                         SEQUENCE LISTING

<110>  The Johns Hopkins University
 
<120>  RIBOSOMAL PROTEIN S15 PHOSPHORYLATION MEDIATES LRRK2 
       NEURODEGENERATION IN PARKINSON'S DISEASE

<130>  P11516-04

<150>  61/977229
<151>  2014-04-09

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  158
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (46)..(46)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (54)..(54)
<223>  PHOSPHORYLATION

<400>  1

Met Ala Asp Ile Gln Thr Glu Arg Ala Tyr Gln Lys Gln Pro Thr Ile 
1               5                   10                  15      


Phe Gln Asn Lys Lys Arg Val Leu Leu Gly Glu Thr Gly Lys Glu Lys 
            20                  25                  30          


Leu Pro Arg Tyr Tyr Lys Asn Ile Gly Leu Gly Phe Lys Thr Pro Lys 
        35                  40                  45              


Glu Ala Ile Glu Gly Thr Tyr Ile Asp Lys Lys Cys Pro Phe Thr Gly 
    50                  55                  60                  


Asn Val Ser Ile Arg Gly Arg Ile Leu Ser Gly Val Val Thr Lys Met 
65                  70                  75                  80  


Lys Met Gln Arg Thr Ile Val Ile Arg Arg Asp Tyr Leu His Tyr Ile 
                85                  90                  95      


Arg Lys Tyr Asn Arg Phe Glu Lys Arg His Lys Asn Met Ser Val His 
            100                 105                 110         


Leu Ser Pro Cys Phe Arg Asp Val Gln Ile Gly Asp Ile Val Thr Val 
        115                 120                 125             


Gly Glu Cys Arg Pro Leu Ser Lys Thr Val Arg Phe Asn Val Leu Lys 
    130                 135                 140                 


Val Thr Lys Ala Ala Gly Thr Lys Lys Gln Phe Gln Lys Phe 
145                 150                 155             


<210>  2
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<400>  2

Glu Ala Ile Glu Gly Thr Tyr Ile Asp Lys Lys 
1               5                   10      


<210>  3
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<400>  3

Val Leu Leu Gly Glu Thr Gly Lys Glu Lys 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<400>  4

Asn Ile Gly Leu Gly Phe Lys Thr Pro Lys 
1               5                   10  


<210>  5
<211>  145
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (138)..(138)
<223>  PHOSPHORYLATION

<400>  5

Met Ala Glu Val Glu Gln Lys Lys Lys Arg Thr Phe Arg Lys Phe Thr 
1               5                   10                  15      


Tyr Arg Gly Val Asp Leu Asp Gln Leu Leu Asp Met Ser Tyr Glu Gln 
            20                  25                  30          


Leu Met Gln Leu Tyr Ser Ala Arg Gln Arg Arg Arg Leu Asn Arg Gly 
        35                  40                  45              


Leu Arg Arg Lys Gln His Ser Leu Leu Lys Arg Leu Arg Lys Ala Lys 
    50                  55                  60                  


Lys Glu Ala Pro Pro Met Glu Lys Pro Glu Val Val Lys Thr His Leu 
65                  70                  75                  80  


Arg Asp Met Ile Ile Leu Pro Glu Met Val Gly Ser Met Val Gly Val 
                85                  90                  95      


Tyr Asn Gly Lys Thr Phe Asn Gln Val Glu Ile Lys Pro Glu Met Ile 
            100                 105                 110         


Gly His Tyr Leu Gly Glu Phe Ser Ile Thr Tyr Lys Pro Val Lys His 
        115                 120                 125             


Gly Arg Pro Gly Ile Gly Ala Thr His Ser Ser Arg Phe Ile Pro Leu 
    130                 135                 140                 


Lys 
145 


<210>  6
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  PHOSPHORYLATION

<400>  6

His Gly Arg Pro Gly Ile Gly Ala Pro Thr His Ser Ser Arg 
1               5                   10                  


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  d.m. actin 5C forward primer

<400>  7
gtgaaatcgt ccgtgacatc                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  d.m. actin 5C reverse primer

<400>  8
ggcagctcgt aggacttctc                                                   20


<210>  9
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  d.m. alpha-tubulin forward primer

<400>  9
cacttccaat aaaaactcaa tatgcgtga                                         29


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  d.m. alpha-tubulin reverse primer

<400>  10
acagtgggtt ccagatccac                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  luciverase forward primer

<400>  11
tggagagcaa ctgcataagg                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  luciferase reverse primer

<400>  12
cgtttcatag cttctgccaa                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  eGFP forward primer

<400>  13
acgtaaacgg ccacaagttc                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  eGFP reverse primer

<400>  14
aagtcgtgct gcttcatgtg                                                   20


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h.s. GAPDH forward primer

<400>  15
aaacccatca ccatcttcca g                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h.s. GAPDH reverse primer

<400>  16
aggggccatc cacagtcttc t                                                 21


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h.s. alpha-tubulin forward primer

<400>  17
cgcccaacct acactaacct                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h.s. alpha-tubulin reverse primer

<400>  18
attcagggct ccatcaaatc                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h.s. beta-2-microglobulin forward primer

<400>  19
gactttgtca cagcccaaga                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h.s. beta-2-microglobulin reverse primer

<400>  20
caagcaagca gaatttggaa                                                   20


<210>  21
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h.s. beta-actin forward primer

<400>  21
agcctcgcct ttgccga                                                      17


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h.s. beta-actin reverse primer

<400>  22
gcgcggcgat atcatcatc                                                    19


<210>  23
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  PHOSPHORYLATION

<400>  23

Arg Pro Gly Ile Gly Ala Thr His Ser Ser Arg Phe Ile Pro Leu Lys 
1               5                   10                  15      


Cys 
    


