                         SEQUENCE LISTING

<110>  Development Center for Biotechnology
       DCB-USA LLC
       Chang Gung Memorial Hospital
 
<120>  METHODS FOR SUPPRESSING CANCER BY INHIBITION OF TMCC3

<130>  17787/018WO1

<140>  14/223,800
<141>  2014-03-24

<150>  61/804,751
<151>  2013-03-24

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Gly Ser Asp Thr Ala Leu Thr Val Asp Arg Thr Tyr Ser Tyr 
1               5                   10                  15      


Pro Gly Arg His His Arg Cys Lys Ser Arg Val Glu Arg His Asp Met 
            20                  25                  30          


Asn Thr Leu Ser Leu Pro Leu Asn Ile Arg Arg Gly Gly Ser Asp Thr 
        35                  40                  45              


Asn Leu Asn Phe Asp Val Pro Asp Gly Ile Leu Asp Phe His Lys Val 
    50                  55                  60                  


Lys Leu Thr Ala Asp Ser Leu Lys Gln Lys Ile Leu Lys Val Thr Glu 
65                  70                  75                  80  


Gln Ile Lys Ile Glu Gln Thr Ser Arg Asp Gly Asn Val Ala Glu Tyr 
                85                  90                  95      


Leu Lys Leu Val Asn Asn Ala Asp Lys Gln Gln Ala Gly Arg Ile Lys 
            100                 105                 110         


Gln Val Phe Glu Lys Lys Asn Gln Lys Ser Ala His Ser Ile Ala Gln 
        115                 120                 125             


Leu Gln Lys Lys Leu Glu Gln Tyr His Arg Lys Leu Arg Glu Ile Glu 
    130                 135                 140                 


Gln Asn Gly Ala Ser Arg Ser Ser Lys Asp Ile Ser Lys Asp His Leu 
145                 150                 155                 160 


Lys Asp Ile His Arg Ser Leu Lys Asp Ala His Val Lys Ser Arg Thr 
                165                 170                 175     


Ala Pro His Cys Met Glu Ser Ser Lys Ser Gly Met Pro Gly Val Ser 
            180                 185                 190         


Leu Thr Pro Pro Val Phe Val Phe Asn Lys Ser Arg Glu Phe Ala Asn 
        195                 200                 205             


Leu Ile Arg Asn Lys Phe Gly Ser Ala Asp Asn Ile Ala His Leu Lys 
    210                 215                 220                 


Asn Ser Leu Glu Glu Phe Arg Pro Glu Ala Ser Ala Arg Ala Tyr Gly 
225                 230                 235                 240 


Gly Ser Ala Thr Ile Val Asn Lys Pro Lys Tyr Gly Ser Asp Asp Glu 
                245                 250                 255     


Cys Ser Ser Gly Thr Ser Gly Ser Ala Asp Ser Asn Gly Asn Gln Ser 
            260                 265                 270         


Phe Gly Ala Gly Gly Ala Ser Thr Leu Asp Ser Gln Gly Lys Leu Ala 
        275                 280                 285             


Val Ile Leu Glu Glu Leu Arg Glu Ile Lys Asp Thr Gln Ala Gln Leu 
    290                 295                 300                 


Ala Glu Asp Ile Glu Ala Leu Lys Val Gln Phe Lys Arg Glu Tyr Gly 
305                 310                 315                 320 


Phe Ile Ser Gln Thr Leu Gln Glu Glu Arg Tyr Arg Tyr Glu Arg Leu 
                325                 330                 335     


Glu Asp Gln Leu His Asp Leu Thr Asp Leu His Gln His Glu Thr Ala 
            340                 345                 350         


Asn Leu Lys Gln Glu Leu Ala Ser Ile Glu Glu Lys Val Ala Tyr Gln 
        355                 360                 365             


Ala Tyr Glu Arg Ser Arg Asp Ile Gln Glu Ala Leu Glu Ser Cys Gln 
    370                 375                 380                 


Thr Arg Ile Ser Lys Leu Glu Leu His Gln Gln Glu Gln Gln Ala Leu 
385                 390                 395                 400 


Gln Thr Asp Thr Val Asn Ala Lys Val Leu Leu Gly Arg Cys Ile Asn 
                405                 410                 415     


Val Ile Leu Ala Phe Met Thr Val Ile Leu Val Cys Val Ser Thr Ile 
            420                 425                 430         


Ala Lys Phe Val Ser Pro Met Met Lys Ser Arg Cys His Ile Leu Gly 
        435                 440                 445             


Thr Phe Phe Ala Val Thr Leu Leu Ala Ile Phe Cys Lys Asn Trp Asp 
    450                 455                 460                 


His Ile Leu Cys Ala Ile Glu Arg Met Ile Ile Pro Arg 
465                 470                 475         


<210>  2
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  2

Val Asn Lys Pro Lys Tyr Gly Ser Asp Asp Glu Cys Ser Ser Gly Thr 
1               5                   10                  15      


Ser Gly Ser Ala Asp Ser Asn Gly Asn Gln Ser Phe Gly Ala Gly Gly 
            20                  25                  30          


Ala Ser Thr Leu Asp Ser Gln Gly Lys Leu Ala Val Ile 
        35                  40                  45  


<210>  3
<211>  5867
<212>  DNA
<213>  Homo sapiens

<400>  3
agctgcagca gccgcgccgc cccctcgccc gcggctccca gggtgatccc gagcacagcc       60

ggtggctcgc ggcgcggcag ccccagaaga cgggaaagtt cgcggccgga gcgcggagat      120

gccgggcagc gacacggcgc tcaccgtgga ccggacctac tcggaccccg gccggcacca      180

ccgctgcaag agccgggtag aacgtcatga catgaatacc ttaagcctgc ccctgaacat      240

acgccgaggg gggtcagaca ccaacctcaa ctttgatgtc ccggatggca tcctggactt      300

ccacaaggtc aaactcactg cagacagcct gaagcaaaaa attctaaagg taacagagca      360

gataaaaatt gagcaaacat cgcgcgatgg gaatgttgcg gagtatctga aactagtgaa      420

caacgcagac aagcagcagg cgggacgtat caagcaagtc tttgagaaga agaatcagaa      480

atcagctcac tccatcgccc agctgcagaa gaagttagag cagtatcatc gaaagctcag      540

agagatcgag cagaatggag cctctaggag ctcaaaggac atttccaaag accacctgaa      600

ggatatacat cgctctttga aagatgccca cgtgaaatct cgaactgccc cccattgcat      660

ggagagcagc aaatcgggca tgccaggggt ctcacttact ccacctgtgt tcgttttcaa      720

taagtccaga gagtttgcca acctgatccg gaataagttt ggcagcgccg acaacattgc      780

tcacttgaaa aattccttag aggagtttag gccagaggcg agtgccaggg cctacggggg      840

cagcgctacc atcgtgaaca aacccaagta tggcagtgat gatgaatgtt cgagtggcac      900

gtcaggctcg gccgacagta acggaaacca gtcgtttggg gctggtggag ccagcacact      960

ggacagccag ggcaagctcg ccgtgatcct ggaggaactg agggagatca aggataccca     1020

agctcagctg gctgaggaca tcgaggcact gaaggtgcag tttaagagag aatatggttt     1080

tatttctcag accctgcaag aggaaagata caggtatgag cgactggagg accagctgca     1140

tgacctgacg gacctgcatc agcatgagac agccaacctg aagcaggagc tggccagcat     1200

tgaggagaag gtggcctacc aggcctacga gcgctcgcgg gacatccagg aagccttgga     1260

atcctgccag actcgcattt ctaagctgga gctccaccag caagagcagc aagctctgca     1320

gacagacacc gtgaatgcta aagttctcct ggggaggtgc atcaacgtga tcctggcctt     1380

catgactgtc atcttagtgt gtgtgtccac catcgcgaag ttcgtctcac ccatgatgaa     1440

gagtcgctgc cacattcttg gcaccttctt tgccgtgact cttcttgcta tattttgtaa     1500

aaactgggac catatcctgt gtgccataga aaggatgata ataccaagat gaagccactg     1560

gttcctgcct tcaagttctt tcaagttttt attttaaaga aaactctgtg catactacca     1620

aattttacag tgaatgattg tgcggactcg tgtgtaagaa aaactaggac tgtgtggtgt     1680

aaataactac aattctctta actccgtagc agttgccaac tcagtccttg tacttcgtta     1740

acacgaatct gtttcagagc tctcctacct tgctcactgc cttaatcaga ccgatttcct     1800

gcccacctga ccagcccagc gtggtaaacc tctgtatatt gagaccttgg cataattggt     1860

gatcctgaag aaagaggtct ctctcctaag tctctgtcag aattgagctt cacaattgct     1920

aatggttgtt ttctgtgagt cctataaaaa gcaaggatat gcatgattca gggaatgaag     1980

aatcacaggc ttgggcagtg ttaaacactg tggcctatgg tccccgtgtg atccaccctg     2040

cttctctcca ggggaccata ggtcccgtca tgtactcagt gtccacagca gtcagtcgtg     2100

tatgaccctg taacgtggaa atcttatcac acacctgtta tccaacaagt ctacctgagg     2160

ggttttgtta cactttaaat gggaaggcat agggatttat gaatggggct ttcaccttct     2220

catacccagg caaccaacac ctgattttgt ctcaactggc tagcaaatgc ccagccttca     2280

gagtgtgcag gaatgttttc aaatccctca tcagactgtg actttaacat taatttggaa     2340

tcctgtgagc actactctga aggtttgtgt tttggcaaat cttttttctt ttttgagaca     2400

gggctctgct aaatattgct caggctggtt gcaaactcct tgcttcaagg gatcctccca     2460

cctcagcctc ccaagcagcc gggactgcag gcacaagcca ccatgcctgg ctgttttttg     2520

gcaaatcttg attgtgataa gcccccctgg aggatatgat tcactttatg tgattcatct     2580

tattcacagg tctgtgaggg actgcaaagc ttactcagga aatgaaaaca aatgatggtc     2640

atgttgcagt tttttccttg aaggacaacc gaaccatagc ctctaaagtt caagtgcact     2700

gaggtgtcgg aacgctgaaa gcatgaggaa acgaggacgt agggtgtgac tgaatggtgg     2760

ctagattagt gggagcagtt cacctggatg aagattgaga gcatcgtctt tgagaagtga     2820

aagactagca agaataaaat aaattaagtc cagtgtttga gccaaggttg ccacctgtct     2880

cttaacatct cactgaacat aagtcctgag gtattaggac gaccatactg cctctgagct     2940

gaaaacattc aaaagttcac atccctgttt gggggatacc attcaccgcc ttcagcccag     3000

atgatacttt cctttaaatc tgtgtctctg tgtgtataac aaagaggaag atggaaacaa     3060

tgttcatgga aactgctgtt gagccccttg tcccaccact cccgccatct gctgcaggca     3120

ggaaggcatg tgagtgtacg ttttcttcca ggagacatca ggtccccctg gattcaaatt     3180

aagtgcaata ttttgcaaac agctcttctt agggaaatct cctgaaggaa aaaaatgtga     3240

cagaatgttc catagtctga gagaatggaa tcgttgagca tttagtacaa gtccagtgtg     3300

tgtgagcggg acttaggcag ctcaagcttg cttttttttt taagcgtaca attgagtggt     3360

tttagtaaat tcacaaactt gttcaaccat caccactatc taattccaga ctcacgcttt     3420

tttaaacaat aaatgtcatt tcatgaaatc tttggtgata aagtattttg gattcagaga     3480

agagctccct taccagtccc accctgatct catggctgtc tctcctttca ttgtcagact     3540

ccccctggtc taccgcgttg atgtgtatac actgatcttt caagtctggg agacagataa     3600

ggaggccagg tgcaaggcag ggaggcagag agaatgttgt gcttccttta gcttttgtat     3660

ttcgatggcc agcattaccc tttacctgtg ggcatcagac tcagcgtggg ctgagtgctg     3720

agtgtaactt acactcctaa atcaagctgg ggcctgggtg ggcccctctt ggtatctgtg     3780

aatctttcca agcaccactt cggacacacc agggattgag tgctgctgtt agtttagaga     3840

aggagagatg tctaaccctt gaggtgaagg gctctgggag ggtccaagaa gacgtaggct     3900

tcattttcac accagcccac accattccag tgctcagcct agcaaatgtg ctttaatgca     3960

cacttctcag acctgtgatc cgtgtatctt ctccccagtg acagaagtag agaagagaat     4020

ggaaagcagc acactccgtc ccctctagtc tggagctgtt aacagaatct gctagaaact     4080

agctttattc taacataccg taggatctaa atcctcctac ctggatcatg aattcctttg     4140

aaataattca tattttcatt gactctcact aaatgtcaaa taaccttgtt ttcacttgga     4200

taggctcaac ctacctggca tatttatttt gcagtcttgt tgaaagttca tgaaactttg     4260

tactttttaa taagatgata cactcgaagg aaacttttaa tctctgcagt ttattctctc     4320

ttaaggaata aacactccca ctgtttgttc tcttcaatgt gtaaggagat taaatgacat     4380

tttagaaata ttacaattaa aaatagtgat gtagctgtaa catatgctgg aattggatat     4440

ttaatttatg tttgtgtcaa ctataatcct ttccccaccc ctttcattta tggtaaacat     4500

cttgggcaaa cccaaagatg gaaagtgctt gttgggtggg taagcaccac ctggtctctc     4560

agcaaacact cctgagtggt tgaagatgct ggacattgga ttctagcact gggtttatct     4620

ggtgacatag tctcctgtgg gtcttgagtt ggttatttca agctcaaact ctgaatatga     4680

ttaaaccaga acaccccacc cccaactgcc aaaaaaaaaa aaaaaaaatg gaaatccata     4740

atgaaacagc aaaaaagtac tccgttgctg ggtttggaca atgaacatgg gattagtccc     4800

aagtttgtag cttggaacgg tagcattttt gcctgcgtga tccttgtcag ctattcacag     4860

aaggaaatct tccgaaactc cgtctttcat ttcagccggt gaggctgtta tccttctctg     4920

tcaattagca ttcatgtggt tttcgctctt tccagctctg tcactcttgt tttcatttaa     4980

atattgcccc actctgtgtt tattgccttg ccatttctct agcatatcag gtttaattat     5040

gggctcagta ataatgagga actagcttcc ctcaggcaac taattacttt tgtctttttt     5100

ggtcggattg taccaaatta ttttgcattg aatgggaatg tttttgcagt gaatccagat     5160

atagttgtat tggtttggaa aaacatttaa atatatttat tcatatgaac atgtgtgatt     5220

aaacaaccta ttttacatat ttctgtaatt ctgaggagtg ggctgggggt aggaagaaat     5280

ggcaccactt aaaattcagg gcttatatga agaggtgttt taaggttagc acatgcacaa     5340

aggaacgagt tggtttaaaa agataaatca ctgcaaagaa tgaaattggc ttattcacat     5400

caaaactaga taagatgcta aaaaaaaaag atatgaaaca gaactaacct atagtttcct     5460

gaaatcagta cagtttaatt tataagaagc tagaaagtaa tgcaccttga ttgttttagg     5520

aatgatttat gtgttgcaat tttaatttat ttaaagcatg tctactgtgt ttgtcctaag     5580

agaaatattt caacaaaacg tgctctgtgt ttaagatatg tttaggcagt agttagcaac     5640

tctgaaagta gaaactggaa atgtttattg tgaggcttgt tgcagaattt ccattttgtg     5700

agttactact tagtttcatg tcagcctaaa attgtaaatt ccctgtagat cttcacccca     5760

ttgtggtgtc atcaatgaat ccaaagcagg tgccattatt tttttaaata aacacttgat     5820

gttagctttg gtgttaaata aagaggtaga tttcttaaat tttaaaa                   5867


<210>  4
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
ccggcgacaa cattgctcac ttgaactcga gttcaagtga gcaatgttgt cgttttttg        59


<210>  5
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
ccggcgtcat gacatgaata ccttactcga gtaaggtatt catgtcatga cgttttttg        59


<210>  6
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
ccgggatggg aatgttgcgg agtatctcga gatactccgc aacattccca tcttttttg        59


<210>  7
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Pro His Cys Met Glu Ser Ser Lys Ser Gly Met Pro Gly Val Ser Leu 
1               5                   10                  15      


Thr Pro Pro Val Phe Val Phe Asn Lys Ser Arg Glu Phe Ala Asn 
            20                  25                  30      


<210>  8
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Ser Arg Glu Phe Ala Asn Leu Ile Arg Asn Lys Phe Gly Ser Ala Asp 
1               5                   10                  15      


Asn Ile Ala His Leu Lys Asn Ser Leu Glu Glu Phe Arg Pro Glu 
            20                  25                  30      


<210>  9
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Glu Glu Phe Arg Pro Glu Ala Ser Ala Arg Ala Tyr Gly Gly Ser Ala 
1               5                   10                  15      


Thr Ile Val Asn Lys Pro Lys Tyr Gly Ser Asp Asp Glu Cys Ser 
            20                  25                  30      


<210>  10
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Ser Asp Asp Glu Cys Ser Ser Gly Thr Ser Gly Ser Ala Asp Ser Asn 
1               5                   10                  15      


Gly Asn Gln Ser Phe Gly Ala Gly Gly Ala Ser Thr Leu 
            20                  25                  


<210>  11
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Asp Ile Ser Lys Asp His Leu Lys Asp Ile His Arg Ser Leu Lys Asp 
1               5                   10                  15      


Ala His Val Lys Ser Arg Thr Ala Pro His Cys Met Glu Ser Ser Lys 
            20                  25                  30          


Ser Gly Met Pro Gly Val Ser Leu Thr Pro Pro Val Phe Val Phe Asn 
        35                  40                  45              


Lys Ser Arg Glu Phe Ala Asn Leu Ile Arg Asn Lys Phe Gly Ser Ala 
    50                  55                  60                  


Asp Asn Ile 
65          


<210>  12
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gly Ser Ala Asn Ile Ala His Leu Lys Asn Ser Leu Glu Glu Phe Arg 
1               5                   10                  15      


Pro Glu Ala Ser Ala Arg Ala Tyr Gly Gly Ser Ala Thr Ile Val Asn 
            20                  25                  30          


Lys Pro Lys Arg Gly Ser Asp Asp Glu Cys Ser Ser Gly Thr Ser Gly 
        35                  40                  45              


Ser Ala Asp Ser Asn Gly Asn Gln Ser Phe Gly Ala Gly Gly Ala Ser 
    50                  55                  60                  


Thr Leu 
65      


<210>  13
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  13

Gly Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   10  


<210>  14
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  14

Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe Asp 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  15

Asn Phe Asp Tyr 
1               


<210>  16
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  16

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  17
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  17

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  18

Gln Gln Tyr Ser Gly Tyr Pro Leu Thr 
1               5                   


<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Asp Ile Ser Lys Asp His Leu Lys Asp Ile His Arg Ser Leu Lys Asp 
1               5                   10                  15      


Ala His Val Lys Ser Arg Thr Ala Pro His Cys Met Glu Ser 
            20                  25                  30  


