                         SEQUENCE LISTING

<110>  Children's Medical Center Corporation
 
<120>  CYCLIC PROSAPOSIN PEPTIDES AND USES THEREOF

<130>  C1233.70077WO00

<150>  US 61/970,853
<151>  2014-03-26

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Asp Trp Leu Pro Lys 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Asp Trp Gly Pro Lys 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Asp is a D-amino acid 

<400>  3

Asp Trp Leu Pro Lys 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Asp is a D-amino acid 

<400>  4

Asp Trp Gly Pro Lys 
1               5   


<210>  5
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Asp is a D-amino acid 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Leu is a D-amino acid 

<400>  5

Asp Trp Leu Pro 
1               


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Asp Trp Leu Pro 
1               


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Trp is a D-amino acid 

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Pro is a D-amino acid

<400>  7

Asp Trp Leu Pro 
1               


<210>  8
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (6)..(40)
<223>  these amino acids may be absent

<400>  8

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210>  9
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala 
1               5                   10                  15      


Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp 
            20                  25                  30          


Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys 
        35                  40                  45              


Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp 
    50                  55                  60                  


Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn 
65                  70                  75                  80  


Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp 
                85                  90                  95      


Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser 
            100                 105                 110         


Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro 
        115                 120                 125             


Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His 
    130                 135                 140                 


Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro 
145                 150                 155                 160 


Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro 
                165                 170                 175     


Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys 
            180                 185                 190         


Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile 
        195                 200                 205             


Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu 
    210                 215                 220                 


His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile 
225                 230                 235                 240 


Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met 
                245                 250                 255     


Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp 
            260                 265                 270         


Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala 
        275                 280                 285             


Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys 
    290                 295                 300                 


His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe 
305                 310                 315                 320 


Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys 
                325                 330                 335     


Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser 
            340                 345                 350         


Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile 
        355                 360                 365             


Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met 
    370                 375                 380                 


Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val 
385                 390                 395                 400 


Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val 
                405                 410                 415     


Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile 
            420                 425                 430         


Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln 
        435                 440                 445             


Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu 
    450                 455                 460                 


Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly 
465                 470                 475                 480 


Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile 
                485                 490                 495     


Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys 
            500                 505                 510         


Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn 
        515                 520                 


<210>  10
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala 
1               5                   10                  15      


Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp 
            20                  25                  30          


Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys 
        35                  40                  45              


Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp 
    50                  55                  60                  


Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn 
65                  70                  75                  80  


Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp 
                85                  90                  95      


Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser 
            100                 105                 110         


Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro 
        115                 120                 125             


Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His 
    130                 135                 140                 


Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro 
145                 150                 155                 160 


Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro 
                165                 170                 175     


Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys 
            180                 185                 190         


Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile 
        195                 200                 205             


Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu 
    210                 215                 220                 


His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile 
225                 230                 235                 240 


Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met 
                245                 250                 255     


Met His Met Gln Asp Gln Gln Pro Lys Glu Ile Cys Ala Leu Val Gly 
            260                 265                 270         


Phe Cys Asp Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala 
        275                 280                 285             


Lys Val Ala Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro 
    290                 295                 300                 


Ile Lys Lys His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val 
305                 310                 315                 320 


Cys Glu Phe Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys 
                325                 330                 335     


Thr Glu Lys Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu 
            340                 345                 350         


Pro Lys Ser Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly 
        355                 360                 365             


Ser Ser Ile Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val 
    370                 375                 380                 


Cys Ser Met Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr 
385                 390                 395                 400 


Val His Val Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys 
                405                 410                 415     


Lys Leu Val Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys 
            420                 425                 430         


Gln Glu Ile Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp 
        435                 440                 445             


Pro Tyr Gln Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val 
    450                 455                 460                 


Leu Ile Glu Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu 
465                 470                 475                 480 


Lys Ile Gly Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu 
                485                 490                 495     


Lys Cys Ile Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala 
            500                 505                 510         


Ala Gln Cys Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn 
        515                 520                 525         


<210>  11
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala 
1               5                   10                  15      


Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp 
            20                  25                  30          


Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys 
        35                  40                  45              


Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp 
    50                  55                  60                  


Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn 
65                  70                  75                  80  


Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp 
                85                  90                  95      


Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser 
            100                 105                 110         


Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro 
        115                 120                 125             


Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His 
    130                 135                 140                 


Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro 
145                 150                 155                 160 


Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro 
                165                 170                 175     


Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys 
            180                 185                 190         


Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile 
        195                 200                 205             


Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu 
    210                 215                 220                 


His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile 
225                 230                 235                 240 


Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met 
                245                 250                 255     


Met His Met Asp Gln Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe 
            260                 265                 270         


Cys Asp Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys 
        275                 280                 285             


Val Ala Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile 
    290                 295                 300                 


Lys Lys His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys 
305                 310                 315                 320 


Glu Phe Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr 
                325                 330                 335     


Glu Lys Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro 
            340                 345                 350         


Lys Ser Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser 
        355                 360                 365             


Ser Ile Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys 
    370                 375                 380                 


Ser Met Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val 
385                 390                 395                 400 


His Val Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys 
                405                 410                 415     


Leu Val Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln 
            420                 425                 430         


Glu Ile Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro 
        435                 440                 445             


Tyr Gln Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu 
    450                 455                 460                 


Ile Glu Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys 
465                 470                 475                 480 


Ile Gly Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys 
                485                 490                 495     


Cys Ile Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala 
            500                 505                 510         


Gln Cys Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn 
        515                 520                 525     


<210>  12
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Ser Leu Pro Cys Asp Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp 
1               5                   10                  15      


Met Leu Lys Asp Asn Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu 
            20                  25                  30          


Lys Thr Cys Asp Trp Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys 
        35                  40                  45              


Glu Ile Val Asp Ser Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly 
    50                  55                  60                  


Glu Met Ser Arg Pro Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu 
65                  70                  75                  80  


Ser 
    


