  8
cggagctggg gtggaata                                                     18


<210>  9
<211>  20
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  IMP1-SONDA

<400>  9
tgaacattcg gtgcccaaaa                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  CEBADOR IMP2-F

<400>  10
gcagagaagc ctgtcaccat                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  CEBADOR IMP2-R

<400>  11
tggtccctgt ttcatgttca                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  IMP2-SONDA

<400>  12
ccaccccaga ggggacttct                                                   20


<210>  13
<211>  24
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  CEBADOR IMP3-F

<400>  13
agaactgcac gggaaaccca taga                                              24


<210>  14
<211>  22
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  CEBADOR IMP3-R

<400>  14
tcccactgta aatgaggcgg ga                                                22


<210>  15
<211>  22
<212>  DNA
<213>  Secuencia Artificial

<220>
<223>  IMP3-SONDA

<400>  15
agcactcggt cccaaaaagg ca                                                22


