                               SEQUENCE LISTING

<110> ARCTURUS THERAPEUTICS, INC.
 
<120> TRANSTHYRETIN ALLELE SELECTIVE UNA OLIGOMERS FOR GENE SILENCING 

<130> ARC1240WO

<140>
<141>

<150> 61/970,319
<151> 2014-03-25

<160> 72    

<170> PatentIn version 3.5

<210> 1
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> UNA monomer

<220>
<221> modified_base
<222> (2)..(20)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (21)..(22)
<223> UNA monomer

<400> 1
nnnnnnnnnn nnnnnnnnnn nn                                                22


<210> 2
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (2)..(8)
<223> UNA monomer

<220>
<221> modified_base
<222> (9)..(19)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (20)..(21)
<223> UNA monomer

<400> 2
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210> 3
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U6 oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 3
ggccaugcau guguucagau u                                                 21


<210> 4
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U6 oligonucleotide


<220>
<221> modified_base
<222> (6)..(6)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 4
ucugaacaca ugcauggccu u                                                 21


<210> 5
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U7 oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 5
ggccaugcau guguucagau u                                                 21


<210> 6
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U7 oligonucleotide


<220>
<221> modified_base
<222> (7)..(7)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 6
ucugaacaca ugcauggccu u                                                 21


<210> 7
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U14 oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 7
ggccaugcau guguucagau u                                                 21


<210> 8
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U14 oligonucleotide


<220>
<221> modified_base
<222> (14)..(14)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 8
ucugaacaca ugcauggccu u                                                 21


<210> 9
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U15 oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 9
ggccaugcau guguucagau u                                                 21


<210> 10
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U15 oligonucleotide


<220>
<221> modified_base
<222> (15)..(15)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 10
ucugaacaca ugcauggccu u                                                 21


<210> 11
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U16 oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 11
ggccaugcau guguucagau u                                                 21


<210> 12
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U16 oligonucleotide


<220>
<221> modified_base
<222> (16)..(16)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 12
ucugaacaca ugcauggccu u                                                 21


<210> 13
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U6 oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 13
gccaugcaug uguucagaau u                                                 21


<210> 14
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U6 oligonucleotide


<220>
<221> modified_base
<222> (6)..(6)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 14
uucugaacac augcauggcu u                                                 21


<210> 15
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U7 oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 15
gccaugcaug uguucagaau u                                                 21


<210> 16
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U7 oligonucleotide


<220>
<221> modified_base
<222> (7)..(7)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 16
uucugaacac augcauggcu u                                                 21


<210> 17
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U15 oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 17
gccaugcaug uguucagaau u                                                 21


<210> 18
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U15 oligonucleotide


<220>
<221> modified_base
<222> (15)..(15)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 18
uucugaacac augcauggcu u                                                 21


<210> 19
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U16 oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 19
gccaugcaug uguucagaau u                                                 21


<210> 20
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U16 oligonucleotide


<220>
<221> modified_base
<222> (16)..(16)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 20
uucugaacac augcauggcu u                                                 21


<210> 21
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U17 oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 21
gccaugcaug uguucagaau u                                                 21


<210> 22
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U17 oligonucleotide


<220>
<221> modified_base
<222> (17)..(17)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 22
uucugaacac augcauggcu u                                                 21


<210> 23
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30M TTR oligonucleotide

<400> 23
guccugccau caauguggcc augcaugugu ucagaaaggc u                           41


<210> 24
<211> 41
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: wt TTR 
      oligonucleotide

<400> 24
guccugccau caauguggcc gugcaugugu ucagaaaggc u                           41


<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P2 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P2 oligonucleotide

<400> 25
acggccacau ugauggcagt t                                                 21


<210> 26
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P3 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P3 oligonucleotide

<400> 26
cacggccaca uugauggcat t                                                 21


<210> 27
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P4 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P4 oligonucleotide

<400> 27
gcacggccac auugauggct t                                                 21


<210> 28
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P5 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P5 oligonucleotide

<400> 28
ugcacggcca cauugauggt t                                                 21


<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P6 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P6 oligonucleotide

<400> 29
augcacggcc acauugaugt t                                                 21


<210> 30
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P7 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P7 oligonucleotide

<400> 30
caugcacggc cacauugaut t                                                 21


<210> 31
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P8 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P8 oligonucleotide

<400> 31
acaugcacgg ccacauugat t                                                 21


<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P9 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P9 oligonucleotide

<400> 32
cacaugcacg gccacauugt t                                                 21


<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P10 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P10 oligonucleotide

<400> 33
acacaugcac ggccacauut t                                                 21


<210> 34
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P11 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P11 oligonucleotide

<400> 34
aacacaugca cggccacaut t                                                 21


<210> 35
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P12 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P12 oligonucleotide

<400> 35
gaacacaugc acggccacat t                                                 21


<210> 36
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P13 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P13 oligonucleotide

<400> 36
ugaacacaug cacggccact t                                                 21


<210> 37
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P14 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P14 oligonucleotide

<400> 37
cugaacacau gcacggccat t                                                 21


<210> 38
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P15 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P15 oligonucleotide

<400> 38
ucugaacaca ugcacggcct t                                                 21


<210> 39
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30M TTR oligonucleotide

<400> 39
guccugccau caauguggcc augcaugugu ucagaaaggc u                           41


<210> 40
<211> 41
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: wt TTR 
      oligonucleotide

<400> 40
guccugccau caauguggcc gugcaugugu ucagaaaggc u                           41


<210> 41
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P5 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P5 oligonucleotide

<400> 41
ugcacggcca cauugauggt t                                                 21


<210> 42
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P9 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P9 oligonucleotide

<400> 42
cacaugcacg gccacauugt t                                                 21


<210> 43
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P14 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P14 oligonucleotide

<400> 43
cugaacacau gcacggccat t                                                 21


<210> 44
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30V-P15 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30V-P15 oligonucleotide

<400> 44
ucugaacaca ugcacggcct t                                                 21


<210> 45
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30M-P5 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30M-P5 oligonucleotide

<400> 45
ugcauggcca cauugauggt t                                                 21

<210> 46
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30M-P9 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30M-P9 oligonucleotide

<400> 46
cacaugcaug gccacauugt t                                                 21


<210> 47
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30M-P14 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30M-P14 oligonucleotide

<400> 47
cugaacacau gcauggccat t                                                 21


<210> 48
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      V30M-P15 oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      V30M-P15 oligonucleotide

<400> 48
ucugaacaca ugcauggcct t                                                 21


<210> 49
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      siRNA P15 sense oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      siRNA P15 sense oligonucleotide

<400> 49
ggccaugcau guguucagat t                                                 21


<210> 50
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U6 sense oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 50
ggccaugcau guguucagau u                                                 21


<210> 51
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U7 sense oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 51
ggccaugcau guguucagau u                                                 21


<210> 52
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U14 sense oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 52
ggccaugcau guguucagau u                                                 21


<210> 53
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U15 sense oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 53
ggccaugcau guguucagau u                                                 21


<210> 54
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U16 sense oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 54
ggccaugcau guguucagau u                                                 21


<210> 55
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      siRNA P15 antisense oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      siRNA P15 antisense oligonucleotide

<400> 55
ucugaacaca ugcauggcct t                                                 21


<210> 56
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U6 antisense oligonucleotide


<220>
<221> modified_base
<222> (6)..(6)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 56
ucugaacaca ugcauggccu u                                                 21


<210> 57
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U7 antisense oligonucleotide


<220>
<221> modified_base
<222> (7)..(7)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 57
ucugaacaca ugcauggccu u                                                 21


<210> 58
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U14 antisense oligonucleotide


<220>
<221> modified_base
<222> (14)..(14)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 58
ucugaacaca ugcauggccu u                                                 21


<210> 59
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U15 antisense oligonucleotide


<220>
<221> modified_base
<222> (15)..(15)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 59
ucugaacaca ugcauggccu u                                                 21


<210> 60
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P15U16 antisense oligonucleotide


<220>
<221> modified_base
<222> (16)..(16)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 60
ucugaacaca ugcauggccu u                                                 21


<210> 61
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      siRNA P16 sense oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      siRNA P16 sense oligonucleotide

<400> 61
gccaugcaug uguucagaat t                                                 21


<210> 62
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U6 sense oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 62
gccaugcaug uguucagaau u                                                 21


<210> 63
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U7 sense oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 63
gccaugcaug uguucagaau u                                                 21


<210> 64
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U15 sense oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 64
gccaugcaug uguucagaau u                                                 21


<210> 65
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U16 sense oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 65
gccaugcaug uguucagaau u                                                 21


<210> 66
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U17 sense oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 66
gccaugcaug uguucagaau u                                                 21


<210> 67
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      siRNA P16 antisense oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      siRNA P16 antisense oligonucleotide

<400> 67
uucugaacac augcauggct t                                                 21


<210> 68
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U6 antisense oligonucleotide


<220>
<221> modified_base
<222> (6)..(6)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 68
uucugaacac augcauggcu u                                                 21


<210> 69
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U7 antisense oligonucleotide


<220>
<221> modified_base
<222> (7)..(7)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 69
uucugaacac augcauggcu u                                                 21


<210> 70
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U15 antisense oligonucleotide


<220>
<221> modified_base
<222> (15)..(15)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 70
uucugaacac augcauggcu u                                                 21


<210> 71
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U16 antisense oligonucleotide


<220>
<221> modified_base
<222> (16)..(16)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 71
uucugaacac augcauggcu u                                                 21


<210> 72
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      P16U17 antisense oligonucleotide


<220>
<221> modified_base
<222> (17)..(17)
<223> Non-nucleotide monomer

<220>
<221> modified_base
<222> (20)..(20)
<223> Non-nucleotide monomer

<400> 72
uucugaacac augcauggcu u                                                 21




