                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Reed, Elaine F
       Gritsch, Hans A
       Veale, Jeffrey L
 
<120>  PROTEIN BIOMARKERS FOR IMMUNE ASSESSMENT AND PREDICTION OF 
       TRANSPLANT REJECTION

<130>  UCLA215WOU1

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  1

Asn Val Asn Phe Gln Lys Ala Ile Asn Glu Lys Leu Gly Gln Tyr Ala 
1               5                   10                  15      


Ser Pro Thr Ala Lys Arg Cys Cys Gln Asp Gly Val Thr Arg Leu Pro 
            20                  25                  30          


Met Met Arg Ser Cys Glu Gln Arg Ala Ala Arg Val Gln Gln Pro Asp 
        35                  40                  45              


Cys Arg Glu Pro Phe Leu Ser Cys Cys Gln Phe Ala Glu Ser Leu Arg 
    50                  55                  60                  


Lys Lys Ser Arg Asp Lys Gly Gln Ala Gly Leu Gln Arg 
65                  70                  75          


<210>  2
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  2

Cys Cys Gln Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu 
1               5                   10                  15      


Gln Arg Ala Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu 
            20                  25                  30          


Ser Cys Cys Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser 
        35                  40                  45  


<210>  3
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Ala Lys Arg Cys Cys Gln Asp Gly Val Thr Arg Leu Pro Met Met 
1               5                   10                  15      


Arg Ser Cys Glu Gln Arg Ala Ala Arg Val Gln Gln Pro Asp Cys Arg 
            20                  25                  30          


Glu Pro Phe Leu Ser Cys Cys Gln Phe Ala Glu Ser Leu 
        35                  40                  45  


<210>  4
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  5
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu 
1               5                   10                  15      


Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His 
            20                  25                  30          


Val Asp Ala Leu 
        35      


<210>  6
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  7
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Arg Met Leu Pro Leu Leu Ala Leu Gly Leu Leu Ala Ala Gly 
1               5                   10                  15      


Phe Cys Pro Ala Val Leu Cys His Pro Asn Ser Pro Leu Asp Glu Glu 
            20                  25                  30          


Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly Thr His Val Asp Leu Gly 
        35                  40                  45              


Leu Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu 
    50                  55                  60                  


Val Leu Lys Ala Pro Asp Lys Asn Val Ile Phe Ser Pro Leu Ser Ile 
65                  70                  75                  80  


Ser Thr Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr Leu 
                85                  90                  95      


Thr Glu Ile Leu Lys Gly Leu Lys Phe Asn Leu Thr Glu Thr Ser Glu 
            100                 105                 110         


Ala Glu Ile His Gln Ser Phe Gln His Leu Leu Arg Thr Leu Asn Gln 
        115                 120                 125             


Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn Ala Met Phe Val Lys 
    130                 135                 140                 


Glu Gln Leu Ser Leu Leu Asp Arg Phe Thr Glu Asp Ala Lys Arg Leu 
145                 150                 155                 160 


Tyr Gly Ser Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser Ala Ala Ala 
                165                 170                 175     


Lys Lys Leu Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly Lys Ile 
            180                 185                 190         


Thr Asp Leu Ile Lys Asp Leu Asp Ser Gln Thr Met Met Val Leu Val 
        195                 200                 205             


Asn Tyr Ile Phe Phe Lys Ala Lys Trp Glu Met Pro Phe Asp Pro Gln 
    210                 215                 220                 


Asp Thr His Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys Trp Val Met 
225                 230                 235                 240 


Val Pro Met Met Ser Leu His His Leu Thr Ile Pro Tyr Phe Arg Asp 
                245                 250                 255     


Glu Glu Leu Ser Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn Ala 
            260                 265                 270         


Ser Ala Leu Phe Ile Leu Pro Asp Gln Asp Lys Met Glu Glu Val Glu 
        275                 280                 285             


Ala Met Leu Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp Ser Leu Glu 
    290                 295                 300                 


Phe Arg Glu Ile Gly Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser Arg 
305                 310                 315                 320 


Asp Tyr Asn Leu Asn Asp Ile Leu Leu Gln Leu Gly Ile Glu Glu Ala 
                325                 330                 335     


Phe Thr Ser Lys Ala Asp Leu Ser Gly Ile Thr Gly Ala Arg Asn Leu 
            340                 345                 350         


Ala Val Ser Gln Val Val His Lys Ala Val Leu Asp Val Phe Glu Glu 
        355                 360                 365             


Gly Thr Glu Ala Ser Ala Ala Thr Ala Val Lys Ile Thr Leu Leu Ser 
    370                 375                 380                 


Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe Leu 
385                 390                 395                 400 


Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser Lys 
                405                 410                 415     


Val Thr Asn Pro Lys Gln Ala 
            420             


<210>  8
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe Leu 
1               5                   10                  15      


Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser Lys 
            20                  25                  30          


Val Thr Asn Pro Lys Gln 
        35              


<210>  9
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Arg Met Leu Pro Leu Leu Ala Leu Gly Leu Leu Ala Ala Gly 
1               5                   10                  15      


Phe Cys Pro Ala Val Leu Cys His Pro Asn Ser Pro Leu Asp Glu Glu 
            20                  25                  30          


Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly Thr His Val Asp Leu Gly 
        35                  40                  45              


Leu Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu 
    50                  55                  60                  


Val Leu Lys Ala Leu Asp Lys Asn Val Ile Phe Ser Pro Leu Ser Ile 
65                  70                  75                  80  


Ser Thr Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr Leu 
                85                  90                  95      


Thr Glu Ile Leu Lys Ala Ser Ser Ser Pro His Gly Asp Leu Leu Arg 
            100                 105                 110         


Gln Lys Phe Thr Gln Ser Phe Gln His Leu Arg Ala Pro Ser Ile Ser 
        115                 120                 125             


Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn Ala Met Phe Val Lys 
    130                 135                 140                 


Glu Gln Leu Ser Leu Leu Asp Arg Phe Thr Glu Asp Ala Lys Arg Leu 
145                 150                 155                 160 


Tyr Gly Ser Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser Ala Ala Ala 
                165                 170                 175     


Lys Lys Leu Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly Lys Ile 
            180                 185                 190         


Thr Asp Leu Ile Lys Asp Pro Asp Ser Gln Thr Met Met Val Leu Val 
        195                 200                 205             


Asn Tyr Ile Phe Phe Lys Ala Lys Trp Glu Met Pro Phe Asp Pro Gln 
    210                 215                 220                 


Asp Thr His Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys Trp Val Met 
225                 230                 235                 240 


Val Pro Met Met Ser Leu His His Leu Thr Ile Pro Tyr Phe Arg Asp 
                245                 250                 255     


Glu Glu Leu Ser Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn Ala 
            260                 265                 270         


Ser Ala Leu Phe Ile Leu Pro Asp Gln Asp Lys Met Glu Glu Val Glu 
        275                 280                 285             


Ala Met Leu Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp Ser Leu Glu 
    290                 295                 300                 


Phe Arg Glu Ile Gly Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser Arg 
305                 310                 315                 320 


Asp Tyr Asn Leu Asn Asp Ile Leu Leu Gln Leu Gly Ile Glu Glu Ala 
                325                 330                 335     


Phe Thr Ser Lys Ala Asp Leu Ser Gly Ile Thr Gly Ala Arg Asn Leu 
            340                 345                 350         


Ala Val Ser Gln Val Val His Lys Val Val Ser Asp Val Phe Glu Glu 
        355                 360                 365             


Gly Thr Glu Ala Ser Ala Ala Thr Ala Val Lys Ile Thr Leu Leu Ser 
    370                 375                 380                 


Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe Leu 
385                 390                 395                 400 


Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser Lys 
                405                 410                 415     


Val Thr Asn Pro Ser Lys Pro Arg Ala Cys Ile Lys Gln Trp Gly Ser 
            420                 425                 430         


Gln 
    


<210>  10
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  11
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  11

Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val 
1               5                   10                  15      


Val Asn Pro Thr Gln Lys 
            20          


<210>  12
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


<210>  13
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
1               5                   10                  15      


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
            20                  25                  30          


Asp Pro Arg Ala 
        35      


<210>  14
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  14

Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val Gly Asp Met Gly 
1               5                   10                  15      


Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln Asn Ser Asn Arg 
            20                  25                  30          


Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln Arg Gly Pro Gly 
        35                  40                  45              


Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg Val Tyr Leu Gln 
    50                  55                  60                  


Gly Leu Ile Asp Cys Tyr Leu Phe Gly Asn Ser Ser Thr Val Leu Glu 
65                  70                  75                  80  


Asp Ser Lys Ser Asn Glu Lys Ala Glu Glu Trp Gly Arg Ser Gly Lys 
                85                  90                  95      


Asp Pro Asp Arg Phe Arg 
            100         


<210>  15
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  15

Val Phe Pro Lys Glu Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro 
1               5                   10                  15      


Leu Thr Lys Pro Leu Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr 
            20                  25                  30          


Glu Leu Ser Ser Thr Arg Gly Tyr Ser Ile Phe Ser Tyr Ala Thr Lys 
        35                  40                  45              


Arg Gln Asp Asn Glu Ile Leu Ile Phe Trp Ser Lys Asp Ile Gly Tyr 
    50                  55                  60                  


Ser Phe Thr Val Gly Gly Ser Glu Ile Leu Phe Glu Val Pro Glu Val 
65                  70                  75                  80  


Thr Val Ala Pro Val His Ile Cys Thr Ser Trp Glu Ser Ala Ser Gly 
                85                  90                  95      


Ile Val Glu Phe Trp Val Asp Gly Lys Pro Arg Val Arg Lys Ser Leu 
            100                 105                 110         


Lys Lys Gly Tyr Thr Val Gly Ala Glu Ala Ser Ile Ile Leu Gly Gln 
        115                 120                 125             


Glu Gln Asp Ser Phe Gly Gly Asn Phe Glu Gly Ser Gln Ser Leu Val 
    130                 135                 140                 


Gly Asp Ile Gly Asn Val Asn Met Trp Asp Phe Val Leu Ser Pro Asp 
145                 150                 155                 160 


Glu Ile Asn Thr Ile Tyr Leu Gly Gly Pro Phe Ser Pro Asn Val Leu 
                165                 170                 175     


<210>  16
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  16

Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu Arg Gln 
1               5                   10                  15      


Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu Gly Arg 
            20                  25                  30          


Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln Val Gln 
        35                  40                  45              


Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met 
    50                  55                  60                  


Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu 
65                  70                  75                  80  


Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu 
                85                  90                  95      


Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Cys 
            100                 105                 110         


Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln 
        115                 120                 125             


Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu 
    130                 135                 140                 


Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg Leu Ala 
145                 150                 155                 160 


Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu Ser Ala 
                165                 170                 175     


Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val Arg Ala 
            180                 185                 190         


Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg Ala Gln 
        195                 200                 205             


Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly Ser Arg 
    210                 215                 220                 


Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu Val Arg 
225                 230                 235                 240 


Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala Glu Ala 
                245                 250                 255     


Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu Asp Met 
            260                 265                 270         


Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala Val Gly 
        275                 280                 285             


Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
    290                 295                 


<210>  17
<211>  930
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Lys Pro Pro Arg Pro Val Arg Thr Cys Ser Lys Val Leu Val Leu 
1               5                   10                  15      


Leu Ser Leu Leu Ala Ile His Gln Thr Thr Thr Ala Glu Lys Asn Gly 
            20                  25                  30          


Ile Asp Ile Tyr Ser Leu Thr Val Asp Ser Arg Val Ser Ser Arg Phe 
        35                  40                  45              


Ala His Thr Val Val Thr Ser Arg Val Val Asn Arg Ala Asn Thr Val 
    50                  55                  60                  


Gln Glu Ala Thr Phe Gln Met Glu Leu Pro Lys Lys Ala Phe Ile Thr 
65                  70                  75                  80  


Asn Phe Ser Met Ile Ile Asp Gly Met Thr Tyr Pro Gly Ile Ile Lys 
                85                  90                  95      


Glu Lys Ala Glu Ala Gln Ala Gln Tyr Ser Ala Ala Val Ala Lys Gly 
            100                 105                 110         


Lys Ser Ala Gly Leu Val Lys Ala Thr Gly Arg Asn Met Glu Gln Phe 
        115                 120                 125             


Gln Val Ser Val Ser Val Ala Pro Asn Ala Lys Ile Thr Phe Glu Leu 
    130                 135                 140                 


Val Tyr Glu Glu Leu Leu Lys Arg Arg Leu Gly Val Tyr Glu Leu Leu 
145                 150                 155                 160 


Leu Lys Val Arg Pro Gln Gln Leu Val Lys His Leu Gln Met Asp Ile 
                165                 170                 175     


His Ile Phe Glu Pro Gln Gly Ile Ser Phe Leu Glu Thr Glu Ser Thr 
            180                 185                 190         


Phe Met Thr Asn Gln Leu Val Asp Ala Leu Thr Thr Trp Gln Asn Lys 
        195                 200                 205             


Thr Lys Ala His Ile Arg Phe Lys Pro Thr Leu Ser Gln Gln Gln Lys 
    210                 215                 220                 


Ser Pro Glu Gln Gln Glu Thr Val Leu Asp Gly Asn Leu Ile Ile Arg 
225                 230                 235                 240 


Tyr Asp Val Asp Arg Ala Ile Ser Gly Gly Ser Ile Gln Ile Glu Asn 
                245                 250                 255     


Gly Tyr Phe Val His Tyr Phe Ala Pro Glu Gly Leu Thr Thr Met Pro 
            260                 265                 270         


Lys Asn Val Val Phe Val Ile Asp Lys Ser Gly Ser Met Ser Gly Arg 
        275                 280                 285             


Lys Ile Gln Gln Thr Arg Glu Ala Leu Ile Lys Ile Leu Asp Asp Leu 
    290                 295                 300                 


Ser Pro Arg Asp Gln Phe Asn Leu Ile Val Phe Ser Thr Glu Ala Thr 
305                 310                 315                 320 


Gln Trp Arg Pro Ser Leu Val Pro Ala Ser Ala Glu Asn Val Asn Lys 
                325                 330                 335     


Ala Arg Ser Phe Ala Ala Gly Ile Gln Ala Leu Gly Gly Thr Asn Ile 
            340                 345                 350         


Asn Asp Ala Met Leu Met Ala Val Gln Leu Leu Asp Ser Ser Asn Gln 
        355                 360                 365             


Glu Glu Arg Leu Pro Glu Gly Ser Val Ser Leu Ile Ile Leu Leu Thr 
    370                 375                 380                 


Asp Gly Asp Pro Thr Val Gly Glu Thr Asn Pro Arg Ser Ile Gln Asn 
385                 390                 395                 400 


Asn Val Arg Glu Ala Val Ser Gly Arg Tyr Ser Leu Phe Cys Leu Gly 
                405                 410                 415     


Phe Gly Phe Asp Val Ser Tyr Ala Phe Leu Glu Lys Leu Ala Leu Asp 
            420                 425                 430         


Asn Gly Gly Leu Ala Arg Arg Ile His Glu Asp Ser Asp Ser Ala Leu 
        435                 440                 445             


Gln Leu Gln Asp Phe Tyr Gln Glu Val Ala Asn Pro Leu Leu Thr Ala 
    450                 455                 460                 


Val Thr Phe Glu Tyr Pro Ser Asn Ala Val Glu Glu Val Thr Gln Asn 
465                 470                 475                 480 


Asn Phe Arg Leu Leu Phe Lys Gly Ser Glu Met Val Val Ala Gly Lys 
                485                 490                 495     


Leu Gln Asp Arg Gly Pro Asp Val Leu Thr Ala Thr Val Ser Gly Lys 
            500                 505                 510         


Leu Pro Thr Gln Asn Ile Thr Phe Gln Thr Glu Ser Ser Val Ala Glu 
        515                 520                 525             


Gln Glu Ala Glu Phe Gln Ser Pro Lys Tyr Ile Phe His Asn Phe Met 
    530                 535                 540                 


Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Gln Leu Leu Glu Gln Thr 
545                 550                 555                 560 


Val Ser Ala Ser Asp Ala Asp Gln Gln Ala Leu Arg Asn Gln Ala Leu 
                565                 570                 575     


Asn Leu Ser Leu Ala Tyr Ser Phe Val Thr Pro Leu Thr Ser Met Val 
            580                 585                 590         


Val Thr Lys Pro Asp Asp Gln Glu Gln Ser Gln Val Ala Glu Lys Pro 
        595                 600                 605             


Met Glu Gly Glu Ser Arg Asn Arg Asn Val His Ser Gly Ser Thr Phe 
    610                 615                 620                 


Phe Lys Tyr Tyr Leu Gln Gly Ala Lys Ile Pro Lys Pro Glu Ala Ser 
625                 630                 635                 640 


Phe Ser Pro Arg Arg Gly Trp Asn Arg Gln Ala Gly Ala Ala Gly Ser 
                645                 650                 655     


Arg Met Asn Phe Arg Pro Gly Val Leu Ser Ser Arg Gln Leu Gly Leu 
            660                 665                 670         


Pro Gly Pro Pro Asp Val Pro Asp His Ala Ala Tyr His Pro Phe Arg 
        675                 680                 685             


Arg Leu Ala Ile Leu Pro Ala Ser Ala Pro Pro Ala Thr Ser Asn Pro 
    690                 695                 700                 


Asp Pro Ala Val Ser Arg Val Met Asn Met Lys Ile Glu Glu Thr Thr 
705                 710                 715                 720 


Met Thr Thr Gln Thr Pro Ala Pro Ile Gln Ala Pro Ser Ala Ile Leu 
                725                 730                 735     


Pro Leu Pro Gly Gln Ser Val Glu Arg Leu Cys Val Asp Pro Arg His 
            740                 745                 750         


Arg Gln Gly Pro Val Asn Leu Leu Ser Asp Pro Glu Gln Gly Val Glu 
        755                 760                 765             


Val Thr Gly Gln Tyr Glu Arg Glu Lys Ala Gly Phe Ser Trp Ile Glu 
    770                 775                 780                 


Val Thr Phe Lys Asn Pro Leu Val Trp Val His Ala Ser Pro Glu His 
785                 790                 795                 800 


Val Val Val Thr Arg Asn Arg Arg Ser Ser Ala Tyr Lys Trp Lys Glu 
                805                 810                 815     


Thr Leu Phe Ser Val Met Pro Gly Leu Lys Met Thr Met Asp Lys Thr 
            820                 825                 830         


Gly Leu Leu Leu Leu Ser Asp Pro Asp Lys Val Thr Ile Gly Leu Leu 
        835                 840                 845             


Phe Trp Asp Gly Arg Gly Glu Gly Leu Arg Leu Leu Leu Arg Asp Thr 
    850                 855                 860                 


Asp Arg Phe Ser Ser His Val Gly Gly Thr Leu Gly Gln Phe Tyr Gln 
865                 870                 875                 880 


Glu Val Leu Trp Gly Ser Pro Ala Ala Ser Asp Asp Gly Arg Arg Thr 
                885                 890                 895     


Leu Arg Val Gln Gly Asn Asp His Ser Ala Thr Arg Glu Arg Arg Leu 
            900                 905                 910         


Asp Tyr Gln Glu Gly Pro Pro Gly Val Glu Ile Ser Cys Trp Ser Val 
        915                 920                 925             


Glu Leu 
    930 


<210>  18
<211>  1474
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
            20                  25                  30          


Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys 
        35                  40                  45              


Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu 
    50                  55                  60                  


Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu 
65                  70                  75                  80  


Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                85                  90                  95      


Asn Glu Glu Val Met Phe Leu Thr Val Gln Val Lys Gly Pro Thr Gln 
            100                 105                 110         


Glu Phe Lys Lys Arg Thr Thr Val Met Val Lys Asn Glu Asp Ser Leu 
        115                 120                 125             


Val Phe Val Gln Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val 
    130                 135                 140                 


Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
145                 150                 155                 160 


Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala 
                165                 170                 175     


Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe Ser Phe 
            180                 185                 190         


Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys Val Val Val Gln 
        195                 200                 205             


Lys Lys Ser Gly Gly Arg Thr Glu His Pro Phe Thr Val Glu Glu Phe 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Gln Val Thr Val Pro Lys Ile Ile Thr 
225                 230                 235                 240 


Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Leu Tyr Thr Tyr 
                245                 250                 255     


Gly Lys Pro Val Pro Gly His Val Thr Val Ser Ile Cys Arg Lys Tyr 
            260                 265                 270         


Ser Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu 
        275                 280                 285             


Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val 
    290                 295                 300                 


Lys Thr Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met Lys Leu 
305                 310                 315                 320 


His Thr Glu Ala Gln Ile Gln Glu Glu Gly Thr Val Val Glu Leu Thr 
                325                 330                 335     


Gly Arg Gln Ser Ser Glu Ile Thr Arg Thr Ile Thr Lys Leu Ser Phe 
            340                 345                 350         


Val Lys Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe Phe Gly Gln 
        355                 360                 365             


Val Arg Leu Val Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile 
    370                 375                 380                 


Phe Ile Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp 
385                 390                 395                 400 


Glu His Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly 
                405                 410                 415     


Thr Ser Leu Thr Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys Tyr 
            420                 425                 430         


Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His His Thr Ala 
        435                 440                 445             


Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val His Leu Glu Pro Met 
    450                 455                 460                 


Ser His Glu Leu Pro Cys Gly His Thr Gln Thr Val Gln Ala His Tyr 
465                 470                 475                 480 


Ile Leu Asn Gly Gly Thr Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr 
                485                 490                 495     


Tyr Leu Ile Met Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly 
            500                 505                 510         


Leu Leu Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile 
        515                 520                 525             


Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala 
    530                 535                 540                 


Val Leu Pro Thr Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp Val 
545                 550                 555                 560 


Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ser Gln 
                565                 570                 575     


Ser Leu Pro Ala Ser His Ala His Leu Arg Val Thr Ala Ala Pro Gln 
            580                 585                 590         


Ser Val Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys 
        595                 600                 605             


Pro Asp Ala Glu Leu Ser Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu 
    610                 615                 620                 


Lys Asp Leu Thr Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asn Glu 
625                 630                 635                 640 


Asp Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Thr Tyr Thr 
                645                 650                 655     


Pro Val Ser Ser Thr Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp 
            660                 665                 670         


Met Gly Leu Lys Ala Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Met 
        675                 680                 685             


Cys Pro Gln Leu Gln Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg 
    690                 695                 700                 


Val Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His Ala Arg Leu 
705                 710                 715                 720 


Val His Val Glu Glu Pro His Thr Glu Thr Val Arg Lys Tyr Phe Pro 
                725                 730                 735     


Glu Thr Trp Ile Trp Asp Leu Val Val Val Asn Ser Ala Gly Val Ala 
            740                 745                 750         


Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly 
        755                 760                 765             


Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala 
    770                 775                 780                 


Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr 
785                 790                 795                 800 


Ser Val Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn 
                805                 810                 815     


Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln Leu Glu Ala Ser Pro 
            820                 825                 830         


Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys Ile 
        835                 840                 845             


Cys Ala Asn Gly Arg Gln Thr Val Ser Trp Ala Val Thr Pro Lys Ser 
    850                 855                 860                 


Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu Ser Gln 
865                 870                 875                 880 


Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg Lys 
                885                 890                 895     


Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys 
            900                 905                 910         


Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val Ser 
        915                 920                 925             


Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser Ala 
    930                 935                 940                 


Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln 
945                 950                 955                 960 


Asn Thr Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln Asn 
                965                 970                 975     


Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu 
            980                 985                 990         


Thr Gln Gln Leu Thr Pro Glu Ile  Lys Ser Lys Ala Ile  Gly Tyr Leu 
        995                 1000                 1005             


Asn Thr  Gly Tyr Gln Arg Gln  Leu Asn Tyr Lys His  Tyr Asp Gly 
    1010                 1015                 1020             


Ser Tyr  Ser Thr Phe Gly Glu  Arg Tyr Gly Arg Asn  Gln Gly Asn 
    1025                 1030                 1035             


Thr Trp  Leu Thr Ala Phe Val  Leu Lys Thr Phe Ala  Gln Ala Arg 
    1040                 1045                 1050             


Ala Tyr  Ile Phe Ile Asp Glu  Ala His Ile Thr Gln  Ala Leu Ile 
    1055                 1060                 1065             


Trp Leu  Ser Gln Arg Gln Lys  Asp Asn Gly Cys Phe  Arg Ser Ser 
    1070                 1075                 1080             


Gly Ser  Leu Leu Asn Asn Ala  Ile Lys Gly Gly Val  Glu Asp Glu 
    1085                 1090                 1095             


Val Thr  Leu Ser Ala Tyr Ile  Thr Ile Ala Leu Leu  Glu Ile Pro 
    1100                 1105                 1110             


Leu Thr  Val Thr His Pro Val  Val Arg Asn Ala Leu  Phe Cys Leu 
    1115                 1120                 1125             


Glu Ser  Ala Trp Lys Thr Ala  Gln Glu Gly Asp His  Gly Ser His 
    1130                 1135                 1140             


Val Tyr  Thr Lys Ala Leu Leu  Ala Tyr Ala Phe Ala  Leu Ala Gly 
    1145                 1150                 1155             


Asn Gln  Asp Lys Arg Lys Glu  Val Leu Lys Ser Leu  Asn Glu Glu 
    1160                 1165                 1170             


Ala Val  Lys Lys Asp Asn Ser  Val His Trp Glu Arg  Pro Gln Lys 
    1175                 1180                 1185             


Pro Lys  Ala Pro Val Gly His  Phe Tyr Glu Pro Gln  Ala Pro Ser 
    1190                 1195                 1200             


Ala Glu  Val Glu Met Thr Ser  Tyr Val Leu Leu Ala  Tyr Leu Thr 
    1205                 1210                 1215             


Ala Gln  Pro Ala Pro Thr Ser  Glu Asp Leu Thr Ser  Ala Thr Asn 
    1220                 1225                 1230             


Ile Val  Lys Trp Ile Thr Lys  Gln Gln Asn Ala Gln  Gly Gly Phe 
    1235                 1240                 1245             


Ser Ser  Thr Gln Asp Thr Val  Val Ala Leu His Ala  Leu Ser Lys 
    1250                 1255                 1260             


Tyr Gly  Ala Ala Thr Phe Thr  Arg Thr Gly Lys Ala  Ala Gln Val 
    1265                 1270                 1275             


Thr Ile  Gln Ser Ser Gly Thr  Phe Ser Ser Lys Phe  Gln Val Asp 
    1280                 1285                 1290             


Asn Asn  Asn Arg Leu Leu Leu  Gln Gln Val Ser Leu  Pro Glu Leu 
    1295                 1300                 1305             


Pro Gly  Glu Tyr Ser Met Lys  Val Thr Gly Glu Gly  Cys Val Tyr 
    1310                 1315                 1320             


Leu Gln  Thr Ser Leu Lys Tyr  Asn Ile Leu Pro Glu  Lys Glu Glu 
    1325                 1330                 1335             


Phe Pro  Phe Ala Leu Gly Val  Gln Thr Leu Pro Gln  Thr Cys Asp 
    1340                 1345                 1350             


Glu Pro  Lys Ala His Thr Ser  Phe Gln Ile Ser Leu  Ser Val Ser 
    1355                 1360                 1365             


Tyr Thr  Gly Ser Arg Ser Ala  Ser Asn Met Ala Ile  Val Asp Val 
    1370                 1375                 1380             


Lys Met  Val Ser Gly Phe Ile  Pro Leu Lys Pro Thr  Val Lys Met 
    1385                 1390                 1395             


Leu Glu  Arg Ser Asn His Val  Ser Arg Thr Glu Val  Ser Ser Asn 
    1400                 1405                 1410             


His Val  Leu Ile Tyr Leu Asp  Lys Val Ser Asn Gln  Thr Leu Ser 
    1415                 1420                 1425             


Leu Phe  Phe Thr Val Leu Gln  Asp Val Pro Val Arg  Asp Leu Lys 
    1430                 1435                 1440             


Pro Ala  Ile Val Lys Val Tyr  Asp Tyr Tyr Glu Thr  Asp Glu Phe 
    1445                 1450                 1455             


Ala Ile  Ala Glu Tyr Asn Ala  Pro Cys Ser Lys Asp  Leu Gly Asn 
    1460                 1465                 1470             


Ala 
    


