                         SEQUENCE LISTING

<110>  Asklepios Biopharmaceutical, Inc.
       Samulski, Richard J.
       Grieger, Joshua C.
 
<120>  OPTIMIZED AND MODIFIED FACTOR VIII GENES FOR GENE THERAPY

<130>  014860.026PCT

<150>  61/971,616
<151>  2014-03-28

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  4416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
atgcagattg aactgtccac ttgtttcttt ctgtgcctgc tgaggttttg tttttccgca       60

actaggcggt actatctggg agccgtcgaa ctgtcatggg attacatgca gagcgacctg      120

ggagagctgc cagtggacgc acgatttcca cctagagtcc ctaaatcctt ccccttcaac      180

acctctgtgg tctataagaa aacactgttc gtggagttca ccgatcacct gttcaacatc      240

gcaaagccta ggccaccctg gatgggactg ctgggaccaa caatccaggc cgaggtgtac      300

gacaccgtgg tcattacact gaaaaatatg gcctcacacc cagtgagcct gcatgctgtg      360

ggcgtctctt actggaaggc tagtgaaggg gcagagtatg acgatcagac aagccagcgc      420

gaaaaagagg acgataaggt gtttcccggc gggtcccata cttacgtgtg gcaggtcctg      480

aaagagaatg gccccatggc ttccgaccct ctgtgcctga cctactctta tctgagtcac      540

gtggacctgg tcaaggatct gaactccggc ctgatcgggg ccctgctggt gtgccgggag      600

ggatctctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg      660

tttgacgaag gaaaatcatg gcacagcgag accaagaata gcctgatgca ggacagggat      720

gcagcttccg cccgagcttg gccaaaaatg cacacagtga acggctacgt caatcggtcc      780

ctgccaggac tgatcggatg ccacagaaag agcgtgtact ggcatgtcat cggaatgggc      840

accacacccg aagtgcactc cattttcctg gaggggcata cctttctggt ccgcaaccac      900

cgacaggctt ccctggagat ctctcctatt accttcctga cagcacagac tctgctgatg      960

gatctgggac agttcctgct gttttgccac atcagctccc accagcatga tggcatggag     1020

gcttacgtga aagtggacag ctgtcccgag gaacctcagc tgcggatgaa gaacaatgag     1080

gaagcagaag actatgacga tgacctgact gactccgaga tggatgtggt caggttcgat     1140

gacgataaca gcccatcctt tatccagatt cgctctgtgg ccaagaaaca ccccaagaca     1200

tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggcc     1260

cccgacgata gatcctacaa atctcagtat ctgaacaatg gacctcagcg gattggcaga     1320

aagtacaaga aagtgcgatt catggcatat accgatgaga ccttcaagac tagagaagcc     1380

atccagcacg agagcgggat tctgggacca ctgctgtacg gcgaagtggg ggacactctg     1440

ctgatcatct tcaagaacca ggcctctcgg ccttacaata tctatccaca tggaattacc     1500

gatgtgagac ctctgtacag ccggagactg ccaaagggcg tcaaacacct gaaggacttc     1560

ccaatcctgc ccggggaaat cttcaagtac aaatggactg tcaccgtcga ggatggcccc     1620

actaagagcg accctaggtg cctgacccgc tactattcta gtttcgtgaa tatggaaagg     1680

gatctggcct ccggactgat cggcccactg ctgatttgtt acaaagagtc tgtggatcag     1740

cgcggcaacc agatcatgag tgacaagcga aatgtgattc tgttcagcgt ctttgacgaa     1800

aacaggtcct ggtatctgac cgagaacatc cagcggttcc tgcctaatcc agctggagtg     1860

cagctggaag atcctgagtt tcaggcatca aacatcatgc atagcattaa tggctacgtg     1920

ttcgacagtc tgcagctgag cgtgtgcctg cacgaggtcg cttactggta tatcctgtcc     1980

attggagcac agaccgattt cctgagcgtg ttcttttccg gctacacctt caagcacaaa     2040

atggtgtatg aggacacact gactctgttc cctttttctg gcgaaaccgt gtttatgagt     2100

atggagaatc cagggctgtg gatcctggga tgccacaact ctgatttcag gaatcgcggg     2160

atgacagctc tgctgaaagt gtcaagctgt gacaagaaca ctggagacta ctatgaagat     2220

tcctacgagg acatctctgc atatctgctg agtaagaaca atgccattga acccaggtct     2280

tttagtcaga attctagaca tcctagtaca aggcagaaac agttcaacgc cactcctcca     2340

gtgctgaaga ggcaccagcg cgagatcact cgcactaccc tgcagagtga tcaggaagag     2400

atcgactacg acgataccat tagcgtggaa atgaagaaag aggacttcga tatctatgac     2460

gaagatgaga accagagtcc cagatcattc cagaagaaaa ccaggcatta ctttattgct     2520

gcagtggagc gcctgtggga ttatggcatg tcctctagtc cccacgtgct gcgaaatcgg     2580

gcccagtcag ggagcgtccc tcagttcaag aaagtggtct tccaggagtt tacagacgga     2640

tcttttactc agcctctgta caggggcgaa ctgaacgagc acctggggct gctgggacca     2700

tatatccgcg cagaagtgga ggataacatt atggtcacct tccgcaatca ggcctcacga     2760

ccctacagct tttattcaag cctgatcagc tacgaagagg accagcgaca gggagctgaa     2820

ccacgaaaaa acttcgtgaa gcctaatgag accaaaacat acttttggaa ggtgcagcac     2880

catatggccc ctacaaaaga cgaattcgat tgcaaggcat gggcctattt ttcagacgtg     2940

gatctggaga aggacgtgca cagcggactg atcggacctc tgctggtgtg ccatactaac     3000

accctgaatc cagcacacgg ccggcaggtg acagtccagg aattcgctct gttctttacc     3060

atctttgatg agacaaaatc ctggtacttc actgaaaaca tggagcgaaa ttgccgggcc     3120

ccatgtaata ttcagatgga agaccccacc ttcaaggaga actacagatt tcatgctatc     3180

aatgggtata ttatggatac actgcccgga ctggtcatgg cacaggacca gagaatcagg     3240

tggtacctgc tgagcatggg gtccaacgag aatatccact ccattcattt ctctggacac     3300

gtgtttacag tccggaagaa agaagagtat aaaatggccc tgtacaacct gtatccaggc     3360

gtgttcgaaa ctgtcgagat gctgcccagc aaggccggga tctggagagt ggaatgcctg     3420

attggggagc acctgcatgc tggaatgtca actctgtttc tggtgtacag caataagtgt     3480

cagaccccac tggggatggc aagtggacat atccgggatt tccagattac cgcatcagga     3540

cagtacggac agtgggcacc caagctggct agactgcact attccgggtc tatcaacgcc     3600

tggagtacca aagagccctt ctcatggatt aaggtggacc tgctggcccc tatgatcatt     3660

catggcatca aaacacaggg ggctaggcag aagttctcct ctctgtacat ctcccagttt     3720

atcatcatgt actctctgga tggcaagaaa tggcagacct accgcggcaa tagcacaggg     3780

actctgatgg tgttctttgg caacgtggac agttcaggga tcaagcacaa cattttcaat     3840

ccccctatca ttgccagata catcaggctg caccctaccc attattctat tcgaagtaca     3900

ctgcggatgg aactgatggg gtgcgatctg aacagttgtt caatgccact gggaatggag     3960

agtaaggcaa tctcagacgc ccagattacc gctagctcct acttcactaa tatgtttgct     4020

acctggagcc cctccaaagc aagactgcac ctgcagggcc ggtccaacgc atggagacca     4080

caggtgaaca atcccaagga gtggctgcag gtcgattttc agaaaactat gaaggtgacc     4140

ggagtcacaa ctcagggcgt gaaaagcctg ctgacttcca tgtacgtcaa ggagttcctg     4200

atctctagtt cacaggacgg ccatcagtgg accctgttct ttcagaacgg aaaggtgaaa     4260

gtcttccagg gcaatcagga tagttttacc cccgtggtca actcactgga cccacccctg     4320

ctgacacgct atctgcgaat ccaccctcag agctgggtgc atcagattgc cctgcggatg     4380

gaagtgctgg ggtgtgaagc ccaggacctg tattga                               4416


<210>  2
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2
atgcagattg aactgtccac ttgtttcttt ctgtgtctgc tgaggttttg tttttccgct       60

actaggaggt actatctggg agccgtggaa ctgtcttggg attacatgca gagtgacctg      120

ggagagctgc cagtggacgc acgatttcca cctagagtcc ctaaatcatt ccccttcaac      180

accagcgtgg tctataagaa aacactgttc gtggagttta ctgatcacct gttcaacatc      240

gctaagcctc ggccaccctg gatgggactg ctgggaccaa caatccaggc agaggtgtac      300

gacaccgtgg tcattacact gaaaaacatg gcctcacacc ccgtgagcct gcatgctgtg      360

ggcgtcagct actggaaggc ttccgaaggg gcagagtatg acgatcagac ttcccagaga      420

gaaaaagagg acgataaggt gtttcctggc gggtctcata cctatgtgtg gcaggtcctg      480

aaagagaatg gccccatggc ttccgaccct ctgtgcctga cctactctta tctgagtcac      540

gtggacctgg tcaaggatct gaacagcgga ctgatcggag cactgctggt gtgtagggaa      600

gggagcctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg      660

tttgacgaag gaaaatcatg gcacagcgag acaaagaata gtctgatgca ggaccgggat      720

gccgcttcag ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca      780

ctgcctggac tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cggaatgggc      840

accacacctg aagtgcactc cattttcctg gaggggcata cctttctggt ccgcaaccac      900

cgacaggcct ccctggagat ctctccaatt accttcctga cagctcagac tctgctgatg      960

gatctgggac agttcctgct gttttgccac atcagctccc accagcatga tggcatggag     1020

gcctacgtga aagtggacag ctgtcccgag gaacctcagc tgaggatgaa gaacaatgag     1080

gaagctgaag actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat     1140

gacgataaca gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca     1200

tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca     1260

ccagacgatc gatcctacaa atctcagtat ctgaacaatg gaccacagcg gattggcaga     1320

aagtacaaga aagtgaggtt catggcttat accgatgaaa ccttcaagac ccgggaggca     1380

atccagcacg agagcgggat tctgggacca ctgctgtacg gagaagtggg ggacaccctg     1440

ctgatcattt ttaagaacca ggccagcagg ccttacaata tctatccaca tggaattaca     1500

gatgtgcgcc ctctgtacag ccggagactg ccaaagggcg tcaaacacct gaaggacttc     1560

ccaatcctgc ccggggaaat ttttaagtat aaatggactg tcaccgtcga ggatggcccc     1620

actaagagcg accctaggtg cctgacccgc tactattcta gtttcgtgaa tatggaaagg     1680

gatctggcca gcggactgat cggcccactg ctgatttgtt acaaagagag cgtggatcag     1740

agaggcaacc agatcatgtc cgacaagagg aatgtgattc tgttcagtgt ctttgacgaa     1800

aaccggtcat ggtatctgac cgagaacatc cagagattcc tgcctaatcc agccggagtg     1860

cagctggaag atcctgagtt tcaggcttct aacatcatgc atagtattaa tggctacgtg     1920

ttcgacagtc tgcagctgtc agtgtgtctg cacgaggtcg cttactggta tatcctgagc     1980

attggagcac agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa     2040

atggtgtatg aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgtcc     2100

atggagaatc ccgggctgtg gatcctggga tgccacaaca gcgatttcag gaatcgcggg     2160

atgactgccc tgctgaaagt gtcaagctgt gacaagaaca ccggagacta ctatgaagat     2220

tcatacgagg acatcagcgc atatctgctg tccaaaaaca atgccattga acccaggtct     2280

tttagtcaga atcctccagt gctgaagagg caccagcgcg agatcacccg cactaccctg     2340

cagagtgatc aggaagagat cgactacgac gatacaattt ctgtggaaat gaagaaagag     2400

gacttcgata tctatgacga agatgagaac cagagtcctc gatcattcca gaagaaaacc     2460

cggcattact ttattgctgc agtggagcgc ctgtgggatt atggcatgtc ctctagtcct     2520

cacgtgctgc gaaatcgggc ccagtcaggg agcgtcccac agttcaagaa agtggtcttc     2580

caggagttta cagacggatc ctttactcag ccactgtacc ggggcgaact gaacgagcac     2640

ctggggctgc tgggacccta tatcagagct gaagtggagg ataacattat ggtcaccttc     2700

agaaatcagg catctaggcc ttacagtttt tattcaagcc tgatctctta cgaagaggac     2760

cagaggcagg gagcagaacc acgaaaaaac ttcgtgaagc ctaatgagac caaaacatac     2820

ttttggaagg tgcagcacca tatggcccca acaaaagacg aattcgattg caaggcatgg     2880

gcctattttt ctgacgtgga tctggagaag gacgtccaca gtggcctgat cgggccactg     2940

ctggtgtgtc atactaacac cctgaatccc gcacacggca ggcaggtcac tgtccaggaa     3000

ttcgccctgt tctttaccat ctttgatgag acaaaaagct ggtacttcac cgaaaacatg     3060

gagcgaaatt gccgggctcc atgtaatatt cagatggaag accccacatt caaggagaac     3120

taccgctttc atgccatcaa tgggtatatt atggatactc tgcccggact ggtcatggct     3180

caggaccaga gaatcaggtg gtacctgctg agcatggggt ccaacgagaa tatccactca     3240

attcatttca gcggacacgt gtttactgtc cggaagaaag aagagtataa aatggccctg     3300

tacaacctgt atcccggcgt gttcgaaacc gtcgagatgc tgcctagcaa ggcagggatc     3360

tggagagtgg aatgcctgat tggggagcac ctgcatgccg gaatgtctac cctgtttctg     3420

gtgtacagta ataagtgtca gacacccctg gggatggctt ccggacatat ccgggatttc     3480

cagattaccg catctggaca gtacggccag tgggccccta agctggctag actgcactat     3540

tccgggtcta tcaacgcttg gtccacaaaa gagcctttct cttggattaa ggtggacctg     3600

ctggcaccaa tgatcattca tggcatcaaa actcaggggg ccaggcagaa gttctcctct     3660

ctgtacatct cacagtttat catcatgtac agcctggatg gcaagaaatg gcagacatac     3720

cgcggcaata gcacagggac tctgatggtg ttctttggca acgtggacag ttcagggatc     3780

aagcacaaca ttttcaatcc ccctatcatt gctagataca tcaggctgca cccaacccat     3840

tattctattc gaagtacact gcggatggaa ctgatggggt gcgatctgaa cagttgttca     3900

atgcccctgg gaatggagtc caaggcaatc tctgacgccc agattaccgc tagctcctac     3960

ttcactaata tgtttgctac ctggagcccc tccaaagcac ggctgcatct gcagggacga     4020

agcaacgcat ggcgaccaca ggtgaacaat cccaaggagt ggctgcaggt cgattttcag     4080

aaaactatga aggtgaccgg agtcacaact cagggcgtga aaagtctgct gacctcaatg     4140

tacgtcaagg agttcctgat ctctagttca caggacggcc accagtggac actgttcttt     4200

cagaacggaa aggtgaaagt cttccagggc aatcaggatt cctttacacc tgtggtcaac     4260

tctctggacc cacccctgct gactcgctac ctgcgaatcc acccacagtc ctgggtgcat     4320

cagattgcac tgagaatgga agtcctgggc tgcgaggccc aggacctgta ttga           4374


<210>  3
<211>  4416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3
atgcagatcg agctgtccac atgctttttt ctgtgcctgc tgcggttctg cttcagcgcc       60

acccggcggt actacctggg cgccgtggag ctgtcctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggacgc ccggttcccc cccagagtgc ccaagagctt ccccttcaac      180

accagcgtgg tgtacaagaa aaccctgttc gtggagttca ccgaccacct gttcaacatc      240

gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc cgaggtgtac      300

gacaccgtgg tgatcaccct gaagaacatg gccagccacc ccgtgagcct gcacgccgtg      360

ggcgtgagct actggaaggc ctccgagggc gccgagtacg acgaccagac cagccagcgg      420

gagaaagagg acgacaaagt ctttcctggc ggcagccaca cctacgtgtg gcaggtcctg      480

aaagaaaacg gccccatggc ctccgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tgaaggacct gaacagcggg ctgattgggg ccctgctggt ctgccgggag      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag accaagaaca gcctgatgca ggaccgggac      720

gccgcctctg ccagagcctg gcccaagatg cacaccgtga acggctacgt gaacagaagc      780

ctgcccggcc tgattggctg ccaccggaag agcgtgtact ggcacgtgat cggcatgggc      840

accacacccg aggtgcacag catctttctg gaagggcaca cctttctggt gcggaaccac      900

cggcaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agttcctgct gttttgccac atcagctctc accagcacga cggcatggaa     1020

gcctacgtga aggtggactc ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gcggttcgac     1140

gacgacaaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact acatcgccgc cgaggaagag gactgggact acgcccccct ggtgctggcc     1260

cccgacgaca gaagctacaa gagccagtac ctgaacaatg gcccccagcg gatcggccgg     1320

aagtacaaga aagtgcggtt catggcctac accgacgaga ccttcaagac ccgggaggcc     1380

atccagcacg agagcggcat cctgggcccc ctgctgtacg gcgaagtggg cgacacactg     1440

ctgatcatct tcaagaacca ggccagccgg ccctacaaca tctaccccca cggcatcacc     1500

gacgtgcggc ccctgtacag caggcggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga ggacggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gcttcgtgaa catggaacgg     1680

gacctggcct ccgggctgat cggacctctg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgttcagcgt gttcgatgag     1800

aaccggtcct ggtatctgac cgagaacatc cagcggtttc tgcccaaccc tgccggggtg     1860

cagctggaag atcccgagtt ccaggccagc aacatcatgc actccatcaa tggctacgtg     1920

ttcgacagcc tgcagctgtc cgtgtgtctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggacaccct gaccctgttc cctttcagcg gcgagaccgt gttcatgagc     2100

atggaaaacc ccggcctgtg gatcctgggc tgccacaaca gcgacttccg gaaccggggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctacgagg atatcagcgc ctacctgctg tccaagaaca acgccatcga gcccagaagc     2280

ttcagccaga acagccggca ccccagcacc cggcagaagc agttcaacgc caccccccct     2340

gtgctgaagc ggcaccagag agagatcacc cggaccaccc tgcagtccga ccaggaagag     2400

atcgattacg acgacaccat cagcgtggag atgaaaaaag aagatttcga catctacgac     2460

gaggacgaga accagagccc ccggtccttc cagaagaaaa cccggcacta ctttatcgcc     2520

gccgtggagc ggctgtggga ctacggcatg agcagcagcc cccacgtgct gcggaaccgg     2580

gcccagagcg gcagcgtgcc ccagttcaag aaagtggtgt tccaggaatt caccgacggc     2640

agcttcaccc agcccctgta ccggggcgag ctgaacgagc acctggggct gctggggccc     2700

tacatcaggg ccgaagtgga ggacaacatc atggtgacct tccggaatca ggccagcaga     2760

ccctactcct tctacagcag cctgatcagc tacgaagagg accagcggca gggcgctgaa     2820

ccccggaaga acttcgtgaa gcccaatgag accaagacct acttctggaa agtgcagcac     2880

cacatggccc ccaccaagga cgagttcgac tgcaaggcct gggcctactt cagcgacgtg     2940

gatctggaaa aggacgtgca ctctggactg attggccctc tgctggtgtg ccacaccaac     3000

accctgaacc ccgcccacgg ccggcaggtg accgtgcagg aattcgccct gttcttcacc     3060

atcttcgacg agaccaagtc ctggtacttc accgagaata tggaacggaa ctgcagagcc     3120

ccctgcaaca tccagatgga agatcctacc ttcaaagaga actaccggtt ccacgccatc     3180

aacggctaca tcatggacac cctgcctggc ctggtgatgg cccaggacca gaggatccgg     3240

tggtatctgc tgtccatggg cagcaacgag aatatccaca gcatccactt cagcggccac     3300

gtgttcaccg tgaggaagaa agaagagtac aagatggccc tgtacaacct gtaccccggc     3360

gtgttcgaga ccgtggagat gctgcccagc aaggccggca tctggcgggt ggagtgtctg     3420

atcggcgagc acctgcatgc cgggatgagc accctgtttc tggtgtacag caacaagtgc     3480

cagacccccc tgggcatggc cagcggccac atccgggact tccagatcac cgcctccggc     3540

cagtacggcc agtgggcccc caagctggcc cggctgcact acagcggcag catcaacgcc     3600

tggtccacca aagagccctt cagctggatc aaggtggacc tgctggcccc tatgatcatc     3660

cacggcatta agacccaggg cgccaggcag aagttcagca gcctgtacat cagccagttc     3720

atcatcatgt acagcctgga cggcaagaag tggcagacct accggggcaa cagcaccggc     3780

accctgatgg tgttcttcgg caacgtggac agcagcggca tcaagcacaa catcttcaac     3840

ccccccatca tcgcccggta catccggctg caccccaccc actacagcat cagatccacc     3900

ctgcggatgg aactgatggg ctgcgacctg aactcctgca gcatgcctct gggcatggaa     3960

agcaaggcca tcagcgacgc ccagatcaca gccagcagct acttcaccaa catgttcgcc     4020

acctggtccc cctccaaggc caggctgcac ctgcagggcc ggtccaacgc ctggcggcct     4080

caggtgaaca accccaaaga atggctgcag gtggactttc agaaaaccat gaaggtgacc     4140

ggcgtgacca cccagggcgt gaaaagcctg ctgaccagca tgtacgtgaa agagtttctg     4200

atcagcagca gccaggacgg ccaccagtgg accctgttct ttcagaacgg caaggtgaaa     4260

gtgttccagg gcaaccagga ctccttcacc cccgtggtga actccctgga cccccccctg     4320

ctgacccgct acctgcggat ccacccccag tcttgggtgc accagatcgc cctgaggatg     4380

gaagtgctgg gatgtgaggc ccaggatctg tactga                               4416


<210>  4
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4
atgcagatcg agctgtccac atgctttttt ctgtgcctgc tgcggttctg cttcagcgcc       60

acccggcggt actacctggg cgccgtggag ctgtcctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggacgc ccggttcccc cccagagtgc ccaagagctt ccccttcaac      180

accagcgtgg tgtacaagaa aaccctgttc gtggagttca ccgaccacct gttcaacatc      240

gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc cgaggtgtac      300

gacaccgtgg tgatcaccct gaagaacatg gccagccacc ccgtgagcct gcacgccgtg      360

ggcgtgagct actggaaggc ctccgagggc gccgagtacg acgaccagac cagccagcgg      420

gagaaagagg acgacaaagt ctttcctggc ggcagccaca cctacgtgtg gcaggtcctg      480

aaagaaaacg gccccatggc ctccgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tgaaggacct gaacagcggg ctgattgggg ccctgctggt ctgccgggag      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag accaagaaca gcctgatgca ggaccgggac      720

gccgcctctg ccagagcctg gcccaagatg cacaccgtga acggctacgt gaacagaagc      780

ctgcccggcc tgattggctg ccaccggaag agcgtgtact ggcacgtgat cggcatgggc      840

accacacccg aggtgcacag catctttctg gaagggcaca cctttctggt gcggaaccac      900

cggcaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agttcctgct gttttgccac atcagctctc accagcacga cggcatggaa     1020

gcctacgtga aggtggactc ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gcggttcgac     1140

gacgacaaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact acatcgccgc cgaggaagag gactgggact acgcccccct ggtgctggcc     1260

cccgacgaca gaagctacaa gagccagtac ctgaacaatg gcccccagcg gatcggccgg     1320

aagtacaaga aagtgcggtt catggcctac accgacgaga ccttcaagac ccgggaggcc     1380

atccagcacg agagcggcat cctgggcccc ctgctgtacg gcgaagtggg cgacacactg     1440

ctgatcatct tcaagaacca ggccagccgg ccctacaaca tctaccccca cggcatcacc     1500

gacgtgcggc ccctgtacag caggcggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga ggacggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gcttcgtgaa catggaacgg     1680

gacctggcct ccgggctgat cggacctctg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgttcagcgt gttcgatgag     1800

aaccggtcct ggtatctgac cgagaacatc cagcggtttc tgcccaaccc tgccggggtg     1860

cagctggaag atcccgagtt ccaggccagc aacatcatgc actccatcaa tggctacgtg     1920

ttcgacagcc tgcagctgtc cgtgtgtctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggacaccct gaccctgttc cctttcagcg gcgagaccgt gttcatgagc     2100

atggaaaacc ccggcctgtg gatcctgggc tgccacaaca gcgacttccg gaaccggggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctacgagg atatcagcgc ctacctgctg tccaagaaca acgccatcga gcccagaagc     2280

ttcagccaga acccccctgt gctgaagcgg caccagagag agatcacccg gaccaccctg     2340

cagtccgacc aggaagagat cgattacgac gacaccatca gcgtggagat gaaaaaagaa     2400

gatttcgaca tctacgacga ggacgagaac cagagccccc ggtccttcca gaagaaaacc     2460

cggcactact ttatcgccgc cgtggagcgg ctgtgggact acggcatgag cagcagcccc     2520

cacgtgctgc ggaaccgggc ccagagcggc agcgtgcccc agttcaagaa agtggtgttc     2580

caggaattca ccgacggcag cttcacccag cccctgtacc ggggcgagct gaacgagcac     2640

ctggggctgc tggggcccta catcagggcc gaagtggagg acaacatcat ggtgaccttc     2700

cggaatcagg ccagcagacc ctactccttc tacagcagcc tgatcagcta cgaagaggac     2760

cagcggcagg gcgctgaacc ccggaagaac ttcgtgaagc ccaatgagac caagacctac     2820

ttctggaaag tgcagcacca catggccccc accaaggacg agttcgactg caaggcctgg     2880

gcctacttca gcgacgtgga tctggaaaag gacgtgcact ctggactgat tggccctctg     2940

ctggtgtgcc acaccaacac cctgaacccc gcccacggcc ggcaggtgac cgtgcaggaa     3000

ttcgccctgt tcttcaccat cttcgacgag accaagtcct ggtacttcac cgagaatatg     3060

gaacggaact gcagagcccc ctgcaacatc cagatggaag atcctacctt caaagagaac     3120

taccggttcc acgccatcaa cggctacatc atggacaccc tgcctggcct ggtgatggcc     3180

caggaccaga ggatccggtg gtatctgctg tccatgggca gcaacgagaa tatccacagc     3240

atccacttca gcggccacgt gttcaccgtg aggaagaaag aagagtacaa gatggccctg     3300

tacaacctgt accccggcgt gttcgagacc gtggagatgc tgcccagcaa ggccggcatc     3360

tggcgggtgg agtgtctgat cggcgagcac ctgcatgccg ggatgagcac cctgtttctg     3420

gtgtacagca acaagtgcca gacccccctg ggcatggcca gcggccacat ccgggacttc     3480

cagatcaccg cctccggcca gtacggccag tgggccccca agctggcccg gctgcactac     3540

agcggcagca tcaacgcctg gtccaccaaa gagcccttca gctggatcaa ggtggacctg     3600

ctggccccta tgatcatcca cggcattaag acccagggcg ccaggcagaa gttcagcagc     3660

ctgtacatca gccagttcat catcatgtac agcctggacg gcaagaagtg gcagacctac     3720

cggggcaaca gcaccggcac cctgatggtg ttcttcggca acgtggacag cagcggcatc     3780

aagcacaaca tcttcaaccc ccccatcatc gcccggtaca tccggctgca ccccacccac     3840

tacagcatca gatccaccct gcggatggaa ctgatgggct gcgacctgaa ctcctgcagc     3900

atgcctctgg gcatggaaag caaggccatc agcgacgccc agatcacagc cagcagctac     3960

ttcaccaaca tgttcgccac ctggtccccc tccaaggcca ggctgcacct gcagggccgg     4020

tccaacgcct ggcggcctca ggtgaacaac cccaaagaat ggctgcaggt ggactttcag     4080

aaaaccatga aggtgaccgg cgtgaccacc cagggcgtga aaagcctgct gaccagcatg     4140

tacgtgaaag agtttctgat cagcagcagc caggacggcc accagtggac cctgttcttt     4200

cagaacggca aggtgaaagt gttccagggc aaccaggact ccttcacccc cgtggtgaac     4260

tccctggacc cccccctgct gacccgctac ctgcggatcc acccccagtc ttgggtgcac     4320

cagatcgccc tgaggatgga agtgctggga tgtgaggccc aggatctgta ctga           4374


<210>  5
<211>  4416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5
atgcagatcg agctttcgac ttgcttcttt ctgtgcctgc tccgcttctg cttttcagcg       60

actagacgct actacctcgg cgctgtcgag ctgagctggg actacatgca aagcgacctc      120

ggcgaactcc cggtcgacgc tagattcccg ccacgggtgc cgaagtcatt cccgttcaac      180

acttccgtgg tgtacaaaaa gaccctcttc gtcgagttca cggaccatct gttcaatatt      240

gccaagccta ggccaccgtg gatggggctg ctgggcccta ccattcaagc ggaagtctac      300

gatacggtgg tgatcactct gaaaaacatg gccagccacc cggtgtccct gcatgccgtg      360

ggcgtgtcct actggaaggc gtcagaagga gccgagtacg atgaccagac tagccagaga      420

gagaaggagg acgataaagt gttcccggga ggctcccaca cttacgtctg gcaggtgctg      480

aaggagaatg gaccgatggc ctcggaccca ctgtgcctga cctactcgta cttgagccac      540

gtcgacctgg tcaaggacct taactccggt ctgatcggag cgctgttggt gtgtagggaa      600

ggctcgctgg cgaaggaaaa gacccagacc ctgcataagt tcatcctcct cttcgccgtg      660

ttcgatgagg gcaaatcatg gcattccgaa actaaaaact cgctgatgca agaccgcgac      720

gctgcctcag cacgggcctg gccgaagatg cacactgtga acggttacgt caatcgctcg      780

ctcccgggac tgatcggttg tcaccgcaag tccgtgtact ggcatgtgat cggaatgggc      840

actactcccg aagtgcactc catttttctt gagggacaca cctttctcgt ccggaaccat      900

cgccaagcct cactcgaaat ctccccgatt acctttttga ccgctcaaac tctcctgatg      960

gacctcggac agtttctgct gttctgccac atctcctcac atcaacacga tggaatggaa     1020

gcgtacgtga aagtggattc ctgtccggag gaaccacagc tgcggatgaa gaacaatgag     1080

gaagccgaag attatgacga cgacctgacc gactccgaaa tggacgtcgt caggttcgac     1140

gatgataatt ccccgtcgtt tatccagatc cggtccgtgg ccaagaaaca tcctaaaact     1200

tgggtgcact acatcgcagc agaagaggaa gattgggact atgcaccgct cgtgttggcg     1260

ccagacgacc gctcgtacaa gtcacagtac ctcaataatg ggccccagag gatcggacgc     1320

aagtataaga aagtgcggtt catggcgtac actgatgaaa ctttcaagac ccgcgaggcc     1380

attcagcatg agtccggcat cttgggaccg ctcctctacg gcgaagtggg agacaccctg     1440

ctgatcatct tcaagaatca ggcttcccgg ccttacaaca tctaccctca cgggatcacc     1500

gatgtcaggc ctttgtactc cagacgcctc ccaaaagggg tgaaacatct caaggacttc     1560

ccgatcctgc caggcgaaat cttcaagtac aaatggacgg tgaccgtcga ggatggccca     1620

accaaatccg acccgcgctg tctgacccgc tactactcca gcttcgtgaa tatggaacgg     1680

gaccttgctt ccggcctgat cggacccttg ctgatctgct acaaggagtc ggtggatcag     1740

cggggtaacc agatcatgag cgacaaacgg aacgtcatcc tctttagcgt ctttgatgag     1800

aacagatcat ggtatcttac tgaaaacatc cagcggttcc tgcctaaccc agccggagtg     1860

cagcttgaag atcccgagtt ccaggcgagc aatatcatgc attcgattaa cggatacgtg     1920

ttcgactcac tccagctgtc agtgtgcctg cacgaagtgg cctactggta cattctgagc     1980

atcggagcac agactgattt cctgtcggtg ttctttagcg gttacacctt taaacataag     2040

atggtgtatg aggacaccct cactctgttc cctttttcgg gagagactgt gttcatgtcg     2100

atggagaacc ccggtctttg gatcttggga tgccacaact cagacttccg gaatcgcgga     2160

atgactgctc tgctgaaggt gtcaagctgt gataagaaca ctggcgacta ctacgaagat     2220

tcgtacgagg acatcagcgc ttatttgctc tcaaagaata acgccattga gccaagatcg     2280

ttctcccaaa actcgcggca cccgagcacc cgccaaaagc aattcaacgc caccccgcca     2340

gtgctgaaga gacatcaacg cgagattacc cgcaccactt tgcagtccga ccaggaggag     2400

atcgactacg acgacactat ctcagtcgag atgaaaaagg aggacttcga tatctacgac     2460

gaagatgaaa accagagccc gagatcattc cagaagaaaa cccgccacta ctttatcgca     2520

gcggtcgaac ggttgtggga ttacggaatg tcgtccagcc cgcatgtcct ccgcaacagg     2580

gcacagtccg ggagcgtgcc acagttcaag aaggtggtgt tccaagagtt caccgatggg     2640

tcctttactc agcccctgta cagaggagaa ctgaatgagc atctgggatt gctggggccg     2700

tacatcaggg ccgaagtgga ggataacatt atggtcacgt tccgcaatca ggcctcacgg     2760

ccctactcgt tctacagctc cctgatcagc tacgaagagg accagcgcca gggtgcggaa     2820

ccccggaaga acttcgtgaa gcctaacgaa accaagacct acttttggaa agtgcagcac     2880

cacatggcac caaccaaaga cgagtttgat tgcaaggcgt gggcatactt ctcggatgtg     2940

gatcttgaaa aggacgtgca ctcgggcctc atcggccctc tgctggtgtg ccacaccaat     3000

acgcttaacc cggctcatgg cagacaggtc actgtgcaag agttcgcgct gttcttcacc     3060

atcttcgacg aaacgaagtc atggtacttc accgaaaaca tggaaaggaa ttgcagagcg     3120

ccctgcaata tccagatgga agatccgacg tttaaggaaa actaccgctt ccacgccatc     3180

aacggataca tcatggacac tctgccagga ctggtcatgg cccaagacca aagaatccgg     3240

tggtacctcc tctcaatggg aagcaatgag aacatccatt cgatccactt tagcggacac     3300

gtgttcaccg tgaggaagaa agaagaatac aagatggccc tgtacaactt gtaccctggt     3360

gtgttcgaaa ccgtcgaaat gctgccctcc aaggccggaa tttggagagt ggaatgcctg     3420

attggtgaac atctccacgc cgggatgagc accctcttcc tcgtctactc gaacaagtgt     3480

caaactccgc ttggtatggc cagcgggcac atccgcgact tccaaatcac cgcgtcgggt     3540

cagtacggac agtgggcacc aaaacttgcg cggctgcact attccggatc aatcaacgcc     3600

tggtcgacta aagaaccgtt tagctggatt aaagtcgacc tcctggcacc tatgatcatc     3660

cacggcatta agactcaggg agcccggcag aagttctcat cgctgtacat ctcccagttc     3720

atcattatgt actcgctgga cggaaagaag tggcagacct accgcggaaa ctcaactgga     3780

accctgatgg tgttcttcgg gaatgtggac tcctcgggaa tcaagcataa catctttaac     3840

ccaccgatca ttgctcgcta tatccggctc cacccaacgc actactcgat cagatccact     3900

ctgcgcatgg aactgatggg gtgcgatctc aattcctgct cgatgccact gggaatggaa     3960

agcaaggcca tctcagacgc acagatcact gccagctcct acttcaccaa tatgttcgca     4020

acgtggtccc cgagcaaggc tagattgcac ctccaaggaa gatcgaacgc ttggcggcct     4080

caagtcaata accctaagga atggctgcaa gtcgattttc aaaagaccat gaaggtgacg     4140

ggcgtcacca cccaaggggt caaatcactt ctgacttcga tgtacgtgaa ggagttcctg     4200

atctcgtcgt cgcaagatgg acaccagtgg accctgtttt tccaaaacgg aaaggtgaag     4260

gtgtttcaag gcaatcagga ttcgttcacc ccggtggtca acagccttga cccgccattg     4320

ctgactcggt acctccgcat ccatccgcag agctgggtgc accagatcgc actgaggatg     4380

gaggtcctcg gatgcgaggc gcaagatctc tactga                               4416


<210>  6
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6
atgcagatcg agctttcgac ttgcttcttt ctgtgcctgc tccgcttctg cttttcagcg       60

actagacgct actacctcgg cgctgtcgag ctgagctggg actacatgca aagcgacctc      120

ggcgaactcc cggtcgacgc tagattcccg ccacgggtgc cgaagtcatt cccgttcaac      180

acttccgtgg tgtacaaaaa gaccctcttc gtcgagttca cggaccatct gttcaatatt      240

gccaagccta ggccaccgtg gatggggctg ctgggcccta ccattcaagc ggaagtctac      300

gatacggtgg tgatcactct gaaaaacatg gccagccacc cggtgtccct gcatgccgtg      360

ggcgtgtcct actggaaggc gtcagaagga gccgagtacg atgaccagac tagccagaga      420

gagaaggagg acgataaagt gttcccggga ggctcccaca cttacgtctg gcaggtgctg      480

aaggagaatg gaccgatggc ctcggaccca ctgtgcctga cctactcgta cttgagccac      540

gtcgacctgg tcaaggacct taactccggt ctgatcggag cgctgttggt gtgtagggaa      600

ggctcgctgg cgaaggaaaa gacccagacc ctgcataagt tcatcctcct cttcgccgtg      660

ttcgatgagg gcaaatcatg gcattccgaa actaaaaact cgctgatgca agaccgcgac      720

gctgcctcag cacgggcctg gccgaagatg cacactgtga acggttacgt caatcgctcg      780

ctcccgggac tgatcggttg tcaccgcaag tccgtgtact ggcatgtgat cggaatgggc      840

actactcccg aagtgcactc catttttctt gagggacaca cctttctcgt ccggaaccat      900

cgccaagcct cactcgaaat ctccccgatt acctttttga ccgctcaaac tctcctgatg      960

gacctcggac agtttctgct gttctgccac atctcctcac atcaacacga tggaatggaa     1020

gcgtacgtga aagtggattc ctgtccggag gaaccacagc tgcggatgaa gaacaatgag     1080

gaagccgaag attatgacga cgacctgacc gactccgaaa tggacgtcgt caggttcgac     1140

gatgataatt ccccgtcgtt tatccagatc cggtccgtgg ccaagaaaca tcctaaaact     1200

tgggtgcact acatcgcagc agaagaggaa gattgggact atgcaccgct cgtgttggcg     1260

ccagacgacc gctcgtacaa gtcacagtac ctcaataatg ggccccagag gatcggacgc     1320

aagtataaga aagtgcggtt catggcgtac actgatgaaa ctttcaagac ccgcgaggcc     1380

attcagcatg agtccggcat cttgggaccg ctcctctacg gcgaagtggg agacaccctg     1440

ctgatcatct tcaagaatca ggcttcccgg ccttacaaca tctaccctca cgggatcacc     1500

gatgtcaggc ctttgtactc cagacgcctc ccaaaagggg tgaaacatct caaggacttc     1560

ccgatcctgc caggcgaaat cttcaagtac aaatggacgg tgaccgtcga ggatggccca     1620

accaaatccg acccgcgctg tctgacccgc tactactcca gcttcgtgaa tatggaacgg     1680

gaccttgctt ccggcctgat cggacccttg ctgatctgct acaaggagtc ggtggatcag     1740

cggggtaacc agatcatgag cgacaaacgg aacgtcatcc tctttagcgt ctttgatgag     1800

aacagatcat ggtatcttac tgaaaacatc cagcggttcc tgcctaaccc agccggagtg     1860

cagcttgaag atcccgagtt ccaggcgagc aatatcatgc attcgattaa cggatacgtg     1920

ttcgactcac tccagctgtc agtgtgcctg cacgaagtgg cctactggta cattctgagc     1980

atcggagcac agactgattt cctgtcggtg ttctttagcg gttacacctt taaacataag     2040

atggtgtatg aggacaccct cactctgttc cctttttcgg gagagactgt gttcatgtcg     2100

atggagaacc ccggtctttg gatcttggga tgccacaact cagacttccg gaatcgcgga     2160

atgactgctc tgctgaaggt gtcaagctgt gataagaaca ctggcgacta ctacgaagat     2220

tcgtacgagg acatcagcgc ttatttgctc tcaaagaata acgccattga gccaagatcg     2280

ttctcccaaa acccgccagt gctgaagaga catcaacgcg agattacccg caccactttg     2340

cagtccgacc aggaggagat cgactacgac gacactatct cagtcgagat gaaaaaggag     2400

gacttcgata tctacgacga agatgaaaac cagagcccga gatcattcca gaagaaaacc     2460

cgccactact ttatcgcagc ggtcgaacgg ttgtgggatt acggaatgtc gtccagcccg     2520

catgtcctcc gcaacagggc acagtccggg agcgtgccac agttcaagaa ggtggtgttc     2580

caagagttca ccgatgggtc ctttactcag cccctgtaca gaggagaact gaatgagcat     2640

ctgggattgc tggggccgta catcagggcc gaagtggagg ataacattat ggtcacgttc     2700

cgcaatcagg cctcacggcc ctactcgttc tacagctccc tgatcagcta cgaagaggac     2760

cagcgccagg gtgcggaacc ccggaagaac ttcgtgaagc ctaacgaaac caagacctac     2820

ttttggaaag tgcagcacca catggcacca accaaagacg agtttgattg caaggcgtgg     2880

gcatacttct cggatgtgga tcttgaaaag gacgtgcact cgggcctcat cggccctctg     2940

ctggtgtgcc acaccaatac gcttaacccg gctcatggca gacaggtcac tgtgcaagag     3000

ttcgcgctgt tcttcaccat cttcgacgaa acgaagtcat ggtacttcac cgaaaacatg     3060

gaaaggaatt gcagagcgcc ctgcaatatc cagatggaag atccgacgtt taaggaaaac     3120

taccgcttcc acgccatcaa cggatacatc atggacactc tgccaggact ggtcatggcc     3180

caagaccaaa gaatccggtg gtacctcctc tcaatgggaa gcaatgagaa catccattcg     3240

atccacttta gcggacacgt gttcaccgtg aggaagaaag aagaatacaa gatggccctg     3300

tacaacttgt accctggtgt gttcgaaacc gtcgaaatgc tgccctccaa ggccggaatt     3360

tggagagtgg aatgcctgat tggtgaacat ctccacgccg ggatgagcac cctcttcctc     3420

gtctactcga acaagtgtca aactccgctt ggtatggcca gcgggcacat ccgcgacttc     3480

caaatcaccg cgtcgggtca gtacggacag tgggcaccaa aacttgcgcg gctgcactat     3540

tccggatcaa tcaacgcctg gtcgactaaa gaaccgttta gctggattaa agtcgacctc     3600

ctggcaccta tgatcatcca cggcattaag actcagggag cccggcagaa gttctcatcg     3660

ctgtacatct cccagttcat cattatgtac tcgctggacg gaaagaagtg gcagacctac     3720

cgcggaaact caactggaac cctgatggtg ttcttcggga atgtggactc ctcgggaatc     3780

aagcataaca tctttaaccc accgatcatt gctcgctata tccggctcca cccaacgcac     3840

tactcgatca gatccactct gcgcatggaa ctgatggggt gcgatctcaa ttcctgctcg     3900

atgccactgg gaatggaaag caaggccatc tcagacgcac agatcactgc cagctcctac     3960

ttcaccaata tgttcgcaac gtggtccccg agcaaggcta gattgcacct ccaaggaaga     4020

tcgaacgctt ggcggcctca agtcaataac cctaaggaat ggctgcaagt cgattttcaa     4080

aagaccatga aggtgacggg cgtcaccacc caaggggtca aatcacttct gacttcgatg     4140

tacgtgaagg agttcctgat ctcgtcgtcg caagatggac accagtggac cctgtttttc     4200

caaaacggaa aggtgaaggt gtttcaaggc aatcaggatt cgttcacccc ggtggtcaac     4260

agccttgacc cgccattgct gactcggtac ctccgcatcc atccgcagag ctgggtgcac     4320

cagatcgcac tgaggatgga ggtcctcgga tgcgaggcgc aagatctcta ctga           4374


<210>  7
<211>  373
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
tcgagcttgg gctgcaggtc gagggcactg ggaggatgtt gagtaagatg gaaaactact       60

gatgaccctt gcagagacag agtattagga catgtttgaa caggggccgg gcgatcagca      120

ggtagctcta gaggatcccc gtctgtctgc acatttcgta gagcgagtgt tccgatactc      180

taatctccct aggcaaggtt catatttgtg taggttactt attctccttt tgttgactaa      240

gtcaataatc agaatcagca ggtttggagt cagcttggca gggatcagca gcctgggttg      300

gaaggagggg gtataaaagc cccttcacca ggagaagccg tcacacagat ccacaagctc      360

ctgacaggaa gct                                                         373


<210>  8
<211>  349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
tcgagcttgg gctgcaggtc gagggcactg ggaggatgtt gagtaagatg gaaaactact       60

gatgaccctt gcagagacag agtattagga catgtttgaa caggggccgg gcgatcagca      120

ggtagctcta gaggatcccc gtctgtctgc acatttcgta gagcgagtgt tccgatactc      180

taatctccct aggcaaggtt catatttgtg taggttactt attctccttt tgttgactaa      240

gtcaataatc agaatcagca ggtttggagt cagcttggca gggatcagca gcctgggttg      300

gaaggagggg gtataaaagc cccttcacca ggagaagccg tcacacaga                  349


<210>  9
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
ctagccctaa ggtaagttgg cgccgtttaa gggatggttg gttggtgggg tattaatgtt       60

taattacctt ttttacaggc ctgaa                                             85


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
cccagcccac ttttccccaa                                                   20


<210>  11
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtg                   49


<210>  12
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  13
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagcgctt caacgggagc ctcgaacgac aatcactact ttggctacag caccccttgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca actggggatt ccgacccaag agactcaact tcaagctctt taacattcaa      960

gtcaaagagg tcacgcagaa tgacggtacg acgacgattg ccaataacct taccagcacg     1020

gttcaggtgt ttactgactc ggagtaccag ctcccgtacg tcctcggctc ggcgcatcaa     1080

ggatgcctcc cgccgttccc agcagacgtc ttcatggtgc cacagtatgg atacctcacc     1140

ctgaacaacg ggagtcaggc agtaggacgc tcttcatttt actgcctgga gtactttcct     1200

tctcagatgc tgcgtaccgg aaacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacttgag cagaacaaac actccaagtg gaaccaccac gcagtcaagg     1380

cttcagtttt ctcaggccgg agcgagtgac attcgggacc agtctaggaa ctggcttcct     1440

ggaccctgtt accgccagca gcgagtatca aagacatctg cggataacaa caacagtgaa     1500

tactcgtgga ctggagctac caagtaccac ctcaatggca gagactctct ggtgaatccg     1560

ggcccggcca tggcaagcca caaggacgat gaagaaaagt tttttcctca gagcggggtt     1620

ctcatctttg ggaagcaagg ctcagagaaa acaaatgtgg acattgaaaa ggtcatgatt     1680

acagacgaag aggaaatcag gacaaccaat cccgtggcta cggagcagta tggttctgta     1740

tctaccaacc tccagagagg caacagacaa gcagctaccg cagatgtcaa cacacaaggc     1800

gttcttccag gcatggtctg gcaggacaga gatgtgtacc ttcaggggcc catctgggca     1860

aagattccac acacggacgg acattttcac ccctctcccc tcatgggtgg attcggactt     1920

aaacaccctc ctccacagat tctcatcaag aacaccccgg tacctgcgaa tccttcgacc     1980

accttcagtg cggcaaagtt tgcttccttc atcacacagt actccacggg acaggtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaaac gctggaatcc cgaaattcag     2100

tacacttcca actacgccaa gtctgtcaat gtggacttta ctgtggacaa taatggcgtg     2160

tattcagagc ctcgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210>  14
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210>  15
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caggggccag caacgacaac cactacttcg gctacagcac cccctggggg      840

tattttgatt tcaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc      900

aacaacaatt ggggattccg gcccaagaga ctcaacttca aactcttcaa catccaagtc      960

aaggaggtca cgacgaatga tggcgtcaca accatcgcta ataaccttac cagcacggtt     1020

caagtcttct cggactcgga gtaccagctt ccgtacgtcc tcggctctgc gcaccagggc     1080

tgcctccctc cgttcccggc ggacgtgttc atgattccgc aatacggcta cctgacgctc     1140

aacaatggca gccaagccgt gggacgttca tccttttact gcctggaata tttcccttct     1200

cagatgctga gaacgggcaa caactttacc ttcagctaca cctttgagga agtgcctttc     1260

cacagcagct acgcgcacag ccagagcctg gaccggctga tgaatcctct catcgaccaa     1320

tacctgtatt acctgaacag aactcaaaat cagtccggaa gtgcccaaaa caaggacttg     1380

ctgtttagcc gtgggtctcc agctggcatg tctgttcagc ccaaaaactg gctacctgga     1440

ccctgttatc ggcagcagcg cgtttctaaa acaaaaacag acaacaacaa cagcaatttt     1500

acctggactg gtgcttcaaa atataacctc aatgggcgtg aatccatcat caaccctggc     1560

actgctatgg cctcacacaa agacgacgaa gacaagttct ttcccatgag cggtgtcatg     1620

atttttggaa aagagagcgc cggagcttca aacactgcat tggacaatgt catgattaca     1680

gacgaagagg aaattaaagc cactaaccct gtggccaccg aaagatttgg gaccgtggca     1740

gtcaatttcc agagcagcag cacagaccct gcgaccggag atgtgcatgc tatgggagca     1800

ttacctggca tggtgtggca agatagagac gtgtacctgc agggtcccat ttgggccaaa     1860

attcctcaca cagatggaca ctttcacccg tctcctctta tgggcggctt tggactcaag     1920

aacccgcctc ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcggag     1980

ttttcagcta caaagtttgc ttcattcatc acccaatact ccacaggaca agtgagtgtg     2040

gaaattgaat gggagctgca gaaagaaaac agcaagcgct ggaatcccga agtgcagtac     2100

acatccaatt atgcaaaatc tgccaacgtt gattttactg tggacaacaa tggactttat     2160

actgagcctc gccccattgg cacccgttac cttacccgtc ccctgtaa                  2208


<210>  16
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210>  17
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caggggccag caacgacaac cactacttcg gctacagcac cccctggggg      840

tattttgatt tcaacagatt ccactgccat ttctcaccac gtgactggca gcgactcatc      900

aacaacaatt ggggattccg gcccaagaga ctcaacttca agctcttcaa catccaagtc      960

aaggaggtca cgacgaatga tggcgtcacg accatcgcta ataaccttac cagcacggtt     1020

caagtcttct cggactcgga gtaccagttg ccgtacgtcc tcggctctgc gcaccagggc     1080

tgcctccctc cgttcccggc ggacgtgttc atgattccgc agtacggcta cctaacgctc     1140

aacaatggca gccaggcagt gggacggtca tccttttact gcctggaata tttcccatcg     1200

cagatgctga gaacgggcaa taactttacc ttcagctaca ccttcgagga cgtgcctttc     1260

cacagcagct acgcgcacag ccagagcctg gaccggctga tgaatcctct catcgaccag     1320

tacctgtatt acctgaacag aactcagaat cagtccggaa gtgcccaaaa caaggacttg     1380

ctgtttagcc gggggtctcc agctggcatg tctgttcagc ccaaaaactg gctacctgga     1440

ccctgttacc ggcagcagcg cgtttctaaa acaaaaacag acaacaacaa cagcaacttt     1500

acctggactg gtgcttcaaa atataacctt aatgggcgtg aatctataat caaccctggc     1560

actgctatgg cctcacacaa agacgacaaa gacaagttct ttcccatgag cggtgtcatg     1620

atttttggaa aggagagcgc cggagcttca aacactgcat tggacaatgt catgatcaca     1680

gacgaagagg aaatcaaagc cactaacccc gtggccaccg aaagatttgg gactgtggca     1740

gtcaatctcc agagcagcag cacagaccct gcgaccggag atgtgcatgt tatgggagcc     1800

ttacctggaa tggtgtggca agacagagac gtatacctgc agggtcctat ttgggccaaa     1860

attcctcaca cggatggaca ctttcacccg tctcctctca tgggcggctt tggacttaag     1920

cacccgcctc ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag     1980

ttttcggcta caaagtttgc ttcattcatc acccagtatt ccacaggaca agtgagcgtg     2040

gagattgaat gggagctgca gaaagaaaac agcaaacgct ggaatcccga agtgcagtat     2100

acatctaact atgcaaaatc tgccaacgtt gatttcactg tggacaacaa tggactttat     2160

actgagcctc gccccattgg cacccgttac ctcacccgtc ccctgtaa                  2208


<210>  18
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caggggccag caacgacaac cactacttcg gctacagcac cccctggggg      840

tattttgatt tcaacagatt ccactgccat ttctcaccac gtgactggca gcgactcatc      900

aacaacaatt ggggattccg gcccaagaga ctcaacttca agctcttcaa catccaagtc      960

aaggaggtca cgacgaatga tggcgtcacg accatcgcta ataaccttac cagcacggtt     1020

caagtcttct cggactcgga gtaccagttg ccgtacgtcc tcggctctgc gcaccagggc     1080

tgcctccctc cgttcccggc ggacgtgttc atgattccgc agtacggcta cctaacgctc     1140

aacaatggca gccaggcagt gggacggtca tccttttact gcctggaata tttcccatcg     1200

cagatgctga gaacgggcaa taactttacc ttcagctaca ccttcgagga cgtgcctttc     1260

cacagcagct acgcgcacag ccagagcctg gaccggctga tgaatcctct catcgaccag     1320

tacctgtatt acctgaacag aactcagaat cagtccggaa gtgcccaaaa caaggacttg     1380

ctgtttagcc gggggtctcc agctggcatg tctgttcagc ccaaaaactg gctacctgga     1440

ccctgttacc ggcagcagcg cgtttctaaa acaaaaacag acaacaacaa cagcaacttt     1500

acctggactg gtgcttcaaa atataacctt aatgggcgtg aatctataat caaccctggc     1560

actgctatgg cctcacacaa agacgacgaa gacaagttct ttcccatgag cggtgtcatg     1620

atttttggaa aggagagcgc cggagcttca aacactgcat tggacaatgt catgatcaca     1680

gacgaagagg aaatcaaagc cactaacccc gtggccaccg aaagatttgg gactgtggca     1740

gtcaatctcc agagcagcag cacagaccct gcgaccggag atgtgcatgt tatgggagcc     1800

ttacctggaa tggtgtggca agacagagac gtatacctgc agggtcctat ttgggccaaa     1860

attcctcaca cggatggaca ctttcacccg tctcctctca tgggcggctt tggacttaag     1920

cacccgcctc ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag     1980

ttttcggcta caaagtttgc ttcattcatc acccagtatt ccacaggaca agtgagcgtg     2040

gagattgaat gggagctgca gaaagaaaac agcaaacgct ggaatcccga agtgcagtat     2100

acatctaact atgcaaaatc tgccaacgtt gatttcactg tggacaacaa tggactttat     2160

actgagcctc gccccattgg cacccgttac ctcacccgtc ccctgtaa                  2208


<210>  19
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19
atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac      180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc      240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat      300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt      360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg      420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg      480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat      540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa      600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta      660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat      720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct      780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc      840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat      900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg      960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa     1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa     1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat     1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact     1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc     1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg     1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct     1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg     1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact     1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt     1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca     1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga     1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa     1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag     1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg     1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt     1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc     1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa     2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg     2100

atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc     2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac     2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc     2280

ttctcccaga atccaccagt cttgaaacgc catcaacggg aaataactcg tactactctt     2340

cagtcagatc aagaggaaat tgactatgat gataccatat cagttgaaat gaagaaggaa     2400

gattttgaca tttatgatga ggatgaaaat cagagccccc gcagctttca aaagaaaaca     2460

cgacactatt ttattgctgc agtggagagg ctctgggatt atgggatgag tagctcccca     2520

catgttctaa gaaacagggc tcagagtggc agtgtccctc agttcaagaa agttgttttc     2580

caggaattta ctgatggctc ctttactcag cccttatacc gtggagaact aaatgaacat     2640

ttgggactcc tggggccata tataagagca gaagttgaag ataatatcat ggtaactttc     2700

agaaatcagg cctctcgtcc ctattccttc tattctagcc ttatttctta tgaggaagat     2760

cagaggcaag gagcagaacc tagaaaaaac tttgtcaagc ctaatgaaac caaaacttac     2820

ttttggaaag tgcaacatca tatggcaccc actaaagatg agtttgactg caaagcctgg     2880

gcttatttct ctgatgttga cctggaaaaa gatgtgcact caggcctgat tggacccctt     2940

ctggtctgcc acactaacac actgaaccct gctcatggga gacaagtgac agtacaggaa     3000

tttgctctgt ttttcaccat ctttgatgag accaaaagct ggtacttcac tgaaaatatg     3060

gaaagaaact gcagggctcc ctgcaatatc cagatggaag atcccacttt taaagagaat     3120

tatcgcttcc atgcaatcaa tggctacata atggatacac tacctggctt agtaatggct     3180

caggatcaaa ggattcgatg gtatctgctc agcatgggca gcaatgaaaa catccattct     3240

attcatttca gtggacatgt gttcactgta cgaaaaaaag aggagtataa aatggcactg     3300

tacaatctct atccaggtgt ttttgagaca gtggaaatgt taccatccaa agctggaatt     3360

tggcgggtgg aatgccttat tggcgagcat ctacatgctg ggatgagcac actttttctg     3420

gtgtacagca ataagtgtca gactcccctg ggaatggctt ctggacacat tagagatttt     3480

cagattacag cttcaggaca atatggacag tgggccccaa agctggccag acttcattat     3540

tccggatcaa tcaatgcctg gagcaccaag gagccctttt cttggatcaa ggtggatctg     3600

ttggcaccaa tgattattca cggcatcaag acccagggtg cccgtcagaa gttctccagc     3660

ctctacatct ctcagtttat catcatgtat agtcttgatg ggaagaagtg gcagacttat     3720

cgaggaaatt ccactggaac cttaatggtc ttctttggca atgtggattc atctgggata     3780

aaacacaata tttttaaccc tccaattatt gctcgataca tccgtttgca cccaactcat     3840

tatagcattc gcagcactct tcgcatggag ttgatgggct gtgatttaaa tagttgcagc     3900

atgccattgg gaatggagag taaagcaata tcagatgcac agattactgc ttcatcctac     3960

tttaccaata tgtttgccac ctggtctcct tcaaaagctc gacttcacct ccaagggagg     4020

agtaatgcct ggagacctca ggtgaataat ccaaaagagt ggctgcaagt ggacttccag     4080

aagacaatga aagtcacagg agtaactact cagggagtaa aatctctgct taccagcatg     4140

tatgtgaagg agttcctcat ctccagcagt caagatggcc atcagtggac tctctttttt     4200

cagaatggca aagtaaaggt ttttcaggga aatcaagact ccttcacacc tgtggtgaac     4260

tctctagacc caccgttact gactcgctac cttcgaattc acccccagag ttgggtgcac     4320

cagattgccc tgaggatgga ggttctgggc tgcgaggcac aggacctcta ctga           4374


<210>  20
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20

Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr 
1               5                   10                  15      


Arg Gln Lys Gln Phe Asn Ala Thr Pro Pro Val Leu Lys Arg His Gln 
            20                  25                  30          


Arg Glu Ile Thr Arg Thr Thr Leu 
        35                  40  


<210>  21
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg 
1               5                   10                  15      


His Gln Arg Glu Ile Thr Arg Thr Thr Leu 
            20                  25      


<210>  22
<211>  4416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22
atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac      180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc      240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat      300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt      360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg      420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg      480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat      540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa      600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta      660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat      720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct      780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc      840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat      900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg      960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa     1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa     1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat     1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact     1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc     1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg     1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct     1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg     1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact     1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt     1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca     1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga     1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa     1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag     1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg     1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt     1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc     1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa     2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg     2100

atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc     2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac     2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc     2280

ttctcccaga attcaagaca ccctagcact aggcaaaagc aatttaatgc caccccacca     2340

gtcttgaaac gccatcaacg ggaaataact cgtactactc ttcagtcaga tcaagaggaa     2400

attgactatg atgataccat atcagttgaa atgaagaagg aagattttga catttatgat     2460

gaggatgaaa atcagagccc ccgcagcttt caaaagaaaa cacgacacta ttttattgct     2520

gcagtggaga ggctctggga ttatgggatg agtagctccc cacatgttct aagaaacagg     2580

gctcagagtg gcagtgtccc tcagttcaag aaagttgttt tccaggaatt tactgatggc     2640

tcctttactc agcccttata ccgtggagaa ctaaatgaac atttgggact cctggggcca     2700

tatataagag cagaagttga agataatatc atggtaactt tcagaaatca ggcctctcgt     2760

ccctattcct tctattctag ccttatttct tatgaggaag atcagaggca aggagcagaa     2820

cctagaaaaa actttgtcaa gcctaatgaa accaaaactt acttttggaa agtgcaacat     2880

catatggcac ccactaaaga tgagtttgac tgcaaagcct gggcttattt ctctgatgtt     2940

gacctggaaa aagatgtgca ctcaggcctg attggacccc ttctggtctg ccacactaac     3000

acactgaacc ctgctcatgg gagacaagtg acagtacagg aatttgctct gtttttcacc     3060

atctttgatg agaccaaaag ctggtacttc actgaaaata tggaaagaaa ctgcagggct     3120

ccctgcaata tccagatgga agatcccact tttaaagaga attatcgctt ccatgcaatc     3180

aatggctaca taatggatac actacctggc ttagtaatgg ctcaggatca aaggattcga     3240

tggtatctgc tcagcatggg cagcaatgaa aacatccatt ctattcattt cagtggacat     3300

gtgttcactg tacgaaaaaa agaggagtat aaaatggcac tgtacaatct ctatccaggt     3360

gtttttgaga cagtggaaat gttaccatcc aaagctggaa tttggcgggt ggaatgcctt     3420

attggcgagc atctacatgc tgggatgagc acactttttc tggtgtacag caataagtgt     3480

cagactcccc tgggaatggc ttctggacac attagagatt ttcagattac agcttcagga     3540

caatatggac agtgggcccc aaagctggcc agacttcatt attccggatc aatcaatgcc     3600

tggagcacca aggagccctt ttcttggatc aaggtggatc tgttggcacc aatgattatt     3660

cacggcatca agacccaggg tgcccgtcag aagttctcca gcctctacat ctctcagttt     3720

atcatcatgt atagtcttga tgggaagaag tggcagactt atcgaggaaa ttccactgga     3780

accttaatgg tcttctttgg caatgtggat tcatctggga taaaacacaa tatttttaac     3840

cctccaatta ttgctcgata catccgtttg cacccaactc attatagcat tcgcagcact     3900

cttcgcatgg agttgatggg ctgtgattta aatagttgca gcatgccatt gggaatggag     3960

agtaaagcaa tatcagatgc acagattact gcttcatcct actttaccaa tatgtttgcc     4020

acctggtctc cttcaaaagc tcgacttcac ctccaaggga ggagtaatgc ctggagacct     4080

caggtgaata atccaaaaga gtggctgcaa gtggacttcc agaagacaat gaaagtcaca     4140

ggagtaacta ctcagggagt aaaatctctg cttaccagca tgtatgtgaa ggagttcctc     4200

atctccagca gtcaagatgg ccatcagtgg actctctttt ttcagaatgg caaagtaaag     4260

gtttttcagg gaaatcaaga ctccttcaca cctgtggtga actctctaga cccaccgtta     4320

ctgactcgct accttcgaat tcacccccag agttgggtgc accagattgc cctgaggatg     4380

gaggttctgg gctgcgaggc acaggacctc tactga                               4416


