                         SEQUENCE LISTING

<110>  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       UNIVERSITE PAUL SABATIER TOULOUSE III
 
<120>  NOUVEAUX ANTICORPS UTILES POUR LE DIAGNOSTIC ET LE PRONOSTIC DU 
       CANCER

<130>  367600D32932

<150>  FR1453333
<151>  2014-04-14

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 1 utilis pour l'immunisation

<400>  1

Cys Lys His Ser Pro Asn Ile Val Gln Asp Leu Asn Lys Ser Arg Glu 
1               5                   10                  15      


His Thr Ser Ser 
            20  


<210>  2
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 2 utilis pour l'immunisation

<400>  2

Cys Ser Ile Phe Arg Ala Arg Lys Arg Ala Ser Leu Asp Ile Asn Lys 
1               5                   10                  15      


Glu Lys Pro Gly 
            20  


<210>  3
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 3 utilis pour l'immunisation

<400>  3

Cys Leu Gln Glu Asp Leu Ile Lys Lys Ser Asn Val Asn Glu Asn Gln 
1               5                   10                  15      


Asp Thr His 
            


<210>  4
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 4 utilis pour l'immunisation

<400>  4

His Asp Glu Thr Ser Ser Leu Leu Pro Arg Lys Glu Ser Asn Ile Val 
1               5                   10                  15      


Asp Asp Asn Gly Cys 
            20      


<210>  5
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 1B1 - CDR1H1

<400>  5

Gly Tyr Thr Phe Thr Asn Tyr Trp 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 1B1 - CDR1H2

<400>  6

Ile Asp Pro Ser Asp Arg Tyr Thr 
1               5               


<210>  7
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 1B1 - CDR1H3

<400>  7

Thr Met Tyr Ser Phe Ala Tyr 
1               5           


<210>  8
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 1B1 - CDR1L1

<400>  8

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  9
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 1B1 - CDR1L2

<400>  9

Leu Val Ser 
1           


<210>  10
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 1B1 - CDR1L3

<400>  10

Val Gln Gly Ala His Leu Pro Gln Thr 
1               5                   


<210>  11
<211>  114
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 1B1 - Domaine variable chaine lourde

<400>  11

Gln Val Gln Leu Gln Gln Pro Gly Ala Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gln Trp Ile Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Arg Tyr Thr Asn Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Met Tyr Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala 
        


<210>  12
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 1B1 - Domaine variable chaine lgre

<400>  12

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Ser Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Ala His Leu Pro Gln Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  13
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 18E1 - CDR2H1

<400>  13

Gly Asp Thr Phe Thr Asp Tyr Pro 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 18E1 - CDR2H2

<400>  14

Ile Asn Ala Glu Thr Ala Glu Pro 
1               5               


<210>  15
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 18E1 - CDR2H3

<400>  15

Ala Ser Ser Tyr Gly Tyr 
1               5       


<210>  16
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 18E1 - CDR2L1

<400>  16

Gln Ser Leu Leu Tyr Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  17
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 18E1 - CDR2L2

<400>  17

Leu Val Ser 
1           


<210>  18
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 18E1 - CDR2L3

<400>  18

Val Gln Gly Ser His Phe Pro His Thr 
1               5                   


<210>  19
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 18E1 - Domaine variable chaine lourde

<400>  19

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Asp Thr Phe Thr Asp Tyr 
            20                  25                  30          


Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Glu Thr Ala Glu Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Ser Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ser Ser Tyr Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ala 
    


<210>  20
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 18E1 - Domaine variable chaine lgre

<400>  20

Asp Ile Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Phe Gln Ser Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Ser His Phe Pro His Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
            100                 105                 110         


Arg 
    


<210>  21
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 10B2 - CDR3H1

<400>  21

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 10B2 - CDR3H2

<400>  22

Ile Asn Pro Asn Asn Gly Gly Ser 
1               5               


<210>  23
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 10B2 - CDR3H3

<400>  23

Ala Arg Gly Asp Tyr Ser Gly Thr Ser Phe Val Met Phe Ala His 
1               5                   10                  15  


<210>  24
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 10B2 - CDR3L1

<400>  24

Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  25
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 10B2 - CDR3L2

<400>  25

Tyr Met Ser 
1           


<210>  26
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 10B2 - CDR3L3

<400>  26

Met Gln Ser Leu Glu Tyr Pro Val Thr 
1               5                   


<210>  27
<211>  122
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 10B2 - Domaine variable chaine lourde

<400>  27

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Ser His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ile Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Ser Gly Thr Ser Phe Val Met Phe Ala His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  28
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 10B2 - Domaine variable chaine lgre

<400>  28

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Tyr Met Ser Asn Pro Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Gly Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Leu Glu Tyr Pro Val Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg 
    


<210>  29
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 15G9 - CDR4H1

<400>  29

Gly Tyr Thr Phe Thr Asp Tyr Ala 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 15G9 - CDR4H2

<400>  30

Ile Arg Thr Tyr Ser Gly Asp Ala 
1               5               


<210>  31
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 15G9 - CDR4H3

<400>  31

Ala Thr Gly Phe Asn Tyr 
1               5       


<210>  32
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 15G9 - CDR4L1

<400>  32

Gln Ser Leu Leu His Ser Asn Gly Lys Thr Tyr 
1               5                   10      


<210>  33
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 15G9 - CDR4L2

<400>  33

Leu Val Ser 
1           


<210>  34
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 15G9 - CDR4L3

<400>  34

Leu Gln Ala Thr His Phe Pro His Thr 
1               5                   


<210>  35
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 15G9 - Domaine variable chaine lourde

<400>  35

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Ala Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Phe Asn Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  36
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 15G9 - Domaine variable chaine lgre

<400>  36

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Leu Gln Ala 
                85                  90                  95      


Thr His Phe Pro His Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  37
<211>  446
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 10B2 - Chane lourde

<400>  37

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Ser His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ile Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Ser Gly Thr Ser Phe Val Met Phe Ala His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro 
        115                 120                 125             


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
            180                 185                 190         


Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
    210                 215                 220                 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
                245                 250                 255     


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Ile Asn Ser Thr Phe Arg Ser Val Ser Glu 
    290                 295                 300                 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
            340                 345                 350         


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
        355                 360                 365             


Thr Asn Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
    370                 375                 380                 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
385                 390                 395                 400 


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
                405                 410                 415     


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445     


<210>  38
<211>  219
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 10B2 - Chane lgre

<400>  38

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Tyr Met Ser Asn Pro Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Gly Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Leu Glu Tyr Pro Val Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  39
<211>  438
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 1B1 - Chane lourde

<400>  39

Gln Val Gln Leu Gln Gln Pro Gly Ala Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gln Trp Ile Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Arg Tyr Thr Asn Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Met Tyr Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly 
        115                 120                 125             


Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu 
145                 150                 155                 160 


Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr 
                165                 170                 175     


Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln 
            180                 185                 190         


Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
    210                 215                 220                 


Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
225                 230                 235                 240 


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
                245                 250                 255     


Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
            260                 265                 270         


Val Glu Val His Thr Ala Gln Thr Lys Pro Arg Glu Glu Gln Ile Asn 
        275                 280                 285             


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp 
    290                 295                 300                 


Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
305                 310                 315                 320 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
                325                 330                 335     


Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
            340                 345                 350         


Lys Val Ser Leu Thr Cys Met Ile Thr Asn Phe Phe Pro Glu Asp Ile 
        355                 360                 365             


Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
    370                 375                 380                 


Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
385                 390                 395                 400 


Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
                405                 410                 415     


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
            420                 425                 430         


Ser His Ser Pro Gly Lys 
        435             


<210>  40
<211>  219
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 1B1 - Chane lgre

<400>  40

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Ser Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Ala His Leu Pro Gln Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  41
<211>  443
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 18E1 - Chane lourde

<400>  41

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Asp Thr Phe Thr Asp Tyr 
            20                  25                  30          


Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Glu Thr Ala Glu Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Ser Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ser Ser Tyr Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ala Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys 
        115                 120                 125             


Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr 
                165                 170                 175     


Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser 
            180                 185                 190         


Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys 
        195                 200                 205             


Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys 
    210                 215                 220                 


Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
225                 230                 235                 240 


Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
            260                 265                 270         


Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
        275                 280                 285             


Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
    290                 295                 300                 


Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
305                 310                 315                 320 


Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
                325                 330                 335     


Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 
            340                 345                 350         


Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe 
        355                 360                 365             


Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu 
    370                 375                 380                 


Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr 
385                 390                 395                 400 


Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg 
                405                 410                 415     


Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His 
            420                 425                 430         


Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440             


<210>  42
<211>  219
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 18E1 - Chane lgre

<400>  42

Asp Ile Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Phe Gln Ser Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Ser His Phe Pro His Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  43
<211>  449
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 15G9 - Chane lourde

<400>  43

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Ala Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Phe Asn Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Cys 
        115                 120                 125             


Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly 
    130                 135                 140                 


Tyr Phe Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser 
145                 150                 155                 160 


Ser Ser Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly Leu Tyr Thr 
                165                 170                 175     


Met Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr 
            180                 185                 190         


Val Thr Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr Val Asp Lys 
        195                 200                 205             


Lys Leu Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro Pro 
    210                 215                 220                 


Cys Lys Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile Ser 
                245                 250                 255     


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp 
            260                 265                 270         


Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr 
        275                 280                 285             


Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg Val 
    290                 295                 300                 


Val Ser Thr Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr Ile 
            340                 345                 350         


Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp Thr 
    370                 375                 380                 


Ser Asn Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys Thr 
                405                 410                 415     


Ser Lys Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His Glu 
            420                 425                 430         


Gly Leu Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  44
<211>  219
<212>  PRT
<213>  artificial

<220>
<223>  Anticorps 15G9 - Chane lgre

<400>  44

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Leu Gln Ala 
                85                  90                  95      


Thr His Phe Pro His Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  45
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 1B1 - CDR1H1

<400>  45
ggctacacct tcaccaacta ctgg                                              24


<210>  46
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 1B1 - CDR1H2

<400>  46
attgatcctt ctgatagata tact                                              24


<210>  47
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 1B1 - CDR1H3

<400>  47
acaatgtatt cgtttgctta c                                                 21


<210>  48
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 1B1 - CDR1L1

<400>  48
cagagcctct tagatagtga tggaaaaacc tat                                    33


<210>  49
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 1B1 - CDR1L2

<400>  49
ctggtgtct                                                                9


<210>  50
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 1B1 - CDR1L3

<400>  50
gtgcaaggtg cacatctccc tcaaacg                                           27


<210>  51
<211>  342
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 1B1 - Domaine variable chaine lourde

<400>  51
caggtccaac tgcagcagcc tggggctgac cttgtgaagc ctggggcttc agtgaagctc       60

tcctgcaaga cctctggcta caccttcacc aactactgga tacagtggat aaaacagaag      120

cctggacagg gccttgagtg gatcggagag attgatcctt ctgatagata tactaattac      180

aatcaaagat tcaagggcaa ggccacattg actgtagaca catcctccag cacagcctac      240

atgcagctca acagcctaac atctgaggac tctgcggtct attactgtac aatgtattcg      300

tttgcttact ggggccaagg gactctggtc actgtctctg ca                         342


<210>  52
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 1B1 - Domaine variable chaine lgre

<400>  52
gatgttgtga tgacccagac tccactcact ttgtctgtta ccattggaca gccagcttcc       60

atttcttgca agtcaagtca gagcctctta gatagtgatg gaaaaaccta tttgaattgg      120

ttattacaga gtccaggcca gtctccaaag ctcttaatct atctggtgtc taagctggaa      180

tctggagtcc ctgacagatt cagtggcagt ggatcaggga cagattttac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattactgcg tgcaaggtgc acatctccct      300

caaacgttcg gatcggggac caaactggaa ataaaacgg                             339


<210>  53
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 18E1 - CDR1H1

<400>  53
ggtgacacct tcacagacta tcca                                              24


<210>  54
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 18E1 - CDR1H2

<400>  54
ataaacgctg agactgctga gcca                                              24


<210>  55
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 18E1 - CDR1H3

<400>  55
gctagttcct atggttac                                                     18


<210>  56
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 18E1 - CDR1L1

<400>  56
cagagcctct tatatagtga tggaaaaacc tat                                    33


<210>  57
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 18E1 - CDR1L2

<400>  57
ctggtgtct                                                                9


<210>  58
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 18E1 - CDR1L3

<400>  58
gtgcaaggtt cacatttccc tcatacg                                           27


<210>  59
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 18E1 - Domaine variable chaine lourde

<400>  59
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctggtga caccttcaca gactatccaa tgcactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacgctg agactgctga gccaacatat      180

gtagacgact tcaagggacg gtttgccttc tctttggaat cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc tagttcctat      300

ggttactggg gccaagggac tctggtcact gtctctgca                             339


<210>  60
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 18E1 - Domaine variable chaine lgre

<400>  60
gatattgtga tgacccagac tccactcact ttgtctgtta ccattggaca gccagcttcc       60

atttcttgca agtcaagtca gagcctctta tatagtgatg gaaaaaccta tttgaattgg      120

ttattccaga gtccaggcca gtctccaaag ctcttaatct atctggtgtc taaactggaa      180

tctggagtcc ctgacagatt cagtggcagt ggatcaggga cagattttac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattactgcg tgcaaggttc acatttccct      300

catacgttcg gatcggggac caagctggaa ataaaccgg                             339


<210>  61
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 15G9 - CDR1H1

<400>  61
ggctacacat tcactgatta tgct                                              24


<210>  62
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 15G9 - CDR1H2

<400>  62
attcgtactt actctggtga tgct                                              24


<210>  63
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 15G9 - CDR1H3

<400>  63
gcaaccgggt ttaactac                                                     18


<210>  64
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 15G9 - CDR1L1

<400>  64
cagagcctct tacatagtaa tggaaagaca tat                                    33


<210>  65
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 15G9 - CDR1L2

<400>  65
ctggtgtct                                                                9


<210>  66
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 15G9 - CDR1L3

<400>  66
ttgcaagcta cacattttcc tcatacg                                           27


<210>  67
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 15G9 - Domaine variable chaine lourde

<400>  67
caggtccagc tgcagcagtc tggggctgag ctggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttctggcta cacattcact gattatgcta tgcactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attcgtactt actctggtga tgctacctac      180

aaccagaagt tcaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagactgac atctgaggat tctgccatct attactgtgc aaccgggttt      300

aactactggg gccaaggcac cactctcaca gtctcctca                             339


<210>  68
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 15G9 - Domaine variable chaine lgre

<400>  68
gatgttgtga tgactcagac cccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca aatcaagtca gagcctctta catagtaatg gaaagacata tttgaattgg      120

ttattacaga ggccaggcca gtctccaaag ctcttaatct atctggtgtc taaactggaa      180

tctggagtcc ctgacaggtt cagtggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggactt tattactgct tgcaagctac acattttcct      300

catacgttcg gatcggggac caagctggaa ataaaacgg                             339


<210>  69
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 10B2 - CDR1H1

<400>  69
ggatacacgt tcactgatta ctac                                              24


<210>  70
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 10B2 - CDR1H2

<400>  70
attaatccta ataatggtgg tagt                                              24


<210>  71
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 10B2 - CDR1H3

<400>  71
gcaagaggcg attactccgg tactagtttc gttatgtttg ctcac                       45


<210>  72
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 10B2 - CDR1L1

<400>  72
aagagtcttc tgcacagtaa tggcaacact tac                                    33


<210>  73
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 10B2 - CDR1L2

<400>  73
tatatgtcc                                                                9


<210>  74
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 10B2 - CDR1L3

<400>  74
atgcaaagtc tagaatatcc tgtcacg                                           27


<210>  75
<211>  366
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 10B2 - Domaine variable chaine lourde

<400>  75
gaggtccagc tgcaacaatc tggacctgag ctggtgaagc ctggggcctc agttaagatt       60

tcctgtaagg cttctggata cacgttcact gattactaca tgaactgggt gaagcagagc      120

catggaaaga cccttgagtg gattggagat attaatccta ataatggtgg tagtcactac      180

aaccagaagt tcaggggcaa ggccacattg actatagaca agtcctccag tacagcctac      240

atggacctcc gcagcctgac atctgaagac tctgcagtct attactgtgc aagaggcgat      300

tactccggta ctagtttcgt tatgtttgct cactggggcc aagggactct ggtcactgtc      360

tctgca                                                                 366


<210>  76
<211>  339
<212>  DNA
<213>  artificial

<220>
<223>  Anticorps 10B2 - Domaine variable chaine lgre

<400>  76
gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc       60

atctcctgca ggtctactaa gagtcttctg cacagtaatg gcaacactta cttgtattgg      120

ttcctgcaga ggccaggcca gtctcctcaa ctcctgatat attatatgtc caaccctgcc      180

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgatttcac actgaggatc      240

agtcgagtgg gggctgagga tgtaggtatt tattactgta tgcaaagtct agaatatcct      300

gtcacgttcg gtgcggggac caagctggag ctgaaacgg                             339


