                         SEQUENCE LISTING

<110>  University of North Carolina at Chapel Hill
       Parise, Leslie
       Leisner, Tina
       Black, Justin
 
<120>  CIB1 Manipulation to Kill Cancer Cells

<130>  5470-697WO

<150>  US 61/976,519
<151>  2014-04-08

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  1
ttggacaggc gactgcccg                                                    19


<210>  2
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  2
tactcggcca gcagctcct                                                    19


<210>  3
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  3
aagtcctggt actcggcca                                                    19


<210>  4
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  4
taggaggatc tcctgcttc                                                    19


<210>  5
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  5
gaatctgctc gaagggcact t                                                 21


<210>  6
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  6
aaggctgaga atctgctcg                                                    19


<210>  7
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  7
gagctctgga aggctgaga                                                    19


<210>  8
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  8
ttggccttga gctctggaa                                                    19


<210>  9
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  9
atgtggagaa gaccctgca                                                    19


<210>  10
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  10
aagtcctcaa agctaaggct g                                                 21


<210>  11
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  11
acacactgag gagatccag                                                    19


<210>  12
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  12
tgtgtcactg aacacactg                                                    19


<210>  13
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  13
ttgatgtctg gcgtggctg                                                    19


<210>  14
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  14
aaagtcaaag atgcggaag                                                    19


<210>  15
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  15
ccgtcatcat caaagttaa                                                    19


<210>  16
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  16
tgttcaaggt tccgtcatc                                                    19


<210>  17
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  17
tctctgttca aggttccgt                                                    19


<210>  18
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  18
tgaggcagtt caccagccg                                                    19


<210>  19
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  19
taagccgtgt gtcctcgcc                                                    19


<210>  20
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  20
atctcagacg cactaagcc                                                    19


<210>  21
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  21
aactcagaga ggttgatgg                                                    19


<210>  22
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  22
taaaggagct ggcaaagtc                                                    19


<210>  23
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  23
tcttaaagga gctggcaaa                                                    19


<210>  24
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  24
tcacaggaca atcttaaag                                                    19


<210>  25
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 KD shRNA sequence

<400>  25
gctgtcacag gacaatctt                                                    19


<210>  26
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  26
cgggcagtcg cctgtccaa                                                    19


<210>  27
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  27
aggagctgct ggccgagta                                                    19


<210>  28
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  28
tggccgagta ccaggactt                                                    19


<210>  29
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  29
gaagcaggag atcctccta                                                    19


<210>  30
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  30
aagtgccctt cgagcagatt c                                                 21


<210>  31
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  31
cgagcagatt ctcagcctt                                                    19


<210>  32
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  32
tctcagcctt ccagagctc                                                    19


<210>  33
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  33
ttccagagct caaggccaa                                                    19


<210>  34
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  34
tgcagggtct tctccacat                                                    19


<210>  35
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  35
cagccttagc tttgaggact t                                                 21


<210>  36
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  36
ctggatctcc tcagtgtgt                                                    19


<210>  37
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  37
cagtgtgttc agtgacaca                                                    19


<210>  38
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  38
cagccacgcc agacatcaa                                                    19


<210>  39
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  39
cttccgcatc tttgacttt                                                    19


<210>  40
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  40
ttaactttga tgatgacgg                                                    19


<210>  41
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  41
gatgacggaa ccttgaaca                                                    19


<210>  42
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  42
acggaacctt gaacagaga                                                    19


<210>  43
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  43
cggctggtga actgcctca                                                    19


<210>  44
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  44
ggcgaggaca cacggctta                                                    19


<210>  45
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  45
ggcttagtgc gtctgagat                                                    19


<210>  46
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  46
ccatcaacct ctctgagtt                                                    19


<210>  47
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  47
gactttgcca gctccttta                                                    19


<210>  48
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  48
tttgccagct cctttaaga                                                    19


<210>  49
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  49
ctttaagatt gtcctgtga                                                    19


<210>  50
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  CIB1 target DNA/mRNA sequence

<400>  50
aagattgtcc tgtgacagc                                                    19


<210>  51
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  51
cgggcagtcg cctgtccaat tggatccaat tggacaggcg actgcccg                    48


<210>  52
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  52
aggagctgct ggccgagtat tggatccaat actcggccag cagctcct                    48


<210>  53
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  53
tggccgagta ccaggacttt tggatccaaa agtcctggta ctcggcca                    48


<210>  54
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  54
gaagcaggag atcctcctat tggatccaat aggaggatct cctgcttc                    48


<210>  55
<211>  52
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  55
aagtgccctt cgagcagatt cttggatcca agaatctgct cgaagggcac tt               52


<210>  56
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  56
cgagcagatt ctcagccttt tggatccaaa aggctgagaa tctgctcg                    48


<210>  57
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  57
tctcagcctt ccagagctct tggatccaag agctctggaa ggctgaga                    48


<210>  58
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  58
ttccagagct caaggccaat tggatccaat tggccttgag ctctggaa                    48


<210>  59
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  59
tgcagggtct tctccacatt tggatccaaa tgtggagaag accctgca                    48


<210>  60
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  60
cagccttagc tttgaggact tctcgagaag tcctcaaagc taaggctg                    48


<210>  61
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  61
ctggatctcc tcagtgtgtt tggatccaaa cacactgagg agatccag                    48


<210>  62
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  62
cagtgtgttc agtgacacat tggatccaat gtgtcactga acacactg                    48


<210>  63
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  63
cagccacgcc agacatcaat tggatccaat tgatgtctgg cgtggctg                    48


<210>  64
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  64
cttccgcatc tttgactttt tggatccaaa aagtcaaaga tgcggaag                    48


<210>  65
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  65
ttaactttga tgatgacggt tggatccaac cgtcatcatc aaagttaa                    48


<210>  66
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  66
gatgacggaa ccttgaacat tggatccaat gttcaaggtt ccgtcatc                    48


<210>  67
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  67
acggaacctt gaacagagat tggatccaat ctctgttcaa ggttccgt                    48


<210>  68
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  68
cggctggtga actgcctcat tggatccaat gaggcagttc accagccg                    48


<210>  69
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  69
ggcgaggaca cacggcttat tggatccaat aagccgtgtg tcctcgcc                    48


<210>  70
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  70
ggcttagtgc gtctgagatt tggatccaaa tctcagacgc actaagcc                    48


<210>  71
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  71
ccatcaacct ctctgagttt tggatccaaa actcagagag gttgatgg                    48


<210>  72
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  72
gactttgcca gctcctttat tggatccaat aaaggagctg gcaaagtc                    48


<210>  73
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  73
tttgccagct cctttaagat tggatccaat cttaaaggag ctggcaaa                    48


<210>  74
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  74
ctttaagatt gtcctgtgat tggatccaat cacaggacaa tcttaaag                    48


<210>  75
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Complete hairpin sequence

<400>  75
aagattgtcc tgtgacagct tggatccaag ctgtcacagg acaatctt                    48


<210>  76
<211>  995
<212>  DNA
<213>  Homo sapiens

<400>  76
ggctgggaac gcctggcagc ttttaggagg gggcgggccc gggggtggtg gccccaggag       60

cggttgccgc ggggaccggg cagtgacgcg gcccaagggc ggaagtgaga aagttgtctg      120

cgtctcgagg cgagttggcg gagctgtgcg cgcggcgggg cgatgggggg ctcgggcagt      180

cgcctgtcca aggagctgct ggccgagtac caggacttga cgttcctgac gaagcaggag      240

atcctcctag cccacaggcg gttttgtgag ctgcttcccc aggagcagcg gagcgtggag      300

tcgtcacttc gggcacaagt gcccttcgag cagattctca gccttccaga gctcaaggcc      360

aaccccttca aggagcgaat ctgcagggtc ttctccacat ccccagccaa agacagcctt      420

agctttgagg acttcctgga tctcctcagt gtgttcagtg acacagccac gccagacatc      480

aagtcccatt atgccttccg catctttgac tttgatgatg acggaacctt gaacagagaa      540

gacctgagcc ggctggtgaa ctgcctcacg ggagagggcg aggacacacg gcttagtgcg      600

tctgagatga agcagctcat cgacaacatc ctggaggagt ctgacattga cagggatgga      660

accatcaacc tctctgagtt ccagcacgtc atctcccgtt ctccagactt tgccagctcc      720

tttaagattg tcctgtgaca gcagccccag cgtgtgtcct ggcaccctgt ccaagaacct      780

ttctactgct gagctgtggc caaggtcaag cctgtgttgc cagtgcgggc caagctggcc      840

cagcctggag ctggcgctgt gcagcctcac cccgggcagg ggcggccctc gttgtcaggg      900

cctctcctca ctgctgttgt cattgctccg tttgtgtttg tactaatcag taataaaggt      960

ttagaagttt gaccctaaaa aaaaaaaaaa aaaaa                                 995


<210>  77
<211>  3402
<212>  DNA
<213>  Homo sapiens

<400>  77
atggggggct cgggcagtcg cctgtccaag gagctgctgg ccgagtacca ggtgcgcggg       60

acgcctggcc ctggggagct cgcgtgcggg cctcttctcg ggagcagggt ccgggagctg      120

gctgcggggc ggccgcggcc tcccagcggt ccgctaatcc ccgctctggc tttgccttcc      180

aggacttgac gttcctgacg aagcaggaga tcctcctgta agtgctgcct tgaaccctgc      240

ctccgacccc gggatcctct agagacagct tcgggggcgc tgtcccgagg gaggggcggg      300

ggctggcctg aggtctgcag aggagcggga gctggaggcc gggagaccta gcccgggctg      360

cgccctcctc ccggcacgcc ctccccgccc tcgcctgagg ccccagcgtg gcaccgcgga      420

gccaccttac agcctccagg aaaagttagg cgctctttga ccctgggctc cactagcttc      480

agcactgccg aacttcctgc cccagtccgg caggggccga ccttgcccag tggctaaacc      540

acagaagcct tggggagccc ggctccttct cccaacttta cctgaataat acagtaaccg      600

ttatcgcttt ctgagcactc accatgtgcc agggactgtg ctaaatggtt gcctgcgtta      660

cctaatttaa tctttaggag agaggtactg gacaatgaaa caggttcaga aaggtttggt      720

aactgcttaa gacaacactc tgagtaagta gatttgaact tgggctggaa gcccttttgc      780

cggatttatg caggccaggt tcctgtggca aagataagct catgggaagg aggtggaggc      840

cgaggaggac agttcagtgt ggttgctaaa aaggaggctt tgagggtaag agatccctgg      900

agtgaaggtg agaatgagat ttttggtttt gctcttttct ccgttttttt ttttttgaga      960

cagcgtctcg ctctgtcgcc caggctggag tgctggggca cgatcttggc tcactgcagg     1020

ctctgcctcc gggttcaagt gattctcctg cctccgggtt caagtgattc tcctgcctca     1080

gcctcctgag tagctgggat tataggcacc cgccaccatg cccggctaat ttttgtattt     1140

ttagtagaga aggggttcac catgttgctc agactggtct cagacgcctg acctccaaag     1200

ctccgcccgc cttggcctcc caaagtgctg ggattacagg tgtgagccac cgtgcctggc     1260

caattcttta gggccaactt ctggctcctt tcccaacttc ttcatccctt ggggatctct     1320

agaatcagtg ccaagcacat agtaaatgct cagtaaatac tcattgcaag aatagactcc     1380

taggctgtac tgccttgtga catgtccttt tgcttaccgt tgcctgatga ctcggaagtt     1440

ctgtgtacgt ggttttagct cctcacctgg ttgacaatga gcagcaggca aggagtggga     1500

atgaacacac agggagaccg atcgctgaga acaccgacag ttcccctctc tctaccagag     1560

cccacaggcg gttttgtgag ctgcttcccc aggagcagcg gagcgtggag tcgtcacttc     1620

gggcacaagt gcccttcgag cagattctca gccttccaga gctcaaggtg caagcgctcc     1680

cctcctttga cacctctccc accactccct ccctgctaga ccccctaact ccatctgcca     1740

ctagctttgg gatcatgggg tcactggtcc ccactctggt catttttctg cttagttctg     1800

attttctagg ggcaaggact ttaccaaaat cacctggcag aattatctag aatggtgctt     1860

ttcaaatggg gattctagaa cataatcttg gaagttcaaa gaagttttgt cccttaagag     1920

gagttgaggt acctcattag agtttgagga accgtgttct agaggctgat tgccactccg     1980

taaggctgct gcaaaatttc tgtgcaaagg gcctggcccg gtgcctgtaa cacaatagct     2040

gttcaagtaa atatttgtgt tttaaaataa ccagcccatc tcgttccctt tgtttaggat     2100

gacttcttct tccctctctg cccacactta cgttgtatgt gacctgcctt tgggttaaac     2160

acttgactcc caggaagcca tctcagtccc ttccccagct gggtcagttt gctttcctgt     2220

gcccccactg ccctccatgt tggccccaaa gcactgactg ttcaccccca cgaggctgag     2280

ctcgctggtg ctggtcctgt gacctgctct ctcaagtttc tggtaggctt taatgagcgt     2340

gtgacctggg ccacgtcctg tggcgtttgt tctcctaggc caaccccttc aaggagcgaa     2400

tctgcagggt cttctccaca tccccagcca aagacagcct tagctttgag gacttcctgg     2460

atctcctcag tgtgttcagt gacacagcca cgccagacat caagtcccat tatgccttcc     2520

gcatctttgg tgagaaccag gagcagcccg gcaggacacc accccttccc acgtgggctt     2580

tgtggtggcc ctgcttggga aatgggcgcc gtttggggaa cctcagagcc cctcccaacc     2640

gtgtcttttg gcttcctgtg tctgctctct agactttgat gatgacggaa ccttgaacag     2700

agaagacctg agccggctgg tgaactgcct cacgggagag ggcgaggaca cacggcttag     2760

tgcgtctgag atgaagcagc tcatcgacaa cgtgagcagc tgagcaggcc tgggagcggg     2820

agggagcagt tggggctctg gcctgaaact ctccctttcc cagatcctgg aggagtctga     2880

cattgacagg gatggaacca tcaacctctc tgagttccag cacgtcatct cccgttctcc     2940

agactttgcc aggtatgaca gtggtccccc ttcattctgg gtacctgcag gttccgacct     3000

gctgcctctg ggcctagggc atggctacag gaggtggtgc cagggtgaga gaaagcccca     3060

gtccccacac acagggccgg ctaagctggc agtctcgccc cgggcagggg cagccctcct     3120

tgtcaagacc tctccccttc ccactgccat tgtcattgct ctgtgtttgt actcattagt     3180

aataaaggtt tagaagctct gacccagtgt gtgggtccag aaagctccct ctggatgtct     3240

cggggagttc ttgcagaggg ggctgacaca cggaacatag cccgttccaa agaagggtct     3300

aaagggagaa gggggcaagt tcgggtttag tccctgccct cctcttccag cagaaaaccc     3360

accgcttttc tcttgttcag ctcctttaag attgtcctgt ga                        3402


<210>  78
<211>  580
<212>  DNA
<213>  Homo sapiens

<400>  78
atggggggct cgggcagtcg cctgtccaag gagctgctgg ccgagtacca ggacttgacg       60

ttcctgacga agcaggagat cctcctagcc cacaggcggt tttgtgagct gcttccccag      120

gagcagcgga gcgtggagtc gtcacttcgg gcacaagtgc ccttcgagca gattctcagc      180

cttccagagc tcaaggccaa ccccttcaag gagcgaatct gcagggtctt ctccacatcc      240

ccagccaaag acagccttag ctttgaggac ttcctggatc tcctcagtgt gttcagtgac      300

acagccacgc cagacatcaa gtcccattat gccttccgca tctttgactt tgatgatgac      360

ggaaccttga acagagaaga cctgagccgg ctggtgaact gcctcacggg agagggcgag      420

gacacacggc ttagtgcgtc tgagatgaag cagctcatcg acaacatcct ggaggagtct      480

gacattgaca gggatggaac catcaacctc tctgagttcc agcacgtcat ctcccgttct      540

ccagactttg ccagctcctt taagattgtc ctgtgacagc                            580


