                         SEQUENCE LISTING

<110>  UCL Business PLC
 
<120>  Signalling system

<130>  P104247PCT

<150>  GB 1405845.7
<151>  2014-04-01

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemical inducer of dimerization (CID) binding domain - FKBP12 
       domain

<400>  1

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210>  2
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CID binding domain - wild-type FRB segment of mTOR

<400>  2

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  3
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CID binding domain - FRB with T to L substitution at 2098 which 
       allows binding to AP21967

<400>  3

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  4
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CID binding domain - FRB segment of mTOR

<400>  4

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu His Gln Ala Phe Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  5
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CID binding domain - FRB segment of mTOR

<400>  5

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Pro Asp 
65                  70                  75                  80  


Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  6

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Gly 
            20      


<210>  7
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  7

Met Ser Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  8
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  8

Met Ala Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys 
            20  


<210>  9
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer (hinge-CH2CH3 of human IgG1)

<400>  9

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230                 


<210>  10
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer (human CD8 stalk)

<400>  10

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer (human IgG1 hinge)

<400>  11

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Lys Asp Pro Lys 
            20  


<210>  12
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer (CD2 ectodomain)

<400>  12

Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly Ala Leu Gly Gln Asp 
1               5                   10                  15      


Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser Asp Asp Ile Asp Asp 
            20                  25                  30          


Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys Ile Ala Gln Phe Arg 
        35                  40                  45              


Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr Tyr Lys Leu Phe Lys 
    50                  55                  60                  


Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr Asp Asp Gln Asp Ile 
65                  70                  75                  80  


Tyr Lys Val Ser Ile Tyr Asp Thr Lys Gly Lys Asn Val Leu Glu Lys 
                85                  90                  95      


Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser 
            100                 105                 110         


Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu Val Met Asn Gly Thr 
        115                 120                 125             


Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys His Leu Lys Leu Ser 
    130                 135                 140                 


Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser Leu Ser Ala Lys Phe 
145                 150                 155                 160 


Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu Ser Ser Val Glu Pro 
                165                 170                 175     


Val Ser Cys Pro Glu Lys Gly Leu Asp 
            180                 185 


<210>  13
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer (CD34 ectodomain)

<400>  13

Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly 
1               5                   10                  15      


Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr 
            20                  25                  30          


Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly 
        35                  40                  45              


Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser 
    50                  55                  60                  


Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln 
65                  70                  75                  80  


Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val 
                85                  90                  95      


Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val 
            100                 105                 110         


Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys 
        115                 120                 125             


Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile 
    130                 135                 140                 


Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu 
145                 150                 155                 160 


Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly 
                165                 170                 175     


Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp 
            180                 185                 190         


Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg 
        195                 200                 205             


Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser 
    210                 215                 220                 


Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly 
225                 230                 235                 240 


Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser 
                245                 250                 255     


Gln Lys Thr 
            


<210>  14
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signalling component CD3 Z endodomain

<400>  14

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  15
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signalling component CD28 and CD3 Zeta endodomains

<400>  15

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
        35                  40                  45              


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
65                  70                  75                  80  


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                85                  90                  95      


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            100                 105                 110         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        115                 120                 125             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    130                 135                 140                 


His Met Gln Ala Leu Pro Pro Arg 
145                 150         


<210>  16
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signalling component CD28, OX40 and CD3 Zeta endodomains

<400>  16

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp 
        35                  40                  45              


Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
    50                  55                  60                  


Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe 
65                  70                  75                  80  


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                85                  90                  95      


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            100                 105                 110         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        115                 120                 125             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    130                 135                 140                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
145                 150                 155                 160 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                165                 170                 175     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            180                 185             


<210>  17
<211>  20
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  17

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  18

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  19
<211>  3549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Simple inducible Chimeric Antigen Receptor (CAR)

<400>  19
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg cagcaccggc       60

gacatccaga tgacccagac caccagcagc ctgagcgcca gcctgggcga ccgggtgacc      120

atcagctgca gagccagcca ggacatcagc aagtacctga actggtacca gcagaagccc      180

gacggcaccg tgaagctgct gatctaccac accagccggc tgcacagcgg cgtgcccagc      240

cggttcagcg gcagcggcag cggcaccgac tacagcctga ccatcagcaa cctggagcag      300

gaggacatcg ccacctactt ctgccagcag ggcaacaccc tgccctacac cttcggaggc      360

ggcaccaagc tggagatcac caaggccgga ggcggaggct ctggcggagg cggctctggc      420

ggaggcggct ctggcggagg cggcagcgag gtgaagctgc aggagtctgg cccaggcctg      480

gtggccccaa gccagagcct gagcgtgacc tgcaccgtga gcggcgtgag cctgcccgac      540

tacggcgtga gctggatcag gcagccccca cggaagggcc tggagtggct gggcgtgatc      600

tggggcagcg agaccaccta ctacaacagc gccctgaaga gccggctgac catcatcaag      660

gacaacagca agagccaggt gttcctgaag atgaacagcc tgcagaccga cgacaccgcc      720

atctactact gcgccaagca ctactactat ggcggcagct acgctatgga ctactggggc      780

cagggcacca gcgtgaccgt gagctcggat cccgccgagc ccaaatctcc tgacaaaact      840

cacacatgcc caccgtgccc agcacctccc gtggccggcc cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatcgcc cggacccctg aggtcacatg cgtggtggtg      960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1320

gggcaaccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1440

tgctccgtga tgcatgaggc cctgcacaat cactataccc agaaatctct gagtctgagc     1500

ccaggcaaga aggaccccaa gttctgggtc ctggtggtgg tgggaggcgt gctggcctgt     1560

tactctctcc tggtgaccgt ggccttcatc atcttctggg tgggagtgca ggtggaaacc     1620

atctccccag gagacgggcg caccttcccc aagcgcggcc agacctgcgt ggtgcactac     1680

accgggatgc ttgaagatgg aaagaaattc gattcctccc gggacagaaa caagcccttt     1740

aagtttatgc taggcaagca ggaggtgatc cgaggctggg aagaaggggt tgcccagatg     1800

agtgtgggtc agagagccaa actgactata tctccagatt atgcctatgg tgccactggg     1860

cacccaggca tcatcccacc acatgccact ctcgtcttcg atgtggagct tctaaaactg     1920

gaacgcgcag agggccgggg ctcattgctg acctgtggag atgtcgagga aaatcccggc     1980

ccaatggctt ctagaatcct ctggcatgag atgtggcatg aaggcctgga agaggcatct     2040

cgtttgtact ttggggaaag gaacgtgaaa ggcatgtttg aggtgctgga gcccttgcat     2100

gctatgatgg aacggggccc ccagactctg aaggaaacat cctttaatca ggcctatggt     2160

cgagatttaa tggaggccca agagtggtgc aggaagtaca tgaaatcagg gaatgtcaag     2220

gacctcctcc aagcctggga cctctattat catgtgttcc gacgaatctc aaagctcgag     2280

agtggcggag gaggcagttc aaggtccgcc gacgcgcctg cataccagca ggggcagaat     2340

cagctgtaca acgagctcaa cctcggtagg cgcgaggaat acgatgtgct cgataagaga     2400

agaggtcgcg atcccgagat gggaggaaaa cctcagcgcc gcaagaaccc tcaggagggg     2460

ctgtataacg aactgcagaa ggataagatg gcagaggcct actccgagat tggcatgaag     2520

ggtgagagga gaagaggtaa aggccatgac ggcctctacc aaggcctctc taccgcaacg     2580

aaagacactt atgacgctct gcatatgcag gctctccccc ctaggcagtg cactaattac     2640

gcccttctga aacttgccgg cgatgtggag tctaaccctg gccctatcct gtggcacgag     2700

atgtggcatg agggtctgga agaggccagc cggctgtact tcggagagag aaatgttaag     2760

ggtatgttcg aggtgctgga gccgcttcac gctatgatgg agaggggccc ccagaccctc     2820

aaagaaacca gcttcaatca agcctacggg agggatctta tggaggcaca ggaatggtgt     2880

cggaagtaca tgaagagcgg gaacgtcaag gacctgctcc aggcttggga tttgtattat     2940

cacgtcttta ggcggatcag caagtctgga ggcggaggaa gtctgcacag cgattacatg     3000

aacatgaccc cccgaaggcc cggacccaca cgcaaacact atcaacccta tgctccccca     3060

cgcgacttcg ccgcctaccg gtcacgcgcc gaggggcgcg gctctttgtt gacttgcggg     3120

gacgttgaag agaatcctgg ccccatcctt tggcacgaga tgtggcacga gggcctggag     3180

gaagcctccc ggctgtattt cggagagcgc aacgtcaaag gaatgtttga ggtgctggag     3240

cctctccatg caatgatgga gagggggcct cagactctta aagaaacatc ctttaatcag     3300

gcttacggta gagatttgat ggaggctcaa gaatggtgcc ggaaatacat gaagagtgga     3360

aacgttaaag acctgctgca ggcatgggac ctgtactatc acgtattcag acggatctca     3420

aagtcagggg gcggtggctc cctttatatc ttcaagcagc ctttcatgag gccggtgcag     3480

accacacaag aagaggatgg gtgctcttgc cggttccccg aggaggagga gggcggatgc     3540

gagctctga                                                             3549


<210>  20
<211>  4266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inducible CAR

<400>  20
atgagcctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgccaga       60

ccagacatcc agatgaccca gaccaccagc agcctgagcg ccagcctggg cgaccgggtg      120

accatcagct gcagagccag ccaggacatc agcaagtacc tgaactggta ccagcagaag      180

cccgacggca ccgtgaagct gctgatctac cacaccagcc ggctgcacag cggcgtgccc      240

agccggttca gcggcagcgg cagcggcacc gactacagcc tgaccatcag caacctggag      300

caggaggaca tcgccaccta cttctgccag cagggcaaca ccctgcccta caccttcgga      360

ggcggcacca agctggagat caccaaggcc ggaggcggag gctctggcgg aggcggctct      420

ggcggaggcg gctctggcgg aggcggcagc gaggtgaagc tgcaggagtc tggcccaggc      480

ctggtggccc caagccagag cctgagcgtg acctgcaccg tgagcggcgt gagcctgccc      540

gactacggcg tgagctggat caggcagccc ccacggaagg gcctggagtg gctgggcgtg      600

atctggggca gcgagaccac ctactacaac agcgccctga agagccggct gaccatcatc      660

aaggacaaca gcaagagcca ggtgttcctg aagatgaaca gcctgcagac cgacgacacc      720

gccatctact actgcgccaa gcactactac tatggcggca gctacgctat ggactactgg      780

ggccagggca ccagcgtgac cgtgagctca gatcccacca cgacgccagc gccgcgacca      840

ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg      900

ccagcggcgg ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatcttttgg      960

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttc     1020

atcatcttct gggtgggagt gcaggtggaa accatctccc caggagacgg gcgcaccttc     1080

cccaagcgcg gccagacctg cgtggtgcac tacaccggga tgcttgaaga tggaaagaaa     1140

ttcgattcct cccgggacag aaacaagccc tttaagttta tgctaggcaa gcaggaggtg     1200

atccgaggct gggaagaagg ggttgcccag atgagtgtgg gtcagagagc caaactgact     1260

atatctccag attatgccta tggtgccact gggcacccag gcatcatccc accacatgcc     1320

actctcgtct tcgatgtgga gcttctaaaa ctggaacgag ccgagggcag gggaagtctt     1380

ctaacatgcg gggacgtgga ggaaaatccc gggcccatgg agaccgacac cctgctgctg     1440

tgggtgctgc tgctgtgggt gcccggcagc accggccagg tgcagctgca gcagcccggc     1500

gccgagctgg tgaagcccgg cgccagcgtg aagatgagct gcaaggccag cggctacacc     1560

ttcaccagct acaacatgca ctgggtgaag cagacccccg gccggggcct ggagtggatc     1620

ggcgccatct accccggcaa cggcgacacc agctacaacc agaagttcaa gggcaaggcc     1680

accctgaccg ccgacaagag cagcagcacc gcctacatgc agctgagcag cctgaccagc     1740

gaggacagcg ccgtgtacta ctgcgcccgg agcacctact acggcggcga ctggtacttc     1800

aacgtgtggg gcgccggcac caccgtgacc gtgagcggag gcggcggcag cggaggaggc     1860

ggctctgggg gaggcggatc tcagatcgtg ctgagccaga gccccgccat cctgagcgcc     1920

agccccggcg agaaggtgac catgacctgc cgggccagca gcagcgtgag ctacatccac     1980

tggttccagc agaagcccgg cagcagcccc aagccctgga tctacgccac cagcaacctg     2040

gccagcggcg tgcccgtgcg gttcagcggc agcggcagcg gcaccagcta cagcctgacc     2100

atcagccggg tggaggccga ggacgccgcc acctactact gccagcagtg gaccagcaac     2160

ccacccacct tcggcggcgg caccaagctg gagatcaagc ggtcggatcc cgccgagccc     2220

aaatctcctg acaaaactca cacatgccca ccgtgcccag cacctcccgt ggccggcccg     2280

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatcgcccg gacccctgag     2340

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac     2400

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc     2460

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     2520

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     2580

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     2640

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     2700

gtggagtggg agagcaatgg gcaaccggag aacaactaca agaccacgcc tcccgtgctg     2760

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     2820

caggggaacg tcttctcatg ctccgtgatg catgaggccc tgcacaatca ctatacccag     2880

aaatctctga gtctgagccc aggcaagaag gaccccaagt tctgggtcct ggtggtggtg     2940

ggaggcgtgc tggcctgtta ctctctcctg gtgaccgtgg ccttcatcat cttctgggtg     3000

ggagtgcagg tggaaaccat ctccccagga gacgggcgca ccttccccaa gcgcggccag     3060

acctgcgtgg tgcactacac cgggatgctt gaagatggaa agaaattcga ttcctcccgg     3120

gacagaaaca agccctttaa gtttatgcta ggcaagcagg aggtgatccg aggctgggaa     3180

gaaggggttg cccagatgag tgtgggtcag agagccaaac tgactatatc tccagattat     3240

gcctatggtg ccactgggca cccaggcatc atcccaccac atgccactct cgtcttcgat     3300

gtggagcttc taaaactgga acgcgcagag ggccggggct cattgctgac ctgtggagat     3360

gtcgaggaaa atcccggccc aatggcttct agaatcctct ggcatgagat gtggcatgaa     3420

ggcctggaag aggcatctcg tttgtacttt ggggaaagga acgtgaaagg catgtttgag     3480

gtgctggagc ccttgcatgc tatgatggaa cggggccccc agactctgaa ggaaacatcc     3540

tttaatcagg cctatggtcg agatttaatg gaggcccaag agtggtgcag gaagtacatg     3600

aaatcaggga atgtcaagga cctcctccaa gcctgggacc tctattatca tgtgttccga     3660

cgaatctcaa agctcgagta tagcggcggc ggcagcagga gtaagaggag caggctcctg     3720

cacagtgact acatgaacat gactccccgc cgccccgggc ccacccgcaa gcattaccag     3780

ccctatgccc caccacgcga cttcgcagcc tatcgctcca gggaccagag gctgcccccc     3840

gatgcccaca agccccctgg gggaggcagt ttccggaccc ccatccaaga ggagcaggcc     3900

gacgcccact ccaccctggc caagatcaga gtgaagttca gcaggagcgc agacgccccc     3960

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     4020

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     4080

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     4140

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     4200

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgcctcct     4260

cgctaa                                                                4266


<210>  21
<211>  3549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inducible CAR

<400>  21
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg cagcaccggc       60

gacatccaga tgacccagac caccagcagc ctgagcgcca gcctgggcga ccgggtgacc      120

atcagctgca gagccagcca ggacatcagc aagtacctga actggtacca gcagaagccc      180

gacggcaccg tgaagctgct gatctaccac accagccggc tgcacagcgg cgtgcccagc      240

cggttcagcg gcagcggcag cggcaccgac tacagcctga ccatcagcaa cctggagcag      300

gaggacatcg ccacctactt ctgccagcag ggcaacaccc tgccctacac cttcggaggc      360

ggcaccaagc tggagatcac caaggccgga ggcggaggct ctggcggagg cggctctggc      420

ggaggcggct ctggcggagg cggcagcgag gtgaagctgc aggagtctgg cccaggcctg      480

gtggccccaa gccagagcct gagcgtgacc tgcaccgtga gcggcgtgag cctgcccgac      540

tacggcgtga gctggatcag gcagccccca cggaagggcc tggagtggct gggcgtgatc      600

tggggcagcg agaccaccta ctacaacagc gccctgaaga gccggctgac catcatcaag      660

gacaacagca agagccaggt gttcctgaag atgaacagcc tgcagaccga cgacaccgcc      720

atctactact gcgccaagca ctactactat ggcggcagct acgctatgga ctactggggc      780

cagggcacca gcgtgaccgt gagctcggat cccgccgagc ccaaatctcc tgacaaaact      840

cacacatgcc caccgtgccc agcacctccc gtggccggcc cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatcgcc cggacccctg aggtcacatg cgtggtggtg      960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1320

gggcaaccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1440

tgctccgtga tgcatgaggc cctgcacaat cactataccc agaaatctct gagtctgagc     1500

ccaggcaaga aggaccccaa gttctgggtc ctggtggtgg tgggaggcgt gctggcctgt     1560

tactctctcc tggtgaccgt ggccttcatc atcttctggg tgggagtgca ggtggaaacc     1620

atctccccag gagacgggcg caccttcccc aagcgcggcc agacctgcgt ggtgcactac     1680

accgggatgc ttgaagatgg aaagaaattc gattcctccc gggacagaaa caagcccttt     1740

aagtttatgc taggcaagca ggaggtgatc cgaggctggg aagaaggggt tgcccagatg     1800

agtgtgggtc agagagccaa actgactata tctccagatt atgcctatgg tgccactggg     1860

cacccaggca tcatcccacc acatgccact ctcgtcttcg atgtggagct tctaaaactg     1920

gaacgcgcag agggccgggg ctcattgctg acctgtggag atgtcgagga aaatcccggc     1980

ccaatggctt ctagaatcct ctggcatgag atgtggcatg aaggcctgga agaggcatct     2040

cgtttgtact ttggggaaag gaacgtgaaa ggcatgtttg aggtgctgga gcccttgcat     2100

gctatgatgg aacggggccc ccagactctg aaggaaacat cctttaatca ggcctatggt     2160

cgagatttaa tggaggccca agagtggtgc aggaagtaca tgaaatcagg gaatgtcaag     2220

gacctcctcc aagcctggga cctctattat catgtgttcc gacgaatctc aaagctcgag     2280

agtggcggag gaggcagttc aaggtccgcc gacgcgcctg cataccagca ggggcagaat     2340

cagctgtaca acgagctcaa cctcggtagg cgcgaggaat acgatgtgct cgataagaga     2400

agaggtcgcg atcccgagat gggaggaaaa cctcagcgcc gcaagaaccc tcaggagggg     2460

ctgtataacg aactgcagaa ggataagatg gcagaggcct actccgagat tggcatgaag     2520

ggtgagagga gaagaggtaa aggccatgac ggcctctacc aaggcctctc taccgcaacg     2580

aaagacactt atgacgctct gcatatgcag gctctccccc ctaggcagtg cactaattac     2640

gcccttctga aacttgccgg cgatgtggag tctaaccctg gccctatcct gtggcacgag     2700

atgtggcatg agggtctgga agaggccagc cggctgtact tcggagagag aaatgttaag     2760

ggtatgttcg aggtgctgga gccgcttcac gctatgatgg agaggggccc ccagaccctc     2820

aaagaaacca gcttcaatca agcctacggg agggatctta tggaggcaca ggaatggtgt     2880

cggaagtaca tgaagagcgg gaacgtcaag gacctgctcc aggcttggga tttgtattat     2940

cacgtcttta ggcggatcag caagtctgga ggcggaggaa gtctgcacag cgattacatg     3000

aacatgaccc cccgaaggcc cggacccaca cgcaaacact atcaacccta tgctccccca     3060

cgcgacttcg ccgcctaccg gtcacgcgcc gaggggcgcg gctctttgtt gacttgcggg     3120

gacgttgaag agaatcctgg ccccatcctt tggcacgaga tgtggcacga gggcctggag     3180

gaagcctccc ggctgtattt cggagagcgc aacgtcaaag gaatgtttga ggtgctggag     3240

cctctccatg caatgatgga gagggggcct cagactctta aagaaacatc ctttaatcag     3300

gcttacggta gagatttgat ggaggctcaa gaatggtgcc ggaaatacat gaagagtgga     3360

aacgttaaag acctgctgca ggcatgggac ctgtactatc acgtattcag acggatctca     3420

aagtcagggg gcggtggctc cctttatatc ttcaagcagc ctttcatgag gccggtgcag     3480

accacacaag aagaggatgg gtgctcttgc cggttccccg aggaggagga gggcggatgc     3540

gagctctga                                                             3549


<210>  22
<211>  3993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inducible CAR

<400>  22
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg cagcaccggc       60

gacatccaga tgacccagac caccagcagc ctgagcgcca gcctgggcga ccgggtgacc      120

atcagctgca gagccagcca ggacatcagc aagtacctga actggtacca gcagaagccc      180

gacggcaccg tgaagctgct gatctaccac accagccggc tgcacagcgg cgtgcccagc      240

cggttcagcg gcagcggcag cggcaccgac tacagcctga ccatcagcaa cctggagcag      300

gaggacatcg ccacctactt ctgccagcag ggcaacaccc tgccctacac cttcggaggc      360

ggcaccaagc tggagatcac caaggccgga ggcggaggct ctggcggagg cggctctggc      420

ggaggcggct ctggcggagg cggcagcgag gtgaagctgc aggagtctgg cccaggcctg      480

gtggccccaa gccagagcct gagcgtgacc tgcaccgtga gcggcgtgag cctgcccgac      540

tacggcgtga gctggatcag gcagccccca cggaagggcc tggagtggct gggcgtgatc      600

tggggcagcg agaccaccta ctacaacagc gccctgaaga gccggctgac catcatcaag      660

gacaacagca agagccaggt gttcctgaag atgaacagcc tgcagaccga cgacaccgcc      720

atctactact gcgccaagca ctactactat ggcggcagct acgctatgga ctactggggc      780

cagggcacca gcgtgaccgt gagctcggat cccgccgagc ccaaatctcc tgacaaaact      840

cacacatgcc caccgtgccc agcacctccc gtggccggcc cgtcagtctt cctcttcccc      900

ccaaaaccca aggacaccct catgatcgcc cggacccctg aggtcacatg cgtggtggtg      960

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1020

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1080

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     1140

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1200

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1260

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1320

gggcaaccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1380

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1440

tgctccgtga tgcatgaggc cctgcacaat cactataccc agaaatctct gagtctgagc     1500

ccaggcaaga aggaccccaa gttctgggtc ctggtggtgg tgggaggcgt gctggcctgt     1560

tactctctcc tggtgaccgt ggccttcatc atcttctggg tgatcctctg gcatgagatg     1620

tggcatgaag gcctggaaga ggcatctcgt ttgtactttg gggaaaggaa cgtgaaaggc     1680

atgtttgagg tgctggagcc cttgcatgct atgatggaac ggggccccca gactctgaag     1740

gaaacatcct ttaatcaggc ctatggtcga gatttaatgg aggcccaaga gtggtgcagg     1800

aagtacatga aatcagggaa tgtcaaggac ctcctccaag cctgggacct ctattatcat     1860

gtgttccgac gaatctcaaa gagcagcctg gtgggaccca cccagagctt cttcatgcgg     1920

gagagcaaga ccctgggagc cgtgcagatc atgaacggcc tgttccacat cgccctggga     1980

ggcctgctga tgatccctgc cggcatctac gccccaatct gcgtgaccgt gtggtaccca     2040

ctgtggggag gcatcatgta catcatcagc ggcagcctgc tggccgccac cgagaagaac     2100

agcggagggg gaagcatcct gtggcacgag atgtggcatg agggtctgga agaggccagc     2160

cggctgtact tcggagagag aaatgttaag ggtatgttcg aggtgctgga gccgcttcac     2220

gctatgatgg agaggggccc ccagaccctc aaagaaacca gcttcaatca agcctacggg     2280

agggatctta tggaggcaca ggaatggtgt cggaagtaca tgaagagcgg gaacgtcaag     2340

gacctgctcc aggcttggga tttgtattat cacgtcttta ggcggatcag caagtctgga     2400

ggcggaggaa gtcggaagtg cctggtgaag ggcaagatga tcatgaacag cctgagcctg     2460

ttcgccgcca tcagcggcat gatcctgagc atcatggaca tcctgaacat caagatcagc     2520

cacttcctga agatggagag cctgaacttc atccgggccc acaccccata catcaacatc     2580

tacaactgcg agcctgccaa ccccagcgag aagaacagcc ccagcaccca gtactgctac     2640

agcatccaga gcctgttcct gggcatcctg agcgtgatgc tgatcttcgc cttcttccag     2700

gagctggtga tcgccggcat cgtggagaac gagtggaagc ggacctgcag ccggcccaag     2760

agcatcctgt ggcacgagat gtggcatgag ggtctggaag aggccagccg gctgtacttc     2820

ggagagagaa atgttaaggg tatgttcgag gtgctggagc cgcttcacgc tatgatggag     2880

aggggccccc agaccctcaa agaaaccagc ttcaatcaag cctacgggag ggatcttatg     2940

gaggcacagg aatggtgtcg gaagtacatg aagagcggga acgtcaagga cctgctccag     3000

gcttgggatt tgtattatca cgtctttagg cggatcagca agcgcgcaga gggccggggc     3060

tcattgctga cctgtggaga tgtcgaggaa aatcccggcc caggagtgca ggtggaaacc     3120

atctccccag gagacgggcg caccttcccc aagcgcggcc agacctgcgt ggtgcactac     3180

accgggatgc ttgaagatgg aaagaaattc gattcctccc gggacagaaa caagcccttt     3240

aagtttatgc taggcaagca ggaggtgatc cgaggctggg aagaaggggt tgcccagatg     3300

agtgtgggtc agagagccaa actgactata tctccagatt atgcctatgg tgccactggg     3360

cacccaggca tcatcccacc acatgccact ctcgtcttcg atgtggagct tctaaaactg     3420

gaaaggagta agaggagcag gctcctgcac agtgactaca tgaacatgac tccccgccgc     3480

cccgggccca cccgcaagca ttaccagccc tatgccccac cacgcgactt cgcagcctat     3540

cgctccaggg accagaggct gccccccgat gcccacaagc cccctggggg aggcagtttc     3600

cggaccccca tccaagagga gcaggccgac gcccactcca ccctggccaa gatcagagtg     3660

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     3720

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     3780

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     3840

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     3900

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     3960

gcccttcaca tgcaggccct gcctcctcgc tga                                  3993


<210>  23
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Simple inducible CAR

<400>  23

Met Pro Val Asp Arg Ile Leu Glu Ala Glu Leu Ala Val Glu Gln Lys 
1               5                   10                  15      


Ser Asp Gln Gly Val Glu Gly Pro Gly Gly Thr Gly Gly Ser Gly Ser 
            20                  25                  30          


Ser Pro Asn Asp Pro Val Thr Asn Ile Cys Gln Ala Ala Asp Lys Gln 
        35                  40                  45              


Leu Phe Thr Leu Val Glu Trp Ala Lys Arg Ile Pro His Phe Ser Ser 
    50                  55                  60                  


Leu Pro Leu Asp Asp Gln Val Ile Leu Leu Arg Ala Gly Trp Asn Glu 
65                  70                  75                  80  


Leu Leu Ile Ala Ser Phe Ser His Arg Ser Ile Asp Val Arg Asp Gly 
                85                  90                  95      


Ile Leu Leu Ala Thr Gly Leu His Val His Arg Asn Ser Ala His Ser 
            100                 105                 110         


Ala Gly Val Gly Ala Ile Phe Asp Arg Val Leu Thr Glu Leu Val Ser 
        115                 120                 125             


Lys Met Arg Asp Met Arg Met Asp Lys Thr Glu Leu Gly Cys Leu Arg 
    130                 135                 140                 


Ala Ile Ile Leu Phe Asn Pro Glu Val Arg Gly Leu Lys Ser Ala Gln 
145                 150                 155                 160 


Glu Val Glu Leu Leu Arg Glu Lys Val Tyr Ala Ala Leu Glu Glu Tyr 
                165                 170                 175     


Thr Arg Thr Thr His Pro Asp Glu Pro Gly Arg Phe Ala Lys Leu Leu 
            180                 185                 190         


Leu Arg Leu Pro Ser Leu Arg Ser Ile Gly Leu Lys Cys Leu Glu His 
        195                 200                 205             


Leu Phe Phe Phe Arg Leu Ile Gly Asp Val Pro Ile Asp Thr Phe Leu 
    210                 215                 220                 


Met Glu Met Leu Glu Ser Pro Ser Asp Ser Ser Gly Gly Gly Ser Ala 
225                 230                 235                 240 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                245                 250                 255     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            260                 265                 270         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        275                 280                 285             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    290                 295                 300                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
305                 310                 315                 320 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                325                 330                 335     


His Met Gln Ala Leu Pro Pro Arg Arg Ala Glu Gly Arg Gly Ser Leu 
            340                 345                 350         


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Thr Asp 
        355                 360                 365             


Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr Gly 
    370                 375                 380                 


Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
385                 390                 395                 400 


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
                405                 410                 415     


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
            420                 425                 430         


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
        435                 440                 445             


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
    450                 455                 460                 


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
465                 470                 475                 480 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Lys Ala Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
        515                 520                 525             


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
    530                 535                 540                 


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
545                 550                 555                 560 


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
                565                 570                 575     


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
            580                 585                 590         


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
        595                 600                 605             


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
    610                 615                 620                 


Gln Gly Thr Ser Val Thr Val Ser Ser Asp Pro Ala Glu Pro Lys Ser 
625                 630                 635                 640 


Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                645                 650                 655     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            660                 665                 670         


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        675                 680                 685             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    690                 695                 700                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
705                 710                 715                 720 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                725                 730                 735     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            740                 745                 750         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        755                 760                 765             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    770                 775                 780                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
785                 790                 795                 800 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                805                 810                 815     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            820                 825                 830         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        835                 840                 845             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    850                 855                 860                 


Pro Gly Lys Lys Asp Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala 
865                 870                 875                 880 


Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys 
                885                 890                 895     


Arg His Arg Arg Arg Gln Ala Glu Arg Met Ala Gln Ile Lys Arg Val 
            900                 905                 910         


Val Ser Glu Lys Lys Thr Ala Gln Ala Pro His Arg Phe Gln Lys Thr 
        915                 920                 925             


Cys Ser Pro Ile Ser Gly Gly Gly Gly Ser Arg Pro Glu Cys Val Val 
    930                 935                 940                 


Pro Glu Thr Gln Cys Ala Met Lys Arg Lys Glu Lys Lys Ala Gln Lys 
945                 950                 955                 960 


Glu Lys Asp Lys Leu Pro Val Ser Thr Thr Thr Val Asp Asp His Met 
                965                 970                 975     


Pro Pro Ile Met Gln Cys Glu Pro Pro Pro Pro Glu Ala Ala Arg Ile 
            980                 985                 990         


His Glu Val Val Pro Arg Phe Leu  Ser Asp Lys Leu Leu  Glu Thr Asn 
        995                 1000                 1005             


Arg Gln  Lys Asn Ile Pro Gln  Leu Thr Ala Asn Gln  Gln Phe Leu 
    1010                 1015                 1020             


Ile Ala  Arg Leu Ile Trp Tyr  Gln Asp Gly Tyr Glu  Gln Pro Ser 
    1025                 1030                 1035             


Asp Glu  Asp Leu Lys Arg Ile  Thr Gln Thr Trp Gln  Gln Ala Asp 
    1040                 1045                 1050             


Asp Glu  Asn Glu Glu Ser Asp  Thr Pro Phe Arg Gln  Ile Thr Glu 
    1055                 1060                 1065             


Met Thr  Ile Leu Thr Val Gln  Leu Ile Val Glu Phe  Ala Lys Gly 
    1070                 1075                 1080             


Leu Pro  Gly Phe Ala Lys Ile  Ser Gln Pro Asp Gln  Ile Thr Leu 
    1085                 1090                 1095             


Leu Lys  Ala Cys Ser Ser Glu  Val Met Met Leu Arg  Val Ala Arg 
    1100                 1105                 1110             


Arg Tyr  Asp Ala Ala Ser Asp  Ser Ile Leu Phe Ala  Asn Asn Gln 
    1115                 1120                 1125             


Ala Tyr  Thr Arg Asp Asn Tyr  Arg Lys Ala Gly Met  Ala Glu Val 
    1130                 1135                 1140             


Ile Glu  Asp Leu Leu His Phe  Cys Arg Cys Met Tyr  Ser Met Ala 
    1145                 1150                 1155             


Leu Asp  Asn Ile His Tyr Ala  Leu Leu Thr Ala Val  Val Ile Phe 
    1160                 1165                 1170             


Ser Asp  Arg Pro Gly Leu Glu  Gln Pro Gln Leu Val  Glu Glu Ile 
    1175                 1180                 1185             


Gln Arg  Tyr Tyr Leu Asn Thr  Leu Arg Ile Tyr Ile  Leu Asn Gln 
    1190                 1195                 1200             


Leu Ser  Gly Ser Ala Arg Ser  Ser Val Ile Tyr Gly  Lys Ile Leu 
    1205                 1210                 1215             


Ser Ile  Leu Ser Glu Leu Arg  Thr Leu Gly Met Gln  Asn Ser Asn 
    1220                 1225                 1230             


Met Cys  Ile Ser Leu Lys Leu  Lys Asn Arg Lys Leu  Pro Pro Phe 
    1235                 1240                 1245             


Leu Glu  Glu Ile Trp Asp Val  Ala Asp Met Ser His  Thr Gln Pro 
    1250                 1255                 1260             


Pro Pro  Ile Leu Glu Ser Pro  Thr Asn Leu 
    1265                 1270             


<210>  24
<211>  919
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Simple inducible CAR

<400>  24

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly Gly Gly 
            100                 105                 110         


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
        115                 120                 125             


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
    130                 135                 140                 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
145                 150                 155                 160 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
                165                 170                 175     


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
            180                 185                 190         


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
        195                 200                 205             


Ala Leu His Met Gln Ala Leu Pro Pro Arg Arg Ala Glu Gly Arg Gly 
    210                 215                 220                 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu 
225                 230                 235                 240 


Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser 
                245                 250                 255     


Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
            260                 265                 270         


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
        275                 280                 285             


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
    290                 295                 300                 


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
                325                 330                 335     


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
            340                 345                 350         


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Lys Ala Gly 
        355                 360                 365             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
385                 390                 395                 400 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                405                 410                 415     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            420                 425                 430         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        435                 440                 445             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    450                 455                 460                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
465                 470                 475                 480 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                485                 490                 495     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Asp Pro Ala Glu Pro 
            500                 505                 510         


Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
        515                 520                 525             


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    530                 535                 540                 


Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
545                 550                 555                 560 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                565                 570                 575     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            580                 585                 590         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        595                 600                 605             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    610                 615                 620                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
625                 630                 635                 640 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                645                 650                 655     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            660                 665                 670         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        675                 680                 685             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    690                 695                 700                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
705                 710                 715                 720 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                725                 730                 735     


Leu Ser Pro Gly Lys Lys Asp Pro Met Ala Leu Ile Val Leu Gly Gly 
            740                 745                 750         


Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val 
        755                 760                 765             


Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ala Gln Ile Lys 
    770                 775                 780                 


Arg Val Val Ser Glu Lys Lys Thr Ala Gln Ala Pro His Arg Phe Gln 
785                 790                 795                 800 


Lys Thr Cys Ser Pro Ile Ser Gly Gly Gly Gly Ser Gly Val Gln Val 
                805                 810                 815     


Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln 
            820                 825                 830         


Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val 
        835                 840                 845             


Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys 
    850                 855                 860                 


Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val 
865                 870                 875                 880 


Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala 
                885                 890                 895     


Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp 
            900                 905                 910         


Val Glu Leu Leu Lys Leu Glu 
        915                 


<210>  25
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CID binding domain - EcR

<400>  25

Met Pro Val Asp Arg Ile Leu Glu Ala Glu Leu Ala Val Glu Gln Lys 
1               5                   10                  15      


Ser Asp Gln Gly Val Glu Gly Pro Gly Gly Thr Gly Gly Ser Gly Ser 
            20                  25                  30          


Ser Pro Asn Asp Pro Val Thr Asn Ile Cys Gln Ala Ala Asp Lys Gln 
        35                  40                  45              


Leu Phe Thr Leu Val Glu Trp Ala Lys Arg Ile Pro His Phe Ser Ser 
    50                  55                  60                  


Leu Pro Leu Asp Asp Gln Val Ile Leu Leu Arg Ala Gly Trp Asn Glu 
65                  70                  75                  80  


Leu Leu Ile Ala Ser Phe Ser His Arg Ser Ile Asp Val Arg Asp Gly 
                85                  90                  95      


Ile Leu Leu Ala Thr Gly Leu His Val His Arg Asn Ser Ala His Ser 
            100                 105                 110         


Ala Gly Val Gly Ala Ile Phe Asp Arg Val Leu Thr Glu Leu Val Ser 
        115                 120                 125             


Lys Met Arg Asp Met Arg Met Asp Lys Thr Glu Leu Gly Cys Leu Arg 
    130                 135                 140                 


Ala Ile Ile Leu Phe Asn Pro Glu Val Arg Gly Leu Lys Ser Ala Gln 
145                 150                 155                 160 


Glu Val Glu Leu Leu Arg Glu Lys Val Tyr Ala Ala Leu Glu Glu Tyr 
                165                 170                 175     


Thr Arg Thr Thr His Pro Asp Glu Pro Gly Arg Phe Ala Lys Leu Leu 
            180                 185                 190         


Leu Arg Leu Pro Ser Leu Arg Ser Ile Gly Leu Lys Cys Leu Glu His 
        195                 200                 205             


Leu Phe Phe Phe Arg Leu Ile Gly Asp Val Pro Ile Asp Thr Phe Leu 
    210                 215                 220                 


Met Glu Met Leu Glu Ser Pro Ser Asp Ser 
225                 230                 


<210>  26
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CID binding domain - RXR

<400>  26

Arg Pro Glu Cys Val Val Pro Glu Thr Gln Cys Ala Met Lys Arg Lys 
1               5                   10                  15      


Glu Lys Lys Ala Gln Lys Glu Lys Asp Lys Leu Pro Val Ser Thr Thr 
            20                  25                  30          


Thr Val Asp Asp His Met Pro Pro Ile Met Gln Cys Glu Pro Pro Pro 
        35                  40                  45              


Pro Glu Ala Ala Arg Ile His Glu Val Val Pro Arg Phe Leu Ser Asp 
    50                  55                  60                  


Lys Leu Leu Glu Thr Asn Arg Gln Lys Asn Ile Pro Gln Leu Thr Ala 
65                  70                  75                  80  


Asn Gln Gln Phe Leu Ile Ala Arg Leu Ile Trp Tyr Gln Asp Gly Tyr 
                85                  90                  95      


Glu Gln Pro Ser Asp Glu Asp Leu Lys Arg Ile Thr Gln Thr Trp Gln 
            100                 105                 110         


Gln Ala Asp Asp Glu Asn Glu Glu Ser Asp Thr Pro Phe Arg Gln Ile 
        115                 120                 125             


Thr Glu Met Thr Ile Leu Thr Val Gln Leu Ile Val Glu Phe Ala Lys 
    130                 135                 140                 


Gly Leu Pro Gly Phe Ala Lys Ile Ser Gln Pro Asp Gln Ile Thr Leu 
145                 150                 155                 160 


Leu Lys Ala Cys Ser Ser Glu Val Met Met Leu Arg Val Ala Arg Arg 
                165                 170                 175     


Tyr Asp Ala Ala Ser Asp Ser Ile Leu Phe Ala Asn Asn Gln Ala Tyr 
            180                 185                 190         


Thr Arg Asp Asn Tyr Arg Lys Ala Gly Met Ala Glu Val Ile Glu Asp 
        195                 200                 205             


Leu Leu His Phe Cys Arg Cys Met Tyr Ser Met Ala Leu Asp Asn Ile 
    210                 215                 220                 


His Tyr Ala Leu Leu Thr Ala Val Val Ile Phe Ser Asp Arg Pro Gly 
225                 230                 235                 240 


Leu Glu Gln Pro Gln Leu Val Glu Glu Ile Gln Arg Tyr Tyr Leu Asn 
                245                 250                 255     


Thr Leu Arg Ile Tyr Ile Leu Asn Gln Leu Ser Gly Ser Ala Arg Ser 
            260                 265                 270         


Ser Val Ile Tyr Gly Lys Ile Leu Ser Ile Leu Ser Glu Leu Arg Thr 
        275                 280                 285             


Leu Gly Met Gln Asn Ser Asn Met Cys Ile Ser Leu Lys Leu Lys Asn 
    290                 295                 300                 


Arg Lys Leu Pro Pro Phe Leu Glu Glu Ile Trp Asp Val Ala Asp Met 
305                 310                 315                 320 


Ser His Thr Gln Pro Pro Pro Ile Leu Glu Ser Pro Thr Asn Leu 
                325                 330                 335 


