                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       Ramot at Tel-Aviv University Ltd.
       ROTTER, Varda
       RIVLIN, Noa
       GEIGER, Tamar
 
<120>  STABILIZATION OF MUTANT P53 IN WILD TYPE CONFORMATION BY PROTEINS
        OF EMBRYONIC STEM CELLS

<130>  61665

<150>  US 61/969,319
<151>  2014-03-24

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  2591
<212>  DNA
<213>  Homo sapiens

<400>  1
gatgggattg gggttttccc ctcccatgtg ctcaagactg gcgctaaaag ttttgagctt       60

ctcaaaagtc tagagccacc gtccagggag caggtagctg ctgggctccg gggacacttt      120

gcgttcgggc tgggagcgtg ctttccacga cggtgacacg cttccctgga ttggcagcca      180

gactgccttc cgggtcactg ccatggagga gccgcagtca gatcctagcg tcgagccccc      240

tctgagtcag gaaacatttt cagacctatg gaaactactt cctgaaaaca acgttctgtc      300

ccccttgccg tcccaagcaa tggatgattt gatgctgtcc ccggacgata ttgaacaatg      360

gttcactgaa gacccaggtc cagatgaagc tcccagaatg ccagaggctg ctccccccgt      420

ggcccctgca ccagcagctc ctacaccggc ggcccctgca ccagccccct cctggcccct      480

gtcatcttct gtcccttccc agaaaaccta ccagggcagc tacggtttcc gtctgggctt      540

cttgcattct gggacagcca agtctgtgac ttgcacgtac tcccctgccc tcaacaagat      600

gttttgccaa ctggccaaga cctgccctgt gcagctgtgg gttgattcca cacccccgcc      660

cggcacccgc gtccgcgcca tggccatcta caagcagtca cagcacatga cggaggttgt      720

gaggcgctgc ccccaccatg agcgctgctc agatagcgat ggtctggccc ctcctcagca      780

tcttatccga gtggaaggaa atttgcgtgt ggagtatttg gatgacagaa acacttttcg      840

acatagtgtg gtggtgccct atgagccgcc tgaggttggc tctgactgta ccaccatcca      900

ctacaactac atgtgtaaca gttcctgcat gggcggcatg aaccggaggc ccatcctcac      960

catcatcaca ctggaagact ccagtggtaa tctactggga cggaacagct ttgaggtgcg     1020

tgtttgtgcc tgtcctggga gagaccggcg cacagaggaa gagaatctcc gcaagaaagg     1080

ggagcctcac cacgagctgc ccccagggag cactaagcga gcactgccca acaacaccag     1140

ctcctctccc cagccaaaga agaaaccact ggatggagaa tatttcaccc ttcagatccg     1200

tgggcgtgag cgcttcgaga tgttccgaga gctgaatgag gccttggaac tcaaggatgc     1260

ccaggctggg aaggagccag gggggagcag ggctcactcc agccacctga agtccaaaaa     1320

gggtcagtct acctcccgcc ataaaaaact catgttcaag acagaagggc ctgactcaga     1380

ctgacattct ccacttcttg ttccccactg acagcctccc acccccatct ctccctcccc     1440

tgccattttg ggttttgggt ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac     1500

ccaggacttc catttgcttt gtcccggggc tccactgaac aagttggcct gcactggtgt     1560

tttgttgtgg ggaggaggat ggggagtagg acataccagc ttagatttta aggtttttac     1620

tgtgagggat gtttgggaga tgtaagaaat gttcttgcag ttaagggtta gtttacaatc     1680

agccacattc taggtagggg cccacttcac cgtactaacc agggaagctg tccctcactg     1740

ttgaattttc tctaacttca aggcccatat ctgtgaaatg ctggcatttg cacctacctc     1800

acagagtgca ttgtgagggt taatgaaata atgtacatct ggccttgaaa ccacctttta     1860

ttacatgggg tctagaactt gacccccttg agggtgcttg ttccctctcc ctgttggtcg     1920

gtgggttggt agtttctaca gttgggcagc tggttaggta gagggagttg tcaagtctct     1980

gctggcccag ccaaaccctg tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa     2040

tctcacccca tcccacaccc tggaggattt catctcttgt atatgatgat ctggatccac     2100

caagacttgt tttatgctca gggtcaattt cttttttctt tttttttttt ttttttcttt     2160

ttctttgaga ctgggtctcg ctttgttgcc caggctggag tggagtggcg tgatcttggc     2220

ttactgcagc ctttgcctcc ccggctcgag cagtcctgcc tcagcctccg gagtagctgg     2280

gaccacaggt tcatgccacc atggccagcc aacttttgca tgttttgtag agatggggtc     2340

tcacagtgtt gcccaggctg gtctcaaact cctgggctca ggcgatccac ctgtctcagc     2400

ctcccagagt gctgggatta caattgtgag ccaccacgtc cagctggaag ggtcaacatc     2460

ttttacattc tgcaagcaca tctgcatttt caccccaccc ttcccctcct tctccctttt     2520

tatatcccat ttttatatcg atctcttatt ttacaataaa actttgctgc cacctgtgtg     2580

tctgaggggt g                                                          2591


<210>  2
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  3
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  4
<211>  1877
<212>  DNA
<213>  Mus musculus

<400>  4
tttcccctcc cacgtgctca ccctggctaa agttctgtag cttcagttca ttgggaccat       60

cctggctgta ggtagcgact acagttaggg ggcacctagc attcaggccc tcatcctcct      120

ccttcccagc agggtgtcac gcttctccga agactggatg actgccatgg aggagtcaca      180

gtcggatatc agcctcgagc tccctctgag ccaggagaca ttttcaggct tatggaaact      240

acttcctcca gaagatatcc tgccatcacc tcactgcatg gacgatctgt tgctgcccca      300

ggatgttgag gagttttttg aaggcccaag tgaagccctc cgagtgtcag gagctcctgc      360

agcacaggac cctgtcaccg agacccctgg gccagtggcc cctgccccag ccactccatg      420

gcccctgtca tcttttgtcc cttctcaaaa aacttaccag ggcaactatg gcttccacct      480

gggcttcctg cagtctggga cagccaagtc tgttatgtgc acgtactctc ctcccctcaa      540

taagctattc tgccagctgg cgaagacgtg ccctgtgcag ttgtgggtca gcgccacacc      600

tccagctggg agccgtgtcc gcgccatggc catctacaag aagtcacagc acatgacgga      660

ggtcgtgaga cgctgccccc accatgagcg ctgctccgat ggtgatggcc tggctcctcc      720

ccagcatctt atccgggtgg aaggaaattt gtatcccgag tatctggaag acaggcagac      780

ttttcgccac agcgtggtgg taccttatga gccacccgag gccggctctg agtataccac      840

catccactac aagtacatgt gtaatagctc ctgcatgggg ggcatgaacc gccgacctat      900

ccttaccatc atcacactgg aagactccag tgggaacctt ctgggacggg acagctttga      960

ggttcgtgtt tgtgcctgcc ctgggagaga ccgccgtaca gaagaagaaa atttccgcaa     1020

aaaggaagtc ctttgccctg aactgccccc agggagcgca aagagagcgc tgcccacctg     1080

cacaagcgcc tctcccccgc aaaagaaaaa accacttgat ggagagtatt tcaccctcaa     1140

gatccgcggg cgtaaacgct tcgagatgtt ccgggagctg aatgaggcct tagagttaaa     1200

ggatgcccat gctacagagg agtctggaga cagcagggct cactccagcc tccagcctag     1260

agccttccaa gccttgatca aggaggaaag cccaaactgc tagctcccat cacttcatcc     1320

ctcccctttt ctgtcttcct atagctacct gaagaccaag aagggccagt ctacttcccg     1380

ccataaaaaa acaatggtca agaaagtggg gcctgactca gactgactgc ctctgcatcc     1440

cgtccccatc accagcctcc ccctctcctt gctgtcttat gacttcaggg ctgagacaca     1500

atcctcccgg tcccttctgc tgcctttttt accttgtagc tagggctcag ccccctctct     1560

gagtagtggt tcctggccca agttggggaa taggttgata gttgtcaggt ctctgctggc     1620

ccagcgaaat tctatccagc cagttgttgg accctggcac ctacaatgaa atctcaccct     1680

accccacacc ctgtaagatt ctatcttggg ccctcatagg gtccatatcc tccagggcct     1740

actttccttc cattctgcaa agcctgtctg catttatcca ccccccaccc tgtctccctc     1800

tttttttttt ttttacccct ttttatatat caatttccta ttttacaata aaattttgtt     1860

atcacttaaa aaaaaaa                                                    1877


<210>  5
<211>  381
<212>  PRT
<213>  Mus musculus

<400>  5

Met Thr Ala Met Glu Glu Ser Gln Ser Asp Ile Ser Leu Glu Leu Pro 
1               5                   10                  15      


Leu Ser Gln Glu Thr Phe Ser Gly Leu Trp Lys Leu Leu Pro Pro Glu 
            20                  25                  30          


Asp Ile Leu Pro Ser Pro His Cys Met Asp Asp Leu Leu Leu Pro Gln 
        35                  40                  45              


Asp Val Glu Glu Phe Phe Glu Gly Pro Ser Glu Ala Leu Arg Val Ser 
    50                  55                  60                  


Gly Ala Pro Ala Ala Gln Asp Pro Val Thr Glu Thr Pro Gly Pro Val 
65                  70                  75                  80  


Ala Pro Ala Pro Ala Thr Pro Trp Pro Leu Ser Ser Phe Val Pro Ser 
                85                  90                  95      


Gln Lys Thr Tyr Gln Gly Asn Tyr Gly Phe His Leu Gly Phe Leu Gln 
            100                 105                 110         


Ser Gly Thr Ala Lys Ser Val Met Cys Thr Tyr Ser Pro Pro Leu Asn 
        115                 120                 125             


Lys Leu Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val 
    130                 135                 140                 


Ser Ala Thr Pro Pro Ala Gly Ser Arg Val Arg Ala Met Ala Ile Tyr 
145                 150                 155                 160 


Lys Lys Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His 
                165                 170                 175     


Glu Arg Cys Ser Asp Gly Asp Gly Leu Ala Pro Pro Gln His Leu Ile 
            180                 185                 190         


Arg Val Glu Gly Asn Leu Tyr Pro Glu Tyr Leu Glu Asp Arg Gln Thr 
        195                 200                 205             


Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Ala Gly Ser 
    210                 215                 220                 


Glu Tyr Thr Thr Ile His Tyr Lys Tyr Met Cys Asn Ser Ser Cys Met 
225                 230                 235                 240 


Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp 
                245                 250                 255     


Ser Ser Gly Asn Leu Leu Gly Arg Asp Ser Phe Glu Val Arg Val Cys 
            260                 265                 270         


Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Phe Arg Lys 
        275                 280                 285             


Lys Glu Val Leu Cys Pro Glu Leu Pro Pro Gly Ser Ala Lys Arg Ala 
    290                 295                 300                 


Leu Pro Thr Cys Thr Ser Ala Ser Pro Pro Gln Lys Lys Lys Pro Leu 
305                 310                 315                 320 


Asp Gly Glu Tyr Phe Thr Leu Lys Ile Arg Gly Arg Lys Arg Phe Glu 
                325                 330                 335     


Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala His Ala 
            340                 345                 350         


Thr Glu Glu Ser Gly Asp Ser Arg Ala His Ser Ser Leu Gln Pro Arg 
        355                 360                 365             


Ala Phe Gln Ala Leu Ile Lys Glu Glu Ser Pro Asn Cys 
    370                 375                 380     


<210>  6
<211>  387
<212>  PRT
<213>  Mus musculus

<400>  6

Met Glu Glu Ser Gln Ser Asp Ile Ser Leu Glu Leu Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Gly Leu Trp Lys Leu Leu Pro Pro Glu Asp Ile Leu 
            20                  25                  30          


Pro Ser Pro His Cys Met Asp Asp Leu Leu Leu Pro Gln Asp Val Glu 
        35                  40                  45              


Glu Phe Phe Glu Gly Pro Ser Glu Ala Leu Arg Val Ser Gly Ala Pro 
    50                  55                  60                  


Ala Ala Gln Asp Pro Val Thr Glu Thr Pro Gly Pro Val Ala Pro Ala 
65                  70                  75                  80  


Pro Ala Thr Pro Trp Pro Leu Ser Ser Phe Val Pro Ser Gln Lys Thr 
                85                  90                  95      


Tyr Gln Gly Asn Tyr Gly Phe His Leu Gly Phe Leu Gln Ser Gly Thr 
            100                 105                 110         


Ala Lys Ser Val Met Cys Thr Tyr Ser Pro Pro Leu Asn Lys Leu Phe 
        115                 120                 125             


Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Ser Ala Thr 
    130                 135                 140                 


Pro Pro Ala Gly Ser Arg Val Arg Ala Met Ala Ile Tyr Lys Lys Ser 
145                 150                 155                 160 


Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys 
                165                 170                 175     


Ser Asp Gly Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu 
            180                 185                 190         


Gly Asn Leu Tyr Pro Glu Tyr Leu Glu Asp Arg Gln Thr Phe Arg His 
        195                 200                 205             


Ser Val Val Val Pro Tyr Glu Pro Pro Glu Ala Gly Ser Glu Tyr Thr 
    210                 215                 220                 


Thr Ile His Tyr Lys Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met 
225                 230                 235                 240 


Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly 
                245                 250                 255     


Asn Leu Leu Gly Arg Asp Ser Phe Glu Val Arg Val Cys Ala Cys Pro 
            260                 265                 270         


Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Phe Arg Lys Lys Glu Val 
        275                 280                 285             


Leu Cys Pro Glu Leu Pro Pro Gly Ser Ala Lys Arg Ala Leu Pro Thr 
    290                 295                 300                 


Cys Thr Ser Ala Ser Pro Pro Gln Lys Lys Lys Pro Leu Asp Gly Glu 
305                 310                 315                 320 


Tyr Phe Thr Leu Lys Ile Arg Gly Arg Lys Arg Phe Glu Met Phe Arg 
                325                 330                 335     


Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala His Ala Thr Glu Glu 
            340                 345                 350         


Ser Gly Asp Ser Arg Ala His Ser Ser Tyr Leu Lys Thr Lys Lys Gly 
        355                 360                 365             


Gln Ser Thr Ser Arg His Lys Lys Thr Met Val Lys Lys Val Gly Pro 
    370                 375                 380                 


Asp Ser Asp 
385         


<210>  7
<211>  395
<212>  PRT
<213>  Mus musculus

<400>  7

Met Asp Arg Cys Lys Glu Asn Cys Val Ser Arg Pro Val Lys Thr Thr 
1               5                   10                  15      


Val Pro Phe Gly Pro Lys Arg Val Leu Val Thr Glu Gln Ile Pro Ser 
            20                  25                  30          


Gln Asn Leu Gly Ser Ala Ser Ser Gly Gln Ala Gln Arg Val Leu Cys 
        35                  40                  45              


Pro Ser Asn Ser Gln Arg Val Pro Ser Gln Ala Gln Lys Leu Gly Ala 
    50                  55                  60                  


Gly Gln Lys Pro Ala Pro Lys Gln Leu Pro Ala Ala Ser Val Pro Arg 
65                  70                  75                  80  


Pro Val Ser Arg Leu Asn Asn Pro Gln Lys Asn Glu Gln Pro Ala Ala 
                85                  90                  95      


Ser Gly Asn Asp Ser Glu Lys Glu Gln Ala Ser Leu Gln Lys Thr Glu 
            100                 105                 110         


Asp Thr Lys Lys Arg Gln Trp Thr Leu Glu Asp Phe Asp Ile Gly Arg 
        115                 120                 125             


Pro Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg Glu Arg 
    130                 135                 140                 


Gln Ser Lys Phe Ile Leu Ala Leu Lys Val Leu Phe Lys Thr Gln Leu 
145                 150                 155                 160 


Glu Lys Ala Asn Val Glu His Gln Leu Arg Arg Glu Val Glu Ile Gln 
                165                 170                 175     


Ser His Leu Arg His Pro Asn Ile Leu Arg Leu Tyr Gly Tyr Phe His 
            180                 185                 190         


Asp Ala Thr Arg Val Tyr Leu Ile Leu Glu Tyr Ala Pro Leu Gly Thr 
        195                 200                 205             


Val Tyr Arg Glu Leu Gln Lys Leu Ser Lys Phe Asp Glu Gln Arg Thr 
    210                 215                 220                 


Ala Thr Tyr Ile Thr Glu Leu Ala Asn Ala Leu Ser Tyr Cys His Ser 
225                 230                 235                 240 


Lys Arg Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Gly 
                245                 250                 255     


Ser Asn Gly Glu Leu Lys Ile Ala Asp Phe Gly Trp Ser Val His Ala 
            260                 265                 270         


Pro Ser Ser Arg Arg Thr Thr Met Cys Gly Thr Leu Asp Tyr Leu Pro 
        275                 280                 285             


Pro Glu Met Ile Glu Gly Arg Met His Asp Glu Lys Val Asp Leu Trp 
    290                 295                 300                 


Ser Leu Gly Val Leu Cys Tyr Glu Phe Leu Val Gly Met Pro Pro Phe 
305                 310                 315                 320 


Glu Ala His Thr Tyr Gln Glu Thr Tyr Arg Arg Ile Ser Arg Val Glu 
                325                 330                 335     


Phe Thr Phe Pro Asp Phe Val Thr Glu Gly Ala Arg Asp Leu Ile Ser 
            340                 345                 350         


Arg Leu Leu Lys His Asn Ala Ser Gln Arg Leu Thr Leu Ala Glu Val 
        355                 360                 365             


Leu Glu His Pro Trp Ile Lys Ala Asn Ser Ser Lys Pro Pro Thr Gly 
    370                 375                 380                 


His Thr Ser Lys Glu Pro Thr Ser Lys Ser Ser 
385                 390                 395 


<210>  8
<211>  2225
<212>  PRT
<213>  Mus musculus

<400>  8

Met Ala Ala Leu Val Leu Glu Asp Gly Ser Val Leu Gln Gly Arg Pro 
1               5                   10                  15      


Phe Gly Ala Ala Val Ser Thr Ala Gly Glu Val Val Phe Gln Thr Gly 
            20                  25                  30          


Met Val Gly Tyr Pro Glu Ala Leu Thr Asp Pro Ser Tyr Lys Ala Gln 
        35                  40                  45              


Ile Leu Val Leu Thr Tyr Pro Leu Ile Gly Asn Tyr Gly Ile Pro Ser 
    50                  55                  60                  


Asp Glu Glu Asp Glu Phe Gly Leu Ser Lys Trp Phe Glu Ser Ser Glu 
65                  70                  75                  80  


Ile His Val Ala Gly Leu Val Val Gly Glu Cys Cys Pro Thr Pro Ser 
                85                  90                  95      


His Trp Ser Ala Asn Cys Thr Leu His Glu Trp Leu Gln Gln Arg Gly 
            100                 105                 110         


Ile Pro Gly Leu Gln Gly Val Asp Thr Arg Glu Leu Thr Lys Lys Leu 
        115                 120                 125             


Arg Glu Gln Gly Ser Leu Leu Gly Lys Leu Val Gln Lys Gly Thr Glu 
    130                 135                 140                 


Pro Ser Ala Leu Pro Phe Val Asp Pro Asn Ala Arg Pro Leu Ala Pro 
145                 150                 155                 160 


Glu Val Ser Ile Lys Thr Pro Arg Val Phe Asn Ala Gly Gly Ala Pro 
                165                 170                 175     


Arg Ile Cys Ala Leu Asp Cys Gly Leu Lys Tyr Asn Gln Ile Arg Cys 
            180                 185                 190         


Leu Cys Gln Leu Gly Ala Glu Val Thr Val Val Pro Trp Asp His Glu 
        195                 200                 205             


Leu Asp Ser Gln Lys Tyr Asp Gly Leu Phe Leu Ser Asn Gly Pro Gly 
    210                 215                 220                 


Asp Pro Ala Ser Tyr Pro Gly Val Val Ser Thr Leu Ser Arg Val Leu 
225                 230                 235                 240 


Ser Glu Pro Asn Pro Arg Pro Val Phe Gly Ile Cys Leu Gly His Gln 
                245                 250                 255     


Leu Leu Ala Leu Ala Ile Gly Ala Lys Thr Tyr Lys Met Arg Tyr Gly 
            260                 265                 270         


Asn Arg Gly His Asn Gln Pro Cys Leu Leu Val Gly Thr Gly Arg Cys 
        275                 280                 285             


Phe Leu Thr Ser Gln Asn His Gly Phe Ala Val Asp Ala Asp Ser Leu 
    290                 295                 300                 


Pro Ala Gly Trp Ala Pro Leu Phe Thr Asn Ala Asn Asp Cys Ser Asn 
305                 310                 315                 320 


Glu Gly Ile Val His Asp Ser Leu Pro Phe Phe Ser Val Gln Phe His 
                325                 330                 335     


Pro Glu His Arg Ala Gly Pro Ser Asp Met Glu Leu Leu Phe Asp Val 
            340                 345                 350         


Phe Leu Glu Thr Val Arg Glu Ala Ala Ala Gly Asn Ile Gly Gly Gln 
        355                 360                 365             


Thr Val Arg Glu Arg Leu Ala Gln Arg Leu Cys Pro Pro Glu Leu Pro 
    370                 375                 380                 


Ile Pro Gly Ser Gly Leu Pro Pro Pro Arg Lys Val Leu Ile Leu Gly 
385                 390                 395                 400 


Ser Gly Gly Leu Ser Ile Gly Gln Ala Gly Glu Phe Asp Tyr Ser Gly 
                405                 410                 415     


Ser Gln Ala Ile Lys Ala Leu Lys Glu Glu Asn Ile Gln Thr Leu Leu 
            420                 425                 430         


Ile Asn Pro Asn Ile Ala Thr Val Gln Thr Ser Gln Gly Leu Ala Asp 
        435                 440                 445             


Lys Val Tyr Phe Leu Pro Ile Thr Leu His Tyr Val Thr Gln Val Ile 
    450                 455                 460                 


Arg Asn Glu Arg Pro Asp Gly Val Leu Leu Thr Phe Gly Gly Gln Thr 
465                 470                 475                 480 


Ala Leu Asn Cys Gly Val Glu Leu Thr Lys Ala Gly Val Leu Ala Arg 
                485                 490                 495     


Tyr Gly Val Arg Val Leu Gly Thr Pro Val Glu Thr Ile Glu Leu Thr 
            500                 505                 510         


Glu Asp Arg Arg Ala Phe Ala Ala Arg Met Ala Glu Ile Gly Glu His 
        515                 520                 525             


Val Ala Pro Ser Glu Ala Ala Asn Ser Leu Glu Gln Ala Gln Ala Ala 
    530                 535                 540                 


Ala Glu Arg Leu Gly Tyr Pro Val Leu Val Arg Ala Ala Phe Ala Leu 
545                 550                 555                 560 


Gly Gly Leu Gly Ser Gly Phe Ala Ser Thr Lys Glu Glu Leu Ser Ala 
                565                 570                 575     


Leu Val Ala Pro Ala Phe Ala His Thr Ser Gln Val Leu Ile Asp Lys 
            580                 585                 590         


Ser Leu Lys Gly Trp Lys Glu Ile Glu Tyr Glu Val Val Arg Asp Ala 
        595                 600                 605             


Tyr Gly Asn Cys Val Thr Val Cys Asn Met Glu Asn Leu Asp Pro Leu 
    610                 615                 620                 


Gly Ile His Thr Gly Glu Ser Ile Val Val Ala Pro Ser Gln Thr Leu 
625                 630                 635                 640 


Asn Asp Arg Glu Tyr Gln Leu Leu Arg Arg Thr Ala Ile Lys Val Thr 
                645                 650                 655     


Gln His Leu Gly Ile Val Gly Glu Cys Asn Val Gln Tyr Ala Leu Asn 
            660                 665                 670         


Pro Glu Ser Glu Gln Tyr Tyr Ile Ile Glu Val Asn Ala Arg Leu Ser 
        675                 680                 685             


Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr Gly Tyr Pro Leu Ala Tyr 
    690                 695                 700                 


Val Ala Ala Lys Leu Ala Leu Gly Ile Pro Leu Pro Glu Leu Arg Asn 
705                 710                 715                 720 


Ser Val Thr Gly Gly Thr Ala Ala Phe Glu Pro Ser Leu Asp Tyr Cys 
                725                 730                 735     


Val Val Lys Ile Pro Arg Trp Asp Leu Ser Lys Phe Leu Arg Val Ser 
            740                 745                 750         


Thr Lys Ile Gly Ser Cys Met Lys Ser Val Gly Glu Val Met Gly Ile 
        755                 760                 765             


Gly Arg Ser Phe Glu Glu Ala Phe Gln Lys Ala Leu Arg Met Val Asp 
    770                 775                 780                 


Glu Asn Cys Val Gly Phe Asp His Thr Val Lys Pro Val Ser Asp Met 
785                 790                 795                 800 


Glu Leu Glu Thr Pro Thr Asp Lys Arg Ile Phe Val Val Ala Ala Ala 
                805                 810                 815     


Leu Trp Ala Gly Tyr Ser Val Glu Arg Leu Tyr Glu Leu Thr Arg Ile 
            820                 825                 830         


Asp Cys Trp Phe Leu His Arg Met Lys Arg Ile Val Thr His Ala Gln 
        835                 840                 845             


Leu Leu Glu Gln His Arg Gly Gln Ala Leu Pro Gln Asp Leu Leu His 
    850                 855                 860                 


Gln Ala Lys Cys Leu Gly Phe Ser Asp Lys Gln Ile Ala Leu Ala Val 
865                 870                 875                 880 


Leu Ser Thr Glu Leu Ala Val Arg Lys Leu Arg Gln Glu Leu Gly Ile 
                885                 890                 895     


Cys Pro Ala Val Lys Gln Ile Asp Thr Val Ala Ala Glu Trp Pro Ala 
            900                 905                 910         


Gln Thr Asn Tyr Leu Tyr Leu Thr Tyr Trp Gly Asn Thr His Asp Leu 
        915                 920                 925             


Asp Phe Arg Ala Pro His Val Leu Val Leu Gly Ser Gly Val Tyr Arg 
    930                 935                 940                 


Ile Gly Ser Ser Val Glu Phe Asp Trp Cys Ala Val Gly Cys Ile Gln 
945                 950                 955                 960 


Gln Leu Arg Lys Met Gly Tyr Lys Thr Ile Met Val Asn Tyr Asn Pro 
                965                 970                 975     


Glu Thr Val Ser Thr Asp Tyr Asp Met Cys Asp Arg Leu Tyr Phe Asp 
            980                 985                 990         


Glu Ile Ser Phe Glu Val Val Met  Asp Ile Tyr Glu Leu  Glu Asn Pro 
        995                 1000                 1005             


Glu Gly  Val Ile Leu Ser Met  Gly Gly Gln Leu Pro  Asn Asn Met 
    1010                 1015                 1020             


Ala Met  Ala Leu His Arg Gln  Gln Cys Arg Val Leu  Gly Thr Ser 
    1025                 1030                 1035             


Pro Glu  Ala Ile Asp Ser Ala  Glu Asn Arg Phe Lys  Phe Ser Arg 
    1040                 1045                 1050             


Leu Leu  Asp Thr Ile Gly Ile  Ser Gln Pro Gln Trp  Arg Glu Leu 
    1055                 1060                 1065             


Ser Asp  Leu Glu Ser Ala Arg  Gln Phe Cys His Thr  Val Gly Tyr 
    1070                 1075                 1080             


Pro Cys  Val Val Arg Pro Ser  Tyr Val Leu Ser Gly  Ala Ala Met 
    1085                 1090                 1095             


Asn Val  Ala Tyr Thr Asp Gly  Asp Leu Glu Arg Phe  Leu Ser Ser 
    1100                 1105                 1110             


Ala Ala  Ala Val Ser Lys Glu  His Pro Val Val Ile  Ser Lys Phe 
    1115                 1120                 1125             


Ile Gln  Glu Ala Lys Glu Ile  Asp Val Asp Ala Val  Ala Cys Asp 
    1130                 1135                 1140             


Gly Ile  Val Ser Ala Ile Ala  Ile Ser Glu His Val  Glu Asn Ala 
    1145                 1150                 1155             


Gly Val  His Ser Gly Asp Ala  Thr Leu Val Thr Pro  Pro Gln Asp 
    1160                 1165                 1170             


Ile Thr  Pro Lys Thr Leu Glu  Arg Ile Lys Ala Ile  Val His Ala 
    1175                 1180                 1185             


Val Gly  Gln Glu Leu Gln Val  Thr Gly Pro Phe Asn  Leu Gln Leu 
    1190                 1195                 1200             


Ile Ala  Lys Asp Asp Gln Leu  Lys Val Ile Glu Cys  Asn Val Arg 
    1205                 1210                 1215             


Val Ser  Arg Ser Phe Pro Phe  Val Ser Lys Thr Leu  Gly Val Asp 
    1220                 1225                 1230             


Leu Val  Ala Leu Ala Thr Arg  Ile Ile Met Gly Glu  Lys Val Glu 
    1235                 1240                 1245             


Pro Val  Gly Leu Met Thr Gly  Ser Gly Val Val Gly  Val Lys Val 
    1250                 1255                 1260             


Pro Gln  Phe Ser Phe Ser Arg  Leu Ala Gly Ala Asp  Val Val Leu 
    1265                 1270                 1275             


Gly Val  Glu Met Thr Ser Thr  Gly Glu Val Ala Gly  Phe Gly Glu 
    1280                 1285                 1290             


Ser Arg  Cys Glu Ala Tyr Leu  Lys Ala Met Leu Ser  Thr Gly Phe 
    1295                 1300                 1305             


Lys Ile  Pro Glu Lys Asn Ile  Leu Leu Thr Ile Gly  Ser Tyr Lys 
    1310                 1315                 1320             


Asn Lys  Ser Glu Leu Leu Pro  Thr Val Arg Leu Leu  Glu Ser Leu 
    1325                 1330                 1335             


Gly Tyr  Ser Leu Tyr Ala Ser  Leu Gly Thr Ala Asp  Phe Tyr Thr 
    1340                 1345                 1350             


Glu His  Gly Val Lys Val Thr  Ala Val Asp Trp His  Phe Glu Glu 
    1355                 1360                 1365             


Ala Val  Asp Gly Glu Cys Pro  Pro Gln Arg Ser Ile  Leu Asp Gln 
    1370                 1375                 1380             


Leu Ala  Glu Asn His Phe Glu  Leu Val Ile Asn Leu  Ser Met Arg 
    1385                 1390                 1395             


Gly Ala  Gly Gly Arg Arg Leu  Ser Ser Phe Val Thr  Lys Gly Tyr 
    1400                 1405                 1410             


Arg Thr  Arg Arg Leu Ala Ala  Asp Phe Ser Val Pro  Leu Ile Ile 
    1415                 1420                 1425             


Asp Ile  Lys Cys Thr Lys Leu  Phe Val Glu Ala Leu  Gly Gln Ile 
    1430                 1435                 1440             


Gly Pro  Ala Pro Pro Leu Lys  Val His Val Asp Cys  Met Thr Ser 
    1445                 1450                 1455             


Gln Lys  Leu Val Arg Leu Pro  Gly Leu Ile Asp Val  His Val His 
    1460                 1465                 1470             


Leu Arg  Glu Pro Gly Gly Thr  His Lys Glu Asp Phe  Ala Ser Gly 
    1475                 1480                 1485             


Thr Ala  Ala Ala Leu Ala Gly  Gly Val Thr Met Val  Cys Ala Met 
    1490                 1495                 1500             


Pro Asn  Thr Arg Pro Pro Ile  Ile Asp Ala Pro Ala  Leu Ala Leu 
    1505                 1510                 1515             


Ala Gln  Lys Leu Ala Glu Ala  Gly Ala Arg Cys Asp  Phe Thr Leu 
    1520                 1525                 1530             


Phe Leu  Gly Ala Ser Ser Glu  Asn Ala Gly Thr Leu  Gly Ala Val 
    1535                 1540                 1545             


Ala Gly  Ser Ala Ala Gly Leu  Lys Leu Tyr Leu Asn  Glu Thr Phe 
    1550                 1555                 1560             


Ser Glu  Leu Arg Leu Asp Ser  Val Ala Gln Trp Met  Glu His Phe 
    1565                 1570                 1575             


Glu Thr  Trp Pro Ala His Leu  Pro Ile Val Ala His  Ala Glu Arg 
    1580                 1585                 1590             


Gln Ser  Val Ala Ala Val Leu  Met Val Ala Gln Leu  Thr Gln Arg 
    1595                 1600                 1605             


Pro Val  His Ile Cys His Val  Ala Arg Lys Glu Glu  Ile Leu Leu 
    1610                 1615                 1620             


Ile Lys  Thr Ala Lys Ala Gln  Gly Leu Pro Val Thr  Cys Glu Val 
    1625                 1630                 1635             


Ala Pro  His His Leu Phe Leu  Asn Arg Glu Asp Leu  Glu Arg Leu 
    1640                 1645                 1650             


Gly Pro  Gly Lys Gly Glu Val  Arg Pro Glu Leu Gly  Ser Arg Glu 
    1655                 1660                 1665             


Asp Met  Glu Ala Leu Trp Glu  Asn Met Ala Val Ile  Asp Cys Phe 
    1670                 1675                 1680             


Ala Ser  Asp His Ala Pro His  Thr Leu Glu Glu Lys  Cys Gly Pro 
    1685                 1690                 1695             


Lys Pro  Pro Pro Gly Phe Pro  Gly Leu Glu Thr Met  Leu Pro Leu 
    1700                 1705                 1710             


Leu Leu  Thr Ala Val Ser Glu  Gly Arg Leu Ser Leu  Asp Asp Leu 
    1715                 1720                 1725             


Leu Gln  Arg Leu His His Asn  Pro Arg Arg Ile Phe  His Leu Pro 
    1730                 1735                 1740             


Leu Gln  Glu Asp Thr Tyr Val  Glu Val Asp Leu Glu  His Glu Trp 
    1745                 1750                 1755             


Thr Val  Pro Ser His Met Pro  Phe Ser Lys Ala Arg  Trp Thr Pro 
    1760                 1765                 1770             


Phe Glu  Gly Gln Lys Val Lys  Gly Thr Val Arg Arg  Val Val Leu 
    1775                 1780                 1785             


Arg Gly  Glu Val Ala Tyr Ile  Asp Gly Gln Val Leu  Val Pro Pro 
    1790                 1795                 1800             


Gly Tyr  Gly Gln Asp Val Arg  Lys Trp Pro Gln Gly  Val Val Pro 
    1805                 1810                 1815             


Gln Pro  Pro Pro Ser Thr Pro  Ala Thr Thr Glu Ile  Thr Thr Thr 
    1820                 1825                 1830             


Pro Glu  Arg Pro Arg Arg Val  Ile Pro Gly Leu Pro  Asp Gly Arg 
    1835                 1840                 1845             


Phe His  Leu Pro Pro Arg Ile  His Arg Ala Ser Asp  Pro Gly Leu 
    1850                 1855                 1860             


Pro Ala  Glu Glu Pro Lys Glu  Lys Pro Pro Arg Lys  Val Val Glu 
    1865                 1870                 1875             


Pro Glu  Leu Met Gly Thr Pro  Asp Gly Pro Cys Tyr  Pro Ala Pro 
    1880                 1885                 1890             


Pro Val  Pro Arg Gln Ala Ser  Pro Gln Asn Leu Gly  Ser Ser Gly 
    1895                 1900                 1905             


Leu Leu  His Pro Gln Met Ser  Pro Leu Leu His Ser  Leu Val Gly 
    1910                 1915                 1920             


Gln His  Ile Leu Ser Val Lys  Gln Phe Thr Lys Asp  Gln Met Ser 
    1925                 1930                 1935             


His Leu  Phe Asn Val Ala His  Thr Leu Arg Met Met  Val Gln Lys 
    1940                 1945                 1950             


Glu Arg  Ser Leu Asp Ile Leu  Lys Gly Lys Val Met  Ala Ser Met 
    1955                 1960                 1965             


Phe Tyr  Glu Val Ser Thr Arg  Thr Ser Ser Ser Phe  Ala Ala Ala 
    1970                 1975                 1980             


Met Ala  Arg Leu Gly Gly Ala  Val Leu Ser Phe Ser  Glu Ala Thr 
    1985                 1990                 1995             


Ser Ser  Val Gln Lys Gly Glu  Ser Leu Ala Asp Ser  Val Gln Thr 
    2000                 2005                 2010             


Met Ser  Cys Tyr Ala Asp Val  Ile Val Leu Arg His  Pro Gln Pro 
    2015                 2020                 2025             


Gly Ala  Val Glu Leu Ala Ala  Lys His Cys Arg Arg  Pro Val Ile 
    2030                 2035                 2040             


Asn Ala  Gly Asp Gly Val Gly  Glu His Pro Thr Gln  Ala Leu Leu 
    2045                 2050                 2055             


Asp Ile  Phe Thr Ile Arg Glu  Glu Leu Gly Thr Val  Asn Gly Met 
    2060                 2065                 2070             


Thr Ile  Thr Met Val Gly Asp  Leu Lys His Gly Arg  Thr Val His 
    2075                 2080                 2085             


Ser Leu  Ala Cys Leu Leu Thr  Gln Tyr Arg Val Ser  Leu Arg Tyr 
    2090                 2095                 2100             


Val Ala  Pro Pro Ser Leu Arg  Met Pro Pro Ser Val  Arg Asp Phe 
    2105                 2110                 2115             


Val Ala  Ser Arg Gly Thr Lys  Gln Glu Glu Phe Glu  Ser Ile Glu 
    2120                 2125                 2130             


Glu Ala  Leu Pro Asp Thr Asp  Val Leu Tyr Met Thr  Arg Ile Gln 
    2135                 2140                 2145             


Lys Glu  Arg Phe Gly Ser Val  Gln Glu Tyr Glu Ala  Cys Phe Gly 
    2150                 2155                 2160             


Gln Phe  Ile Leu Thr Pro His  Ile Met Thr Arg Ala  Lys Lys Lys 
    2165                 2170                 2175             


Met Val  Val Met His Pro Met  Pro Arg Val Asn Glu  Ile Ser Val 
    2180                 2185                 2190             


Glu Val  Asp Ser Asp Pro Arg  Ala Ala Tyr Phe Arg  Gln Ala Glu 
    2195                 2200                 2205             


Asn Gly  Met Tyr Ile Arg Met  Ala Leu Leu Ala Thr  Val Leu Gly 
    2210                 2215                 2220             


Arg Phe  
    2225 


<210>  9
<211>  535
<212>  PRT
<213>  Mus musculus

<400>  9

Met Ala Ser Leu Ser Leu Ala Pro Val Asn Ile Phe Lys Ala Gly Ala 
1               5                   10                  15      


Asp Glu Glu Arg Ala Glu Thr Ala Arg Leu Ser Ser Phe Ile Gly Ala 
            20                  25                  30          


Ile Ala Ile Gly Asp Leu Val Lys Ser Thr Leu Gly Pro Lys Gly Met 
        35                  40                  45              


Asp Lys Ile Leu Leu Ser Ser Gly Arg Asp Ala Ala Leu Met Val Thr 
    50                  55                  60                  


Asn Asp Gly Ala Thr Ile Leu Lys Asn Ile Gly Val Asp Asn Pro Ala 
65                  70                  75                  80  


Ala Lys Val Leu Val Asp Met Ser Arg Val Gln Asp Asp Glu Val Gly 
                85                  90                  95      


Asp Gly Thr Thr Ser Val Thr Val Leu Ala Ala Glu Leu Leu Arg Glu 
            100                 105                 110         


Ala Glu Ser Leu Ile Ala Lys Lys Ile His Pro Gln Thr Ile Ile Ser 
        115                 120                 125             


Gly Trp Arg Glu Ala Thr Lys Ala Ala Arg Glu Ala Leu Leu Ser Ser 
    130                 135                 140                 


Ala Val Asp His Gly Ser Asp Glu Ala Arg Phe Trp Gln Asp Leu Met 
145                 150                 155                 160 


Asn Ile Ala Gly Thr Thr Leu Ser Ser Lys Leu Leu Thr His His Lys 
                165                 170                 175     


Asp His Phe Thr Lys Leu Ala Val Glu Ala Val Leu Arg Leu Lys Gly 
            180                 185                 190         


Ser Gly Asn Leu Glu Ala Ile His Val Ile Lys Lys Leu Gly Gly Ser 
        195                 200                 205             


Leu Ala Asp Ser Tyr Leu Asp Glu Gly Phe Leu Leu Asp Lys Lys Ile 
    210                 215                 220                 


Gly Val Asn Gln Pro Lys Arg Ile Glu Asn Ala Lys Ile Leu Ile Ala 
225                 230                 235                 240 


Asn Thr Gly Met Asp Thr Asp Lys Ile Lys Ile Phe Gly Ser Arg Val 
                245                 250                 255     


Arg Val Asp Ser Thr Ala Lys Val Ala Glu Ile Glu His Ala Glu Lys 
            260                 265                 270         


Glu Lys Met Lys Glu Lys Val Glu Arg Ile Leu Lys His Gly Ile Asn 
        275                 280                 285             


Cys Phe Ile Asn Arg Gln Leu Ile Tyr Asn Tyr Pro Glu Gln Leu Phe 
    290                 295                 300                 


Gly Ala Ala Gly Val Met Ala Ile Glu His Ala Asp Phe Ala Gly Val 
305                 310                 315                 320 


Glu Arg Leu Ala Leu Val Thr Gly Gly Glu Ile Ala Ser Thr Phe Asp 
                325                 330                 335     


His Pro Glu Leu Val Lys Leu Gly Ser Cys Lys Leu Ile Glu Glu Val 
            340                 345                 350         


Met Ile Gly Glu Asp Lys Leu Ile His Phe Ser Gly Val Ala Leu Gly 
        355                 360                 365             


Glu Ala Cys Thr Ile Val Leu Arg Gly Ala Thr Gln Gln Ile Leu Asp 
    370                 375                 380                 


Glu Ala Glu Arg Ser Leu His Asp Ala Leu Cys Val Leu Ala Gln Thr 
385                 390                 395                 400 


Val Lys Asp Pro Arg Thr Val Tyr Gly Gly Gly Cys Ser Glu Met Leu 
                405                 410                 415     


Met Ala His Ala Val Thr Gln Leu Ala Asn Arg Thr Pro Gly Lys Glu 
            420                 425                 430         


Ala Val Ala Met Glu Ser Phe Ala Lys Ala Leu Arg Met Leu Pro Thr 
        435                 440                 445             


Ile Ile Ala Asp Asn Ala Gly Tyr Asp Ser Ala Asp Leu Val Ala Gln 
    450                 455                 460                 


Leu Arg Ala Ala His Ser Glu Gly His Ile Thr Ala Gly Leu Asp Met 
465                 470                 475                 480 


Lys Glu Gly Thr Ile Gly Asp Met Ala Val Leu Gly Ile Thr Glu Ser 
                485                 490                 495     


Phe Gln Val Lys Arg Gln Val Leu Leu Ser Ala Ala Glu Ala Ala Glu 
            500                 505                 510         


Val Ile Leu Arg Val Asp Asn Ile Ile Lys Ala Ala Pro Arg Lys Arg 
        515                 520                 525             


Val Pro Asp His His Pro Cys 
    530                 535 


<210>  10
<211>  545
<212>  PRT
<213>  Mus musculus

<400>  10

Met Met Gly His Arg Pro Val Leu Val Leu Ser Gln Asn Thr Lys Arg 
1               5                   10                  15      


Glu Ser Gly Arg Lys Val Gln Ser Gly Asn Ile Asn Ala Ala Lys Thr 
            20                  25                  30          


Ile Ala Asp Ile Ile Arg Thr Cys Leu Gly Pro Lys Ser Met Met Lys 
        35                  40                  45              


Met Leu Leu Asp Pro Met Gly Gly Ile Val Met Thr Asn Asp Gly Asn 
    50                  55                  60                  


Ala Ile Leu Arg Glu Ile Gln Val Gln His Pro Ala Ala Lys Ser Met 
65                  70                  75                  80  


Ile Glu Ile Ser Arg Thr Gln Asp Glu Glu Val Gly Asp Gly Thr Thr 
                85                  90                  95      


Ser Val Ile Ile Leu Ala Gly Glu Met Leu Ser Val Ala Glu His Phe 
            100                 105                 110         


Leu Glu Gln Gln Met His Pro Thr Val Val Ile Ser Ala Tyr Arg Met 
        115                 120                 125             


Ala Leu Asp Asp Met Ile Ser Thr Leu Lys Lys Ile Ser Thr Pro Val 
    130                 135                 140                 


Asp Val Asn Asn Arg Glu Met Met Leu Ser Ile Ile Asn Ser Ser Ile 
145                 150                 155                 160 


Thr Thr Lys Val Ile Ser Arg Trp Ser Ser Leu Ala Cys Asn Ile Ala 
                165                 170                 175     


Leu Asp Ala Val Lys Thr Val Gln Phe Glu Glu Asn Gly Arg Lys Glu 
            180                 185                 190         


Ile Asp Ile Lys Lys Tyr Ala Arg Val Glu Lys Ile Pro Gly Gly Ile 
        195                 200                 205             


Ile Glu Asp Ser Cys Val Leu Arg Gly Val Met Ile Asn Lys Asp Val 
    210                 215                 220                 


Thr His Pro Arg Met Arg Arg Tyr Ile Lys Asn Pro Arg Ile Val Leu 
225                 230                 235                 240 


Leu Asp Ser Ser Leu Glu Tyr Lys Lys Gly Glu Ser Gln Thr Asp Ile 
                245                 250                 255     


Glu Ile Thr Arg Glu Glu Asp Phe Thr Arg Ile Leu Gln Met Glu Glu 
            260                 265                 270         


Glu Tyr Ile His Gln Leu Cys Glu Asp Ile Ile Gln Leu Lys Pro Asp 
        275                 280                 285             


Val Val Ile Thr Glu Lys Gly Ile Ser Asp Leu Ala Gln His Tyr Leu 
    290                 295                 300                 


Met Arg Ala Asn Val Thr Ala Ile Arg Arg Val Arg Lys Thr Asp Asn 
305                 310                 315                 320 


Asn Arg Ile Ala Arg Ala Cys Gly Ala Arg Ile Val Ser Arg Pro Glu 
                325                 330                 335     


Glu Leu Arg Glu Asp Asp Val Gly Thr Gly Ala Gly Leu Leu Glu Ile 
            340                 345                 350         


Lys Lys Ile Gly Asp Glu Tyr Phe Thr Phe Ile Thr Asp Cys Lys Asp 
        355                 360                 365             


Pro Lys Ala Cys Thr Ile Leu Leu Arg Gly Ala Ser Lys Glu Ile Leu 
    370                 375                 380                 


Ser Glu Val Glu Arg Asn Leu Gln Asp Ala Met Gln Val Cys Arg Asn 
385                 390                 395                 400 


Val Leu Leu Asp Pro Gln Leu Val Pro Gly Gly Gly Ala Ser Glu Met 
                405                 410                 415     


Ala Val Ala His Ala Leu Thr Glu Lys Ser Lys Ala Met Thr Gly Val 
            420                 425                 430         


Glu Gln Trp Pro Tyr Arg Ala Val Ala Gln Ala Leu Glu Val Ile Pro 
        435                 440                 445             


Arg Thr Leu Ile Gln Asn Cys Gly Ala Ser Thr Ile Arg Leu Leu Thr 
    450                 455                 460                 


Ser Leu Arg Ala Lys His Thr Gln Glu Ser Cys Glu Thr Trp Gly Val 
465                 470                 475                 480 


Asn Gly Glu Thr Gly Thr Leu Val Asp Met Lys Glu Leu Gly Ile Trp 
                485                 490                 495     


Glu Pro Leu Ala Val Lys Leu Gln Thr Tyr Lys Thr Ala Val Glu Thr 
            500                 505                 510         


Ala Val Leu Leu Leu Arg Ile Asp Asp Ile Val Ser Gly His Lys Lys 
        515                 520                 525             


Lys Gly Asp Asp Gln Asn Arg Gln Thr Gly Ala Pro Asp Ala Gly Gln 
    530                 535                 540                 


Glu 
545 


<210>  11
<211>  539
<212>  PRT
<213>  Mus musculus

<400>  11

Met Pro Glu Asn Val Ala Ser Arg Ser Gly Ala Pro Thr Ala Gly Pro 
1               5                   10                  15      


Gly Ser Arg Gly Lys Ser Ala Tyr Gln Asp Arg Asp Lys Pro Ala Gln 
            20                  25                  30          


Ile Arg Phe Ser Asn Ile Ser Ala Ala Lys Ala Val Ala Asp Ala Ile 
        35                  40                  45              


Arg Thr Ser Leu Gly Pro Lys Gly Met Asp Lys Met Ile Gln Asp Gly 
    50                  55                  60                  


Lys Gly Asp Val Thr Ile Thr Asn Asp Gly Ala Thr Ile Leu Lys Gln 
65                  70                  75                  80  


Met Gln Val Leu His Pro Ala Ala Arg Met Leu Val Glu Leu Ser Lys 
                85                  90                  95      


Ala Gln Asp Ile Glu Ala Gly Asp Gly Thr Thr Ser Val Val Ile Ile 
            100                 105                 110         


Ala Gly Ser Leu Leu Asp Ser Cys Thr Lys Leu Leu Gln Lys Gly Ile 
        115                 120                 125             


His Pro Thr Ile Ile Ser Glu Ser Phe Gln Lys Ala Leu Glu Lys Gly 
    130                 135                 140                 


Leu Glu Ile Leu Thr Asp Met Ser Arg Pro Val Gln Leu Ser Asp Arg 
145                 150                 155                 160 


Glu Thr Leu Leu Asn Ser Ala Thr Thr Ser Leu Asn Ser Lys Val Val 
                165                 170                 175     


Ser Gln Tyr Ser Ser Leu Leu Ser Pro Met Ser Val Asn Ala Val Met 
            180                 185                 190         


Lys Val Ile Asp Pro Ala Thr Ala Thr Ser Val Asp Leu Arg Asp Ile 
        195                 200                 205             


Lys Ile Val Lys Lys Leu Gly Gly Thr Ile Asp Asp Cys Glu Leu Val 
    210                 215                 220                 


Glu Gly Leu Val Leu Thr Gln Lys Val Ala Asn Ser Gly Ile Thr Arg 
225                 230                 235                 240 


Val Glu Lys Ala Lys Ile Gly Leu Ile Gln Phe Cys Leu Ser Ala Pro 
                245                 250                 255     


Lys Thr Asp Met Asp Asn Gln Ile Val Val Ser Asp Tyr Ala Gln Met 
            260                 265                 270         


Asp Arg Val Leu Arg Glu Glu Arg Ala Tyr Ile Leu Asn Leu Val Lys 
        275                 280                 285             


Gln Ile Lys Lys Thr Gly Cys Asn Val Leu Leu Ile Gln Lys Ser Ile 
    290                 295                 300                 


Leu Arg Asp Ala Leu Ser Asp Leu Ala Leu His Phe Leu Asn Lys Met 
305                 310                 315                 320 


Lys Ile Met Val Val Lys Asp Val Glu Arg Glu Asp Ile Glu Phe Ile 
                325                 330                 335     


Cys Lys Thr Ile Gly Thr Lys Pro Val Ala His Ile Asp Gln Phe Thr 
            340                 345                 350         


Ala Asp Met Leu Gly Ser Ala Glu Leu Ala Glu Glu Val Ser Leu Asn 
        355                 360                 365             


Gly Ser Gly Lys Leu Phe Lys Ile Thr Gly Cys Thr Ser Pro Gly Lys 
    370                 375                 380                 


Thr Val Thr Ile Val Val Arg Gly Ser Asn Lys Leu Val Ile Glu Glu 
385                 390                 395                 400 


Ala Glu Arg Ser Ile His Asp Ala Leu Cys Val Ile Arg Cys Leu Val 
                405                 410                 415     


Lys Lys Arg Ala Leu Ile Ala Gly Gly Gly Ala Pro Glu Ile Glu Leu 
            420                 425                 430         


Ala Leu Arg Leu Thr Glu Tyr Ser Arg Thr Leu Ser Gly Met Glu Ser 
        435                 440                 445             


Tyr Cys Val Arg Ala Phe Ala Asp Ala Met Glu Val Ile Pro Ser Thr 
    450                 455                 460                 


Leu Ala Glu Asn Ala Gly Leu Asn Pro Ile Ser Thr Val Thr Glu Leu 
465                 470                 475                 480 


Arg Asn Arg His Ala Gln Gly Glu Lys Thr Thr Gly Ile Asn Val Arg 
                485                 490                 495     


Lys Gly Gly Ile Ser Asn Ile Leu Glu Glu Met Val Val Gln Pro Leu 
            500                 505                 510         


Leu Val Ser Val Ser Ala Leu Thr Leu Ala Thr Glu Thr Val Arg Ser 
        515                 520                 525             


Ile Leu Lys Ile Asp Asp Val Val Asn Thr Arg 
    530                 535                 


<210>  12
<211>  541
<212>  PRT
<213>  Mus musculus

<400>  12

Met Ala Ser Val Gly Thr Leu Ala Phe Asp Glu Tyr Gly Arg Pro Phe 
1               5                   10                  15      


Leu Ile Ile Lys Asp Gln Asp Arg Lys Ser Arg Leu Met Gly Leu Glu 
            20                  25                  30          


Ala Leu Lys Ser His Ile Met Ala Ala Lys Ala Val Ala Asn Thr Met 
        35                  40                  45              


Arg Thr Ser Leu Gly Pro Asn Gly Leu Asp Lys Met Met Val Asp Lys 
    50                  55                  60                  


Asp Gly Asp Val Thr Ile Thr Asn Asp Gly Ala Thr Ile Leu Ser Met 
65                  70                  75                  80  


Met Asp Val Asp His Gln Ile Ala Lys Leu Met Val Glu Leu Ser Lys 
                85                  90                  95      


Ser Gln Asp Asp Glu Ile Gly Asp Gly Thr Thr Gly Val Val Val Leu 
            100                 105                 110         


Ala Gly Ala Leu Leu Glu Glu Ala Glu Gln Leu Leu Asp Arg Gly Ile 
        115                 120                 125             


His Pro Ile Arg Ile Ala Asp Gly Tyr Glu Gln Ala Ala Arg Ile Ala 
    130                 135                 140                 


Ile Gln His Leu Asp Lys Ile Ser Asp Lys Val Leu Val Asp Ile Asn 
145                 150                 155                 160 


Asn Pro Glu Pro Leu Ile Gln Thr Ala Lys Thr Thr Leu Gly Ser Lys 
                165                 170                 175     


Val Ile Asn Ser Cys His Arg Gln Met Ala Glu Ile Ala Val Asn Ala 
            180                 185                 190         


Val Leu Thr Val Ala Asp Met Glu Arg Arg Asp Val Asp Phe Glu Leu 
        195                 200                 205             


Ile Lys Val Glu Gly Lys Val Gly Gly Arg Leu Glu Asp Thr Lys Leu 
    210                 215                 220                 


Ile Lys Gly Val Ile Val Asp Lys Asp Phe Ser His Pro Gln Met Pro 
225                 230                 235                 240 


Lys Lys Val Val Asp Ala Lys Ile Ala Ile Leu Thr Cys Pro Phe Glu 
                245                 250                 255     


Pro Pro Lys Pro Lys Thr Lys His Lys Leu Asp Val Met Ser Val Glu 
            260                 265                 270         


Asp Tyr Lys Ala Leu Gln Lys Tyr Glu Lys Glu Lys Phe Glu Glu Met 
        275                 280                 285             


Ile Lys Gln Ile Lys Glu Thr Gly Ala Asn Leu Ala Ile Cys Gln Trp 
    290                 295                 300                 


Gly Phe Asp Asp Glu Ala Asn His Leu Leu Leu Gln Asn Gly Leu Pro 
305                 310                 315                 320 


Ala Val Arg Trp Val Gly Gly Pro Glu Ile Glu Leu Ile Ala Ile Ala 
                325                 330                 335     


Thr Gly Gly Arg Ile Val Pro Arg Phe Ser Glu Leu Thr Ser Glu Lys 
            340                 345                 350         


Leu Gly Phe Ala Gly Val Val Gln Glu Ile Ser Phe Gly Thr Thr Lys 
        355                 360                 365             


Asp Lys Met Leu Val Ile Glu Lys Cys Lys Asn Ser Arg Ala Val Thr 
    370                 375                 380                 


Ile Phe Ile Arg Gly Gly Asn Lys Met Ile Ile Glu Glu Ala Lys Arg 
385                 390                 395                 400 


Ser Leu His Asp Ala Leu Cys Val Ile Arg Asn Leu Ile Arg Asp Asn 
                405                 410                 415     


Arg Val Val Tyr Gly Gly Gly Ala Ala Glu Ile Ser Cys Ala Leu Ala 
            420                 425                 430         


Val Ser Gln Glu Ala Asp Lys Cys Pro Thr Leu Glu Gln Tyr Ala Met 
        435                 440                 445             


Arg Ala Phe Ala Asp Ala Leu Glu Val Ile Pro Met Ala Leu Ser Glu 
    450                 455                 460                 


Asn Ser Gly Met Asn Pro Ile Gln Thr Met Thr Glu Val Arg Ala Arg 
465                 470                 475                 480 


Gln Val Lys Glu Ser Asn Pro Ala Leu Gly Ile Asp Cys Leu His Lys 
                485                 490                 495     


Gly Ser Asn Asp Met Gln Tyr Gln His Val Ile Glu Thr Leu Ile Gly 
            500                 505                 510         


Lys Lys Gln Gln Ile Ser Leu Ala Thr Gln Met Val Arg Met Ile Leu 
        515                 520                 525             


Lys Ile Asp Asp Ile Arg Lys Pro Gly Glu Ser Glu Glu 
    530                 535                 540     


<210>  13
<211>  531
<212>  PRT
<213>  Mus musculus

<400>  13

Met Ala Ala Val Lys Thr Leu Asn Pro Lys Ala Glu Val Ala Arg Ala 
1               5                   10                  15      


Gln Ala Ala Leu Ala Val Asn Ile Ser Ala Ala Arg Gly Leu Gln Asp 
            20                  25                  30          


Val Leu Arg Thr Asn Leu Gly Pro Lys Gly Thr Met Lys Met Leu Val 
        35                  40                  45              


Ser Gly Ala Gly Asp Ile Lys Leu Thr Lys Asp Gly Asn Val Leu Leu 
    50                  55                  60                  


His Glu Met Gln Ile Gln His Pro Thr Ala Ser Leu Ile Ala Lys Val 
65                  70                  75                  80  


Ala Thr Ala Gln Asp Asp Ile Thr Gly Asp Gly Thr Thr Ser Asn Val 
                85                  90                  95      


Leu Ile Ile Gly Glu Leu Leu Lys Gln Ala Asp Leu Tyr Ile Ser Glu 
            100                 105                 110         


Gly Leu His Pro Arg Ile Ile Thr Glu Gly Phe Glu Ala Ala Lys Glu 
        115                 120                 125             


Lys Ala Leu Gln Phe Leu Glu Gln Val Lys Val Ser Lys Glu Met Asp 
    130                 135                 140                 


Arg Glu Thr Leu Ile Asp Val Ala Arg Thr Ser Leu Arg Thr Lys Val 
145                 150                 155                 160 


His Ala Glu Leu Ala Asp Val Leu Thr Glu Ala Val Val Asp Ser Ile 
                165                 170                 175     


Leu Ala Ile Arg Lys Lys Asp Glu Pro Ile Asp Leu Phe Met Val Glu 
            180                 185                 190         


Ile Met Glu Met Lys His Lys Ser Glu Thr Asp Thr Ser Leu Ile Arg 
        195                 200                 205             


Gly Leu Val Leu Asp His Gly Ala Arg His Pro Asp Met Lys Lys Arg 
    210                 215                 220                 


Val Glu Asn Ala Tyr Ile Leu Thr Cys Asn Val Ser Leu Glu Tyr Glu 
225                 230                 235                 240 


Lys Thr Glu Val Asn Ser Gly Phe Phe Tyr Lys Ser Ala Glu Glu Arg 
                245                 250                 255     


Glu Lys Leu Val Lys Ala Glu Arg Lys Phe Ile Glu Asp Arg Val Lys 
            260                 265                 270         


Lys Ile Ile Glu Leu Lys Lys Lys Val Cys Gly Asp Ser Asp Lys Gly 
        275                 280                 285             


Phe Val Val Ile Asn Gln Lys Gly Ile Asp Pro Phe Ser Leu Asp Ala 
    290                 295                 300                 


Leu Ala Lys Glu Gly Ile Val Ala Leu Arg Arg Ala Lys Arg Arg Asn 
305                 310                 315                 320 


Met Glu Arg Leu Thr Leu Ala Cys Gly Gly Ile Ala Leu Asn Ser Phe 
                325                 330                 335     


Asp Asp Leu Asn Pro Asp Cys Leu Gly His Ala Gly Leu Val Tyr Glu 
            340                 345                 350         


Tyr Thr Leu Gly Glu Glu Lys Phe Thr Phe Ile Glu Lys Cys Asn Asn 
        355                 360                 365             


Pro Arg Ser Val Thr Leu Leu Val Lys Gly Pro Asn Lys His Thr Leu 
    370                 375                 380                 


Thr Gln Ile Lys Asp Ala Ile Arg Asp Gly Leu Arg Ala Val Lys Asn 
385                 390                 395                 400 


Ala Ile Asp Asp Gly Cys Val Val Pro Gly Ala Gly Ala Val Glu Val 
                405                 410                 415     


Ala Leu Ala Glu Ala Leu Ile Lys Tyr Lys Pro Ser Val Lys Gly Arg 
            420                 425                 430         


Ala Gln Leu Gly Val Gln Ala Phe Ala Asp Ala Leu Leu Ile Ile Pro 
        435                 440                 445             


Lys Val Leu Ala Gln Asn Ser Gly Phe Asp Leu Gln Glu Thr Leu Val 
    450                 455                 460                 


Lys Val Gln Ala Glu His Ser Glu Ser Gly Gln Leu Val Gly Val Asp 
465                 470                 475                 480 


Leu Ser Thr Gly Glu Pro Met Val Ala Ala Glu Met Gly Val Trp Asp 
                485                 490                 495     


Asn Tyr Cys Val Lys Lys Gln Leu Leu His Ser Cys Thr Val Ile Ala 
            500                 505                 510         


Thr Asn Ile Leu Leu Val Asp Glu Ile Met Arg Ala Gly Met Ser Ser 
        515                 520                 525             


Leu Lys Gly 
    530     


<210>  14
<211>  544
<212>  PRT
<213>  Mus musculus

<400>  14

Met Met Pro Thr Pro Val Ile Leu Leu Lys Glu Gly Thr Asp Ser Ser 
1               5                   10                  15      


Gln Gly Ile Pro Gln Leu Val Ser Asn Ile Ser Ala Cys Gln Val Ile 
            20                  25                  30          


Ala Glu Ala Val Arg Thr Thr Leu Gly Pro Arg Gly Met Asp Lys Leu 
        35                  40                  45              


Ile Val Asp Gly Arg Gly Lys Ala Thr Ile Ser Asn Asp Gly Ala Thr 
    50                  55                  60                  


Ile Leu Lys Leu Leu Asp Val Val His Pro Ala Ala Lys Thr Leu Val 
65                  70                  75                  80  


Asp Ile Ala Lys Ser Gln Asp Ala Glu Val Gly Asp Gly Thr Thr Ser 
                85                  90                  95      


Val Thr Leu Leu Ala Ala Glu Phe Leu Lys Gln Val Lys Pro Tyr Val 
            100                 105                 110         


Glu Glu Gly Leu His Pro Gln Ile Ile Ile Arg Ala Phe Arg Thr Ala 
        115                 120                 125             


Thr Gln Leu Ala Val Asn Lys Ile Lys Glu Ile Ala Val Thr Val Lys 
    130                 135                 140                 


Lys Gln Asp Lys Val Glu Gln Arg Lys Met Leu Glu Lys Cys Ala Met 
145                 150                 155                 160 


Thr Ala Leu Ser Ser Lys Leu Ile Ser Gln Gln Lys Val Phe Phe Ala 
                165                 170                 175     


Lys Met Val Val Asp Ala Val Met Met Leu Asp Glu Leu Leu Gln Leu 
            180                 185                 190         


Lys Met Ile Gly Ile Lys Lys Val Gln Gly Gly Ala Leu Glu Glu Ser 
        195                 200                 205             


Gln Leu Val Ala Gly Val Ala Phe Lys Lys Thr Phe Ser Tyr Ala Gly 
    210                 215                 220                 


Phe Glu Met Gln Pro Lys Lys Tyr Lys Asn Pro Lys Ile Ala Leu Leu 
225                 230                 235                 240 


Asn Val Glu Leu Glu Leu Lys Ala Glu Lys Asp Asn Ala Glu Ile Arg 
                245                 250                 255     


Val His Thr Val Glu Asp Tyr Gln Ala Ile Val Asp Ala Glu Trp Asn 
            260                 265                 270         


Ile Leu Tyr Asp Lys Leu Glu Lys Ile His Gln Ser Gly Ala Lys Val 
        275                 280                 285             


Ile Leu Ser Lys Leu Pro Ile Gly Asp Val Ala Thr Gln Tyr Phe Ala 
    290                 295                 300                 


Asp Arg Asp Met Phe Cys Ala Gly Arg Val Pro Glu Glu Asp Leu Lys 
305                 310                 315                 320 


Arg Thr Met Met Ala Cys Gly Gly Ser Ile Gln Thr Ser Val Asn Ala 
                325                 330                 335     


Leu Val Pro Asp Val Leu Gly His Cys Gln Val Phe Glu Glu Thr Gln 
            340                 345                 350         


Ile Gly Gly Glu Arg Tyr Asn Phe Phe Thr Gly Cys Pro Lys Ala Lys 
        355                 360                 365             


Thr Cys Thr Ile Ile Leu Arg Gly Gly Ala Glu Gln Phe Met Glu Glu 
    370                 375                 380                 


Thr Glu Arg Ser Leu His Asp Ala Ile Met Ile Val Arg Arg Ala Ile 
385                 390                 395                 400 


Lys Asn Asp Ser Val Val Ala Gly Gly Gly Ala Ile Glu Met Glu Leu 
                405                 410                 415     


Ser Lys Tyr Leu Arg Asp Tyr Ser Arg Thr Ile Pro Gly Lys Gln Gln 
            420                 425                 430         


Leu Leu Ile Gly Ala Tyr Ala Lys Ala Leu Glu Ile Ile Pro Arg Gln 
        435                 440                 445             


Leu Cys Asp Asn Ala Gly Phe Asp Ala Thr Asn Ile Leu Asn Lys Leu 
    450                 455                 460                 


Arg Ala Arg His Ala Gln Gly Gly Met Trp Tyr Gly Val Asp Ile Asn 
465                 470                 475                 480 


Asn Glu Asn Ile Ala Asp Asn Phe Gln Ala Phe Val Trp Glu Pro Ala 
                485                 490                 495     


Met Val Arg Ile Asn Ala Leu Thr Ala Ala Ser Glu Ala Ala Cys Leu 
            500                 505                 510         


Ile Val Ser Val Asp Glu Thr Ile Lys Asn Pro Arg Ser Thr Val Asp 
        515                 520                 525             


Pro Pro Ala Pro Ser Ala Gly Arg Gly Arg Gly Gln Ala Arg Phe His 
    530                 535                 540                 


<210>  15
<211>  548
<212>  PRT
<213>  Mus musculus

<400>  15

Met Ala Leu His Val Pro Lys Ala Pro Gly Phe Ala Gln Met Leu Lys 
1               5                   10                  15      


Asp Gly Ala Lys His Phe Ser Gly Leu Glu Glu Ala Val Tyr Arg Asn 
            20                  25                  30          


Ile Gln Ala Cys Lys Glu Leu Ala Gln Thr Thr Arg Thr Ala Tyr Gly 
        35                  40                  45              


Pro Asn Gly Met Asn Lys Met Val Ile Asn Arg Leu Glu Lys Leu Phe 
    50                  55                  60                  


Val Thr Asn Asp Ala Ala Thr Ile Leu Arg Glu Leu Glu Val Gln His 
65                  70                  75                  80  


Pro Ala Ala Lys Met Ile Val Met Ala Ser His Met Gln Glu Gln Glu 
                85                  90                  95      


Val Gly Asp Gly Thr Asn Phe Val Leu Val Phe Ala Gly Ala Leu Leu 
            100                 105                 110         


Glu Leu Ala Glu Glu Leu Leu Arg Ile Gly Leu Ser Val Ser Glu Val 
        115                 120                 125             


Ile Ser Gly Tyr Glu Ile Ala Cys Lys Lys Ala His Glu Ile Leu Pro 
    130                 135                 140                 


Glu Leu Val Cys Cys Ser Ala Lys Asn Leu Arg Asp Val Asp Glu Val 
145                 150                 155                 160 


Ser Ser Leu Leu Arg Thr Ser Ile Met Ser Lys Gln Tyr Gly Ser Glu 
                165                 170                 175     


Thr Phe Leu Ala Lys Leu Ile Ala Gln Ala Cys Val Ser Ile Phe Pro 
            180                 185                 190         


Asp Ser Gly Asn Phe Asn Val Asp Asn Ile Arg Val Cys Lys Ile Leu 
        195                 200                 205             


Gly Ser Gly Ile Tyr Ser Ser Ser Val Leu His Gly Met Val Phe Lys 
    210                 215                 220                 


Lys Glu Thr Glu Gly Asp Val Thr Ser Val Lys Asp Ala Lys Ile Ala 
225                 230                 235                 240 


Val Tyr Ser Cys Pro Phe Asp Gly Met Ile Thr Glu Thr Lys Gly Thr 
                245                 250                 255     


Val Leu Ile Lys Thr Ala Glu Glu Leu Met Asn Phe Ser Lys Gly Glu 
            260                 265                 270         


Glu Asn Leu Met Asp Ala Gln Val Lys Ala Ile Ala Gly Thr Gly Ala 
        275                 280                 285             


Asn Val Ile Val Thr Gly Gly Lys Val Ala Asp Ile Ala Leu His Tyr 
    290                 295                 300                 


Ala Asn Lys Tyr Asn Ile Met Leu Val Arg Leu Asn Ser Lys Trp Asp 
305                 310                 315                 320 


Leu Arg Arg Leu Cys Lys Thr Val Gly Ala Thr Ala Leu Pro Lys Leu 
                325                 330                 335     


Thr Pro Pro Val Gln Glu Glu Met Gly His Cys Asp Ser Val Tyr Leu 
            340                 345                 350         


Ser Glu Val Gly Asp Thr Gln Val Val Val Phe Lys His Glu Lys Glu 
        355                 360                 365             


Asp Gly Ala Ile Ser Thr Ile Val Leu Arg Gly Ser Thr Asp Asn Leu 
    370                 375                 380                 


Met Asp Asp Ile Glu Arg Ala Val Asp Asp Gly Val Asn Thr Phe Lys 
385                 390                 395                 400 


Val Leu Thr Arg Asp Lys Arg Leu Val Pro Gly Gly Gly Ala Thr Glu 
                405                 410                 415     


Ile Glu Leu Ala Lys Gln Ile Thr Ser Tyr Gly Glu Thr Cys Pro Gly 
            420                 425                 430         


Leu Glu Gln Tyr Ala Ile Lys Lys Phe Ala Glu Ala Phe Glu Ala Ile 
        435                 440                 445             


Pro Arg Ala Leu Ala Glu Asn Ser Gly Val Lys Ala Asn Glu Val Ile 
    450                 455                 460                 


Ser Lys Leu Tyr Ser Val His Gln Glu Gly Asn Lys Asn Val Gly Leu 
465                 470                 475                 480 


Asp Ile Glu Ala Glu Val Pro Ala Val Lys Asp Met Leu Glu Ala Ser 
                485                 490                 495     


Ile Leu Asp Thr Tyr Leu Gly Lys Tyr Trp Ala Ile Lys Leu Ala Thr 
            500                 505                 510         


Asn Ala Ala Val Thr Val Leu Arg Val Asp Gln Ile Ile Met Ala Lys 
        515                 520                 525             


Pro Ala Gly Gly Pro Lys Pro Pro Ser Gly Lys Lys Asp Trp Asp Asp 
    530                 535                 540                 


Asp Gln Asn Asp 
545             


<210>  16
<211>  275
<212>  PRT
<213>  Mus musculus

<400>  16

Met Ser Ala Glu Val Lys Val Thr Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Thr Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Leu Ala Glu Ser Asp Phe Ala Ser Thr Phe 
    50                  55                  60                  


Arg Leu Leu Thr Val Phe Ala Tyr Gly Thr Tyr Ala Asp Tyr Leu Ala 
65                  70                  75                  80  


Glu Ala Arg Asn Leu Pro Pro Leu Thr Asp Ala Gln Lys Asn Lys Leu 
                85                  90                  95      


Arg His Leu Ser Val Val Thr Leu Ala Ala Lys Val Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu Arg Asn Val Arg Gln Leu 
        115                 120                 125             


Glu Asp Leu Val Ile Glu Ala Val Tyr Ala Asp Val Leu Arg Gly Ser 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Arg Leu Glu Val Asp Tyr Ser Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Gln Asp Leu Ser Ala Ile Ala Gln Thr Leu Gln Glu 
                165                 170                 175     


Trp Cys Val Gly Cys Glu Val Val Leu Ser Gly Ile Glu Glu Gln Val 
            180                 185                 190         


Ser Arg Ala Asn Gln His Lys Glu Gln Gln Leu Gly Leu Lys Gln Gln 
        195                 200                 205             


Ile Glu Ser Glu Val Ala Asn Leu Lys Lys Thr Ile Lys Val Thr Thr 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Thr Ser Gln Asp Pro Glu Gln His Leu Thr 
225                 230                 235                 240 


Glu Leu Arg Glu Pro Ala Ser Gly Thr Asn Gln Arg Gln Pro Ser Lys 
                245                 250                 255     


Lys Ala Ser Lys Gly Lys Gly Leu Arg Gly Ser Ala Lys Ile Trp Ser 
            260                 265                 270         


Lys Ser Asn 
        275 


<210>  17
<211>  391
<212>  PRT
<213>  Mus musculus

<400>  17

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Thr Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu 
        115                 120                 125             


Thr Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu 
    130                 135                 140                 


Asp Tyr Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His 
145                 150                 155                 160 


Asn Val Met Ile Asp His Glu His Arg Lys Leu Arg Leu Ile Asp Trp 
                165                 170                 175     


Gly Leu Ala Glu Phe Tyr His Pro Gly Gln Glu Tyr Asn Val Arg Val 
            180                 185                 190         


Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln Met 
        195                 200                 205             


Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser 
    210                 215                 220                 


Met Ile Phe Arg Lys Glu Pro Phe Phe His Gly His Asp Asn Tyr Asp 
225                 230                 235                 240 


Gln Leu Val Arg Ile Ala Lys Val Leu Gly Thr Glu Asp Leu Tyr Asp 
                245                 250                 255     


Tyr Ile Asp Lys Tyr Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp Ile 
            260                 265                 270         


Leu Gly Arg His Ser Arg Lys Arg Trp Glu Arg Phe Val His Ser Glu 
        275                 280                 285             


Asn Gln His Leu Val Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys Leu 
    290                 295                 300                 


Leu Arg Tyr Asp His Gln Ser Arg Leu Thr Ala Arg Glu Ala Met Glu 
305                 310                 315                 320 


His Pro Tyr Phe Tyr Thr Val Val Lys Asp Gln Ala Arg Met Ser Ser 
                325                 330                 335     


Thr Ser Met Ala Gly Gly Ser Thr Pro Val Ser Ser Ala Asn Met Met 
            340                 345                 350         


Ser Gly Ile Ser Ser Val Pro Thr Pro Ser Pro Leu Gly Pro Leu Ala 
        355                 360                 365             


Gly Ser Pro Val Ile Ala Ala Ala Asn Ser Leu Gly Ile Pro Val Pro 
    370                 375                 380                 


Ala Ala Ala Gly Ala Gln Gln 
385                 390     


<210>  18
<211>  591
<212>  PRT
<213>  Mus musculus

<400>  18

Met Lys Tyr Ile Leu Val Thr Gly Gly Val Ile Ser Gly Ile Gly Lys 
1               5                   10                  15      


Gly Val Ile Ala Ser Ser Val Gly Thr Ile Leu Lys Ser Cys Gly Leu 
            20                  25                  30          


His Val Thr Ser Ile Lys Ile Asp Pro Tyr Ile Asn Ile Asp Ala Gly 
        35                  40                  45              


Thr Phe Ser Pro Tyr Glu His Gly Glu Val Phe Val Leu Asp Asp Gly 
    50                  55                  60                  


Gly Glu Val Asp Leu Asp Leu Gly Asn Tyr Glu Arg Phe Leu Asp Ile 
65                  70                  75                  80  


Arg Leu Thr Lys Asp Asn Asn Leu Thr Thr Gly Lys Ile Tyr Gln Tyr 
                85                  90                  95      


Val Ile Asn Lys Glu Arg Lys Gly Asp Tyr Leu Gly Lys Thr Val Gln 
            100                 105                 110         


Val Val Pro His Ile Thr Asp Ala Ile Gln Glu Trp Val Met Arg Gln 
        115                 120                 125             


Ala Leu Ile Pro Val Asp Glu Asp Gly Leu Glu Pro Gln Val Cys Val 
    130                 135                 140                 


Ile Glu Leu Gly Gly Thr Val Gly Asp Ile Glu Ser Met Pro Phe Ile 
145                 150                 155                 160 


Glu Ala Phe Arg Gln Phe Gln Phe Lys Val Lys Arg Glu Asn Phe Cys 
                165                 170                 175     


Asn Ile His Val Ser Leu Val Pro Gln Pro Ser Ser Thr Gly Glu Gln 
            180                 185                 190         


Lys Thr Lys Pro Thr Gln Asn Ser Val Arg Glu Leu Arg Gly Leu Gly 
        195                 200                 205             


Leu Ser Pro Asp Leu Val Val Cys Arg Cys Ser Asn Pro Leu Asp Thr 
    210                 215                 220                 


Ser Val Lys Glu Lys Ile Ser Met Phe Cys His Val Glu Pro Glu Gln 
225                 230                 235                 240 


Val Ile Cys Val His Asp Val Ser Ser Ile Tyr Arg Val Pro Leu Leu 
                245                 250                 255     


Leu Glu Glu Gln Gly Val Val Asp Tyr Phe Leu Arg Arg Leu Asp Leu 
            260                 265                 270         


Pro Ile Glu Arg Gln Ser Arg Lys Met Leu Met Lys Trp Lys Glu Met 
        275                 280                 285             


Ala Asp Arg Tyr Asp Arg Leu Leu Glu Thr Cys Ser Ile Ala Leu Val 
    290                 295                 300                 


Gly Lys Tyr Thr Lys Phe Ser Asp Ser Tyr Ala Ser Val Ile Lys Ala 
305                 310                 315                 320 


Leu Glu His Ser Ala Leu Ala Ile Asn His Lys Leu Glu Ile Lys Tyr 
                325                 330                 335     


Ile Asp Ser Thr Asp Leu Glu Pro Ser Thr Leu Gln Glu Glu Pro Val 
            340                 345                 350         


Arg Tyr His Glu Ala Trp Gln Lys Leu Cys Ser Ala His Gly Val Leu 
        355                 360                 365             


Val Pro Gly Gly Phe Gly Val Arg Gly Thr Glu Gly Lys Ile Gln Ala 
    370                 375                 380                 


Ile Ala Trp Ala Arg Lys Gln Lys Lys Pro Phe Leu Gly Val Cys Leu 
385                 390                 395                 400 


Gly Met Gln Leu Ala Val Val Glu Phe Ser Arg Asn Val Leu Gly Trp 
                405                 410                 415     


Gln Asp Ala Asn Ser Thr Glu Phe Asp Pro Lys Thr Ser His Pro Val 
            420                 425                 430         


Val Ile Asp Met Pro Glu His Asn Pro Gly Gln Met Gly Gly Thr Met 
        435                 440                 445             


Arg Leu Gly Lys Arg Arg Thr Leu Phe Gln Thr Lys Asn Ser Val Met 
    450                 455                 460                 


Arg Lys Leu Tyr Gly Asp Thr Asp Tyr Leu Glu Glu Arg His Arg His 
465                 470                 475                 480 


Arg Phe Glu Val Asn Pro Val Leu Lys Lys Cys Leu Glu Glu Gln Gly 
                485                 490                 495     


Leu Lys Phe Val Gly Gln Asp Val Glu Gly Glu Arg Met Glu Ile Val 
            500                 505                 510         


Glu Leu Glu Asp His Pro Phe Phe Val Gly Val Gln Tyr His Pro Glu 
        515                 520                 525             


Phe Leu Ser Arg Pro Ile Lys Pro Ser Pro Pro Tyr Phe Gly Leu Leu 
    530                 535                 540                 


Leu Ala Ser Val Gly Arg Leu Pro His Tyr Leu Gln Lys Gly Cys Arg 
545                 550                 555                 560 


Leu Ser Pro Arg Asp Thr Tyr Ser Asp Arg Ser Gly Ser Ser Ser Pro 
                565                 570                 575     


Asp Ser Glu Ile Thr Glu Leu Lys Phe Pro Ser Ile Ser Gln Asp 
            580                 585                 590     


<210>  19
<211>  776
<212>  PRT
<213>  Mus musculus

<400>  19

Met Ser Ser Asn Arg Ser Gln Asn Pro His Gly Leu Lys Gln Ile Gly 
1               5                   10                  15      


Leu Asp Gln Ile Trp Asp Asp Leu Arg Ala Gly Ile Gln Gln Val Tyr 
            20                  25                  30          


Thr Arg Gln Ser Met Ala Lys Ser Arg Tyr Met Glu Leu Tyr Thr His 
        35                  40                  45              


Val Tyr Asn Tyr Cys Thr Ser Val His Gln Ser Asn Gln Ala Arg Gly 
    50                  55                  60                  


Ala Gly Val Pro Pro Ser Lys Ser Lys Lys Gly Gln Thr Pro Gly Gly 
65                  70                  75                  80  


Ala Gln Phe Val Gly Leu Glu Leu Tyr Lys Arg Leu Lys Glu Phe Leu 
                85                  90                  95      


Lys Asn Tyr Leu Thr Asn Leu Leu Lys Asp Gly Glu Asp Leu Met Asp 
            100                 105                 110         


Glu Ser Val Leu Lys Phe Tyr Thr Gln Gln Trp Glu Asp Tyr Arg Phe 
        115                 120                 125             


Ser Ser Lys Val Leu Asn Gly Ile Cys Ala Tyr Leu Asn Arg His Trp 
    130                 135                 140                 


Val Arg Arg Glu Cys Asp Glu Gly Arg Lys Gly Ile Tyr Glu Ile Tyr 
145                 150                 155                 160 


Ser Leu Ala Leu Val Thr Trp Arg Asp Cys Leu Phe Arg Pro Leu Asn 
                165                 170                 175     


Lys Gln Val Thr Asn Ala Val Leu Lys Leu Ile Glu Lys Glu Arg Asn 
            180                 185                 190         


Gly Glu Thr Ile Asn Thr Arg Leu Ile Ser Gly Val Val Gln Ser Tyr 
        195                 200                 205             


Val Glu Leu Gly Leu Asn Glu Asp Asp Ala Phe Ala Lys Gly Pro Thr 
    210                 215                 220                 


Leu Thr Val Tyr Lys Glu Ser Phe Glu Ser Gln Phe Leu Ala Asp Thr 
225                 230                 235                 240 


Glu Arg Phe Tyr Thr Arg Glu Ser Thr Glu Phe Leu Gln Gln Asn Pro 
                245                 250                 255     


Val Thr Glu Tyr Met Lys Lys Ala Glu Ala Arg Leu Leu Glu Glu Gln 
            260                 265                 270         


Arg Arg Val Gln Val Tyr Leu His Glu Ser Thr Gln Asp Glu Leu Ala 
        275                 280                 285             


Arg Lys Cys Glu Gln Val Leu Ile Glu Lys His Leu Glu Ile Phe His 
    290                 295                 300                 


Thr Glu Phe Gln Asn Leu Leu Asp Ala Asp Lys Asn Glu Asp Leu Gly 
305                 310                 315                 320 


Arg Met Tyr Asn Leu Val Ser Arg Ile Gln Asp Gly Leu Gly Glu Leu 
                325                 330                 335     


Lys Lys Leu Leu Glu Thr His Ile His Asn Gln Gly Leu Ala Ala Ile 
            340                 345                 350         


Glu Lys Cys Gly Glu Ala Ala Leu Asn Asp Pro Lys Met Tyr Val Gln 
        355                 360                 365             


Thr Val Leu Asp Val His Lys Lys Tyr Asn Ala Leu Val Met Ser Ala 
    370                 375                 380                 


Phe Asn Asn Asp Ala Gly Phe Val Ala Ala Leu Asp Lys Ala Cys Gly 
385                 390                 395                 400 


Arg Phe Ile Asn Asn Asn Ala Val Thr Lys Met Ala Gln Ser Ser Ser 
                405                 410                 415     


Lys Ser Pro Glu Leu Leu Ala Arg Tyr Cys Asp Ser Leu Leu Lys Lys 
            420                 425                 430         


Ser Ser Lys Asn Pro Glu Glu Ala Glu Leu Glu Asp Thr Leu Asn Gln 
        435                 440                 445             


Val Met Val Val Phe Lys Tyr Ile Glu Asp Lys Asp Val Phe Gln Lys 
    450                 455                 460                 


Phe Tyr Ala Lys Met Leu Ala Lys Arg Leu Val His Gln Asn Ser Ala 
465                 470                 475                 480 


Ser Asp Asp Ala Glu Ala Ser Met Ile Ser Lys Leu Lys Gln Ala Cys 
                485                 490                 495     


Gly Phe Glu Tyr Thr Ser Lys Leu Gln Arg Met Phe Gln Asp Ile Gly 
            500                 505                 510         


Val Ser Lys Asp Leu Asn Glu Gln Phe Lys Lys His Leu Thr Asn Ser 
        515                 520                 525             


Glu Pro Leu Asp Leu Asp Phe Ser Ile Gln Val Leu Ser Ser Gly Ser 
    530                 535                 540                 


Trp Pro Phe Gln Gln Ser Cys Thr Phe Ala Leu Pro Ser Glu Leu Glu 
545                 550                 555                 560 


Arg Ser Tyr Gln Arg Phe Thr Ala Phe Tyr Ala Ser Arg His Ser Gly 
                565                 570                 575     


Arg Lys Leu Thr Trp Leu Tyr Gln Leu Ser Lys Gly Glu Leu Val Thr 
            580                 585                 590         


Asn Cys Phe Lys Asn Arg Tyr Thr Leu Gln Ala Ser Thr Phe Gln Met 
        595                 600                 605             


Ala Ile Leu Leu Gln Tyr Asn Thr Glu Asp Ala Tyr Thr Val Gln Gln 
    610                 615                 620                 


Leu Thr Asp Ser Thr Gln Ile Lys Met Asp Ile Leu Ala Gln Val Leu 
625                 630                 635                 640 


Gln Ile Leu Leu Lys Ser Lys Leu Leu Val Leu Glu Asp Glu Asn Ala 
                645                 650                 655     


Asn Val Asp Glu Val Glu Leu Lys Pro Asp Thr Leu Ile Lys Leu Tyr 
            660                 665                 670         


Leu Gly Tyr Lys Asn Lys Lys Leu Arg Val Asn Ile Asn Val Pro Met 
        675                 680                 685             


Lys Thr Glu Gln Lys Gln Glu Gln Glu Thr Thr His Lys Asn Ile Glu 
    690                 695                 700                 


Glu Asp Arg Lys Leu Leu Ile Gln Ala Ala Ile Val Arg Ile Met Lys 
705                 710                 715                 720 


Met Arg Lys Val Leu Lys His Gln Gln Leu Leu Gly Glu Val Leu Thr 
                725                 730                 735     


Gln Leu Ser Ser Arg Phe Lys Pro Arg Val Pro Val Ile Lys Lys Cys 
            740                 745                 750         


Ile Asp Ile Leu Ile Glu Lys Glu Tyr Leu Glu Arg Val Asp Gly Glu 
        755                 760                 765             


Lys Asp Thr Tyr Ser Tyr Leu Ala 
    770                 775     


<210>  20
<211>  397
<212>  PRT
<213>  Mus musculus

<400>  20

Met Val Lys Glu Thr Thr Tyr Tyr Asp Val Leu Gly Val Lys Pro Asn 
1               5                   10                  15      


Ala Thr Gln Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys 
            20                  25                  30          


Tyr His Pro Asp Lys Asn Pro Asn Glu Gly Glu Lys Phe Lys Gln Ile 
        35                  40                  45              


Ser Gln Ala Tyr Glu Val Leu Ala Asp Ser Lys Lys Arg Glu Leu Tyr 
    50                  55                  60                  


Asp Lys Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ala Gly Gly Gly 
65                  70                  75                  80  


Phe Gly Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly Gly 
                85                  90                  95      


Arg Met Gln Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu Ser 
            100                 105                 110         


Val Thr Leu Glu Asp Leu Tyr Asn Gly Ala Thr Arg Lys Leu Ala Leu 
        115                 120                 125             


Gln Lys Asn Val Ile Cys Asp Lys Cys Glu Gly Arg Gly Gly Lys Lys 
    130                 135                 140                 


Gly Ala Val Glu Cys Cys Pro Asn Cys Arg Gly Thr Gly Met Gln Ile 
145                 150                 155                 160 


Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Ser Val 
                165                 170                 175     


Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro Lys Asp Arg 
            180                 185                 190         


Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys Lys Ile Leu 
        195                 200                 205             


Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys Ile Thr Phe 
    210                 215                 220                 


His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly Asp Ile Ile 
225                 230                 235                 240 


Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg Arg Gly Glu 
                245                 250                 255     


Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala Leu Cys Gly 
            260                 265                 270         


Phe Gln Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile Val Ile Thr 
        275                 280                 285             


Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys Cys Val Leu 
    290                 295                 300                 


Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys Gly Arg Leu 
305                 310                 315                 320 


Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe Leu Ser Pro 
                325                 330                 335     


Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg Lys Glu Val 
            340                 345                 350         


Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp Phe Asp Pro 
        355                 360                 365             


Asn Gln Glu Arg Arg Arg His Tyr Asn Gly Glu Ala Tyr Glu Asp Asp 
    370                 375                 380                 


Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser 
385                 390                 395         


<210>  21
<211>  494
<212>  PRT
<213>  Mus musculus

<400>  21

Met Ala Ala Thr Ala Glu Cys Asp Val Val Met Ala Ala Thr Glu Pro 
1               5                   10                  15      


Glu Leu Leu Glu Asp Glu Asp Ala Lys Arg Glu Ala Glu Ser Phe Lys 
            20                  25                  30          


Glu Gln Gly Asn Ala Tyr Tyr Ala Lys Lys Asp Tyr Asn Glu Ala Tyr 
        35                  40                  45              


Asn Tyr Tyr Thr Lys Ala Ile Asp Met Cys Pro Asn Asn Ala Ser Tyr 
    50                  55                  60                  


Tyr Gly Asn Arg Ala Ala Thr Leu Met Met Leu Gly Arg Phe Arg Glu 
65                  70                  75                  80  


Ala Leu Gly Asp Ala Gln Gln Ser Val Arg Leu Asp Asp Ser Phe Val 
                85                  90                  95      


Arg Gly His Leu Arg Glu Gly Lys Cys His Leu Ser Leu Gly Asn Ala 
            100                 105                 110         


Met Ala Ala Cys Arg Ser Phe Gln Arg Ala Leu Glu Leu Asp His Lys 
        115                 120                 125             


Asn Ala Gln Ala Gln Gln Glu Phe Lys Asn Ala Asn Ala Val Met Glu 
    130                 135                 140                 


Tyr Glu Lys Ile Ala Glu Val Asp Phe Glu Lys Arg Asp Phe Arg Lys 
145                 150                 155                 160 


Val Val Phe Cys Met Asp Arg Ala Leu Glu Phe Ala Pro Ala Cys His 
                165                 170                 175     


Arg Phe Lys Ile Leu Lys Ala Glu Cys Leu Ala Met Leu Gly Arg Tyr 
            180                 185                 190         


Pro Glu Ala Gln Phe Val Ala Ser Asp Ile Leu Arg Met Asp Ser Thr 
        195                 200                 205             


Asn Ala Asp Ala Leu Tyr Val Arg Gly Leu Cys Leu Tyr Tyr Glu Asp 
    210                 215                 220                 


Cys Ile Glu Lys Ala Val Gln Phe Phe Val Gln Ala Leu Arg Met Ala 
225                 230                 235                 240 


Pro Asp His Glu Lys Ala Cys Val Ala Cys Arg Asn Ala Lys Ala Leu 
                245                 250                 255     


Lys Ala Lys Lys Glu Asp Gly Asn Lys Ala Phe Lys Glu Gly Asn Tyr 
            260                 265                 270         


Lys Leu Ala Tyr Glu Leu Tyr Thr Glu Ala Leu Gly Ile Asp Pro Asn 
        275                 280                 285             


Asn Ile Lys Thr Asn Ala Lys Leu Tyr Cys Asn Arg Gly Thr Val Asn 
    290                 295                 300                 


Ser Lys Leu Arg Gln Leu Glu Asp Ala Ile Glu Asp Cys Thr Asn Ala 
305                 310                 315                 320 


Val Lys Leu Asp Asp Thr Tyr Ile Lys Ala Tyr Leu Arg Arg Ala Gln 
                325                 330                 335     


Cys Tyr Met Asp Thr Glu Gln Phe Glu Glu Ala Val Arg Asp Tyr Glu 
            340                 345                 350         


Lys Val Tyr Gln Thr Glu Lys Thr Lys Glu His Lys Gln Leu Leu Lys 
        355                 360                 365             


Asn Ala Gln Leu Glu Leu Lys Lys Ser Lys Arg Lys Asp Tyr Tyr Lys 
    370                 375                 380                 


Ile Leu Gly Val Asp Lys Asn Ala Ser Glu Asp Glu Ile Lys Lys Ala 
385                 390                 395                 400 


Tyr Arg Lys Arg Ala Leu Met His His Pro Asp Arg His Ser Gly Ala 
                405                 410                 415     


Ser Ala Glu Val Gln Lys Glu Glu Glu Lys Lys Phe Lys Glu Val Gly 
            420                 425                 430         


Glu Ala Phe Thr Ile Leu Ser Asp Pro Lys Lys Lys Thr Arg Tyr Asp 
        435                 440                 445             


Ser Gly Gln Asp Leu Asp Glu Glu Gly Met Asn Met Gly Asp Phe Asp 
    450                 455                 460                 


Ala Asn Asn Ile Phe Lys Ala Phe Phe Gly Gly Pro Gly Gly Phe Ser 
465                 470                 475                 480 


Phe Glu Ala Ser Gly Pro Gly Asn Phe Tyr Phe Gln Phe Gly 
                485                 490                 


<210>  22
<211>  406
<212>  PRT
<213>  Mus musculus

<400>  22

Met Asn Pro Ala Val Phe Leu Ser Leu Ala Asp Leu Arg Cys Ser Leu 
1               5                   10                  15      


Leu Leu Leu Val Thr Ser Ile Phe Thr Pro Ile Thr Ala Glu Ile Ala 
            20                  25                  30          


Ser Leu Asp Ser Glu Asn Ile Asp Glu Ile Leu Asn Asn Ala Asp Val 
        35                  40                  45              


Ala Leu Val Asn Phe Tyr Ala Asp Trp Cys Arg Phe Ser Gln Met Leu 
    50                  55                  60                  


His Pro Ile Phe Glu Glu Ala Ser Asp Val Ile Lys Glu Glu Tyr Pro 
65                  70                  75                  80  


Asp Lys Asn Gln Val Val Phe Ala Arg Val Asp Cys Asp Gln His Ser 
                85                  90                  95      


Asp Ile Ala Gln Arg Tyr Arg Ile Ser Lys Tyr Pro Thr Leu Lys Leu 
            100                 105                 110         


Phe Arg Asn Gly Met Met Met Lys Arg Glu Tyr Arg Gly Gln Arg Ser 
        115                 120                 125             


Val Lys Ala Leu Ala Asp Tyr Ile Arg Gln Gln Lys Ser Asn Pro Val 
    130                 135                 140                 


His Glu Ile Gln Ser Leu Asp Glu Val Thr Asn Leu Asp Arg Ser Lys 
145                 150                 155                 160 


Arg Asn Ile Ile Gly Tyr Phe Glu Gln Lys Asp Ser Glu Asn Tyr Arg 
                165                 170                 175     


Val Phe Glu Arg Val Ala Ser Ile Leu His Asp Asp Cys Ala Phe Leu 
            180                 185                 190         


Ser Ala Phe Gly Asp Leu Ser Lys Pro Glu Arg Tyr Asn Gly Asp Asn 
        195                 200                 205             


Val Ile Tyr Lys Pro Pro Gly Arg Ser Ala Pro Asp Met Val Tyr Leu 
    210                 215                 220                 


Gly Ser Met Thr Asn Phe Asp Val Thr Tyr Asn Trp Ile Gln Asp Lys 
225                 230                 235                 240 


Cys Val Pro Leu Val Arg Glu Ile Thr Phe Glu Asn Gly Glu Glu Leu 
                245                 250                 255     


Thr Glu Glu Gly Leu Pro Phe Leu Ile Leu Phe His Met Lys Asp Asp 
            260                 265                 270         


Thr Glu Ser Leu Glu Ile Phe Gln Asn Glu Val Ala Arg Gln Leu Ile 
        275                 280                 285             


Ser Glu Lys Gly Thr Ile Asn Phe Leu His Ala Asp Cys Asp Lys Phe 
    290                 295                 300                 


Arg His Pro Leu Leu His Ile Gln Lys Thr Pro Ala Asp Cys Pro Val 
305                 310                 315                 320 


Ile Ala Ile Asp Ser Phe Arg His Met Tyr Val Phe Gly Asp Phe Lys 
                325                 330                 335     


Asp Val Leu Ile Pro Gly Lys Leu Lys Gln Phe Val Phe Asp Leu His 
            340                 345                 350         


Ser Gly Lys Leu His Arg Glu Phe His His Gly Pro Asp Pro Thr Asp 
        355                 360                 365             


Thr Ala Pro Gly Glu Gln Asp Gln Asp Val Ala Ser Ser Pro Pro Glu 
    370                 375                 380                 


Ser Ser Phe Gln Lys Leu Ala Pro Ser Glu Tyr Arg Tyr Thr Leu Leu 
385                 390                 395                 400 


Arg Asp Arg Asp Glu Leu 
                405     


<210>  23
<211>  433
<212>  PRT
<213>  Mus musculus

<400>  23

Met Pro Ser Glu Ile Leu Val Lys Ile Leu Ser Tyr Leu Asp Ala Val 
1               5                   10                  15      


Thr Leu Val Cys Ile Gly Cys Val Ser Arg Arg Phe Tyr His Leu Ala 
            20                  25                  30          


Asp Asp Asn Leu Ile Trp Val Arg Lys Tyr Ala Ala Ala Phe Arg Ser 
        35                  40                  45              


Lys Arg Ser Arg Trp Lys Ala Thr Ser Val Glu Glu Thr Ala Thr Ser 
    50                  55                  60                  


Leu Ser Leu Leu Ser Val Trp Asp Lys Glu Asp Gly Tyr Trp Lys Lys 
65                  70                  75                  80  


Glu Tyr Ile Thr Lys Gln Ile Ser Ser Val Arg Ala Ala Leu Thr Asn 
                85                  90                  95      


Ser Leu Ser Pro Val Lys Arg Arg Thr Ser Leu Pro Ser Lys Thr Lys 
            100                 105                 110         


Glu Ser Leu Arg Ile Ser Gly Leu Gly Trp Thr Ile Ile Leu Arg Glu 
        115                 120                 125             


Ala Ser Gly Lys Glu His Ile Met Gln His Ser Asn Leu Ser Val Asn 
    130                 135                 140                 


Asp Asn Ser Val Thr Val Phe Trp His Asp Lys Asn Trp Pro His Val 
145                 150                 155                 160 


Asp Thr Leu Ser Thr Leu Asp Leu Tyr Gly Ala Thr Pro Ile Phe Met 
                165                 170                 175     


Glu Gln Tyr Lys Gly Pro Asn Thr Ser Cys Pro Arg Trp Leu Ser Leu 
            180                 185                 190         


Ile Glu Lys Tyr Asp Leu Ser Asn Leu Arg Lys Ser Ala Met Ile Gly 
        195                 200                 205             


Cys Asp Arg His Val Arg Val Phe Cys Val Asn Pro Gly Leu Leu Val 
    210                 215                 220                 


Gly Leu Trp Gln Glu Asn Gly Gly Leu Ala Phe Val Met Ala Asn Ile 
225                 230                 235                 240 


His Ser His Gly Leu Phe Glu Arg Ser Ile Met Gly Ser Asp Thr Ile 
                245                 250                 255     


Pro Tyr Thr Leu Pro Pro Asp Thr Thr Phe Val Asp Asn Tyr Pro Asp 
            260                 265                 270         


Ser Met Thr Phe Tyr Gly Asp Lys Gly Phe Gln Leu His Ile Asp Ile 
        275                 280                 285             


His Gly Ser Lys Thr Tyr Phe Leu Cys Ser Thr Phe His Asn Leu Phe 
    290                 295                 300                 


Cys Arg Arg Ala Gly Ile Asn Asn Gly Tyr Val Lys Phe Leu Met Ile 
305                 310                 315                 320 


Asn Leu Lys Asn Asn Arg Glu His Leu Pro Leu Val Gly Lys Val Gly 
                325                 330                 335     


Leu Glu Trp Arg Thr Asp Cys Leu Asn Gly Arg Ile Glu Ser Cys Ile 
            340                 345                 350         


Val Val Asp Met Thr Leu Leu Asp Glu Asp Lys Lys Pro Ile Trp Tyr 
        355                 360                 365             


Val Ser Ser Pro Val Cys Leu Arg Ser Ala Cys Leu Pro Asp Phe Pro 
    370                 375                 380                 


Gln Pro Ala Tyr Ser Phe Glu Tyr Met Asp Ser Val Gly Gly Val Cys 
385                 390                 395                 400 


Ala Asp Leu Gly Trp Phe Glu Asn Thr Asp Glu Tyr Phe Ile Val Arg 
                405                 410                 415     


Leu Asp Ile Tyr Leu Ser Val Ala Lys Leu Gln Gln Trp Phe Gly Arg 
            420                 425                 430         


Gln 
    


<210>  24
<211>  480
<212>  PRT
<213>  Mus musculus

<400>  24

Met Ala Ala Val Glu Ala Glu Thr Gly Leu Leu Thr Leu Glu Ser Leu 
1               5                   10                  15      


Pro Thr Asp Pro Leu Leu Leu Ile Leu Ser Phe Val Asp Tyr Arg Asp 
            20                  25                  30          


Leu Ile Asn Cys Cys Tyr Val Ser Arg Arg Leu Ser Gln Leu Ser Thr 
        35                  40                  45              


His Asp Pro Leu Trp Arg Arg His Cys Lys Lys Tyr Trp Leu Ile Ser 
    50                  55                  60                  


Glu Glu Glu Lys Ala Gly Lys Ser Gln Cys Trp Arg Ser Leu Phe Ile 
65                  70                  75                  80  


Glu Thr Tyr Ser Asp Val Gly Arg Tyr Ile Asp His Tyr Ala Ala Ile 
                85                  90                  95      


Lys Lys Ala Trp Arg Asp Leu Lys Lys Tyr Leu Glu Pro Arg Cys Pro 
            100                 105                 110         


Arg Met Val Leu Ser Leu Lys Glu Gly Ala Arg Glu Glu Asp Leu Asp 
        115                 120                 125             


Ala Val Glu Ala Gln Ile Gly Cys Lys Leu Pro Asp Asp Tyr Arg Cys 
    130                 135                 140                 


Ser Tyr Arg Ile His Asn Gly Gln Lys Leu Val Val Pro Gly Leu Leu 
145                 150                 155                 160 


Gly Ser Met Ala Leu Ser Asn His Tyr Arg Ser Glu Asp Leu Leu Asp 
                165                 170                 175     


Val Asp Thr Ala Ala Gly Gly Phe Gln Gln Arg Gln Gly Leu Lys Tyr 
            180                 185                 190         


Cys Leu Pro Leu Thr Phe Cys Ile His Thr Gly Leu Ser Gln Tyr Ile 
        195                 200                 205             


Ala Val Glu Ala Ala Glu Gly Arg Asn Lys Asn Glu Val Phe Tyr Gln 
    210                 215                 220                 


Cys Pro Asp Gln Met Ala Arg Asn Pro Ala Ala Ile Asp Met Phe Ile 
225                 230                 235                 240 


Ile Gly Ala Thr Phe Thr Asp Trp Phe Thr Ser Tyr Val Asn Asn Val 
                245                 250                 255     


Val Ser Gly Gly Phe Pro Ile Ile Arg Asp Gln Ile Phe Arg Tyr Ile 
            260                 265                 270         


His Asp Pro Glu Cys Val Ala Thr Thr Gly Asp Ile Thr Val Ser Val 
        275                 280                 285             


Ser Thr Ser Phe Leu Pro Glu Leu Ser Ser Val His Pro Pro His Tyr 
    290                 295                 300                 


Phe Phe Thr Tyr Arg Ile Arg Ile Glu Met Ser Arg Asp Ala Leu Pro 
305                 310                 315                 320 


Glu Lys Ala Cys Gln Leu Asp Ser Arg Tyr Trp Arg Ile Thr Asn Ala 
                325                 330                 335     


Lys Gly Asp Val Glu Glu Val Gln Gly Pro Gly Val Val Gly Glu Phe 
            340                 345                 350         


Pro Ile Ile Ser Pro Gly Arg Ile Tyr Glu Tyr Thr Ser Cys Thr Thr 
        355                 360                 365             


Phe Ser Thr Thr Ser Gly Tyr Met Glu Gly Tyr Tyr Thr Phe His Phe 
    370                 375                 380                 


Leu Tyr Phe Lys Asp Lys Val Phe Asn Val Ala Ile Pro Arg Phe His 
385                 390                 395                 400 


Met Ala Cys Pro Thr Phe Arg Val Ser Ile Ala Arg Leu Glu Met Gly 
                405                 410                 415     


Pro Asp Glu Tyr Glu Glu Met Glu Glu Glu Ala Glu Glu Glu Glu Glu 
            420                 425                 430         


Glu Glu Asn Asp Asp Ser Ala Asp Met Asp Glu Ser Asp Glu Ser Asp 
        435                 440                 445             


Ala Asp Glu Asn Glu Ser Asp Glu Gly Glu Gly Glu Ala Arg Arg Arg 
    450                 455                 460                 


Arg Val Phe Asp Val Pro Ile Arg Arg Arg Arg Cys Ser Arg Leu Phe 
465                 470                 475                 480 


<210>  25
<211>  274
<212>  PRT
<213>  Mus musculus

<400>  25

Met Gly Thr Asp Ser Arg Ala Ala Gly Ala Leu Leu Ala Arg Ala Ser 
1               5                   10                  15      


Thr Leu His Leu Gln Thr Gly Asn Leu Leu Asn Trp Gly Arg Leu Arg 
            20                  25                  30          


Lys Lys Cys Pro Ser Thr His Ser Glu Glu Leu Arg Asp Cys Ile Gln 
        35                  40                  45              


Lys Thr Leu Asn Glu Trp Ser Ser Gln Ile Ser Pro Asp Leu Val Arg 
    50                  55                  60                  


Glu Phe Pro Asp Val Leu Glu Cys Thr Met Ser His Ala Val Glu Lys 
65                  70                  75                  80  


Ile Asn Pro Asp Glu Arg Glu Glu Met Lys Val Ser Ala Lys Leu Phe 
                85                  90                  95      


Ile Val Gly Ser Asn Ser Ser Ser Ser Thr Arg Ser Ala Val Asp Met 
            100                 105                 110         


Ala Cys Ser Val Leu Gly Val Ala Gln Leu Asp Ser Val Ile Met Ala 
        115                 120                 125             


Ser Pro Pro Ile Glu Asp Gly Val Asn Leu Ser Leu Glu His Leu Gln 
    130                 135                 140                 


Pro Tyr Trp Glu Glu Leu Glu Asn Leu Val Gln Ser Lys Lys Ile Val 
145                 150                 155                 160 


Ala Ile Gly Thr Ser Asp Leu Asp Lys Thr Gln Leu Glu Gln Leu Tyr 
                165                 170                 175     


Gln Trp Ala Gln Val Lys Pro Asn Ser Asn Gln Val Asn Leu Ala Ser 
            180                 185                 190         


Cys Cys Val Met Pro Pro Asp Leu Thr Ala Phe Ala Lys Gln Phe Asp 
        195                 200                 205             


Ile Gln Leu Leu Thr His Asn Asp Pro Lys Glu Leu Leu Ser Glu Ala 
    210                 215                 220                 


Ser Phe Gln Glu Ala Leu Gln Glu Ser Ile Pro Asp Ile Glu Ala Gln 
225                 230                 235                 240 


Asp Trp Val Pro Leu Trp Leu Leu Arg Tyr Ser Val Ile Val Lys Ser 
                245                 250                 255     


Arg Gly Ile Ile Lys Ser Lys Gly Tyr Ile Leu Gln Ala Lys Arg Arg 
            260                 265                 270         


Gly Ser 
        


<210>  26
<211>  1025
<212>  PRT
<213>  Mus musculus

<400>  26

Met Gln Leu Cys Ala Arg Ala Trp Gly Leu Arg Leu Gly Arg Gly Ala 
1               5                   10                  15      


Gly Gly Gly His Arg Leu Ala Arg Gly Thr Gly Leu Ser Trp Ala Gln 
            20                  25                  30          


Arg Ser Arg Asp Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Asp 
        35                  40                  45              


Arg Gly Ala Ala Gly Ala Ser Arg Leu Leu Glu Arg Leu Leu Pro Arg 
    50                  55                  60                  


His Asp Asp Phe Ser Arg Arg His Ile Gly Pro Gly Asp Lys Asp Arg 
65                  70                  75                  80  


Arg Glu Met Leu Gln Ala Leu Gly Leu Ala Ser Ile Asp Glu Leu Ile 
                85                  90                  95      


Glu Lys Thr Val Pro Ala Ser Ile Arg Leu Lys Arg Pro Leu Lys Met 
            100                 105                 110         


Glu Asp Pro Ile Cys Glu Asn Glu Ile Leu Glu Thr Leu His Ala Ile 
        115                 120                 125             


Ala Ser Lys Asn Gln Ile Trp Arg Ser Tyr Ile Gly Met Gly Tyr Tyr 
    130                 135                 140                 


Asn Cys Ser Val Pro Gln Thr Ile Leu Arg Asn Leu Leu Glu Asn Ser 
145                 150                 155                 160 


Gly Trp Val Thr Gln Tyr Thr Pro Tyr Gln Pro Glu Val Ser Gln Gly 
                165                 170                 175     


Arg Leu Glu Ser Leu Leu Asn Tyr Gln Thr Met Val Ser Asp Ile Thr 
            180                 185                 190         


Gly Leu Asp Met Ala Asn Ala Ser Leu Leu Asp Glu Ala Thr Ala Ala 
        195                 200                 205             


Ala Glu Ala Met Gln Leu Cys His Arg His Asn Lys Arg Lys Lys Phe 
    210                 215                 220                 


Phe Val Asp Pro Arg Cys His Pro Gln Thr Ile Ala Val Val Gln Thr 
225                 230                 235                 240 


Arg Ala Lys Tyr Arg Gly Val Leu Val Glu Leu Lys Leu Pro His Glu 
                245                 250                 255     


Met Asp Phe Ser Gly Lys Asp Val Cys Gly Val Leu Phe Gln Tyr Pro 
            260                 265                 270         


Asp Thr Glu Gly Lys Val Glu Asp Phe Thr Glu Leu Val Asp Arg Ala 
        275                 280                 285             


His Gln Thr Gly Ser Leu Thr Cys Cys Ala Thr Asp Leu Leu Ala Leu 
    290                 295                 300                 


Cys Ile Leu Arg Pro Pro Gly Glu Phe Gly Val Asp Ile Ala Leu Gly 
305                 310                 315                 320 


Asn Ser Gln Arg Phe Gly Val Pro Leu Gly Tyr Gly Gly Pro His Ala 
                325                 330                 335     


Ala Phe Phe Ala Val Lys Glu Asn Leu Val Arg Met Met Pro Gly Arg 
            340                 345                 350         


Met Val Gly Val Thr Arg Asp Ala Thr Gly Lys Glu Val Tyr Arg Leu 
        355                 360                 365             


Ala Leu Gln Thr Arg Glu Gln His Ile Arg Arg Asp Lys Ala Thr Ser 
    370                 375                 380                 


Asn Ile Cys Thr Ala Gln Ala Leu Leu Ala Asn Met Ala Ala Met Phe 
385                 390                 395                 400 


Ala Ile Tyr His Gly Ser Gln Gly Leu Lys His Ile Ala Lys Arg Val 
                405                 410                 415     


His Asn Ala Thr Leu Ile Leu Ser Glu Gly Leu Lys Arg Ala Gly His 
            420                 425                 430         


Gln Leu Gln His Asp Leu Phe Phe Asp Thr Leu Lys Val Gln Cys Gly 
        435                 440                 445             


Cys Ser Val Lys Glu Val Leu Gly Arg Ala Ala Gln Arg Gln Ile Asn 
    450                 455                 460                 


Phe Arg Leu Phe Asp Asp Gly Thr Leu Gly Ile Ser Leu Asp Glu Thr 
465                 470                 475                 480 


Val Thr Glu Lys Asp Leu Asp Asp Leu Leu Trp Ile Phe Gly Cys Glu 
                485                 490                 495     


Ser Ser Ala Glu Leu Val Ala Glu Gly Met Gly Glu Glu Arg Arg Gly 
            500                 505                 510         


Leu Leu Gly Ser Ser Phe Lys Arg Thr Ser Pro Phe Leu Thr His Gln 
        515                 520                 525             


Val Phe Asn Ser Tyr His Ser Glu Thr Asn Leu Val Arg Tyr Met Lys 
    530                 535                 540                 


Lys Leu Glu Asn Lys Asp Ile Ser Leu Val His Ser Met Ile Pro Leu 
545                 550                 555                 560 


Gly Ser Cys Thr Met Lys Leu Asn Ser Ser Ser Glu Leu Ala Pro Ile 
                565                 570                 575     


Thr Trp Arg Glu Phe Ala Asn Ile His Pro Phe Val Pro Leu Asp Gln 
            580                 585                 590         


Ala Gln Gly Tyr Gln Gln Leu Phe Gln Gly Leu Glu Lys Asp Leu Cys 
        595                 600                 605             


Glu Ile Thr Gly Tyr Asp Arg Val Ser Phe Gln Pro Asn Ser Gly Ala 
    610                 615                 620                 


Gln Gly Glu Tyr Ala Gly Leu Ala Thr Ile Arg Ala Tyr Leu Asp Gln 
625                 630                 635                 640 


Lys Gly Glu Arg His Arg Thr Val Cys Leu Ile Pro Lys Ser Ala His 
                645                 650                 655     


Gly Thr Asn Pro Ala Ser Ala His Met Ala Gly Met Lys Ile Gln Pro 
            660                 665                 670         


Val Glu Val Asp Arg Tyr Gly Asn Ile Asp Val Ala His Leu Lys Ala 
        675                 680                 685             


Met Val Asp Gln His Lys Glu Asn Leu Ala Ala Ile Met Ile Thr Tyr 
    690                 695                 700                 


Pro Ser Thr Asn Gly Val Phe Glu Glu Asn Ile Gly Asp Val Cys Ala 
705                 710                 715                 720 


Leu Ile His Gln His Gly Gly Gln Val Tyr Leu Asp Gly Ala Asn Met 
                725                 730                 735     


Asn Ala Gln Val Gly Ile Cys Arg Pro Gly Asp Phe Gly Ser Asp Val 
            740                 745                 750         


Ser His Leu Asn Leu His Lys Thr Phe Cys Ile Pro His Gly Gly Gly 
        755                 760                 765             


Gly Pro Gly Met Gly Pro Ile Gly Val Lys Lys His Leu Ser Pro Phe 
    770                 775                 780                 


Leu Pro Ser His Pro Val Ile Ser Ile Lys Pro Thr Glu Gly Thr Trp 
785                 790                 795                 800 


Pro Val Gly Thr Val Ser Ala Ala Pro Trp Gly Ser Ser Ser Ile Leu 
                805                 810                 815     


Pro Ile Ser Trp Ala Tyr Ile Lys Met Met Gly Gly Lys Gly Leu Lys 
            820                 825                 830         


Glu Ala Thr Glu Ile Ala Ile Leu Asn Ala Asn Tyr Met Ala Lys Arg 
        835                 840                 845             


Leu Glu Lys His Tyr Arg Val Leu Phe Arg Gly Ala Arg Gly Tyr Val 
    850                 855                 860                 


Ala His Glu Phe Ile Leu Asp Thr Arg Pro Phe Lys Lys Ser Ala Asn 
865                 870                 875                 880 


Val Glu Ala Val Asp Val Ala Lys Arg Leu Gln Asp Tyr Gly Phe His 
                885                 890                 895     


Ala Pro Thr Met Ser Trp Pro Val Ala Gly Thr Leu Met Ile Glu Pro 
            900                 905                 910         


Thr Glu Ser Glu Asp Lys Ala Glu Leu Asp Arg Phe Cys Asp Ala Met 
        915                 920                 925             


Ile Ser Ile Arg Gln Glu Ile Ala Asp Ile Glu Glu Gly Arg Ile Asp 
    930                 935                 940                 


Pro Arg Val Asn Pro Leu Lys Met Ser Pro His Ser Leu Thr Cys Val 
945                 950                 955                 960 


Thr Ser Ser Cys Trp Asp Arg Pro Tyr Ser Arg Glu Val Ala Ala Phe 
                965                 970                 975     


Pro Leu Pro Phe Val Lys Pro Glu Asn Lys Phe Trp Pro Thr Ile Ala 
            980                 985                 990         


Arg Ile Asp Asp Ile Tyr Gly Asp  Gln His Leu Val Cys  Thr Cys Pro 
        995                 1000                 1005             


Pro Met  Glu Val Tyr Glu Ser  Pro Phe Ser Glu Gln  Lys Arg Ala 
    1010                 1015                 1020             


Ser Ser  
    1025 


<210>  27
<211>  577
<212>  PRT
<213>  Mus musculus

<400>  27

Met Met Lys Ile Arg His Lys Asn Lys Lys Pro Gly Lys Gly Ser Lys 
1               5                   10                  15      


Gly Cys Lys Lys Pro Ala Arg Gln Asn Gly Lys Lys Val Thr Ser Arg 
            20                  25                  30          


Pro Ser Ser Ala Pro Gln Ile Val His Gly Asn Asp His Ala Ser Arg 
        35                  40                  45              


Glu Ala Glu Leu Lys Lys Lys Arg Val Glu Glu Met Arg Glu Lys Gln 
    50                  55                  60                  


Gln Val Ala Arg Glu Gln Glu Arg Gln Arg His Arg Thr Met Glu Ser 
65                  70                  75                  80  


Tyr Cys Gln Asp Val Leu Lys Arg Gln Gln Glu Phe Glu Gln Lys Glu 
                85                  90                  95      


Glu Val Leu Gln Glu Leu Asn Met Phe Pro Gln Leu Asp Asp Glu Ala 
            100                 105                 110         


Thr Arg Lys Ala Tyr Tyr Lys Glu Phe Arg Lys Val Val Glu Tyr Ser 
        115                 120                 125             


Asp Val Ile Leu Glu Val Leu Asp Ala Arg Asp Pro Leu Gly Cys Arg 
    130                 135                 140                 


Cys Phe Gln Met Glu Glu Thr Val Leu Arg Ala Glu Gly Asn Lys Lys 
145                 150                 155                 160 


Leu Val Leu Val Leu Asn Lys Ile Asp Leu Val Pro Lys Glu Ile Val 
                165                 170                 175     


Glu Lys Trp Leu Glu Tyr Leu Leu Asn Glu Leu Pro Thr Val Ala Phe 
            180                 185                 190         


Lys Ala Ser Thr Gln His His Gln Val Lys Asn Leu Thr Arg Cys Lys 
        195                 200                 205             


Val Pro Val Asp Gln Ala Ser Glu Ser Leu Leu Lys Ser Arg Ala Cys 
    210                 215                 220                 


Phe Gly Ala Glu Asn Leu Met Arg Val Leu Gly Asn Tyr Cys Arg Leu 
225                 230                 235                 240 


Gly Glu Val Arg Gly His Ile Arg Val Gly Val Val Gly Leu Pro Asn 
                245                 250                 255     


Val Gly Lys Ser Ser Leu Ile Asn Ser Leu Lys Arg Ser Arg Ala Cys 
            260                 265                 270         


Ser Val Gly Ala Val Pro Gly Val Thr Lys Phe Met Gln Glu Val Tyr 
        275                 280                 285             


Leu Asp Lys Phe Ile Arg Leu Leu Asp Ala Pro Gly Ile Val Pro Gly 
    290                 295                 300                 


Pro Asn Ser Glu Val Gly Thr Ile Leu Arg Asn Cys Ile His Val Gln 
305                 310                 315                 320 


Lys Leu Ala Asp Pro Val Thr Pro Val Glu Thr Ile Leu Gln Arg Cys 
                325                 330                 335     


Asn Leu Glu Glu Ile Ser Ser Tyr Tyr Gly Val Ser Gly Phe Gln Thr 
            340                 345                 350         


Thr Glu His Phe Leu Thr Ala Val Ala His Arg Leu Gly Lys Lys Lys 
        355                 360                 365             


Lys Gly Gly Val Tyr Ser Gln Glu Gln Ala Ala Lys Ala Val Leu Ala 
    370                 375                 380                 


Asp Trp Val Ser Gly Lys Ile Ser Phe Tyr Thr Leu Pro Pro Pro Thr 
385                 390                 395                 400 


His Thr Leu Pro Thr His Leu Ser Ala Glu Ile Val Lys Glu Met Thr 
                405                 410                 415     


Glu Val Phe Asp Ile Glu Asp Thr Glu His Ala Asn Glu Asp Thr Met 
            420                 425                 430         


Glu Cys Leu Ala Val Gly Glu Ser Asp Glu Leu Leu Gly Asp Met Asp 
        435                 440                 445             


Pro Gln Glu Met Glu Val Arg Trp Leu His Ser Pro Leu Val Lys Ile 
    450                 455                 460                 


Ala Asp Ala Ile Glu Asn Arg Ser Thr Val Tyr Lys Ile Gly Asn Leu 
465                 470                 475                 480 


Thr Gly Tyr Cys Thr Lys Pro Asn Arg Asn Gln Met Gly Trp Pro Lys 
                485                 490                 495     


Arg Asn Val Asp His His Cys Pro Gln Asn Asn Arg Val Val Glu Val 
            500                 505                 510         


Ser Ser Val Asp Arg Arg Pro Met Leu Gln Arg Ile Leu Glu Thr Asp 
        515                 520                 525             


Pro Leu Gln Gln Gly Gln Ala Leu Ala Ser Ala Leu Lys Asn Lys Lys 
    530                 535                 540                 


Lys Leu Gln Lys Arg Ser Asp Lys Ile Ala Thr Lys Leu Ser Asp Ser 
545                 550                 555                 560 


Met Met Ser Met Leu Asp Leu Ser Gly Asn Ser Asp Asp Cys Ala Gly 
                565                 570                 575     


Asp 
    


<210>  28
<211>  526
<212>  PRT
<213>  Mus musculus

<400>  28

Met Arg Gly Ser Pro Ala Pro Ser Ser Ala Ser Ser Ser Ala Ser Asp 
1               5                   10                  15      


Leu Ser Arg Ser Pro Ala His Ser Arg Ser Asp Leu Arg Pro Gly Thr 
            20                  25                  30          


Ala Gly Asp Tyr Ser Leu Ser Ala Ser Leu Ser Ala Cys Thr Leu Leu 
        35                  40                  45              


Ser Glu Gly Ala Val Glu Pro Met Gln Ile Asp Val Asp Pro Gln Glu 
    50                  55                  60                  


Asp Pro Gln Asn Ala Pro Asp Val Asn Tyr Val Val Glu Asn Pro Thr 
65                  70                  75                  80  


Leu Asp Leu Glu Gln Tyr Ala Ala Ser Tyr Ser Gly Leu Met Arg Ile 
                85                  90                  95      


Glu Arg Leu Gln Phe Ile Ala Asp Arg Cys Pro Pro Leu Arg Val Glu 
            100                 105                 110         


Ala Leu Lys Met Ala Leu Ser Phe Val Gln Arg Thr Phe Asn Val Asp 
        115                 120                 125             


Met Tyr Glu Glu Ile His Arg Lys Leu Ser Glu Ala Thr Arg Glu Leu 
    130                 135                 140                 


Gln Asn Ala Pro Asp Ala Ile Pro Glu Ser Gly Val Glu Pro Pro Pro 
145                 150                 155                 160 


Leu Asp Thr Ala Trp Val Glu Ala Thr Arg Lys Lys Ala Leu Leu Lys 
                165                 170                 175     


Leu Glu Lys Leu Asp Thr Asp Leu Lys Asn Tyr Lys Gly Asn Ser Ile 
            180                 185                 190         


Lys Glu Ser Ile Arg Arg Gly His Asp Asp Leu Gly Asp His Tyr Leu 
        195                 200                 205             


Asp Cys Gly Asp Leu Ser Asn Ala Leu Lys Cys Tyr Ser Arg Ala Arg 
    210                 215                 220                 


Asp Tyr Cys Thr Ser Ala Lys His Val Ile Asn Met Cys Leu Asn Val 
225                 230                 235                 240 


Ile Lys Val Ser Val Tyr Leu Gln Asn Trp Ser His Val Leu Ser Tyr 
                245                 250                 255     


Val Ser Lys Ala Glu Ser Thr Pro Glu Ile Ala Glu Gln Arg Gly Glu 
            260                 265                 270         


Arg Asp Ser Gln Thr Gln Ala Ile Leu Thr Lys Leu Lys Cys Ala Ala 
        275                 280                 285             


Gly Leu Ala Glu Leu Ala Ala Arg Lys Tyr Lys Gln Ala Ala Lys Cys 
    290                 295                 300                 


Phe Leu Leu Ala Ser Phe Asp His Cys Asp Phe Pro Glu Leu Leu Ser 
305                 310                 315                 320 


Pro Ser Asn Val Ala Val Tyr Gly Gly Leu Cys Ala Leu Ala Thr Phe 
                325                 330                 335     


Asp Arg Gln Glu Leu Gln Arg Asn Val Ile Ser Ser Ser Ser Phe Lys 
            340                 345                 350         


Leu Phe Leu Glu Leu Glu Pro Gln Val Arg Asp Ile Ile Phe Lys Phe 
        355                 360                 365             


Tyr Glu Ser Lys Tyr Ala Ser Cys Leu Lys Met Leu Asp Glu Met Lys 
    370                 375                 380                 


Asp Asn Leu Leu Leu Asp Met Tyr Leu Ala Pro His Val Arg Thr Leu 
385                 390                 395                 400 


Tyr Thr Gln Ile Arg Asn Arg Ala Leu Ile Gln Tyr Phe Ser Pro Tyr 
                405                 410                 415     


Val Ser Ala Asp Met His Lys Met Ala Ala Ala Phe Asn Thr Thr Val 
            420                 425                 430         


Ala Ala Leu Glu Asp Glu Leu Thr Gln Leu Ile Leu Glu Gly Leu Ile 
        435                 440                 445             


Asn Ala Arg Ile Asp Ser His Ser Lys Ile Leu Tyr Ala Arg Asp Val 
    450                 455                 460                 


Asp Gln Arg Ser Thr Thr Phe Glu Lys Ser Leu Leu Met Gly Lys Glu 
465                 470                 475                 480 


Phe Gln Arg Arg Ala Lys Ala Met Ile Leu Arg Ala Ala Val Leu Arg 
                485                 490                 495     


Asn Gln Ile His Val Lys Ser Pro Pro Arg Glu Gly Ser Gln Gly Glu 
            500                 505                 510         


Leu Thr Pro Ala Asn Ser Gln Ser Arg Met Ser Thr Asn Met 
        515                 520                 525     


<210>  29
<211>  646
<212>  PRT
<213>  Mus musculus

<400>  29

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 
545                 550                 555                 560 


Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 
                565                 570                 575     


Ile Ile Ser Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe 
            580                 585                 590         


Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr 
        595                 600                 605             


Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly 
    610                 615                 620                 


Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro 
625                 630                 635                 640 


Thr Ile Glu Glu Val Asp 
                645     


<210>  30
<211>  538
<212>  PRT
<213>  Mus musculus

<400>  30

Met Ser Thr Pro Gly Lys Glu Asn Phe Arg Leu Lys Ser Tyr Lys Asn 
1               5                   10                  15      


Lys Ser Leu Asn Pro Asp Glu Met Arg Arg Arg Arg Glu Glu Glu Gly 
            20                  25                  30          


Leu Gln Leu Arg Lys Gln Lys Arg Glu Glu Gln Leu Phe Lys Arg Arg 
        35                  40                  45              


Asn Val Ala Thr Ala Glu Glu Glu Thr Glu Glu Glu Val Met Ser Asp 
    50                  55                  60                  


Gly Gly Phe His Glu Ala Gln Ile Asn Asn Met Glu Met Ala Pro Gly 
65                  70                  75                  80  


Gly Val Ile Thr Ser Asp Met Thr Asp Met Ile Phe Ser Asn Ser Pro 
                85                  90                  95      


Glu Gln Gln Leu Ser Ala Thr Gln Lys Phe Arg Lys Leu Leu Ser Lys 
            100                 105                 110         


Glu Pro Asn Pro Pro Ile Asp Glu Val Ile Asn Thr Pro Gly Val Val 
        115                 120                 125             


Ala Arg Phe Val Glu Phe Leu Lys Arg Lys Glu Asn Cys Thr Leu Gln 
    130                 135                 140                 


Phe Glu Ser Ala Trp Val Leu Thr Asn Ile Ala Ser Gly Asn Ser Leu 
145                 150                 155                 160 


Gln Thr Arg Asn Val Ile Gln Ala Gly Ala Val Pro Ile Phe Ile Glu 
                165                 170                 175     


Leu Leu Ser Ser Glu Phe Glu Asp Val Gln Glu Gln Ala Val Trp Ala 
            180                 185                 190         


Leu Gly Asn Ile Ala Gly Asp Ser Thr Met Cys Arg Asp Tyr Val Leu 
        195                 200                 205             


Asn Cys Asn Ile Leu Pro Pro Leu Leu Gln Leu Phe Ser Lys Gln Asn 
    210                 215                 220                 


Arg Leu Thr Met Thr Arg Asn Ala Val Trp Ala Leu Ser Asn Leu Cys 
225                 230                 235                 240 


Arg Gly Lys Ser Pro Pro Pro Glu Phe Ala Lys Val Ser Pro Cys Leu 
                245                 250                 255     


Asn Val Leu Ser Trp Leu Leu Phe Val Ser Asp Thr Asp Val Leu Ala 
            260                 265                 270         


Asp Ala Cys Trp Ala Leu Ser Tyr Leu Ser Asp Gly Pro Asn Asp Lys 
        275                 280                 285             


Ile Gln Ala Val Ile Asp Ala Gly Val Cys Arg Arg Leu Val Glu Leu 
    290                 295                 300                 


Leu Met His Asn Asp Tyr Lys Val Val Ser Pro Ala Leu Arg Ala Val 
305                 310                 315                 320 


Gly Asn Ile Val Thr Gly Asp Asp Ile Gln Thr Gln Val Ile Leu Asn 
                325                 330                 335     


Cys Ser Ala Leu Gln Ser Leu Leu His Leu Leu Ser Ser Pro Lys Glu 
            340                 345                 350         


Ser Ile Lys Lys Glu Ala Cys Trp Thr Ile Ser Asn Ile Thr Ala Gly 
        355                 360                 365             


Asn Arg Ala Gln Ile Gln Thr Val Ile Asp Ala Asn Met Phe Pro Ala 
    370                 375                 380                 


Leu Ile Ser Ile Leu Gln Thr Ala Glu Phe Arg Thr Arg Lys Glu Ala 
385                 390                 395                 400 


Ala Trp Ala Ile Thr Asn Ala Thr Ser Gly Gly Ser Ala Glu Gln Ile 
                405                 410                 415     


Lys Tyr Leu Val Glu Leu Gly Cys Ile Lys Pro Leu Cys Asp Leu Leu 
            420                 425                 430         


Thr Val Met Asp Ala Lys Ile Val Gln Val Ala Leu Asn Gly Leu Glu 
        435                 440                 445             


Asn Ile Leu Arg Leu Gly Glu Gln Glu Ala Lys Arg Asn Gly Ser Gly 
    450                 455                 460                 


Ile Asn Pro Tyr Cys Ala Leu Ile Glu Glu Ala Tyr Gly Leu Asp Lys 
465                 470                 475                 480 


Ile Glu Phe Leu Gln Ser His Glu Asn Gln Glu Ile Tyr Gln Lys Ala 
                485                 490                 495     


Phe Asp Leu Ile Glu His Tyr Phe Gly Thr Glu Asp Glu Asp Ser Ser 
            500                 505                 510         


Ile Ala Pro Gln Val Asp Leu Ser Gln Gln Gln Tyr Ile Phe Gln Gln 
        515                 520                 525             


Cys Glu Ala Pro Met Glu Gly Phe Gln Leu 
    530                 535             


<210>  31
<211>  358
<212>  PRT
<213>  Mus musculus

<400>  31

Met Ala Ala Ala Ala Ala Ala Gly Pro Glu Met Val Arg Gly Gln Val 
1               5                   10                  15      


Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly Glu Gly 
            20                  25                  30          


Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Leu Asn Lys Val Arg 
        35                  40                  45              


Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr Cys Gln 
    50                  55                  60                  


Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His Glu Asn 
65                  70                  75                  80  


Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu Gln Met 
                85                  90                  95      


Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu Tyr Lys 
            100                 105                 110         


Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr Phe Leu 
        115                 120                 125             


Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn Val Leu 
    130                 135                 140                 


His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr Cys Asp 
145                 150                 155                 160 


Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro Asp His 
                165                 170                 175     


Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp Tyr Arg 
            180                 185                 190         


Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser Ile Asp 
        195                 200                 205             


Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn Arg Pro 
    210                 215                 220                 


Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile Leu Gly 
225                 230                 235                 240 


Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile Asn Leu 
                245                 250                 255     


Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys Val Pro 
            260                 265                 270         


Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp Leu Leu 
        275                 280                 285             


Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val Glu Gln 
    290                 295                 300                 


Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser Asp Glu 
305                 310                 315                 320 


Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp Asp Leu 
                325                 330                 335     


Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala Arg Phe 
            340                 345                 350         


Gln Pro Gly Tyr Arg Ser 
        355             


<210>  32
<211>  812
<212>  PRT
<213>  Mus musculus

<400>  32

Met Ala Gly Thr Val Val Leu Asp Asp Val Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Arg Asp Tyr Leu Asp Phe Leu Asp Asp Glu Glu Asp Gln Gly Ile Tyr 
            20                  25                  30          


Gln Asn Lys Val Arg Glu Leu Ile Ser Asp Asn Gln Tyr Arg Leu Ile 
        35                  40                  45              


Val Ser Val Asn Asp Leu Arg Arg Lys Asn Glu Lys Arg Ala Asn Arg 
    50                  55                  60                  


Leu Leu Asn Asn Ala Phe Glu Glu Leu Val Ala Phe Gln Arg Ala Leu 
65                  70                  75                  80  


Lys Asp Phe Val Ala Ser Ile Asp Ala Thr Tyr Ala Lys Gln Tyr Glu 
                85                  90                  95      


Glu Phe Tyr Ile Gly Leu Glu Gly Ser Phe Gly Ser Lys His Val Ser 
            100                 105                 110         


Pro Arg Thr Leu Thr Ser Cys Phe Leu Ser Cys Val Val Cys Val Glu 
        115                 120                 125             


Gly Ile Val Thr Lys Cys Ser Leu Val Arg Pro Lys Val Val Arg Ser 
    130                 135                 140                 


Val His Tyr Cys Pro Ala Thr Lys Lys Thr Ile Glu Arg Arg Tyr Ser 
145                 150                 155                 160 


Asp Leu Thr Thr Leu Val Ala Phe Pro Ser Ser Ser Val Tyr Pro Thr 
                165                 170                 175     


Lys Asp Glu Glu Asn Asn Pro Leu Glu Thr Glu Tyr Gly Leu Ser Val 
            180                 185                 190         


Tyr Lys Asp His Gln Thr Ile Thr Ile Gln Glu Met Pro Glu Lys Ala 
        195                 200                 205             


Pro Ala Gly Gln Leu Pro Arg Ser Val Asp Val Ile Leu Asp Asp Asp 
    210                 215                 220                 


Leu Val Asp Lys Val Lys Pro Gly Asp Arg Ile Gln Val Val Gly Thr 
225                 230                 235                 240 


Tyr Arg Cys Leu Pro Gly Lys Lys Gly Cys Tyr Thr Ser Gly Thr Phe 
                245                 250                 255     


Arg Thr Val Leu Ile Ala Cys Asn Val Lys Gln Met Ser Lys Asp Ile 
            260                 265                 270         


Gln Pro Ala Phe Ser Ala Asp Asp Ile Ala Lys Ile Lys Lys Phe Ser 
        275                 280                 285             


Lys Thr Arg Ser Lys Asp Val Phe Glu Gln Leu Ala Arg Ser Leu Ala 
    290                 295                 300                 


Pro Ser Ile His Gly His Asp Tyr Val Lys Lys Ala Ile Leu Cys Leu 
305                 310                 315                 320 


Leu Leu Gly Gly Val Glu Arg Glu Leu Glu Asn Gly Ser His Ile Arg 
                325                 330                 335     


Gly Asp Ile Asn Ile Leu Leu Ile Gly Asp Pro Ser Val Ala Lys Ser 
            340                 345                 350         


Gln Leu Leu Arg Tyr Val Leu Cys Thr Ala Pro Arg Ala Ile Pro Thr 
        355                 360                 365             


Thr Gly Arg Gly Ser Ser Gly Val Gly Leu Thr Ala Ala Val Thr Thr 
    370                 375                 380                 


Asp Gln Glu Thr Gly Glu Arg Arg Leu Glu Ala Gly Ala Met Val Leu 
385                 390                 395                 400 


Ala Asp Arg Gly Val Val Cys Ile Asp Glu Phe Asp Lys Met Ser Asp 
                405                 410                 415     


Met Asp Arg Thr Ala Ile His Glu Val Met Glu Gln Gly Arg Val Thr 
            420                 425                 430         


Ile Ala Lys Ala Gly Ile His Ala Arg Leu Asn Ala Arg Cys Ser Val 
        435                 440                 445             


Leu Ala Ala Ala Asn Pro Val Tyr Gly Arg Tyr Asp Gln Tyr Lys Thr 
    450                 455                 460                 


Pro Met Glu Asn Ile Gly Leu Gln Asp Ser Leu Leu Ser Arg Phe Asp 
465                 470                 475                 480 


Leu Leu Phe Ile Met Leu Asp Gln Met Asp Pro Glu Gln Asp Arg Glu 
                485                 490                 495     


Ile Ser Asp His Val Leu Arg Met His Gln Tyr Arg Ala Pro Gly Glu 
            500                 505                 510         


Gln Asp Gly Asp Ala Leu Pro Leu Gly Ser Ser Val Asp Ile Leu Ala 
        515                 520                 525             


Thr Asp Asp Pro Asp Phe Thr Gln Asp Asp Gln Gln Asp Thr Arg Ile 
    530                 535                 540                 


Tyr Glu Lys His Asp Ser Leu Leu His Gly Thr Lys Lys Lys Lys Glu 
545                 550                 555                 560 


Lys Met Val Ser Ala Ala Phe Met Lys Lys Tyr Ile His Val Ala Lys 
                565                 570                 575     


Ile Ile Lys Pro Thr Leu Thr Gln Glu Ser Ala Ala Tyr Ile Ala Glu 
            580                 585                 590         


Glu Tyr Ser Arg Leu Arg Ser Gln Asp Ser Met Ser Ser Asp Thr Ala 
        595                 600                 605             


Arg Thr Ser Pro Val Thr Ala Arg Thr Leu Glu Thr Leu Ile Arg Leu 
    610                 615                 620                 


Ala Thr Ala His Ala Lys Ala Arg Met Ser Lys Thr Val Asp Leu Gln 
625                 630                 635                 640 


Asp Ala Glu Glu Ala Val Glu Leu Val Gln Tyr Ala Tyr Phe Lys Lys 
                645                 650                 655     


Val Leu Glu Lys Glu Lys Lys Arg Lys Lys Ala Ser Glu Asp Glu Ser 
            660                 665                 670         


Asp Leu Glu Asp Glu Glu Glu Lys Ser Gln Glu Asp Thr Glu Gln Lys 
        675                 680                 685             


Arg Lys Arg Arg Lys Thr His Ala Lys Asp Gly Glu Ser Tyr Asp Pro 
    690                 695                 700                 


Tyr Asp Phe Ser Glu Ala Glu Thr Gln Met Pro Gln Val His Thr Pro 
705                 710                 715                 720 


Lys Thr Asp Asp Ser Gln Glu Lys Thr Asp Asp Ser Gln Glu Thr Gln 
                725                 730                 735     


Asp Ser Gln Lys Val Glu Leu Ser Glu Pro Arg Leu Lys Ala Phe Lys 
            740                 745                 750         


Ala Ala Leu Leu Glu Val Phe Gln Glu Ala His Glu Gln Ser Val Gly 
        755                 760                 765             


Met Leu His Leu Thr Glu Ser Ile Asn Arg Asn Arg Glu Glu Pro Phe 
    770                 775                 780                 


Ser Ser Glu Glu Ile Gln Ala Cys Leu Ser Arg Met Gln Asp Asp Asn 
785                 790                 795                 800 


Gln Val Met Val Ser Glu Gly Ile Val Phe Leu Ile 
                805                 810         


<210>  33
<211>  734
<212>  PRT
<213>  Mus musculus

<400>  33

Met Ser Gly Phe Asp Asp Pro Gly Ile Phe Tyr Ser Asp Ser Phe Gly 
1               5                   10                  15      


Gly Asp Pro Gly Ala Glu Glu Gly Gln Ala Arg Lys Ser Gln Leu Gln 
            20                  25                  30          


Arg Arg Phe Lys Glu Phe Leu Arg Gln Tyr Arg Val Gly Thr Asp Arg 
        35                  40                  45              


Thr Gly Phe Thr Phe Lys Tyr Arg Asp Glu Leu Lys Arg His Tyr Asn 
    50                  55                  60                  


Leu Gly Glu Tyr Trp Ile Glu Val Glu Met Glu Asp Leu Ala Ser Phe 
65                  70                  75                  80  


Asp Glu Glu Leu Ala Asp His Leu His Lys Gln Pro Ala Glu His Leu 
                85                  90                  95      


Gln Leu Leu Glu Glu Ala Ala Lys Glu Val Ala Asp Glu Val Thr Arg 
            100                 105                 110         


Pro Arg Pro Ala Gly Asp Glu Leu Leu Gln Asp Ile Gln Val Met Leu 
        115                 120                 125             


Lys Ser Asp Ala Ser Pro Ser Ser Ile Arg Ile Leu Lys Ser Asp Met 
    130                 135                 140                 


Met Ser His Leu Val Lys Ile Pro Gly Ile Ile Ile Ser Ala Ser Ala 
145                 150                 155                 160 


Val Arg Ala Lys Ala Thr Arg Ile Ser Ile Gln Cys Arg Ser Cys His 
                165                 170                 175     


Asn Thr Leu Thr Asn Ile Ala Met Arg Pro Gly Leu Glu Gly Tyr Ala 
            180                 185                 190         


Leu Pro Arg Lys Cys Asn Met Asp Gln Ala Gly Arg Pro Lys Cys Pro 
        195                 200                 205             


Leu Asp Pro Tyr Phe Ile Met Pro Asp Lys Cys Lys Cys Val Asp Phe 
    210                 215                 220                 


Gln Thr Leu Lys Leu Gln Glu Leu Pro Asp Ala Val Pro His Gly Glu 
225                 230                 235                 240 


Met Pro Arg His Met Gln Leu Tyr Cys Asp Arg Tyr Leu Cys Asp Lys 
                245                 250                 255     


Val Val Pro Gly Asn Arg Val Thr Ile Met Gly Ile Tyr Ser Ile Lys 
            260                 265                 270         


Lys Phe Gly Leu Asn Pro Ser Lys Gly Arg Asp Arg Val Gly Val Gly 
        275                 280                 285             


Ile Arg Ser Ser Tyr Ile Arg Val Leu Gly Ile Gln Val Asp Thr Asp 
    290                 295                 300                 


Gly Ser Gly Arg Ser Phe Ala Gly Ser Val Ser Pro Gln Glu Glu Glu 
305                 310                 315                 320 


Glu Phe Arg Arg Leu Ala Ala Leu Pro Asn Ile Tyr Glu Leu Ile Ser 
                325                 330                 335     


Lys Ser Ile Ser Pro Ser Ile Phe Gly Gly Met Asp Met Lys Lys Ala 
            340                 345                 350         


Ile Ala Cys Leu Leu Phe Gly Gly Ser Arg Lys Arg Leu Pro Asp Gly 
        355                 360                 365             


Leu Thr Arg Arg Gly Asp Ile Asn Leu Leu Met Leu Gly Asp Pro Gly 
    370                 375                 380                 


Thr Ala Lys Ser Gln Leu Leu Lys Phe Val Glu Lys Cys Ser Pro Ile 
385                 390                 395                 400 


Gly Val Tyr Thr Ser Gly Lys Gly Ser Ser Ala Ala Gly Leu Thr Ala 
                405                 410                 415     


Ser Val Ile Arg Asp Pro Ser Ser Arg Asn Phe Ile Met Glu Gly Gly 
            420                 425                 430         


Ala Met Val Leu Ala Asp Gly Gly Val Val Cys Ile Asp Glu Phe Asp 
        435                 440                 445             


Lys Met Arg Glu Asp Asp Arg Val Ala Ile His Glu Ala Met Glu Gln 
    450                 455                 460                 


Gln Thr Ile Ser Ile Ala Lys Ala Gly Ile Thr Thr Thr Leu Asn Ser 
465                 470                 475                 480 


Arg Cys Ser Val Leu Ala Ala Ala Asn Ser Val Phe Gly Arg Trp Asp 
                485                 490                 495     


Glu Thr Lys Gly Glu Asp Asn Ile Asp Phe Met Pro Thr Ile Leu Ser 
            500                 505                 510         


Arg Phe Asp Met Ile Phe Ile Val Lys Asp Glu His Asn Glu Glu Arg 
        515                 520                 525             


Asp Met Met Leu Ala Lys His Val Met Thr Leu His Val Ser Ala Leu 
    530                 535                 540                 


Thr Gln Thr Gln Ala Val Glu Gly Glu Ile Asp Leu Ala Lys Met Lys 
545                 550                 555                 560 


Lys Phe Ile Ala Tyr Cys Arg Ala Arg Cys Gly Pro Arg Leu Ser Ala 
                565                 570                 575     


Glu Ala Ala Glu Lys Leu Lys Asn Arg Tyr Ile Ile Met Arg Ser Gly 
            580                 585                 590         


Ala Arg Gln His Glu Arg Asp Ser Asp Arg Arg Ser Ser Ile Pro Ile 
        595                 600                 605             


Thr Val Arg Gln Leu Glu Ala Ile Val Arg Ile Ala Glu Ala Leu Ser 
    610                 615                 620                 


Lys Met Lys Leu Gln Pro Phe Ala Thr Glu Ala Asp Val Glu Glu Ala 
625                 630                 635                 640 


Leu Arg Leu Phe Gln Val Ser Thr Leu Asp Ala Ala Leu Ser Gly Asn 
                645                 650                 655     


Leu Ser Gly Val Glu Gly Phe Thr Thr Gln Glu Asp Gln Glu Met Leu 
            660                 665                 670         


Ser Arg Ile Glu Lys Gln Leu Lys Arg Arg Phe Ala Ile Gly Ser Gln 
        675                 680                 685             


Val Ser Glu His Ser Ile Val Gln Asp Phe Thr Lys Gln Lys Tyr Pro 
    690                 695                 700                 


Glu His Ala Ile Arg Lys Val Leu Gln Leu Met Leu Arg Arg Gly Glu 
705                 710                 715                 720 


Ile Gln His Arg Met Gln Arg Lys Val Leu Tyr Arg Leu Lys 
                725                 730                 


<210>  34
<211>  489
<212>  PRT
<213>  Mus musculus

<400>  34

Met Thr Ser His Ser Thr Ser Ala Gln Cys Ser Ala Ser Asp Ser Ala 
1               5                   10                  15      


Cys Arg Ile Ser Ser Glu Gln Ile Ser Gln Val Arg Pro Lys Leu Gln 
            20                  25                  30          


Leu Leu Lys Ile Leu His Ala Ala Gly Ala Gln Gly Glu Val Phe Thr 
        35                  40                  45              


Met Lys Glu Val Met His Tyr Leu Gly Gln Tyr Ile Met Val Lys Gln 
    50                  55                  60                  


Leu Tyr Asp Gln Gln Glu Gln His Met Val Tyr Cys Gly Gly Asp Leu 
65                  70                  75                  80  


Leu Gly Asp Leu Leu Gly Cys Gln Ser Phe Ser Val Lys Asp Pro Ser 
                85                  90                  95      


Pro Leu Tyr Asp Met Leu Arg Lys Asn Leu Val Thr Ser Ala Ser Ile 
            100                 105                 110         


Asn Thr Asp Ala Ala Gln Thr Leu Ala Leu Ala Gln Asp His Thr Met 
        115                 120                 125             


Asp Phe Pro Ser Gln Asp Arg Leu Lys His Gly Ala Thr Glu Tyr Ser 
    130                 135                 140                 


Asn Pro Arg Lys Arg Thr Glu Glu Glu Asp Thr His Thr Leu Pro Thr 
145                 150                 155                 160 


Ser Arg His Lys Cys Arg Asp Ser Arg Ala Asp Glu Asp Leu Ile Glu 
                165                 170                 175     


His Leu Ser Gln Asp Glu Thr Ser Arg Leu Asp Leu Asp Phe Glu Glu 
            180                 185                 190         


Trp Asp Val Ala Gly Leu Pro Trp Trp Phe Leu Gly Asn Leu Arg Asn 
        195                 200                 205             


Asn Cys Ile Pro Lys Ser Asn Gly Ser Thr Asp Leu Gln Thr Asn Gln 
    210                 215                 220                 


Asp Ile Gly Thr Ala Ile Val Ser Asp Thr Thr Asp Asp Leu Trp Phe 
225                 230                 235                 240 


Leu Asn Glu Thr Val Ser Glu Gln Leu Gly Val Gly Ile Lys Val Glu 
                245                 250                 255     


Ala Ala Asn Ser Glu Gln Thr Ser Glu Val Gly Lys Thr Ser Asn Lys 
            260                 265                 270         


Lys Thr Val Glu Val Gly Lys Asp Asp Asp Leu Glu Asp Ser Arg Ser 
        275                 280                 285             


Leu Ser Asp Asp Thr Asp Val Glu Leu Thr Ser Glu Asp Glu Trp Gln 
    290                 295                 300                 


Cys Thr Glu Cys Lys Lys Phe Asn Ser Pro Ser Lys Arg Tyr Cys Phe 
305                 310                 315                 320 


Arg Cys Trp Ala Leu Arg Lys Asp Trp Tyr Ser Asp Cys Ser Lys Leu 
                325                 330                 335     


Thr His Ser Leu Ser Thr Ser Asn Ile Thr Ala Ile Pro Glu Lys Lys 
            340                 345                 350         


Asp Asn Glu Gly Ile Asp Val Pro Asp Cys Arg Arg Thr Ile Ser Ala 
        355                 360                 365             


Pro Val Val Arg Pro Lys Asp Gly Tyr Leu Lys Glu Glu Lys Pro Arg 
    370                 375                 380                 


Phe Asp Pro Cys Asn Ser Val Gly Phe Leu Asp Leu Ala His Ser Ser 
385                 390                 395                 400 


Glu Ser Gln Glu Ile Ile Ser Ser Ala Arg Glu Gln Thr Asp Ile Phe 
                405                 410                 415     


Ser Glu Gln Lys Ala Glu Thr Glu Ser Met Glu Asp Phe Gln Asn Val 
            420                 425                 430         


Leu Lys Pro Cys Ser Leu Cys Glu Lys Arg Pro Arg Asp Gly Asn Ile 
        435                 440                 445             


Ile His Gly Lys Thr Ser His Leu Thr Thr Cys Phe His Cys Ala Arg 
    450                 455                 460                 


Arg Leu Lys Lys Ser Gly Ala Ser Cys Pro Ala Cys Lys Lys Glu Ile 
465                 470                 475                 480 


Gln Leu Val Ile Lys Val Phe Ile Ala 
                485                 


<210>  35
<211>  643
<212>  PRT
<213>  Mus musculus

<400>  35

Met Lys Asp Tyr Asp Glu Leu Leu Lys Tyr Tyr Glu Leu Tyr Glu Thr 
1               5                   10                  15      


Ile Gly Thr Gly Gly Phe Ala Lys Val Lys Leu Ala Cys His Val Leu 
            20                  25                  30          


Thr Gly Glu Met Val Ala Ile Lys Ile Met Asp Lys Asn Ala Leu Gly 
        35                  40                  45              


Ser Asp Leu Pro Arg Val Lys Thr Glu Ile Asp Ala Leu Lys Ser Leu 
    50                  55                  60                  


Arg His Gln His Ile Cys Gln Leu Tyr His Val Leu Glu Thr Lys Asn 
65                  70                  75                  80  


Lys Ile Phe Met Val Leu Glu Tyr Cys Pro Gly Gly Glu Leu Phe Asp 
                85                  90                  95      


Tyr Ile Ile Ser Gln Asp Arg Leu Ser Glu Glu Glu Thr Arg Val Val 
            100                 105                 110         


Phe Arg Gln Ile Leu Ser Ala Val Ala Tyr Val His Ser Gln Gly Tyr 
        115                 120                 125             


Ala His Arg Asp Leu Lys Pro Glu Asn Leu Leu Phe Asp Glu Asn His 
    130                 135                 140                 


Lys Leu Lys Leu Ile Asp Phe Gly Leu Cys Ala Lys Pro Lys Gly Asn 
145                 150                 155                 160 


Lys Asp Tyr His Leu Gln Thr Cys Cys Gly Ser Leu Ala Tyr Ala Ala 
                165                 170                 175     


Pro Glu Leu Ile Gln Gly Lys Ser Tyr Leu Gly Ser Glu Ala Asp Val 
            180                 185                 190         


Trp Ser Met Gly Ile Leu Leu Tyr Val Leu Met Cys Gly Phe Leu Pro 
        195                 200                 205             


Phe Asp Asp Asp Asn Val Met Ala Leu Tyr Lys Lys Ile Met Arg Gly 
    210                 215                 220                 


Lys Tyr Glu Val Pro Lys Trp Leu Ser Pro Ser Ser Ile Leu Leu Leu 
225                 230                 235                 240 


Gln Gln Met Leu Gln Val Asp Pro Lys Lys Arg Ile Ser Met Arg Asn 
                245                 250                 255     


Leu Leu Asn His Pro Trp Val Met Gln Asp Tyr Ser Cys Pro Val Glu 
            260                 265                 270         


Trp Gln Ser Lys Thr Pro Leu Thr His Leu Asp Glu Asp Cys Val Thr 
        275                 280                 285             


Glu Leu Ser Val His His Arg Ser Ser Arg Gln Thr Met Glu Asp Leu 
    290                 295                 300                 


Ile Ser Ser Trp Gln Tyr Asp His Leu Thr Ala Thr Tyr Leu Leu Leu 
305                 310                 315                 320 


Leu Ala Lys Lys Ala Arg Gly Lys Pro Ala Arg Leu Gln Leu Leu Ser 
                325                 330                 335     


Phe Ser Cys Gly Thr Ala Ser Thr Thr Pro Lys Ser Lys Asn Leu Ser 
            340                 345                 350         


Leu Glu Asp Met Ser Thr Ser Asp Asp Asn Cys Val Ala Gly Leu Ile 
        355                 360                 365             


Asp Tyr Glu Leu Cys Glu Asp Lys Leu Leu Ala Pro Lys Thr Pro Gln 
    370                 375                 380                 


Val Thr Lys His Leu Ala Glu Ser Asn His Ala Ala Ser Lys Ser Pro 
385                 390                 395                 400 


Ala Pro Gly Val Arg Arg Ala Val Ala Asn Lys Leu Met Asp Lys Glu 
                405                 410                 415     


Asn Val Cys Thr Pro Lys Ser Ser Val Lys Asn Glu Glu Gln Phe Val 
            420                 425                 430         


Phe Ser Glu Pro Lys Ile Pro Val Ser Lys Asn Gln Tyr Lys Arg Glu 
        435                 440                 445             


Ile Pro Ala Ser Pro Thr Arg Phe Pro Thr Pro Ala Lys Ala Arg Ala 
    450                 455                 460                 


Gln Cys Leu Arg Glu Ala Pro Val Arg Thr Pro Gly Asn Ser Ala Gly 
465                 470                 475                 480 


Ala Asp Thr Leu Thr Thr Gly Val Ile Ser Pro Glu Arg Arg Cys Arg 
                485                 490                 495     


Ser Met Asp Val Asp Leu Asn Gln Ala His Met Glu Asp Thr Pro Lys 
            500                 505                 510         


Lys Lys Gly Thr Asn Val Phe Gly Ser Leu Glu Arg Gly Leu Asp Lys 
        515                 520                 525             


Val Leu Thr Ala Leu Thr Arg Asn Lys Lys Lys Gly Ser Ala Arg Asp 
    530                 535                 540                 


Gly Pro Arg Lys Arg Lys Leu His Tyr Asn Val Thr Thr Thr Arg Leu 
545                 550                 555                 560 


Val Asn Pro Asp Gln Leu Leu Ser Glu Ile Met Ala Ile Leu Pro Lys 
                565                 570                 575     


Lys Asn Val Asp Phe Val Gln Lys Gly Tyr Thr Leu Lys Cys Gln Thr 
            580                 585                 590         


Gln Ser Asp Phe Gly Lys Val Thr Met Gln Phe Glu Leu Glu Val Cys 
        595                 600                 605             


Gln Leu Gln Arg Pro Asp Val Val Gly Ile Arg Arg Gln Arg Leu Lys 
    610                 615                 620                 


Gly Asp Ala Trp Val Tyr Lys Arg Leu Val Glu Asp Ile Leu Ser Gly 
625                 630                 635                 640 


Cys Lys Met 
            


<210>  36
<211>  283
<212>  PRT
<213>  Mus musculus

<400>  36

Met Ala Ser Gly Ser Ala Cys Thr Ala Val Lys Ile Gly Ile Ile Gly 
1               5                   10                  15      


Gly Thr Gly Leu Asp Asp Pro Glu Ile Leu Glu Gly Arg Thr Glu Lys 
            20                  25                  30          


Tyr Val Asp Thr Pro Phe Gly Lys Pro Ser Asp Ala Leu Ile Leu Gly 
        35                  40                  45              


Lys Ile Lys Asn Val Asp Cys Val Leu Leu Ala Arg His Gly Arg Gln 
    50                  55                  60                  


His Thr Ile Met Pro Ser Lys Val Asn Tyr Gln Ala Asn Ile Trp Ala 
65                  70                  75                  80  


Leu Lys Glu Glu Gly Cys Thr His Val Ile Val Thr Thr Ala Cys Gly 
                85                  90                  95      


Ser Leu Arg Glu Glu Ile Gln Pro Gly Asp Met Val Ile Ile Asp Gln 
            100                 105                 110         


Phe Ile Asp Arg Thr Ser Leu Arg Pro Gln Thr Phe Tyr Asp Gly Ser 
        115                 120                 125             


His Cys Ser Ala Arg Gly Val Cys His Ile Pro Met Ala Glu Pro Phe 
    130                 135                 140                 


Cys Pro Lys Thr Arg Glu Val Leu Ile Glu Thr Ala Lys Lys Leu Gly 
145                 150                 155                 160 


Leu Arg Cys His Ser Lys Gly Thr Ile Val Thr Ile Glu Gly Pro Arg 
                165                 170                 175     


Phe Ser Ser Arg Ala Glu Ser Leu Ile Phe Arg Thr Trp Gly Ala Asp 
            180                 185                 190         


Val Val Asn Met Thr Thr Val Pro Glu Val Val Leu Ala Lys Glu Ala 
        195                 200                 205             


Gly Ile Cys Tyr Ala Ser Ile Ala Met Ala Thr Asp Tyr Asp Cys Trp 
    210                 215                 220                 


Lys Glu His Glu Glu Ala Val Ser Val Asp Gly Val Leu Lys Thr Met 
225                 230                 235                 240 


Lys Glu Asn Ala Asn Lys Ala Lys Ser Leu Leu Leu Thr Thr Ile Pro 
                245                 250                 255     


Gln Ile Gly Ser Met Glu Trp Ser Glu Thr Leu Arg Asn Leu Lys Asn 
            260                 265                 270         


Met Ala Gln Phe Ser Val Leu Pro Pro Arg His 
        275                 280             


<210>  37
<211>  887
<212>  PRT
<213>  Mus musculus

<400>  37

Met Ser Ser Asp Met Ala Ala Asp Glu Ser Glu Ala Pro Val Leu Ser 
1               5                   10                  15      


Glu Asp Glu Val Trp Glu Phe Cys Leu Asp Lys Thr Glu Asp Gly Gly 
            20                  25                  30          


Gly Ser Pro Gly Ser Asp Val Thr Asp Thr Cys Glu Pro Pro Cys Gly 
        35                  40                  45              


Cys Trp Glu Leu Asn Pro Asn Ser Leu Glu Glu Glu His Val Leu Phe 
    50                  55                  60                  


Thr Ala Asp Pro Tyr Leu Glu Leu His Asn Asp Asp Thr Arg Val Val 
65                  70                  75                  80  


Arg Val Lys Val Ile Ala Gly Ile Gly Leu Ala Lys Lys Asp Ile Leu 
                85                  90                  95      


Gly Ala Ser Asp Pro Tyr Val Arg Val Thr Leu Tyr Asp Pro Met Ser 
            100                 105                 110         


Gly Ile Leu Thr Ser Val Gln Thr Lys Thr Ile Lys Lys Ser Leu Asn 
        115                 120                 125             


Pro Lys Trp Asn Glu Glu Ile Leu Phe Arg Val Leu Pro Gln Arg His 
    130                 135                 140                 


Arg Ile Leu Phe Glu Val Phe Asp Glu Asn Arg Leu Thr Arg Asp Asp 
145                 150                 155                 160 


Phe Leu Gly Gln Val Asp Val Pro Leu Tyr Pro Leu Pro Thr Glu Asn 
                165                 170                 175     


Pro Arg Met Glu Arg Pro Tyr Thr Phe Lys Asp Phe Val Leu His Pro 
            180                 185                 190         


Arg Ser His Lys Ser Arg Val Lys Gly Tyr Leu Arg Leu Lys Met Thr 
        195                 200                 205             


Tyr Leu Pro Lys Asn Gly Ser Glu Asp Glu Asn Ala Asp Gln Ala Glu 
    210                 215                 220                 


Glu Leu Glu Pro Gly Trp Val Val Leu Asp Gln Pro Asp Ala Ala Thr 
225                 230                 235                 240 


His Leu Pro His Pro Pro Glu Pro Ser Pro Leu Pro Pro Gly Trp Glu 
                245                 250                 255     


Glu Arg Gln Asp Val Leu Gly Arg Thr Tyr Tyr Val Asn His Glu Ser 
            260                 265                 270         


Arg Arg Thr Gln Trp Lys Arg Pro Ser Pro Asp Asp Asp Leu Thr Asp 
        275                 280                 285             


Glu Asp Asn Asp Asp Met Gln Leu Gln Ala Gln Arg Ala Phe Thr Thr 
    290                 295                 300                 


Arg Arg Gln Ile Ser Glu Asp Val Asp Gly Pro Asp Asn Arg Glu Ser 
305                 310                 315                 320 


Pro Glu Asn Trp Glu Ile Val Arg Glu Asp Glu Asn Thr Glu Tyr Ser 
                325                 330                 335     


Gly Gln Ala Val Gln Ser Pro Pro Ser Gly His Ile Asp Val Gln Thr 
            340                 345                 350         


His Leu Ala Glu Glu Phe Asn Thr Arg Leu Ala Val Cys Gly Asn Pro 
        355                 360                 365             


Ala Thr Ser Gln Pro Val Thr Ser Ser Asn His Ser Ser Arg Gly Gly 
    370                 375                 380                 


Ser Leu Gln Thr Cys Ile Phe Glu Glu Gln Pro Thr Leu Pro Val Leu 
385                 390                 395                 400 


Leu Pro Thr Ser Ser Gly Leu Pro Pro Gly Trp Glu Glu Lys Gln Asp 
                405                 410                 415     


Asp Arg Gly Arg Ser Tyr Tyr Val Asp His Asn Ser Lys Thr Thr Thr 
            420                 425                 430         


Trp Ser Lys Pro Thr Met Gln Asp Asp Pro Arg Ser Lys Ile Pro Ala 
        435                 440                 445             


His Leu Arg Gly Lys Thr Asp Ser Asn Asp Leu Gly Pro Leu Pro Pro 
    450                 455                 460                 


Gly Trp Glu Glu Arg Thr His Thr Asp Gly Arg Val Phe Phe Ile Asn 
465                 470                 475                 480 


His Asn Ile Lys Lys Thr Gln Trp Glu Asp Pro Arg Leu Gln Asn Val 
                485                 490                 495     


Ala Ile Thr Gly Pro Ala Val Pro Tyr Ser Arg Asp Tyr Lys Arg Lys 
            500                 505                 510         


Tyr Glu Phe Phe Arg Arg Lys Leu Lys Lys Gln Thr Asp Ile Pro Asn 
        515                 520                 525             


Lys Phe Glu Met Lys Leu Arg Arg Ala Asn Ile Leu Glu Asp Ser Tyr 
    530                 535                 540                 


Arg Arg Ile Met Gly Val Lys Arg Ala Asp Leu Leu Lys Ala Arg Leu 
545                 550                 555                 560 


Trp Ile Glu Phe Asp Gly Glu Lys Gly Leu Asp Tyr Gly Gly Val Ala 
                565                 570                 575     


Arg Glu Trp Phe Phe Leu Ile Ser Lys Glu Met Phe Asn Pro Tyr Tyr 
            580                 585                 590         


Gly Leu Phe Glu Tyr Ser Ala Thr Asp Asn Tyr Thr Leu Gln Ile Asn 
        595                 600                 605             


Pro Asn Ser Gly Leu Cys Asn Glu Asp His Leu Ser Tyr Phe Lys Phe 
    610                 615                 620                 


Ile Gly Arg Val Ala Gly Met Ala Val Tyr His Gly Lys Leu Leu Asp 
625                 630                 635                 640 


Gly Phe Phe Ile Arg Pro Phe Tyr Lys Met Met Leu Gln Lys Leu Ile 
                645                 650                 655     


Thr Leu His Asp Met Glu Ser Val Asp Ser Glu Tyr Tyr Ser Ser Leu 
            660                 665                 670         


Arg Trp Ile Leu Glu Asn Asp Pro Thr Glu Leu Asp Leu Arg Phe Ile 
        675                 680                 685             


Ile Asp Glu Glu Leu Phe Gly Gln Thr His Gln His Glu Leu Lys Thr 
    690                 695                 700                 


Gly Gly Ser Glu Ile Val Val Thr Asn Lys Asn Lys Lys Glu Tyr Ile 
705                 710                 715                 720 


Tyr Leu Val Ile Gln Trp Arg Phe Val Asn Arg Ile Gln Lys Gln Met 
                725                 730                 735     


Ala Ala Phe Lys Glu Gly Phe Phe Glu Leu Ile Pro Gln Asp Leu Ile 
            740                 745                 750         


Lys Ile Phe Asp Glu Asn Glu Leu Glu Leu Leu Met Cys Gly Leu Gly 
        755                 760                 765             


Asp Val Asp Val Asn Asp Trp Arg Glu His Thr Lys Tyr Lys Asn Gly 
    770                 775                 780                 


Tyr Ser Met Asn His Gln Val Ile His Trp Phe Trp Lys Ala Val Trp 
785                 790                 795                 800 


Met Met Asp Ser Glu Lys Arg Ile Arg Leu Leu Gln Phe Val Thr Gly 
                805                 810                 815     


Thr Ser Arg Val Pro Met Asn Gly Phe Ala Glu Leu Tyr Gly Ser Asn 
            820                 825                 830         


Gly Pro Gln Ser Phe Thr Val Glu Gln Trp Gly Thr Pro Asp Lys Leu 
        835                 840                 845             


Pro Arg Ala His Thr Cys Phe Asn Arg Leu Asp Leu Pro Pro Tyr Glu 
    850                 855                 860                 


Ser Phe Asp Glu Leu Trp Asp Lys Leu Gln Met Ala Ile Glu Asn Thr 
865                 870                 875                 880 


Gln Gly Phe Asp Gly Val Asp 
                885         


<210>  38
<211>  536
<212>  PRT
<213>  Mus musculus

<400>  38

Met Leu Val Leu Phe Glu Thr Ser Val Gly Tyr Ala Ile Phe Lys Val 
1               5                   10                  15      


Leu Asn Glu Lys Lys Leu Gln Glu Val Asp Ser Leu Trp Lys Glu Phe 
            20                  25                  30          


Glu Thr Pro Glu Lys Ala Asn Lys Ile Val Lys Leu Lys His Phe Glu 
        35                  40                  45              


Lys Phe Gln Asp Thr Ala Glu Ala Leu Ala Ala Phe Thr Ala Leu Met 
    50                  55                  60                  


Glu Gly Lys Ile Asn Lys Gln Leu Lys Lys Val Leu Lys Lys Ile Val 
65                  70                  75                  80  


Lys Glu Ala His Glu Pro Leu Ala Val Ala Asp Ala Lys Leu Gly Gly 
                85                  90                  95      


Val Ile Lys Glu Lys Leu Asn Leu Ser Cys Ile His Ser Pro Val Val 
            100                 105                 110         


Asn Glu Leu Met Arg Gly Ile Arg Ser Gln Met Asp Gly Leu Ile Pro 
        115                 120                 125             


Gly Val Glu Pro Arg Glu Met Ala Ala Met Cys Leu Gly Leu Ala His 
    130                 135                 140                 


Ser Leu Ser Arg Tyr Arg Leu Lys Phe Ser Ala Asp Lys Val Asp Thr 
145                 150                 155                 160 


Met Ile Val Gln Ala Ile Ser Leu Leu Asp Asp Leu Asp Lys Glu Leu 
                165                 170                 175     


Asn Asn Tyr Ile Met Arg Cys Arg Glu Trp Tyr Gly Trp His Phe Pro 
            180                 185                 190         


Glu Leu Gly Lys Ile Ile Ser Asp Asn Leu Thr Tyr Cys Lys Cys Leu 
        195                 200                 205             


Gln Lys Val Gly Asp Arg Lys Asn Tyr Ala Ser Ala Ser Leu Ser Glu 
    210                 215                 220                 


Phe Leu Ser Glu Glu Val Glu Ala Glu Val Lys Ala Ala Ala Glu Ile 
225                 230                 235                 240 


Ser Met Gly Thr Glu Val Ser Glu Glu Asp Ile Cys Asn Ile Leu His 
                245                 250                 255     


Leu Cys Thr Gln Val Ile Glu Ile Ser Glu Tyr Arg Thr Gln Leu Tyr 
            260                 265                 270         


Glu Tyr Leu Gln Asn Arg Met Met Ala Ile Ala Pro Asn Val Thr Val 
        275                 280                 285             


Met Val Gly Glu Leu Val Gly Ala Arg Leu Ile Ala His Ala Gly Ser 
    290                 295                 300                 


Leu Leu Asn Leu Ala Lys His Ala Ala Ser Thr Val Gln Ile Leu Gly 
305                 310                 315                 320 


Ala Glu Lys Ala Leu Phe Arg Ala Leu Lys Ser Arg Arg Asp Thr Pro 
                325                 330                 335     


Lys Tyr Gly Leu Ile Tyr His Ala Ser Leu Val Gly Gln Ser Ser Pro 
            340                 345                 350         


Lys His Lys Gly Lys Ile Ser Arg Met Leu Ala Ala Lys Thr Val Leu 
        355                 360                 365             


Ala Ile Arg Tyr Asp Ala Phe Gly Glu Asp Ser Ser Ser Ala Met Gly 
    370                 375                 380                 


Ile Glu Asn Arg Ala Lys Leu Glu Ala Arg Leu Arg Ile Leu Glu Asp 
385                 390                 395                 400 


Arg Gly Ile Arg Lys Ile Ser Gly Thr Gly Lys Ala Leu Ala Lys Ala 
                405                 410                 415     


Glu Lys Tyr Glu His Lys Ser Glu Val Lys Thr Tyr Asp Pro Ser Gly 
            420                 425                 430         


Asp Ser Thr Leu Pro Thr Cys Ser Lys Lys Arg Lys Ile Glu Glu Val 
        435                 440                 445             


Asp Lys Glu Asp Glu Ile Thr Glu Lys Lys Ala Lys Lys Ala Lys Ile 
    450                 455                 460                 


Lys Ile Lys Ala Glu Val Glu Glu Glu Met Glu Glu Glu Glu Ala Glu 
465                 470                 475                 480 


Glu Glu Gln Val Val Glu Glu Glu Pro Thr Val Lys Lys Lys Lys Lys 
                485                 490                 495     


Lys Asp Lys Lys Lys His Ile Lys Glu Glu Pro Leu Ser Glu Glu Glu 
            500                 505                 510         


Pro Cys Thr Ser Thr Ala Val Pro Ser Pro Glu Lys Lys Lys Lys Lys 
        515                 520                 525             


Lys Lys Lys Lys Asp Ala Glu Asp 
    530                 535     


<210>  39
<211>  754
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  39

Xaa Asn Cys Thr Lys Leu Thr Arg Lys Met Ala Gln Gln Thr Thr Ser 
1               5                   10                  15      


Pro Asp Thr Leu Thr Val Pro Glu Val Asp Asn Pro His Val Pro Asn 
            20                  25                  30          


Pro Trp Leu Asn Glu Asp Leu Val Lys Ser Leu Arg Glu Asn Leu Leu 
        35                  40                  45              


Gln His Glu Lys Ser Lys Thr Ala Arg Lys Ser Val Ser Pro Lys Leu 
    50                  55                  60                  


Ser Pro Val Ile Ser Pro Arg Asn Ser Pro Arg Leu Leu Arg Arg Met 
65                  70                  75                  80  


Leu Leu Ser Ser Asn Ile Pro Lys Gln Arg Arg Phe Thr Val Ala His 
                85                  90                  95      


Thr Cys Phe Asp Val Asp Asn Gly Thr Ser Ala Gly Arg Ser Pro Leu 
            100                 105                 110         


Asp Pro Met Thr Ser Pro Gly Ser Gly Leu Ile Leu Gln Ala Asn Phe 
        115                 120                 125             


Val His Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp 
    130                 135                 140                 


Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg Asn Ser Ser Ile Ala Ser 
145                 150                 155                 160 


Asp Ile His Gly Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu 
                165                 170                 175     


Ala Ser Leu Arg Thr Val Arg Asn Asn Phe Ala Ala Leu Thr Asn Leu 
            180                 185                 190         


Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro Met Cys Asn Gln Pro Ser 
        195                 200                 205             


Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala Tyr Gln Lys Leu Ala Ser 
    210                 215                 220                 


Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu 
225                 230                 235                 240 


Gln Thr Arg His Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg 
                245                 250                 255     


Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly 
            260                 265                 270         


Asn Gln Val Ser Glu Tyr Ile Ser Asn Thr Phe Leu Asp Lys Gln His 
        275                 280                 285             


Glu Val Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys Glu Lys Lys Lys 
    290                 295                 300                 


Arg Pro Met Ser Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser 
305                 310                 315                 320 


Ser Leu Thr Asn Ser Cys Ile Pro Arg Phe Gly Val Lys Thr Glu Gln 
                325                 330                 335     


Glu Asp Val Leu Ala Lys Glu Leu Glu Asp Val Asn Lys Trp Gly Leu 
            340                 345                 350         


His Val Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Val 
        355                 360                 365             


Ile Met His Thr Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Lys 
    370                 375                 380                 


Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu Met Thr Leu Glu Asp His 
385                 390                 395                 400 


Tyr His Ala Asp Val Ala Tyr His Asn Asn Ile His Ala Ala Asp Val 
                405                 410                 415     


Val Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu Glu Ala Val 
            420                 425                 430         


Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ser Ala Ile His 
        435                 440                 445             


Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn 
    450                 455                 460                 


Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser Ser Val Leu Glu Asn His 
465                 470                 475                 480 


His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu Asn Cys Asp Ile 
                485                 490                 495     


Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu Arg Lys Met Val 
            500                 505                 510         


Ile Asp Ile Val Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu 
        515                 520                 525             


Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly 
    530                 535                 540                 


Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn 
545                 550                 555                 560 


Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Gln Leu 
                565                 570                 575     


Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe Arg Gln Gly 
            580                 585                 590         


Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys 
        595                 600                 605             


His Asn Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile 
    610                 615                 620                 


Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala 
625                 630                 635                 640 


Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser 
                645                 650                 655     


Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp Gln Glu Glu Gly 
            660                 665                 670         


Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu 
        675                 680                 685             


Asp Cys Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser Gln Val Glu Glu 
    690                 695                 700                 


Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr Gln Asp Ser Glu 
705                 710                 715                 720 


Ser Thr Glu Ile Pro Leu Asp Glu Gln Val Glu Glu Glu Ala Val Ala 
                725                 730                 735     


Glu Glu Glu Ser Gln Pro Glu Thr Cys Val Pro Asp Asp Cys Cys Pro 
            740                 745                 750         


Asp Thr 
        


<210>  40
<211>  154
<212>  PRT
<213>  Mus musculus

<400>  40

Met Ala Asp Ser Ser Gly Arg Val Gly Lys Ser Gly Gly Ser Gly Ala 
1               5                   10                  15      


Gly Lys Gly Ala Val Ser Ala Glu Gln Val Ile Ala Gly Phe Asn Arg 
            20                  25                  30          


Leu Arg Gln Glu Gln Arg Gly Leu Ala Ser Lys Ala Ala Glu Leu Glu 
        35                  40                  45              


Met Glu Leu Asn Glu His Ser Leu Val Ile Asp Thr Leu Lys Glu Val 
    50                  55                  60                  


Asp Glu Thr Arg Lys Cys Tyr Arg Met Val Gly Gly Val Leu Val Glu 
65                  70                  75                  80  


Arg Thr Val Lys Glu Val Leu Pro Ala Leu Glu Gly Asn Lys Glu Gln 
                85                  90                  95      


Ile Gln Lys Ile Ile Glu Thr Leu Ser Gln Gln Leu Gln Ala Lys Gly 
            100                 105                 110         


Lys Glu Leu Asn Glu Phe Arg Glu Lys His Asn Ile Arg Leu Met Gly 
        115                 120                 125             


Glu Asp Glu Lys Pro Ala Ala Lys Glu Asn Ser Glu Gly Ala Gly Ala 
    130                 135                 140                 


Lys Ala Ser Ser Ala Gly Val Leu Val Ser 
145                 150                 


<210>  41
<211>  885
<212>  PRT
<213>  Mus musculus

<400>  41

Met Glu Thr Glu Pro Val Ser Val Gln Lys Val Pro Ala Pro Pro Gly 
1               5                   10                  15      


Ser Pro Cys Arg Gln Gln Asp Ser Ala Leu Thr Pro Thr Pro Thr Met 
            20                  25                  30          


Pro Pro Pro Glu Glu Pro Ser Glu Asp Tyr Glu His Ser Gln Ser Pro 
        35                  40                  45              


Ala Glu Gln Ala Ile Gln Glu Glu Phe Gln Phe Leu Arg Cys Pro Ser 
    50                  55                  60                  


Cys Gln Ala Gln Ala Lys Cys Pro Lys Leu Leu Pro Cys Leu His Thr 
65                  70                  75                  80  


Leu Cys Ser Gly Cys Leu Glu Ala Pro Gly Leu Gln Cys Pro Ile Cys 
                85                  90                  95      


Lys Ala Pro Gly Gln Ala Asp Ala Asn Gly Glu Ala Leu Asp Asn Val 
            100                 105                 110         


Phe Phe Glu Ser Leu Gln Arg Arg Leu Ala Val Phe Arg Gln Ile Val 
        115                 120                 125             


Asp Ala Gln Ala Ala Cys Thr Arg Cys Lys Gly Leu Ala Asp Phe Trp 
    130                 135                 140                 


Cys Phe Glu Cys Glu Gln Leu Ile Cys Ser Lys Cys Phe Glu Ala His 
145                 150                 155                 160 


Gln Trp Tyr Leu Lys His Glu Ala Arg Pro Leu Ala Asp Leu Arg Asp 
                165                 170                 175     


Asn Ser Val Ser Ser Phe Leu Asp Ser Thr Arg Lys Ser Asn Ile Phe 
            180                 185                 190         


Cys Ser Asn Thr Asn His Arg Asn Pro Ala Leu Thr Asp Ile Tyr Cys 
        195                 200                 205             


Arg Gly Cys Ala Lys Pro Leu Cys Cys Thr Cys Ala Leu Leu Asp Arg 
    210                 215                 220                 


Asn His Ser His Leu His Cys Asp Ile Gly Glu Glu Ile Gln Gln Trp 
225                 230                 235                 240 


His Glu Glu Leu Gly Thr Met Thr Gln Thr Leu Glu Glu Gln Gly Arg 
                245                 250                 255     


Thr Phe Asp Ser Ala His Ala Gln Met Cys Ser Ala Ile Gly Gln Leu 
            260                 265                 270         


Asp His Ala Arg Ala Asp Ile Glu Lys Gln Ile Arg Ala Arg Val Arg 
        275                 280                 285             


Gln Val Val Asp Tyr Val Gln Ala Gln Glu Arg Glu Leu Leu Glu Ala 
    290                 295                 300                 


Val Asn Asp Arg Tyr Gln Arg Asp Tyr Gln Glu Ile Ala Gly Gln Leu 
305                 310                 315                 320 


Ser Cys Leu Glu Ala Val Leu Gln Arg Ile Arg Thr Ser Gly Ala Leu 
                325                 330                 335     


Val Lys Arg Met Lys Leu Tyr Ala Ser Asp Gln Glu Val Leu Asp Met 
            340                 345                 350         


His Ser Phe Leu Arg Lys Ala Leu Cys Ser Leu Arg Gln Glu Glu Pro 
        355                 360                 365             


Gln Asn Gln Lys Val Gln Leu Leu Thr Arg Gly Phe Glu Glu Phe Lys 
    370                 375                 380                 


Leu Cys Leu Gln Asp Phe Ile Ser Cys Ile Thr Gln Arg Ile Asn Ala 
385                 390                 395                 400 


Ala Val Ala Ser Pro Glu Ala Ala Ser Asn Gln Pro Glu Ala Ala Ser 
                405                 410                 415     


Thr His Pro Val Thr Thr Ser Thr Pro Glu Asp Leu Glu Gln Pro Lys 
            420                 425                 430         


Glu Val Gln Ser Val Gln Ala Gln Ala Leu Glu Leu Ser Lys Thr Gln 
        435                 440                 445             


Pro Val Ala Met Val Lys Thr Val Pro Gly Ala His Pro Val Pro Val 
    450                 455                 460                 


Tyr Ala Phe Ser Met Gln Gly Pro Thr Tyr Arg Glu Glu Ala Ser Gln 
465                 470                 475                 480 


Thr Val Gly Ser Met Lys Arg Lys Cys Ser His Glu Asp Cys Ser Arg 
                485                 490                 495     


Lys Ile Ile Lys Met Glu Ser Thr Glu Glu Asn Glu Asp Arg Leu Ala 
            500                 505                 510         


Thr Ser Ser Pro Glu Gln Ser Trp Pro Ser Thr Phe Lys Ala Thr Ser 
        515                 520                 525             


Pro Pro His Leu Asp Gly Thr Ser Asn Pro Glu Ser Thr Val Pro Glu 
    530                 535                 540                 


Lys Lys Ile Leu Leu Pro Asn Asn Asn His Val Thr Ser Asp Thr Gly 
545                 550                 555                 560 


Glu Thr Glu Glu Arg Val Val Val Ile Ser Ser Ser Glu Asp Ser Asp 
                565                 570                 575     


Thr Glu Asn Leu Ser Ser His Glu Leu Asp Asp Ser Ser Ser Glu Ser 
            580                 585                 590         


Ser Ser Leu Gln Leu Glu Gly Pro Asn Ser Leu Lys Ala Leu Asp Glu 
        595                 600                 605             


Ser Leu Ala Glu Pro His Leu Glu Asp Arg Thr Leu Val Phe Phe Asp 
    610                 615                 620                 


Leu Lys Ile Asp Asn Glu Thr Gln Lys Ile Ser Gln Leu Ala Ala Val 
625                 630                 635                 640 


Asn Arg Glu Ser Lys Phe Arg Val Leu Ile Gln Pro Glu Ala Phe Ser 
                645                 650                 655     


Val Tyr Ser Lys Ala Val Ser Leu Glu Ala Gly Leu Arg His Phe Leu 
            660                 665                 670         


Ser Phe Leu Thr Thr Met His Arg Pro Ile Leu Ala Cys Ser Arg Leu 
        675                 680                 685             


Trp Gly Pro Gly Leu Pro Ile Phe Phe Gln Thr Leu Ser Asp Ile Asn 
    690                 695                 700                 


Lys Leu Trp Glu Phe Gln Asp Thr Ile Ser Gly Phe Leu Ala Val Leu 
705                 710                 715                 720 


Pro Leu Ile Arg Glu Arg Ile Pro Gly Ala Ser Ser Phe Lys Leu Gly 
                725                 730                 735     


Asn Leu Ala Lys Thr Tyr Leu Ala Arg Asn Met Ser Glu Arg Ser Ala 
            740                 745                 750         


Leu Ala Ser Val Leu Ala Met Arg Asp Leu Cys Cys Leu Leu Glu Ile 
        755                 760                 765             


Ser Pro Gly Leu Pro Leu Ala Gln His Ile Tyr Ser Phe Ser Ser Leu 
    770                 775                 780                 


Gln Cys Phe Ala Ser Leu Gln Pro Leu Ile Gln Ala Ser Val Leu Pro 
785                 790                 795                 800 


Gln Ser Glu Ala Arg Leu Leu Ala Leu His Asn Val Ser Phe Val Glu 
                805                 810                 815     


Leu Leu Asn Ala Tyr Arg Thr Asn Arg Gln Glu Gly Leu Lys Lys Tyr 
            820                 825                 830         


Val His Tyr Leu Ser Leu Gln Thr Thr Pro Leu Ser Ser Ser Ala Ser 
        835                 840                 845             


Thr Gln Val Ala Gln Phe Leu Gln Ala Leu Ser Thr His Met Glu Gly 
    850                 855                 860                 


Leu Leu Glu Gly His Ala Pro Ala Gly Ala Glu Gly Lys Ala Glu Ser 
865                 870                 875                 880 


Lys Gly Cys Leu Ala 
                885 


<210>  42
<211>  542
<212>  PRT
<213>  Mus musculus

<400>  42

Met Gly Ala Tyr Leu Ser Gln Pro Asn Thr Val Lys Cys Ser Gly Asp 
1               5                   10                  15      


Gly Val Gly Ala Pro Arg Leu Pro Leu Pro Tyr Gly Phe Ser Ala Met 
            20                  25                  30          


Gln Gly Trp Arg Val Ser Met Glu Asp Ala His Asn Cys Ile Pro Glu 
        35                  40                  45              


Leu Asp Asn Glu Thr Ala Met Phe Ser Val Tyr Asp Gly His Gly Gly 
    50                  55                  60                  


Glu Glu Val Ala Leu Tyr Cys Ala Lys Tyr Leu Pro Asp Ile Ile Lys 
65                  70                  75                  80  


Asp Gln Lys Ala Tyr Lys Glu Gly Lys Leu Gln Lys Ala Leu Gln Asp 
                85                  90                  95      


Ala Phe Leu Ala Ile Asp Ala Lys Leu Thr Thr Glu Glu Val Ile Lys 
            100                 105                 110         


Glu Leu Ala Gln Ile Ala Gly Arg Pro Thr Glu Asp Glu Asp Asp Lys 
        115                 120                 125             


Asp Lys Val Ala Asp Glu Asp Asp Val Asp Asn Glu Glu Ala Ala Leu 
    130                 135                 140                 


Leu His Glu Glu Ala Thr Met Thr Ile Glu Glu Leu Leu Thr Arg Tyr 
145                 150                 155                 160 


Gly Gln Asn Cys Gln Lys Val Pro Pro His Thr Lys Ser Gly Ile Gly 
                165                 170                 175     


Thr Gly Asp Glu Pro Gly Pro Gln Gly Leu Asn Gly Glu Ala Gly Pro 
            180                 185                 190         


Glu Asp Pro Ser Arg Glu Thr Pro Ser Gln Glu Asn Gly Pro Thr Ala 
        195                 200                 205             


Lys Gly His Thr Gly Phe Ser Ser Asn Ser Glu His Gly Thr Glu Ala 
    210                 215                 220                 


Gly Gln Ile Ser Glu Pro Gly Thr Ala Thr Gly Glu Ala Gly Pro Ser 
225                 230                 235                 240 


Cys Ser Ser Ala Ser Asp Lys Leu Pro Arg Val Ala Lys Ser Lys Phe 
                245                 250                 255     


Phe Glu Asp Ser Glu Asp Glu Ser Asp Glu Val Glu Glu Glu Glu Asp 
            260                 265                 270         


Asp Ser Glu Glu Cys Ser Glu Asp Glu Asp Gly Tyr Ser Ser Glu Glu 
        275                 280                 285             


Ala Glu Asn Glu Glu Asp Glu Asp Asp Thr Glu Glu Ala Glu Glu Asp 
    290                 295                 300                 


Asp Asp Glu Glu Met Met Val Pro Gly Met Glu Gly Lys Glu Glu Pro 
305                 310                 315                 320 


Gly Ser Asp Ser Gly Thr Thr Ala Val Val Ala Leu Ile Arg Gly Lys 
                325                 330                 335     


Gln Leu Ile Val Ala Asn Ala Gly Asp Ser Arg Cys Val Val Ser Glu 
            340                 345                 350         


Ala Gly Lys Ala Leu Asp Met Ser Tyr Asp His Lys Pro Glu Asp Glu 
        355                 360                 365             


Val Glu Leu Ala Arg Ile Lys Asn Ala Gly Gly Lys Val Thr Met Asp 
    370                 375                 380                 


Gly Arg Val Asn Gly Gly Leu Asn Leu Ser Arg Ala Ile Gly Asp His 
385                 390                 395                 400 


Phe Tyr Lys Arg Asn Lys Asn Leu Pro Pro Gln Glu Gln Met Ile Ser 
                405                 410                 415     


Ala Leu Pro Asp Ile Lys Val Leu Thr Leu Thr Asp Asp His Glu Phe 
            420                 425                 430         


Met Val Ile Ala Cys Asp Gly Ile Trp Asn Val Met Ser Ser Gln Glu 
        435                 440                 445             


Val Val Asp Phe Ile Gln Ser Lys Ile Ser Gln Arg Asp Glu Asn Gly 
    450                 455                 460                 


Glu Leu Arg Leu Leu Ser Ser Ile Val Glu Glu Leu Leu Asp Gln Cys 
465                 470                 475                 480 


Leu Ala Pro Asp Thr Ser Gly Asp Gly Thr Gly Cys Asp Asn Met Thr 
                485                 490                 495     


Cys Ile Ile Ile Cys Phe Lys Pro Arg Asn Thr Val Glu Leu Gln Ala 
            500                 505                 510         


Glu Ser Gly Lys Arg Lys Leu Glu Glu Ala Leu Ser Thr Glu Gly Ala 
        515                 520                 525             


Glu Asp Thr Gly Asn Ser Asp Lys Lys Lys Ala Lys Arg Asp 
    530                 535                 540         


<210>  43
<211>  589
<212>  PRT
<213>  Mus musculus

<400>  43

Met Ala Ala Ala Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu 
1               5                   10                  15      


Ile Asp Glu Leu Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile 
            20                  25                  30          


Lys Lys Leu Ser Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg 
        35                  40                  45              


Ser Glu Leu Leu Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu 
    50                  55                  60                  


Val Leu Leu Ala Leu Ala Glu Gln Leu Gly Thr Phe Thr Thr Leu Val 
65                  70                  75                  80  


Gly Gly Pro Glu Tyr Val His Cys Leu Leu Pro Pro Leu Glu Ser Leu 
                85                  90                  95      


Ala Thr Val Glu Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu 
            100                 105                 110         


Arg Ala Ile Ser His Glu His Ser Pro Ser Asp Leu Glu Ala His Phe 
        115                 120                 125             


Val Pro Leu Val Lys Arg Leu Ala Gly Gly Asp Trp Phe Thr Ser Arg 
    130                 135                 140                 


Thr Ser Ala Cys Gly Leu Phe Ser Val Cys Tyr Pro Arg Val Ser Ser 
145                 150                 155                 160 


Ala Val Lys Ala Glu Leu Arg Gln Tyr Phe Arg Asn Leu Cys Ser Asp 
                165                 170                 175     


Asp Thr Pro Met Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe 
            180                 185                 190         


Ala Lys Val Leu Glu Leu Asp Asn Val Lys Ser Glu Ile Ile Pro Met 
        195                 200                 205             


Phe Ser Asn Leu Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala 
    210                 215                 220                 


Val Glu Ala Cys Val Asn Ile Ala Gln Leu Leu Pro Gln Glu Asp Leu 
225                 230                 235                 240 


Glu Ala Leu Val Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser 
                245                 250                 255     


Trp Arg Val Arg Tyr Met Val Ala Asp Lys Phe Thr Glu Leu Gln Lys 
            260                 265                 270         


Ala Val Gly Pro Glu Ile Thr Lys Thr Asp Leu Val Pro Ala Phe Gln 
        275                 280                 285             


Asn Leu Met Lys Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ser His 
    290                 295                 300                 


Lys Val Lys Glu Phe Cys Glu Asn Leu Ser Ala Asp Cys Arg Glu Asn 
305                 310                 315                 320 


Val Ile Met Thr Gln Ile Leu Pro Cys Ile Lys Glu Leu Val Ser Asp 
                325                 330                 335     


Ala Asn Gln His Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu 
            340                 345                 350         


Ser Pro Ile Leu Gly Lys Asp Asn Thr Ile Glu His Leu Leu Pro Leu 
        355                 360                 365             


Phe Leu Ala Gln Leu Lys Asp Glu Cys Pro Glu Val Arg Leu Asn Ile 
    370                 375                 380                 


Ile Ser Asn Leu Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu 
385                 390                 395                 400 


Ser Gln Ser Leu Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys 
                405                 410                 415     


Trp Arg Val Arg Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly 
            420                 425                 430         


Gln Leu Gly Val Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met 
        435                 440                 445             


Ala Trp Leu Val Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Ser 
    450                 455                 460                 


Asn Leu Lys Lys Leu Val Glu Lys Phe Gly Lys Glu Trp Ala His Ala 
465                 470                 475                 480 


Thr Ile Ile Pro Lys Val Leu Ala Met Ser Gly Asp Pro Asn Tyr Leu 
                485                 490                 495     


His Arg Met Thr Thr Leu Phe Cys Ile Asn Val Leu Ser Glu Val Cys 
            500                 505                 510         


Gly Gln Asp Ile Thr Thr Lys His Met Leu Pro Thr Val Leu Arg Met 
        515                 520                 525             


Ala Gly Asp Pro Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu 
    530                 535                 540                 


Gln Lys Ile Gly Pro Ile Leu Asp Asn Ser Thr Leu Gln Ser Glu Val 
545                 550                 555                 560 


Lys Pro Ile Leu Glu Lys Leu Thr Gln Asp Gln Asp Val Asp Val Lys 
                565                 570                 575     


Tyr Phe Ala Gln Glu Ala Leu Thr Val Leu Ser Leu Ala 
            580                 585                 


<210>  44
<211>  447
<212>  PRT
<213>  Mus musculus

<400>  44

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
1               5                   10                  15      


Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
            20                  25                  30          


Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
        35                  40                  45              


Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
    50                  55                  60                  


Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
65                  70                  75                  80  


Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                85                  90                  95      


Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
            100                 105                 110         


Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
        115                 120                 125             


Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
    130                 135                 140                 


Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
145                 150                 155                 160 


Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                165                 170                 175     


Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
            180                 185                 190         


Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
        195                 200                 205             


Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
    210                 215                 220                 


Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
225                 230                 235                 240 


Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                245                 250                 255     


Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
            260                 265                 270         


Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
        275                 280                 285             


Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
    290                 295                 300                 


Tyr Leu Ser Val Lys Ile Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
305                 310                 315                 320 


Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                325                 330                 335     


Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
            340                 345                 350         


Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
        355                 360                 365             


Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
    370                 375                 380                 


Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
385                 390                 395                 400 


Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                405                 410                 415     


Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
            420                 425                 430         


Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
        435                 440                 445         


<210>  45
<211>  199
<212>  PRT
<213>  Mus musculus

<400>  45

Met Ser Ser Gly Asn Ala Lys Ile Gly Tyr Pro Ala Pro Asn Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser 
            20                  25                  30          


Glu Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe 
        35                  40                  45              


Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Asp 
    50                  55                  60                  


Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser 
65                  70                  75                  80  


His Phe Cys His Leu Ala Trp Ile Asn Thr Pro Lys Lys Gln Gly Gly 
                85                  90                  95      


Leu Gly Pro Met Asn Ile Pro Leu Ile Ser Asp Pro Lys Arg Thr Ile 
            100                 105                 110         


Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg 
        115                 120                 125             


Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Ile 
    130                 135                 140                 


Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Ile Ile Arg Leu Val 
145                 150                 155                 160 


Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly 
                165                 170                 175     


Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Asn Lys Ser Lys 
            180                 185                 190         


Glu Tyr Phe Ser Lys Gln Lys 
        195                 


<210>  46
<211>  274
<212>  PRT
<213>  Mus musculus

<400>  46

Met Glu Ala Arg Ser Lys Leu Leu Asp Gly Thr Thr Ala Ser Arg Arg 
1               5                   10                  15      


Trp Thr Arg Lys Leu Val Leu Leu Leu Pro Pro Leu Leu Leu Phe Leu 
            20                  25                  30          


Leu Arg Thr Glu Ser Leu Gln Gly Leu Glu Ser Asp Glu Arg Phe Arg 
        35                  40                  45              


Thr Arg Glu Asn Glu Cys His Phe Tyr Ala Gly Gly Gln Val Tyr Pro 
    50                  55                  60                  


Gly Glu Ala Ser Arg Val Ser Val Ala Asp His Ser Leu His Leu Ser 
65                  70                  75                  80  


Lys Ala Lys Ile Ser Lys Pro Ala Pro Tyr Trp Glu Gly Thr Ala Val 
                85                  90                  95      


Ile Asn Gly Glu Phe Lys Glu Leu Lys Leu Thr Asp Tyr Arg Gly Lys 
            100                 105                 110         


Tyr Leu Val Phe Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro 
        115                 120                 125             


Thr Glu Ile Ile Ala Phe Gly Asp Arg Ile Glu Glu Phe Lys Ser Ile 
    130                 135                 140                 


Asn Thr Glu Val Val Ala Cys Ser Val Asp Ser Gln Phe Thr His Leu 
145                 150                 155                 160 


Ala Trp Ile Asn Thr Pro Arg Arg Gln Gly Gly Leu Gly Pro Ile Arg 
                165                 170                 175     


Ile Pro Leu Leu Ser Asp Leu Asn His Gln Ile Ser Lys Asp Tyr Gly 
            180                 185                 190         


Val Tyr Leu Glu Asp Ser Gly His Thr Leu Arg Gly Leu Phe Ile Ile 
        195                 200                 205             


Asp Asp Lys Gly Val Leu Arg Gln Ile Thr Leu Asn Asp Leu Pro Val 
    210                 215                 220                 


Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val Gln Ala Phe Gln Tyr 
225                 230                 235                 240 


Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Ser 
                245                 250                 255     


Glu Thr Ile Ile Pro Asp Pro Ala Gly Lys Leu Lys Tyr Phe Asp Lys 
            260                 265                 270         


Leu Asn 
        


<210>  47
<211>  520
<212>  PRT
<213>  Mus musculus

<400>  47

Met Pro Arg Lys Lys Gly Ala Ala Trp Glu Glu Pro Ser Ser Gly Asn 
1               5                   10                  15      


Gly Thr Ala Arg Ala Gly Pro Arg Arg Arg Gly Gly Pro Ala Gly Arg 
            20                  25                  30          


Lys Arg Glu Arg Pro Glu Arg Cys Ser Ser Ser Ser Gly Gly Gly Ser 
        35                  40                  45              


Ser Gly Asp Glu Asp Gly Pro Glu Leu Asp Gly Ala Pro Gly Gly Gly 
    50                  55                  60                  


Lys Arg Thr Ala Arg Pro Ala Thr Ala Gly Lys Ala Ala Gly Ala Ala 
65                  70                  75                  80  


Ala Ile Ile Thr Glu Pro Glu His Thr Lys Glu Arg Val Lys Leu Glu 
                85                  90                  95      


Gly Ser Lys Cys Lys Gly Gln Leu Leu Ile Phe Gly Ala Thr Asn Trp 
            100                 105                 110         


Asp Leu Ile Gly Arg Lys Glu Val Pro Lys Gln Gln Ala Ala Tyr Arg 
        115                 120                 125             


Asn Leu Gly Gln Asn Leu Trp Gly Pro His Arg Tyr Gly Cys Leu Ser 
    130                 135                 140                 


Gly Val Arg Val Arg Thr Val Val Ser Gly Ser Cys Ala Ala His Ser 
145                 150                 155                 160 


Leu Leu Ile Thr Thr Glu Gly Lys Leu Trp Ser Trp Gly Arg Asn Glu 
                165                 170                 175     


Lys Gly Gln Leu Gly His Gly Asp Thr Lys Arg Val Glu Ala Pro Arg 
            180                 185                 190         


Leu Ile Glu Ala Leu Ser His Glu Ala Ile Val Leu Ala Ala Cys Gly 
        195                 200                 205             


Arg Asn His Thr Leu Ala Leu Thr Asp Thr Gly Ser Val Phe Ala Phe 
    210                 215                 220                 


Gly Glu Asn Lys Met Gly Gln Leu Gly Leu Gly Asn Gln Thr Asp Ala 
225                 230                 235                 240 


Val Pro Ser Pro Ala Gln Ile Met Tyr Asn Gly Gln Pro Ile Thr Lys 
                245                 250                 255     


Met Ala Cys Gly Ala Glu Phe Ser Met Leu Met Asp Cys Lys Gly Asn 
            260                 265                 270         


Leu Tyr Ser Phe Gly Cys Pro Glu Tyr Gly Gln Leu Gly His Asn Ser 
        275                 280                 285             


Asp Gly Lys Phe Ile Ala Arg Ala Gln Arg Ile Glu Tyr Asp Cys Glu 
    290                 295                 300                 


Leu Val Pro Arg Arg Val Ala Ile Phe Ile Glu Lys Thr Lys Asp Gly 
305                 310                 315                 320 


Gln Ile Leu Pro Val Pro Asn Val Val Val Arg Asp Val Ala Cys Gly 
                325                 330                 335     


Ala Asn His Thr Leu Val Leu Asp Ser Gln Lys Arg Val Phe Ser Trp 
            340                 345                 350         


Gly Phe Gly Gly Tyr Gly Arg Leu Gly His Ala Glu Gln Lys Asp Glu 
        355                 360                 365             


Met Val Pro Arg Leu Val Lys Leu Phe Asp Phe Pro Gly Arg Gly Ala 
    370                 375                 380                 


Thr Gln Ile Tyr Ala Gly Tyr Thr Cys Ser Phe Ala Val Ser Glu Val 
385                 390                 395                 400 


Gly Gly Leu Phe Phe Trp Gly Ala Thr Asn Thr Ser Arg Glu Ser Thr 
                405                 410                 415     


Met Tyr Pro Lys Ala Val Gln Asp Leu Cys Gly Trp Arg Ile Arg Ser 
            420                 425                 430         


Leu Ala Cys Gly Lys Ser Ser Ile Ile Val Ala Ala Asp Glu Ser Thr 
        435                 440                 445             


Ile Ser Trp Gly Pro Ser Pro Thr Phe Gly Glu Leu Gly Tyr Gly Asp 
    450                 455                 460                 


His Lys Pro Lys Ser Ser Thr Ala Ala Gln Glu Val Lys Thr Leu Asp 
465                 470                 475                 480 


Gly Ile Phe Ser Glu Gln Val Ala Met Gly Tyr Ser His Ser Leu Val 
                485                 490                 495     


Ile Ala Arg Asp Glu Ser Glu Ala Glu Lys Glu Lys Leu Gln Arg Leu 
            500                 505                 510         


Pro Glu Tyr Thr Pro Arg Thr Leu 
        515                 520 


<210>  48
<211>  92
<212>  PRT
<213>  Mus musculus

<400>  48

Met Ala Lys Arg Thr Lys Lys Val Gly Ile Val Gly Lys Tyr Gly Thr 
1               5                   10                  15      


Arg Tyr Gly Ala Ser Leu Arg Lys Met Val Lys Lys Ile Glu Ile Ser 
            20                  25                  30          


Gln His Ala Lys Tyr Thr Cys Ser Phe Cys Gly Lys Thr Lys Met Lys 
        35                  40                  45              


Arg Arg Ala Val Gly Ile Trp His Cys Gly Ser Cys Met Lys Thr Val 
    50                  55                  60                  


Ala Gly Gly Ala Trp Thr Tyr Asn Thr Thr Ser Ala Val Thr Val Lys 
65                  70                  75                  80  


Ser Ala Ile Arg Arg Leu Lys Glu Leu Lys Asp Gln 
                85                  90          


<210>  49
<211>  463
<212>  PRT
<213>  Mus musculus

<400>  49

Met Ala Thr Val Ala Ala Thr Thr Lys Val Pro Glu Ile Arg Asp Val 
1               5                   10                  15      


Thr Arg Ile Glu Arg Ile Gly Ala His Ser His Ile Arg Gly Leu Gly 
            20                  25                  30          


Leu Asp Asp Ala Leu Glu Pro Arg Gln Ala Ser Gln Gly Met Val Gly 
        35                  40                  45              


Gln Leu Ala Ala Arg Arg Ala Ala Gly Val Val Leu Glu Met Ile Arg 
    50                  55                  60                  


Glu Gly Lys Ile Ala Gly Arg Ala Val Leu Ile Ala Gly Gln Pro Gly 
65                  70                  75                  80  


Thr Gly Lys Thr Ala Ile Ala Met Gly Met Ala Gln Ala Leu Gly Pro 
                85                  90                  95      


Asp Thr Pro Phe Thr Ala Ile Ala Gly Ser Glu Ile Phe Ser Leu Glu 
            100                 105                 110         


Met Ser Lys Thr Glu Ala Leu Thr Gln Ala Phe Arg Arg Ser Ile Gly 
        115                 120                 125             


Val Arg Ile Lys Glu Glu Thr Glu Ile Ile Glu Gly Glu Val Val Glu 
    130                 135                 140                 


Ile Gln Ile Asp Arg Pro Ala Thr Gly Thr Gly Ser Lys Val Gly Lys 
145                 150                 155                 160 


Leu Thr Leu Lys Thr Thr Glu Met Glu Thr Ile Tyr Asp Leu Gly Thr 
                165                 170                 175     


Lys Met Ile Glu Ser Leu Thr Lys Asp Lys Val Gln Ala Gly Asp Val 
            180                 185                 190         


Ile Thr Ile Asp Lys Ala Thr Gly Lys Ile Ser Lys Leu Gly Arg Ser 
        195                 200                 205             


Phe Thr Arg Ala Arg Asp Tyr Asp Ala Met Gly Ser Gln Thr Lys Phe 
    210                 215                 220                 


Val Gln Cys Pro Asp Gly Glu Leu Gln Lys Arg Lys Glu Val Val His 
225                 230                 235                 240 


Thr Val Ser Leu His Glu Ile Asp Val Ile Asn Ser Arg Thr Gln Gly 
                245                 250                 255     


Phe Leu Ala Leu Phe Ser Gly Asp Thr Gly Glu Ile Lys Ser Glu Val 
            260                 265                 270         


Arg Glu Gln Ile Asn Ala Lys Val Ala Glu Trp Arg Glu Glu Gly Lys 
        275                 280                 285             


Ala Glu Ile Ile Pro Gly Val Leu Phe Ile Asp Glu Val His Met Leu 
    290                 295                 300                 


Asp Ile Glu Ser Phe Ser Phe Leu Asn Arg Ala Leu Glu Ser Asp Met 
305                 310                 315                 320 


Ala Pro Val Leu Ile Met Ala Thr Asn Arg Gly Ile Thr Arg Ile Arg 
                325                 330                 335     


Gly Thr Ser Tyr Gln Ser Pro His Gly Ile Pro Ile Asp Leu Leu Asp 
            340                 345                 350         


Arg Leu Leu Ile Val Ser Thr Ser Pro Tyr Ser Glu Lys Asp Thr Lys 
        355                 360                 365             


Gln Ile Leu Arg Ile Arg Cys Glu Glu Glu Asp Val Glu Met Ser Glu 
    370                 375                 380                 


Asp Ala Tyr Thr Val Leu Thr Arg Ile Gly Leu Glu Thr Ser Leu Arg 
385                 390                 395                 400 


Tyr Ala Ile Gln Leu Ile Thr Ala Ala Ser Leu Val Cys Arg Lys Arg 
                405                 410                 415     


Lys Gly Thr Glu Val Gln Val Asp Asp Ile Lys Arg Val Tyr Ser Leu 
            420                 425                 430         


Phe Leu Asp Glu Ser Arg Ser Thr Gln Tyr Met Lys Glu Tyr Gln Asp 
        435                 440                 445             


Ala Phe Leu Phe Asn Glu Leu Lys Gly Glu Thr Met Asp Thr Ser 
    450                 455                 460             


<210>  50
<211>  360
<212>  PRT
<213>  Mus musculus

<400>  50

Met Phe Val Ala Arg Ser Ile Ala Ala Asp His Lys Asp Leu Ile His 
1               5                   10                  15      


Asp Val Ser Phe Asp Phe His Gly Arg Arg Met Ala Thr Cys Ser Ser 
            20                  25                  30          


Asp Gln Ser Val Lys Val Trp Asp Lys Ser Glu Ser Gly Asp Trp His 
        35                  40                  45              


Cys Thr Ala Ser Trp Lys Thr His Ser Gly Ser Val Trp Arg Val Thr 
    50                  55                  60                  


Trp Ala His Pro Glu Phe Gly Gln Val Leu Ala Ser Cys Ser Phe Asp 
65                  70                  75                  80  


Arg Thr Ala Ala Val Trp Glu Glu Ile Val Gly Glu Ser Asn Asp Lys 
                85                  90                  95      


Leu Arg Gly Gln Ser His Trp Val Lys Arg Thr Thr Leu Val Asp Ser 
            100                 105                 110         


Arg Thr Ser Val Thr Asp Val Lys Phe Ala Pro Lys His Met Gly Leu 
        115                 120                 125             


Met Leu Ala Thr Cys Ser Ala Asp Gly Ile Val Arg Val Tyr Glu Ala 
    130                 135                 140                 


Pro Asp Val Met Asn Leu Ser Gln Trp Ser Leu Gln His Glu Val Ser 
145                 150                 155                 160 


Cys Lys Leu Cys Cys Ser Cys Ile Ser Trp Asn Pro Ser Ser Ser Arg 
                165                 170                 175     


Ala His Pro Pro Met Ile Ala Val Gly Ser Asp Asp Ser Ser Pro Asn 
            180                 185                 190         


Ser Met Ala Lys Val Gln Ile Phe Glu Tyr Asn Glu Asn Thr Arg Lys 
        195                 200                 205             


Tyr Ala Lys Ala Glu Thr Leu Met Thr Val Thr Asp Pro Val His Asp 
    210                 215                 220                 


Ile Ala Phe Ala Pro Asn Leu Gly Arg Ser Phe His Ile Leu Ala Val 
225                 230                 235                 240 


Ala Thr Lys Asp Val Arg Ile Phe Thr Leu Lys Pro Leu Arg Lys Glu 
                245                 250                 255     


Leu Thr Ser Ser Gly Gly Pro Thr Lys Phe Glu Ile His Ile Val Ala 
            260                 265                 270         


Gln Phe Asp Asn His Asn Ser Gln Val Trp Arg Val Ser Trp Asn Ile 
        275                 280                 285             


Thr Gly Thr Val Leu Ala Ser Ser Gly Asp Asp Gly Cys Val Arg Leu 
    290                 295                 300                 


Trp Lys Ala Asn Tyr Met Asp Asn Trp Lys Cys Thr Gly Ile Leu Lys 
305                 310                 315                 320 


Gly Asn Gly Ser Pro Val Asn Gly Ser Ser Gln Leu Gly Asn Ser Asn 
                325                 330                 335     


Pro Ser Leu Ser Ser Asn Ile Pro Asn Leu Gln Asn Ser Leu Asn Gly 
            340                 345                 350         


Thr Ser Ala Ser Arg Lys His Ser 
        355                 360 


<210>  51
<211>  737
<212>  PRT
<213>  Mus musculus

<400>  51

Met Ala Asp Glu Val Ala Leu Ala Leu Gln Ala Ala Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Ala Ala Met Glu Ala Ala Ser Gln Pro Ala Asp Glu Pro Leu 
            20                  25                  30          


Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Gly Arg Ser Pro Gly 
        35                  40                  45              


Glu Pro Ser Ala Ala Val Ala Pro Ala Ala Ala Gly Cys Glu Ala Ala 
    50                  55                  60                  


Ser Ala Ala Ala Pro Ala Ala Leu Trp Arg Glu Ala Ala Gly Ala Ala 
65                  70                  75                  80  


Ala Ser Ala Glu Arg Glu Ala Pro Ala Thr Ala Val Ala Gly Asp Gly 
                85                  90                  95      


Asp Asn Gly Ser Gly Leu Arg Arg Glu Pro Arg Ala Ala Asp Asp Phe 
            100                 105                 110         


Asp Asp Asp Glu Gly Glu Glu Glu Asp Glu Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ile Gly Tyr Arg Asp Asn Leu Leu Leu Thr Asp Gly Leu 
    130                 135                 140                 


Leu Thr Asn Gly Phe His Ser Cys Glu Ser Asp Asp Asp Asp Arg Thr 
145                 150                 155                 160 


Ser His Ala Ser Ser Ser Asp Trp Thr Pro Arg Pro Arg Ile Gly Pro 
                165                 170                 175     


Tyr Thr Phe Val Gln Gln His Leu Met Ile Gly Thr Asp Pro Arg Thr 
            180                 185                 190         


Ile Leu Lys Asp Leu Leu Pro Glu Thr Ile Pro Pro Pro Glu Leu Asp 
        195                 200                 205             


Asp Met Thr Leu Trp Gln Ile Val Ile Asn Ile Leu Ser Glu Pro Pro 
    210                 215                 220                 


Lys Arg Lys Lys Arg Lys Asp Ile Asn Thr Ile Glu Asp Ala Val Lys 
225                 230                 235                 240 


Leu Leu Gln Glu Cys Lys Lys Ile Ile Val Leu Thr Gly Ala Gly Val 
                245                 250                 255     


Ser Val Ser Cys Gly Ile Pro Asp Phe Arg Ser Arg Asp Gly Ile Tyr 
            260                 265                 270         


Ala Arg Leu Ala Val Asp Phe Pro Asp Leu Pro Asp Pro Gln Ala Met 
        275                 280                 285             


Phe Asp Ile Glu Tyr Phe Arg Lys Asp Pro Arg Pro Phe Phe Lys Phe 
    290                 295                 300                 


Ala Lys Glu Ile Tyr Pro Gly Gln Phe Gln Pro Ser Leu Cys His Lys 
305                 310                 315                 320 


Phe Ile Ala Leu Ser Asp Lys Glu Gly Lys Leu Leu Arg Asn Tyr Thr 
                325                 330                 335     


Gln Asn Ile Asp Thr Leu Glu Gln Val Ala Gly Ile Gln Arg Ile Leu 
            340                 345                 350         


Gln Cys His Gly Ser Phe Ala Thr Ala Ser Cys Leu Ile Cys Lys Tyr 
        355                 360                 365             


Lys Val Asp Cys Glu Ala Val Arg Gly Asp Ile Phe Asn Gln Val Val 
    370                 375                 380                 


Pro Arg Cys Pro Arg Cys Pro Ala Asp Glu Pro Leu Ala Ile Met Lys 
385                 390                 395                 400 


Pro Glu Ile Val Phe Phe Gly Glu Asn Leu Pro Glu Gln Phe His Arg 
                405                 410                 415     


Ala Met Lys Tyr Asp Lys Asp Glu Val Asp Leu Leu Ile Val Ile Gly 
            420                 425                 430         


Ser Ser Leu Lys Val Arg Pro Val Ala Leu Ile Pro Ser Ser Ile Pro 
        435                 440                 445             


His Glu Val Pro Gln Ile Leu Ile Asn Arg Glu Pro Leu Pro His Leu 
    450                 455                 460                 


His Phe Asp Val Glu Leu Leu Gly Asp Cys Asp Val Ile Ile Asn Glu 
465                 470                 475                 480 


Leu Cys His Arg Leu Gly Gly Glu Tyr Ala Lys Leu Cys Cys Asn Pro 
                485                 490                 495     


Val Lys Leu Ser Glu Ile Thr Glu Lys Pro Pro Arg Pro Gln Lys Glu 
            500                 505                 510         


Leu Val His Leu Ser Glu Leu Pro Pro Thr Pro Leu His Ile Ser Glu 
        515                 520                 525             


Asp Ser Ser Ser Pro Glu Arg Thr Val Pro Gln Asp Ser Ser Val Ile 
    530                 535                 540                 


Ala Thr Leu Val Asp Gln Ala Thr Asn Asn Asn Val Asn Asp Leu Glu 
545                 550                 555                 560 


Val Ser Glu Ser Ser Cys Val Glu Glu Lys Pro Gln Glu Val Gln Thr 
                565                 570                 575     


Ser Arg Asn Val Glu Asn Ile Asn Val Glu Asn Pro Asp Phe Lys Ala 
            580                 585                 590         


Val Gly Ser Ser Thr Ala Asp Lys Asn Glu Arg Thr Ser Val Ala Glu 
        595                 600                 605             


Thr Val Arg Lys Cys Trp Pro Asn Arg Leu Ala Lys Glu Gln Ile Ser 
    610                 615                 620                 


Lys Arg Leu Glu Gly Asn Gln Tyr Leu Phe Val Pro Pro Asn Arg Tyr 
625                 630                 635                 640 


Ile Phe His Gly Ala Glu Val Tyr Ser Asp Ser Glu Asp Asp Val Leu 
                645                 650                 655     


Ser Ser Ser Ser Cys Gly Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser 
            660                 665                 670         


Pro Ser Leu Glu Glu Pro Leu Glu Asp Glu Ser Glu Ile Glu Glu Phe 
        675                 680                 685             


Tyr Asn Gly Leu Glu Asp Asp Thr Glu Arg Pro Glu Cys Ala Gly Gly 
    690                 695                 700                 


Ser Gly Phe Gly Ala Asp Gly Gly Asp Gln Glu Val Val Asn Glu Ala 
705                 710                 715                 720 


Ile Ala Thr Arg Gln Glu Leu Thr Asp Val Asn Tyr Pro Ser Asp Lys 
                725                 730                 735     


Ser 
    


<210>  52
<211>  333
<212>  PRT
<213>  Mus musculus

<400>  52

Met Ser Gly Leu Thr Phe Arg Pro Thr Lys Gly Arg Trp Ile Thr His 
1               5                   10                  15      


Leu Ser Arg Pro Arg Ser Cys Gly Pro Ser Gly Leu Phe Val Pro Pro 
            20                  25                  30          


Ser Pro Pro Leu Asp Pro Glu Lys Ile Lys Glu Leu Gln Arg Phe Ile 
        35                  40                  45              


Ser Leu Ser Lys Lys Leu Leu Val Met Thr Gly Ala Gly Ile Ser Thr 
    50                  55                  60                  


Glu Ser Gly Ile Pro Asp Tyr Arg Ser Glu Lys Val Gly Leu Tyr Ala 
65                  70                  75                  80  


Arg Thr Asp Arg Arg Pro Ile Gln His Ile Asp Phe Val Arg Ser Ala 
                85                  90                  95      


Pro Val Arg Gln Arg Tyr Trp Ala Arg Asn Phe Val Gly Trp Pro Gln 
            100                 105                 110         


Phe Ser Ser His Gln Pro Asn Pro Ala His Trp Ala Leu Ser Asn Trp 
        115                 120                 125             


Glu Arg Leu Gly Lys Leu His Trp Leu Val Thr Gln Asn Val Asp Ala 
    130                 135                 140                 


Leu His Ser Lys Ala Gly Ser Gln Arg Leu Thr Glu Leu His Gly Cys 
145                 150                 155                 160 


Met His Arg Val Leu Cys Leu Asn Cys Gly Glu Gln Thr Ala Arg Arg 
                165                 170                 175     


Val Leu Gln Glu Arg Phe Gln Ala Leu Asn Pro Ser Trp Ser Ala Glu 
            180                 185                 190         


Ala Gln Gly Val Ala Pro Asp Gly Asp Val Phe Leu Thr Glu Glu Gln 
        195                 200                 205             


Val Arg Ser Phe Gln Val Pro Cys Cys Asp Arg Cys Gly Gly Pro Leu 
    210                 215                 220                 


Lys Pro Asp Val Val Phe Phe Gly Asp Thr Val Asn Pro Asp Lys Val 
225                 230                 235                 240 


Asp Phe Val His Arg Arg Val Lys Glu Ala Asp Ser Leu Leu Val Val 
                245                 250                 255     


Gly Ser Ser Leu Gln Val Tyr Ser Gly Tyr Arg Phe Ile Leu Thr Ala 
            260                 265                 270         


Arg Glu Gln Lys Leu Pro Ile Ala Ile Leu Asn Ile Gly Pro Thr Arg 
        275                 280                 285             


Ser Asp Asp Leu Ala Cys Leu Lys Leu Asp Ser Arg Cys Gly Glu Leu 
    290                 295                 300                 


Leu Pro Leu Ile Asp Pro Arg Arg Gln His Ser Asp Val Gln Arg Leu 
305                 310                 315                 320 


Glu Met Asn Phe Pro Leu Ser Ser Ala Ala Gln Asp Pro 
                325                 330             


<210>  53
<211>  298
<212>  PRT
<213>  Mus musculus

<400>  53

Met Thr Asp Ala Ala Val Ser Phe Ala Lys Asp Phe Leu Ala Gly Gly 
1               5                   10                  15      


Val Ala Ala Ala Ile Ser Lys Thr Ala Val Ala Pro Ile Glu Arg Val 
            20                  25                  30          


Lys Leu Leu Leu Gln Val Gln His Ala Ser Lys Gln Ile Thr Ala Asp 
        35                  40                  45              


Lys Gln Tyr Lys Gly Ile Ile Asp Cys Val Val Arg Ile Pro Lys Glu 
    50                  55                  60                  


Gln Gly Val Leu Ser Phe Trp Arg Gly Asn Leu Ala Asn Val Ile Arg 
65                  70                  75                  80  


Tyr Phe Pro Thr Gln Ala Leu Asn Phe Ala Phe Lys Asp Lys Tyr Lys 
                85                  90                  95      


Gln Ile Phe Leu Gly Gly Val Asp Lys Arg Thr Gln Phe Trp Arg Tyr 
            100                 105                 110         


Phe Ala Gly Asn Leu Ala Ser Gly Gly Ala Ala Gly Ala Thr Ser Leu 
        115                 120                 125             


Cys Phe Val Tyr Pro Leu Asp Phe Ala Arg Thr Arg Leu Ala Ala Asp 
    130                 135                 140                 


Val Gly Lys Ala Gly Ala Glu Arg Glu Phe Lys Gly Leu Gly Asp Cys 
145                 150                 155                 160 


Leu Val Lys Ile Tyr Lys Ser Asp Gly Ile Lys Gly Leu Tyr Gln Gly 
                165                 170                 175     


Phe Asn Val Ser Val Gln Gly Ile Ile Ile Tyr Arg Ala Ala Tyr Phe 
            180                 185                 190         


Gly Ile Tyr Asp Thr Ala Lys Gly Met Leu Pro Asp Pro Lys Asn Thr 
        195                 200                 205             


His Ile Phe Ile Ser Trp Met Ile Ala Gln Ser Val Thr Ala Val Ala 
    210                 215                 220                 


Gly Leu Thr Ser Tyr Pro Phe Asp Thr Val Arg Arg Arg Met Met Met 
225                 230                 235                 240 


Gln Ser Gly Arg Lys Gly Thr Asp Ile Met Tyr Thr Gly Thr Leu Asp 
                245                 250                 255     


Cys Trp Arg Lys Ile Ala Arg Asp Glu Gly Ser Lys Ala Phe Phe Lys 
            260                 265                 270         


Gly Ala Trp Ser Asn Val Leu Arg Gly Met Gly Gly Ala Phe Val Leu 
        275                 280                 285             


Val Leu Tyr Asp Glu Ile Lys Lys Tyr Thr 
    290                 295             


<210>  54
<211>  337
<212>  PRT
<213>  Mus musculus

<400>  54

Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Thr Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Thr Met Lys Thr 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Thr Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Leu Phe Leu Ile Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Lys Lys Tyr Arg Asp Asn Arg Thr Arg Gln His Ile Pro Tyr Arg 
                165                 170                 175     


Glu Asp Lys Asn Leu Thr Gly Thr Ala Arg Tyr Ala Ser Ile Asn Ala 
            180                 185                 190         


His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly 
        195                 200                 205             


Tyr Val Leu Met Tyr Phe Asn Arg Thr Ser Leu Pro Trp Gln Gly Leu 
    210                 215                 220                 


Lys Ala Ala Thr Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys 
225                 230                 235                 240 


Met Ser Thr Pro Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe 
                245                 250                 255     


Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro 
            260                 265                 270         


Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Thr Leu 
        275                 280                 285             


Asn His Gln Tyr Asp Tyr Thr Phe Asp Trp Thr Met Leu Lys Gln Lys 
    290                 295                 300                 


Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln 
305                 310                 315                 320 


Thr Pro Thr Gly Lys Gln Thr Asp Lys Thr Lys Ser Asn Met Lys Gly 
                325                 330                 335     


Phe 
    


<210>  55
<211>  353
<212>  PRT
<213>  Mus musculus

<400>  55

Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Thr Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Thr Met Lys Thr 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Thr Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Cys Leu Glu Ser Pro Val Gly Lys 
145                 150                 155                 160 


Arg Lys Arg Ser Met Thr Val Ser Pro Ser Gln Asp Pro Ser Phe Ser 
                165                 170                 175     


Gly Leu Asn Gln Leu Phe Leu Ile Asp Phe Gly Leu Ala Lys Lys Tyr 
            180                 185                 190         


Arg Asp Asn Arg Thr Arg Gln His Ile Pro Tyr Arg Glu Asp Lys Asn 
        195                 200                 205             


Leu Thr Gly Thr Ala Arg Tyr Ala Ser Ile Asn Ala His Leu Gly Ile 
    210                 215                 220                 


Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly Tyr Val Leu Met 
225                 230                 235                 240 


Tyr Phe Asn Arg Thr Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Thr 
                245                 250                 255     


Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys Met Ser Thr Pro 
            260                 265                 270         


Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe Ala Met Tyr Leu 
        275                 280                 285             


Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro Asp Tyr Met Tyr 
    290                 295                 300                 


Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Thr Leu Asn His Gln Tyr 
305                 310                 315                 320 


Asp Tyr Thr Phe Asp Trp Thr Met Leu Lys Gln Lys Ala Ala Gln Gln 
                325                 330                 335     


Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln Thr Pro Thr Gly 
            340                 345                 350         


Phe 
    


<210>  56
<211>  337
<212>  PRT
<213>  Mus musculus

<400>  56

Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Thr Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Thr Met Lys Thr 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Thr Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Leu Phe Leu Ile Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Lys Lys Tyr Arg Asp Asn Arg Thr Arg Gln His Ile Pro Tyr Arg 
                165                 170                 175     


Glu Asp Lys Asn Leu Thr Gly Thr Ala Arg Tyr Ala Ser Ile Asn Ala 
            180                 185                 190         


His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly 
        195                 200                 205             


Tyr Val Leu Met Tyr Phe Asn Arg Thr Ser Leu Pro Trp Gln Gly Leu 
    210                 215                 220                 


Lys Ala Ala Thr Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys 
225                 230                 235                 240 


Met Ser Thr Pro Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe 
                245                 250                 255     


Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro 
            260                 265                 270         


Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Thr Leu 
        275                 280                 285             


Asn His Gln Tyr Asp Tyr Thr Phe Asp Trp Thr Met Leu Lys Gln Lys 
    290                 295                 300                 


Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln 
305                 310                 315                 320 


Thr Pro Thr Gly Lys Gln Thr Asp Lys Thr Lys Ser Asn Met Lys Gly 
                325                 330                 335     


Phe 
    


<210>  57
<211>  334
<212>  PRT
<213>  Mus musculus

<400>  57

Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Thr Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Thr Met Lys Thr 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Thr Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Leu Phe Leu Ile Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Lys Lys Tyr Arg Asp Asn Arg Thr Arg Gln His Ile Pro Tyr Arg 
                165                 170                 175     


Glu Asp Lys Asn Leu Thr Gly Thr Ala Arg Tyr Ala Ser Ile Asn Ala 
            180                 185                 190         


His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly 
        195                 200                 205             


Tyr Val Leu Met Tyr Phe Asn Arg Thr Ser Leu Pro Trp Gln Gly Leu 
    210                 215                 220                 


Lys Ala Ala Thr Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys 
225                 230                 235                 240 


Met Ser Thr Pro Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe 
                245                 250                 255     


Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro 
            260                 265                 270         


Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Thr Leu 
        275                 280                 285             


Asn His Gln Tyr Asp Tyr Thr Phe Asp Trp Thr Met Leu Lys Gln Lys 
    290                 295                 300                 


Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln 
305                 310                 315                 320 


Thr Pro Thr Gly Ile Lys Asp Glu Lys Leu Asp Pro Leu Ser 
                325                 330                 


<210>  58
<211>  336
<212>  PRT
<213>  Mus musculus

<400>  58

Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Thr Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Thr Met Lys Thr 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Thr Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Leu Phe Leu Ile Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Lys Lys Tyr Arg Asp Asn Arg Thr Arg Gln His Ile Pro Tyr Arg 
                165                 170                 175     


Glu Asp Lys Asn Leu Thr Gly Thr Ala Arg Tyr Ala Ser Ile Asn Ala 
            180                 185                 190         


His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly 
        195                 200                 205             


Tyr Val Leu Met Tyr Phe Asn Arg Thr Ser Leu Pro Trp Gln Gly Leu 
    210                 215                 220                 


Lys Ala Ala Thr Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys 
225                 230                 235                 240 


Met Ser Thr Pro Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe 
                245                 250                 255     


Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro 
            260                 265                 270         


Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Thr Leu 
        275                 280                 285             


Asn His Gln Tyr Asp Tyr Thr Phe Asp Trp Thr Met Leu Lys Gln Lys 
    290                 295                 300                 


Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln 
305                 310                 315                 320 


Thr Pro Thr Gly Lys Gln Thr Asp Lys Thr Lys Ser Asn Met Lys Gly 
                325                 330                 335     


<210>  59
<211>  365
<212>  PRT
<213>  Mus musculus

<400>  59

Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Thr Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Thr Met Lys Thr 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Thr Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Cys Leu Glu Ser Pro Val Gly Lys 
145                 150                 155                 160 


Arg Lys Arg Ser Met Thr Val Ser Pro Ser Gln Asp Pro Ser Phe Ser 
                165                 170                 175     


Gly Leu Asn Gln Leu Phe Leu Ile Asp Phe Gly Leu Ala Lys Lys Tyr 
            180                 185                 190         


Arg Asp Asn Arg Thr Arg Gln His Ile Pro Tyr Arg Glu Asp Lys Asn 
        195                 200                 205             


Leu Thr Gly Thr Ala Arg Tyr Ala Ser Ile Asn Ala His Leu Gly Ile 
    210                 215                 220                 


Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly Tyr Val Leu Met 
225                 230                 235                 240 


Tyr Phe Asn Arg Thr Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Thr 
                245                 250                 255     


Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys Met Ser Thr Pro 
            260                 265                 270         


Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe Ala Met Tyr Leu 
        275                 280                 285             


Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro Asp Tyr Met Tyr 
    290                 295                 300                 


Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Thr Leu Asn His Gln Tyr 
305                 310                 315                 320 


Asp Tyr Thr Phe Asp Trp Thr Met Leu Lys Gln Lys Ala Ala Gln Gln 
                325                 330                 335     


Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln Thr Pro Thr Gly 
            340                 345                 350         


Lys Gln Thr Asp Lys Thr Lys Ser Asn Met Lys Gly Phe 
        355                 360                 365 


<210>  60
<211>  374
<212>  PRT
<213>  Mus musculus

<400>  60

Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Thr Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Thr Met Lys Thr 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Thr Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Leu Phe Leu Ile Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Lys Lys Tyr Arg Asp Asn Arg Thr Arg Gln His Ile Pro Tyr Arg 
                165                 170                 175     


Glu Asp Lys Asn Leu Thr Gly Thr Ala Arg Tyr Ala Ser Ile Asn Ala 
            180                 185                 190         


His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly 
        195                 200                 205             


Tyr Val Leu Met Tyr Phe Asn Arg Thr Ser Leu Pro Trp Gln Gly Leu 
    210                 215                 220                 


Lys Ala Ala Thr Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys 
225                 230                 235                 240 


Met Ser Thr Pro Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe 
                245                 250                 255     


Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro 
            260                 265                 270         


Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Thr Leu 
        275                 280                 285             


Asn His Gln Tyr Asp Tyr Thr Phe Asp Trp Thr Met Leu Lys Gln Lys 
    290                 295                 300                 


Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln 
305                 310                 315                 320 


Thr Pro Thr Gly Lys Gln Thr Asp Lys Thr Lys Ser Tyr Ser Glu Asp 
                325                 330                 335     


Ala Leu Trp Asn Gln Arg Cys Arg Pro Asp Tyr Lys Ile Leu Lys Ser 
            340                 345                 350         


Asn Lys Arg Leu Lys His Thr Gly Arg Glu Cys Leu Leu Val Val Glu 
        355                 360                 365             


Asp Trp Met Leu Ala Cys 
    370                 


<210>  61
<211>  159
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  61

Xaa Ser Ile Asn Ala His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp 
1               5                   10                  15      


Met Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Arg Thr Ser Leu 
            20                  25                  30          


Pro Trp Gln Gly Leu Lys Ala Ala Thr Lys Lys Gln Lys Tyr Glu Lys 
        35                  40                  45              


Ile Ser Glu Lys Lys Met Ser Thr Pro Val Glu Val Leu Cys Lys Gly 
    50                  55                  60                  


Phe Pro Ala Glu Phe Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg 
65                  70                  75                  80  


Phe Glu Glu Ala Pro Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile 
                85                  90                  95      


Leu Phe Arg Thr Leu Asn His Gln Tyr Asp Tyr Thr Phe Asp Trp Thr 
            100                 105                 110         


Met Leu Lys Gln Lys Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln 
        115                 120                 125             


Gly Gln Gln Ala Gln Thr Pro Thr Gly Lys Gln Thr Asp Lys Thr Lys 
    130                 135                 140                 


Ser Asn Met Lys Gly Ile Lys Asp Glu Lys Leu Asp Pro Leu Ser 
145                 150                 155                 


<210>  62
<211>  1021
<212>  PRT
<213>  Mus musculus

<400>  62

Met Asn Leu Phe Asn Leu Asp Arg Phe Arg Phe Glu Lys Arg Ser Lys 
1               5                   10                  15      


Ile Glu Glu Ala Pro Glu Ala Ala Pro Gln Pro Ser Gln Ala Arg Pro 
            20                  25                  30          


Ser Ser Pro Ile Ser Leu Ser Ala Glu Glu Glu Asn Ala Glu Gly Glu 
        35                  40                  45              


Gly Ser Arg Ala Asn Thr Pro Asp Ser Asp Val Thr Glu Lys Thr Glu 
    50                  55                  60                  


Asp Ser Ser Val Pro Glu Pro Pro Asp Asn Glu Arg Lys Ala Ser Leu 
65                  70                  75                  80  


Ser Cys Phe Gln Asn Gln Arg Ala Ile Gln Glu Tyr Ile Asp Leu Ser 
                85                  90                  95      


Ser Asp Thr Glu Asp Val Ser Pro Asn Cys Ser Ser Thr Val Gln Glu 
            100                 105                 110         


Lys Lys Phe Ser Lys Asp Thr Val Ile Ile Val Ser Glu Pro Ser Glu 
        115                 120                 125             


Asp Glu Glu Ser His Asp Leu Pro Ser Val Thr Arg Arg Asn Asp Ser 
    130                 135                 140                 


Ser Glu Leu Glu Asp Leu Ser Glu Leu Glu Asp Leu Lys Asp Ala Lys 
145                 150                 155                 160 


Leu Gln Thr Leu Lys Glu Leu Phe Pro Gln Arg Ser Asp Ser Asp Leu 
                165                 170                 175     


Leu Lys Leu Ile Glu Ser Thr Ser Thr Met Asp Gly Ala Ile Ala Ala 
            180                 185                 190         


Ala Leu Leu Met Phe Gly Asp Ala Gly Gly Gly Pro Arg Lys Arg Lys 
        195                 200                 205             


Leu Ser Ser Ser Ser Glu Glu Asp Asp Val Asn Asp Asp Gln Ser Val 
    210                 215                 220                 


Lys Gln Pro Arg Gly Asp Arg Gly Glu Glu Ser Asn Glu Ser Ala Glu 
225                 230                 235                 240 


Ala Ser Ser Asn Trp Glu Lys Gln Glu Ser Ile Val Leu Lys Leu Gln 
                245                 250                 255     


Lys Glu Phe Pro Asn Phe Asp Lys Gln Glu Leu Arg Glu Val Leu Lys 
            260                 265                 270         


Glu His Glu Trp Met Tyr Thr Glu Ala Leu Glu Ser Leu Lys Val Phe 
        275                 280                 285             


Ala Glu Asp Gln Asp Val Gln Cys Ala Ser Gln Ser Glu Val Thr Asn 
    290                 295                 300                 


Gly Lys Glu Val Ala Arg Asn Gln Asn Tyr Ser Lys Asn Ala Thr Lys 
305                 310                 315                 320 


Ile Lys Met Lys Gln Lys Ile Ser Val Lys Pro Gln Asn Gly Phe Asn 
                325                 330                 335     


Lys Lys Arg Lys Lys Asn Val Phe Asn Pro Lys Lys Ala Val Glu Asp 
            340                 345                 350         


Ser Glu Tyr Asp Ser Gly Ser Asp Ala Gly Ser Ser Leu Asp Glu Asp 
        355                 360                 365             


Tyr Ser Ser Cys Glu Glu Val Met Glu Asp Gly Tyr Lys Gly Lys Ile 
    370                 375                 380                 


Leu His Phe Leu Gln Val Ser Ser Ile Ala Glu Leu Thr Leu Ile Pro 
385                 390                 395                 400 


Lys Cys Ser Gln Lys Lys Ala Gln Lys Ile Thr Glu Leu Arg Pro Phe 
                405                 410                 415     


Asn Asn Trp Glu Ala Leu Phe Thr Lys Met Ser Lys Ile Asn Gly Leu 
            420                 425                 430         


Ser Glu Asp Leu Ile Trp Asn Cys Lys Thr Val Ile Gln Glu Arg Asp 
        435                 440                 445             


Val Val Ile Arg Leu Met Asn Lys Cys Glu Asp Ile Ser Asn Lys Leu 
    450                 455                 460                 


Thr Lys Gln Val Thr Met Leu Thr Gly Asn Gly Gly Gly Trp Asn Arg 
465                 470                 475                 480 


Glu Gln Pro Ser Leu Leu Asn Gln Ser Leu Ser Leu Lys Pro Tyr Gln 
                485                 490                 495     


Lys Val Gly Leu Asn Trp Leu Ala Leu Val His Lys His Gly Leu Asn 
            500                 505                 510         


Gly Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Ala Ile 
        515                 520                 525             


Ala Phe Leu Ala Tyr Leu Phe Gln Glu Gly Asn Lys Gly Pro His Leu 
    530                 535                 540                 


Ile Val Val Pro Ala Ser Thr Ile Asp Asn Trp Leu Arg Glu Val Asn 
545                 550                 555                 560 


Leu Trp Cys Pro Ser Leu Asn Val Leu Cys Tyr Tyr Gly Ser Gln Glu 
                565                 570                 575     


Glu Arg Lys Gln Ile Arg Phe Asn Ile His Asn Lys Tyr Glu Asp Tyr 
            580                 585                 590         


Asn Val Ile Val Thr Thr Tyr Asn Cys Ala Ile Ser Ser Ser Asp Asp 
        595                 600                 605             


Arg Ser Leu Phe Arg Arg Leu Lys Leu Asn Tyr Ala Ile Phe Asp Glu 
    610                 615                 620                 


Gly His Met Leu Lys Asn Met Gly Ser Ile Arg Tyr Gln His Leu Met 
625                 630                 635                 640 


Thr Ile Asn Ala Arg Asn Arg Leu Leu Leu Thr Gly Thr Pro Val Gln 
                645                 650                 655     


Asn Asn Leu Leu Glu Leu Met Ser Leu Leu Asn Phe Val Met Pro His 
            660                 665                 670         


Met Phe Ser Ser Ser Thr Ser Glu Ile Arg Arg Met Phe Ser Ser Lys 
        675                 680                 685             


Thr Lys Pro Ala Asp Glu Gln Ser Ile Tyr Glu Lys Glu Arg Ile Ala 
    690                 695                 700                 


His Ala Lys Gln Ile Ile Lys Pro Phe Ile Leu Arg Arg Val Lys Glu 
705                 710                 715                 720 


Glu Val Leu Lys Leu Leu Pro Pro Lys Lys Asp Arg Ile Glu Leu Cys 
                725                 730                 735     


Ala Met Ser Glu Lys Gln Glu Gln Leu Tyr Ser Gly Leu Phe Asn Arg 
            740                 745                 750         


Leu Lys Lys Ser Ile Asn Asn Leu Glu Lys Asn Thr Glu Met Cys Asn 
        755                 760                 765             


Val Met Met Gln Leu Arg Lys Met Ala Asn His Pro Leu Leu His Arg 
    770                 775                 780                 


Gln Tyr Tyr Thr Pro Glu Lys Leu Lys Glu Met Ser Gln Leu Met Leu 
785                 790                 795                 800 


Lys Glu Pro Thr His Cys Glu Ala Asn Pro Asp Leu Ile Phe Glu Asp 
                805                 810                 815     


Met Glu Val Met Thr Asp Phe Glu Leu His Val Leu Cys Lys Gln Tyr 
            820                 825                 830         


Gln His Ile Asn Ser Tyr Gln Leu Asp Met Asp Leu Ile Leu Asp Ser 
        835                 840                 845             


Gly Lys Phe Arg Ala Leu Gly Cys Ile Leu Ser Glu Leu Lys Gln Lys 
    850                 855                 860                 


Gly Asp Arg Val Val Leu Phe Ser Gln Phe Thr Met Met Leu Asp Ile 
865                 870                 875                 880 


Leu Glu Val Leu Leu Lys His His Gln His Arg Tyr Leu Arg Leu Asp 
                885                 890                 895     


Gly Lys Thr Gln Ile Ser Glu Arg Ile His Leu Ile Asp Glu Phe Asn 
            900                 905                 910         


Thr Asp Met Asp Ile Phe Val Phe Leu Leu Ser Thr Lys Ala Gly Gly 
        915                 920                 925             


Leu Gly Ile Asn Leu Thr Ser Ala Asn Val Val Ile Leu His Asp Ile 
    930                 935                 940                 


Asp Cys Asn Pro Tyr Asn Asp Lys Gln Ala Glu Asp Arg Cys His Arg 
945                 950                 955                 960 


Val Gly Gln Thr Lys Glu Val Leu Val Ile Lys Leu Ile Ser Gln Gly 
                965                 970                 975     


Thr Ile Glu Glu Ser Met Leu Lys Ile Asn Gln Gln Lys Leu Lys Leu 
            980                 985                 990         


Glu Gln Asp Met Thr Thr Val Asp  Glu Ala Asp Glu Gly  Ser Met Pro 
        995                 1000                 1005             


Ala Asp  Ile Ala Thr Leu Leu  Lys Thr Ser Met Gly  Leu 
    1010                 1015                 1020     


<210>  63
<211>  1017
<212>  PRT
<213>  Mus musculus

<400>  63

Met Ser Gln Gly Pro Pro Pro Gly Glu Ser Ser Glu Pro Glu Ala Lys 
1               5                   10                  15      


Val Leu His Thr Lys Arg Leu Tyr Arg Ala Val Val Glu Ala Val His 
            20                  25                  30          


Arg Leu Asp Leu Ile Leu Cys Asn Lys Ala Ala Tyr Gln Glu Val Phe 
        35                  40                  45              


Lys Pro Glu Asn Val Ser Leu Arg Asn Lys Leu Arg Glu Leu Cys Val 
    50                  55                  60                  


Lys Leu Met Phe Leu His Pro Val Asp Tyr Gly Arg Lys Ala Glu Glu 
65                  70                  75                  80  


Leu Leu Trp Arg Lys Val Tyr Tyr Glu Val Ile Gln Leu Ile Lys Thr 
                85                  90                  95      


Asn Lys Lys His Ile His Ser Arg Ser Thr Leu Glu Cys Ala Tyr Arg 
            100                 105                 110         


Thr His Leu Val Ala Gly Ile Gly Phe Tyr Gln His Leu Leu Leu Tyr 
        115                 120                 125             


Ile Gln Ser His Tyr Gln Leu Glu Leu Gln Cys Cys Ile Asp Trp Thr 
    130                 135                 140                 


His Val Thr Asp Pro Leu Met Gly Phe Lys Lys Pro Val Ser Ala Ser 
145                 150                 155                 160 


Gly Lys Glu Met Asp Trp Ala Gln Met Ala Cys His Arg Cys Leu Val 
                165                 170                 175     


Tyr Leu Gly Asp Leu Ser Arg Tyr Gln Asn Glu Leu Ala Gly Val Asp 
            180                 185                 190         


Thr Glu Leu Leu Ala Glu Arg Phe Tyr Tyr Gln Ala Leu Ser Val Ala 
        195                 200                 205             


Pro Gln Ile Gly Met Pro Phe Asn Gln Leu Gly Thr Leu Ala Gly Ser 
    210                 215                 220                 


Lys Tyr Tyr Asn Val Glu Ala Met Tyr Cys Tyr Leu Arg Cys Ile Gln 
225                 230                 235                 240 


Ser Glu Val Ser Phe Glu Gly Ala Tyr Gly Asn Leu Lys Arg Leu Tyr 
                245                 250                 255     


Asp Lys Ala Ala Lys Met Tyr His Gln Leu Lys Lys Ser Glu Thr Arg 
            260                 265                 270         


Lys Leu Ser Pro Ser Lys Lys Arg Cys Lys Asp Ile Lys Arg Leu Leu 
        275                 280                 285             


Val Asn Phe Met Tyr Leu Gln Ser Leu Leu Gln Pro Lys Ser Ser Ser 
    290                 295                 300                 


Val Asp Ser Glu Leu Thr Ser Leu Cys Gln Ser Val Leu Glu Asp Phe 
305                 310                 315                 320 


Asn Leu Cys Leu Phe Tyr Leu Pro Ser Ser Pro Asn Leu Gly Leu Thr 
                325                 330                 335     


Asn Glu Asp Glu Glu Glu Cys Glu Ser Gly Tyr Ala Phe Leu Pro Asp 
            340                 345                 350         


Leu Leu Ile Phe Gln Met Ala Ile Ile Cys Leu Met Gly Val His Ser 
        355                 360                 365             


Leu Lys Arg Ala Gly Ser Lys His Tyr Ser Ala Ala Ile Ala Phe Thr 
    370                 375                 380                 


Leu Ala Leu Phe Ser His Leu Ile Asn His Val Asn Ile Arg Leu Gln 
385                 390                 395                 400 


Ala Glu Leu Glu Glu Gly Glu Asn Pro Val Ser Ala Phe Gln Ser Asp 
                405                 410                 415     


Gly Thr Asp Glu Pro Glu Ser Lys Glu Ala Leu Glu Lys Glu Glu Pro 
            420                 425                 430         


Glu Pro Glu Pro Pro Thr Val Val Pro Gln Ala Asp Glu Gly Arg Lys 
        435                 440                 445             


Ser Arg Lys His Ser Arg Leu Ser Cys Leu Arg Arg Arg Arg Arg His 
    450                 455                 460                 


His Pro Pro Lys Ala Gly Asp Asp Ser Asp Leu Ser Glu Gly Phe Glu 
465                 470                 475                 480 


Ser Asp Ser Ser His Asp Ser Ala Gln Ala Ser Asp Gly Ser Asp Ser 
                485                 490                 495     


Gly Ser Asp Lys Ser Leu Glu Gly Arg Gly Thr Ala Phe Asp Ala Glu 
            500                 505                 510         


Thr Asp Ser Glu Met Asn Ser Gln Glu Ser Arg Ser Asp Leu Glu Asp 
        515                 520                 525             


Met Glu Asp Glu Glu Gly Thr Arg Ser Pro Ala Gln Glu Pro Pro Gln 
    530                 535                 540                 


Ala Arg Ser Glu Val Pro Asp Ser Leu Asn Gly Pro Leu Gly Pro Ser 
545                 550                 555                 560 


Glu Ala Ser Ile Ala Ser Asn Leu Gln Ala Met Ser Thr Gln Met Phe 
                565                 570                 575     


Gln Thr Lys Arg Cys Phe Arg Leu Ala Pro Thr Phe Ser Asn Leu Leu 
            580                 585                 590         


Leu Gln Pro Thr Thr Glu Pro Asn Ser Val Ala Ser His Arg Pro Cys 
        595                 600                 605             


Val Asn Gly Asp Met Asp Lys Pro Leu Glu Pro Ala Ser Glu Asp Gly 
    610                 615                 620                 


Ser Glu Ser Glu Gly Ser Glu Ser Ser Asn Arg Ser Cys Arg Asn Glu 
625                 630                 635                 640 


Arg Ser Leu Gln Glu Lys Leu Gln Ala Leu Met Ala Glu Gly Leu Leu 
                645                 650                 655     


Pro Ala Val Lys Val Phe Leu Asp Trp Leu Arg Thr Asn Pro Asp Leu 
            660                 665                 670         


Ile Ile Val Cys Ala Gln Ser Ser Gln Ser Leu Trp Asn Arg Leu Ser 
        675                 680                 685             


Val Leu Leu Asn Leu Leu Pro Ala Ser Ala Glu Leu Gln Asp Ser Gly 
    690                 695                 700                 


Leu Ala Leu Cys Ser Glu Val Gln Gly Leu Leu Glu Gly Cys Glu Leu 
705                 710                 715                 720 


Pro Asp Leu Pro Ala Ser Leu Leu Leu Pro Glu Asp Met Ala Leu Arg 
                725                 730                 735     


Asn Leu Pro Pro Leu Arg Ala Ala His Arg Arg Phe Asn Phe Asp Ala 
            740                 745                 750         


Asp Arg Pro Leu Leu Ser Ala Leu Glu Glu Ser Val Val Arg Ile Cys 
        755                 760                 765             


Cys Ile Arg Ser Phe Gly His Phe Val Ala Arg Leu Gln Gly Ser Ile 
    770                 775                 780                 


Leu Gln Phe Asn Pro Glu Val Gly Ile Phe Val Ser Ile Ala Gln Ser 
785                 790                 795                 800 


Glu Gln Glu Ser Leu Leu Gln Gln Ala Gln Ala Gln Phe Arg Met Ala 
                805                 810                 815     


Glu Glu Glu Ala Arg Arg Asn Arg Leu Met Arg Asp Met Ala Gln Leu 
            820                 825                 830         


Arg Leu Gln Leu Glu Val Ser Gln Leu Glu Gly Ser Leu Gln Gln Pro 
        835                 840                 845             


Lys Ala Gln Ser Ala Met Ser Pro Tyr Leu Ile Pro Asp Thr Gln Ala 
    850                 855                 860                 


Leu Cys Tyr His Leu Pro Leu Ile Arg Gln Leu Ala Thr Ser Gly Arg 
865                 870                 875                 880 


Phe Ile Ile Ile Ile Pro Arg Thr Val Ile Asp Gly Leu Asp Leu Leu 
                885                 890                 895     


Lys Lys Glu Gln Pro Gly Ala Arg Asp Gly Ile Arg Tyr Leu Glu Ala 
            900                 905                 910         


Glu Phe Lys Lys Gly Asn Arg Tyr Ile Arg Cys Gln Lys Glu Val Gly 
        915                 920                 925             


Lys Ser Phe Glu Arg His Lys Leu Lys Arg Gln Asp Ala Asp Ala Trp 
    930                 935                 940                 


Thr Leu Tyr Lys Ile Leu Asp Ser Cys Arg Gln Leu Thr Leu Ala Gln 
945                 950                 955                 960 


Gly Ala Gly Glu Glu Asp Pro Ser Gly Met Val Thr Ile Ile Thr Gly 
                965                 970                 975     


Leu His Leu Asp Ser Pro Ser Ala Leu Ser Gly Pro Met Gln Ala Ala 
            980                 985                 990         


Leu Gln Ala Ala Ala His Ala Ser  Val Asp Val Lys Asn  Val Leu Asp 
        995                 1000                 1005             


Phe Tyr  Arg Gln Trp Lys Glu  Ile Gly 
    1010                 1015         


<210>  64
<211>  1138
<212>  PRT
<213>  Mus musculus

<400>  64

Met Ser Leu Gln Ser Ala Gln Tyr Leu Arg Gln Ala Glu Val Leu Lys 
1               5                   10                  15      


Ala Glu Met Thr Asp Ser Lys Leu Gly Pro Ala Glu Val Trp Thr Ser 
            20                  25                  30          


Arg Gln Ala Leu Gln Asp Leu Tyr Gln Lys Met Leu Val Thr Asp Leu 
        35                  40                  45              


Glu Tyr Ala Leu Asp Lys Lys Val Glu Gln Asp Leu Trp Asn His Ala 
    50                  55                  60                  


Phe Lys Asn Gln Ile Thr Thr Leu Gln Gly Gln Ala Lys Asn Arg Ala 
65                  70                  75                  80  


Asn Pro Asn Arg Ser Glu Val Gln Ala Asn Leu Ser Leu Phe Leu Glu 
                85                  90                  95      


Ala Ala Ser Gly Phe Tyr Thr Gln Leu Leu Gln Glu Leu Cys Thr Val 
            100                 105                 110         


Phe Asn Val Asp Leu Pro Cys Arg Val Lys Ser Ser Gln Leu Gly Ile 
        115                 120                 125             


Ile Ser Asn Lys Gln Thr His Ser Ser Thr Ile Val Lys Pro Gln Ser 
    130                 135                 140                 


Ser Ser Cys Ser Tyr Ile Cys Gln His Cys Leu Val His Leu Gly Asp 
145                 150                 155                 160 


Ile Ala Arg Tyr Arg Asn Gln Thr Ser Gln Ala Glu Ser Tyr Tyr Arg 
                165                 170                 175     


His Ala Ala Gln Leu Val Pro Ser Asn Gly Gln Pro Tyr Asn Gln Leu 
            180                 185                 190         


Ala Ile Leu Ala Ser Ser Lys Gly Asp His Leu Thr Thr Ile Phe Tyr 
        195                 200                 205             


Tyr Cys Arg Ser Ile Ala Val Lys Phe Pro Phe Pro Ala Ala Ser Thr 
    210                 215                 220                 


Asn Leu Gln Lys Ala Leu Ser Lys Ala Leu Glu Ser Arg Asp Glu Leu 
225                 230                 235                 240 


Lys Thr Lys Trp Gly Val Ser Asp Phe Ile Lys Ala Phe Ile Lys Phe 
                245                 250                 255     


His Gly His Val Tyr Leu Ser Lys Ser Leu Glu Lys Leu Ser Pro Leu 
            260                 265                 270         


Arg Glu Lys Leu Glu Glu Gln Phe Lys Arg Leu Leu Phe Gln Lys Ala 
        275                 280                 285             


Phe Asn Ser Gln Gln Leu Val His Val Thr Val Ile Asn Leu Phe Gln 
    290                 295                 300                 


Leu His His Leu Arg Asp Phe Ser Asn Glu Thr Glu Gln His Ser Tyr 
305                 310                 315                 320 


Ser Gln Asp Glu Gln Leu Cys Trp Thr Gln Leu Leu Ala Leu Phe Met 
                325                 330                 335     


Ser Phe Leu Gly Ile Leu Cys Lys Cys Pro Leu Gln Asn Asp Ser Gln 
            340                 345                 350         


Glu Ser Asn Asn Ala Tyr Pro Leu Pro Ala Val Lys Val Ser Met Asp 
        355                 360                 365             


Trp Leu Arg Leu Arg Pro Arg Val Phe Gln Glu Ala Val Val Asp Glu 
    370                 375                 380                 


Arg Gln Tyr Ile Trp Pro Trp Leu Ile Ser Leu Leu Asn Ser Phe His 
385                 390                 395                 400 


Pro Arg Glu Asp Asp Leu Ser Asn Thr Asn Ala Thr Pro Leu Pro Glu 
                405                 410                 415     


Glu Phe Glu Leu Gln Gly Phe Leu Ala Leu Arg Pro Ser Phe Arg Asn 
            420                 425                 430         


Leu Asp Phe Ser Lys Gly His Gln Gly Ile Thr Gly Asp Lys Glu Gly 
        435                 440                 445             


Gln Gln Arg Arg Ile Arg Gln Gln Arg Leu Ile Ser Ile Gly Lys Trp 
    450                 455                 460                 


Ile Ala Asp Asn Gln Pro Arg Leu Ile Gln Cys Glu Asn Glu Val Gly 
465                 470                 475                 480 


Lys Leu Leu Phe Ile Thr Glu Ile Pro Glu Leu Ile Leu Glu Asp Pro 
                485                 490                 495     


Ser Glu Ala Lys Glu Asn Leu Ile Leu Gln Glu Thr Ser Val Val Glu 
            500                 505                 510         


Ser Leu Ala Thr Asp Gly Ser Pro Gly Leu Lys Ser Val Leu Ser Thr 
        515                 520                 525             


Gly Arg Asn Pro Ser Asn Ser Cys Asp Ser Gly Glu Lys Pro Val Val 
    530                 535                 540                 


Thr Phe Lys Glu Asn Ile Lys Pro Arg Glu Val Asn Gln Gly Arg Ser 
545                 550                 555                 560 


Phe Pro Pro Lys Glu Val Lys Ser Gln Thr Glu Leu Arg Lys Thr Pro 
                565                 570                 575     


Val Ser Glu Ala Arg Lys Thr Pro Val Thr Gln Thr Pro Ser Gln Thr 
            580                 585                 590         


Ser Asn Ser Gln Phe Ile Pro Ile His His Pro Gly Ala Phe Pro Pro 
        595                 600                 605             


Leu Pro Ser Arg Pro Gly Phe Pro Pro Pro Thr Tyr Val Ile Pro Pro 
    610                 615                 620                 


Pro Val Ala Phe Ser Met Gly Ser Gly Tyr Thr Phe Pro Ala Gly Val 
625                 630                 635                 640 


Ser Val Pro Gly Thr Phe Leu Gln Ser Thr Ala His Ser Pro Ala Gly 
                645                 650                 655     


Asn Gln Val Gln Ala Gly Lys Gln Ser His Ile Pro Tyr Ser Gln Gln 
            660                 665                 670         


Arg Pro Ser Gly Pro Gly Pro Met Asn Gln Gly Pro Gln Gln Ser Gln 
        675                 680                 685             


Pro Pro Ser Gln Pro Pro Leu Thr Ser Leu Pro Ala Gln Pro Thr Ala 
    690                 695                 700                 


Gln Ser Thr Ser Gln Leu Gln Val Gln Ala Leu Ala Gln Gln Gln Gln 
705                 710                 715                 720 


Ser Pro Thr Lys Val Ile Pro Ala Leu Gly Lys Ser Pro Pro His His 
                725                 730                 735     


Ser Gly Phe Gln Gln Tyr Gln Gln Ala Asp Ala Ser Lys Gln Leu Trp 
            740                 745                 750         


Asn Pro Pro Gln Val Gln Ser Pro Leu Gly Lys Ile Met Pro Val Lys 
        755                 760                 765             


Gln Ser Tyr Tyr Leu Gln Thr Gln Asp Pro Ile Lys Leu Phe Glu Pro 
    770                 775                 780                 


Ser Leu Gln Pro Pro Val Ile Gln Gln Gln Pro Leu Glu Lys Lys Met 
785                 790                 795                 800 


Lys Pro Phe Pro Met Glu Pro Tyr Asn His Asn Pro Ser Glu Val Lys 
                805                 810                 815     


Val Pro Glu Phe Tyr Trp Asp Ser Ser Tyr Ser Met Ala Asp Asn Arg 
            820                 825                 830         


Ala Val Met Ala Gln Gln Pro Asn Met Asp Arg Arg Ser Lys Arg Ser 
        835                 840                 845             


Pro Gly Val Phe Arg Pro Glu Gln Asp Pro Val Pro Arg Met Pro Phe 
    850                 855                 860                 


Glu Asp Pro Lys Ser Ser Pro Leu Leu Pro Pro Asp Leu Leu Lys Ser 
865                 870                 875                 880 


Leu Ala Ala Leu Glu Glu Glu Glu Glu Leu Ile Phe Ser Asn Pro Pro 
                885                 890                 895     


Asp Leu Tyr Pro Ala Leu Leu Gly Pro Leu Ala Ser Leu Pro Gly Arg 
            900                 905                 910         


Ser Leu Phe Lys Ser Leu Leu Glu Lys Pro Ser Glu Leu Met Ser His 
        915                 920                 925             


Ser Ser Ser Phe Leu Ser Leu Thr Gly Phe Ser Val Asn Gln Glu Arg 
    930                 935                 940                 


Tyr Pro Asn Ser Ser Met Phe Asn Glu Val Tyr Gly Lys Asn Leu Thr 
945                 950                 955                 960 


Thr Ser Ser Lys Ala Glu Leu Asn Pro Ser Val Ala Ser Gln Glu Thr 
                965                 970                 975     


Ser Leu Tyr Ser Leu Phe Glu Gly Thr Pro Trp Ser Pro Ser Leu Pro 
            980                 985                 990         


Ala Ser Ser Asp His Ser Thr Pro  Ala Ser Gln Ser Pro  His Ser Ser 
        995                 1000                 1005             


Asn Pro  Ser Ser Leu Pro Ser  Ser Pro Pro Thr His  Asn His Asn 
    1010                 1015                 1020             


Ser Ala  Pro Phe Ser Asn Phe  Gly Pro Ile Gly Thr  Pro Asp Asn 
    1025                 1030                 1035             


Arg Asp  Arg Arg Pro Ala Asp  Arg Trp Lys Thr Asp  Lys Pro Ala 
    1040                 1045                 1050             


Met Gly  Gly Phe Gly Val Asp  Tyr Leu Ser Ala Thr  Ser Ser Ser 
    1055                 1060                 1065             


Glu Ser  Ser Trp His Gln Ala  Ser Thr Pro Ser Gly  Thr Trp Thr 
    1070                 1075                 1080             


Gly His  Gly Pro Ser Met Glu  Asp Ser Ser Ala Val  Leu Met Glu 
    1085                 1090                 1095             


Ser Leu  Lys Ser Ile Trp Ser  Ser Ser Met Met His  Pro Gly Pro 
    1100                 1105                 1110             


Ser Ala  Leu Glu Gln Leu Leu  Met Gln Gln Lys Gln  Lys Gln Gln 
    1115                 1120                 1125             


Arg Gly  Gln Gly Ala Met Asn  Pro Pro His 
    1130                 1135             


<210>  65
<211>  556
<212>  PRT
<213>  Mus musculus

<400>  65

Met Glu Gly Pro Leu Ser Val Phe Gly Asp Arg Ser Thr Gly Glu Ala 
1               5                   10                  15      


Val Arg Ser Gln Asn Val Met Ala Ala Ala Ser Ile Ala Asn Ile Val 
            20                  25                  30          


Lys Ser Ser Phe Gly Pro Val Gly Leu Asp Lys Met Leu Val Asp Asp 
        35                  40                  45              


Ile Gly Asp Val Thr Ile Thr Asn Asp Gly Ala Thr Ile Leu Lys Leu 
    50                  55                  60                  


Leu Glu Val Glu His Pro Ala Ala Lys Val Leu Cys Glu Leu Ala Asp 
65                  70                  75                  80  


Leu Gln Asp Lys Glu Val Gly Asp Gly Thr Thr Ser Val Val Ile Ile 
                85                  90                  95      


Ala Ala Glu Leu Leu Lys Asn Ala Asp Glu Leu Val Lys Gln Lys Ile 
            100                 105                 110         


His Pro Thr Ser Val Ile Ser Gly Tyr Arg Leu Ala Cys Lys Glu Ala 
        115                 120                 125             


Val Arg Tyr Ile Asn Glu Asn Leu Ile Ile Asn Thr Asp Glu Leu Gly 
    130                 135                 140                 


Arg Asp Cys Leu Ile Asn Ala Ala Lys Thr Ser Met Ser Ser Lys Ile 
145                 150                 155                 160 


Ile Gly Ile Asn Gly Asp Tyr Phe Ala Asn Met Val Val Asp Ala Val 
                165                 170                 175     


Leu Ala Val Lys Tyr Thr Asp Ala Arg Gly Gln Pro Arg Tyr Pro Val 
            180                 185                 190         


Asn Ser Val Asn Ile Leu Lys Ala His Gly Arg Ser Gln Ile Glu Ser 
        195                 200                 205             


Met Leu Ile Asn Gly Tyr Ala Leu Asn Cys Val Val Gly Ser Gln Gly 
    210                 215                 220                 


Met Pro Lys Arg Ile Val Asn Ala Lys Ile Ala Cys Leu Asp Phe Ser 
225                 230                 235                 240 


Leu Gln Lys Thr Lys Met Lys Leu Gly Val Gln Val Val Ile Thr Asp 
                245                 250                 255     


Pro Glu Lys Leu Asp Gln Ile Arg Gln Arg Glu Ser Asp Ile Thr Lys 
            260                 265                 270         


Glu Arg Ile Gln Lys Ile Leu Ala Thr Gly Ala Asn Val Ile Leu Thr 
        275                 280                 285             


Thr Gly Gly Ile Asp Asp Met Tyr Leu Lys Tyr Phe Val Glu Ala Gly 
    290                 295                 300                 


Ala Met Ala Val Arg Arg Val Leu Lys Arg Asp Leu Lys His Val Ala 
305                 310                 315                 320 


Lys Ala Ser Gly Ala Ser Ile Leu Ser Thr Leu Ala Asn Leu Glu Gly 
                325                 330                 335     


Glu Glu Thr Phe Glu Val Thr Met Leu Gly Gln Ala Glu Glu Val Val 
            340                 345                 350         


Gln Glu Arg Ile Cys Asp Asp Glu Leu Ile Leu Ile Lys Asn Thr Lys 
        355                 360                 365             


Ala Arg Thr Ser Ala Ser Ile Ile Leu Arg Gly Ala Asn Asp Phe Met 
    370                 375                 380                 


Cys Asp Glu Met Glu Arg Ser Leu His Asp Ala Leu Cys Val Val Lys 
385                 390                 395                 400 


Arg Val Leu Glu Leu Lys Ser Val Val Pro Gly Gly Gly Ala Val Glu 
                405                 410                 415     


Ala Ala Leu Ser Ile Tyr Leu Glu Asn Tyr Ala Thr Ser Met Gly Ser 
            420                 425                 430         


Arg Glu Gln Leu Ala Ile Ala Glu Phe Ala Arg Ser Leu Leu Val Ile 
        435                 440                 445             


Pro Asn Thr Leu Ala Val Asn Ala Ala Gln Asp Ser Thr Asp Leu Val 
    450                 455                 460                 


Ala Lys Leu Arg Ala Phe His Asn Glu Ala Gln Val Asn Pro Glu Arg 
465                 470                 475                 480 


Lys Asn Leu Lys Trp Ile Gly Leu Asp Leu Val His Gly Lys Pro Arg 
                485                 490                 495     


Asp Asn Lys Gln Ala Gly Val Phe Glu Pro Thr Ile Val Lys Val Lys 
            500                 505                 510         


Ser Leu Lys Phe Ala Thr Glu Ala Ala Ile Thr Ile Leu Arg Ile Asp 
        515                 520                 525             


Asp Leu Ile Lys Leu His Pro Glu Ser Lys Asp Asp Lys His Gly Ser 
    530                 535                 540                 


Tyr Glu Asn Ala Val His Ser Gly Ala Leu Asp Asp 
545                 550                 555     


<210>  66
<211>  1051
<212>  PRT
<213>  Mus musculus

<400>  66

Met Glu Val Ala Val Glu Lys Ala Ala Ala Ala Ala Ala Pro Ala Gly 
1               5                   10                  15      


Gly Pro Ala Ala Ala Ala Pro Ser Gly Glu Asn Glu Ala Glu Ser Arg 
            20                  25                  30          


Gln Gly Pro Asp Ser Glu Ser Gly Gly Glu Ala Ser Arg Leu Asn Leu 
        35                  40                  45              


Leu Asp Thr Cys Ala Val Cys His Gln Asn Ile Gln Ser Arg Val Pro 
    50                  55                  60                  


Lys Leu Leu Pro Cys Leu His Ser Phe Cys Gln Arg Cys Leu Pro Ala 
65                  70                  75                  80  


Pro Gln Arg Tyr Leu Met Leu Thr Ala Pro Ala Leu Gly Ser Ala Glu 
                85                  90                  95      


Thr Pro Pro Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Ser Pro Ala 
            100                 105                 110         


Gly Gly Pro Ser Pro Phe Ala Thr Gln Val Gly Val Ile Arg Cys Pro 
        115                 120                 125             


Val Cys Ser Gln Glu Cys Ala Glu Arg His Ile Ile Asp Asn Phe Phe 
    130                 135                 140                 


Val Lys Asp Thr Thr Glu Val Pro Ser Ser Thr Val Glu Lys Ser Asn 
145                 150                 155                 160 


Gln Val Cys Thr Ser Cys Glu Asp Asn Ala Glu Ala Asn Gly Phe Cys 
                165                 170                 175     


Val Glu Cys Val Glu Trp Leu Cys Lys Thr Cys Ile Arg Ala His Gln 
            180                 185                 190         


Arg Val Lys Phe Thr Lys Asp His Thr Val Arg Gln Lys Glu Glu Val 
        195                 200                 205             


Ser Pro Glu Ala Val Gly Val Thr Ser Gln Arg Pro Val Phe Cys Pro 
    210                 215                 220                 


Phe His Lys Lys Glu Gln Leu Lys Leu Tyr Cys Glu Thr Cys Asp Lys 
225                 230                 235                 240 


Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His Lys Glu His Arg Tyr 
                245                 250                 255     


Gln Phe Ile Glu Glu Ala Phe Gln Asn Gln Lys Val Ile Ile Asp Thr 
            260                 265                 270         


Leu Ile Thr Lys Leu Met Glu Lys Thr Lys Tyr Ile Lys Tyr Thr Gly 
        275                 280                 285             


Asn Gln Ile Gln Asn Arg Ile Ile Glu Ile Asn Gln Asn Gln Lys Gln 
    290                 295                 300                 


Val Glu Gln Asp Ile Lys Val Ala Ile Phe Thr Leu Met Val Glu Ile 
305                 310                 315                 320 


Asn Lys Lys Gly Lys Ala Leu Leu His Gln Leu Glu Ser Leu Ala Lys 
                325                 330                 335     


Asp His Arg Met Lys Leu Met Gln Gln Gln Gln Glu Val Ala Gly Leu 
            340                 345                 350         


Ser Lys Gln Leu Glu His Val Met His Phe Ser Lys Trp Ala Val Ser 
        355                 360                 365             


Ser Gly Ser Ser Thr Ala Leu Leu Tyr Ser Lys Arg Leu Ile Thr Tyr 
    370                 375                 380                 


Arg Leu Arg His Leu Leu Arg Ala Arg Cys Asp Ala Ser Pro Val Thr 
385                 390                 395                 400 


Asn Thr Thr Ile Gln Phe His Cys Asp Pro Ser Phe Trp Ala Gln Asn 
                405                 410                 415     


Ile Ile Asn Leu Gly Ser Leu Val Ile Glu Asp Lys Glu Ser Gln Pro 
            420                 425                 430         


Gln Met Pro Lys Gln Asn Pro Val Val Glu Gln Ser Ser Gln Pro Pro 
        435                 440                 445             


Gly Gly Leu Pro Ser Asn Gln Leu Ser Lys Phe Pro Thr Gln Ile Ser 
    450                 455                 460                 


Leu Ala Gln Leu Arg Leu Gln His Ile Gln Gln Gln Val Met Ala Gln 
465                 470                 475                 480 


Arg Gln Gln Val Gln Arg Arg Pro Ala Pro Val Gly Leu Pro Asn Pro 
                485                 490                 495     


Arg Met Gln Gly Pro Ile Gln Gln Pro Ser Ile Ser His Gln His Pro 
            500                 505                 510         


Pro Pro Arg Leu Ile Asn Phe Gln Asn His Ser Pro Lys Pro Asn Gly 
        515                 520                 525             


Pro Val Leu Pro Pro Tyr Pro Gln Gln Leu Arg Tyr Ser Pro Ser Gln 
    530                 535                 540                 


Asn Val Pro Arg Gln Thr Thr Ile Lys Pro Asn Pro Leu Gln Met Ala 
545                 550                 555                 560 


Phe Leu Ala Gln Gln Ala Ile Lys Gln Trp Gln Ile Ser Ser Val Gln 
                565                 570                 575     


Ala Pro Pro Thr Thr Ala Ser Ser Ser Ser Ser Thr Pro Ser Ser Pro 
            580                 585                 590         


Thr Ile Thr Ser Ala Ala Gly Tyr Asp Gly Lys Ala Phe Ser Ser Pro 
        595                 600                 605             


Met Ile Asp Leu Ser Ala Pro Val Gly Gly Ser Tyr Asn Leu Pro Ser 
    610                 615                 620                 


Leu Pro Asp Ile Asp Cys Ser Ser Thr Ile Met Leu Asp Asn Ile Ala 
625                 630                 635                 640 


Arg Lys Asp Thr Gly Val Asp His Ala Gln Pro Arg Pro Pro Ser Asn 
                645                 650                 655     


Arg Thr Val Gln Ser Pro Asn Ser Ser Val Pro Ser Pro Gly Leu Ala 
            660                 665                 670         


Gly Pro Val Thr Met Thr Ser Val His Pro Pro Ile Arg Ser Pro Ser 
        675                 680                 685             


Ala Ser Ser Val Gly Ser Arg Gly Ser Ser Gly Ser Ser Ser Lys Pro 
    690                 695                 700                 


Ala Gly Ala Asp Ser Thr His Lys Val Pro Val Val Met Leu Glu Pro 
705                 710                 715                 720 


Ile Arg Ile Lys Gln Glu Asn Ser Gly Pro Pro Glu Asn Tyr Asp Phe 
                725                 730                 735     


Pro Val Val Ile Val Lys Gln Glu Ser Asp Glu Glu Ser Arg Pro Gln 
            740                 745                 750         


Asn Thr Asn Tyr Pro Arg Ser Ile Leu Thr Ser Leu Leu Leu Asn Ser 
        755                 760                 765             


Ser Gln Ser Ser Ala Ser Glu Glu Thr Val Leu Arg Ser Asp Ala Pro 
    770                 775                 780                 


Asp Ser Thr Gly Asp Gln Pro Gly Leu His Gln Glu Asn Ser Ser Asn 
785                 790                 795                 800 


Gly Lys Ser Glu Trp Ser Asp Ala Ser Gln Lys Ser Pro Val His Val 
                805                 810                 815     


Gly Glu Thr Arg Lys Glu Asp Asp Pro Asn Glu Asp Trp Cys Ala Val 
            820                 825                 830         


Cys Gln Asn Gly Gly Glu Leu Leu Cys Cys Glu Lys Cys Pro Lys Val 
        835                 840                 845             


Phe His Leu Thr Cys His Val Pro Thr Leu Thr Asn Phe Pro Ser Gly 
    850                 855                 860                 


Glu Trp Ile Cys Thr Phe Cys Arg Asp Leu Ser Lys Pro Glu Val Asp 
865                 870                 875                 880 


Tyr Asp Cys Asp Val Pro Ser His His Ser Glu Lys Arg Lys Ser Glu 
                885                 890                 895     


Gly Leu Thr Lys Leu Thr Pro Ile Asp Lys Arg Lys Cys Glu Arg Leu 
            900                 905                 910         


Leu Leu Phe Leu Tyr Cys His Glu Met Ser Leu Ala Phe Gln Asp Pro 
        915                 920                 925             


Val Pro Leu Thr Val Pro Asp Tyr Tyr Lys Ile Ile Lys Asn Pro Met 
    930                 935                 940                 


Asp Leu Ser Thr Ile Lys Lys Arg Leu Gln Glu Asp Tyr Cys Met Tyr 
945                 950                 955                 960 


Thr Lys Pro Glu Asp Phe Val Ala Asp Phe Arg Leu Ile Phe Gln Asn 
                965                 970                 975     


Cys Ala Glu Phe Asn Glu Pro Asp Ser Glu Val Ala Asn Ala Gly Ile 
            980                 985                 990         


Lys Leu Glu Ser Tyr Phe Glu Glu  Leu Leu Lys Asn Leu  Tyr Pro Glu 
        995                 1000                 1005             


Lys Arg  Phe Pro Lys Val Glu  Phe Arg His Glu Ala  Glu Asp Cys 
    1010                 1015                 1020             


Lys Phe  Ser Asp Asp Ser Asp  Asp Asp Phe Val Gln  Pro Arg Lys 
    1025                 1030                 1035             


Lys Arg  Leu Lys Ser Thr Glu  Asp Arg Gln Leu Leu  Lys 
    1040                 1045                 1050     


<210>  67
<211>  445
<212>  PRT
<213>  Mus musculus

<400>  67

Met Arg Glu Ile Val His Leu Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Val 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Gly Glu Phe Glu Glu Glu Ala Glu Glu Glu Val Ala 
        435                 440                 445 


<210>  68
<211>  444
<212>  PRT
<213>  Mus musculus

<400>  68

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Asp Arg Ile Ser 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Val Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Val Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Glu Asp Phe Gly Glu Glu Ala Glu Glu Glu Ala 
        435                 440                 


<210>  69
<211>  467
<212>  PRT
<213>  Mus musculus

<400>  69

Met Ala Ala His Gly Gly Ser Ala Ala Ser Ser Ala Leu Lys Gly Leu 
1               5                   10                  15      


Ile Gln Gln Phe Thr Ala Ile Thr Gly Ala Ser Glu Ser Val Gly Lys 
            20                  25                  30          


His Met Leu Glu Ala Cys Asn Asn Asn Leu Glu Met Ala Val Thr Met 
        35                  40                  45              


Phe Leu Asp Gly Gly Gly Ile Ala Glu Glu Pro Ser Thr Ser Ser Ala 
    50                  55                  60                  


Ser Val Ser Thr Val Arg Pro His Thr Glu Glu Glu Val Arg Ala Pro 
65                  70                  75                  80  


Ile Pro Gln Lys Gln Glu Ile Leu Val Glu Pro Glu Pro Leu Phe Gly 
                85                  90                  95      


Val Arg Gln Glu Gln Glu Leu Arg Asn Gly Gly Ala Ile Asp Lys Lys 
            100                 105                 110         


Leu Thr Thr Leu Ala Asp Leu Phe Arg Pro Pro Ile Asp Leu Met His 
        115                 120                 125             


Lys Gly Ser Phe Glu Thr Ala Lys Glu Cys Gly Gln Met Gln Asn Lys 
    130                 135                 140                 


Trp Leu Met Ile Asn Ile Gln Asn Val Gln Asp Phe Ala Cys Gln Cys 
145                 150                 155                 160 


Leu Asn Arg Asp Val Trp Ser Asn Glu Ala Val Lys Asn Ile Ile Arg 
                165                 170                 175     


Glu His Phe Ile Phe Trp Gln Val Tyr His Asp Ser Glu Glu Gly Gln 
            180                 185                 190         


Arg Tyr Ile Gln Phe Tyr Lys Leu Gly Asp Phe Pro Tyr Val Ser Ile 
        195                 200                 205             


Leu Asp Pro Arg Thr Gly Gln Lys Leu Val Glu Trp His Gln Leu Asp 
    210                 215                 220                 


Val Ser Ser Phe Leu Asp Gln Val Thr Gly Phe Leu Gly Glu His Gly 
225                 230                 235                 240 


Gln Leu Asp Gly Leu Ser Ser Ser Pro Pro Lys Lys Cys Ala Arg Ser 
                245                 250                 255     


Glu Ser Leu Ile Asp Ala Ser Glu Asp Ser Gln Leu Glu Ala Ala Ile 
            260                 265                 270         


Arg Ala Ser Leu Gln Glu Thr His Phe Asp Ser Ala Gln Ala Lys Gln 
        275                 280                 285             


Asp Ser Arg Ser Asp Glu Glu Ser Glu Ser Glu Leu Phe Ser Gly Ser 
    290                 295                 300                 


Glu Glu Phe Ile Ser Val Cys Gly Ser Asp Glu Glu Glu Glu Val Glu 
305                 310                 315                 320 


Asn Leu Ala Lys Ser Arg Lys Ser Pro His Lys Asp Leu Gly His Arg 
                325                 330                 335     


Lys Glu Glu Asn Arg Arg Pro Leu Thr Glu Pro Pro Ala Arg Thr Glu 
            340                 345                 350         


Pro Gly Thr Ala Thr Asn His Gln Gly Leu Pro Ser Met Asp Ser Glu 
        355                 360                 365             


Val Leu Glu Met Ser Pro Glu Lys Ser Asp Gly Ile Val Glu Gly Ile 
    370                 375                 380                 


Asp Val Asn Gly Pro Lys Ala Gln Leu Met Leu Arg Tyr Pro Asp Gly 
385                 390                 395                 400 


Lys Arg Glu Gln Ile Thr Leu Pro Glu Gln Ala Lys Leu Leu Ala Leu 
                405                 410                 415     


Val Lys His Val Gln Ser Lys Gly Tyr Pro Asn Glu Arg Phe Glu Leu 
            420                 425                 430         


Leu Thr Asn Phe Pro Arg Arg Lys Leu Ser His Leu Asp Tyr Asp Ile 
        435                 440                 445             


Thr Leu Gln Glu Ala Gly Leu Cys Pro Gln Glu Thr Val Phe Val Gln 
    450                 455                 460                 


Glu Arg Asn 
465         


<210>  70
<211>  1103
<212>  PRT
<213>  Mus musculus

<400>  70

Met Asn His Gln Gln Gln Gln Gln Gln Gln Gln Lys Ala Gly Glu Gln 
1               5                   10                  15      


Gln Leu Ser Glu Pro Glu Asp Met Glu Met Glu Ala Gly Asp Thr Asp 
            20                  25                  30          


Asp Pro Pro Arg Ile Thr Gln Asn Pro Val Ile Asn Gly Asn Val Thr 
        35                  40                  45              


Leu Ser Asp Gly His Ser Asn Ala Glu Glu Asp Met Glu Asp Asp Thr 
    50                  55                  60                  


Ser Trp Arg Ser Glu Ala Thr Phe Gln Phe Thr Val Glu Arg Phe Ser 
65                  70                  75                  80  


Arg Leu Ser Glu Ser Val Leu Ser Pro Pro Cys Phe Val Arg Asn Leu 
                85                  90                  95      


Pro Trp Lys Ile Met Val Met Pro Arg Phe Tyr Pro Asp Arg Pro His 
            100                 105                 110         


Gln Lys Ser Val Gly Phe Phe Leu Gln Cys Asn Ala Glu Ser Asp Ser 
        115                 120                 125             


Thr Ser Trp Ser Cys His Ala Gln Ala Val Leu Lys Ile Ile Asn Tyr 
    130                 135                 140                 


Arg Asp Asp Asp Lys Ser Phe Ser Arg Arg Ile Ser His Leu Phe Phe 
145                 150                 155                 160 


His Glu Glu Asn Asp Trp Gly Phe Ser Asn Phe Met Ala Trp Ser Glu 
                165                 170                 175     


Val Thr Asp Pro Glu Lys Gly Phe Ile Asp Asp Asp Lys Val Thr Phe 
            180                 185                 190         


Glu Val Phe Val Gln Ala Asp Ala Pro His Gly Val Ala Trp Asp Ser 
        195                 200                 205             


Lys Lys His Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys 
    210                 215                 220                 


Tyr Met Asn Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg 
225                 230                 235                 240 


Lys Ala Val Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser 
                245                 250                 255     


Val Pro Leu Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp 
            260                 265                 270         


Lys Pro Val Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr 
        275                 280                 285             


Leu Asp Ser Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu 
    290                 295                 300                 


Leu Asp Asn Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr 
305                 310                 315                 320 


Ile Pro Lys Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys 
                325                 330                 335     


Asp Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln 
            340                 345                 350         


Leu Ser Ile Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr 
        355                 360                 365             


Val Ala Val Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu 
    370                 375                 380                 


His Gly Leu Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro 
385                 390                 395                 400 


Pro Val Leu His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr 
                405                 410                 415     


Asp Gln Asn Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu 
            420                 425                 430         


Pro Leu Asp Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn 
        435                 440                 445             


Tyr Ile Leu His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly 
    450                 455                 460                 


His Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys 
465                 470                 475                 480 


Phe Asp Asp Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu 
                485                 490                 495     


His Asn Tyr Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr 
            500                 505                 510         


Asn Ala Tyr Met Leu Val Tyr Ile Arg Glu Ser Lys Leu Ser Glu Val 
        515                 520                 525             


Leu Gln Ala Val Thr Asp His Asp Ile Pro Gln Gln Leu Val Glu Arg 
    530                 535                 540                 


Leu Gln Glu Glu Lys Arg Ile Glu Ala Gln Lys Arg Lys Glu Arg Gln 
545                 550                 555                 560 


Glu Ala His Leu Tyr Met Gln Val Gln Ile Val Ala Glu Asp Gln Phe 
                565                 570                 575     


Cys Gly His Gln Gly Asn Asp Met Tyr Asp Glu Glu Lys Val Arg Tyr 
            580                 585                 590         


Thr Val Phe Lys Val Leu Lys Asn Ser Ser Leu Ala Glu Phe Val Gln 
        595                 600                 605             


Ser Leu Ser Gln Thr Met Gly Phe Pro Gln Asp Gln Ile Arg Leu Trp 
    610                 615                 620                 


Pro Met Gln Ala Arg Ser Asn Gly Thr Lys Arg Pro Ala Met Leu Asp 
625                 630                 635                 640 


Asn Glu Ala Asp Gly Asn Lys Thr Met Ile Glu Leu Ser Asp Asn Glu 
                645                 650                 655     


Asn Pro Trp Thr Ile Phe Leu Glu Thr Val Asp Pro Glu Leu Ala Ala 
            660                 665                 670         


Ser Gly Ala Thr Leu Pro Lys Phe Asp Lys Asp His Asp Val Met Leu 
        675                 680                 685             


Phe Leu Lys Met Tyr Asp Pro Lys Thr Arg Ser Leu Asn Tyr Cys Gly 
    690                 695                 700                 


His Ile Tyr Thr Pro Ile Ser Cys Lys Ile Arg Asp Leu Leu Pro Val 
705                 710                 715                 720 


Met Cys Asp Arg Ala Gly Phe Ile Gln Asp Thr Ser Leu Ile Leu Tyr 
                725                 730                 735     


Glu Glu Val Lys Pro Asn Leu Thr Glu Arg Ile Gln Asp Tyr Asp Val 
            740                 745                 750         


Ser Leu Asp Lys Ala Leu Asp Glu Leu Met Asp Gly Asp Ile Ile Val 
        755                 760                 765             


Phe Gln Lys Asp Asp Pro Glu Asn Asp Asn Ser Glu Leu Pro Thr Ala 
    770                 775                 780                 


Lys Glu Tyr Phe Arg Asp Leu Tyr His Arg Val Asp Val Ile Phe Cys 
785                 790                 795                 800 


Asp Lys Thr Ile Pro Asn Asp Pro Gly Phe Val Val Thr Leu Ser Asn 
                805                 810                 815     


Arg Met Asn Tyr Phe Gln Val Ala Lys Thr Val Ala Gln Arg Leu Asn 
            820                 825                 830         


Thr Asp Pro Met Leu Leu Gln Phe Phe Lys Ser Gln Gly Tyr Arg Asp 
        835                 840                 845             


Gly Pro Gly Asn Pro Leu Arg His Asn Tyr Glu Gly Thr Leu Arg Asp 
    850                 855                 860                 


Leu Leu Gln Phe Phe Lys Pro Arg Gln Pro Lys Lys Leu Tyr Tyr Gln 
865                 870                 875                 880 


Gln Leu Lys Met Lys Ile Thr Asp Phe Glu Asn Arg Arg Ser Phe Lys 
                885                 890                 895     


Cys Ile Trp Leu Asn Ser Gln Phe Arg Glu Glu Glu Ile Thr Leu Tyr 
            900                 905                 910         


Pro Asp Lys His Gly Cys Val Arg Asp Leu Leu Glu Glu Cys Lys Lys 
        915                 920                 925             


Ala Val Glu Leu Gly Asp Lys Ala Ser Gly Arg Leu Arg Leu Leu Glu 
    930                 935                 940                 


Ile Val Ser Tyr Lys Ile Ile Gly Val His Gln Glu Asp Glu Leu Leu 
945                 950                 955                 960 


Glu Cys Leu Ser Pro Ala Thr Ser Arg Thr Phe Arg Ile Glu Glu Ile 
                965                 970                 975     


Pro Leu Asp Gln Val Asp Ile Asp Lys Glu Asn Glu Met Leu Ile Thr 
            980                 985                 990         


Val Ala His Phe His Lys Glu Val  Phe Gly Thr Phe Gly  Ile Pro Phe 
        995                 1000                 1005             


Leu Leu  Arg Ile His Gln Gly  Glu His Phe Arg Glu  Val Met Lys 
    1010                 1015                 1020             


Arg Ile  Gln Ser Leu Leu Asp  Ile Gln Glu Lys Glu  Phe Glu Lys 
    1025                 1030                 1035             


Phe Lys  Phe Ala Ile Val Met  Met Gly Arg His Gln  Tyr Ile Asn 
    1040                 1045                 1050             


Glu Asp  Glu Tyr Glu Val Asn  Leu Lys Asp Phe Glu  Pro Gln Pro 
    1055                 1060                 1065             


Gly Asn  Met Ser His Pro Arg  Pro Trp Leu Gly Leu  Asp His Phe 
    1070                 1075                 1080             


Asn Lys  Ala Pro Lys Arg Ser  Arg Tyr Thr Tyr Leu  Glu Lys Ala 
    1085                 1090                 1095             


Ile Lys  Ile His Asn 
    1100             


<210>  71
<211>  2559
<212>  PRT
<213>  Mus musculus

<400>  71

Met Thr Ala Thr Thr Arg Gly Ser Pro Val Gly Gly Asn Asp Asn Gln 
1               5                   10                  15      


Gly Gln Ala Pro Asp Gly Gln Ser Gln Pro Pro Leu Gln Gln Asn Gln 
            20                  25                  30          


Thr Ser Ser Pro Asp Ser Ser Asn Glu Asn Ser Pro Ala Thr Pro Pro 
        35                  40                  45              


Asp Glu Gln Gly Gln Gly Asp Ala Pro Pro Gln Ile Glu Asp Glu Glu 
    50                  55                  60                  


Pro Ala Phe Pro His Thr Asp Leu Ala Lys Leu Asp Asp Met Ile Asn 
65                  70                  75                  80  


Arg Pro Arg Trp Val Val Pro Val Leu Pro Lys Gly Glu Leu Glu Val 
                85                  90                  95      


Leu Leu Glu Ala Ala Ile Asp Leu Ser Lys Lys Gly Leu Asp Val Lys 
            100                 105                 110         


Ser Glu Ala Cys Gln Arg Phe Phe Arg Asp Gly Leu Thr Ile Ser Phe 
        115                 120                 125             


Thr Lys Ile Leu Thr Asp Glu Ala Val Ser Gly Trp Lys Phe Glu Ile 
    130                 135                 140                 


His Arg Cys Ile Ile Asn Asn Thr His Arg Leu Val Glu Leu Cys Val 
145                 150                 155                 160 


Ala Lys Leu Ala Gln Asp Trp Phe Pro Leu Leu Glu Leu Leu Ala Met 
                165                 170                 175     


Ala Leu Asn Pro His Cys Lys Phe His Ile Tyr Asn Gly Thr Arg Pro 
            180                 185                 190         


Cys Glu Ser Val Ser Ser Ser Val Gln Leu Pro Glu Asp Glu Leu Phe 
        195                 200                 205             


Ala Arg Ser Pro Asp Pro Arg Ser Pro Lys Gly Trp Leu Val Asp Leu 
    210                 215                 220                 


Leu Asn Lys Phe Gly Thr Leu Asn Gly Phe Gln Ile Leu His Asp Arg 
225                 230                 235                 240 


Phe Ile Asn Gly Ser Ala Leu Asn Val Gln Ile Ile Ala Ala Leu Ile 
                245                 250                 255     


Lys Pro Phe Gly Gln Cys Tyr Glu Phe Leu Thr Leu His Thr Val Lys 
            260                 265                 270         


Lys Tyr Phe Leu Pro Ile Ile Glu Met Val Pro Gln Phe Leu Glu Asn 
        275                 280                 285             


Leu Thr Asp Glu Glu Leu Lys Lys Glu Ala Lys Asn Glu Ala Lys Asn 
    290                 295                 300                 


Asp Ala Leu Ser Met Ile Ile Lys Ser Leu Lys Asn Leu Ala Ser Arg 
305                 310                 315                 320 


Val Pro Gly Gln Glu Glu Thr Val Lys Asn Leu Glu Ile Phe Arg Leu 
                325                 330                 335     


Lys Met Ile Leu Arg Leu Leu Gln Ile Ser Ser Phe Asn Gly Lys Met 
            340                 345                 350         


Asn Ala Leu Asn Glu Val Asn Lys Val Ile Ser Ser Val Ser Tyr Tyr 
        355                 360                 365             


Thr His Arg His Gly Ser Ser Glu Asp Glu Glu Trp Leu Thr Ala Glu 
    370                 375                 380                 


Arg Met Ala Glu Trp Ile Gln Gln Asn Asn Ile Leu Ser Ile Val Leu 
385                 390                 395                 400 


Arg Asp Ser Leu His Gln Pro Gln Tyr Val Glu Lys Leu Glu Lys Ile 
                405                 410                 415     


Leu Arg Phe Val Ile Lys Glu Lys Ala Leu Thr Leu Gln Asp Leu Asp 
            420                 425                 430         


Asn Ile Trp Ala Ala Gln Ala Gly Lys His Glu Ala Ile Val Lys Asn 
        435                 440                 445             


Val His Asp Leu Leu Ala Lys Leu Ala Trp Asp Phe Ser Pro Glu Gln 
    450                 455                 460                 


Leu Asp His Leu Phe Asp Cys Phe Lys Ala Ser Trp Thr Asn Ala Ser 
465                 470                 475                 480 


Lys Lys Gln Arg Glu Lys Leu Leu Glu Leu Ile Arg Arg Leu Ala Glu 
                485                 490                 495     


Asp Asp Lys Asp Gly Val Met Ala His Lys Val Leu Asn Leu Leu Trp 
            500                 505                 510         


Asn Leu Ala His Ser Asp Asp Val Pro Val Asp Ile Met Asp Leu Ala 
        515                 520                 525             


Leu Ser Ala His Ile Lys Ile Leu Asp Tyr Ser Cys Ser Gln Asp Arg 
    530                 535                 540                 


Asp Thr Gln Lys Ile Gln Trp Ile Asp Arg Phe Ile Glu Glu Leu Arg 
545                 550                 555                 560 


Thr Asn Asp Lys Trp Val Ile Pro Ala Leu Lys Gln Ile Arg Glu Ile 
                565                 570                 575     


Cys Ser Leu Phe Gly Glu Ala Pro Gln Asn Leu Ser Gln Ser Gln Arg 
            580                 585                 590         


Ser Pro His Val Phe Tyr Arg His Asp Leu Ile Asn Gln Leu Gln His 
        595                 600                 605             


Asn His Ala Leu Val Thr Leu Val Ala Glu Asn Leu Ala Thr Tyr Met 
    610                 615                 620                 


Glu Ser Met Arg Met Tyr Gly Arg Asp Asn Glu Asp Tyr Asp Pro Gln 
625                 630                 635                 640 


Thr Val Arg Leu Gly Ser Arg Tyr Ser His Val Gln Glu Val Gln Glu 
                645                 650                 655     


Arg Leu Asn Phe Leu Arg Phe Leu Leu Lys Asp Gly Gln Leu Trp Leu 
            660                 665                 670         


Cys Ala Pro Gln Ala Lys Gln Ile Trp Lys Cys Leu Ala Glu Asn Ala 
        675                 680                 685             


Val Tyr Leu Cys Asp Arg Glu Ala Cys Phe Lys Trp Tyr Ser Lys Leu 
    690                 695                 700                 


Met Gly Asp Glu Pro Asp Leu Asp Pro Asp Ile Asn Lys Asp Phe Phe 
705                 710                 715                 720 


Glu Ser Asn Val Leu Gln Leu Asp Pro Ser Leu Leu Thr Glu Asn Gly 
                725                 730                 735     


Met Lys Cys Phe Glu Arg Phe Phe Lys Ala Val Asn Cys Arg Glu Gly 
            740                 745                 750         


Lys Leu Val Ala Lys Arg Arg Ala Tyr Met Met Asp Asp Leu Glu Leu 
        755                 760                 765             


Ile Gly Leu Asp Tyr Leu Trp Arg Val Val Ile Gln Ser Asn Asp Asp 
    770                 775                 780                 


Ile Ala Cys Arg Ala Ile Asp Leu Leu Lys Glu Ile Tyr Thr Asn Leu 
785                 790                 795                 800 


Gly Pro Arg Leu Gln Val Asn Gln Val Val Ile His Glu Asp Phe Ile 
                805                 810                 815     


Gln Ser Cys Phe Asp Arg Leu Lys Ala Ser Tyr Asp Thr Leu Cys Val 
            820                 825                 830         


Leu Asp Gly Asp Lys Asp Ser Ile Asn Cys Ala Arg Gln Glu Ala Val 
        835                 840                 845             


Arg Met Val Arg Val Leu Thr Val Leu Arg Glu Tyr Ile Asn Glu Cys 
    850                 855                 860                 


Asp Ser Asp Tyr His Glu Glu Arg Thr Ile Leu Pro Met Ser Arg Ala 
865                 870                 875                 880 


Phe Arg Gly Lys His Leu Ser Phe Ile Val Arg Phe Pro Asn Gln Gly 
                885                 890                 895     


Arg Gln Val Asp Asp Leu Glu Val Trp Ser His Thr Asn Asp Thr Ile 
            900                 905                 910         


Gly Ser Val Arg Arg Cys Ile Leu Asn Arg Ile Lys Ala Asn Val Ala 
        915                 920                 925             


His Thr Lys Ile Glu Leu Phe Val Gly Gly Glu Leu Ile Asp Pro Gly 
    930                 935                 940                 


Asp Asp Arg Lys Leu Ile Gly Gln Leu Asn Leu Lys Asp Lys Ser Leu 
945                 950                 955                 960 


Ile Thr Ala Lys Leu Thr Gln Ile Ser Ser Asn Met Pro Ser Ser Pro 
                965                 970                 975     


Asp Ser Ser Ser Asp Ser Ser Thr Gly Ser Pro Gly Asn His Gly Asn 
            980                 985                 990         


His Tyr Ser Asp Gly Pro Asn Pro  Glu Val Glu Ser Cys  Leu Pro Gly 
        995                 1000                 1005             


Val Ile  Met Ser Leu His Pro  Arg Tyr Ile Ser Phe  Leu Trp Gln 
    1010                 1015                 1020             


Val Ala  Asp Leu Gly Ser Ser  Leu Asn Met Pro Pro  Leu Arg Asp 
    1025                 1030                 1035             


Gly Ala  Arg Val Leu Met Lys  Leu Met Pro Pro Asp  Ser Thr Thr 
    1040                 1045                 1050             


Ile Glu  Lys Leu Arg Ala Ile  Cys Leu Asp His Ala  Lys Leu Gly 
    1055                 1060                 1065             


Glu Ser  Ser Leu Ser Pro Ser  Leu Asp Ser Leu Phe  Phe Gly Pro 
    1070                 1075                 1080             


Ser Ala  Ser Gln Val Leu Tyr  Leu Thr Glu Val Val  Tyr Ala Leu 
    1085                 1090                 1095             


Leu Met  Pro Ala Gly Ala Pro  Leu Thr Asp Asp Ser  Ser Asp Phe 
    1100                 1105                 1110             


Gln Phe  His Phe Leu Lys Ser  Gly Gly Leu Pro Leu  Val Leu Ser 
    1115                 1120                 1125             


Met Leu  Thr Arg Asn Asn Phe  Leu Pro Asn Ala Asp  Met Glu Thr 
    1130                 1135                 1140             


Arg Arg  Gly Ala Tyr Leu Asn  Ala Leu Lys Ile Ala  Lys Leu Leu 
    1145                 1150                 1155             


Leu Thr  Ala Ile Gly Tyr Gly  His Val Arg Ala Val  Ala Glu Ala 
    1160                 1165                 1170             


Cys Gln  Pro Gly Val Glu Gly  Val Asn Pro Met Thr  Ser Val Asn 
    1175                 1180                 1185             


Gln Val  Thr His Asp Gln Ala  Val Val Leu Gln Ser  Ala Leu Gln 
    1190                 1195                 1200             


Ser Ile  Pro Asn Pro Ser Ser  Glu Cys Met Leu Arg  Asn Val Ser 
    1205                 1210                 1215             


Val Arg  Leu Ala Gln Gln Ile  Ser Asp Glu Ala Ser  Arg Tyr Met 
    1220                 1225                 1230             


Pro Asp  Ile Cys Val Ile Arg  Ala Ile Gln Lys Ile  Ile Trp Thr 
    1235                 1240                 1245             


Ser Gly  Cys Gly Gly Leu Gln  Leu Val Phe Ser Pro  Asn Glu Glu 
    1250                 1255                 1260             


Val Thr  Lys Ile Tyr Glu Lys  Thr Asn Ala Gly Asn  Glu Pro Asp 
    1265                 1270                 1275             


Leu Glu  Asp Glu Gln Val Cys  Cys Glu Ala Leu Glu  Val Met Thr 
    1280                 1285                 1290             


Leu Cys  Phe Ala Leu Ile Pro  Thr Ala Leu Asp Ala  Leu Ser Lys 
    1295                 1300                 1305             


Glu Lys  Ala Trp Gln Thr Phe  Ile Ile Asp Leu Leu  Leu His Cys 
    1310                 1315                 1320             


His Ser  Lys Thr Val Arg Gln  Val Ala Gln Glu Gln  Phe Phe Leu 
    1325                 1330                 1335             


Met Cys  Thr Arg Cys Cys Met  Gly His Arg Pro Leu  Leu Phe Phe 
    1340                 1345                 1350             


Ile Thr  Leu Leu Phe Thr Val  Leu Gly Ser Thr Ala  Arg Glu Arg 
    1355                 1360                 1365             


Ala Lys  His Ser Gly Asp Tyr  Phe Thr Leu Leu Arg  His Leu Leu 
    1370                 1375                 1380             


Asn Tyr  Ala Tyr Asn Ser Asn  Ile Asn Val Pro Asn  Ala Glu Val 
    1385                 1390                 1395             


Leu Leu  Asn Asn Glu Ile Asp  Trp Leu Lys Arg Ile  Arg Asp Asp 
    1400                 1405                 1410             


Val Lys  Arg Thr Gly Glu Thr  Gly Val Glu Glu Thr  Ile Leu Glu 
    1415                 1420                 1425             


Gly His  Leu Gly Val Thr Lys  Glu Leu Leu Ala Phe  Gln Thr Pro 
    1430                 1435                 1440             


Glu Lys  Lys Phe His Ile Gly  Cys Glu Lys Gly Gly  Ala Asn Leu 
    1445                 1450                 1455             


Ile Lys  Glu Leu Ile Asp Asp  Phe Ile Phe Pro Ala  Ser Asn Val 
    1460                 1465                 1470             


Tyr Leu  Gln Tyr Met Arg Asn  Gly Glu Leu Pro Ala  Glu Gln Ala 
    1475                 1480                 1485             


Ile Pro  Val Cys Gly Ser Pro  Ala Thr Ile Asn Ala  Gly Phe Glu 
    1490                 1495                 1500             


Leu Leu  Val Ala Leu Ala Val  Gly Cys Val Arg Asn  Leu Lys Gln 
    1505                 1510                 1515             


Ile Val  Asp Ser Leu Thr Glu  Met Tyr Tyr Ile Gly  Thr Ala Ile 
    1520                 1525                 1530             


Thr Thr  Cys Glu Ala Leu Thr  Glu Trp Glu Tyr Leu  Pro Pro Val 
    1535                 1540                 1545             


Gly Pro  Arg Pro Pro Lys Gly  Phe Val Gly Leu Lys  Asn Ala Gly 
    1550                 1555                 1560             


Ala Thr  Cys Tyr Met Asn Ser  Val Ile Gln Gln Leu  Tyr Met Ile 
    1565                 1570                 1575             


Pro Ser  Ile Arg Asn Gly Ile  Leu Ala Ile Glu Gly  Thr Gly Ser 
    1580                 1585                 1590             


Asp Val  Asp Asp Asp Met Ser  Gly Asp Glu Lys Gln  Asp Asn Glu 
    1595                 1600                 1605             


Ser Asn  Val Asp Pro Arg Asp  Asp Val Phe Gly Tyr  Pro Gln Gln 
    1610                 1615                 1620             


Phe Glu  Asp Lys Pro Pro Leu  Ser Lys Thr Glu Asp  Arg Lys Glu 
    1625                 1630                 1635             


Tyr Asn  Ile Gly Val Leu Arg  His Leu Gln Val Ile  Phe Gly His 
    1640                 1645                 1650             


Leu Ala  Ala Ser Arg Leu Gln  Tyr Tyr Val Pro Arg  Gly Phe Trp 
    1655                 1660                 1665             


Lys Gln  Phe Arg Leu Trp Gly  Glu Pro Val Asn Leu  Arg Glu Gln 
    1670                 1675                 1680             


His Asp  Ala Leu Glu Phe Phe  Asn Ser Leu Val Asp  Ser Leu Asp 
    1685                 1690                 1695             


Glu Ala  Leu Lys Ala Leu Gly  His Pro Ala Met Leu  Ser Lys Val 
    1700                 1705                 1710             


Leu Gly  Gly Ser Phe Ala Asp  Gln Lys Ile Cys Gln  Gly Cys Pro 
    1715                 1720                 1725             


His Arg  Tyr Glu Cys Glu Glu  Ser Phe Thr Thr Leu  Asn Val Asp 
    1730                 1735                 1740             


Ile Arg  Asn His Gln Asn Leu  Leu Asp Ser Leu Glu  Gln Tyr Val 
    1745                 1750                 1755             


Lys Gly  Asp Leu Leu Glu Gly  Ala Asn Ala Tyr His  Cys Glu Lys 
    1760                 1765                 1770             


Cys Asn  Lys Lys Val Asp Thr  Val Lys Arg Leu Leu  Ile Lys Lys 
    1775                 1780                 1785             


Leu Pro  Pro Val Leu Ala Ile  Gln Leu Lys Arg Phe  Asp Tyr Asp 
    1790                 1795                 1800             


Trp Glu  Arg Glu Cys Ala Ile  Lys Phe Asn Asp Tyr  Phe Glu Phe 
    1805                 1810                 1815             


Pro Arg  Glu Leu Asp Met Glu  Pro Tyr Thr Val Ala  Gly Val Ala 
    1820                 1825                 1830             


Lys Leu  Glu Gly Asp Asn Val  Asn Pro Glu Ser Gln  Leu Ile Gln 
    1835                 1840                 1845             


Gln Asn  Glu Gln Ser Glu Ser  Glu Lys Ala Gly Ser  Thr Lys Tyr 
    1850                 1855                 1860             


Arg Leu  Val Gly Val Leu Val  His Ser Gly Gln Ala  Ser Gly Gly 
    1865                 1870                 1875             


His Tyr  Tyr Ser Tyr Ile Ile  Gln Arg Asn Gly Gly  Asp Gly Glu 
    1880                 1885                 1890             


Lys Asn  Arg Trp Tyr Lys Phe  Asp Asp Gly Asp Val  Thr Glu Cys 
    1895                 1900                 1905             


Lys Met  Asp Asp Asp Glu Glu  Met Lys Asn Gln Cys  Phe Gly Gly 
    1910                 1915                 1920             


Glu Tyr  Met Gly Glu Val Phe  Asp His Met Met Lys  Arg Met Ser 
    1925                 1930                 1935             


Tyr Arg  Arg Gln Lys Arg Trp  Trp Asn Ala Tyr Ile  Leu Phe Tyr 
    1940                 1945                 1950             


Glu Arg  Met Asp Thr Ile Gly  His Asp Asp Glu Val  Ile Arg Tyr 
    1955                 1960                 1965             


Ile Ser  Glu Ile Ala Ile Thr  Thr Arg Pro His Gln  Ile Val Met 
    1970                 1975                 1980             


Pro Ser  Ala Ile Glu Arg Ser  Val Arg Lys Gln Asn  Val Gln Phe 
    1985                 1990                 1995             


Met His  Asn Arg Met Gln Tyr  Ser Leu Glu Tyr Phe  Gln Phe Met 
    2000                 2005                 2010             


Lys Lys  Leu Leu Thr Cys Asn  Gly Val Tyr Leu Asn  Pro Pro Pro 
    2015                 2020                 2025             


Gly Gln  Asp His Leu Ser Pro  Glu Ala Glu Glu Ile  Thr Met Ile 
    2030                 2035                 2040             


Ser Ile  Gln Leu Ala Ala Arg  Phe Leu Phe Thr Thr  Gly Phe His 
    2045                 2050                 2055             


Thr Lys  Lys Ile Val Arg Gly  Ser Ala Ser Asp Trp  Tyr Asp Ala 
    2060                 2065                 2070             


Leu Cys  Ile Leu Leu Arg His  Ser Lys Asn Val Arg  Phe Trp Phe 
    2075                 2080                 2085             


Ala His  Asn Val Leu Phe Asn  Val Ser Asn Arg Phe  Ser Glu Tyr 
    2090                 2095                 2100             


Leu Leu  Glu Cys Pro Ser Ala  Glu Val Arg Gly Ala  Phe Ala Lys 
    2105                 2110                 2115             


Leu Ile  Val Phe Ile Ala His  Phe Ser Leu Gln Asp  Gly Pro Cys 
    2120                 2125                 2130             


Pro Ser  Pro Phe Ala Ser Pro  Gly Pro Ser Ser Gln  Ala Tyr Asp 
    2135                 2140                 2145             


Asn Leu  Ser Leu Ser Asp His  Leu Leu Arg Ala Val  Leu Asn Leu 
    2150                 2155                 2160             


Leu Arg  Arg Glu Val Ser Glu  His Gly Arg His Leu  Gln Gln Tyr 
    2165                 2170                 2175             


Phe Asn  Leu Phe Val Met Tyr  Ala Asn Leu Gly Val  Ala Glu Lys 
    2180                 2185                 2190             


Thr Gln  Leu Leu Lys Leu Ser  Val Pro Ala Thr Phe  Met Leu Val 
    2195                 2200                 2205             


Ser Leu  Asp Glu Gly Pro Gly  Pro Pro Ile Lys Tyr  Gln Tyr Ala 
    2210                 2215                 2220             


Glu Leu  Gly Lys Leu Tyr Ser  Val Val Ser Gln Leu  Ile Arg Cys 
    2225                 2230                 2235             


Cys Asn  Val Ser Ser Arg Met  Gln Ser Ser Ile Asn  Gly Asn Pro 
    2240                 2245                 2250             


Ser Leu  Pro Asn Pro Phe Gly  Asp Pro Asn Leu Ser  Gln Pro Ile 
    2255                 2260                 2265             


Met Pro  Ile Gln Gln Asn Val  Val Asp Ile Leu Phe  Val Arg Thr 
    2270                 2275                 2280             


Ser Tyr  Val Lys Lys Ile Ile  Glu Asp Cys Ser Asn  Ser Asp Glu 
    2285                 2290                 2295             


Thr Val  Lys Leu Leu Arg Phe  Cys Cys Trp Glu Asn  Pro Gln Phe 
    2300                 2305                 2310             


Ser Ser  Thr Val Leu Ser Glu  Leu Leu Trp Gln Val  Ala Tyr Ser 
    2315                 2320                 2325             


Tyr Thr  Tyr Glu Leu Arg Pro  Tyr Leu Asp Leu Leu  Leu Gln Ile 
    2330                 2335                 2340             


Leu Leu  Ile Glu Asp Ser Trp  Gln Thr His Arg Ile  His Asn Ala 
    2345                 2350                 2355             


Leu Lys  Gly Ile Pro Asp Asp  Arg Asp Gly Leu Phe  Asp Thr Ile 
    2360                 2365                 2370             


Gln Arg  Ser Lys Asn His Tyr  Gln Lys Arg Ala Tyr  Gln Cys Ile 
    2375                 2380                 2385             


Lys Cys  Met Val Ala Leu Phe  Ser Ser Cys Pro Val  Ala Tyr Gln 
    2390                 2395                 2400             


Ile Leu  Gln Gly Asn Gly Asp  Leu Lys Arg Lys Trp  Thr Trp Ala 
    2405                 2410                 2415             


Val Glu  Trp Leu Gly Asp Glu  Leu Glu Arg Arg Pro  Tyr Thr Gly 
    2420                 2425                 2430             


Asn Pro  Gln Tyr Thr Tyr Asn  Asn Trp Ser Pro Pro  Val Gln Ser 
    2435                 2440                 2445             


Asn Glu  Thr Ser Asn Gly Tyr  Phe Leu Glu Arg Ser  His Ser Ala 
    2450                 2455                 2460             


Arg Met  Thr Leu Ala Lys Ala  Cys Glu Leu Cys Pro  Glu Glu Glu 
    2465                 2470                 2475             


Pro Asp  Asp Gln Asp Ala Pro  Asp Glu His Glu Ser  Pro Pro Pro 
    2480                 2485                 2490             


Glu Asp  Ala Pro Leu Tyr Pro  His Ser Pro Gly Ser  Gln Tyr Gln 
    2495                 2500                 2505             


Gln Asn  Asn His Val His Gly  Gln Pro Tyr Thr Gly  Pro Ala Ala 
    2510                 2515                 2520             


His His  Met Asn Asn Pro Gln  Arg Thr Gly Gln Arg  Ala Gln Glu 
    2525                 2530                 2535             


Asn Tyr  Glu Gly Gly Glu Glu  Val Ser Pro Pro Gln  Thr Lys Gly 
    2540                 2545                 2550             


Ser Val  Lys Cys Thr Tyr 
    2555                 


<210>  72
<211>  245
<212>  PRT
<213>  Mus musculus

<400>  72

Met Glu Lys Thr Glu Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Asp Asp Met Ala Thr Cys Met Lys Ala Val Thr Glu Gln 
            20                  25                  30          


Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Gly Arg Arg Ser Ala Trp Arg Val Ile Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Thr Asp Thr Ser Asp Lys Lys Leu Gln Leu Ile Lys 
65                  70                  75                  80  


Asp Tyr Arg Glu Lys Val Glu Ser Glu Leu Arg Ser Ile Cys Thr Thr 
                85                  90                  95      


Val Leu Glu Leu Leu Asp Lys Tyr Leu Ile Ala Asn Ala Thr Asn Pro 
            100                 105                 110         


Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Phe Arg Tyr 
        115                 120                 125             


Leu Ala Glu Val Ala Cys Gly Asp Asp Arg Lys Gln Thr Ile Glu Asn 
    130                 135                 140                 


Ser Gln Gly Ala Tyr Gln Glu Ala Phe Asp Ile Ser Lys Lys Glu Met 
145                 150                 155                 160 


Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                165                 170                 175     


Phe Tyr Tyr Glu Ile Leu Asn Asn Pro Glu Leu Ala Cys Thr Leu Ala 
            180                 185                 190         


Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Asn Glu 
        195                 200                 205             


Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
    210                 215                 220                 


Leu Thr Leu Trp Thr Ser Asp Ser Ala Gly Glu Glu Cys Asp Ala Ala 
225                 230                 235                 240 


Glu Gly Ala Glu Asn 
                245 


