                         SEQUENCE LISTING

<110>  Yissum Research Development Company of the Hebrew 
       University of Jerusalem Ltd.
 
<120>  PROGNOSTIC KITS, ARRAYS COMPOSITIONS AND METHODS FOR PREDICTING 
       INTERFERON TREATMENT EFFICACY IN A SUBJECT

<130>  2339288

<150>  US 61/977,977
<151>  2014-04-10

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  863
<212>  DNA
<213>  Homo sapiens

<400>  1
caaggttcag agtcacccat ctcagcaagc ccagaagtat ctgcaatatc tacgatggcc       60

tcgccctttg ctttactgat ggtcctggtg gtgctcagct gcaagtcaag ctgctctctg      120

ggctgtgatc tccctgagac ccacagcctg gataacagga ggaccttgat gctcctggca      180

caaatgagca gaatctctcc ttcctcctgt ctgatggaca gacatgactt tggatttccc      240

caggaggagt ttgatggcaa ccagttccag aaggctccag ccatctctgt cctccatgag      300

ctgatccagc agatcttcaa cctctttacc acaaaagatt catctgctgc ttgggatgag      360

gacctcctag acaaattctg caccgaactc taccagcagc tgaatgactt ggaagcctgt      420

gtgatgcagg aggagagggt gggagaaact cccctgatga atgcggactc catcttggct      480

gtgaagaaat acttccgaag aatcactctc tatctgacag agaagaaata cagcccttgt      540

gcctgggagg ttgtcagagc agaaatcatg agatccctct ctttatcaac aaacttgcaa      600

gaaagattaa ggaggaagga ataacatctg gtccaacatg aaaacaattc ttattgactc      660

atacaccagg tcacgctttc atgaattctg tcatttcaaa gactctcacc cctgctataa      720

ctatgaccat gctgataaac tgatttatct atttaaatat ttatttaact attcataaga      780

tttaaattat ttttgttcat ataacgtcat gtgcaccttt acactgtggt tagtgtaata      840

aaacatgttc cttatattta ctc                                              863


<210>  2
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  3
<211>  1143
<212>  DNA
<213>  Homo sapiens

<400>  3
gagaacctgg agcctaaggt ttaggctcac ccatttcaac cagtctagca gcatctgcaa       60

catctacaat ggccttgacc tttgctttac tggtggccct cctggtgctc agctgcaagt      120

caagctgctc tgtgggctgt gatctgcctc aaacccacag cctgggtagc aggaggacct      180

tgatgctcct ggcacagatg aggagaatct ctcttttctc ctgcttgaag gacagacatg      240

actttggatt tccccaggag gagtttggca accagttcca aaaggctgaa accatccctg      300

tcctccatga gatgatccag cagatcttca atctcttcag cacaaaggac tcatctgctg      360

cttgggatga gaccctccta gacaaattct acactgaact ctaccagcag ctgaatgacc      420

tggaagcctg tgtgatacag ggggtggggg tgacagagac tcccctgatg aaggaggact      480

ccattctggc tgtgaggaaa tacttccaaa gaatcactct ctatctgaaa gagaagaaat      540

acagcccttg tgcctgggag gttgtcagag cagaaatcat gagatctttt tctttgtcaa      600

caaacttgca agaaagttta agaagtaagg aatgaaaact ggttcaacat ggaaatgatt      660

ttcattgatt cgtatgccag ctcacctttt tatgatctgc catttcaaag actcatgttt      720

ctgctatgac catgacacga tttaaatctt ttcaaatgtt tttaggagta ttaatcaaca      780

ttgtattcag ctcttaaggc actagtccct tacagaggac catgctgact gatccattat      840

ctatttaaat atttttaaaa tattatttat ttaactattt ataaaacaac ttatttttgt      900

tcatattatg tcatgtgcac ctttgcacag tggttaatgt aataaaatat gttctttgta      960

tttggtaaat ttattttgtg ttgttcattg aacttttgct atggaaactt ttgtacttgt     1020

ttattcttta aaatgaaatt ccaagcctaa ttgtgcaacc tgattacaga ataactggta     1080

cacttcattt atccatcaat attatattca agatataagt aaaaataaac tttctgtaaa     1140

cca                                                                   1143


<210>  4
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His 
65                  70                  75                  80  


Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser 
                85                  90                  95      


Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr 
            100                 105                 110         


Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val 
        115                 120                 125             


Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys 
    130                 135                 140                 


Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro 
145                 150                 155                 160 


Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu 
                165                 170                 175     


Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
            180                 185             


<210>  5
<211>  982
<212>  DNA
<213>  Homo sapiens

<400>  5
agaaaaccta gaggccgaag ttcaaggtta tccatctcaa gtagcctagc aatatttgca       60

acatcccaat ggccctgtcc ttttctttac tgatggccgt gctggtgctc agctacaaat      120

ccatctgttc tctgggctgt gatctgcctc agacccacag cctgggtaat aggagggcct      180

tgatactcct ggcacaaatg ggaagaatct ctcatttctc ctgcctgaag gacagacatg      240

atttcggatt ccccgaggag gagtttgatg gccaccagtt ccagaaggct caagccatct      300

ctgtcctcca tgagatgatc cagcagacct tcaatctctt cagcacagag gactcatctg      360

ctgcttggga acagagcctc ctagaaaaat tttccactga actttaccag caactgaatg      420

acctggaagc atgtgtgata caggaggttg gggtggaaga gactcccctg atgaatgagg      480

actccatcct ggctgtgagg aaatacttcc aaagaatcac tctttatcta acagagaaga      540

aatacagccc ttgtgcctgg gaggttgtca gagcagaaat catgagatcc ctctcgtttt      600

caacaaactt gcaaaaaaga ttaaggagga aggattgaaa cctggttcaa catggaaatg      660

atcctgattg actaatacat tatctcacac tttcatgagt tcttccattt caaagactca      720

cttctataac caccacgagt tgaatcaaaa ttttcaaatg ttttcagcag tgtgaagaag      780

cttggtgtat acctgtgcag gcactagtcc tttacagatg acaatgctga tgtctctgtt      840

catctattta tttaaatatt tatttatttt taaaatttaa attatttttt atgtgatatc      900

atgagtacct ttacattgtg gtgaatgtaa caatatatgt tcttcatatt tagccaatat      960

attaatttcc tttttcatta aa                                               982


<210>  6
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Glu Glu 
    50                  55                  60                  


Glu Phe Asp Gly His Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  7
<211>  700
<212>  DNA
<213>  Homo sapiens

<400>  7
gcccaaggtt cagggtcact caatctcaac agcccagaag catctgcaac ctccccaatg       60

gccttgccct ttgttttact gatggccctg gtggtgctca actgcaagtc aatctgttct      120

ctgggctgtg atctgcctca gacccacagc ctgagtaaca ggaggacttt gatgataatg      180

gcacaaatgg gaagaatctc tcctttctcc tgcctgaagg acagacatga ctttggattt      240

cctcaggagg agtttgatgg caaccagttc cagaaggctc aagccatctc tgtcctccat      300

gagatgatcc agcagacctt caatctcttc agcacaaagg actcatctgc tacttgggat      360

gagacacttc tagacaaatt ctacactgaa ctttaccagc agctgaatga cctggaagcc      420

tgtatgatgc aggaggttgg agtggaagac actcctctga tgaatgtgga ctctatcctg      480

actgtgagaa aatactttca aagaatcacc ctctatctga cagagaagaa atacagccct      540

tgtgcatggg aggttgtcag agcagaaatc atgagatcct tctctttatc agcaaacttg      600

caagaaagat taaggaggaa ggaatgaaaa ctggttcaac atcgaaatga ttctcattga      660

ctagtacacc atttcacact tcttgagttc tgccgtttca                            700


<210>  8
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Leu Pro Phe Val Leu Leu Met Ala Leu Val Val Leu Asn Cys 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Ser Asn Arg Arg Thr Leu Met Ile Met Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Met Met Gln Glu Val Gly 
        115                 120                 125             


Val Glu Asp Thr Pro Leu Met Asn Val Asp Ser Ile Leu Thr Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ala Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  9
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  9
atggctttgc cttttgcttt actgatggcc ctggtggtgc tcagctgcaa gtcaagctgc       60

tctctggact gtgatctgcc tcagacccac agcctgggtc acaggaggac catgatgctc      120

ctggcacaaa tgaggagaat ctctcttttc tcctgtctga aggacagaca tgacttcaga      180

tttccccagg aggagtttga tggcaaccag ttccagaagg ctgaagccat ctctgtcctc      240

catgaggtga ttcagcagac cttcaacctc ttcagcacaa aggactcatc tgttgcttgg      300

gatgagaggc ttctagacaa actctatact gaactttacc agcagctgaa tgacctggaa      360

gcctgtgtga tgcaggaggt gtgggtggga gggactcccc tgatgaatga ggactccatc      420

ctggctgtga gaaaatactt ccaaagaatc actctctacc tgacagagaa aaagtacagc      480

ccttgtgcct gggaggttgt cagagcagaa atcatgagat ccttctcttc atcaagaaac      540

ttgcaagaaa ggttaaggag gaaggaataa                                       570


<210>  10
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Leu Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Asp Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly His Arg Arg Thr Met Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Glu Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Val Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Val Ala Trp Asp Glu Arg Leu Leu Asp Lys Leu Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Val Trp 
        115                 120                 125             


Val Gly Gly Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Ser Ser Arg Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  11
<211>  736
<212>  DNA
<213>  Homo sapiens

<400>  11
tacccacctc aggtagccta gtgatatttg caaaatccca atggcccggt ccttttcttt       60

actgatggtc gtgctggtac tcagctacaa atccatctgc tctctgggct gtgatctgcc      120

tcagacccac agcctgcgta ataggagggc cttgatactc ctggcacaaa tgggaagaat      180

ctctcctttc tcctgcttga aggacagaca tgaattcaga ttcccagagg aggagtttga      240

tggccaccag ttccagaaga ctcaagccat ctctgtcctc catgagatga tccagcagac      300

cttcaatctc ttcagcacag aggactcatc tgctgcttgg gaacagagcc tcctagaaaa      360

attttccact gaactttacc agcaactgaa tgacctggaa gcatgtgtga tacaggaggt      420

tggggtggaa gagactcccc tgatgaatga ggacttcatc ctggctgtga ggaaatactt      480

ccaaagaatc actctttatc taatggagaa gaaatacagc ccttgtgcct gggaggttgt      540

cagagcagaa atcatgagat ccttctcttt ttcaacaaac ttgaaaaaag gattaaggag      600

gaaggattga aaactggttc atcatggaaa tgattctcat tgactaatgc atcatctcac      660

actttcatga gttcttccat ttcaaagact cacttctata accaccacaa gttaatcaaa      720

atttccaaat gttttc                                                      736


<210>  12
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Arg Ser Phe Ser Leu Leu Met Val Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Arg Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Glu Phe Arg Phe Pro Glu Glu 
    50                  55                  60                  


Glu Phe Asp Gly His Gln Phe Gln Lys Thr Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Phe Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Lys Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  13
<211>  1039
<212>  DNA
<213>  Homo sapiens

<400>  13
accagctcag cagcatccac aacatctaca atggccttga ctttttattt actggtggcc       60

ctagtggtgc tcagctacaa gtcattcagc tctctgggct gtgatctgcc tcagactcac      120

agcctgggta acaggagggc cttgatactc ctggcacaaa tgcgaagaat ctctcctttc      180

tcctgcctga aggacagaca tgactttgaa ttcccccagg aggagtttga tgataaacag      240

ttccagaagg ctcaagccat ctctgtcctc catgagatga tccagcagac cttcaacctc      300

ttcagcacaa aggactcatc tgctgctttg gatgagaccc ttctagatga attctacatc      360

gaacttgacc agcagctgaa tgacctggag tcctgtgtga tgcaggaagt gggggtgata      420

gagtctcccc tgatgtacga ggactccatc ctggctgtga ggaaatactt ccaaagaatc      480

actctatatc tgacagagaa gaaatacagc tcttgtgcct gggaggttgt cagagcagaa      540

atcatgagat ccttctcttt atcaatcaac ttgcaaaaaa gattgaagag taaggaatga      600

gacctggtac aacacggaaa tgattcttat agactaatac agcagctcac acttcgacaa      660

gttgtgctct ttcaaagacc cttgtttctg ccaaaaccat gctatgaatt gaatcaaatg      720

tgtcaagtgt tttcaggagt gttaagcaac atcctgttca gctgtatggg cactagtccc      780

ttacagatga ccatgctgat ggatctattc atctatttat ttaaatcttt atttagttaa      840

ctatctatag ggcttaaatt agttttgttc atattatatt atgtgaactt ttacattgtg      900

aattgtgtaa caaaaacatg ttctttatat ttattatttt gccttgttta ttaaattttt      960

actatagaaa aattctttat ttattcttta aaattgaact ccaaccctga ttgtgcaaac     1020

tgattaaaga atggatggt                                                  1039


<210>  14
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Leu Thr Phe Tyr Leu Leu Val Ala Leu Val Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Phe Ser Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Glu Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Asp Lys Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Leu Asp Glu Thr Leu Leu Asp Glu Phe Tyr Ile Glu Leu 
            100                 105                 110         


Asp Gln Gln Leu Asn Asp Leu Glu Ser Cys Val Met Gln Glu Val Gly 
        115                 120                 125             


Val Ile Glu Ser Pro Leu Met Tyr Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Ser Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ile Asn Leu Gln Lys Arg Leu Lys Ser Lys Glu 
            180                 185                 


<210>  15
<211>  963
<212>  DNA
<213>  Homo sapiens

<400>  15
caaggttatc catctcaagt agcctagcaa tatttgcaac atcccaatgg ccctgtcctt       60

ttctttactt atggccgtgc tggtgctcag ctacaaatcc atctgttctc tgggctgtga      120

tctgcctcag acccacagcc tcggtaatag gagggccttg atactcctgg gacaaatggg      180

aagaatctct cctttctcct gcctgaagga cagacatgat ttccgaatcc cccaggagga      240

gtttgatggc aaccagttcc agaaggctca agccatctct gtcctccatg agatgatcca      300

gcagaccttc aatctcttca gcacagagga ctcatctgct gcttgggaac agagcctcct      360

agaaaaattt tccactgaac tttaccagca actgaatgac ctggaagcat gtgtgataca      420

ggaggttggg gtggaagaga ctcccctgat gaatgaggac tccatcctgg ctgtgaggaa      480

atacttccaa agaatcactc tttatctaat agagaggaaa tacagccctt gtgcctggga      540

ggttgtcaga gcagaaatca tgagatccct ctcgttttca acaaacttgc aaaaaagatt      600

aaggaggaag gattgaaaac tggttcaaca tggcaatgat cctgattgac taatacatta      660

tctcacactt tcatgagttc ttccatttca aagactcact tctataacca cgacgcgttg      720

aatcaaaatt ttcaaatgtt ttcagcagtg taaagaagtg tcgtgtatac ctgtgcaggc      780

actagtcctt tacagatgac cattctgatg tctctgttca tcttttgttt aaatatttat      840

ttaattattt ttaaaattta tgtaatatca tgagtcgctt tacattgtgg ttaatgtaac      900

aatatatgtt cttcatattt agccaatata ttaatttcct ttttcattaa atttttacta      960

tac                                                                    963


<210>  16
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Gly Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Ile Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Ile Glu Arg Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  17
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  17
agagaaccta gagcccaagg ttcagagtca cccatctcag caagcccaga agcatctgca       60

atatctatga tggcctcgcc ctttgcttta ctgatggccc tggtggtgct cagctgcaag      120

tcaagctgct ctctgggctg tgatctccct gagacccaca gcctggataa caggaggacc      180

ttgatgctcc tggcacaaat gagcagaatc tctccttcct cctgtctgat ggacagacat      240

gactttggat ttccccagga ggagtttgat ggcaaccagt tccagaaggc tccagccatc      300

tctgtcctcc atgagctgat ccagcagatc ttcaacctct ttaccacaaa agattcatct      360

gctgcttggg atgaggacct cctagacaaa ttctgcaccg aactctacca gcagctgaat      420

gacttggaag cctgtgtgat gcaggaggag agggtgggag aaactcccct gatgaatgcg      480

gactccatct tggctgtgaa gaaatacttc cgaagaatca ctctctatct gacagagaag      540

aaatacagcc cttgtgcctg ggaggttgtc agagcagaaa tcatgagatc cctctcttta      600

tcaacaaact tgcaagaaag attaaggagg aaggaataac acctggtcca acatgaaaca      660

attcttattg actcatatac caggtcacgc tttcatgaat tctgc                      705


<210>  18
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Met Ala Ser Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser 
1               5                   10                  15      


Cys Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser 
            20                  25                  30          


Leu Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile 
        35                  40                  45              


Ser Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln 
    50                  55                  60                  


Glu Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val 
65                  70                  75                  80  


Leu His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp 
                85                  90                  95      


Ser Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu 
            100                 105                 110         


Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu 
        115                 120                 125             


Arg Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val 
    130                 135                 140                 


Lys Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr 
145                 150                 155                 160 


Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu 
                165                 170                 175     


Ser Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 190 


<210>  19
<211>  778
<212>  DNA
<213>  Homo sapiens

<400>  19
gttacccctc atcaaccagc ccagcagcat cttcgggatt cccaatggca ttgccctttg       60

ctttaatgat ggccctggtg gtgctcagct gcaagtcaag ctgctctctg ggctgtaatc      120

tgtctcaaac ccacagcctg aataacagga ggactttgat gctcatggca caaatgagga      180

gaatctctcc tttctcctgc ctgaaggaca gacatgactt tgaatttccc caggaggaat      240

ttgatggcaa ccagttccag aaagctcaag ccatctctgt cctccatgag atgatgcagc      300

agaccttcaa tctcttcagc acaaagaact catctgctgc ttgggatgag accctcctag      360

aaaaattcta cattgaactt ttccagcaaa tgaatgacct ggaagcctgt gtgatacagg      420

aggttggggt ggaagagact cccctgatga atgaggactc catcctggct gtgaagaaat      480

acttccaaag aatcactctt tatctgatgg agaagaaata cagcccttgt gcctgggagg      540

ttgtcagagc agaaatcatg agatccctct ctttttcaac aaacttgcaa aaaagattaa      600

ggaggaagga ttgaaaactg gttcatcatg gaaatgattc tcattgacta atacatcatc      660

tcacactttc atgagttctt ccatttcaaa gactcacttc tcctataacc accacaagtt      720

gaatcaaaat tttcaaatgt tttcaggagt gtaaagaagc atcatgtata cctgtgca        778


<210>  20
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Leu Pro Phe Ala Leu Met Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asn Leu Ser Gln Thr His Ser Leu 
            20                  25                  30          


Asn Asn Arg Arg Thr Leu Met Leu Met Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Glu Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Met Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asn Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Glu Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Met Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  21
<211>  939
<212>  DNA
<213>  Homo sapiens

<400>  21
atcccaatgg ccctgtcctt ttctttactg atggccgtgc tggtgctcag ctacaaatcc       60

atctgttctc tgggctgtga tctgcctcag actcacagcc tgggtaatag gagggccttg      120

atactcctgg cacaaatggg aagaatctct catttctcct gcctgaagga cagatatgat      180

ttcggattcc cccaggaggt gtttgatggc aaccagttcc agaaggctca agccatctct      240

gccttccatg agatgatcca gcagaccttc aatctcttca gcacaaagga ttcatctgct      300

gcttgggatg agaccctcct agacaaattc tacattgaac ttttccagca actgaatgac      360

ctagaagcct gtgtgacaca ggaggttggg gtggaagaga ttgccctgat gaatgaggac      420

tccatcctgg ctgtgaggaa atactttcaa agaatcactc tttatctgat ggggaagaaa      480

tacagccctt gtgcctggga ggttgtcaga gcagaaatca tgagatcctt ctctttttca      540

acaaacttgc aaaaaggatt aagaaggaag gattgaaaac tcattcaaca tggaaatgat      600

cctcattgat taatacatca tctcacactt tcatgagttc ttccatttca aagactcact      660

tctataacca ccacaagttg aatcaaaatt tcaaaatgtt ttcaggagtg taaagaagca      720

tcgtgtttac ctgtgcaggc actagtcctt tacagatgac catgctgatg tctctattca      780

tctatttatt taaatattta tttatttaac tatttttaag gtttaaatca tgttttatgt      840

aatatcatgt gtacctttac attttgctta atgtaacaat atatgttctt catatttagt      900

taatatatta acttcctttt cattaaattt ttactatac                             939


<210>  22
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg Tyr Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Val Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Ala Phe 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Thr Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Ile Ala Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Gly Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  23
<211>  980
<212>  DNA
<213>  Homo sapiens

<400>  23
gttcaaggtt acccatctca agtagcctag caacatttgc aacatcccaa tggccctgtc       60

cttttcttta ctgatggccg tgctggtgct cagctacaaa tccatctgtt ctctaggctg      120

tgatctgcct cagacccaca gcctgggtaa taggagggcc ttgatactcc tggcacaaat      180

gggaagaatc tctcctttct cctgcctgaa ggacagacat gactttggac ttccccagga      240

ggagtttgat ggcaaccagt tccagaagac tcaagccatc tctgtcctcc atgagatgat      300

ccagcagacc ttcaatctct tcagcacaga ggactcatct gctgcttggg aacagagcct      360

cctagaaaaa ttttccactg aactttacca gcaactgaat aacctggaag catgtgtgat      420

acaggaggtt gggatggaag agactcccct gatgaatgag gactccatcc tggctgtgag      480

gaaatacttc caaagaatca ctctttatct aacagagaag aaatacagcc cttgtgcctg      540

ggaggttgtc agagcagaaa tcatgagatc tctctctttt tcaacaaact tgcaaaaaat      600

attaaggagg aaggattgaa aactggttca acatggcaat gatcctgatt gactaataca      660

ttatctcaca ctttcatgag ttcctccatt tcaaagactc acttctataa ccaccacgag      720

ttgaatcaaa attttcaaat gttttcagca gtgtaaagaa gcgtcgtgta tacctgtgca      780

ggcactagta ctttacagat gaccatgctg atgtctctgt tcatctattt atttaaatat      840

ttatttaatt atttttaaga tttaaattat ttttttatgt aatatcatgt gtacctttac      900

attgtggtga atgtaacaat atatgttctt catatttagc caatatatta atttcctttt      960

tcattaaatt tttactatac                                                  980


<210>  24
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Leu Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Thr Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asn Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Met Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Ile Leu Arg Arg Lys Asp 
            180                 185                 


<210>  25
<211>  1024
<212>  DNA
<213>  Homo sapiens

<400>  25
ttcaaggtta cccatctcaa gtagcctagc aatattggca acatcccaat ggccctgtcc       60

ttttctttac tgatggccgt gctggtgctc agctacaaat ccatctgttc tctgggctgt      120

gatctgcctc agacccacag cctgggtaat aggagggcct tgatactcct ggcacaaatg      180

ggaagaatct ctcctttctc ctgcctgaag gacagacatg actttggatt cccccaggag      240

gagtttgatg gcaaccagtt ccagaaggct caagccatct ctgtcctcca tgagatgatc      300

cagcagacct tcaatctctt cagcacaaag gactcatctg ctacttggga acagagcctc      360

ctagaaaaat tttccactga acttaaccag cagctgaatg acctggaagc ctgcgtgata      420

caggaggttg gggtggaaga gactcccctg atgaatgtgg actccatcct ggctgtgaag      480

aaatacttcc aaagaatcac tctttatctg acagagaaga aatacagccc ttgtgcctgg      540

gaggttgtca gagcagaaat catgagatcc ttctctttat caaaaatttt tcaagaaaga      600

ttaaggagga aggaatgaaa cctgtttcaa catggaaatg atctgtattg actaatacac      660

cagtccacac ttctatgact tctgccattt caaagactca tttctcctat aaccaccgca      720

tgagttgaat caaaattttc agatcttttc aggagtgtaa ggaaacatca tgtttacctg      780

tgcaggcact agtcctttac agatgaccat gctgatagat ctaattatct atctattgaa      840

atatttattt atttattaga tttaaattat ttttgtccat gtaatattat gtgtactttt      900

acattgtgtt atatcaaaat atgttattta tatttagtca atatattatt ttctttttat      960

taatttttac tattaaaact tcttatatta tttgtttatt ctttaataaa gaaataccaa     1020

gccc                                                                  1024


<210>  26
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Asn Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Val Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Lys Ile Phe Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  27
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  27
acattctaac tgcaaccttt cgaagccttt gctctggcac aacaggtagt aggcgacact       60

gttcgtgttg tcaacatgac caacaagtgt ctcctccaaa ttgctctcct gttgtgcttc      120

tccactacag ctctttccat gagctacaac ttgcttggat tcctacaaag aagcagcaat      180

tttcagtgtc agaagctcct gtggcaattg aatgggaggc ttgaatactg cctcaaggac      240

aggatgaact ttgacatccc tgaggagatt aagcagctgc agcagttcca gaaggaggac      300

gccgcattga ccatctatga gatgctccag aacatctttg ctattttcag acaagattca      360

tctagcactg gctggaatga gactattgtt gagaacctcc tggctaatgt ctatcatcag      420

ataaaccatc tgaagacagt cctggaagaa aaactggaga aagaagattt caccagggga      480

aaactcatga gcagtctgca cctgaaaaga tattatggga ggattctgca ttacctgaag      540

gccaaggagt acagtcactg tgcctggacc atagtcagag tggaaatcct aaggaacttt      600

tacttcatta acagacttac aggttacctc cgaaactgaa gatctcctag cctgtgcctc      660

tgggactgga caattgcttc aagcattctt caaccagcag atgctgttta agtgactgat      720

ggctaatgta ctgcatatga aaggacacta gaagattttg aaatttttat taaattatga      780

gttattttta tttatttaaa ttttattttg gaaaataaat tatttttggt gcaaaagtca      840


<210>  28
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  29
<211>  1514
<212>  DNA
<213>  Homo sapiens

<400>  29
gatctggtaa acctgaagca aatatagaaa cctatagggc ctgacttcct acataaagta       60

aggagggtaa aaatggaggc tagaataagg gttaaaattt tgcttctaga acagagaaaa      120

tgattttttt catatatata tgaatatata ttatatatac acatatatac atatattcac      180

tatagtgtgt atacataaat atataatata tatattgtta gtgtagtgtg tgtctgatta      240

tttacatgca tatagtatat acacttatga ctttagtacc cagacgtttt tcatttgatt      300

aagcattcat ttgtattgac acagctgaag tttactggag tttagctgaa gtctaatgca      360

aaattaatag attgttgtca tcctcttaag gtcataggga gaacacacaa atgaaaacag      420

taaaagaaac tgaaagtaca gagaaatgtt cagaaaatga aaaccatgtg tttcctatta      480

aaagccatgc atacaagcaa tgtcttcaga aaacctaggg tccaaggtta agccatatcc      540

cagctcagta aagccaggag catcctcatt tcccaatggc cctcctgttc cctctactgg      600

cagccctagt gatgaccagc tatagccctg ttggatctct gggctgtgat ctgcctcaga      660

accatggcct acttagcagg aacaccttgg tgcttctgca ccaaatgagg agaatctccc      720

ctttcttgtg tctcaaggac agaagagact tcaggttccc ccaggagatg gtaaaaggga      780

gccagttgca gaaggcccat gtcatgtctg tcctccatga gatgctgcag cagatcttca      840

gcctcttcca cacagagcgc tcctctgctg cctggaacat gaccctccta gaccaactcc      900

acactggact tcatcagcaa ctgcaacacc tggagacctg cttgctgcag gtagtgggag      960

aaggagaatc tgctggggca attagcagcc ctgcactgac cttgaggagg tacttccagg     1020

gaatccgtgt ctacctgaaa gagaagaaat acagcgactg tgcctgggaa gttgtcagaa     1080

tggaaatcat gaaatccttg ttcttatcaa caaacatgca agaaagactg agaagtaaag     1140

atagagacct gggctcatct tgaaatgatt ctcattgatt aatttgccat ataacacttg     1200

cacatgtgac tctggtcaat tcaaaagact cttatttcgg ctttaatcac agaattgact     1260

gaattagttc tgcaaatact ttgtcggtat attaagccag tatatgttaa aaagacttag     1320

gttcaggggc atcagtccct aagatgttat ttatttttac tcatttattt attcttacat     1380

tttatcatat ttatactatt tatattctta tataacaaat gtttgccttt acattgtatt     1440

aagataacaa aacatgttca gctttccatt tggttaaata ttgtattttg ttatttatta     1500

aattattttc aaac                                                       1514


<210>  30
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Leu Leu Phe Pro Leu Leu Ala Ala Leu Val Met Thr Ser Tyr 
1               5                   10                  15      


Ser Pro Val Gly Ser Leu Gly Cys Asp Leu Pro Gln Asn His Gly Leu 
            20                  25                  30          


Leu Ser Arg Asn Thr Leu Val Leu Leu His Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Leu Cys Leu Lys Asp Arg Arg Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Met Val Lys Gly Ser Gln Leu Gln Lys Ala His Val Met Ser Val Leu 
65                  70                  75                  80  


His Glu Met Leu Gln Gln Ile Phe Ser Leu Phe His Thr Glu Arg Ser 
                85                  90                  95      


Ser Ala Ala Trp Asn Met Thr Leu Leu Asp Gln Leu His Thr Gly Leu 
            100                 105                 110         


His Gln Gln Leu Gln His Leu Glu Thr Cys Leu Leu Gln Val Val Gly 
        115                 120                 125             


Glu Gly Glu Ser Ala Gly Ala Ile Ser Ser Pro Ala Leu Thr Leu Arg 
    130                 135                 140                 


Arg Tyr Phe Gln Gly Ile Arg Val Tyr Leu Lys Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Asp Cys Ala Trp Glu Val Val Arg Met Glu Ile Met Lys Ser Leu Phe 
                165                 170                 175     


Leu Ser Thr Asn Met Gln Glu Arg Leu Arg Ser Lys Asp Arg Asp Leu 
            180                 185                 190         


Gly Ser Ser 
        195 


<210>  31
<211>  1240
<212>  DNA
<213>  Homo sapiens

<400>  31
cacattgttc tgatcatctg aagatcagct attagaagag aaagatcagt taagtccttt       60

ggacctgatc agcttgatac aagaactact gatttcaact tctttggctt aattctctcg      120

gaaacgatga aatatacaag ttatatcttg gcttttcagc tctgcatcgt tttgggttct      180

cttggctgtt actgccagga cccatatgta aaagaagcag aaaaccttaa gaaatatttt      240

aatgcaggtc attcagatgt agcggataat ggaactcttt tcttaggcat tttgaagaat      300

tggaaagagg agagtgacag aaaaataatg cagagccaaa ttgtctcctt ttacttcaaa      360

ctttttaaaa actttaaaga tgaccagagc atccaaaaga gtgtggagac catcaaggaa      420

gacatgaatg tcaagttttt caatagcaac aaaaagaaac gagatgactt cgaaaagctg      480

actaattatt cggtaactga cttgaatgtc caacgcaaag caatacatga actcatccaa      540

gtgatggctg aactgtcgcc agcagctaaa acagggaagc gaaaaaggag tcagatgctg      600

tttcgaggtc gaagagcatc ccagtaatgg ttgtcctgcc tgcaatattt gaattttaaa      660

tctaaatcta tttattaata tttaacatta tttatatggg gaatatattt ttagactcat      720

caatcaaata agtatttata atagcaactt ttgtgtaatg aaaatgaata tctattaata      780

tatgtattat ttataattcc tatatcctgt gactgtctca cttaatcctt tgttttctga      840

ctaattaggc aaggctatgt gattacaagg ctttatctca ggggccaact aggcagccaa      900

cctaagcaag atcccatggg ttgtgtgttt atttcacttg atgatacaat gaacacttat      960

aagtgaagtg atactatcca gttactgccg gtttgaaaat atgcctgcaa tctgagccag     1020

tgctttaatg gcatgtcaga cagaacttga atgtgtcagg tgaccctgat gaaaacatag     1080

catctcagga gatttcatgc ctggtgcttc caaatattgt tgacaactgt gactgtaccc     1140

aaatggaaag taactcattt gttaaaatta tcaatatcta atatatatga ataaagtgta     1200

agttcacaac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           1240


<210>  32
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  33
<211>  3539
<212>  DNA
<213>  Homo sapiens

<400>  33
caagagttgg taagctcgct gcagtgggtg gagagaggcc tctagacttc agtttcagtt       60

tcctggctct gggcagcagc aagaattcct ctgcctccca tcctaccatt cactgtcttg      120

ccggcagcca gctgagagca atgggaaatg gggagtccca gctgtcctcg gtgcctgctc      180

agaagctggg ttggtttatc caggaatacc tgaagcccta cgaagaatgt cagacactga      240

tcgacgagat ggtgaacacc atctgtgacg tcctgcagga acccgaacag ttccccctgg      300

tgcagggagt ggccataggt ggctcctatg gacggaaaac agtcttaaga ggcaactccg      360

atggtaccct tgtcctcttc ttcagtgact taaaacaatt ccaggatcag aagagaagcc      420

aacgtgacat cctcgataaa actggggata agctgaagtt ctgtctgttc acgaagtggt      480

tgaaaaacaa tttcgagatc cagaagtccc ttgatgggtt caccatccag gtgttcacaa      540

aaaatcagag aatctctttc gaggtgctgg ccgccttcaa cgctctgagc ttaaatgata      600

atcccagccc ctggatctat cgagagctca aaagatcctt ggataagaca aatgccagtc      660

ctggtgagtt tgcagtctgc ttcactgaac tccagcagaa gttttttgac aaccgtcctg      720

gaaaactaaa ggatttgatc ctcttgataa agcactggca tcaacagtgc cagaaaaaaa      780

tcaaggattt accctcgctg tctccgtatg ccctggagct gcttacggtg tatgcctggg      840

aacaggggtg cagaaaagac aactttgaca ttgctgaagg cgtcagaacc gtactggagc      900

tgatcaaatg ccaggagaag ctgtgtatct attggatggt caactacaac tttgaagatg      960

agaccatcag gaacatcctg ctgcaccagc tccaatcagc gaggccagta atcttggatc     1020

cagttgaccc aaccaataat gtgagtggag ataaaatatg ctggcaatgg ctgaaaaaag     1080

aagctcaaac ctggttgact tctcccaacc tggataatga gttacctgca ccatcttgga     1140

atgttctgcc tgcaccactc ttcacgaccc caggccacct tctggataag ttcatcaagg     1200

agtttctcca gcccaacaaa tgcttcctag agcagattga cagtgctgtt aacatcatcc     1260

gtacattcct taaagaaaac tgcttccgac aatcaacagc caagatccag attgtccggg     1320

gaggatcaac cgccaaaggc acagctctga agactggctc tgatgccgat ctcgtcgtgt     1380

tccataactc acttaaaagc tacacctccc aaaaaaacga gcggcacaaa atcgtcaagg     1440

aaatccatga acagctgaaa gccttttgga gggagaagga ggaggagctt gaagtcagct     1500

ttgagcctcc caagtggaag gctcccaggg tgctgagctt ctctctgaaa tccaaagtcc     1560

tcaacgaaag tgtcagcttt gatgtgcttc ctgcctttaa tgcactgggt cagctgagtt     1620

ctggctccac acccagcccc gaggtttatg cagggctcat tgatctgtat aaatcctcgg     1680

acctcccggg aggagagttt tctacctgtt tcacagtcct gcagcgaaac ttcattcgct     1740

cccggcccac caaactaaag gatttaattc gcctggtgaa gcactggtac aaagagtgtg     1800

aaaggaaact gaagccaaag gggtctttgc ccccaaagta tgccttggag ctgctcacca     1860

tctatgcctg ggagcagggg agtggagtgc cggattttga cactgcagaa ggtttccgga     1920

cagtcctgga gctggtcaca caatatcagc agctctgcat cttctggaag gtcaattaca     1980

actttgaaga tgagaccgtg aggaagtttc tactgagcca gttgcagaaa accaggcctg     2040

tgatcttgga cccagccgaa cccacaggtg acgtgggtgg aggggaccgt tggtgttggc     2100

atcttctggc aaaagaagca aaggaatggt tatcctctcc ctgcttcaag gatgggactg     2160

gaaacccaat accaccttgg aaagtgccga caatgcagac accaggaagt tgtggagcta     2220

ggatccatcc tattgtcaat gagatgttct catccagaag ccatagaatc ctgaataata     2280

attctaaaag aaacttctag agatcatctg gcaatcgctt ttaaagactc ggctcaccgt     2340

gagaaagagt cactcacatc cattcttccc ttgatggtcc ctattcctcc ttcccttgct     2400

tcttggactt cttgaaatca atcaagactg caaacccttt cataaagtct tgccttgctg     2460

aactccctct ctgcaggcag cctgccttta aaaatagttg ctgtcatcca ctttatgtgc     2520

atcttatttc tgtcaacttg tatttttttt cttgtatttt tccaattagc tcctcctttt     2580

tccttccagt ctaaaaaagg aatcctctgt gtcttcaaag caaagctctt tactttcccc     2640

ttggttctca taactctgtg atcttgctct cggtgcttcc aactcatcca cgtcctgtct     2700

gtttcctctg tatacaaaac cctttctgcc cctgctgaca cagacatcct ctatgccagc     2760

agccagccaa ccctttcatt agaacttcaa gctctccaaa ggctcagatt ataactgttg     2820

tcatatttat atgaggctgt tgtcttttcc ttctgagcct gcctttctcc cccccaccca     2880

ggagtatcct cttgccaaat caaaagactt tttccttggg ctttagcctt aaagatactt     2940

gaaggtctag gtgctttaac ctcacatacc ctcacttaaa cttttatcac tgttgcatat     3000

accagttgtg atacaataaa gaatgtatct ggattttgtg cctagttcct agcacacagc     3060

ttcaaaaatt ctagagtttc ctgataggag tgtcttttgt attcataaca agcccttttc     3120

acccatgcct gggtttatgc taacaaggtt acccatggtg ggcccttagt ttcaaggaag     3180

gagttggcca agccagaaag accaagcatg tggttaaagc attggaattt tcagccccat     3240

cccaccccca atctccaagg aggtgatggg gctggaaatt gagttcaatt ttaacatggc     3300

cagtgattta agcaatgctg cctatgtaaa gaaaccccaa taaaaactct ggacagtgag     3360

gcttggggag cttcctgatt ggcagacatt ccaatgtact aggaaggtag cgcatcttga     3420

ttccacaggg acaaaggctc ctgagctctg ggcccttcca gtgcttgcca ccctacatac     3480

tctttgtctg gctcttcatt tgtattcttt ataataaaat ggtgattgta agtagagca      3539


<210>  34
<211>  3647
<212>  DNA
<213>  Homo sapiens

<400>  34
caagagttgg taagctcgct gcagtgggtg gagagaggcc tctagacttc agtttcagtt       60

tcctggctct gggcagcagc aagaattcct ctgcctccca tcctaccatt cactgtcttg      120

ccggcagcca gctgagagca atgggaaatg gggagtccca gctgtcctcg gtgcctgctc      180

agaagctggg ttggtttatc caggaatacc tgaagcccta cgaagaatgt cagacactga      240

tcgacgagat ggtgaacacc atctgtgacg tcctgcagga acccgaacag ttccccctgg      300

tgcagggagt ggccataggt ggctcctatg gacggaaaac agtcttaaga ggcaactccg      360

atggtaccct tgtcctcttc ttcagtgact taaaacaatt ccaggatcag aagagaagcc      420

aacgtgacat cctcgataaa actggggata agctgaagtt ctgtctgttc acgaagtggt      480

tgaaaaacaa tttcgagatc cagaagtccc ttgatgggtt caccatccag gtgttcacaa      540

aaaatcagag aatctctttc gaggtgctgg ccgccttcaa cgctctgagc ttaaatgata      600

atcccagccc ctggatctat cgagagctca aaagatcctt ggataagaca aatgccagtc      660

ctggtgagtt tgcagtctgc ttcactgaac tccagcagaa gttttttgac aaccgtcctg      720

gaaaactaaa ggatttgatc ctcttgataa agcactggca tcaacagtgc cagaaaaaaa      780

tcaaggattt accctcgctg tctccgtatg ccctggagct gcttacggtg tatgcctggg      840

aacaggggtg cagaaaagac aactttgaca ttgctgaagg cgtcagaacc gtactggagc      900

tgatcaaatg ccaggagaag ctgtgtatct attggatggt caactacaac tttgaagatg      960

agaccatcag gaacatcctg ctgcaccagc tccaatcagc gaggccagta atcttggatc     1020

cagttgaccc aaccaataat gtgagtggag ataaaatatg ctggcaatgg ctgaaaaaag     1080

aagctcaaac ctggttgact tctcccaacc tggataatga gttacctgca ccatcttgga     1140

atgttctgcc tgcaccactc ttcacgaccc caggccacct tctggataag ttcatcaagg     1200

agtttctcca gcccaacaaa tgcttcctag agcagattga cagtgctgtt aacatcatcc     1260

gtacattcct taaagaaaac tgcttccgac aatcaacagc caagatccag attgtccggg     1320

gaggatcaac cgccaaaggc acagctctga agactggctc tgatgccgat ctcgtcgtgt     1380

tccataactc acttaaaagc tacacctccc aaaaaaacga gcggcacaaa atcgtcaagg     1440

aaatccatga acagctgaaa gccttttgga gggagaagga ggaggagctt gaagtcagct     1500

ttgagcctcc caagtggaag gctcccaggg tgctgagctt ctctctgaaa tccaaagtcc     1560

tcaacgaaag tgtcagcttt gatgtgcttc ctgcctttaa tgcactgggt cagctgagtt     1620

ctggctccac acccagcccc gaggtttatg cagggctcat tgatctgtat aaatcctcgg     1680

acctcccggg aggagagttt tctacctgtt tcacagtcct gcagcgaaac ttcattcgct     1740

cccggcccac caaactaaag gatttaattc gcctggtgaa gcactggtac aaagagtgtg     1800

aaaggaaact gaagccaaag gggtctttgc ccccaaagta tgccttggag ctgctcacca     1860

tctatgcctg ggagcagggg agtggagtgc cggattttga cactgcagaa ggtttccgga     1920

cagtcctgga gctggtcaca caatatcagc agctctgcat cttctggaag gtcaattaca     1980

actttgaaga tgagaccgtg aggaagtttc tactgagcca gttgcagaaa accaggcctg     2040

tgatcttgga cccagccgaa cccacaggtg acgtgggtgg aggggaccgt tggtgttggc     2100

atcttctggc aaaagaagca aaggaatggt tatcctctcc ctgcttcaag gatgggactg     2160

gaaacccaat accaccttgg aaagtgccgg taaaagtcat ctaaaggagg cgttgtctgg     2220

aaatagccct gtaacaggct tgaatcaaag aacttctcct actgtagcaa cctgaaatta     2280

actcagacac aaataaagga aacccagctc acaggagctt aaacagctgg tcagccccct     2340

aagcccccac tacaagtgat cctcaggcag gtaaccccag attcatgcac tgtagggtgc     2400

tgcgcagcat ccctagtctc tacccagtag atgccactag ccctcctctc ccagtgacaa     2460

ccaaaagtct tcagacattg tcaaacgttc ccctgggttc acagatcttt ctgcctttgg     2520

cttttggctc caccctcttt agctgttaat ttgagtactt atggccctga aagcggccac     2580

ggtgcctcca gatggcaggt ttgcaatcca agcaggaaga aggaaaagat acccaaaggt     2640

caagaacaca gtgattttat tagaagtttc atccgcaaat tttcttccat ttcattgctc     2700

agaaatgtca tgtggctacc tgtaacttga aggtggctac aaagatgact gtggacgtgg     2760

gttgcactgg ccacccaagg atgtctgcca cacctctcca aagccctccc tacctaccaa     2820

gatatacctg atatattcca ccaggatatc ctccctccag atatacttgg ttctctccac     2880

caggttcttt ctttaaagca ggatttctca actttgatac ttactcacat ttggggctag     2940

acagttcttt gtttggaggc tctcttgtgc attgtaggat gttgagcagc atctctggcc     3000

tgtacccagt agatgccacc cagttgtgac aattaaaagt gtcttgagac tttatcatgt     3060

gtcttctgcc ctaggtgaga acccttgcac tagaggaacc ctacacccca accctggggg     3120

gaatgtaggg aagaggtggc caagccaacc gtggggttag ctctaattat taagatatgc     3180

attataaata aataccaaaa aattgtctct ggcaatagtt accttcccag atacaggtcc     3240

cccctttttt cccctaactc ttttaagcaa tgattgtaac tattaggaga cattgctctc     3300

ccacgtatgt ttttcttttt agacaatgca gacaccagga agttgtggag ctaggatcca     3360

tcctattgtc aatgagatgt tctcatccag aagccataga atcctgaata ataattctaa     3420

aagaaacttc tagagatcat ctggcaatcg cttttaaaga ctcggctcac cgtgagaaag     3480

agtcactcac atccattctt cccttgatgg tccctattcc tccttccctt gcttcttgga     3540

cttcttgaaa tcaatcaaga ctgcaaaccc tttcataaag tcttgccttg ctgaactccc     3600

tctctgcagg cagcctgcct ttaaaaatag ttgctgtcat ccacttt                   3647


<210>  35
<211>  2123
<212>  DNA
<213>  Homo sapiens

<400>  35
caagagttgg taagctcgct gcagtgggtg gagagaggcc tctagacttc agtttcagtt       60

tcctggctct gggcagcagc aagaattcct ctgcctccca tcctaccatt cactgtcttg      120

ccggcagcca gctgagagca atgggaaatg gggagtccca gctgtcctcg gtgcctgctc      180

agaagctggg ttggtttatc caggaatacc tgaagcccta cgaagaatgt cagacactga      240

tcgacgagat ggtgaacacc atctgtgacg tcctgcagga acccgaacag ttccccctgg      300

tgcagggagt ggccataggt ggctcctatg gacggaaaac agtcttaaga ggcaactccg      360

atggtaccct tgtcctcttc ttcagtgact taaaacaatt ccaggatcag aagagaagcc      420

aacgtgacat cctcgataaa actggggata agctgaagtt ctgtctgttc acgaagtggt      480

tgaaaaacaa tttcgagatc cagaagtccc ttgatgggtt caccatccag gtgttcacaa      540

aaaatcagag aatctctttc gaggtgctgg ccgccttcaa cgctctgagt aagcattgct      600

gggtgtcagg agagaaaagc caaagaagcg ggtgccagac agctctgtgc aacctctagg      660

ccatgagtgg gatagatacc actgctgctt taaaaaatgg gagaccatag accctcagga      720

gagaagaatc ccttctaccc tggactcgct ctcttctctg gaactaactt ctcccccata      780

ccctgattgt ctttggagaa aatgttctgg attctagaat ctaaggcaga gccttttaag      840

ccatactgta cacataaatc acctggaacc ttgttaaaat gcagatcctg actcaggagg      900

tctgagttag agcccaggat ttcatatttc tagccagctc catgatgagc tgctggtccg      960

cagatcatgc ttgcaggttt tgaccagagt cagtgttggt tagagtaaga ggatgaggca     1020

gacatctggg aaaagtccag ctggggcaag catttgaagt ctgccttcct accaggtcaa     1080

aatcaaggca acgaccttcc atagataact atcaaagctt gagggggtgc cttgaaccca     1140

actcctaaat ccctaagacc tgcccacctc ttgtgtctcc tgtctcagca aacattccca     1200

cactcttgca tattgttaaa gtaacctctg cttaccaggc ttctggttta ataaaagatg     1260

gctagagtga ctccatctta aagcaagtag ctaggcactc aaaaggaacc tacaggctta     1320

atacttgggt ctgaaaatag ccacagtcta agctgaccac caattataat tgcagaatat     1380

ttaaggccat acaaaacatc tcccactaag cctacaaaat gtccaggtgt cctaaaagtt     1440

cagcccactt aaaggcagca ttaatgagca ggtttaggtt gaaggattaa tggtcatcaa     1500

taccactgtt aagaagaaaa ttcttggcca aattgaattt aatggagttt aactgagcag     1560

acaattcaca aatctagaag cctcctgagc cagagtaggt tcagagagtc ttgaacacag     1620

ccacgtggtg gaagaagatt tatggacagg aaaaggaaaa tgatgtactg aaaatgaaag     1680

tgaggtacag aaacagccag actggttata gctcagcatt ggccttattt gaacgagatt     1740

tgaacagttg gccacctttg attggccgaa actcagtgat tggcacaaga gtaggttgca     1800

gtctgtttac acatcctttt aggttatagt tcaccatgta cagagaaatt ttaggccaaa     1860

cttaaaatat gtaaggaggc agctttaggc taaacttgat ttaacagcac caataccccc     1920

tacctttagt gagcacatct gcacattcca attttaatga cagctcctta gaatttctta     1980

tcaacgaaga cactaacaaa gaatggcgca ttcctccttc tcctttctga ggatgcccta     2040

ccctgtaaca aagtcgtttc taataaattt gcttctttca ccataaaaaa aaaaaaaaaa     2100

aaaaaaaaaa aaaaaaaaaa aaa                                             2123


<210>  36
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Asn Gly Glu Ser Gln Leu Ser Ser Val Pro Ala Gln Lys Leu 
1               5                   10                  15      


Gly Trp Phe Ile Gln Glu Tyr Leu Lys Pro Tyr Glu Glu Cys Gln Thr 
            20                  25                  30          


Leu Ile Asp Glu Met Val Asn Thr Ile Cys Asp Val Leu Gln Glu Pro 
        35                  40                  45              


Glu Gln Phe Pro Leu Val Gln Gly Val Ala Ile Gly Gly Ser Tyr Gly 
    50                  55                  60                  


Arg Lys Thr Val Leu Arg Gly Asn Ser Asp Gly Thr Leu Val Leu Phe 
65                  70                  75                  80  


Phe Ser Asp Leu Lys Gln Phe Gln Asp Gln Lys Arg Ser Gln Arg Asp 
                85                  90                  95      


Ile Leu Asp Lys Thr Gly Asp Lys Leu Lys Phe Cys Leu Phe Thr Lys 
            100                 105                 110         


Trp Leu Lys Asn Asn Phe Glu Ile Gln Lys Ser Leu Asp Gly Phe Thr 
        115                 120                 125             


Ile Gln Val Phe Thr Lys Asn Gln Arg Ile Ser Phe Glu Val Leu Ala 
    130                 135                 140                 


Ala Phe Asn Ala Leu Ser Leu Asn Asp Asn Pro Ser Pro Trp Ile Tyr 
145                 150                 155                 160 


Arg Glu Leu Lys Arg Ser Leu Asp Lys Thr Asn Ala Ser Pro Gly Glu 
                165                 170                 175     


Phe Ala Val Cys Phe Thr Glu Leu Gln Gln Lys Phe Phe Asp Asn Arg 
            180                 185                 190         


Pro Gly Lys Leu Lys Asp Leu Ile Leu Leu Ile Lys His Trp His Gln 
        195                 200                 205             


Gln Cys Gln Lys Lys Ile Lys Asp Leu Pro Ser Leu Ser Pro Tyr Ala 
    210                 215                 220                 


Leu Glu Leu Leu Thr Val Tyr Ala Trp Glu Gln Gly Cys Arg Lys Asp 
225                 230                 235                 240 


Asn Phe Asp Ile Ala Glu Gly Val Arg Thr Val Leu Glu Leu Ile Lys 
                245                 250                 255     


Cys Gln Glu Lys Leu Cys Ile Tyr Trp Met Val Asn Tyr Asn Phe Glu 
            260                 265                 270         


Asp Glu Thr Ile Arg Asn Ile Leu Leu His Gln Leu Gln Ser Ala Arg 
        275                 280                 285             


Pro Val Ile Leu Asp Pro Val Asp Pro Thr Asn Asn Val Ser Gly Asp 
    290                 295                 300                 


Lys Ile Cys Trp Gln Trp Leu Lys Lys Glu Ala Gln Thr Trp Leu Thr 
305                 310                 315                 320 


Ser Pro Asn Leu Asp Asn Glu Leu Pro Ala Pro Ser Trp Asn Val Leu 
                325                 330                 335     


Pro Ala Pro Leu Phe Thr Thr Pro Gly His Leu Leu Asp Lys Phe Ile 
            340                 345                 350         


Lys Glu Phe Leu Gln Pro Asn Lys Cys Phe Leu Glu Gln Ile Asp Ser 
        355                 360                 365             


Ala Val Asn Ile Ile Arg Thr Phe Leu Lys Glu Asn Cys Phe Arg Gln 
    370                 375                 380                 


Ser Thr Ala Lys Ile Gln Ile Val Arg Gly Gly Ser Thr Ala Lys Gly 
385                 390                 395                 400 


Thr Ala Leu Lys Thr Gly Ser Asp Ala Asp Leu Val Val Phe His Asn 
                405                 410                 415     


Ser Leu Lys Ser Tyr Thr Ser Gln Lys Asn Glu Arg His Lys Ile Val 
            420                 425                 430         


Lys Glu Ile His Glu Gln Leu Lys Ala Phe Trp Arg Glu Lys Glu Glu 
        435                 440                 445             


Glu Leu Glu Val Ser Phe Glu Pro Pro Lys Trp Lys Ala Pro Arg Val 
    450                 455                 460                 


Leu Ser Phe Ser Leu Lys Ser Lys Val Leu Asn Glu Ser Val Ser Phe 
465                 470                 475                 480 


Asp Val Leu Pro Ala Phe Asn Ala Leu Gly Gln Leu Ser Ser Gly Ser 
                485                 490                 495     


Thr Pro Ser Pro Glu Val Tyr Ala Gly Leu Ile Asp Leu Tyr Lys Ser 
            500                 505                 510         


Ser Asp Leu Pro Gly Gly Glu Phe Ser Thr Cys Phe Thr Val Leu Gln 
        515                 520                 525             


Arg Asn Phe Ile Arg Ser Arg Pro Thr Lys Leu Lys Asp Leu Ile Arg 
    530                 535                 540                 


Leu Val Lys His Trp Tyr Lys Glu Cys Glu Arg Lys Leu Lys Pro Lys 
545                 550                 555                 560 


Gly Ser Leu Pro Pro Lys Tyr Ala Leu Glu Leu Leu Thr Ile Tyr Ala 
                565                 570                 575     


Trp Glu Gln Gly Ser Gly Val Pro Asp Phe Asp Thr Ala Glu Gly Phe 
            580                 585                 590         


Arg Thr Val Leu Glu Leu Val Thr Gln Tyr Gln Gln Leu Cys Ile Phe 
        595                 600                 605             


Trp Lys Val Asn Tyr Asn Phe Glu Asp Glu Thr Val Arg Lys Phe Leu 
    610                 615                 620                 


Leu Ser Gln Leu Gln Lys Thr Arg Pro Val Ile Leu Asp Pro Ala Glu 
625                 630                 635                 640 


Pro Thr Gly Asp Val Gly Gly Gly Asp Arg Trp Cys Trp His Leu Leu 
                645                 650                 655     


Ala Lys Glu Ala Lys Glu Trp Leu Ser Ser Pro Cys Phe Lys Asp Gly 
            660                 665                 670         


Thr Gly Asn Pro Ile Pro Pro Trp Lys Val Pro Thr Met Gln Thr Pro 
        675                 680                 685             


Gly Ser Cys Gly Ala Arg Ile His Pro Ile Val Asn Glu Met Phe Ser 
    690                 695                 700                 


Ser Arg Ser His Arg Ile Leu Asn Asn Asn Ser Lys Arg Asn Phe 
705                 710                 715                 


<210>  37
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Asn Gly Glu Ser Gln Leu Ser Ser Val Pro Ala Gln Lys Leu 
1               5                   10                  15      


Gly Trp Phe Ile Gln Glu Tyr Leu Lys Pro Tyr Glu Glu Cys Gln Thr 
            20                  25                  30          


Leu Ile Asp Glu Met Val Asn Thr Ile Cys Asp Val Leu Gln Glu Pro 
        35                  40                  45              


Glu Gln Phe Pro Leu Val Gln Gly Val Ala Ile Gly Gly Ser Tyr Gly 
    50                  55                  60                  


Arg Lys Thr Val Leu Arg Gly Asn Ser Asp Gly Thr Leu Val Leu Phe 
65                  70                  75                  80  


Phe Ser Asp Leu Lys Gln Phe Gln Asp Gln Lys Arg Ser Gln Arg Asp 
                85                  90                  95      


Ile Leu Asp Lys Thr Gly Asp Lys Leu Lys Phe Cys Leu Phe Thr Lys 
            100                 105                 110         


Trp Leu Lys Asn Asn Phe Glu Ile Gln Lys Ser Leu Asp Gly Phe Thr 
        115                 120                 125             


Ile Gln Val Phe Thr Lys Asn Gln Arg Ile Ser Phe Glu Val Leu Ala 
    130                 135                 140                 


Ala Phe Asn Ala Leu Ser Leu Asn Asp Asn Pro Ser Pro Trp Ile Tyr 
145                 150                 155                 160 


Arg Glu Leu Lys Arg Ser Leu Asp Lys Thr Asn Ala Ser Pro Gly Glu 
                165                 170                 175     


Phe Ala Val Cys Phe Thr Glu Leu Gln Gln Lys Phe Phe Asp Asn Arg 
            180                 185                 190         


Pro Gly Lys Leu Lys Asp Leu Ile Leu Leu Ile Lys His Trp His Gln 
        195                 200                 205             


Gln Cys Gln Lys Lys Ile Lys Asp Leu Pro Ser Leu Ser Pro Tyr Ala 
    210                 215                 220                 


Leu Glu Leu Leu Thr Val Tyr Ala Trp Glu Gln Gly Cys Arg Lys Asp 
225                 230                 235                 240 


Asn Phe Asp Ile Ala Glu Gly Val Arg Thr Val Leu Glu Leu Ile Lys 
                245                 250                 255     


Cys Gln Glu Lys Leu Cys Ile Tyr Trp Met Val Asn Tyr Asn Phe Glu 
            260                 265                 270         


Asp Glu Thr Ile Arg Asn Ile Leu Leu His Gln Leu Gln Ser Ala Arg 
        275                 280                 285             


Pro Val Ile Leu Asp Pro Val Asp Pro Thr Asn Asn Val Ser Gly Asp 
    290                 295                 300                 


Lys Ile Cys Trp Gln Trp Leu Lys Lys Glu Ala Gln Thr Trp Leu Thr 
305                 310                 315                 320 


Ser Pro Asn Leu Asp Asn Glu Leu Pro Ala Pro Ser Trp Asn Val Leu 
                325                 330                 335     


Pro Ala Pro Leu Phe Thr Thr Pro Gly His Leu Leu Asp Lys Phe Ile 
            340                 345                 350         


Lys Glu Phe Leu Gln Pro Asn Lys Cys Phe Leu Glu Gln Ile Asp Ser 
        355                 360                 365             


Ala Val Asn Ile Ile Arg Thr Phe Leu Lys Glu Asn Cys Phe Arg Gln 
    370                 375                 380                 


Ser Thr Ala Lys Ile Gln Ile Val Arg Gly Gly Ser Thr Ala Lys Gly 
385                 390                 395                 400 


Thr Ala Leu Lys Thr Gly Ser Asp Ala Asp Leu Val Val Phe His Asn 
                405                 410                 415     


Ser Leu Lys Ser Tyr Thr Ser Gln Lys Asn Glu Arg His Lys Ile Val 
            420                 425                 430         


Lys Glu Ile His Glu Gln Leu Lys Ala Phe Trp Arg Glu Lys Glu Glu 
        435                 440                 445             


Glu Leu Glu Val Ser Phe Glu Pro Pro Lys Trp Lys Ala Pro Arg Val 
    450                 455                 460                 


Leu Ser Phe Ser Leu Lys Ser Lys Val Leu Asn Glu Ser Val Ser Phe 
465                 470                 475                 480 


Asp Val Leu Pro Ala Phe Asn Ala Leu Gly Gln Leu Ser Ser Gly Ser 
                485                 490                 495     


Thr Pro Ser Pro Glu Val Tyr Ala Gly Leu Ile Asp Leu Tyr Lys Ser 
            500                 505                 510         


Ser Asp Leu Pro Gly Gly Glu Phe Ser Thr Cys Phe Thr Val Leu Gln 
        515                 520                 525             


Arg Asn Phe Ile Arg Ser Arg Pro Thr Lys Leu Lys Asp Leu Ile Arg 
    530                 535                 540                 


Leu Val Lys His Trp Tyr Lys Glu Cys Glu Arg Lys Leu Lys Pro Lys 
545                 550                 555                 560 


Gly Ser Leu Pro Pro Lys Tyr Ala Leu Glu Leu Leu Thr Ile Tyr Ala 
                565                 570                 575     


Trp Glu Gln Gly Ser Gly Val Pro Asp Phe Asp Thr Ala Glu Gly Phe 
            580                 585                 590         


Arg Thr Val Leu Glu Leu Val Thr Gln Tyr Gln Gln Leu Cys Ile Phe 
        595                 600                 605             


Trp Lys Val Asn Tyr Asn Phe Glu Asp Glu Thr Val Arg Lys Phe Leu 
    610                 615                 620                 


Leu Ser Gln Leu Gln Lys Thr Arg Pro Val Ile Leu Asp Pro Ala Glu 
625                 630                 635                 640 


Pro Thr Gly Asp Val Gly Gly Gly Asp Arg Trp Cys Trp His Leu Leu 
                645                 650                 655     


Ala Lys Glu Ala Lys Glu Trp Leu Ser Ser Pro Cys Phe Lys Asp Gly 
            660                 665                 670         


Thr Gly Asn Pro Ile Pro Pro Trp Lys Val Pro Val Lys Val Ile 
        675                 680                 685         


<210>  38
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gly Asn Gly Glu Ser Gln Leu Ser Ser Val Pro Ala Gln Lys Leu 
1               5                   10                  15      


Gly Trp Phe Ile Gln Glu Tyr Leu Lys Pro Tyr Glu Glu Cys Gln Thr 
            20                  25                  30          


Leu Ile Asp Glu Met Val Asn Thr Ile Cys Asp Val Leu Gln Glu Pro 
        35                  40                  45              


Glu Gln Phe Pro Leu Val Gln Gly Val Ala Ile Gly Gly Ser Tyr Gly 
    50                  55                  60                  


Arg Lys Thr Val Leu Arg Gly Asn Ser Asp Gly Thr Leu Val Leu Phe 
65                  70                  75                  80  


Phe Ser Asp Leu Lys Gln Phe Gln Asp Gln Lys Arg Ser Gln Arg Asp 
                85                  90                  95      


Ile Leu Asp Lys Thr Gly Asp Lys Leu Lys Phe Cys Leu Phe Thr Lys 
            100                 105                 110         


Trp Leu Lys Asn Asn Phe Glu Ile Gln Lys Ser Leu Asp Gly Phe Thr 
        115                 120                 125             


Ile Gln Val Phe Thr Lys Asn Gln Arg Ile Ser Phe Glu Val Leu Ala 
    130                 135                 140                 


Ala Phe Asn Ala Leu Ser Lys His Cys Trp Val Ser Gly Glu Lys Ser 
145                 150                 155                 160 


Gln Arg Ser Gly Cys Gln Thr Ala Leu Cys Asn Leu 
                165                 170         


<210>  39
<211>  3520
<212>  DNA
<213>  Homo sapiens

<400>  39
tcagtagctg aggctgcggt tccccgacgc cacgcagctg cgcgcagctg gttcccgctc       60

tgcagcgcaa cgcctgaggc agtgggcgcg ctcagtcccg ggaccaggcg ttctctcctc      120

tcgcctctgg gcctgggacc ccgcaaagcg gcgatggagc ggaggtcgcg gaggaagtcg      180

cggcgcaacg ggcgctcgac cgcgggcaag gccgccgcga cccagcccgc gaagtctccg      240

ggcgcacagc tctggctctt tcccagcgcc gcgggcctcc accgcgcgct gctccggagg      300

gtggaggtga cgcgccaact ctgctgctcg ccggggcgcc tcgcggtctt ggaacgcggc      360

ggggcgggcg tccaggttca ccagctgctc gccgggagcg gcggcgcccg gacgccgaaa      420

tgcattaaat taggaaaaaa catgaagata cattccgtgg accaaggagc agagcacatg      480

ctgattctct catcagatgg aaaaccattt gagtatgaca actatagcat gaaacatcta      540

aggtttgaaa gcattttaca agaaaaaaaa ataattcaga tcacatgtgg agattaccat      600

tctcttgcac tctcaaaagg tggtgagctt tttgcctggg gacagaacct gcatgggcag      660

cttggagttg gaaggaaatt tccctcaacc accacaccac agattgtgga gcacctcgca      720

ggagtaccct tggctcagat ttctgccgga gaagcccaca gcatggcctt atccatgtct      780

ggcaacattt attcatgggg aaaaaatgaa tgtggacaac taggcctggg ccacactgag      840

agtaaagatg atccatccct tattgaagga ctagacaatc agaaagttga atttgtcgct      900

tgtggtggct ctcacagtgc cctactcaca caggatgggc tgctgtttac tttcggtgct      960

ggaaaacatg ggcaacttgg tcataattca acacagaatg agctaagacc ctgtttggtg     1020

gctgagcttg ttgggtatag agtgactcag atagcatgtg gaaggtggca cacacttgcc     1080

tatgtttctg atttgggaaa ggtcttttcc tttggttctg gaaaagatgg acaactggga     1140

aatggtggaa cacgtgacca gctgatgccg cttccagtga aagtatcatc aagtgaagaa     1200

ctcaaacttg aaagccatac ctcagaaaag gagttaataa tgattgctgg agggaatcaa     1260

agcattttgc tctggataaa gaaagagaat tcatatgtta atctgaagag gacaattcct     1320

actctgaatg aagggactgt aaagagatgg attgctgatg tggagactaa acggtggcag     1380

agcacaaaaa gggaaatcca agagatattt tcatctcctg cttgtctaac tggaagtttt     1440

ttaaggaaaa gaagaactac agaaatgatg cctgtttatt tggacttaaa taaagcaaga     1500

aacatcttca aggagttaac ccaaaaggac tggattacta acatgataac cacctgcctc     1560

aaagataatc tgctcaaaag acttccattt cattctccac cccaagaagc tttagaaatt     1620

ttcttccttc tcccagaatg tcctatgatg catatttcca acaactggga gagccttgtg     1680

gttccatttg caaaggttgt ttgtaaaatg agtgaccagt cttcactggt tctggaagag     1740

tattgggcaa ctctgcaaga atccactttc agcaaactgg tccagatgtt taaaacagcc     1800

gtcatatgcc agttggatta ctgggatgaa agtgctgagg agaatggtaa tgttcaagct     1860

ctcctagaaa tgttgaagaa gctgcacagg gtaaaccagg tgaaatgtca actacctgaa     1920

agtattttcc aagtagacga actcttgcac cgtctcaatt tttttgtaga agtatgcaga     1980

aggtacttgt ggaaaatgac tgtggacgct tcagaaaatg tacaatgctg cgtcatattc     2040

agtcactttc catttatctt taataatctg tcgaaaatta aactactaca tacagacaca     2100

cttttaaaaa tagagagtaa aaaacataaa gcttatctta ggtcggcagc aattgaggaa     2160

gaaagagagt ctgaattcgc tttgaggccc acgtttgatc taacagtcag aaggaatcac     2220

ttgattgagg atgttttgaa tcagctaagt caatttgaga atgaagacct gaggaaagag     2280

ttatgggttt catttagtgg agaaattggg tatgacctcg gaggagtcaa gaaagagttc     2340

ttctactgtc tgtttgcaga gatgatccag ccggaatatg ggatgttcat gtatcctgaa     2400

ggggcttcct gcatgtggtt tcctgtcaag cctaaatttg agaagaaaag atacttcttt     2460

tttggggttc tatgtggact ttccctgttc aattgcaatg ttgccaacct tcctttccca     2520

ctggcactgt ttaagaaact tttggaccaa atgccatcat tggaagactt gaaagaactc     2580

agtcctgatt tgggaaagaa tttgcaaaca cttctggatg atgaaggtga taactttgag     2640

gaagtatttt acatccattt taatgtgcac tgggacagaa acgacacaaa cttaattcct     2700

aatggaagta gcataactgt caaccagact aacaagagag actatgtttc taagtatatc     2760

aattacattt tcaacgactc tgtaaaggcg gtttatgaag aatttcggag aggattttat     2820

aaaatgtgcg acgaagacat tatcaaatta ttccaccccg aagaactgaa ggatgtgatt     2880

gttggaaata cagattatga ttggaaaaca tttgaaaaga atgcacgtta tgaaccagga     2940

tataacagtt cacatcccac catagtgatg ttttggaagg ctttccacaa attgactctg     3000

gaagaaaaga aaaaattcct tgtatttctt acaggaactg acagactaca aatgaaagat     3060

ttaaataata tgaaaataac attttgctgt cctgaaagtt ggaatgaaag agaccctata     3120

agagcactga catgtttcag tgtcctcttc ctccctaaat attctacaat ggaaacagtt     3180

gaagaagcgc ttcaagaagc catcaacaac aacagaggat ttggctgacc agcttgcttg     3240

tccaacagcc ttattttgtt gttgttatcg ttgttgttgt tgttgttgtt gttgtttctc     3300

tactttgttt tgttttaggc ttttagcagc ctgaagccat ggtttttcat ttctgtctct     3360

agtgataagc aggaaagagg gatgaagaag agggtttact ggccggttag aacccgtgac     3420

tgtattctct cccttggata cccctatgcc tacatcatat tccttacctc ttttgggaaa     3480

tatttttcaa aaataaaata accgaaaaat taacataaaa                           3520


<210>  40
<211>  1024
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Glu Arg Arg Ser Arg Arg Lys Ser Arg Arg Asn Gly Arg Ser Thr 
1               5                   10                  15      


Ala Gly Lys Ala Ala Ala Thr Gln Pro Ala Lys Ser Pro Gly Ala Gln 
            20                  25                  30          


Leu Trp Leu Phe Pro Ser Ala Ala Gly Leu His Arg Ala Leu Leu Arg 
        35                  40                  45              


Arg Val Glu Val Thr Arg Gln Leu Cys Cys Ser Pro Gly Arg Leu Ala 
    50                  55                  60                  


Val Leu Glu Arg Gly Gly Ala Gly Val Gln Val His Gln Leu Leu Ala 
65                  70                  75                  80  


Gly Ser Gly Gly Ala Arg Thr Pro Lys Cys Ile Lys Leu Gly Lys Asn 
                85                  90                  95      


Met Lys Ile His Ser Val Asp Gln Gly Ala Glu His Met Leu Ile Leu 
            100                 105                 110         


Ser Ser Asp Gly Lys Pro Phe Glu Tyr Asp Asn Tyr Ser Met Lys His 
        115                 120                 125             


Leu Arg Phe Glu Ser Ile Leu Gln Glu Lys Lys Ile Ile Gln Ile Thr 
    130                 135                 140                 


Cys Gly Asp Tyr His Ser Leu Ala Leu Ser Lys Gly Gly Glu Leu Phe 
145                 150                 155                 160 


Ala Trp Gly Gln Asn Leu His Gly Gln Leu Gly Val Gly Arg Lys Phe 
                165                 170                 175     


Pro Ser Thr Thr Thr Pro Gln Ile Val Glu His Leu Ala Gly Val Pro 
            180                 185                 190         


Leu Ala Gln Ile Ser Ala Gly Glu Ala His Ser Met Ala Leu Ser Met 
        195                 200                 205             


Ser Gly Asn Ile Tyr Ser Trp Gly Lys Asn Glu Cys Gly Gln Leu Gly 
    210                 215                 220                 


Leu Gly His Thr Glu Ser Lys Asp Asp Pro Ser Leu Ile Glu Gly Leu 
225                 230                 235                 240 


Asp Asn Gln Lys Val Glu Phe Val Ala Cys Gly Gly Ser His Ser Ala 
                245                 250                 255     


Leu Leu Thr Gln Asp Gly Leu Leu Phe Thr Phe Gly Ala Gly Lys His 
            260                 265                 270         


Gly Gln Leu Gly His Asn Ser Thr Gln Asn Glu Leu Arg Pro Cys Leu 
        275                 280                 285             


Val Ala Glu Leu Val Gly Tyr Arg Val Thr Gln Ile Ala Cys Gly Arg 
    290                 295                 300                 


Trp His Thr Leu Ala Tyr Val Ser Asp Leu Gly Lys Val Phe Ser Phe 
305                 310                 315                 320 


Gly Ser Gly Lys Asp Gly Gln Leu Gly Asn Gly Gly Thr Arg Asp Gln 
                325                 330                 335     


Leu Met Pro Leu Pro Val Lys Val Ser Ser Ser Glu Glu Leu Lys Leu 
            340                 345                 350         


Glu Ser His Thr Ser Glu Lys Glu Leu Ile Met Ile Ala Gly Gly Asn 
        355                 360                 365             


Gln Ser Ile Leu Leu Trp Ile Lys Lys Glu Asn Ser Tyr Val Asn Leu 
    370                 375                 380                 


Lys Arg Thr Ile Pro Thr Leu Asn Glu Gly Thr Val Lys Arg Trp Ile 
385                 390                 395                 400 


Ala Asp Val Glu Thr Lys Arg Trp Gln Ser Thr Lys Arg Glu Ile Gln 
                405                 410                 415     


Glu Ile Phe Ser Ser Pro Ala Cys Leu Thr Gly Ser Phe Leu Arg Lys 
            420                 425                 430         


Arg Arg Thr Thr Glu Met Met Pro Val Tyr Leu Asp Leu Asn Lys Ala 
        435                 440                 445             


Arg Asn Ile Phe Lys Glu Leu Thr Gln Lys Asp Trp Ile Thr Asn Met 
    450                 455                 460                 


Ile Thr Thr Cys Leu Lys Asp Asn Leu Leu Lys Arg Leu Pro Phe His 
465                 470                 475                 480 


Ser Pro Pro Gln Glu Ala Leu Glu Ile Phe Phe Leu Leu Pro Glu Cys 
                485                 490                 495     


Pro Met Met His Ile Ser Asn Asn Trp Glu Ser Leu Val Val Pro Phe 
            500                 505                 510         


Ala Lys Val Val Cys Lys Met Ser Asp Gln Ser Ser Leu Val Leu Glu 
        515                 520                 525             


Glu Tyr Trp Ala Thr Leu Gln Glu Ser Thr Phe Ser Lys Leu Val Gln 
    530                 535                 540                 


Met Phe Lys Thr Ala Val Ile Cys Gln Leu Asp Tyr Trp Asp Glu Ser 
545                 550                 555                 560 


Ala Glu Glu Asn Gly Asn Val Gln Ala Leu Leu Glu Met Leu Lys Lys 
                565                 570                 575     


Leu His Arg Val Asn Gln Val Lys Cys Gln Leu Pro Glu Ser Ile Phe 
            580                 585                 590         


Gln Val Asp Glu Leu Leu His Arg Leu Asn Phe Phe Val Glu Val Cys 
        595                 600                 605             


Arg Arg Tyr Leu Trp Lys Met Thr Val Asp Ala Ser Glu Asn Val Gln 
    610                 615                 620                 


Cys Cys Val Ile Phe Ser His Phe Pro Phe Ile Phe Asn Asn Leu Ser 
625                 630                 635                 640 


Lys Ile Lys Leu Leu His Thr Asp Thr Leu Leu Lys Ile Glu Ser Lys 
                645                 650                 655     


Lys His Lys Ala Tyr Leu Arg Ser Ala Ala Ile Glu Glu Glu Arg Glu 
            660                 665                 670         


Ser Glu Phe Ala Leu Arg Pro Thr Phe Asp Leu Thr Val Arg Arg Asn 
        675                 680                 685             


His Leu Ile Glu Asp Val Leu Asn Gln Leu Ser Gln Phe Glu Asn Glu 
    690                 695                 700                 


Asp Leu Arg Lys Glu Leu Trp Val Ser Phe Ser Gly Glu Ile Gly Tyr 
705                 710                 715                 720 


Asp Leu Gly Gly Val Lys Lys Glu Phe Phe Tyr Cys Leu Phe Ala Glu 
                725                 730                 735     


Met Ile Gln Pro Glu Tyr Gly Met Phe Met Tyr Pro Glu Gly Ala Ser 
            740                 745                 750         


Cys Met Trp Phe Pro Val Lys Pro Lys Phe Glu Lys Lys Arg Tyr Phe 
        755                 760                 765             


Phe Phe Gly Val Leu Cys Gly Leu Ser Leu Phe Asn Cys Asn Val Ala 
    770                 775                 780                 


Asn Leu Pro Phe Pro Leu Ala Leu Phe Lys Lys Leu Leu Asp Gln Met 
785                 790                 795                 800 


Pro Ser Leu Glu Asp Leu Lys Glu Leu Ser Pro Asp Leu Gly Lys Asn 
                805                 810                 815     


Leu Gln Thr Leu Leu Asp Asp Glu Gly Asp Asn Phe Glu Glu Val Phe 
            820                 825                 830         


Tyr Ile His Phe Asn Val His Trp Asp Arg Asn Asp Thr Asn Leu Ile 
        835                 840                 845             


Pro Asn Gly Ser Ser Ile Thr Val Asn Gln Thr Asn Lys Arg Asp Tyr 
    850                 855                 860                 


Val Ser Lys Tyr Ile Asn Tyr Ile Phe Asn Asp Ser Val Lys Ala Val 
865                 870                 875                 880 


Tyr Glu Glu Phe Arg Arg Gly Phe Tyr Lys Met Cys Asp Glu Asp Ile 
                885                 890                 895     


Ile Lys Leu Phe His Pro Glu Glu Leu Lys Asp Val Ile Val Gly Asn 
            900                 905                 910         


Thr Asp Tyr Asp Trp Lys Thr Phe Glu Lys Asn Ala Arg Tyr Glu Pro 
        915                 920                 925             


Gly Tyr Asn Ser Ser His Pro Thr Ile Val Met Phe Trp Lys Ala Phe 
    930                 935                 940                 


His Lys Leu Thr Leu Glu Glu Lys Lys Lys Phe Leu Val Phe Leu Thr 
945                 950                 955                 960 


Gly Thr Asp Arg Leu Gln Met Lys Asp Leu Asn Asn Met Lys Ile Thr 
                965                 970                 975     


Phe Cys Cys Pro Glu Ser Trp Asn Glu Arg Asp Pro Ile Arg Ala Leu 
            980                 985                 990         


Thr Cys Phe Ser Val Leu Phe Leu  Pro Lys Tyr Ser Thr  Met Glu Thr 
        995                 1000                 1005             


Val Glu  Glu Ala Leu Gln Glu  Ala Ile Asn Asn Asn  Arg Gly Phe 
    1010                 1015                 1020             


Gly 
    


<210>  41
<211>  2037
<212>  DNA
<213>  Homo sapiens

<400>  41
gggaagctcg ggccggcagg gtttccccgc acgctggcgc ccagctcccg gcgcggaggc       60

cgctgtaagt ttcgctttcc attcagtgga aaacgaaagc tgggcggggt gccacgagcg      120

cggggccaga ccaaggcggg cccggagcgg aacttcggtc ccagctcggt ccccggctca      180

gtcccgacgt ggaactcagc agcggaggct ggacgcttgc atggcgcttg agagattcca      240

tcgtgcctgg ctcacataag cgcttcctgg aagtgaagtc gtgctgtcct gaacgcgggc      300

caggcagctg cggcctgggg gttttggagt gatcacgaat gagcaaggcg tttgggctcc      360

tgaggcaaat ctgtcagtcc atcctggctg agtcctcgca gtccccggca gatcttgaag      420

aaaagaagga agaagacagc aacatgaaga gagagcagcc cagagagcgt cccagggcct      480

gggactaccc tcatggcctg gttggtttac acaacattgg acagacctgc tgccttaact      540

ccttgattca ggtgttcgta atgaatgtgg acttcaccag gatattgaag aggatcacgg      600

tgcccagggg agctgacgag cagaggagaa gcgtcccttt ccagatgctt ctgctgctgg      660

agaagatgca ggacagccgg cagaaagcag tgcggcccct ggagctggcc tactgcctgc      720

agaagtgcaa cgtgcccttg tttgtccaac atgatgctgc ccaactgtac ctcaaactct      780

ggaacctgat taaggaccag atcactgatg tgcacttggt ggagagactg caggccctgt      840

atacgatccg ggtgaaggac tccttgattt gcgttgactg tgccatggag agtagcagaa      900

acagcagcat gctcaccctc ccactttctc tttttgatgt ggactcaaag cccctgaaga      960

cactggagga cgccctgcac tgcttcttcc agcccaggga gttatcaagc aaaagcaagt     1020

gcttctgtga gaactgtggg aagaagaccc gtgggaaaca ggtcttgaag ctgacccatt     1080

tgccccagac cctgacaatc cacctcatgc gattctccat caggaattca cagacgagaa     1140

agatctgcca ctccctgtac ttcccccaga gcttggattt cagccagatc cttccaatga     1200

agcgagagtc ttgtgatgct gaggagcagt ctggagggca gtatgagctt tttgctgtga     1260

ttgcgcacgt gggaatggca gactccggtc attactgtgt ctacatccgg aatgctgtgg     1320

atggaaaatg gttctgcttc aatgactcca atatttgctt ggtgtcctgg gaagacatcc     1380

agtgtaccta cggaaatcct aactaccact ggcaggaaac tgcatatctt ctggtttaca     1440

tgaagatgga gtgctaatgg aaatgcccaa aaccttcaga gattgacacg ctgtcatttt     1500

ccatttccgt tcctggatct acggagtctt ctaagagatt ttgcaatgag gagaagcatt     1560

gttttcaaac tatataactg agccttattt ataattaggg atattatcaa aatatgtaac     1620

catgaggccc ctcaggtcct gatcagtcag aatggatgct ttcaccagca gacccggcca     1680

tgtggctgct cggtcctggg tgctcgctgc tgtgcaagac attagccctt tagttatgag     1740

cctgtgggaa cttcaggggt tcccagtggg gagagcagtg gcagtgggag gcatctgggg     1800

gccaaaggtc agtggcaggg ggtatttcag tattatacaa ctgctgtgac cagacttgta     1860

tactggctga atatcagtgc tgtttgtaat ttttcacttt gagaaccaac attaattcca     1920

tatgaatcaa gtgttttgta actgctattc atttattcag caaatattta ttgatcatct     1980

cttctccata agatagtgtg ataaacacag tcatgaataa agttattttc cacaaaa        2037


<210>  42
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Lys Ala Phe Gly Leu Leu Arg Gln Ile Cys Gln Ser Ile Leu 
1               5                   10                  15      


Ala Glu Ser Ser Gln Ser Pro Ala Asp Leu Glu Glu Lys Lys Glu Glu 
            20                  25                  30          


Asp Ser Asn Met Lys Arg Glu Gln Pro Arg Glu Arg Pro Arg Ala Trp 
        35                  40                  45              


Asp Tyr Pro His Gly Leu Val Gly Leu His Asn Ile Gly Gln Thr Cys 
    50                  55                  60                  


Cys Leu Asn Ser Leu Ile Gln Val Phe Val Met Asn Val Asp Phe Thr 
65                  70                  75                  80  


Arg Ile Leu Lys Arg Ile Thr Val Pro Arg Gly Ala Asp Glu Gln Arg 
                85                  90                  95      


Arg Ser Val Pro Phe Gln Met Leu Leu Leu Leu Glu Lys Met Gln Asp 
            100                 105                 110         


Ser Arg Gln Lys Ala Val Arg Pro Leu Glu Leu Ala Tyr Cys Leu Gln 
        115                 120                 125             


Lys Cys Asn Val Pro Leu Phe Val Gln His Asp Ala Ala Gln Leu Tyr 
    130                 135                 140                 


Leu Lys Leu Trp Asn Leu Ile Lys Asp Gln Ile Thr Asp Val His Leu 
145                 150                 155                 160 


Val Glu Arg Leu Gln Ala Leu Tyr Thr Ile Arg Val Lys Asp Ser Leu 
                165                 170                 175     


Ile Cys Val Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu 
            180                 185                 190         


Thr Leu Pro Leu Ser Leu Phe Asp Val Asp Ser Lys Pro Leu Lys Thr 
        195                 200                 205             


Leu Glu Asp Ala Leu His Cys Phe Phe Gln Pro Arg Glu Leu Ser Ser 
    210                 215                 220                 


Lys Ser Lys Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys 
225                 230                 235                 240 


Gln Val Leu Lys Leu Thr His Leu Pro Gln Thr Leu Thr Ile His Leu 
                245                 250                 255     


Met Arg Phe Ser Ile Arg Asn Ser Gln Thr Arg Lys Ile Cys His Ser 
            260                 265                 270         


Leu Tyr Phe Pro Gln Ser Leu Asp Phe Ser Gln Ile Leu Pro Met Lys 
        275                 280                 285             


Arg Glu Ser Cys Asp Ala Glu Glu Gln Ser Gly Gly Gln Tyr Glu Leu 
    290                 295                 300                 


Phe Ala Val Ile Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys 
305                 310                 315                 320 


Val Tyr Ile Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp 
                325                 330                 335     


Ser Asn Ile Cys Leu Val Ser Trp Glu Asp Ile Gln Cys Thr Tyr Gly 
            340                 345                 350         


Asn Pro Asn Tyr His Trp Gln Glu Thr Ala Tyr Leu Leu Val Tyr Met 
        355                 360                 365             


Lys Met Glu Cys 
    370         


<210>  43
<211>  1642
<212>  DNA
<213>  Homo sapiens

<400>  43
aagccacggg gagaaacgtt gcagcccgcg ccgaacgccg ggcagcacaa aggatccccg       60

actgccgggg agcggtgctc ggagggcaca ggtctacgcc atcccccacg cagtttcgga      120

gatggagcgc tgggcccatg gagggaaggc ggcaggctcg gcggctccgg cagcttgctg      180

gggcaggggc tcaaggcggc agtccgatag tggaggccgc tgagaactgt cacggagctg      240

cgtctgtaca gcgagcatcc cttatttatt cagggcgagt gtgtatttgg ggcggcgtgc      300

agggggctga caaagaccgg agagctcccg gtgcggccgc cggcggagcg aagactggaa      360

cccgtatgag cgccccccag cgcccctgag cgctcgccgc cggtgcacgg cgcaccccgc      420

gggaggcagg gatcagcaaa gccgtgcgcc ccgaggcccg cccccgtctc cgcacaaaga      480

ccgagctgga ggatcttcag aagaagcctc ccccatacct gcggaacctg tccagcgatg      540

atgccaatgt cctggtgtgg cacgctctcc tcctacccga ccaacctccc taccacctga      600

aagccttcaa cctgcgcatc agcttcccgc cggagtatcc gttcaagcct cccatgatca      660

aattcacaac caagatctac caccccaacg tggacgagaa cggacagatt tgcctgccca      720

tcatcagcag tgagaactgg aagccttgca ccaagacttg ccaagtcctg gaggccctca      780

atgtgctggt gaatagaccg aatatcaggg agcccctgcg gatggacctc gctgacctgc      840

tgacacagaa tccggagctg ttcagaaaga atgccgaaga gttcaccctc cgattcggag      900

tggaccggcc ctcctaactc atgttctgac cctctgtgca ctggatcctc ggcatagcgg      960

acggacacac ctcatggact gaggccagag ccccctgtgg cccattcccc attcattttt     1020

cccttcttag gttgttagtc attagtttgt gtgtgtgtgt ggtggaggga agggagctat     1080

gagtgtgtgt gttgtgtatg gactcactcc caggttcacc tggccacagg tgcacccttc     1140

ccacaccctt tacattcccc agagccaagg gagtttaagt ttgcagttac aggccagttc     1200

tccagctctc catcttagag agacaggtca ccttgcaggc ctgcttgcag gaaatgaatc     1260

cagcagccaa ctcgaatccc cctagggctc aggcactgag ggcctgggga cagtggagca     1320

tatgggtggg agacagatgg agggtaccct atttacaact gagtcagcca agccactgat     1380

gggaatatac agatttaggt gctaaaccat ttattttcca cggatgagtc acaatctgaa     1440

gaatcaaact tccatcctga aaatctatat gtttcaaaac cacttgccat cctgttagat     1500

tgccagttcc tgggaccagg cctcagactg tgaagtatat atcctccagc attcagtcca     1560

gggggagcca cggaaaccat gttcttgctt aagccattaa agtcagagat gaattctgga     1620

aaaaaaaaaa aaaaaaaaaa aa                                              1642


<210>  44
<211>  1283
<212>  DNA
<213>  Homo sapiens

<400>  44
gggggtgggg tccccggggc ggggcggggc gcgctgtgtc gcgggtcgga gctcggtcct       60

gctggaggcc acgggtgcca cacactcggt cccgacatga tggcgagcat gcgagtggtg      120

aaggagctgg aggatcttca gaagaagcct cccccatacc tgcggaacct gtccagcgat      180

gatgccaatg tcctggtgtg gcacgctctc ctcctacccg accaacctcc ctaccacctg      240

aaagccttca acctgcgcat cagcttcccg ccggagtatc cgttcaagcc tcccatgatc      300

aaattcacaa ccaagatcta ccaccccaac gtggacgaga acggacagat ttgcctgccc      360

atcatcagca gtgagaactg gaagccttgc accaagactt gccaagtcct ggaggccctc      420

aatgtgctgg tgaatagacc gaatatcagg gagcccctgc ggatggacct cgctgacctg      480

ctgacacaga atccggagct gttcagaaag aatgccgaag agttcaccct ccgattcgga      540

gtggaccggc cctcctaact catgttctga ccctctgtgc actggatcct cggcatagcg      600

gacggacaca cctcatggac tgaggccaga gccccctgtg gcccattccc cattcatttt      660

tcccttctta ggttgttagt cattagtttg tgtgtgtgtg tggtggaggg aagggagcta      720

tgagtgtgtg tgttgtgtat ggactcactc ccaggttcac ctggccacag gtgcaccctt      780

cccacaccct ttacattccc cagagccaag ggagtttaag tttgcagtta caggccagtt      840

ctccagctct ccatcttaga gagacaggtc accttgcagg cctgcttgca ggaaatgaat      900

ccagcagcca actcgaatcc ccctagggct caggcactga gggcctgggg acagtggagc      960

atatgggtgg gagacagatg gagggtaccc tatttacaac tgagtcagcc aagccactga     1020

tgggaatata cagatttagg tgctaaacca tttattttcc acggatgagt cacaatctga     1080

agaatcaaac ttccatcctg aaaatctata tgtttcaaaa ccacttgcca tcctgttaga     1140

ttgccagttc ctgggaccag gcctcagact gtgaagtata tatcctccag cattcagtcc     1200

agggggagcc acggaaacca tgttcttgct taagccatta aagtcagaga tgaattctgg     1260

aaaaaaaaaa aaaaaaaaaa aaa                                             1283


<210>  45
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ile Lys Phe Thr Thr Lys Ile Tyr His Pro Asn Val Asp Glu Asn 
1               5                   10                  15      


Gly Gln Ile Cys Leu Pro Ile Ile Ser Ser Glu Asn Trp Lys Pro Cys 
            20                  25                  30          


Thr Lys Thr Cys Gln Val Leu Glu Ala Leu Asn Val Leu Val Asn Arg 
        35                  40                  45              


Pro Asn Ile Arg Glu Pro Leu Arg Met Asp Leu Ala Asp Leu Leu Thr 
    50                  55                  60                  


Gln Asn Pro Glu Leu Phe Arg Lys Asn Ala Glu Glu Phe Thr Leu Arg 
65                  70                  75                  80  


Phe Gly Val Asp Arg Pro Ser 
                85          


<210>  46
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Met Ala Ser Met Arg Val Val Lys Glu Leu Glu Asp Leu Gln Lys 
1               5                   10                  15      


Lys Pro Pro Pro Tyr Leu Arg Asn Leu Ser Ser Asp Asp Ala Asn Val 
            20                  25                  30          


Leu Val Trp His Ala Leu Leu Leu Pro Asp Gln Pro Pro Tyr His Leu 
        35                  40                  45              


Lys Ala Phe Asn Leu Arg Ile Ser Phe Pro Pro Glu Tyr Pro Phe Lys 
    50                  55                  60                  


Pro Pro Met Ile Lys Phe Thr Thr Lys Ile Tyr His Pro Asn Val Asp 
65                  70                  75                  80  


Glu Asn Gly Gln Ile Cys Leu Pro Ile Ile Ser Ser Glu Asn Trp Lys 
                85                  90                  95      


Pro Cys Thr Lys Thr Cys Gln Val Leu Glu Ala Leu Asn Val Leu Val 
            100                 105                 110         


Asn Arg Pro Asn Ile Arg Glu Pro Leu Arg Met Asp Leu Ala Asp Leu 
        115                 120                 125             


Leu Thr Gln Asn Pro Glu Leu Phe Arg Lys Asn Ala Glu Glu Phe Thr 
    130                 135                 140                 


Leu Arg Phe Gly Val Asp Arg Pro Ser 
145                 150             


<210>  47
<211>  685
<212>  DNA
<213>  Homo sapiens

<400>  47
ataatagggc cggtgctgcc tgccgaagcc ggcggctgag aggcagcgaa ctcatctttg       60

ccagtacagg agcttgtgcc gtggcccaca gcccacagcc cacagccatg ggctgggacc      120

tgacggtgaa gatgctggcg ggcaacgaat tccaggtgtc cctgagcagc tccatgtcgg      180

tgtcagagct gaaggcgcag atcacccaga agatcggcgt gcacgccttc cagcagcgtc      240

tggctgtcca cccgagcggt gtggcgctgc aggacagggt cccccttgcc agccagggcc      300

tgggccccgg cagcacggtc ctgctggtgg tggacaaatg cgacgaacct ctgagcatcc      360

tggtgaggaa taacaagggc cgcagcagca cctacgaggt acggctgacg cagaccgtgg      420

cccacctgaa gcagcaagtg agcgggctgg agggtgtgca ggacgacctg ttctggctga      480

ccttcgaggg gaagcccctg gaggaccagc tcccgctggg ggagtacggc ctcaagcccc      540

tgagcaccgt gttcatgaat ctgcgcctgc ggggaggcgg cacagagcct ggcgggcgga      600

gctaagggcc tccaccagca tccgagcagg atcaagggcc ggaaataaag gctgttgtaa      660

agagaaaaaa aaaaaaaaaa aaaaa                                            685


<210>  48
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Gly Trp Asp Leu Thr Val Lys Met Leu Ala Gly Asn Glu Phe Gln 
1               5                   10                  15      


Val Ser Leu Ser Ser Ser Met Ser Val Ser Glu Leu Lys Ala Gln Ile 
            20                  25                  30          


Thr Gln Lys Ile Gly Val His Ala Phe Gln Gln Arg Leu Ala Val His 
        35                  40                  45              


Pro Ser Gly Val Ala Leu Gln Asp Arg Val Pro Leu Ala Ser Gln Gly 
    50                  55                  60                  


Leu Gly Pro Gly Ser Thr Val Leu Leu Val Val Asp Lys Cys Asp Glu 
65                  70                  75                  80  


Pro Leu Ser Ile Leu Val Arg Asn Asn Lys Gly Arg Ser Ser Thr Tyr 
                85                  90                  95      


Glu Val Arg Leu Thr Gln Thr Val Ala His Leu Lys Gln Gln Val Ser 
            100                 105                 110         


Gly Leu Glu Gly Val Gln Asp Asp Leu Phe Trp Leu Thr Phe Glu Gly 
        115                 120                 125             


Lys Pro Leu Glu Asp Gln Leu Pro Leu Gly Glu Tyr Gly Leu Lys Pro 
    130                 135                 140                 


Leu Ser Thr Val Phe Met Asn Leu Arg Leu Arg Gly Gly Gly Thr Glu 
145                 150                 155                 160 


Pro Gly Gly Arg Ser 
                165 


<210>  49
<211>  5889
<212>  DNA
<213>  Homo sapiens

<400>  49
gctgccagct gagttttttt gctgctttga gtctcagttt tctttctttc ctagagtctc       60

tgaagccaca gatctcttaa gaactttctg tctccaaacc gtggctgctc gataaatcag      120

acagaacagt taatcctcaa tttaagcctg atctaacccc tagaaacaga tatagaacaa      180

tggaagtgac aacaagattg acatggaatg atgaaaatca tctgcgcaag ctgcttggaa      240

atgtttcttt gagtcttctc tataagtcta gtgttcatgg aggtagcatt gaagatatgg      300

ttgaaagatg cagccgtcag ggatgtacta taacaatggc ttacattgat tacaatatga      360

ttgtagcctt tatgcttgga aattatatta atttacatga aagttctaca gagccaaatg      420

attccctatg gttttcactt caaaagaaaa atgacaccac tgaaatagaa actttactct      480

taaatacagc accaaaaatt attgatgagc aactggtgtg tcgtttatcg aaaacggata      540

ttttcattat atgtcgagat aataaaattt atctagataa aatgataaca agaaacttga      600

aactaaggtt ttatggccac cgtcagtatt tggaatgtga agtttttcga gttgaaggaa      660

ttaaggataa cctagacgac ataaagagga taattaaagc cagagagcac agaaataggc      720

ttctagcaga catcagagac tataggccct atgcagactt ggtttcagaa attcgtattc      780

ttttggtggg tccagttggg tctggaaagt ccagtttttt caattcagtc aagtctattt      840

ttcatggcca tgtgactggc caagccgtag tggggtctga tatcaccagc ataaccgagc      900

ggtataggat atattctgtt aaagatggaa aaaatggaaa atctctgcca tttatgttgt      960

gtgacactat ggggctagat ggggcagaag gagcaggact gtgcatggat gacattcccc     1020

acatcttaaa aggttgtatg ccagacagat atcagtttaa ttcccgtaaa ccaattacac     1080

ctgagcattc tacttttatc acctctccat ctctgaagga caggattcac tgtgtggctt     1140

atgtcttaga catcaactct attgacaatc tctactctaa aatgttggca aaagtgaagc     1200

aagttcacaa agaagtatta aactgtggta tagcatatgt ggccttgctt actaaagtgg     1260

atgattgcag tgaggttctt caagacaact ttttaaacat gagtagatct atgacttctc     1320

aaagccgggt catgaatgtc cataaaatgc taggcattcc tatttccaat attttgatgg     1380

ttggaaacta tgcttcagat ttggaactgg accccatgaa ggatattctc atcctctctg     1440

cactgaggca gatgctgcgg gctgcagatg attttttaga agatttgcct cttgaggaaa     1500

ctggtgcaat tgagagagcg ttacagccct gcatttgaga taagttgcct tgattctgac     1560

atttggccca gcctgtactg gtgtgccgca atgagagtca atctctattg acagcctgct     1620

tcagattttg cttttgttcg ttttgccttc tgtccttgga acagtcatat ctcaagttca     1680

aaggccaaaa cctgagaagc ggtgggctaa gataggtcct actgcaaacc acccctccat     1740

atttccgtac catttacaat tcagtttctg tgacatcttt ttaaaccact ggaggaaaaa     1800

tgagatattc tctaatttat tcttctataa cactctatat agagctatgt gagtactaat     1860

cacattgaat aatagttata aaattattgt atagacatct gcttcttaaa cagattgtga     1920

gttctttgag aaacagcgtg gattttactt atctgtgtat tcacagagct tagcacagtg     1980

cctggtaatg agcaagcata cttgccatta cttttccttc ccactctctc caacatcaca     2040

ttcactttaa atttttctgt atatagaaag gaaaactagc ctgggcaaca tgatgaaacc     2100

ccatctccac tgcaaaaaaa aaaaaaaaaa ataagaaaga acaaaacaaa ccccacaaaa     2160

attagctggg tatgatggca cgtgcctgta gtcccagtta ctcaggatga ttgattgagc     2220

cttggaggtg gaggctacag tgagctgaga ttgtgccact gtactctagc cagggagaaa     2280

gagtgagatc ctggctcaaa aaaaccaaat aaaacaaaac aaacaaacga aaaacagaaa     2340

ggaagactga aagagaatga aaagctgggg agaggaaata aaaataaaga aggaagagtg     2400

tttcatttat atctgaatga aaatatgaat gactctaagt aattgaatta attaaaatga     2460

gccaactttt ttttaacaat ttacatttta tttctatggg aaaaaataaa tattcctctt     2520

ctaacaaacc catgcttgat tttcattaat tgaattccaa atcatcctag ccatgtgtcc     2580

ttccatttag gttactgggg caaatcagta agaaagttct tatatttatg ctccaaataa     2640

ttctgaagtc ctcttactag ctgtgaaagc tagtactatt aagaaagaaa acaaaattcc     2700

caaaagatag ctttcacttt tttttttcct taaagacttc ctaattctct tctccaaatt     2760

cttagtcttc ttcaaaataa tatgctttgg ttcaatagtt atccacattc tgacagtcta     2820

atttagtttt aatcagaatt atactcatct tttgggtagt catagatatt aagaaagcaa     2880

gagtttctta tgtccagtta tggaatattt cctaaagcaa ggctgcaggt gaagttgtgc     2940

tcaagtgaat gttcaggaga cacaattcag tggaagaaat taagtcttta aaaaagacct     3000

aggaatagga gaaccatgga aattgaggag gtaggcctac aagtagatat tgggaacaaa     3060

attagagagg caaccagaaa aagttatttt aggctcacca gagttgttct tattgcacag     3120

taacacacca atataccaaa acagcaggta ttgcagtaga gaaagagttt aataattgaa     3180

tggcagaaaa atgaggaagg ttgaggaaac ctcaaatcta cctccctgct gagtctaagt     3240

ttaggatttt taagagaaag gcaggtaagg tgctgaaggt ctggagctgc tgatttgttg     3300

gggtataggg aatgaaatga aacatacaga gatgaaaact ggaagttttt ttttgtttgt     3360

tttgtttttt ttttgttgtt gttttttttt ttttttgttt ttttgctgag tcaattcctt     3420

ggagggggtc ttcagactga ctggtgtcag cagacccatg ggattccaag atctggaaaa     3480

ctttttagat agaaacttga tgtttcttaa cgttacatat attatcttat agaaataact     3540

aagggaagtt agtgccttgt gaccacatct atgtgacttt taggcagtaa gaaactataa     3600

ggaaaggagc taacagtcat gctgtaagta gctacaggga attggcttaa agggcaagtt     3660

ggttagtact tagctgtgtt tttattcaaa gtctacattt tatgtagtgg ttaatgtttg     3720

ctgttcatta ggatggtttc acagttacca tacaaatgta gaagcaacag gtccaaaaag     3780

tagggcatga ttttctccat gtaatccagg gagaaaacaa gccatgacca ttgttggttg     3840

ggagactgaa ggtgattgaa ggttcaccat catcctcacc aacttttggg ccataattca     3900

cccaaccctt tggtggagcc tgaaaaaaat ctgggcagaa tgtaggactt ctttattttg     3960

tttaaagggg taacacagag tgcccttatg aaggagttgg agatcctgca aggaagagaa     4020

ggagtgaagg agagatcaag agagagaaac aatgaggaac atttcatttg acccaacatc     4080

ctttaggagc ataaatgttg acactaagtt atcccttttg tgctaaaatg gacagtattg     4140

gcaaaatgat accacaactt cttattctct ggctctatat tgctttggaa acacttaaac     4200

atcaaatgga gttaaataca tatttgaaat ttaggttagg aaatattggt gaggaggcct     4260

caaaaagggg gaaacatctt ttgtctggga ggatattttc cattttgtgg atttccctga     4320

tctttttcta ccaccctgag gggtggtggg aattatcatt ttgctacatt ttagaggtca     4380

tccaggattt ttgaaacttt acattcttta cggttaagca agatgtacag ctcagtcaaa     4440

gacactaaat tcttcttaga aaaatagtgc taaggagtat agcagatgac ctatatgtgt     4500

gttggctggg agaatatcat cttaaagtga gagtgatgtt gtggagacag ttgaaatgtc     4560

aatgctagag cctctgtggt gtgaatgggc acgttaggtt gttgcattag aaagtgactg     4620

tttctgacag aaatttgtag ctttgtgcaa actcacccac catctacctc aataaaatat     4680

agagaaaaga aaaatagagc agtttgagtt ctatgaggta tgcaggccca gagagacata     4740

agtatgttcc tttagtcttg cttcctgtgt gccacactgc ccctccacaa ccatagctgg     4800

gggcaattgt ttaaagtcat tttgttcccg actagctgcc ttgcacatta tcttcatttt     4860

cctggaattt gatacagaga gcaatttata gccaattgat agcttatgct gtttcaatgt     4920

aaattcgtgg taaataactt aggaactgcc tcttcttttt ctttgaaaac ctacttataa     4980

ctgttgctaa taagaatgtg tattgttcag gacaacttgt ctccatacag ttgggttgta     5040

accctcatgc ttggcccaaa taaactctct acttatatca gtttttccta cacttcttcc     5100

ttttaggtca acaataccaa gaggggttac tgtgctgggt aatgtgtaaa cttgtgtctt     5160

gtttagaaag ataaatttaa agactatcac attgcttttt cataaaacaa gacaggtcta     5220

caattaattt attttgacgc aaattgatag gggggccaag taagccccat atgcttaatg     5280

atcagctgat gaataatcat ctcctagcaa cataactcaa tctaatgcta aggtacccac     5340

aagatggcaa ggctgatcaa agtcgtcatg gaatcctgca accaaaagcc atgggaattt     5400

ggaagccctc aaatcccatt cctaatctga tgagtctatg gaccaatttg tggaggacag     5460

tagattaaat agatctgatt tttgccatca atgtaaggag gataaaaact tgcataccaa     5520

ttgtacaccc ttgcaaaatc tttctctgat gttggagaaa atgggccagt gagatcatgg     5580

atatagaagt acagtcaatg ttcagctgta ccctcccaca atcccacttc cttcctcaac     5640

acaattcaaa caaatagact cagactgttt caggctccag gacaggaagt gcagtgtagg     5700

caaaattgca aaaattgagg gcacaggggt ggaggtgggg gggttgaata acaagctgtg     5760

ctaaataatt acgtgtaaat atattttttc atttttaaaa attgatttct tttgcacatt     5820

ccatgacaat atatgtcaca tttttaaaat aaatgcaaag aagcatacat ccaaaaaaaa     5880

aaaaaaaaa                                                             5889


<210>  50
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Glu Val Thr Thr Arg Leu Thr Trp Asn Asp Glu Asn His Leu Arg 
1               5                   10                  15      


Lys Leu Leu Gly Asn Val Ser Leu Ser Leu Leu Tyr Lys Ser Ser Val 
            20                  25                  30          


His Gly Gly Ser Ile Glu Asp Met Val Glu Arg Cys Ser Arg Gln Gly 
        35                  40                  45              


Cys Thr Ile Thr Met Ala Tyr Ile Asp Tyr Asn Met Ile Val Ala Phe 
    50                  55                  60                  


Met Leu Gly Asn Tyr Ile Asn Leu His Glu Ser Ser Thr Glu Pro Asn 
65                  70                  75                  80  


Asp Ser Leu Trp Phe Ser Leu Gln Lys Lys Asn Asp Thr Thr Glu Ile 
                85                  90                  95      


Glu Thr Leu Leu Leu Asn Thr Ala Pro Lys Ile Ile Asp Glu Gln Leu 
            100                 105                 110         


Val Cys Arg Leu Ser Lys Thr Asp Ile Phe Ile Ile Cys Arg Asp Asn 
        115                 120                 125             


Lys Ile Tyr Leu Asp Lys Met Ile Thr Arg Asn Leu Lys Leu Arg Phe 
    130                 135                 140                 


Tyr Gly His Arg Gln Tyr Leu Glu Cys Glu Val Phe Arg Val Glu Gly 
145                 150                 155                 160 


Ile Lys Asp Asn Leu Asp Asp Ile Lys Arg Ile Ile Lys Ala Arg Glu 
                165                 170                 175     


His Arg Asn Arg Leu Leu Ala Asp Ile Arg Asp Tyr Arg Pro Tyr Ala 
            180                 185                 190         


Asp Leu Val Ser Glu Ile Arg Ile Leu Leu Val Gly Pro Val Gly Ser 
        195                 200                 205             


Gly Lys Ser Ser Phe Phe Asn Ser Val Lys Ser Ile Phe His Gly His 
    210                 215                 220                 


Val Thr Gly Gln Ala Val Val Gly Ser Asp Ile Thr Ser Ile Thr Glu 
225                 230                 235                 240 


Arg Tyr Arg Ile Tyr Ser Val Lys Asp Gly Lys Asn Gly Lys Ser Leu 
                245                 250                 255     


Pro Phe Met Leu Cys Asp Thr Met Gly Leu Asp Gly Ala Glu Gly Ala 
            260                 265                 270         


Gly Leu Cys Met Asp Asp Ile Pro His Ile Leu Lys Gly Cys Met Pro 
        275                 280                 285             


Asp Arg Tyr Gln Phe Asn Ser Arg Lys Pro Ile Thr Pro Glu His Ser 
    290                 295                 300                 


Thr Phe Ile Thr Ser Pro Ser Leu Lys Asp Arg Ile His Cys Val Ala 
305                 310                 315                 320 


Tyr Val Leu Asp Ile Asn Ser Ile Asp Asn Leu Tyr Ser Lys Met Leu 
                325                 330                 335     


Ala Lys Val Lys Gln Val His Lys Glu Val Leu Asn Cys Gly Ile Ala 
            340                 345                 350         


Tyr Val Ala Leu Leu Thr Lys Val Asp Asp Cys Ser Glu Val Leu Gln 
        355                 360                 365             


Asp Asn Phe Leu Asn Met Ser Arg Ser Met Thr Ser Gln Ser Arg Val 
    370                 375                 380                 


Met Asn Val His Lys Met Leu Gly Ile Pro Ile Ser Asn Ile Leu Met 
385                 390                 395                 400 


Val Gly Asn Tyr Ala Ser Asp Leu Glu Leu Asp Pro Met Lys Asp Ile 
                405                 410                 415     


Leu Ile Leu Ser Ala Leu Arg Gln Met Leu Arg Ala Ala Asp Asp Phe 
            420                 425                 430         


Leu Glu Asp Leu Pro Leu Glu Glu Thr Gly Ala Ile Glu Arg Ala Leu 
        435                 440                 445             


Gln Pro Cys Ile 
    450         


<210>  51
<211>  3512
<212>  DNA
<213>  Homo sapiens

<400>  51
aactcagctg agtgttagtc aaagaaggtg tgtcctgctc cccaatgaca ggttgctcag       60

agactgctga tttccatccc tatataaaga gagtccctgg catacagaga ctgctctgct      120

ccaggcatct gccacaatgt gggtgcttac acctgctgct tttgctggga agctcttgag      180

tgtgttcagg caacctctga gctctctgtg gaggagcctg gtcccgctgt tctgctggct      240

gagggcaacc ttctggctgc tagctaccaa gaggagaaag cagcagctgg tcctgagagg      300

gccagatgag accaaagagg aggaagagga ccctcctctg cccaccaccc caaccagcgt      360

caactatcac ttcactcgcc agtgcaacta caaatgcggc ttctgtttcc acacagccaa      420

aacatccttt gtgctgcccc ttgaggaagc aaagagagga ttgcttttgc ttaaggaagc      480

tggtatggag aagatcaact tttcaggtgg agagccattt cttcaagacc ggggagaata      540

cctgggcaag ttggtgaggt tctgcaaagt agagttgcgg ctgcccagcg tgagcatcgt      600

gagcaatgga agcctgatcc gggagaggtg gttccagaat tatggtgagt atttggacat      660

tctcgctatc tcctgtgaca gctttgacga ggaagtcaat gtccttattg gccgtggcca      720

aggaaagaag aaccatgtgg aaaaccttca aaagctgagg aggtggtgta gggattatag      780

agtcgctttc aagataaatt ctgtcattaa tcgtttcaac gtggaagagg acatgacgga      840

acagatcaaa gcactaaacc ctgtccgctg gaaagtgttc cagtgcctct taattgaggg      900

tgagaattgt ggagaagatg ctctaagaga agcagaaaga tttgttattg gtgatgaaga      960

atttgaaaga ttcttggagc gccacaaaga agtgtcctgc ttggtgcctg aatctaacca     1020

gaagatgaaa gactcctacc ttattctgga tgaatatatg cgctttctga actgtagaaa     1080

gggacggaag gacccttcca agtccatcct ggatgttggt gtagaagaag ctataaaatt     1140

cagtggattt gatgaaaaga tgtttctgaa gcgaggagga aaatacatat ggagtaaggc     1200

tgatctgaag ctggattggt agagcggaaa gtggaacgag acttcaacac accagtggga     1260

aaactcctag agtaactgcc attgtctgca atactatccc gttggtattt cccagtggct     1320

gaaaacctga ttttctgctg cacgtggcat ctgattacct gtggtcactg aacacacgaa     1380

taacttggat agcaaatcct gagacaatgg aaaaccatta actttacttc attggcttat     1440

aaccttgttg ttattgaaac agcacttctg tttttgagtt tgttttagct aaaaagaagg     1500

aatacacaca ggaataatga ccccaaaaat gcttagataa ggcccctata cacaggacct     1560

gacatttagc tcaatgatgc gtttgtaaga aataagctct agtgatatct gtgggggcaa     1620

aatttaattt ggatttgatt ttttaaaaca atgtttactg cgatttctat atttccattt     1680

tgaaactatt tcttgttcca ggtttgttca tttgacagag tcagtatttt ttgccaaata     1740

tccagataac cagttttcac atctgagaca ttacaaagta tctgcctcaa ttatttctgc     1800

tggttataat gctttttttt ttttgccttt atgccattgc agtcttgtac tttttactgt     1860

gatgtacaga aatagtcaac agatgtttcc aagaacatat gatatgataa tcctaccaat     1920

tttcaagaag tctctagaaa gagataacac atggaaagac ggtgtggtgc agcccagccc     1980

acggtggctg ttccatgaat gctggctacc tatgtgtgtg gtacctgttg tgtccctttc     2040

tcttcaaaga tcctgagcaa aacaaagata cgctttccat ttgatgatgg agttgacatg     2100

gaggcagtgc ttgcattgct ttgttcgcct atcatctggc cacatgaggc tgtcaagcaa     2160

aagaatagga gtgtagttga gtagctggtt ggccctacat ctctgagaag tgacggcaca     2220

ctgggttggc ataagatatc ctaaaatcac gctggaacct tgggcaagga agaatgtgag     2280

caagagtaga gagagtgcct ggatttcatg tcagtgaagc caagtcacca tatcatattt     2340

ttgaatgaac tctgagtcag ttgaaatagg gtaccatcta ggtcagttta agaagagtca     2400

gctcagagaa agcaagcata agggaaaatg tcacgtaaac tagatcaggg aacaaaatcc     2460

tctccttgtg gaaatatccc atgcagtttg ttgatacaac ttagtatctt attgcctaaa     2520

aaaaaatttc ttatcattgt ttcaaaaaag caaaatcatg gaaaattttt gttgtccagg     2580

caaataaaag gtcattttaa tttagctgca atttcagtgt tcctcactag gtggcattta     2640

aatgtcgcct gatgtcatta agcaccatcc aaaaagtctg cttcataatc tattttcaag     2700

acttggtgat tctgaaagtt ttggtttttg tgactttgtt tctcaggaaa aaaaatattc     2760

ctacttaaat tttaagtcta taattcaatt taaatatgtg tgtgtctcat ccaggatagg     2820

ataggttgtc ttctattttc cattttacct atttactttt tttgtaagaa aagagaaaaa     2880

tgaattctaa agatgttccc catgggtttt gattgtgtct aagctatgat gaccttcata     2940

taatcagcat aaacataaaa caaatttttt acttaacatg agtgcacttt actaatcctc     3000

atggcacagt ggctcacgcc tgtaatccca gcacttggga ggacaatgtg ggtggatcac     3060

gaggtcagga gttcgagaac agcctggcca acatggtgaa accccgtctc cactaaaaat     3120

acaaaaatta gccaggcatg gtggcgtaca cttgtaattc cagctactca agaggctgag     3180

gcaggaggat tgcttgaacc ctgaaggcag aggttacaga gccaagatag cgccactgca     3240

ctccagcctg gatgacagag caagactccg tctcaaaaaa aaaaaaaaaa aaaagcaaga     3300

gagttcaact aagaaaggtc acatatgtga aagcccaagg acactgtttg atatacagca     3360

ggtattcaat cagtgttatt tgaaaccaaa tctgaatttg aagtttgaat cttctgagtt     3420

ggaatgaatt tttttctagc tgagggaaac tgtatttttc tttccccaaa gaggaatgta     3480

atgtaaagtg aaataaaact ataagctatg tt                                   3512


<210>  52
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
1               5                   10                  15      


Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
            20                  25                  30          


Cys Trp Leu Arg Ala Thr Phe Trp Leu Leu Ala Thr Lys Arg Arg Lys 
        35                  40                  45              


Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
    50                  55                  60                  


Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
65                  70                  75                  80  


Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                85                  90                  95      


Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
            100                 105                 110         


Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
        115                 120                 125             


Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
    130                 135                 140                 


Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
145                 150                 155                 160 


Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                165                 170                 175     


Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
            180                 185                 190         


Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
        195                 200                 205             


Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
    210                 215                 220                 


Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
225                 230                 235                 240 


Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                245                 250                 255     


Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
            260                 265                 270         


Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
        275                 280                 285             


Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
    290                 295                 300                 


Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
305                 310                 315                 320 


Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                325                 330                 335     


Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
            340                 345                 350         


Ser Lys Ala Asp Leu Lys Leu Asp Trp 
        355                 360     


<210>  53
<211>  665
<212>  DNA
<213>  Homo sapiens

<400>  53
gggaacacat ccaagcttaa gacggtgagg tcagcttcac attctcagga actctccttc       60

tttgggtctg gctgaagttg aggatctctt actctctagg ccacggaatt aacccgagca      120

ggcatggagg cctctgctct cacctcatca gcagtgacca gtgtggccaa agtggtcagg      180

gtggcctctg gctctgccgt agttttgccc ctggccagga ttgctacagt tgtgattgga      240

ggagttgtgg ccatggcggc tgtgcccatg gtgctcagtg ccatgggctt cactgcggcg      300

ggaatcgcct cgtcctccat agcagccaag atgatgtccg cggcggccat tgccaatggg      360

ggtggagttg cctcgggcag ccttgtggct actctgcagt cactgggagc aactggactc      420

tccggattga ccaagttcat cctgggctcc attgggtctg ccattgcggc tgtcattgcg      480

aggttctact agctccctgc ccctcgccct gcagagaaga gaaccatgcc aggggagaag      540

gcacccagcc atcctgaccc agcgaggagc caactatccc aaatatacct ggggtgaaat      600

ataccaaatt ctgcatctcc agaggaaaat aagaaataaa gatgaattgt tgcaactctt      660

caaaa                                                                  665


<210>  54
<211>  656
<212>  DNA
<213>  Homo sapiens

<400>  54
gggaacacat ccaagcttaa gacggtgagg tcagcttcac attctcagga actctccttc       60

tttgggtctg gctgaagttg aggatctctt actctctagg ccacggaatt aacccgagca      120

ggcatggagg cctctgctct cacctcatca gcagtgacca gtgtggccaa agtggtcagg      180

gtggcctctg gctctgccgt agttttgccc ctggccagga ttgctacagt tgtgattgga      240

ggagttgtgg ctgtgcccat ggtgctcagt gccatgggct tcactgcggc gggaatcgcc      300

tcgtcctcca tagcagccaa gatgatgtcc gcggcggcca ttgccaatgg gggtggagtt      360

gcctcgggca gccttgtggc tactctgcag tcactgggag caactggact ctccggattg      420

accaagttca tcctgggctc cattgggtct gccattgcgg ctgtcattgc gaggttctac      480

tagctccctg cccctcgccc tgcagagaag agaaccatgc caggggagaa ggcacccagc      540

catcctgacc cagcgaggag ccaactatcc caaatatacc tggggtgaaa tataccaaat      600

tctgcatctc cagaggaaaa taagaaataa agatgaattg ttgcaactct tcaaaa          656


<210>  55
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Glu Ala Ser Ala Leu Thr Ser Ser Ala Val Thr Ser Val Ala Lys 
1               5                   10                  15      


Val Val Arg Val Ala Ser Gly Ser Ala Val Val Leu Pro Leu Ala Arg 
            20                  25                  30          


Ile Ala Thr Val Val Ile Gly Gly Val Val Ala Met Ala Ala Val Pro 
        35                  40                  45              


Met Val Leu Ser Ala Met Gly Phe Thr Ala Ala Gly Ile Ala Ser Ser 
    50                  55                  60                  


Ser Ile Ala Ala Lys Met Met Ser Ala Ala Ala Ile Ala Asn Gly Gly 
65                  70                  75                  80  


Gly Val Ala Ser Gly Ser Leu Val Ala Thr Leu Gln Ser Leu Gly Ala 
                85                  90                  95      


Thr Gly Leu Ser Gly Leu Thr Lys Phe Ile Leu Gly Ser Ile Gly Ser 
            100                 105                 110         


Ala Ile Ala Ala Val Ile Ala Arg Phe Tyr 
        115                 120         


<210>  56
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Glu Ala Ser Ala Leu Thr Ser Ser Ala Val Thr Ser Val Ala Lys 
1               5                   10                  15      


Val Val Arg Val Ala Ser Gly Ser Ala Val Val Leu Pro Leu Ala Arg 
            20                  25                  30          


Ile Ala Thr Val Val Ile Gly Gly Val Val Ala Val Pro Met Val Leu 
        35                  40                  45              


Ser Ala Met Gly Phe Thr Ala Ala Gly Ile Ala Ser Ser Ser Ile Ala 
    50                  55                  60                  


Ala Lys Met Met Ser Ala Ala Ala Ile Ala Asn Gly Gly Gly Val Ala 
65                  70                  75                  80  


Ser Gly Ser Leu Val Ala Thr Leu Gln Ser Leu Gly Ala Thr Gly Leu 
                85                  90                  95      


Ser Gly Leu Thr Lys Phe Ile Leu Gly Ser Ile Gly Ser Ala Ile Ala 
            100                 105                 110         


Ala Val Ile Ala Arg Phe Tyr 
        115                 


<210>  57
<211>  4326
<212>  DNA
<213>  Homo sapiens

<400>  57
gctgagcgcg gagccgcccg gtgattggtg ggggcggaag ggggccgggc gccagcgctg       60

ccttttctcc tgccgggtag tttcgctttc ctgcgcagag tctgcggagg ggctcggctg      120

caccgggggg atcgcgcctg gcagacccca gaccgagcag aggcgaccca gcgcgctcgg      180

gagaggctgc accgccgcgc ccccgcctag cccttccgga tcctgcgcgc agaaaagttt      240

catttgctgt atgccatcct cgagagctgt ctaggttaac gttcgcactc tgtgtatata      300

acctcgacag tcttggcacc taacgtgctg tgcgtagctg ctcctttggt tgaatcccca      360

ggcccttgtt ggggcacaag gtggcaggat gtctcagtgg tacgaacttc agcagcttga      420

ctcaaaattc ctggagcagg ttcaccagct ttatgatgac agttttccca tggaaatcag      480

acagtacctg gcacagtggt tagaaaagca agactgggag cacgctgcca atgatgtttc      540

atttgccacc atccgttttc atgacctcct gtcacagctg gatgatcaat atagtcgctt      600

ttctttggag aataacttct tgctacagca taacataagg aaaagcaagc gtaatcttca      660

ggataatttt caggaagacc caatccagat gtctatgatc atttacagct gtctgaagga      720

agaaaggaaa attctggaaa acgcccagag atttaatcag gctcagtcgg ggaatattca      780

gagcacagtg atgttagaca aacagaaaga gcttgacagt aaagtcagaa atgtgaagga      840

caaggttatg tgtatagagc atgaaatcaa gagcctggaa gatttacaag atgaatatga      900

cttcaaatgc aaaaccttgc agaacagaga acacgagacc aatggtgtgg caaagagtga      960

tcagaaacaa gaacagctgt tactcaagaa gatgtattta atgcttgaca ataagagaaa     1020

ggaagtagtt cacaaaataa tagagttgct gaatgtcact gaacttaccc agaatgccct     1080

gattaatgat gaactagtgg agtggaagcg gagacagcag agcgcctgta ttggggggcc     1140

gcccaatgct tgcttggatc agctgcagaa ctggttcact atagttgcgg agagtctgca     1200

gcaagttcgg cagcagctta aaaagttgga ggaattggaa cagaaataca cctacgaaca     1260

tgaccctatc acaaaaaaca aacaagtgtt atgggaccgc accttcagtc ttttccagca     1320

gctcattcag agctcgtttg tggtggaaag acagccctgc atgccaacgc accctcagag     1380

gccgctggtc ttgaagacag gggtccagtt cactgtgaag ttgagactgt tggtgaaatt     1440

gcaagagctg aattataatt tgaaagtcaa agtcttattt gataaagatg tgaatgagag     1500

aaatacagta aaaggattta ggaagttcaa cattttgggc acgcacacaa aagtgatgaa     1560

catggaggag tccaccaatg gcagtctggc ggctgaattt cggcacctgc aattgaaaga     1620

acagaaaaat gctggcacca gaacgaatga gggtcctctc atcgttactg aagagcttca     1680

ctcccttagt tttgaaaccc aattgtgcca gcctggtttg gtaattgacc tcgagacgac     1740

ctctctgccc gttgtggtga tctccaacgt cagccagctc ccgagcggtt gggcctccat     1800

cctttggtac aacatgctgg tggcggaacc caggaatctg tccttcttcc tgactccacc     1860

atgtgcacga tgggctcagc tttcagaagt gctgagttgg cagttttctt ctgtcaccaa     1920

aagaggtctc aatgtggacc agctgaacat gttgggagag aagcttcttg gtcctaacgc     1980

cagccccgat ggtctcattc cgtggacgag gttttgtaag gaaaatataa atgataaaaa     2040

ttttcccttc tggctttgga ttgaaagcat cctagaactc attaaaaaac acctgctccc     2100

tctctggaat gatgggtgca tcatgggctt catcagcaag gagcgagagc gtgccctgtt     2160

gaaggaccag cagccgggga ccttcctgct gcggttcagt gagagctccc gggaaggggc     2220

catcacattc acatgggtgg agcggtccca gaacggaggc gaacctgact tccatgcggt     2280

tgaaccctac acgaagaaag aactttctgc tgttactttc cctgacatca ttcgcaatta     2340

caaagtcatg gctgctgaga atattcctga gaatcccctg aagtatctgt atccaaatat     2400

tgacaaagac catgcctttg gaaagtatta ctccaggcca aaggaagcac cagagccaat     2460

ggaacttgat ggccctaaag gaactggata tatcaagact gagttgattt ctgtgtctga     2520

agttcaccct tctagacttc agaccacaga caacctgctc cccatgtctc ctgaggagtt     2580

tgacgaggtg tctcggatag tgggctctgt agaattcgac agtatgatga acacagtata     2640

gagcatgaat ttttttcatc ttctctggcg acagttttcc ttctcatctg tgattccctc     2700

ctgctactct gttccttcac atcctgtgtt tctagggaaa tgaaagaaag gccagcaaat     2760

tcgctgcaac ctgttgatag caagtgaatt tttctctaac tcagaaacat cagttactct     2820

gaagggcatc atgcatctta ctgaaggtaa aattgaaagg cattctctga agagtgggtt     2880

tcacaagtga aaaacatcca gatacaccca aagtatcagg acgagaatga gggtcctttg     2940

ggaaaggaga agttaagcaa catctagcaa atgttatgca taaagtcagt gcccaactgt     3000

tataggttgt tggataaatc agtggttatt tagggaactg cttgacgtag gaacggtaaa     3060

tttctgtggg agaattctta catgttttct ttgctttaag tgtaactggc agttttccat     3120

tggtttacct gtgaaatagt tcaaagccaa gtttatatac aattatatca gtcctctttc     3180

aaaggtagcc atcatggatc tggtaggggg aaaatgtgta ttttattaca tctttcacat     3240

tggctattta aagacaaaga caaattctgt ttcttgagaa gagaatatta gctttactgt     3300

ttgttatggc ttaatgacac tagctaatat caatagaagg atgtacattt ccaaattcac     3360

aagttgtgtt tgatatccaa agctgaatac attctgcttt catcttggtc acatacaatt     3420

atttttacag ttctcccaag ggagttaggc tattcacaac cactcattca aaagttgaaa     3480

ttaaccatag atgtagataa actcagaaat ttaattcatg tttcttaaat gggctacttt     3540

gtcctttttg ttattagggt ggtatttagt ctattagcca caaaattggg aaaggagtag     3600

aaaaagcagt aactgacaac ttgaataata caccagagat aatatgagaa tcagatcatt     3660

tcaaaactca tttcctatgt aactgcattg agaactgcat atgtttcgct gatatatgtg     3720

tttttcacat ttgcgaatgg ttccattctc tctcctgtac tttttccaga cacttttttg     3780

agtggatgat gtttcgtgaa gtatactgta tttttacctt tttccttcct tatcactgac     3840

acaaaaagta gattaagaga tgggtttgac aaggttcttc ccttttacat actgctgtct     3900

atgtggctgt atcttgtttt tccactactg ctaccacaac tatattatca tgcaaatgct     3960

gtattcttct ttggtggaga taaagatttc ttgagttttg ttttaaaatt aaagctaaag     4020

tatctgtatt gcattaaata taatatgcac acagtgcttt ccgtggcact gcatacaatc     4080

tgaggcctcc tctctcagtt tttatataga tggcgagaac ctaagtttca gttgatttta     4140

caattgaaat gactaaaaaa caaagaagac aacattaaaa caatattgtt tctaattgct     4200

gaggtttagc tgtcagttct ttttgccctt tgggaattcg gcatggtttc attttactgc     4260

actagccaag agactttact tttaagaagt attaaaattc taaaattcaa aaaaaaaaaa     4320

aaaaaa                                                                4326


<210>  58
<211>  2798
<212>  DNA
<213>  Homo sapiens

<400>  58
gctgagcgcg gagccgcccg gtgattggtg ggggcggaag ggggccgggc gccagcgctg       60

ccttttctcc tgccgggtag tttcgctttc ctgcgcagag tctgcggagg ggctcggctg      120

caccgggggg atcgcgcctg gcagacccca gaccgagcag aggcgaccca gcgcgctcgg      180

gagaggctgc accgccgcgc ccccgcctag cccttccgga tcctgcgcgc agaaaagttt      240

catttgctgt atgccatcct cgagagctgt ctaggttaac gttcgcactc tgtgtatata      300

acctcgacag tcttggcacc taacgtgctg tgcgtagctg ctcctttggt tgaatcccca      360

ggcccttgtt ggggcacaag gtggcaggat gtctcagtgg tacgaacttc agcagcttga      420

ctcaaaattc ctggagcagg ttcaccagct ttatgatgac agttttccca tggaaatcag      480

acagtacctg gcacagtggt tagaaaagca agactgggag cacgctgcca atgatgtttc      540

atttgccacc atccgttttc atgacctcct gtcacagctg gatgatcaat atagtcgctt      600

ttctttggag aataacttct tgctacagca taacataagg aaaagcaagc gtaatcttca      660

ggataatttt caggaagacc caatccagat gtctatgatc atttacagct gtctgaagga      720

agaaaggaaa attctggaaa acgcccagag atttaatcag gctcagtcgg ggaatattca      780

gagcacagtg atgttagaca aacagaaaga gcttgacagt aaagtcagaa atgtgaagga      840

caaggttatg tgtatagagc atgaaatcaa gagcctggaa gatttacaag atgaatatga      900

cttcaaatgc aaaaccttgc agaacagaga acacgagacc aatggtgtgg caaagagtga      960

tcagaaacaa gaacagctgt tactcaagaa gatgtattta atgcttgaca ataagagaaa     1020

ggaagtagtt cacaaaataa tagagttgct gaatgtcact gaacttaccc agaatgccct     1080

gattaatgat gaactagtgg agtggaagcg gagacagcag agcgcctgta ttggggggcc     1140

gcccaatgct tgcttggatc agctgcagaa ctggttcact atagttgcgg agagtctgca     1200

gcaagttcgg cagcagctta aaaagttgga ggaattggaa cagaaataca cctacgaaca     1260

tgaccctatc acaaaaaaca aacaagtgtt atgggaccgc accttcagtc ttttccagca     1320

gctcattcag agctcgtttg tggtggaaag acagccctgc atgccaacgc accctcagag     1380

gccgctggtc ttgaagacag gggtccagtt cactgtgaag ttgagactgt tggtgaaatt     1440

gcaagagctg aattataatt tgaaagtcaa agtcttattt gataaagatg tgaatgagag     1500

aaatacagta aaaggattta ggaagttcaa cattttgggc acgcacacaa aagtgatgaa     1560

catggaggag tccaccaatg gcagtctggc ggctgaattt cggcacctgc aattgaaaga     1620

acagaaaaat gctggcacca gaacgaatga gggtcctctc atcgttactg aagagcttca     1680

ctcccttagt tttgaaaccc aattgtgcca gcctggtttg gtaattgacc tcgagacgac     1740

ctctctgccc gttgtggtga tctccaacgt cagccagctc ccgagcggtt gggcctccat     1800

cctttggtac aacatgctgg tggcggaacc caggaatctg tccttcttcc tgactccacc     1860

atgtgcacga tgggctcagc tttcagaagt gctgagttgg cagttttctt ctgtcaccaa     1920

aagaggtctc aatgtggacc agctgaacat gttgggagag aagcttcttg gtcctaacgc     1980

cagccccgat ggtctcattc cgtggacgag gttttgtaag gaaaatataa atgataaaaa     2040

ttttcccttc tggctttgga ttgaaagcat cctagaactc attaaaaaac acctgctccc     2100

tctctggaat gatgggtgca tcatgggctt catcagcaag gagcgagagc gtgccctgtt     2160

gaaggaccag cagccgggga ccttcctgct gcggttcagt gagagctccc gggaaggggc     2220

catcacattc acatgggtgg agcggtccca gaacggaggc gaacctgact tccatgcggt     2280

tgaaccctac acgaagaaag aactttctgc tgttactttc cctgacatca ttcgcaatta     2340

caaagtcatg gctgctgaga atattcctga gaatcccctg aagtatctgt atccaaatat     2400

tgacaaagac catgcctttg gaaagtatta ctccaggcca aaggaagcac cagagccaat     2460

ggaacttgat ggccctaaag gaactggata tatcaagact gagttgattt ctgtgtctga     2520

agtgtaagtg aacacagaag agtgacatgt ttacaaacct caagccagcc ttgctcctgg     2580

ctggggcctg ttgaagatgc ttgtatttta cttttccatt gtaattgcta tcgccatcac     2640

agctgaactt gttgagatcc ccgtgttact gcctatcagc attttactac tttaaaaaaa     2700

aaaaaaaagc caaaaaccaa atttgtattt aaggtatata aattttccca aaactgatac     2760

cctttgaaaa agtataaata aaatgagcaa aagttgat                             2798


<210>  59
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg 
                725                 730                 735     


Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val 
            740                 745                 750 


<210>  60
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val 
705                 710         


<210>  61
<211>  3330
<212>  DNA
<213>  Homo sapiens

<400>  61
cttttctttt ctccaggaag agagctgtga ccagcagcgt cccttattcg cttggccttg       60

gttcctgttt gcactggcta cagcagggca ctggccccta ctgtcaccgc cacctacaca      120

aagaccctat ctctgagcgc tgcagcctac tgttcagccc caggtttgag gatggatgcc      180

ctggacgctt cgaagctact ggatgaggag ctgtattcaa gacagctgta tgtgctgggc      240

tcacctgcca tgcagaggat tcagggagcc agggtcctgg tgtcaggcct gcagggcctg      300

ggggccgagg tggccaagaa cttggttctg atgggtgtgg gcagcctcac tctgcatgat      360

ccccacccca cctgctggtc cgacctggct gcccagtttc tcctctcaga gcaggacttg      420

gaaaggagca gagccgaggc ctctcaagag ctcttggctc agctcaacag agctgtccag      480

gtcgtcgtgc acacgggtga catcactgag gacctgctgt tggacttcca ggtggtggtg      540

ctgactgctg caaagctgga ggagcagctg aaggtgggca ccttgtgtca taagcatgga      600

gtttgctttc tggcggctga cacccggggc ctcgtggggc agttgttctg tgactttggt      660

gaggacttca ctgtgcagga ccccacagag gcagaacccc tgacagctgc catccagcac      720

atctcccagg gctcccctgg cattctcact ctgaggaaag gggccaatac ccactacttc      780

cgtgatggag acttggtgac tttctcggga attgagggaa tggttgagct caacgactgt      840

gatccccggt ctatccacgt gcgggaggat gggtccctgg agattggaga cacaacaact      900

ttctctcggt acttgcgtgg tggggctatc actgaagtca agagacccaa gactgtgaga      960

cataagtccc tggacacagc cctgctccag ccccatgtgg tggcccagag ctcccaggaa     1020

gttcaccatg cccactgcct gcatcaggcc ttctgtgcac tgcacaagtt ccagcacctc     1080

catggccggc caccccagcc ctgggatcct gttgatgcag agactgtggt gggcctggcc     1140

cgggacctgg aaccactgaa gcggacagag gaagagccac tggaagagcc actggatgag     1200

gccctagtgc ggacagtcgc cctaagcagt gcaggtgtct tgagccctat ggtggccatg     1260

ctgggtgcag tagctgccca ggaagtgctg aaggcaatct ccaggaagtt catgcctctg     1320

gaccagtggc tttactttga tgccctcgat tgtcttccgg aagatgggga gctccttccc     1380

agtcctgagg actgtgccct gagaggcagc cgctatgatg ggcaaattgc agtgtttggg     1440

gctggttttc aggagaaact gagacgccag cactacctcc tggtgggcgc tggtgccatt     1500

ggttgtgagc tgctcaaagt ctttgcccta gtgggactgg gggccgggaa cagcgggggc     1560

ttgactgttg ttgacatgga ccacatagag cgctccaatc tcagccgtca gttcctcttc     1620

aggtcccagg acgttggtag acccaaggca gaggtggctg cagcagctgc ccggggcctg     1680

aacccagact tacaggtgat cccgctcacc tacccactgg atcccaccac agagcacatc     1740

tatggggata actttttctc ccgtgtggat ggtgtggctg ctgccctgga cagtttccag     1800

gcccggcgct atgtggctgc tcgttgcacc cactatctga agccactgct ggaggcaggc     1860

acatcgggca cctggggcag tgctacagta ttcatgccac atgtgactga ggcctacaga     1920

gcccctgcct cagctgcagc ttctgaggat gccccctacc ctgtctgtac cgtgcggtac     1980

ttccctagca cagccgagca caccctgcag tgggcccggc atgagtttga agaactcttc     2040

cgactgtctg cagagaccat caaccaccac caacaggcac acacttccct ggcagacatg     2100

gatgagccac agacactcac cttactgaag ccagtgcttg gggtcctgag agtgcgtcca     2160

cagaactggc aagactgtgt ggcgtgggct cttggccact ggaaactctg ctttcattat     2220

ggcatcaaac agctgctgag gcacttccca cctaataaag tgcttgagga tggaactccc     2280

ttctggtcag gtcccaaaca gtgtccccag cccttggagt ttgacaccaa ccaagacaca     2340

cacctcctct acgtactggc agctgccaac ctgtatgccc agatgcatgg gctgcctggc     2400

tcacaggact ggactgcact cagggagctg ctgaagctgc tgccacagcc tgacccccaa     2460

cagatggccc ccatctttgc tagtaatcta gagctggctt cggcttctgc tgagtttggc     2520

cctgagcagc agaaggaact gaacaaagcc ctggaagtct ggagtgtggg ccctcccctg     2580

aagcctctga tgtttgagaa ggatgatgac agcaacttcc atgtggactt tgtggtagcg     2640

gcagctagcc tgagatgtca gaactacggg attccaccgg tcaaccgtgc ccagagcaag     2700

cgaattgtgg gccagattat cccagccatt gccaccacta cagcagctgt ggcaggcctg     2760

ttgggcctgg agctgtataa ggtggtgagt gggccacggc ctcgtagtgc ctttcgccac     2820

agctacctac atctggctga aaactacctc atccgctata tgccttttgc cccagccatc     2880

cagacgttcc atcacctgaa gtggacctct tgggaccgtc tgaaggtacc agctgggcag     2940

cctgagagga ccctggagtc gctgctggct catcttcagg agcagcacgg gttgagggtg     3000

aggatcctgc tgcacggctc agccctgctc tatgcggccg gatggtcacc tgaaaagcag     3060

gcccagcacc tgcccctcag ggtgacagaa ctggttcagc agctgacagg ccaggcacct     3120

gctcctgggc agcgggtgtt ggtgctagag ctgagctgtg agggtgacga cgaggacact     3180

gccttcccac ctctgcacta tgagctgtga caaggcagcc accctgtcac ctagctcaat     3240

ggagccccgg atcccaagcc ctgcattgta agcccacagt aggcactcaa taaatgcttg     3300

ttaaaggaag gcaaaaaaaa aaaaaaaaaa                                      3330


<210>  62
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Asp Ala Leu Asp Ala Ser Lys Leu Leu Asp Glu Glu Leu Tyr Ser 
1               5                   10                  15      


Arg Gln Leu Tyr Val Leu Gly Ser Pro Ala Met Gln Arg Ile Gln Gly 
            20                  25                  30          


Ala Arg Val Leu Val Ser Gly Leu Gln Gly Leu Gly Ala Glu Val Ala 
        35                  40                  45              


Lys Asn Leu Val Leu Met Gly Val Gly Ser Leu Thr Leu His Asp Pro 
    50                  55                  60                  


His Pro Thr Cys Trp Ser Asp Leu Ala Ala Gln Phe Leu Leu Ser Glu 
65                  70                  75                  80  


Gln Asp Leu Glu Arg Ser Arg Ala Glu Ala Ser Gln Glu Leu Leu Ala 
                85                  90                  95      


Gln Leu Asn Arg Ala Val Gln Val Val Val His Thr Gly Asp Ile Thr 
            100                 105                 110         


Glu Asp Leu Leu Leu Asp Phe Gln Val Val Val Leu Thr Ala Ala Lys 
        115                 120                 125             


Leu Glu Glu Gln Leu Lys Val Gly Thr Leu Cys His Lys His Gly Val 
    130                 135                 140                 


Cys Phe Leu Ala Ala Asp Thr Arg Gly Leu Val Gly Gln Leu Phe Cys 
145                 150                 155                 160 


Asp Phe Gly Glu Asp Phe Thr Val Gln Asp Pro Thr Glu Ala Glu Pro 
                165                 170                 175     


Leu Thr Ala Ala Ile Gln His Ile Ser Gln Gly Ser Pro Gly Ile Leu 
            180                 185                 190         


Thr Leu Arg Lys Gly Ala Asn Thr His Tyr Phe Arg Asp Gly Asp Leu 
        195                 200                 205             


Val Thr Phe Ser Gly Ile Glu Gly Met Val Glu Leu Asn Asp Cys Asp 
    210                 215                 220                 


Pro Arg Ser Ile His Val Arg Glu Asp Gly Ser Leu Glu Ile Gly Asp 
225                 230                 235                 240 


Thr Thr Thr Phe Ser Arg Tyr Leu Arg Gly Gly Ala Ile Thr Glu Val 
                245                 250                 255     


Lys Arg Pro Lys Thr Val Arg His Lys Ser Leu Asp Thr Ala Leu Leu 
            260                 265                 270         


Gln Pro His Val Val Ala Gln Ser Ser Gln Glu Val His His Ala His 
        275                 280                 285             


Cys Leu His Gln Ala Phe Cys Ala Leu His Lys Phe Gln His Leu His 
    290                 295                 300                 


Gly Arg Pro Pro Gln Pro Trp Asp Pro Val Asp Ala Glu Thr Val Val 
305                 310                 315                 320 


Gly Leu Ala Arg Asp Leu Glu Pro Leu Lys Arg Thr Glu Glu Glu Pro 
                325                 330                 335     


Leu Glu Glu Pro Leu Asp Glu Ala Leu Val Arg Thr Val Ala Leu Ser 
            340                 345                 350         


Ser Ala Gly Val Leu Ser Pro Met Val Ala Met Leu Gly Ala Val Ala 
        355                 360                 365             


Ala Gln Glu Val Leu Lys Ala Ile Ser Arg Lys Phe Met Pro Leu Asp 
    370                 375                 380                 


Gln Trp Leu Tyr Phe Asp Ala Leu Asp Cys Leu Pro Glu Asp Gly Glu 
385                 390                 395                 400 


Leu Leu Pro Ser Pro Glu Asp Cys Ala Leu Arg Gly Ser Arg Tyr Asp 
                405                 410                 415     


Gly Gln Ile Ala Val Phe Gly Ala Gly Phe Gln Glu Lys Leu Arg Arg 
            420                 425                 430         


Gln His Tyr Leu Leu Val Gly Ala Gly Ala Ile Gly Cys Glu Leu Leu 
        435                 440                 445             


Lys Val Phe Ala Leu Val Gly Leu Gly Ala Gly Asn Ser Gly Gly Leu 
    450                 455                 460                 


Thr Val Val Asp Met Asp His Ile Glu Arg Ser Asn Leu Ser Arg Gln 
465                 470                 475                 480 


Phe Leu Phe Arg Ser Gln Asp Val Gly Arg Pro Lys Ala Glu Val Ala 
                485                 490                 495     


Ala Ala Ala Ala Arg Gly Leu Asn Pro Asp Leu Gln Val Ile Pro Leu 
            500                 505                 510         


Thr Tyr Pro Leu Asp Pro Thr Thr Glu His Ile Tyr Gly Asp Asn Phe 
        515                 520                 525             


Phe Ser Arg Val Asp Gly Val Ala Ala Ala Leu Asp Ser Phe Gln Ala 
    530                 535                 540                 


Arg Arg Tyr Val Ala Ala Arg Cys Thr His Tyr Leu Lys Pro Leu Leu 
545                 550                 555                 560 


Glu Ala Gly Thr Ser Gly Thr Trp Gly Ser Ala Thr Val Phe Met Pro 
                565                 570                 575     


His Val Thr Glu Ala Tyr Arg Ala Pro Ala Ser Ala Ala Ala Ser Glu 
            580                 585                 590         


Asp Ala Pro Tyr Pro Val Cys Thr Val Arg Tyr Phe Pro Ser Thr Ala 
        595                 600                 605             


Glu His Thr Leu Gln Trp Ala Arg His Glu Phe Glu Glu Leu Phe Arg 
    610                 615                 620                 


Leu Ser Ala Glu Thr Ile Asn His His Gln Gln Ala His Thr Ser Leu 
625                 630                 635                 640 


Ala Asp Met Asp Glu Pro Gln Thr Leu Thr Leu Leu Lys Pro Val Leu 
                645                 650                 655     


Gly Val Leu Arg Val Arg Pro Gln Asn Trp Gln Asp Cys Val Ala Trp 
            660                 665                 670         


Ala Leu Gly His Trp Lys Leu Cys Phe His Tyr Gly Ile Lys Gln Leu 
        675                 680                 685             


Leu Arg His Phe Pro Pro Asn Lys Val Leu Glu Asp Gly Thr Pro Phe 
    690                 695                 700                 


Trp Ser Gly Pro Lys Gln Cys Pro Gln Pro Leu Glu Phe Asp Thr Asn 
705                 710                 715                 720 


Gln Asp Thr His Leu Leu Tyr Val Leu Ala Ala Ala Asn Leu Tyr Ala 
                725                 730                 735     


Gln Met His Gly Leu Pro Gly Ser Gln Asp Trp Thr Ala Leu Arg Glu 
            740                 745                 750         


Leu Leu Lys Leu Leu Pro Gln Pro Asp Pro Gln Gln Met Ala Pro Ile 
        755                 760                 765             


Phe Ala Ser Asn Leu Glu Leu Ala Ser Ala Ser Ala Glu Phe Gly Pro 
    770                 775                 780                 


Glu Gln Gln Lys Glu Leu Asn Lys Ala Leu Glu Val Trp Ser Val Gly 
785                 790                 795                 800 


Pro Pro Leu Lys Pro Leu Met Phe Glu Lys Asp Asp Asp Ser Asn Phe 
                805                 810                 815     


His Val Asp Phe Val Val Ala Ala Ala Ser Leu Arg Cys Gln Asn Tyr 
            820                 825                 830         


Gly Ile Pro Pro Val Asn Arg Ala Gln Ser Lys Arg Ile Val Gly Gln 
        835                 840                 845             


Ile Ile Pro Ala Ile Ala Thr Thr Thr Ala Ala Val Ala Gly Leu Leu 
    850                 855                 860                 


Gly Leu Glu Leu Tyr Lys Val Val Ser Gly Pro Arg Pro Arg Ser Ala 
865                 870                 875                 880 


Phe Arg His Ser Tyr Leu His Leu Ala Glu Asn Tyr Leu Ile Arg Tyr 
                885                 890                 895     


Met Pro Phe Ala Pro Ala Ile Gln Thr Phe His His Leu Lys Trp Thr 
            900                 905                 910         


Ser Trp Asp Arg Leu Lys Val Pro Ala Gly Gln Pro Glu Arg Thr Leu 
        915                 920                 925             


Glu Ser Leu Leu Ala His Leu Gln Glu Gln His Gly Leu Arg Val Arg 
    930                 935                 940                 


Ile Leu Leu His Gly Ser Ala Leu Leu Tyr Ala Ala Gly Trp Ser Pro 
945                 950                 955                 960 


Glu Lys Gln Ala Gln His Leu Pro Leu Arg Val Thr Glu Leu Val Gln 
                965                 970                 975     


Gln Leu Thr Gly Gln Ala Pro Ala Pro Gly Gln Arg Val Leu Val Leu 
            980                 985                 990         


Glu Leu Ser Cys Glu Gly Asp Asp  Glu Asp Thr Ala Phe  Pro Pro Leu 
        995                 1000                 1005             


His Tyr  Glu Leu 
    1010         


<210>  63
<211>  2808
<212>  DNA
<213>  Homo sapiens

<400>  63
gcggcggcgg cggcgcagtt tgctcatact ttgtgacttg cggtcacagt ggcattcagc       60

tccacacttg gtagaaccac aggcacgaca agcatagaaa catcctaaac aatcttcatc      120

gaggcatcga ggtccatccc aataaaaatc aggagaccct ggctatcata gaccttagtc      180

ttcgctggta tactcgctgt ctgtcaacca gcggttgact ttttttaagc cttctttttt      240

ctcttttacc agtttctgga gcaaattcag tttgccttcc tggatttgta aattgtaatg      300

acctcaaaac tttagcagtt cttccatctg actcaggttt gcttctctgg cggtcttcag      360

aatcaacatc cacacttccg tgattatctg cgtgcatttt ggacaaagct tccaaccagg      420

atacgggaag aagaaatggc tggtgatctt tcagcaggtt tcttcatgga ggaacttaat      480

acataccgtc agaagcaggg agtagtactt aaatatcaag aactgcctaa ttcaggacct      540

ccacatgata ggaggtttac atttcaagtt ataatagatg gaagagaatt tccagaaggt      600

gaaggtagat caaagaagga agcaaaaaat gccgcagcca aattagctgt tgagatactt      660

aataaggaaa agaaggcagt tagtccttta ttattgacaa caacgaattc ttcagaagga      720

ttatccatgg ggaattacat aggccttatc aatagaattg cccagaagaa aagactaact      780

gtaaattatg aacagtgtgc atcgggggtg catgggccag aaggatttca ttataaatgc      840

aaaatgggac agaaagaata tagtattggt acaggttcta ctaaacagga agcaaaacaa      900

ttggccgcta aacttgcata tcttcagata ttatcagaag aaacctcagt gaaatctgac      960

tacctgtcct ctggttcttt tgctactacg tgtgagtccc aaagcaactc tttagtgacc     1020

agcacactcg cttctgaatc atcatctgaa ggtgacttct cagcagatac atcagagata     1080

aattctaaca gtgacagttt aaacagttct tcgttgctta tgaatggtct cagaaataat     1140

caaaggaagg caaaaagatc tttggcaccc agatttgacc ttcctgacat gaaagaaaca     1200

aagtatactg tggacaagag gtttggcatg gattttaaag aaatagaatt aattggctca     1260

ggtggatttg gccaagtttt caaagcaaaa cacagaattg acggaaagac ttacgttatt     1320

aaacgtgtta aatataataa cgagaaggcg gagcgtgaag taaaagcatt ggcaaaactt     1380

gatcatgtaa atattgttca ctacaatggc tgttgggatg gatttgatta tgatcctgag     1440

accagtgatg attctcttga gagcagtgat tatgatcctg agaacagcaa aaatagttca     1500

aggtcaaaga ctaagtgcct tttcatccaa atggaattct gtgataaagg gaccttggaa     1560

caatggattg aaaaaagaag aggcgagaaa ctagacaaag ttttggcttt ggaactcttt     1620

gaacaaataa caaaaggggt ggattatata cattcaaaaa aattaattca tagagatctt     1680

aagccaagta atatattctt agtagataca aaacaagtaa agattggaga ctttggactt     1740

gtaacatctc tgaaaaatga tggaaagcga acaaggagta agggaacttt gcgatacatg     1800

agcccagaac agatttcttc gcaagactat ggaaaggaag tggacctcta cgctttgggg     1860

ctaattcttg ctgaacttct tcatgtatgt gacactgctt ttgaaacatc aaagtttttc     1920

acagacctac gggatggcat catctcagat atatttgata aaaaagaaaa aactcttcta     1980

cagaaattac tctcaaagaa acctgaggat cgacctaaca catctgaaat actaaggacc     2040

ttgactgtgt ggaagaaaag cccagagaaa aatgaacgac acacatgtta gagcccttct     2100

gaaaaagtat cctgcttctg atatgcagtt ttccttaaat tatctaaaat ctgctaggga     2160

atatcaatag atatttacct tttattttaa tgtttccttt aattttttac tatttttact     2220

aatctttctg cagaaacaga aaggttttct tctttttgct tcaaaaacat tcttacattt     2280

tactttttcc tggctcatct ctttattctt tttttttttt ttaaagacag agtctcgctc     2340

tgttgcccag gctggagtgc aatgacacag tcttggctca ctgcaacttc tgcctcttgg     2400

gttcaagtga ttctcctgcc tcagcctcct gagtagctgg attacaggca tgtgccaccc     2460

acccaactaa tttttgtgtt tttaataaag acagggtttc accatgttgg ccaggctggt     2520

ctcaaactcc tgacctcaag taatccacct gcctcggcct cccaaagtgc tgggattaca     2580

gggatgagcc accgcgccca gcctcatctc tttgttctaa agatggaaaa accaccccca     2640

aattttcttt ttatactatt aatgaatcaa tcaattcata tctatttatt aaatttctac     2700

cgcttttagg ccaaaaaaat gtaagatcgt tctctgcctc acatagctta caagccagct     2760

ggagaaatat ggtactcatt aaaaaaaaaa aaaaagtgat gtacaacc                  2808


<210>  64
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
1               5                   10                  15      


Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
            20                  25                  30          


Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
        35                  40                  45              


Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
    50                  55                  60                  


Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
65                  70                  75                  80  


Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                85                  90                  95      


Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
            100                 105                 110         


Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro 
        115                 120                 125             


Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile 
    130                 135                 140                 


Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
145                 150                 155                 160 


Ala Tyr Leu Gln Ile Leu Ser Glu Glu Thr Ser Val Lys Ser Asp Tyr 
                165                 170                 175     


Leu Ser Ser Gly Ser Phe Ala Thr Thr Cys Glu Ser Gln Ser Asn Ser 
            180                 185                 190         


Leu Val Thr Ser Thr Leu Ala Ser Glu Ser Ser Ser Glu Gly Asp Phe 
        195                 200                 205             


Ser Ala Asp Thr Ser Glu Ile Asn Ser Asn Ser Asp Ser Leu Asn Ser 
    210                 215                 220                 


Ser Ser Leu Leu Met Asn Gly Leu Arg Asn Asn Gln Arg Lys Ala Lys 
225                 230                 235                 240 


Arg Ser Leu Ala Pro Arg Phe Asp Leu Pro Asp Met Lys Glu Thr Lys 
                245                 250                 255     


Tyr Thr Val Asp Lys Arg Phe Gly Met Asp Phe Lys Glu Ile Glu Leu 
            260                 265                 270         


Ile Gly Ser Gly Gly Phe Gly Gln Val Phe Lys Ala Lys His Arg Ile 
        275                 280                 285             


Asp Gly Lys Thr Tyr Val Ile Lys Arg Val Lys Tyr Asn Asn Glu Lys 
    290                 295                 300                 


Ala Glu Arg Glu Val Lys Ala Leu Ala Lys Leu Asp His Val Asn Ile 
305                 310                 315                 320 


Val His Tyr Asn Gly Cys Trp Asp Gly Phe Asp Tyr Asp Pro Glu Thr 
                325                 330                 335     


Ser Asp Asp Ser Leu Glu Ser Ser Asp Tyr Asp Pro Glu Asn Ser Lys 
            340                 345                 350         


Asn Ser Ser Arg Ser Lys Thr Lys Cys Leu Phe Ile Gln Met Glu Phe 
        355                 360                 365             


Cys Asp Lys Gly Thr Leu Glu Gln Trp Ile Glu Lys Arg Arg Gly Glu 
    370                 375                 380                 


Lys Leu Asp Lys Val Leu Ala Leu Glu Leu Phe Glu Gln Ile Thr Lys 
385                 390                 395                 400 


Gly Val Asp Tyr Ile His Ser Lys Lys Leu Ile His Arg Asp Leu Lys 
                405                 410                 415     


Pro Ser Asn Ile Phe Leu Val Asp Thr Lys Gln Val Lys Ile Gly Asp 
            420                 425                 430         


Phe Gly Leu Val Thr Ser Leu Lys Asn Asp Gly Lys Arg Thr Arg Ser 
        435                 440                 445             


Lys Gly Thr Leu Arg Tyr Met Ser Pro Glu Gln Ile Ser Ser Gln Asp 
    450                 455                 460                 


Tyr Gly Lys Glu Val Asp Leu Tyr Ala Leu Gly Leu Ile Leu Ala Glu 
465                 470                 475                 480 


Leu Leu His Val Cys Asp Thr Ala Phe Glu Thr Ser Lys Phe Phe Thr 
                485                 490                 495     


Asp Leu Arg Asp Gly Ile Ile Ser Asp Ile Phe Asp Lys Lys Glu Lys 
            500                 505                 510         


Thr Leu Leu Gln Lys Leu Leu Ser Lys Lys Pro Glu Asp Arg Pro Asn 
        515                 520                 525             


Thr Ser Glu Ile Leu Arg Thr Leu Thr Val Trp Lys Lys Ser Pro Glu 
    530                 535                 540                 


Lys Asn Glu Arg His Thr Cys 
545                 550     


