                         SEQUENCE LISTING



<110>  Ramot at Tel-Aviv University Ltd.

       Mor Research Applications Ltd.

       SHALGI, Ruth

       CHUDERLAND, Dana

       BAR-JOSEPH, Hadas

       GOLDBERG, Keren

       BEN-AHARON, Irit

       STEMMER, Salomon M.

 

<120>  METHODS OF USING PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) FOR THE

        TREATMENT AND PREVENTION OF AGENT-INDUCED GONADAL OR UTERINE 

       TOXICITY



<130>  61743



<150>  US 61/972,325

<151>  2014-03-30



<160>  47    



<170>  PatentIn version 3.5



<210>  1

<211>  1542

<212>  DNA

<213>  Homo sapiens



<400>  1

ggtcgcttta agaaaggagt agctgtaatc tgaagcctgc tggacgctgg attagaaggc       60



agcaaaaaaa gctctgtgct ggctggagcc ccctcagtgt gcaggcttag agggactagg      120



ctgggtgtgg agctgcagcg tatccacagg ccccaggatg caggccctgg tgctactcct      180



ctgcattgga gccctcctcg ggcacagcag ctgccagaac cctgccagcc ccccggagga      240



gggctcccca gaccccgaca gcacaggggc gctggtggag gaggaggatc ctttcttcaa      300



agtccccgtg aacaagctgg cagcggctgt ctccaacttc ggctatgacc tgtaccgggt      360



gcgatccagc acgagcccca cgaccaacgt gctcctgtct cctctcagtg tggccacggc      420



cctctcggcc ctctcgctgg gagcggagca gcgaacagaa tccatcattc accgggctct      480



ctactatgac ttgatcagca gcccagacat ccatggtacc tataaggagc tccttgacac      540



ggtcactgcc ccccagaaga acctcaagag tgcctcccgg atcgtctttg agaagaagct      600



gcgcataaaa tccagctttg tggcacctct ggaaaagtca tatgggacca ggcccagagt      660



cctgacgggc aaccctcgct tggacctgca agagatcaac aactgggtgc aggcgcagat      720



gaaagggaag ctcgccaggt ccacaaagga aattcccgat gagatcagca ttctccttct      780



cggtgtggcg cacttcaagg ggcagtgggt aacaaagttt gactccagaa agacttccct      840



cgaggatttc tacttggatg aagagaggac cgtgagggtc cccatgatgt cggaccctaa      900



ggctgtttta cgctatggct tggattcaga tctcagctgc aagattgccc agctgccctt      960



gaccggaagc atgagtatca tcttcttcct gcccctgaaa gtgacccaga atttgacctt     1020



gatagaggag agcctcacct ccgagttcat tcatgacata gaccgagaac tgaagaccgt     1080



gcaggcggtc ctcactgtcc ccaagctgaa gctgagttat gaaggcgaag tcaccaagtc     1140



cctgcaggag atgaagctgc aatccttgtt tgattcacca gactttagca agatcacagg     1200



caaacccatc aagctgactc aggtggaaca ccgggctggc tttgagtgga acgaggatgg     1260



ggcgggaacc acccccagcc cagggctgca gcctgcccac ctcaccttcc cgctggacta     1320



tcaccttaac cagcctttca tcttcgtact gagggacaca gacacagggg cccttctctt     1380



cattggcaag attctggacc ccaggggccc ctaatatccc agtttaatat tccaataccc     1440



tagaagaaaa cccgagggac agcagattcc acaggacacg aaggctgccc ctgtaaggtt     1500



tcaatgcata caataaaaga gctttatccc taacttctgt ta                        1542





<210>  2

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  2

gtgaaggtcg gtgtgaacgg                                                   20





<210>  3

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  3

gtgatggcat ggactgtggt c                                                 21





<210>  4

<211>  18

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  4

tgtggcctca ttcctcct                                                     18





<210>  5

<211>  18

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  5

tgagaatggg gacactgt                                                     18





<210>  6

<211>  24

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  6

ctcatggact gattatggac agga                                              24





<210>  7

<211>  25

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  7

gcaggtcagc aaagaactta tagcc                                             25





<210>  8

<211>  18

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  8

ttcacccgga gcagtgat                                                     18





<210>  9

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  9

gcctccagaa ttgtgtttga g                                                 21





<210>  10

<211>  23

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  10

ccaagtctct gcaggacatg aag                                               23





<210>  11

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  11

ggtttgccag taatcttgct g                                                 21





<210>  12

<211>  21

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  12

aaccagttgt ggtgtcagga c                                                 21





<210>  13

<211>  23

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  13

ccgccatgtt tcttagagtg agg                                               23





<210>  14

<211>  20

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  14

ccaccgtgta tgccttctcc                                                   20





<210>  15

<211>  22

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  15

agagggacgc gacattctca at                                                22





<210>  16

<211>  22

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  16

tgtttcagac ggagagaacg tc                                                22





<210>  17

<211>  22

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  17

tgagaatggg gacactgtga tg                                                22





<210>  18

<211>  20

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  18

cctgggacct tcactaacca                                                   20





<210>  19

<211>  20

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  19

cagcatccac cacatcagac                                                   20





<210>  20

<211>  18

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  20

cttcagtgcc aacagcct                                                     18





<210>  21

<211>  19

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  21

gacagtctct ctcggccat                                                    19





<210>  22

<211>  22

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  22

gccaacctcc tgatgcttct tt                                                22





<210>  23

<211>  21

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  23

ttgtaccctc gaagcgtgtg a                                                 21





<210>  24

<211>  19

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  24

ggtgggcctt cctaacgag                                                    19





<210>  25

<211>  21

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  25

gaccacatca ggctcaatgc t                                                 21





<210>  26

<211>  1490

<212>  DNA

<213>  Homo sapiens



<400>  26

ggacgctgga ttagaaggca gcaaaaaaag atctgtgctg gctggagccc cctcagtgtg       60



caggcttaga gggactaggc tgggtgtgga gctgcagcgt atccacaggc cccaggatgc      120



aggccctggt gctactcctc tgcattggag ccctcctcgg gcacagcagc tgccagaacc      180



ctgccagccc cccggaggag ggctccccag accccgacag cacaggggcg ctggtggagg      240



aggaggatcc tttcttcaaa gtccccgtga acaagctggc agcggctgtc tccaacttcg      300



gctatgacct gtaccgggtg cgatccagca tgagccccac gaccaacgtg ctcctgtctc      360



ctctcagtgt ggccacggcc ctctcggccc tctcgctggg agcggacgag cgaacagaat      420



ccatcattca ccgggctctc tactatgact tgatcagcag cccagacatc catggtacct      480



ataaggagct ccttgacacg gtcactgccc cccagaagaa cctcaagagt gcctcccgga      540



tcgtctttga gaagaagctr cgcataaaat ccagctttgt ggcacctctg gaaaagtcat      600



atgggaccag gcccagagtc ctgacgggca accctcgctt ggacctgcaa gagatcaaca      660



actgggtgca ggcgcagatg aaagggaagc tcgccaggtc cacaaaggaa attcccgatg      720



agatcagcat tctccttctc ggtgtggcgc acttcaaggg gcagtgggta acaaagtttg      780



actccagaaa gacttccctc gaggatttct acttggatga agagaggacc gtgagggtcc      840



ccatgatgtc ggaccctaag gctgttttac gctatggctt ggattcagat ctcagctgca      900



agattgccca gctgcccttg accggaagca tgagtatcat cttcttcctg cccctgaaag      960



tgacccagaa tttgaccttg atagaggaga gcctcacctc cgagttcatt catgacatag     1020



accgagaact gaagaccgtg caggcggtcc tcactgtccc caagctgaag ctgagttacg     1080



aaggcgaagt caccaagtcc ctgcaggaga tgaagctgca atccttgttt gattcaccag     1140



actttagcaa gatcacaggc aaacccatca agctgactca ggtggaacac cgggctggct     1200



ttgagtggaa cgaggatggg gcgggaacca cccccagccc agggctgcag cctgcccacc     1260



tcaccttccc gctggactat caccttaacc agcctttcat cttcgtactg agggacacag     1320



acacaggggc ccttctcttc attggcaaga ttctggaccc caggggcccc taatatccca     1380



gtttaatatt ccaataccct agaagaaaac ccgagggaca gcagattcca caggacacga     1440



aggctgcccc tgtaaggttt caatgcatac aataaaagag ctttatccct                1490





<210>  27

<211>  418

<212>  PRT

<213>  Homo sapiens



<400>  27



Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 

1               5                   10                  15      





Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp 

            20                  25                  30          





Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys 

        35                  40                  45              





Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp 

    50                  55                  60                  





Leu Tyr Arg Val Arg Ser Ser Thr Ser Pro Thr Thr Asn Val Leu Leu 

65                  70                  75                  80  





Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala 

                85                  90                  95      





Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu 

            100                 105                 110         





Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr 

        115                 120                 125             





Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe 

    130                 135                 140                 





Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys 

145                 150                 155                 160 





Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp 

                165                 170                 175     





Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu 

            180                 185                 190         





Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu 

        195                 200                 205             





Gly Val Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg 

    210                 215                 220                 





Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg 

225                 230                 235                 240 





Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp 

                245                 250                 255     





Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met 

            260                 265                 270         





Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu 

        275                 280                 285             





Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu 

    290                 295                 300                 





Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser 

305                 310                 315                 320 





Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser 

                325                 330                 335     





Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys 

            340                 345                 350         





Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly 

        355                 360                 365             





Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe 

    370                 375                 380                 





Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp 

385                 390                 395                 400 





Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg 

                405                 410                 415     





Gly Pro 

        





<210>  28

<211>  3677

<212>  DNA

<213>  Homo sapiens



<400>  28

tcgcggaggc ttggggcagc cgggtagctc ggaggtcgtg gcgctggggg ctagcaccag       60



cgctctgtcg ggaggcgcag cggttaggtg gaccggtcag cggactcacc ggccagggcg      120



ctcggtgctg gaatttgata ttcattgatc cgggttttat ccctcttctt ttttcttaaa      180



catttttttt taaaactgta ttgtttctcg ttttaattta tttttgcttg ccattcccca      240



cttgaatcgg gccgacggct tggggagatt gctctacttc cccaaatcac tgtggatttt      300



ggaaaccagc agaaagagga aagaggtagc aagagctcca gagagaagtc gaggaagaga      360



gagacggggt cagagagagc gcgcgggcgt gcgagcagcg aaagcgacag gggcaaagtg      420



agtgacctgc ttttgggggt gaccgccgga gcgcggcgtg agccctcccc cttgggatcc      480



cgcagctgac cagtcgcgct gacggacaga cagacagaca ccgcccccag ccccagctac      540



cacctcctcc ccggccggcg gcggacagtg gacgcggcgg cgagccgcgg gcaggggccg      600



gagcccgcgc ccggaggcgg ggtggagggg gtcggggctc gcggcgtcgc actgaaactt      660



ttcgtccaac ttctgggctg ttctcgcttc ggaggagccg tggtccgcgc gggggaagcc      720



gagccgagcg gagccgcgag aagtgctagc tcgggccggg aggagccgca gccggaggag      780



ggggaggagg aagaagagaa ggaagaggag agggggccgc agtggcgact cggcgctcgg      840



aagccgggct catggacggg tgaggcggcg gtgtgcgcag acagtgctcc agccgcgcgc      900



gctccccagg ccctggcccg ggcctcgggc cggggaggaa gagtagctcg ccgaggcgcc      960



gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc     1020



ggtcgggcct ccgaaaccat gaactttctg ctgtcttggg tgcattggag ccttgccttg     1080



ctgctctacc tccaccatgc caagtggtcc caggctgcac ccatggcaga aggaggaggg     1140



cagaatcatc acgaagtggt gaagttcatg gatgtctatc agcgcagcta ctgccatcca     1200



atcgagaccc tggtggacat cttccaggag taccctgatg agatcgagta catcttcaag     1260



ccatcctgtg tgcccctgat gcgatgcggg ggctgctgca atgacgaggg cctggagtgt     1320



gtgcccactg aggagtccaa catcaccatg cagattatgc ggatcaaacc tcaccaaggc     1380



cagcacatag gagagatgag cttcctacag cacaacaaat gtgaatgcag accaaagaaa     1440



gatagagcaa gacaagaaaa aaaatcagtt cgaggaaagg gaaaggggca aaaacgaaag     1500



cgcaagaaat cccggtataa gtcctggagc gtgtacgttg gtgcccgctg ctgtctaatg     1560



ccctggagcc tccctggccc ccatccctgt gggccttgct cagagcggag aaagcatttg     1620



tttgtacaag atccgcagac gtgtaaatgt tcctgcaaaa acacagactc gcgttgcaag     1680



gcgaggcagc ttgagttaaa cgaacgtact tgcagatgtg acaagccgag gcggtgagcc     1740



gggcaggagg aaggagcctc cctcagggtt tcgggaacca gatctctcac caggaaagac     1800



tgatacagaa cgatcgatac agaaaccacg ctgccgccac cacaccatca ccatcgacag     1860



aacagtcctt aatccagaaa cctgaaatga aggaagagga gactctgcgc agagcacttt     1920



gggtccggag ggcgagactc cggcggaagc attcccgggc gggtgaccca gcacggtccc     1980



tcttggaatt ggattcgcca ttttattttt cttgctgcta aatcaccgag cccggaagat     2040



tagagagttt tatttctggg attcctgtag acacacccac ccacatacat acatttatat     2100



atatatatat tatatatata taaaaataaa tatctctatt ttatatatat aaaatatata     2160



tattcttttt ttaaattaac agtgctaatg ttattggtgt cttcactgga tgtatttgac     2220



tgctgtggac ttgagttggg aggggaatgt tcccactcag atcctgacag ggaagaggag     2280



gagatgagag actctggcat gatctttttt ttgtcccact tggtggggcc agggtcctct     2340



cccctgccca ggaatgtgca aggccagggc atgggggcaa atatgaccca gttttgggaa     2400



caccgacaaa cccagccctg gcgctgagcc tctctacccc aggtcagacg gacagaaaga     2460



cagatcacag gtacagggat gaggacaccg gctctgacca ggagtttggg gagcttcagg     2520



acattgctgt gctttgggga ttccctccac atgctgcacg cgcatctcgc ccccaggggc     2580



actgcctgga agattcagga gcctgggcgg ccttcgctta ctctcacctg cttctgagtt     2640



gcccaggaga ccactggcag atgtcccggc gaagagaaga gacacattgt tggaagaagc     2700



agcccatgac agctcccctt cctgggactc gccctcatcc tcttcctgct ccccttcctg     2760



gggtgcagcc taaaaggacc tatgtcctca caccattgaa accactagtt ctgtcccccc     2820



aggagacctg gttgtgtgtg tgtgagtggt tgaccttcct ccatcccctg gtccttccct     2880



tcccttcccg aggcacagag agacagggca ggatccacgt gcccattgtg gaggcagaga     2940



aaagagaaag tgttttatat acggtactta tttaatatcc ctttttaatt agaaattaaa     3000



acagttaatt taattaaaga gtagggtttt ttttcagtat tcttggttaa tatttaattt     3060



caactattta tgagatgtat cttttgctct ctcttgctct cttatttgta ccggtttttg     3120



tatataaaat tcatgtttcc aatctctctc tccctgatcg gtgacagtca ctagcttatc     3180



ttgaacagat atttaatttt gctaacactc agctctgccc tccccgatcc cctggctccc     3240



cagcacacat tcctttgaaa taaggtttca atatacatct acatactata tatatatttg     3300



gcaacttgta tttgtgtgta tatatatata tatatgttta tgtatatatg tgattctgat     3360



aaaatagaca ttgctattct gttttttata tgtaaaaaca aaacaagaaa aaatagagaa     3420



ttctacatac taaatctctc tcctttttta attttaatat ttgttatcat ttatttattg     3480



gtgctactgt ttatccgtaa taattgtggg gaaaagatat taacatcacg tctttgtctc     3540



tagtgcagtt tttcgagata ttccgtagta catatttatt tttaaacaac gacaaagaaa     3600



tacagatata tcttaaaaaa aaaaaagcat tttgtattaa agaatttaat tctgatctca     3660



aaaaaaaaaa aaaaaaa                                                    3677





<210>  29

<211>  412

<212>  PRT

<213>  Homo sapiens



<400>  29



Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 

1               5                   10                  15      





Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 

            20                  25                  30          





Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 

        35                  40                  45              





Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 

    50                  55                  60                  





Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 

65                  70                  75                  80  





Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 

                85                  90                  95      





Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 

            100                 105                 110         





Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 

        115                 120                 125             





Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 

    130                 135                 140                 





Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 

145                 150                 155                 160 





His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 

                165                 170                 175     





Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 

            180                 185                 190         





Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 

        195                 200                 205             





Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 

    210                 215                 220                 





Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 

225                 230                 235                 240 





Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 

                245                 250                 255     





Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 

            260                 265                 270         





Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 

        275                 280                 285             





Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 

    290                 295                 300                 





His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 

305                 310                 315                 320 





Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 

                325                 330                 335     





Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys 

            340                 345                 350         





Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser 

        355                 360                 365             





Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys 

    370                 375                 380                 





Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu 

385                 390                 395                 400 





Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 

                405                 410         





<210>  30

<211>  389

<212>  PRT

<213>  Homo sapiens



<400>  30



Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 

1               5                   10                  15      





Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 

            20                  25                  30          





Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 

        35                  40                  45              





Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 

    50                  55                  60                  





Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 

65                  70                  75                  80  





Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 

                85                  90                  95      





Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 

            100                 105                 110         





Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 

        115                 120                 125             





Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 

    130                 135                 140                 





Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 

145                 150                 155                 160 





His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 

                165                 170                 175     





Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 

            180                 185                 190         





Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 

        195                 200                 205             





Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 

    210                 215                 220                 





Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 

225                 230                 235                 240 





Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 

                245                 250                 255     





Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 

            260                 265                 270         





Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 

        275                 280                 285             





Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 

    290                 295                 300                 





His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 

305                 310                 315                 320 





Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 

                325                 330                 335     





Lys Ser Arg Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe 

            340                 345                 350         





Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser 

        355                 360                 365             





Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys 

    370                 375                 380                 





Asp Lys Pro Arg Arg 

385                 





<210>  31

<211>  371

<212>  PRT

<213>  Homo sapiens



<400>  31



Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 

1               5                   10                  15      





Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 

            20                  25                  30          





Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 

        35                  40                  45              





Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 

    50                  55                  60                  





Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 

65                  70                  75                  80  





Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 

                85                  90                  95      





Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 

            100                 105                 110         





Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 

        115                 120                 125             





Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 

    130                 135                 140                 





Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 

145                 150                 155                 160 





His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 

                165                 170                 175     





Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 

            180                 185                 190         





Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 

        195                 200                 205             





Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 

    210                 215                 220                 





Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 

225                 230                 235                 240 





Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 

                245                 250                 255     





Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 

            260                 265                 270         





Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 

        275                 280                 285             





Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 

    290                 295                 300                 





His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 

305                 310                 315                 320 





Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 

                325                 330                 335     





Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 

            340                 345                 350         





Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys 

        355                 360                 365             





Pro Arg Arg 

    370     





<210>  32

<211>  354

<212>  PRT

<213>  Homo sapiens



<400>  32



Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 

1               5                   10                  15      





Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 

            20                  25                  30          





Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 

        35                  40                  45              





Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 

    50                  55                  60                  





Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 

65                  70                  75                  80  





Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 

                85                  90                  95      





Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 

            100                 105                 110         





Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 

        115                 120                 125             





Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 

    130                 135                 140                 





Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 

145                 150                 155                 160 





His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 

                165                 170                 175     





Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 

            180                 185                 190         





Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 

        195                 200                 205             





Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 

    210                 215                 220                 





Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 

225                 230                 235                 240 





Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 

                245                 250                 255     





Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 

            260                 265                 270         





Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 

        275                 280                 285             





Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 

    290                 295                 300                 





His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 

305                 310                 315                 320 





Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 

                325                 330                 335     





Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 

            340                 345                 350         





Lys Met 

        





<210>  33

<211>  327

<212>  PRT

<213>  Homo sapiens



<400>  33



Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 

1               5                   10                  15      





Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 

            20                  25                  30          





Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 

        35                  40                  45              





Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 

    50                  55                  60                  





Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 

65                  70                  75                  80  





Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 

                85                  90                  95      





Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 

            100                 105                 110         





Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 

        115                 120                 125             





Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 

    130                 135                 140                 





Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 

145                 150                 155                 160 





His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 

                165                 170                 175     





Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 

            180                 185                 190         





Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 

        195                 200                 205             





Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 

    210                 215                 220                 





Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 

225                 230                 235                 240 





Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 

                245                 250                 255     





Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 

            260                 265                 270         





Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 

        275                 280                 285             





Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 

    290                 295                 300                 





His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 

305                 310                 315                 320 





Lys Cys Asp Lys Pro Arg Arg 

                325         





<210>  34

<211>  371

<212>  PRT

<213>  Homo sapiens



<400>  34



Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 

1               5                   10                  15      





Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 

            20                  25                  30          





Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 

        35                  40                  45              





Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 

    50                  55                  60                  





Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 

65                  70                  75                  80  





Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 

                85                  90                  95      





Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 

            100                 105                 110         





Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 

        115                 120                 125             





Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 

    130                 135                 140                 





Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 

145                 150                 155                 160 





His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 

                165                 170                 175     





Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 

            180                 185                 190         





Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 

        195                 200                 205             





Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 

    210                 215                 220                 





Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 

225                 230                 235                 240 





Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 

                245                 250                 255     





Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 

            260                 265                 270         





Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 

        275                 280                 285             





Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 

    290                 295                 300                 





His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 

305                 310                 315                 320 





Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 

                325                 330                 335     





Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 

            340                 345                 350         





Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Ser Leu Thr 

        355                 360                 365             





Arg Lys Asp 

    370     





<210>  35

<211>  317

<212>  PRT

<213>  Homo sapiens



<400>  35



Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 

1               5                   10                  15      





Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 

            20                  25                  30          





Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 

        35                  40                  45              





Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 

    50                  55                  60                  





Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 

65                  70                  75                  80  





Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 

                85                  90                  95      





Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 

            100                 105                 110         





Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 

        115                 120                 125             





Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 

    130                 135                 140                 





Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 

145                 150                 155                 160 





His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 

                165                 170                 175     





Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 

            180                 185                 190         





Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 

        195                 200                 205             





Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 

    210                 215                 220                 





Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 

225                 230                 235                 240 





Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 

                245                 250                 255     





Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 

            260                 265                 270         





Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 

        275                 280                 285             





Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 

    290                 295                 300                 





His Asn Lys Cys Glu Cys Arg Cys Asp Lys Pro Arg Arg 

305                 310                 315         





<210>  36

<211>  232

<212>  PRT

<213>  Homo sapiens



<400>  36



Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 

1               5                   10                  15      





Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 

            20                  25                  30          





Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 

        35                  40                  45              





Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 

    50                  55                  60                  





Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 

65                  70                  75                  80  





Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 

                85                  90                  95      





Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 

            100                 105                 110         





Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 

        115                 120                 125             





Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 

    130                 135                 140                 





Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 

145                 150                 155                 160 





Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys Leu Met Pro Trp 

                165                 170                 175     





Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys 

            180                 185                 190         





His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn 

        195                 200                 205             





Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr 

    210                 215                 220                 





Cys Arg Cys Asp Lys Pro Arg Arg 

225                 230         





<210>  37

<211>  215

<212>  PRT

<213>  Homo sapiens



<400>  37



Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 

1               5                   10                  15      





Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 

            20                  25                  30          





Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 

        35                  40                  45              





Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 

    50                  55                  60                  





Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 

65                  70                  75                  80  





Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 

                85                  90                  95      





Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 

            100                 105                 110         





Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 

        115                 120                 125             





Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 

    130                 135                 140                 





Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 

145                 150                 155                 160 





Lys Ser Trp Ser Val Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His 

                165                 170                 175     





Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr 

            180                 185                 190         





Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys 

        195                 200                 205             





Arg Cys Asp Lys Pro Arg Arg 

    210                 215 





<210>  38

<211>  209

<212>  PRT

<213>  Homo sapiens



<400>  38



Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 

1               5                   10                  15      





Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 

            20                  25                  30          





Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 

        35                  40                  45              





Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 

    50                  55                  60                  





Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 

65                  70                  75                  80  





Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 

                85                  90                  95      





Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 

            100                 105                 110         





Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 

        115                 120                 125             





Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 

    130                 135                 140                 





Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Pro 

145                 150                 155                 160 





Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro 

                165                 170                 175     





Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala 

            180                 185                 190         





Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg 

        195                 200                 205             





Arg 

    





<210>  39

<211>  191

<212>  PRT

<213>  Homo sapiens



<400>  39



Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 

1               5                   10                  15      





Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 

            20                  25                  30          





Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 

        35                  40                  45              





Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 

    50                  55                  60                  





Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 

65                  70                  75                  80  





Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 

                85                  90                  95      





Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 

            100                 105                 110         





Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 

        115                 120                 125             





Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 

    130                 135                 140                 





Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 

145                 150                 155                 160 





Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 

                165                 170                 175     





Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 

            180                 185                 190     





<210>  40

<211>  174

<212>  PRT

<213>  Homo sapiens



<400>  40



Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 

1               5                   10                  15      





Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 

            20                  25                  30          





Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 

        35                  40                  45              





Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 

    50                  55                  60                  





Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 

65                  70                  75                  80  





Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 

                85                  90                  95      





Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 

            100                 105                 110         





Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 

        115                 120                 125             





Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 

    130                 135                 140                 





Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 

145                 150                 155                 160 





Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Met 

                165                 170                 





<210>  41

<211>  147

<212>  PRT

<213>  Homo sapiens



<400>  41



Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 

1               5                   10                  15      





Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 

            20                  25                  30          





Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 

        35                  40                  45              





Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 

    50                  55                  60                  





Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 

65                  70                  75                  80  





Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 

                85                  90                  95      





Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 

            100                 105                 110         





Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 

        115                 120                 125             





Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Cys Asp Lys 

    130                 135                 140                 





Pro Arg Arg 

145         





<210>  42

<211>  191

<212>  PRT

<213>  Homo sapiens



<400>  42



Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 

1               5                   10                  15      





Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 

            20                  25                  30          





Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 

        35                  40                  45              





Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 

    50                  55                  60                  





Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 

65                  70                  75                  80  





Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 

                85                  90                  95      





Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 

            100                 105                 110         





Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 

        115                 120                 125             





Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 

    130                 135                 140                 





Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 

145                 150                 155                 160 





Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 

                165                 170                 175     





Leu Glu Leu Asn Glu Arg Thr Cys Arg Ser Leu Thr Arg Lys Asp 

            180                 185                 190     





<210>  43

<211>  137

<212>  PRT

<213>  Homo sapiens



<400>  43



Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 

1               5                   10                  15      





Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 

            20                  25                  30          





Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 

        35                  40                  45              





Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 

    50                  55                  60                  





Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 

65                  70                  75                  80  





Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 

                85                  90                  95      





Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 

            100                 105                 110         





Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 

        115                 120                 125             





Glu Cys Arg Cys Asp Lys Pro Arg Arg 

    130                 135         





<210>  44

<211>  171

<212>  PRT

<213>  Homo sapiens



<400>  44



Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 

1               5                   10                  15      





Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 

            20                  25                  30          





Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 

        35                  40                  45              





Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 

    50                  55                  60                  





Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 

65                  70                  75                  80  





Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 

                85                  90                  95      





Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 

            100                 105                 110         





Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 

        115                 120                 125             





Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 

    130                 135                 140                 





Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 

145                 150                 155                 160 





Lys Ser Trp Ser Val Cys Asp Lys Pro Arg Arg 

                165                 170     





<210>  45

<211>  351

<212>  PRT

<213>  Homo sapiens



<400>  45



Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 

1               5                   10                  15      





Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 

            20                  25                  30          





Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 

        35                  40                  45              





Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 

    50                  55                  60                  





Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 

65                  70                  75                  80  





Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 

                85                  90                  95      





Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 

            100                 105                 110         





Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 

        115                 120                 125             





Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 

    130                 135                 140                 





Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 

145                 150                 155                 160 





His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 

                165                 170                 175     





Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 

            180                 185                 190         





Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 

        195                 200                 205             





Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 

    210                 215                 220                 





Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 

225                 230                 235                 240 





Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 

                245                 250                 255     





Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 

            260                 265                 270         





Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 

        275                 280                 285             





Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 

    290                 295                 300                 





His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 

305                 310                 315                 320 





Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 

                325                 330                 335     





Lys Ser Arg Tyr Lys Ser Trp Ser Val Cys Asp Lys Pro Arg Arg 

            340                 345                 350     





<210>  46

<211>  163

<212>  PRT

<213>  Homo sapiens



<400>  46



Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 

1               5                   10                  15      





Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 

            20                  25                  30          





Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 

        35                  40                  45              





Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 

    50                  55                  60                  





Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 

65                  70                  75                  80  





Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 

                85                  90                  95      





His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 

            100                 105                 110         





Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 

        115                 120                 125             





Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 

    130                 135                 140                 





Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys 

145                 150                 155                 160 





Pro Arg Arg 

            





<210>  47

<211>  395

<212>  PRT

<213>  Homo sapiens



<400>  47



Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 

1               5                   10                  15      





Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 

            20                  25                  30          





Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 

        35                  40                  45              





Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 

    50                  55                  60                  





Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 

65                  70                  75                  80  





Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 

                85                  90                  95      





Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 

            100                 105                 110         





Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 

        115                 120                 125             





Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 

    130                 135                 140                 





Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 

145                 150                 155                 160 





His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 

                165                 170                 175     





Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 

            180                 185                 190         





Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 

        195                 200                 205             





Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 

    210                 215                 220                 





Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 

225                 230                 235                 240 





Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 

                245                 250                 255     





Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 

            260                 265                 270         





Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 

        275                 280                 285             





Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 

    290                 295                 300                 





His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 

305                 310                 315                 320 





Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 

                325                 330                 335     





Lys Ser Arg Tyr Lys Ser Trp Ser Val Pro Cys Gly Pro Cys Ser Glu 

            340                 345                 350         





Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser 

        355                 360                 365             





Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn 

    370                 375                 380                 





Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 

385                 390                 395 





