                         SEQUENCE LISTING

<110>  Boehringer Ingelheim et al.
 
<120>  RECOMBINANT HOST CELL  FOR EXPRESSING PROTEINS OF INTEREST

<130>  BOE14959PCT

<150>  EP14165188
<151>  2014-04-17

<160>  163   

<170>  PatentIn version 3.5

<210>  1
<211>  95
<212>  PRT
<213>  Pichia pastoris

<400>  1

Met Leu Asn Lys Leu Phe Ile Ala Ile Leu Ile Val Ile Thr Ala Val 
1               5                   10                  15      


Ile Gly Glu Thr Thr Thr Ser Ser Thr Thr Ala Ser Leu Ser Glu Ser 
            20                  25                  30          


Pro Thr Leu Val Trp Val Thr Gly Thr Asp Ala Ser Gly Arg Leu Ala 
        35                  40                  45              


Thr Thr Gln Ser Ala Tyr Thr Gln Gln Phe Ser Gln Leu Tyr Ser Ser 
    50                  55                  60                  


Ile Ala Ser Pro Ser Ser Gly Ser Ile Gly Leu Gly Thr Ile Gln Gly 
65                  70                  75                  80  


Thr Val Gly Ile Val Arg Thr Tyr Glu Thr Ile Thr Leu Ala Ser 
                85                  90                  95  


<210>  2
<211>  86
<212>  PRT
<213>  Pichia pastoris

<400>  2

Met Ser Thr Ala Ile Pro Gly Gly Gln Arg Thr Leu Ala Lys Arg Arg 
1               5                   10                  15      


Ala Ala Asn Leu Asp Lys Lys Gln Asp Glu Pro Thr Ser Ala Arg Ser 
            20                  25                  30          


Ala Gly Ala Gly Gly Ser Ser Ser Thr Met Leu Lys Leu Tyr Thr Asp 
        35                  40                  45              


Glu Ala Gln Gly Leu Lys Val Asp Pro Leu Ile Val Leu Val Leu Ala 
    50                  55                  60                  


Val Gly Phe Ile Phe Ser Val Ile Gly Leu His Val Val Ala Lys Leu 
65                  70                  75                  80  


Thr Gly Lys Leu Ile Asn 
                85      


<210>  3
<211>  361
<212>  PRT
<213>  Pichia pastoris

<400>  3

Met Thr Pro Arg Ser His Ile Phe Phe Asp Ile Ser Ile Asn Asn Gln 
1               5                   10                  15      


Pro Ala Gly Arg Ile Ile Phe Glu Leu Phe Asn Asp Ile Val Pro Lys 
            20                  25                  30          


Thr Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Ile Gly 
        35                  40                  45              


Lys Ser Gly Lys Pro Leu His Tyr Lys Gly Ser Thr Phe His Arg Ile 
    50                  55                  60                  


Ile Lys Asp Phe Met Val Gln Gly Gly Asp Phe Thr Asn Gly Asn Gly 
65                  70                  75                  80  


Thr Gly Gly Glu Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe 
                85                  90                  95      


Gln Leu Thr His Asp Lys Pro Phe Leu Leu Ser Met Ala Asn Ala Gly 
            100                 105                 110         


Pro Gly Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Val Pro Thr Pro 
        115                 120                 125             


His Leu Asp Asn Lys His Val Val Phe Gly Lys Val Ile Ala Gly Lys 
    130                 135                 140                 


Ala Thr Val Arg Lys Ile Glu Arg Asn Ser Glu Gly Glu Ala Pro Ile 
145                 150                 155                 160 


Glu Pro Val Val Ile Glu Asp Cys Gly Glu Leu Pro Glu Asp Ala Asp 
                165                 170                 175     


Leu Thr Ile Ser Asp Glu Thr Gly Asp Lys Tyr Glu Glu Val Leu Lys 
            180                 185                 190         


Asp Asn Glu Asn Ile Asp Ile Asp Asp Phe Glu Gln Val Tyr Gln Ala 
        195                 200                 205             


Ile Thr Glu Ile Lys Glu Leu Gly Thr Lys Tyr Phe Lys Asn Gly Asp 
    210                 215                 220                 


Thr Lys Ile Ala Phe Glu Lys Tyr Gln Lys Ala Ala Asn Tyr Leu Leu 
225                 230                 235                 240 


Glu Tyr Ile Pro Ser Asp Leu Ser Glu Glu Gln Ser Ser Lys Leu Glu 
                245                 250                 255     


Leu Leu Lys Thr Ser Val Phe Ser Asn Val Ala Leu Ala Gly Leu Lys 
            260                 265                 270         


Val Ser Lys Phe Lys Asp Thr Ile Lys Tyr Ala Thr Leu Val Ile Glu 
        275                 280                 285             


Asp Glu Ser Ala Asp Ala Lys Ala Lys Ser Lys Gly Tyr Tyr Arg Arg 
    290                 295                 300                 


Gly Ser Ala Tyr Ser Ser Leu Lys Asp Glu Asp Ser Ala Ile Ser Asp 
305                 310                 315                 320 


Phe Gln Lys Ala Leu Glu Leu Ser Pro Gly Asp Pro Ala Ile Ser Gln 
                325                 330                 335     


Ser Leu Gln Arg Thr Thr Lys Ala Arg Lys Asp Arg Leu Ala Lys Glu 
            340                 345                 350         


Lys Ala Ala Leu Ser Lys Phe Phe Glu 
        355                 360     


<210>  4
<211>  274
<212>  PRT
<213>  Pichia pastoris

<400>  4

Met Ser Ser Asp Ala Val Glu Gln Leu Glu Asn Phe Gln Leu Ile Lys 
1               5                   10                  15      


Phe Asp Arg Phe Asp Pro Ser Thr Gln Ser Thr Ile Arg Ile Ala Arg 
            20                  25                  30          


Ser Pro Lys Pro Ile Pro Val Lys Val Val Ile Val Gly Asp Gly Gly 
        35                  40                  45              


Cys Gly Lys Thr Cys Leu Leu Asn Val Phe Ala Thr Gly Thr Phe Pro 
    50                  55                  60                  


Glu Ala Tyr Val Pro Thr Ile Ile Glu Asn Val Val Ile Thr Leu Val 
65                  70                  75                  80  


Thr Pro Thr Gly Gln Ile Ala Ala Val Thr Leu Trp Asp Thr Ala Gly 
                85                  90                  95      


Gln Glu Glu Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Ser Asp Val Asp 
            100                 105                 110         


Val Val Leu Leu Cys Tyr Ser Ile Asp Asn Leu Ser Thr Phe His Asn 
        115                 120                 125             


Val Ala Asp Lys Trp Tyr Pro Glu Val Ala His Phe Cys Pro Asn Thr 
    130                 135                 140                 


Pro Ile Ile Leu Val Gly Thr Lys Ser Asp Met Arg Arg His Gln Lys 
145                 150                 155                 160 


Ser Gln Pro His Phe Val Ser Pro Gln Asp Ser Ser Gln Leu Ala Arg 
                165                 170                 175     


Gln Met Gly Ala Val Met Asn Ile Glu Cys Ser Ala Lys Glu Val Ser 
            180                 185                 190         


Asn Val Asn Ile Val Phe Asp Ala Ala Val Ser Tyr Cys Leu Ser Asn 
        195                 200                 205             


Ser Arg Pro Lys Thr Arg Gly Asp Asn Asp Asn Asn Arg Ser Asn Arg 
    210                 215                 220                 


Arg Leu Ser Arg Ala Lys Arg Ala Ser Met Phe Ile Arg Gly Lys Asp 
225                 230                 235                 240 


Val Ser Ser Thr Ser Gly Asn Ser Arg Glu Glu Leu Val Glu Tyr Asp 
                245                 250                 255     


Gln Asp Gly Leu Ala Ile Ile Pro Asp Arg Lys Lys Arg Lys Cys Ser 
            260                 265                 270         


Ile Ile 
        


<210>  5
<211>  127
<212>  PRT
<213>  Pichia pastoris

<400>  5

Met Thr Asn Trp Lys Ala Ile Leu Thr Pro Ala Gln Tyr Gln Val Leu 
1               5                   10                  15      


Arg Leu Gly Gly Thr Glu Arg Pro Tyr Thr Gly Gln Tyr Val Asn Phe 
            20                  25                  30          


Lys Lys Asn Gly Thr Tyr Leu Cys Ser Gly Cys Gln Thr Pro Leu Tyr 
        35                  40                  45              


Lys Ser Gly Thr Lys Phe Asp Ser Ser Cys Gly Trp Pro Ala Phe Tyr 
    50                  55                  60                  


Glu Ala Leu Pro Gly Ala Val Lys Arg Ile Glu Asp Asn Ser Leu Gly 
65                  70                  75                  80  


Met Arg Arg Ile Glu Ile Arg Cys Ser Lys Cys Asp Gly His Leu Gly 
                85                  90                  95      


His Val Phe Glu Gly Glu Gly Phe Asp Thr Pro Thr Asp Ser Arg His 
            100                 105                 110         


Cys Val Asn Ser Ile Ser Leu Lys Phe Gln Gly Glu Glu Glu Asn 
        115                 120                 125         


<210>  6
<211>  1027
<212>  PRT
<213>  Pichia pastoris

<400>  6

Met Thr Thr Asn Gly Gln Lys Arg Gln Lys Thr Arg Lys Pro Leu Leu 
1               5                   10                  15      


Ile Asn Ala Phe Val Met Gly Cys Ala Gly Leu Gln Asn Pro Gly Leu 
            20                  25                  30          


Trp Lys His Pro Lys Asp Ser Ser His Arg Phe Asn Gln Ile Asp His 
        35                  40                  45              


Trp Thr Tyr Leu Ala Lys Leu Ala Glu Lys Gly Lys Phe Asn Ala Leu 
    50                  55                  60                  


Phe Ile Ala Asp Val Leu Gly Gly Tyr Asp Val Tyr Lys Gly Pro Glu 
65                  70                  75                  80  


Asn Leu Ala Thr Pro Ala Val Ala Gly Ala Gln Trp Pro Val Thr Glu 
                85                  90                  95      


Pro Ser Ala Val Val Ser Ala Met Ala Ala Val Thr Thr Asn Leu Ala 
            100                 105                 110         


Phe Gly Val Thr Phe Ser Thr Ile Ser Glu Ala Pro Tyr His Phe Ala 
        115                 120                 125             


Arg Arg Leu Ser Thr Leu Asp His Leu Thr Lys Gly Arg Ile Gly Trp 
    130                 135                 140                 


Asn Val Val Ser Ser Tyr Leu Glu Ser Ala Ala Arg Asn Leu Leu Asn 
145                 150                 155                 160 


Gly Glu Lys Leu Asp Glu His Asp Gln Arg Tyr Leu Lys Ala Glu Glu 
                165                 170                 175     


Tyr Ile Gln Ile Val Tyr Glu Leu Leu Leu Ser Ser Trp Arg Asp Asp 
            180                 185                 190         


Ala Val Val Leu Asp Lys Lys Ala Gly Val Tyr Thr Asp Pro Thr Arg 
        195                 200                 205             


Phe Arg Lys Ile Asn Phe Glu Gly Lys Phe Phe Lys Val Pro Gly Pro 
    210                 215                 220                 


His Ile Val Asp Pro Thr Pro Gln Arg Leu Pro Val Ile Leu Gln Ala 
225                 230                 235                 240 


Gly Thr Ser Lys Val Gly Lys Glu Phe Ala Ala Lys His Ala Glu Ile 
                245                 250                 255     


Val Phe Val Ile Ser Phe Ser Pro Asp Asp Leu Lys Pro Lys Ile Ala 
            260                 265                 270         


Glu Val Arg Gln Leu Ala Lys Glu Lys Phe Gly Arg Asn His Asp Asp 
        275                 280                 285             


Ile Lys Phe Val Ala Leu Ala Thr Pro Val Ile Gly Ala Thr His Glu 
    290                 295                 300                 


Leu Ala Glu Glu Lys Tyr Gln Glu Leu Leu Ser Tyr Gly Asp Ile Glu 
305                 310                 315                 320 


Gly Ala Gln Ala Leu Phe Gly Gly Trp Thr Gly Ile Asp Leu Ser Gln 
                325                 330                 335     


Tyr Gly Glu Asp Glu Glu Leu Gly Asn Val Ser Ser Asn Ala Met Arg 
            340                 345                 350         


Gly Ala Val Gln Asn Trp Thr Lys Ala Ile Pro Asn Glu Lys Arg Trp 
        355                 360                 365             


Thr Arg Lys Val Ile Ala Lys Gln Ile Thr Val Gly Gly Leu Gly Pro 
    370                 375                 380                 


Ala Phe Val Gly Thr Pro Glu Glu Ile Ala Asp Glu Leu Glu His Trp 
385                 390                 395                 400 


Ser Asp His Ala Gly Leu Asp Gly Phe Asn Phe Thr Tyr Ala Val Asn 
                405                 410                 415     


Pro Leu Ser Phe Glu Glu Ile Val Glu Asp Leu Ile Pro Val Leu Gln 
            420                 425                 430         


Arg Arg Gly Leu Ala Gln Lys Glu Tyr Pro Asn Pro Glu Thr Gly Ser 
        435                 440                 445             


Thr Phe Arg Lys Asn Leu Phe Gly Thr Asp Phe Val Pro Ser Thr His 
    450                 455                 460                 


Pro Ala Tyr Asn Leu Arg Trp Arg Ala Gly Val Ser Lys Glu Glu Phe 
465                 470                 475                 480 


Glu Lys Ser Leu Asn Ala Thr Thr Asn Trp Tyr Ser Ser Phe Ala Arg 
                485                 490                 495     


Ser Gly Ala Leu Gly Glu Leu His Asn Thr Cys Arg Ile Leu Tyr Leu 
            500                 505                 510         


Gln Ile Val Lys Tyr Lys Tyr Arg Leu Arg Val Arg Ser Glu Gly Asn 
        515                 520                 525             


Ser Ile Pro Phe Ala Lys Met Thr Lys Glu Asn Glu Ala Lys Arg Gln 
    530                 535                 540                 


Lys Thr Ser Gln Pro Lys Ala Lys Lys Gln Leu Ile Ile Asn Ala Phe 
545                 550                 555                 560 


Met Ser Gly Ser Ser Gly Asn Gln Ser Pro Gly Leu Trp Ser Tyr Pro 
                565                 570                 575     


Gly Asp Lys Ser Thr Glu Tyr Thr Thr Leu Asp Tyr Trp Val Glu Leu 
            580                 585                 590         


Ala Gln Lys Leu Glu Lys Ala Lys Phe His Ser Ile Phe Ile Ala Asp 
        595                 600                 605             


Val Leu Gly Gly Tyr Asp Val Tyr Asn Gly Pro Gly Asn Tyr Ser Ala 
    610                 615                 620                 


Ala Ala Lys Ser Gly Ala Gln Phe Pro Met Ile Glu Pro Ser Ala Ala 
625                 630                 635                 640 


Val Thr Ala Met Ala Ala Ala Thr Lys Ser Ile Thr Phe Gly Val Thr 
                645                 650                 655     


Phe Ser Thr Ile Ser Glu Ala Pro Tyr His Phe Ala Arg Arg Leu Gly 
            660                 665                 670         


Thr Leu Asp Leu Leu Thr Asn Gly Arg Val Gly Trp Asn Ile Val Ser 
        675                 680                 685             


Ser Tyr Leu Asp Ser Ala Ala Arg Asn Leu Leu Asn Gly Glu Pro Leu 
    690                 695                 700                 


Pro Leu His Ala Asp Arg Tyr Lys Arg Ala Glu Glu Phe Leu Gln Val 
705                 710                 715                 720 


Val Tyr Arg Leu Phe Leu Ser Ser Trp Arg Asp Asp Ala Tyr Lys Leu 
                725                 730                 735     


Asp Lys Lys Thr Arg Thr Phe Ala Asp Pro Lys Leu Ile Arg Thr Ile 
            740                 745                 750         


Asp His Val Gly Glu Phe Phe Asn Val Pro Gly Pro Gln Phe Leu Pro 
        755                 760                 765             


Pro Thr Pro Gln Arg Leu Pro Leu Ile Leu Gln Ala Gly Thr Ser Lys 
    770                 775                 780                 


Val Gly Met Asp Tyr Ala Ala Lys His Ala Glu Val Val Phe Leu Ala 
785                 790                 795                 800 


Ser Phe Asp Pro Glu Ser Leu Gln Glu Lys Ile Lys Thr Val Arg Asp 
                805                 810                 815     


Ile Ala Glu Thr Lys Tyr Asn Arg Pro Arg Asp Ser Ile Lys Phe Leu 
            820                 825                 830         


Ile Leu Ile Thr Val Val Ile Ala Asp Thr His Glu Asp Ala Val Lys 
        835                 840                 845             


Arg Tyr Glu Asp Leu Ala Ser Tyr Ala Asp Leu Glu Gly Ala Gln Ala 
    850                 855                 860                 


Leu Phe Ser Gly Trp Thr Gly Ile Asp Ile Gly Lys Tyr Gly Glu Asp 
865                 870                 875                 880 


Glu Pro Leu Glu His Val Glu Ser Asn Ala Ile Lys Ser His Val Lys 
                885                 890                 895     


Asn Trp Thr Lys Phe Lys Asp Asn Lys Pro Arg Ala Arg Lys Asp Ile 
            900                 905                 910         


Ala Lys Gln Ile Gly Val Gly Gly Ser Gly Pro Leu Leu Val Gly Ser 
        915                 920                 925             


Val Gln Glu Ile Ala Asp Glu Leu Glu Arg Trp Ala Glu Val Ser Asp 
    930                 935                 940                 


Leu Asp Gly Phe Asn Phe Ala Tyr Ala Asp Tyr Pro Gln Thr Phe Asp 
945                 950                 955                 960 


Asp Ile Ile Glu Lys Leu Leu Pro Glu Leu Asn Lys Arg Gly Val Phe 
                965                 970                 975     


Trp Asp Asp Tyr Lys Ile Pro Gly Gly Thr Phe Arg Glu Ser Val Phe 
            980                 985                 990         


Gly Arg Lys Phe Val Asp Lys Asp  His Pro Ala Tyr Asp  Leu Arg Trp 
        995                 1000                 1005             


Arg Ser  Asp Gln Thr Arg Glu  Glu Phe Glu Lys Lys  Leu Ala Glu 
    1010                 1015                 1020             


Leu Glu  Lys Lys 
    1025         


<210>  7
<211>  546
<212>  PRT
<213>  Pichia pastoris

<400>  7

Met Ser His Leu Leu Leu Arg Asp Ser Phe Trp Gly Arg Thr Ile Tyr 
1               5                   10                  15      


His Leu Ser Lys His Arg Tyr Phe Ser Phe Pro Glu Glu Lys Asp Gly 
            20                  25                  30          


Phe Ile Ala Pro Glu Lys Tyr Tyr Leu Asn Met Asp Gln Val Ser Ile 
        35                  40                  45              


His Ala Glu Ser Glu Lys Asn Ile Val Glu Gly Leu Val Asp Thr Ser 
    50                  55                  60                  


Asn Ser Ser Leu Glu Glu Val Lys Thr Thr Arg Val Ile Val Asp Trp 
65                  70                  75                  80  


Asp Glu Tyr Asp Gln Lys Glu Asn Pro Gln Asn Trp Ser Ser Leu Leu 
                85                  90                  95      


Lys Cys Phe Val Val Phe Glu Val Gly Ile Leu Thr Val Ala Val Tyr 
            100                 105                 110         


Met Gly Ser Ala Ile Tyr Thr Pro Gly Ile Glu Asp Ile Met Arg Asp 
        115                 120                 125             


Leu Asn Val Ser Arg Thr Val Ala Thr Leu Pro Leu Thr Leu Phe Val 
    130                 135                 140                 


Ile Gly Tyr Ala Val Gly Pro Met Ile Phe Ser Pro Met Ser Glu His 
145                 150                 155                 160 


Pro Ala Ile Gly Arg Thr Thr Ile Tyr Val Trp Thr Leu Phe Ile Phe 
                165                 170                 175     


Ala Ile Leu Gln Ile Pro Thr Ala Leu Thr Thr Asn Ile Ala Gly Phe 
            180                 185                 190         


Cys Ile Leu Arg Phe Ile Gly Gly Phe Phe Ala Ser Pro Ala Leu Ala 
        195                 200                 205             


Thr Gly Pro Ala Ser Val Gly Asp Val Ile Ala Ile Pro His Leu Pro 
    210                 215                 220                 


Val Gly Leu Gly Leu Trp Ser Ile Cys Ala Val Cys Gly Pro Ser Leu 
225                 230                 235                 240 


Gly Pro Leu Phe Gly Ala Ile Phe Ser Gln Leu Val Ser Trp Arg Trp 
                245                 250                 255     


Cys Phe Trp Phe Leu Leu Ile Thr Ser Gly Thr Leu Phe Ile Val Leu 
            260                 265                 270         


Gly Phe Thr Leu Pro Glu Thr Tyr Val Pro Thr Leu Leu Tyr Arg Lys 
        275                 280                 285             


Ala Arg Arg Leu Arg Ala Leu Thr Lys Asn Glu Leu Ile Ile Ser Lys 
    290                 295                 300                 


Gly Glu Leu Asp Ile Gln Asp Arg Thr Ala Lys Glu Val Leu Ile Glu 
305                 310                 315                 320 


Cys Leu Trp Arg Pro Val Asp Ile Ser Phe Arg Asp Pro Val Val Leu 
                325                 330                 335     


Met Ile Asn Leu Tyr Ile Ser Met Val Tyr Ser Ile Trp Tyr Ile Trp 
            340                 345                 350         


Phe Glu Ala Phe Pro Ile Val Phe Leu Glu Ile Tyr Gly Phe Ser Leu 
        355                 360                 365             


Ile Gly Met Gly Ala Ser Phe Ala Gly Ile Leu Ile Gly Val Leu Ile 
    370                 375                 380                 


Cys Ser Ala Cys Tyr Cys Tyr Ala Cys His Val Thr Phe Ala Arg Arg 
385                 390                 395                 400 


Ile Ile Ala Asn Glu Thr Ile His Pro Glu Phe Phe Val Pro Gly Ala 
                405                 410                 415     


Ile Ile Gly Gly Cys Ile Met Pro Thr Gly Ile Phe Ile Leu Gly Trp 
            420                 425                 430         


Thr Ala Thr Lys Ser Val His Trp Ile Val Pro Ile Ile Gly Ser Gly 
        435                 440                 445             


Leu Phe Ala Ala Gly Gly Tyr Leu Ile Phe Gln Thr Leu Phe Asn Tyr 
    450                 455                 460                 


Leu Ala Met Ser Phe Pro Arg Tyr Met Ala Ser Ala Phe Ala Gly Asn 
465                 470                 475                 480 


Asp Leu Phe Arg Ser Phe Ser Ala Ser Val Phe Pro Leu Phe Gly His 
                485                 490                 495     


Ala Leu Tyr Ala Asn Leu Gly Ser Glu Lys Phe Pro Val Gly Trp Gly 
            500                 505                 510         


Ser Ser Val Leu Gly Phe Ile Thr Val Ala Met Ile Ala Ile Pro Val 
        515                 520                 525             


Thr Phe Met Arg Tyr Gly Pro Arg Leu Arg Ala Asn Ser Arg Tyr Ala 
    530                 535                 540                 


Gly Pro 
545     


<210>  8
<211>  355
<212>  PRT
<213>  Pichia pastoris

<400>  8

Met Thr Asp Tyr Val Thr Ser Lys Arg Pro Asp Asn Val Leu Asn Trp 
1               5                   10                  15      


Thr Ser Ile His Val Ser Ser Trp Ile Gly Glu Thr Ile Pro Glu Ile 
            20                  25                  30          


Asp Pro Ser Leu Leu Gln Asn Phe Leu Glu His Asp Ile Ala Gly Asp 
        35                  40                  45              


Val Leu Pro Tyr Leu Lys Ser Glu Asp Leu Lys Glu Ile Gly Ile Asn 
    50                  55                  60                  


Glu Leu Lys His Arg Ile Ser Ile Lys Lys Asn Ile His Glu Leu Leu 
65                  70                  75                  80  


Val Ser Asn Glu Lys His Ile Asp Thr Ser Ile Leu Ser Asp Thr Ala 
                85                  90                  95      


Thr Glu Leu Gly Thr Leu Ile Leu Thr Asn Lys Phe Ile Thr Gln Met 
            100                 105                 110         


Ala Asn Arg Lys Asn Val Val Asp Asp Ser Thr His His Ser Asn Asn 
        115                 120                 125             


Arg Arg Leu Thr Glu Gln Phe Asn Lys Leu Arg Lys Asp Leu Leu Pro 
    130                 135                 140                 


Ile Phe Lys Trp Ile Lys Glu Thr Gln Pro Leu Pro Thr Pro Glu Asn 
145                 150                 155                 160 


Thr His Phe Ala Asn Met Gly Ser Val Pro Ala Ser Pro Val Glu His 
                165                 170                 175     


Thr Ser Gly Glu Ser Thr Leu Ser Asn Pro Ser Leu Ser Thr Ile Asn 
            180                 185                 190         


Ala Gly Glu Gly Val Asn Ser Ala Val Ala Gly Gln Ser Leu Gly Arg 
        195                 200                 205             


Lys Pro Thr Leu Ser Ser Arg Arg Gln Ser His Ala Leu Ser Pro Thr 
    210                 215                 220                 


Gly Glu His Leu Asn Val Ser Ser Ser Ser Pro Ser Thr Gly Asn Phe 
225                 230                 235                 240 


Glu Thr Leu Asn Gly Glu Arg Pro Asn Leu Arg Ser Ala Ser Ser Gly 
                245                 250                 255     


Ser Gln Glu His Thr Glu Asn Glu Leu Leu Lys Pro Leu Arg Val Lys 
            260                 265                 270         


Ala Asp Glu Pro Cys Tyr Lys Val Ile Gln Asn Ala Met Lys Arg His 
        275                 280                 285             


Gly Leu Ser Val Asp Asp Trp Arg Lys Tyr Ala Leu Val Ile Cys Tyr 
    290                 295                 300                 


Gly Asp Glu Glu Arg Val Leu Gly Leu His Glu Lys Pro Gly Ser Ile 
305                 310                 315                 320 


Phe Lys Glu Leu Lys Asp Gln Lys Gln Asn Pro Ala Ile Met Leu Arg 
                325                 330                 335     


Gln Ile Asp Thr Asn Asn Asp Asp Gln Asn His Ile Glu Thr Pro Gly 
            340                 345                 350         


Gly Arg Leu 
        355 


<210>  9
<211>  194
<212>  PRT
<213>  Pichia pastoris

<400>  9

Met Arg Phe Ser Asn Val Val Leu Thr Ala Ile Ala Ala Ala Gly Val 
1               5                   10                  15      


Gln Ala Asp Glu Ala Leu Tyr Thr Val Phe Tyr Asn Asp Val Thr Glu 
            20                  25                  30          


Asn Ala Gln Glu Tyr Leu Ser Tyr Ile Gln Ala Asn Thr Ala Ala Gly 
        35                  40                  45              


Phe Thr Asp Leu Leu Ser Leu Tyr Thr Glu Leu Ala Thr Tyr Thr Asp 
    50                  55                  60                  


Asp Ser Tyr Thr Ser Ile Phe Thr Glu Glu Asp Phe Pro Ala Ser Glu 
65                  70                  75                  80  


Leu Ser Ser Phe Val Val Asn Leu Pro Trp Tyr Ser Ser Arg Ile Glu 
                85                  90                  95      


Pro Gln Val Ala Ala Ala Glu Thr Gly Glu Ser Glu Glu Glu Ser Glu 
            100                 105                 110         


Thr Gly Glu Ser Glu Glu Glu Ser Glu Thr Gly Glu Glu Thr Glu Thr 
        115                 120                 125             


Glu Thr Gly Ser Glu Ser Glu Ser Glu Ser Glu Ser Glu Thr Ser Ala 
    130                 135                 140                 


Thr Gly Thr Gly Thr Gly Thr Ser Ala Ser Glu Ser Ala Glu Thr Glu 
145                 150                 155                 160 


Thr Ser Thr Asp Ala Ala Val Ser Ile Asp His Pro Lys Ser Thr Leu 
                165                 170                 175     


Leu Met Gly Leu Thr Ala Ala Val Val Ser Ile Thr Phe Gly Val Phe 
            180                 185                 190         


Ala Leu 
        


<210>  10
<211>  806
<212>  PRT
<213>  Pichia pastoris

<400>  10

Met Asn Lys Pro Asn Gly Ser Glu Gln Gln Pro Pro Ser Arg Gly Met 
1               5                   10                  15      


Lys Gln Glu Ser Gly Gly Pro Val Thr Ser Ser Thr Thr Pro Gly Thr 
            20                  25                  30          


Asn Thr Gly Leu Glu Asn Ser His Ser Met Gly Ala Asp Met Glu Pro 
        35                  40                  45              


Asp Val Gly Ala Thr Ser Pro Arg His Leu Leu Asn Gly Tyr Ile Tyr 
    50                  55                  60                  


Asp Tyr Leu Val Lys Ser Asn Met Gln Asn Leu Ala Asp Gln Phe Ala 
65                  70                  75                  80  


Gln Glu Thr Glu Leu Leu Glu Thr Asp Leu Thr Val Pro Met Asp Thr 
                85                  90                  95      


Pro Ser Gly Tyr Leu Leu Glu Trp Trp Met Val Phe Trp Asp Leu Phe 
            100                 105                 110         


Asn Ala Arg Leu Lys Gln Arg Gly Ser Gln Lys Ala His Gln Tyr Ile 
        115                 120                 125             


Gln Leu Asn Met Leu Arg Gln Gln Gln Gln Arg Thr Met Arg Asn Thr 
    130                 135                 140                 


Ala Arg Val Gln Lys Val Pro Leu Arg Pro His Thr Gln Ser Ser Pro 
145                 150                 155                 160 


Ser Met Ser Gln Thr Phe Ile Pro Gln Gln Pro Gln Gln Gln Ala Gln 
                165                 170                 175     


Gly Gln Gln His Ala Gln Ala Gln Ala Gln Val Gln Ala His Gln Gln 
            180                 185                 190         


Ala Gln His His Ala Gln Ala Gln Val Pro Val Gln Pro Gln Gln His 
        195                 200                 205             


Gln Leu Gly Gly Gln Thr Gln Gln Gln Gln Ser Ile Asn Thr Gly Ser 
    210                 215                 220                 


Pro Ala Gly Pro Asn Ala Ile Asn Ser Arg Val Gln His Leu Ala Gln 
225                 230                 235                 240 


Gln Gln Met Asn His Leu Arg Gln Gln Ala Thr Ala Thr Thr Gln Gln 
                245                 250                 255     


Pro Ile Pro Gln Gln Asn Ile Pro Ser Asn Gln Gln Gly Pro Thr Gly 
            260                 265                 270         


Pro Tyr Pro Thr Ser Pro Ser Arg Arg Pro Arg Leu Leu Ser Asn Glu 
        275                 280                 285             


Ser Gly Ala Ser Ala Pro Ser Val Met Thr Lys Ser Gln Leu Gln Gly 
    290                 295                 300                 


Val Pro Pro Ser Gln Gln Pro His Gln Gln Gln Gly Gln Gln Val Gly 
305                 310                 315                 320 


Pro Pro Asn Gln His Gln Gly Gln Ser Ser Ser Phe Tyr Ser Gly Met 
                325                 330                 335     


Pro Pro Gln Gly Val Val Val Pro His Gln Phe Asn Pro Gln Gln Tyr 
            340                 345                 350         


Ala Asn Met Leu Ala Arg Gln Gln His Val Gln Ala Gln Gln Gln Val 
        355                 360                 365             


Gln Leu Gln Gln Val Gln His Val Gln Gln Arg Gln Gln Gln Asp Gln 
    370                 375                 380                 


Gln Gln His Arg Leu Ser Ala Gly Ser Pro Gly His Pro Ser Phe Gly 
385                 390                 395                 400 


Val Phe Gln Gln Pro Pro Pro Met Ser Asn His Asn Gln Val Met Ile 
                405                 410                 415     


Asn Gln Gln Gly Glu Thr Phe Phe Asp Pro His Ser Pro Tyr Ala Gln 
            420                 425                 430         


Pro Asn Gly Tyr Pro Gln Pro Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        435                 440                 445             


Gln Gln Gln Gln Gln Gln Pro Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    450                 455                 460                 


Gln Lys Gln Gln Pro Pro Pro Pro Pro Arg Gln Pro Gln Arg Gln Gln 
465                 470                 475                 480 


Ala Met Ala Met Ala Pro Leu Pro His Ser Thr Ser Ala Ala Gly Thr 
                485                 490                 495     


Pro His Ser Ser Thr Thr Pro Arg Phe Ser Gln Pro Gly Pro Val Tyr 
            500                 505                 510         


Gln Gln Pro Leu Pro Ala Ser Gln Pro Gln His Ser Pro Pro Ser Ser 
        515                 520                 525             


Ile Gln Gln Pro Glu Leu Val Pro Thr Pro Gly Ser Gln His Gln Gln 
    530                 535                 540                 


Ile Ala Gln Pro Gln Ser Gln Ser Gln His Gln Gln Ser Gln Gln Ser 
545                 550                 555                 560 


Gln Ser Ser Ala Ser Lys Ile Val Gly Ile Gln Glu Tyr Gln Lys Glu 
                565                 570                 575     


Leu Met Met Leu Glu Lys Gln Asn Lys Gln Arg His Asp Met Ala Cys 
            580                 585                 590         


Lys Lys Gly Ser Gly His Phe Ser Asn Phe Asp Pro Ile Pro Glu His 
        595                 600                 605             


Thr Pro Pro Glu Pro Lys Phe Asn Val Asn Val Met Leu Pro Pro Gln 
    610                 615                 620                 


Asn Ser Ala Val Val Thr Lys Asn Thr Pro Gly Thr Ser Pro Gly Thr 
625                 630                 635                 640 


Gln Thr Gln Asn Thr Ala His Ser Thr Gly Asn Thr Ser Ala Gly Ser 
                645                 650                 655     


Thr Pro Asn Asn Val Ala Pro Val Arg Lys Lys Lys Glu Pro Ala Lys 
            660                 665                 670         


Lys Lys Ala Lys Lys Ala Thr Glu Pro Pro Thr Pro Thr Thr Pro Gln 
        675                 680                 685             


Thr Pro Ile Ala Ala Arg Thr His Gln Asn Ser Thr Gly Gly Ile Pro 
    690                 695                 700                 


Gly Asn Asn Ala Ala Thr Lys Arg Arg Lys Arg Glu Pro Leu Val Asp 
705                 710                 715                 720 


Gln Thr Val Ser Pro Asn Leu Asn Glu Ala Ser Lys Ser Thr Lys Thr 
                725                 730                 735     


Gly Lys Ile Ser Ser Gln Thr Asp Phe Thr Gly Ser Asp Asn Gly Phe 
            740                 745                 750         


Leu Gln Asp Phe Gly Asp Gly Thr Gly Pro Pro Thr Gly Thr Asp Asp 
        755                 760                 765             


Met Glu Phe Asp Phe Asn Ser Phe Leu Asn Asn Glu Thr Gly Glu Pro 
    770                 775                 780                 


Asn Ser Ser Thr Ile His Phe Asp Asn Val Phe Asn Trp Gly Glu Gly 
785                 790                 795                 800 


Thr Glu Ala Gly Asp Leu 
                805     


<210>  11
<211>  149
<212>  PRT
<213>  Pichia pastoris

<400>  11

Met Val Val His Asn Pro Asn Asn Trp His Trp Val Asp Lys Asn Cys 
1               5                   10                  15      


Leu Pro Trp Ala Lys Ser Tyr Phe Gln Glu Val Leu Pro Asn Thr Thr 
            20                  25                  30          


Gln Lys Asn Asp Ala Tyr Glu Ile Val Val Thr Ser Val Asp Leu Val 
        35                  40                  45              


Asp Gly Asp Cys Asp Val Thr Gln Arg Lys Gly Val Thr Lys Cys Ile 
    50                  55                  60                  


Phe Asp Leu Lys Ile Gln Val Ser Ala Thr Val Lys Val Asn Thr Asn 
65                  70                  75                  80  


Ser Glu Val Glu Glu Ile Ser Tyr Thr Val Thr Leu Pro Glu Leu Val 
                85                  90                  95      


His Asp Gln Asp Glu Asp Glu Tyr Glu Tyr Val Ile Glu Gly Asn Leu 
            100                 105                 110         


Asp His Lys Ser Gln Ile Arg Lys Leu Leu Thr Pro Leu Leu Thr Glu 
        115                 120                 125             


Lys Leu Ser Lys Phe Gln Gln Ala Leu Ile Asp Ala His Thr Gln Asp 
    130                 135                 140                 


Val Gln His Ser Thr 
145                 


<210>  12
<211>  354
<212>  PRT
<213>  Pichia pastoris

<400>  12

Met Lys Ile Trp Leu Val Leu Leu Leu Val Phe Ala Thr Val Phe Ala 
1               5                   10                  15      


Glu Thr Asp Tyr Tyr Lys Val Leu Gly Val Ala Lys Asn Ala Asp Glu 
            20                  25                  30          


Lys Asp Ile Lys Lys Ala Tyr Arg Ser Leu Ser Lys Lys Phe His Pro 
        35                  40                  45              


Asp Lys Asn Pro Gly Asp Asp Glu Ala Ala Gln Lys Phe Ile Gln Val 
    50                  55                  60                  


Gly Glu Ala Tyr Asp Val Leu Gly Asp Pro Glu Lys Arg Gln Arg Tyr 
65                  70                  75                  80  


Asp Arg Phe Gly Ala Glu Gly Leu Asp Ser Arg Gln Glu Gln Phe His 
                85                  90                  95      


Asp Pro Phe Asp Met Phe Gln Gln Phe Phe Gly Gly Gly Gly Gln Gln 
            100                 105                 110         


His Arg Gly Lys Pro Lys Gly Lys Ser Ser Leu Leu His Leu Glu Phe 
        115                 120                 125             


Ser Leu Gln Asp Phe Tyr Asn Gly Ala Ser Asn Asp Phe Arg Ile Glu 
    130                 135                 140                 


Met Gln Asn Ile Cys Glu Thr Cys Ser Gly Ser Gly Ser Gln Asp Gly 
145                 150                 155                 160 


Lys Val His Gln Cys Asp Thr Cys Lys Gly His Gly Arg Val Val Gln 
                165                 170                 175     


Thr Arg Gln Phe Gly Gly Gly Met Gln Gln Arg Phe Glu Thr Ile Cys 
            180                 185                 190         


Pro Lys Cys Ser Gly Thr Gly Asn Leu Ile Thr His Lys Cys Lys Lys 
        195                 200                 205             


Cys Gln Gly Asn Arg Val Val Arg Gly Pro Arg Ile His Asn Val His 
    210                 215                 220                 


Leu Gly Ala Gly Thr Ser Arg Asn His Val Glu Ile Leu Glu Gly Gln 
225                 230                 235                 240 


Gly Asp Gln Ser Pro Asp Trp Ile Ala Gly Asp Leu Gln Ile Met Phe 
                245                 250                 255     


Lys Glu Lys Ala Glu Gly Asn Met Gly Tyr Arg Arg Ile Gly Asn Asn 
            260                 265                 270         


Leu Tyr Arg Asp Glu Ala Leu Thr Leu Lys Glu Ala Leu His Gly Gly 
        275                 280                 285             


Trp Glu Arg Gln Ile Ala Phe Leu Asp Lys Ile Glu Asn Thr Ile Thr 
    290                 295                 300                 


Leu Ser Lys Lys Lys Gly Glu Val Val Val Asp Gly Gln Val Asp Thr 
305                 310                 315                 320 


Ile Lys Gly Arg Gly Met Pro Leu His Asp His Tyr Asp Glu His Gly 
                325                 330                 335     


Asp Leu Phe Ile Lys Tyr His Ile Ile Tyr Pro Gln Gln Ile Arg Asp 
            340                 345                 350         


Glu Leu 
        


<210>  13
<211>  288
<212>  DNA
<213>  Pichia pastoris

<400>  13
atgttaaaca agctgttcat tgcaatactc atagtcatca ctgctgtcat aggcgagacg       60

actacgtcat ctaccactgc cagtctctcc gaaagcccta ctctggtttg ggtgactggc      120

actgatgcaa gtgggagatt ggcaactaca cagtctgctt acactcaaca gttttcacag      180

ttatactcat ccatagcatc tccatcaagt ggtagcatag gcctgggtac tatccagggg      240

actgttggaa ttgtcagaac atatgagaca attacccttg ccagctaa                   288


<210>  14
<211>  261
<212>  DNA
<213>  Pichia pastoris

<400>  14
atgtctacag caattccagg aggacagaga acgttagcta aaagaagagc agcaaacttg       60

gataagaaac aggatgaacc aacctccgcc agatctgccg gtgctggagg ttcttcgtct      120

accatgctaa agttgtacac agacgaggcc caaggtttga aagttgatcc tttaattgtt      180

cttgttcttg ctgttggttt cattttcagt gtcattggtt tgcacgttgt tgctaagctg      240

acaggaaagt tgatcaacta a                                                261


<210>  15
<211>  1086
<212>  DNA
<213>  Pichia pastoris

<400>  15
atgactcccc gttctcatat tttctttgac atctccatca acaaccagcc agctggcaga       60

ataatctttg agctcttcaa tgacattgtt cctaagacag cagagaattt tagagcttta      120

tctactggtg agaaaggtat aggtaagtct gggaaaccat tgcactacaa gggttctact      180

ttccatagga tcattaagga ttttatggta caaggtggtg actttaccaa cggtaacggt      240

actggaggcg aatccatata tggagaaaaa tttgaagatg aaaatttcca attgactcat      300

gacaaaccgt tccttctctc tatggcaaac gctggaccag gaactaatgg atcccagttt      360

tttatcacca ccgttcctac tcctcatctg gataacaagc atgtagtgtt tggaaaagta      420

attgctggta aagccacagt tagaaagatt gaaagaaact ccgaaggtga agctccaatt      480

gaacccgttg tcattgagga ctgtggtgaa cttccagaag acgcagattt gaccatctcc      540

gacgagactg gagacaagta tgaggaagtt ctgaaagata atgagaacat agacatcgat      600

gactttgaac aggtctacca ggccatcact gaaatcaaag aattgggtac aaagtatttc      660

aaaaatggtg acaccaaaat cgccttcgaa aagtatcaaa aggctgctaa ttatttgctg      720

gaatacatac catcagattt atcagaggaa cagagctcta agttggagct gctaaaaaca      780

tctgtcttct ccaacgtggc attggctgga ctgaaagttt ccaagttcaa agacacgatt      840

aagtatgcca cattggtcat tgaggatgaa tctgcggatg caaaggccaa gtccaaaggc      900

tactaccgta gaggaagtgc ttacagctca ctgaaagacg aagattcagc catctcagat      960

ttccagaaag cacttgaatt atccccaggt gatcctgcaa ttagccaatc tctacaaaga     1020

accacgaagg ccagaaaaga ccgtcttgcc aaagagaaag ctgctttgtc taagttcttt     1080

gagtag                                                                1086


<210>  16
<211>  825
<212>  DNA
<213>  Pichia pastoris

<400>  16
atgtcgtctg atgctgtgga gcaacttgaa aacttccagt tgatcaagtt cgacagattc       60

gatccttcaa cgcaatcgac tatcagaata gcgcgatctc ccaaaccaat tccagtcaag      120

gttgtgatag tgggagatgg tggatgtgga aagacatgtc ttctcaatgt ctttgccact      180

ggaacgtttc ctgaggcgta tgtccccaca atcatagaaa atgtggttat tacattggtg      240

accccaactg gccagatagc tgccgttact ctgtgggata ctgcagggca agaagagtac      300

gacagattga gacccctaag ctactccgac gttgacgtgg tcttgctgtg ctacagcata      360

gacaatctgt ccacctttca taatgtggcc gacaaatggt acccagaagt ggcacatttt      420

tgtccaaaca caccgatcat cttggtaggt accaaatctg atatgcggcg tcatcagaag      480

agtcagccgc actttgtatc tccccaggat tcgtcgcagt tggcaaggca gatgggggca      540

gtgatgaaca tcgagtgttc tgcgaaggag gtttcaaacg tcaatatcgt ttttgatgct      600

gctgtgtcgt actgtttgag taacagcagg cccaagacca gaggggataa tgacaacaat      660

aggagtaaca gacggctaag tagagccaag cgagccagca tgtttataag gggtaaggat      720

gttagctcaa cgtcaggaaa ctctcgggaa gaacttgttg aatacgatca agatgggttg      780

gcaataatac cggacagaaa gaaacgcaaa tgtagcatta tttga                      825


<210>  17
<211>  384
<212>  DNA
<213>  Pichia pastoris

<400>  17
atgactaact ggaaagcgat attgactccc gctcaatacc aagtcctccg tttgggcgga       60

acagaaagac cgtataccgg acagtatgtg aacttcaaga aaaatggaac ctacttgtgt      120

agtgggtgtc aaactccgct ttacaaaagt ggcacaaaat ttgattcatc ttgtggttgg      180

cctgcattct atgaagcatt acctggagca gttaaacgaa tagaagacaa ttcgcttgga      240

atgcgaagaa tagaaatcag atgctccaaa tgtgatggac atcttggcca tgtttttgag      300

ggtgagggat ttgacactcc aacagattcc agacattgtg tcaacagcat cagcctaaaa      360

tttcaaggtg aagaagagaa ctaa                                             384


<210>  18
<211>  3084
<212>  DNA
<213>  Pichia pastoris

<400>  18
atgactacaa acggccagaa aagacaaaaa actcgcaaac cacttttgat caacgcattt       60

gtcatgggat gtgctgggtt acagaatcct ggtttatgga agcatcccaa ggactcatcc      120

catagattta atcagattga tcactggact tatttggcca agttagccga aaaggggaag      180

tttaatgcgc tcttcattgc cgacgtcttg ggtggctatg atgtctacaa aggacctgag      240

aatttagcca ctcctgctgt ggctggagcc cagtggcctg tcaccgagcc cagtgctgtg      300

gtctccgcca tggctgcagt cacaactaac ttggcgtttg gagtgacgtt ctctactatc      360

agcgaagccc cctatcattt tgccagaaga ctgtccactt tagaccactt gaccaagggt      420

agaataggat ggaatgttgt ttcatcttac ttggagagtg ctgctcgtaa cctcttgaat      480

ggtgaaaaat tggacgagca tgaccaaaga tacttgaaag ctgaagagta cattcaaata      540

gtttatgagc tgttgttatc gtcttggaga gatgatgcag tagttttaga caagaaagct      600

ggtgtttata ctgacccaac aagatttcga aagatcaact ttgaaggtaa atttttcaaa      660

gttccgggac cacatattgt tgaccccacc cctcaaagac tgcctgtgat tcttcaagct      720

ggtacttcta aagttggtaa ggagtttgct gctaagcatg ccgagattgt gtttgtcatt      780

tcattttctc cagatgattt gaaacccaag attgcagaag ttcgtcaact ggccaaagaa      840

aagtttggta gaaaccacga cgatattaag tttgttgccc ttgcaacccc tgttattgga      900

gccacacatg aactagctga agaaaagtac caagagttac taagttatgg tgatattgaa      960

ggtgctcaag ccttatttgg agggtggact ggcattgacc tctctcaata tggcgaagat     1020

gaagaactag gaaatgttag ttccaatgct atgcgtggcg ctgtacaaaa ctggactaaa     1080

gcaattccaa atgagaagcg ttggacacgt aaggttattg ctaaacagat taccgttggt     1140

ggtctaggtc cagctttcgt tggaacccca gaagaaatcg ccgatgagct ggaacactgg     1200

tccgaccacg ctggtttgga cggattcaac ttcacttatg ctgtcaaccc gctttctttc     1260

gaagagatag tggaagactt gattccagtt cttcagcgaa gagggttggc ccaaaaggaa     1320

tacccaaatc cagaaactgg aagcacattc cgtaaaaacc tttttggaac agactttgta     1380

ccatctaccc acccagctta taacttaaga tggagggctg gtgtgtccaa ggaagaattc     1440

gaaaagtccc taaacgccac aacaaattgg tattccagtt tcgctaggtc aggtgctcta     1500

ggtgaattgc ataatacatg caggattctc tatctccaaa tagtgaaata taaatatagg     1560

cttcgagtcc gttcagaagg gaatagcatc cccttcgcca aaatgaccaa ggaaaatgaa     1620

gccaagaggc agaaaacctc tcaaccaaaa gcgaagaagc aattgattat caatgctttc     1680

atgtcaggct cttcgggtaa ccaatcgcca ggactgtggt cgtaccctgg agacaaatca     1740

acagagtata ctaccctaga ttactgggtg gagttagctc aaaagctgga aaaggccaaa     1800

ttccattcta tcttcattgc cgatgttctg ggtggatatg acgtttacaa tggacctgga     1860

aactacagtg ctgctgcaaa atctggtgcc caatttccaa tgattgaacc aagtgctgca     1920

gttactgcca tggctgctgc taccaagtca ataacgttcg gagtgacttt ttccactata     1980

agtgaggcac cttatcattt tgcaagaaga ttgggaactt tagatctgct gacaaacgga     2040

agagtcggct ggaatatcgt ctcttcgtat cttgacagtg ccgccagaaa tcttttgaat     2100

ggagaaccac tccctctcca tgcagaccgt tataagagag ccgaagaatt cctacaagtt     2160

gtatatcggt tattcctttc ttcatggaga gacgatgctt ataaattgga taagaaaacc     2220

agaacctttg ctgacccaaa acttattaga actatcgacc acgttggaga gttcttcaat     2280

gtcccaggcc cccagttcct accacccact cctcagagac taccgctgat tttgcaggct     2340

ggtacttcca aggttggtat ggattatgct gcaaaacatg cagaggttgt ctttttagct     2400

tcatttgacc cagagtcact ccaagaaaaa atcaaaacag tgagagatat cgctgaaacc     2460

aagtacaaca gaccaagaga ttcaatcaaa ttcttaattt tgataacagt agtcatagct     2520

gatacacacg aagatgccgt gaagagatac gaagatctcg ccagttatgc tgatctggaa     2580

ggggcccaag cactgttcag tggttggact ggaatagata ttggaaagta tggtgaagat     2640

gaacctcttg agcatgtgga atctaacgct attaagagcc atgttaagaa ctggactaag     2700

ttcaaggaca ataagcctag agccagaaaa gatatcgcta aacagattgg agttggaggc     2760

tcaggtccct tacttgttgg atctgtacaa gagatagccg acgagcttga gagatgggca     2820

gaagtctctg acctcgatgg ctttaacttc gcttacgcag attaccccca aacttttgat     2880

gatatcattg aaaaactgct tccagagttg aacaagagag gtgtgttctg ggatgattat     2940

aaaattccag gtggaacctt cagagagagc gtgtttggaa gaaagttcgt tgataaggat     3000

catcctgctt atgatctgag atggagaagt gaccaaacta gggaggagtt tgaaaagaaa     3060

ctggctgaat tggagaaaaa ataa                                            3084


<210>  19
<211>  1641
<212>  DNA
<213>  Pichia pastoris

<400>  19
atgtctcatc tattactgcg tgacagcttt tggggaagga ccatctacca tctgagtaaa       60

cacaggtatt tctcttttcc tgaagagaaa gatggtttca ttgctcctga aaagtactac      120

ctgaatatgg accaagtatc gatacatgct gaatctgaga aaaatatagt ggaaggtttg      180

gtagacactt caaattcttc gttggaggaa gtaaagacca ctagagtcat agtcgactgg      240

gatgaatatg atcagaaaga aaatccccaa aactggagct cgcttttaaa gtgcttcgtt      300

gtttttgaag tgggaatctt aaccgtagct gtttatatgg gatctgcaat ttacactccc      360

ggtatagaag atattatgag agatctcaat gttagcagaa cggtggcaac acttccatta      420

accttgtttg tgattggata cgctgtgggt ccaatgatat tctcccccat gtctgagcat      480

cccgctatcg gaaggacaac gatatatgtg tggaccctgt tcatatttgc tatactacaa      540

atcccaacgg ccctgaccac taacattgct ggattttgca ttttgaggtt tattggaggg      600

ttttttgcgt caccagcatt agctacaggt ccagcttctg taggtgatgt tattgcaatc      660

ccgcacttgc ctgtagggtt aggcctttgg agtatctgtg ctgtttgtgg tccttctcta      720

ggaccacttt ttggagccat attttcccaa cttgtgagtt ggaggtggtg cttctggttt      780

ctgttaatta cctctgggac actatttata gttcttggct tcactttacc agaaacgtat      840

gtaccaaccc ttctttacag aaaggctagg aggctacgag cattaacaaa aaacgaactg      900

attatcagca aaggggagtt agatattcag gacagaactg ccaaggaagt tttgattgaa      960

tgcttatgga ggccagtcga catatcattc agagaccccg ttgtcttgat gataaatctt     1020

tacatttcaa tggtttattc tatttggtac atttggtttg aagcgtttcc tattgtattc     1080

ttagagatat atggattcag ccttattgga atgggagcta gttttgccgg aatcttaatt     1140

ggtgtcttaa tatgctctgc gtgctattgc tatgcgtgtc atgttacttt tgcaagaaga     1200

ataattgcaa acgaaaccat tcatcctgag ttctttgtac cgggcgctat tattggaggt     1260

tgcataatgc ccactggaat ctttattttg ggatggactg ccaccaaaag tgtccactgg     1320

attgtaccta taataggtag cggtttattt gctgctggtg gttatctcat tttccagaca     1380

ctcttcaact accttgcaat gtctttccct agatacatgg catcagcttt tgccggaaat     1440

gatcttttca ggtccttttc tgccagtgtt ttcccactgt ttggacatgc actatatgcc     1500

aacttgggat ccgaaaagtt ccctgttggt tggggttctt ctgtactggg gttcatcact     1560

gttgcaatga tcgcaattcc agtaactttc atgagatatg gtccaagatt gcgtgcaaat     1620

tctagatatg ccgggccatg a                                               1641


<210>  20
<211>  1068
<212>  DNA
<213>  Pichia pastoris

<400>  20
atgacggact atgtcacttc taagcggcca gataacgtgc tcaattggac aagtattcat       60

gtatcgtcct ggatagggga gactattcct gagatcgatc caagtctact ccaaaatttt      120

ttagaacatg acattgcggg agatgttcta ccctacttga agtctgaaga tctgaaggaa      180

attgggatca acgagctcaa gcacagaatc tctataaaaa agaacattca tgaacttctt      240

gtgagcaatg aaaagcacat tgataccagt attctatcag acaccgctac cgagctagga      300

actttgatac tgactaataa attcataacc cagatggcga acagaaagaa tgttgtagat      360

gattccactc atcattcgaa taacagaagg ctcactgaac agtttaataa gcttcgcaaa      420

gatcttttgc cgatattcaa atggatcaag gagacccaac cattacccac tccagagaat      480

acacatttcg caaatatggg ttcagtacca gcatctcctg tggagcatac ttcaggtgag      540

tcaacattgt ctaaccccag tctaagcacc atcaatgctg gcgaaggagt gaactctgca      600

gttgcagggc aatctctcgg gaggaaacct acattatcct ccagaagaca atcacatgct      660

ttgtctccaa ctggtgaaca cctgaatgtg tcatcatcat ctccttcgac ggggaatttt      720

gaaactctga atggagaaag acccaatctt agatctgctt cgtcaggatc acaggaacat      780

actgagaacg aactattgaa gccgttgaga gttaaagcag atgagccttg ctataaggtg      840

attcagaatg ccatgaaaag acatggctta tcggtagatg attggcgcaa gtatgctttg      900

gtcatctgct atggagatga agaacgagta ctaggcttac atgaaaaacc tgggagtatc      960

ttcaaggaac tcaaagatca gaaacagaat cctgcaatca tgcttcgtca aattgacact     1020

aataatgacg atcagaacca tattgaaacc cctggaggga gattatga                  1068


<210>  21
<211>  585
<212>  DNA
<213>  Pichia pastoris

<400>  21
atgagatttt ctaacgtcgt tttaactgca attgccgctg ccggcgtaca ggcagatgaa       60

gccctttaca ctgtgttcta caatgatgtc actgagaacg cccaagagta tctgtcttac      120

atccaggcca atactgcggc tggtttcact gacctcttga gtctgtacac tgaactggcc      180

acttacaccg acgattctta cacaagtatc tttactgagg aggatttccc tgcgagcgaa      240

ctttcatcgt tcgttgttaa cctgccatgg tattcctcca gaattgagcc acaagttgcg      300

gctgctgaaa ctggtgaaag tgaggaggaa tcagagactg gtgaaagtga ggaagaatca      360

gagactggtg aggagacaga aactgagact ggatctgagt ctgaatctga gtctgaatcg      420

gagacctccg ctactggcac tggcactggc acctccgcct ctgagagcgc ggagactgaa      480

acttctaccg acgctgctgt gtctatcgat cacccaaagt ccaccttatt gatgggtttg      540

actgccgcag ttgtcagtat cactttcgga gtctttgcct tgtaa                      585


<210>  22
<211>  2421
<212>  DNA
<213>  Pichia pastoris

<400>  22
atgaacaagc caaacgggtc tgaacaacaa ccaccgtcac gcggaatgaa gcaagagtca       60

ggaggcccag ttacttcatc tacgacgccg ggtaccaata ctggcctaga aaactctcat      120

tccatggggg cggatatgga gcctgatgtt ggtgctacct ctcctcgcca tcttcttaat      180

gggtacattt acgattattt agtcaaatct aacatgcaaa atttggctga tcaatttgcc      240

caagagacgg agctcttaga aacagacttg acagtaccaa tggatacgcc ttcaggctat      300

cttctagaat ggtggatggt attctgggac cttttcaatg cccgcctaaa gcaacggggt      360

tcacagaagg cccaccagta tattcagttg aacatgctac gacaacagca acagaggacc      420

atgcgaaata cagcccgtgt tcaaaaagtc ccgttgaggc cacacaccca atcatctcct      480

tcaatgtcac agacttttat tccacagcag cctcaacagc aagcacaggg acaacagcac      540

gcccaggctc aagcccaagt gcaagcacat cagcaagccc aacaccacgc gcaggcacaa      600

gtgccagtgc aaccgcaaca gcaccagcta ggaggccaaa ctcaacagca gcaatccatt      660

aacactgggt ctcctgcggg tccaaatgct atcaactcgc gtgttcaaca cttagcacaa      720

caacagatga atcaccttcg ccagcaggcg actgccacta cgcaacaacc tatcccgcaa      780

cagaatatcc catcaaacca acagggtcct acaggccctt atcctacttc cccttcaaga      840

agaccgagat tactgtctaa cgaatcgggt gcaagtgcac cctctgtaat gacaaagtca      900

cagctccaag gagtccctcc ctcacaacaa ccacaccagc agcaaggtca gcaggtaggc      960

ccccctaatc aacatcaagg tcaatcttct tccttttatt cgggcatgcc tcctcaaggg     1020

gtcgtggttc ctcatcagtt caatcctcag cagtatgcca atatgctagc aagacaacag     1080

catgtacaag ctcaacaaca ggttcagtta caacaggtcc aacatgtaca acagagacaa     1140

cagcaagacc aacaacaaca ccgcctgtcc gccggttcac cggggcaccc ttcatttggc     1200

gtttttcaac aacctcctcc gatgtcaaac cataatcagg tcatgatcaa tcagcaggga     1260

gaaacttttt ttgatccaca ttctccatat gctcaaccta acgggtaccc ccagccacag     1320

caacaacaac aacaacagca acaacaacaa caacagcagc aaccgcaaca gcagcagcag     1380

cagcagcagc aacagaagca gcaaccacca ccaccaccac gacagcctca gcgccaacaa     1440

gcgatggcca tggctcctct gcctcactct acttctgccg ccggtactcc tcactcgtcc     1500

accacaccta gattctcgca acctggtcct gtttatcagc agcctttacc tgcatctcaa     1560

ccgcaacatt ctccgccttc ttctattcag cagccggagc tagttccaac tccagggtca     1620

caacatcagc aaatagcaca accacaatca cagagccaac accagcaatc gcaacagtct     1680

caatcaagtg cttctaaaat tgtaggtata caggagtatc agaaagagct aatgatgctt     1740

gagaaacaga acaaacagcg tcatgacatg gcatgtaaga agggaagcgg gcatttttct     1800

aactttgatc caattccaga gcacacaccg cccgaaccaa aatttaatgt gaatgtaatg     1860

ctccctcccc agaactctgc agtggtcacg aagaatactc ccggaacttc acctggtaca     1920

caaactcaaa acactgcaca tagtactggt aacacttctg cggggtctac accaaataat     1980

gtcgcacctg tacgaaagaa aaaggagcca gctaaaaaga aggcaaagaa agctactgag     2040

cccccgactc ccactactcc acagactcca attgcagcta ggacacatca aaactctaca     2100

ggcggcattc ctggtaataa tgctgctact aagcgacgaa aacgggagcc gctggttgat     2160

caaactgttt cacctaacct taacgaagct tccaagtcaa caaagaccgg aaaaatttca     2220

tctcaaactg actttacagg ttctgacaat ggattcttac aggattttgg cgatggaact     2280

ggtcctccca ctggaaccga tgatatggaa tttgatttta acagttttct taataacgaa     2340

actggcgaac ctaatagttc aaccattcat tttgacaatg tattcaattg gggagaaggt     2400

accgaagccg gagatttata g                                               2421


<210>  23
<211>  450
<212>  DNA
<213>  Pichia pastoris

<400>  23
atggtggtgc acaaccctaa taactggcac tgggtcgaca agaactgcct tccttgggcc       60

aaaagctact ttcaggaagt ccttccaaac accactcaga agaatgacgc ctatgaaata      120

gtggtaacat ctgtggacct tgtagatgga gactgcgatg tcactcaacg taaaggtgtt      180

accaaatgta tttttgatct gaagatacag gtatctgcaa ccgtcaaagt caacacgaac      240

agtgaagtag aggagatcag ttatacagtg acattacctg aactggtgca cgaccaggac      300

gaggatgaat atgaatacgt aatagaggga aatttggatc acaagtctca aattagaaag      360

ctactcactc ctctgttgac cgagaagtta tcaaagtttc aacaagcttt gatagacgct      420

catactcagg atgttcagca tagtacctag                                       450


<210>  24
<211>  1065
<212>  DNA
<213>  Pichia pastoris

<400>  24
atgaagatat ggctggtact tcttttagtt tttgccacgg tgtttgccga gacagattat       60

tataaagttc ttggagtagc taaaaatgcg gatgaaaaag atatcaagaa ggcctacaga      120

tcgttgagta agaagtttca tccagataag aacccgggtg atgatgaagc cgctcaaaag      180

ttcattcaag ttggagaagc ttatgatgtg cttggtgatc ccgagaagcg tcaaaggtat      240

gacagatttg gagcagaagg actggactca agacaggaac aattccatga tccatttgac      300

atgtttcaac agttcttcgg aggaggtgga cagcaacaca gaggcaaacc aaagggtaag      360

agttccttgt tacatttaga attcagtcta caagactttt acaatggtgc tagtaacgac      420

tttagaatcg aaatgcagaa tatctgtgaa acttgttctg gatcaggttc acaagacggg      480

aaagttcatc aatgtgacac ttgcaaaggg cacgggcgtg ttgttcaaac gagacagttt      540

ggtggtggca tgcaacagag gtttgaaaca atttgcccaa aatgttcagg aacaggaaat      600

ctgatcactc acaagtgtaa gaaatgccaa ggaaaccgtg tagttagagg acccagaatt      660

cacaatgtgc atttgggggc gggaactagt aggaaccatg ttgagatcct ggaaggtcag      720

ggagaccagt ctccagactg gattgcaggt gatctacaaa tcatgttcaa ggagaaagcc      780

gaaggcaaca tggggtatag aagaatagga aacaacctgt acagagacga agcattaacg      840

ctgaaagagg cattgcatgg tggctgggag agacaaattg cgtttttgga taaaatagag      900

aacacgatta ctctttccaa gaagaaagga gaggtggtag ttgacggcca agtagacacc      960

atcaagggta gagggatgcc attacatgac cactatgacg aacatggtga tctctttatc     1020

aagtaccata tcatttaccc gcaacaaatt agagacgaat tgtga                     1065


<210>  25
<211>  312
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  25

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu 
                85                  90                  95      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            100                 105                 110         


Thr Phe Ser His Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        115                 120                 125             


Gly Leu Glu Trp Val Ala Asn Ile Glu Gln Asp Gly Ser Glu Lys Tyr 
    130                 135                 140                 


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
145                 150                 155                 160 


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                165                 170                 175     


Ala Val Tyr Phe Cys Ala Arg Asp Leu Glu Gly Leu His Gly Asp Gly 
            180                 185                 190         


Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala 
        195                 200                 205             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
    210                 215                 220                 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
225                 230                 235                 240 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                245                 250                 255     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            260                 265                 270         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr 
        275                 280                 285             


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    290                 295                 300                 


Val Glu Ser Lys Tyr Gly Pro Pro 
305                 310         


<210>  26
<211>  299
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  26

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
                85                  90                  95      


Ser Ala Ser Val Gly Asp Arg Val Ile Leu Thr Cys Arg Ala Ser Gln 
            100                 105                 110         


Gly Val Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        115                 120                 125             


Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro 
    130                 135                 140                 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Pro Asp Phe Thr Leu Thr Ile 
145                 150                 155                 160 


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Phe 
                165                 170                 175     


Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            180                 185                 190         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        195                 200                 205             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    210                 215                 220                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
225                 230                 235                 240 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                245                 250                 255     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            260                 265                 270         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        275                 280                 285             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    290                 295                 


<210>  27
<211>  939
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  27
atgagattcc catctatttt caccgctgtc ttgttcgctg cctcctctgc attggctgcc       60

cctgttaaca ctaccactga agacgagact gctcaaattc cagctgaagc agttatcggt      120

tactctgacc ttgagggtga tttcgacgtc gctgttttgc ctttctctaa ctccactaac      180

aacggtttgt tgttcattaa caccactatc gcttccattg ctgctaagga agagggtgtc      240

tctctcgaga agagagaggt ccaattggtc caatctggtg gaggattggt tcaaccaggt      300

ggatctctga gattgtcttg tgctgcttct ggtttcacct tctctcacta ctggatgtca      360

tgggttagac aagctcctgg taagggtttg gaatgggttg ctaacatcga gcaagatgga      420

tcagagaagt actacgttga ctctgttaag ggaagattca ctatttcccg tgataacgcc      480

aagaactcct tgtacctgca aatgaactcc cttagagctg aggatactgc tgtctacttc      540

tgtgctagag acttggaagg tttgcatggt gatggttact tcgacttatg gggtagaggt      600

actcttgtca ccgtttcatc tgcctctacc aaaggacctt ctgtgttccc attagctcca      660

tgttccagat ccacctccga atctactgca gctttgggtt gtttggtgaa ggactacttt      720

cctgaaccag tgactgtctc ttggaactct ggtgctttga cttctggtgt tcacaccttt      780

cctgcagttt tgcagtcatc tggtctgtac tctctgtcct cagttgtcac tgttccttcc      840

tcatctcttg gtaccaagac ctacacttgc aacgttgacc ataagccatc caataccaag      900

gttgacaaga gagttgagtc caagtatggt ccaccttaa                             939


<210>  28
<211>  900
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  28
atgagattcc catctatttt caccgctgtc ttgttcgctg cctcctctgc attggctgcc       60

cctgttaaca ctaccactga agacgagact gctcaaattc cagctgaagc agttatcggt      120

tactctgacc ttgagggtga tttcgacgtc gctgttttgc ctttctctaa ctccactaac      180

aacggtttgt tgttcattaa caccactatc gcttccattg ctgctaagga agagggtgtc      240

tctctcgaga agagagctat ccagttgact caatcaccat cctctttgtc tgcttctgtt      300

ggtgatagag tcatcctgac ttgtcgtgca tctcaaggtg tttcctcagc tttagcttgg      360

taccaacaaa agccaggtaa agctccaaag ttgctgatct acgacgcttc atcccttgaa      420

tctggtgttc cttcacgttt ctctggatct ggatcaggtc ctgatttcac tctgactatc      480

tcatcccttc aaccagaaga ctttgctacc tacttctgtc aacagttcaa ctcttaccct      540

ttgacctttg gaggtggaac taagttggag atcaagagaa ctgttgctgc accatcagtg      600

ttcatctttc ctccatctga tgagcaactg aagtctggta ctgcatctgt tgtctgctta      660

ctgaacaact tctacccaag agaagctaag gtccaatgga aggttgacaa tgccttgcaa      720

tctggtaact ctcaagagtc tgttactgag caagactcta aggactctac ttactccctt      780

tcttccacct tgactttgtc taaggctgat tacgagaagc acaaggttta cgcttgtgag      840

gttactcacc aaggtttgtc ttctcctgtt accaagtctt tcaacagagg tgaatgctaa      900


<210>  29
<211>  303
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  29

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu 
                85                  90                  95      


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp 
            100                 105                 110         


Ser Ile Thr Ser Asp Tyr Trp Ser Trp Ile Arg Lys Phe Pro Gly Asn 
        115                 120                 125             


Arg Leu Glu Tyr Met Gly Tyr Val Ser Tyr Ser Gly Ser Thr Tyr Tyr 
    130                 135                 140                 


Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys 
145                 150                 155                 160 


Asn Gln Tyr Tyr Leu Asp Leu Asn Ser Val Thr Thr Glu Asp Thr Ala 
                165                 170                 175     


Thr Tyr Tyr Cys Ala Asn Trp Asp Gly Asp Tyr Trp Gly Gln Gly Thr 
            180                 185                 190         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        195                 200                 205             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    210                 215                 220                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
225                 230                 235                 240 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                245                 250                 255     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            260                 265                 270         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        275                 280                 285             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    290                 295                 300             


<210>  30
<211>  299
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  30

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
                85                  90                  95      


Ser Val Thr Pro Gly Asn Ser Val Ser Leu Ser Cys Arg Ala Ser Gln 
            100                 105                 110         


Ser Ile Gly Asn Asn Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser 
        115                 120                 125             


Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro 
    130                 135                 140                 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile 
145                 150                 155                 160 


Asn Ser Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser 
                165                 170                 175     


Asn Ser Trp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            180                 185                 190         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        195                 200                 205             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    210                 215                 220                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
225                 230                 235                 240 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                245                 250                 255     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            260                 265                 270         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        275                 280                 285             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    290                 295                 


<210>  31
<211>  915
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  31
atgagattcc catctatttt caccgctgtc ttgttcgctg cctcctctgc attggctgcc       60

cctgttaaca ctaccactga agacgagact gctcaaattc cagctgaagc agttatcggt      120

tactctgacc ttgagggtga tttcgacgtc gctgttttgc ctttctctaa ctccactaac      180

aacggtttgt tgttcattaa caccactatc gcttccattg ctgctaagga agagggtgtc      240

tctctcgaga agagagacgt tcaattgcaa gaatctggtc catccttggt taagccatcc      300

cagactttgt ccttgacttg ttccgttact ggtgactcca tcacttctga ctactggtcc      360

tggatcagaa agttcccagg taacagattg gagtacatgg gttacgtttc ttactccggt      420

tccacttact acaacccatc cttgaagtcc agaatctcca tcactagaga cacttccaag      480

aaccagtact acttggactt gaactccgtt actactgagg acactgctac ttactactgt      540

gctaactggg acggtgacta ttggggtcaa ggtactttgg ttactgtttc ctccgcttcc      600

actaagggtc catctgtttt tccattggct ccatcctcca agtctacttc aggtggtact      660

gctgctttgg gttgtttggt taaggactac ttcccagagc cagttactgt ttcttggaac      720

tccggtgctt tgacttccgg tgttcacact ttcccagctg tcttgcaatc ctccggtctg      780

tactccttgt cctccgttgt tactgttcct tcttcctcct tgggtactca aacttacatc      840

tgtaacgtta accacaagcc atccaacact aaggttgaca agagagttga gccaaagtcc      900

tgtgacaagt aatag                                                       915


<210>  32
<211>  903
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  32
atgagattcc catctatttt caccgctgtc ttgttcgctg cctcctctgc attggctgcc       60

cctgttaaca ctaccactga agacgagact gctcaaattc cagctgaagc agttatcggt      120

tactctgacc ttgagggtga tttcgacgtc gctgttttgc ctttctctaa ctccactaac      180

aacggtttgt tgttcattaa caccactatc gcttccattg ctgctaagga agagggtgtc      240

tctctcgaga agagagacat cgttttgact caatccccag ctactttgtc cgttactcca      300

ggtaactccg tttccttgtc ctgtagagct tcccagtcca tcggtaacaa cttgcactgg      360

tatcagcaga agtctcacga gtccccaaga ctgttgatca agtacgcttc ccaatccatc      420

tccggtatcc catctagatt ctctggttct ggttccggta ctgacttcac tttgtccatc      480

aactccgttg agactgagga cttcggtatg tacttctgtc agcaatccaa ctcctggcca      540

tacacttttg gtggtggtac taagttggag atcaagagaa ctgttgctgc tccatccgtt      600

ttcatcttcc caccatctga cgagcagttg aagtctggta ctgcttccgt tgtttgtttg      660

ttgaacaact tctacccaag agaagctaag gttcagtgga aggttgacaa cgccttgcaa      720

tccggtaact cccaagagtc cgttactgaa caagactcca aggactctac ttactccttg      780

tcctccactt tgactttgtc caaggctgac tacgagaagc acaaggttta cgcttgtgag      840

gttactcacc agggtttgtc ctccccagtt actaagtcct tcaacagagg tgagtgttaa      900

tag                                                                    903


<210>  33
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  33
actacctgca ggcgaaacga tgagattccc atc                                    33


<210>  34
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  34
tcatggccga ggcggcccta ttacttgtca caggactttg gctc                        44


<210>  35
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  35
ctatggccga ggcggcccta ttaacactca cctctgttg                              39


<210>  36
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  36
tatcggccga ggcggcccta ttacttacct ggggacaag                              39


<210>  37
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  37
ctatggccga ggcggcccta ttaacactca cctctgttg                              39


<210>  38
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  38
cttgcctgca ggatgctaac ggccagttgg tc                                     32


<210>  39
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  39
gatcggccga ggcggcctca gcagtattcc caccagaatc                             40


<210>  40
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  40
cttgcctgca ggatgtcagt tcatttcgtt atagcagc                               38


<210>  41
<211>  52
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  41
gatcggccga ggcggcctca tataaaaggt ttatcataat tctcatcctc ag               52


<210>  42
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  42
gaaacctgca ggatgtctga atttgttgct aaaattaaca ttc                         43


<210>  43
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  43
gatcggccga ggcggcctta ggcggttgga acgttc                                 36


<210>  44
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  44
gaaacctgca ggatgtctca tctattactg cgtgacagc                              39


<210>  45
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  45
gatcggccga ggcggcctca tggcccggca tatctag                                37


<210>  46
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  46
gacacctgca ggatgtctga atcctccagt atctctctag ttg                         43


<210>  47
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  47
gatcggccga ggcggcccta gatacatccc aaaagtgcac cg                          42


<210>  48
<211>  34
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  48
gatacctgca ggatgatcct gggttcagtt tggg                                   34


<210>  49
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  49
gatcggccga ggcggcccta aaagtttgct gcagcatttg aag                         43


<210>  50
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  50
cttgcctgca ggatgggttg ctttagattt tgtctgg                                37


<210>  51
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  51
gatcggccga ggcggcccta tttgtatacg tgctgtggag cc                          42


<210>  52
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  52
cttgcctgca ggatgttaaa caagctgttc attgcaatac tc                          42


<210>  53
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  53
gatcggccga ggcggcctta gctggcaagg gtaattgtct c                           41


<210>  54
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  54
gacacctgca ggatggctcc tcaaacacca agg                                    33


<210>  55
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  55
gatcggccga ggcggcctca aaaaaacaat ctcaaaatct ccag                        44


<210>  56
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  56
gtaccctgca ggatgaccaa ggaaaatgaa gcc                                    33


<210>  57
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  57
gatcggccga ggcggcctta ttttttctcc aattcagcca g                           41


<210>  58
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  58
gaaacctgca ggatgctgtt gtcacatacc atgatacttc                             40


<210>  59
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  59
gatcggccga ggcggcctta agattgcttc tttttgagat tgg                         43


<210>  60
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  60
gaaacctgca ggatgacgga ctatgtcact tctaagcg                               38


<210>  61
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  61
gatcggccga ggcggcctca taatctccct ccagggg                                37


<210>  62
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  62
gaaacctgca ggatgtcgtc tgatgctgtg gag                                    33


<210>  63
<211>  46
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  63
gatcggccga ggcggcctca aataatgcta catttgcgtt tctttc                      46


<210>  64
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  64
cttgcctgca ggatgtctta tacgtcggac aacaaagag                              39


<210>  65
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  65
gatcggccga ggcggcctta cgtgtatccg cttcctctgt ac                          42


<210>  66
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  66
gatacctgca ggatgaactt gtacctaatt acattactat tcgc                        44


<210>  67
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  67
gatcggccga ggcggcctta gaacccacat tgatttggat actg                        44


<210>  68
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  68
gaaacctgca ggatgtcgtt atcaaccttt ctaggcg                                37


<210>  69
<211>  47
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  69
gatcggccga ggcggcctca gactctactc atcattttgt cttcctc                     47


<210>  70
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  70
gaaacctgca ggatgatgta caggaactta ataattgcta ctgc                        44


<210>  71
<211>  48
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  71
gatcggccga ggcggcccta acactctatg aggtctacaa tgtccaac                    48


<210>  72
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  72
catgcctgca ggatgtctac agcaattcca ggaggac                                37


<210>  73
<211>  46
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  73
gatcggccga ggcggcctta gttgatcaac tttcctgtca gcttag                      46


<210>  74
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  74
gacacctgca ggatgagtgg tgaccataag agctttacg                              39


<210>  75
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  75
gatcggccga ggcggcctta ctgtgtacca taccgatcca atcc                        44


<210>  76
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  76
cttgcctgca ggatgactaa ctggaaagcg atattgactc c                           41


<210>  77
<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  77
gatcggccga ggcggcctta gttctcttct tcaccttgaa attttaggc                   49


<210>  78
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  78
gcaacctgca ggatgtctta tcgccctcag tttcaac                                37


<210>  79
<211>  51
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  79
gatcggccga ggcggcctca atagatcttt ttcttttcat caaaactcaa c                51


<210>  80
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  80
gatacctgca ggatggtggt gcacaaccct aataac                                 36


<210>  81
<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  81
gatcggccga ggcggcccta ggtactatgc tgaacatcct gagtatgag                   49


<210>  82
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  82
gaaacctgca ggatgagatt ttctaacgtc gttttaactg c                           41


<210>  83
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  83
gatcggccga ggcggcctta caaggcaaag actccgaaag tg                          42


<210>  84
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  84
gacacctgca ggatgactgt gcctgatctg aaagaaac                               38


<210>  85
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  85
gatcggccga ggcggcctca ggccagcgca acg                                    33


<210>  86
<211>  46
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  86
cttgcctgca ggatgaagat atggctggta cttcttttag tttttg                      46


<210>  87
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  87
gatcggccga ggcggcctca caattcgtct ctaatttgtt gcg                         43


<210>  88
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  88
cttgcctgca ggatggagca ggttccagtc g                                      31


<210>  89
<211>  47
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  89
gatcggccga ggcggcctta ttcatcataa acttcttcta tggtggc                     47


<210>  90
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  90
cttgcctgca ggatggatcc tttttcaatt cttctcac                               38


<210>  91
<211>  47
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  91
gatcggccga ggcggcccta ctttggagac agatcttcca ccttaac                     47


<210>  92
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  92
gaaacctgca ggatgaccag tcaaggattt ttggatc                                37


<210>  93
<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  93
gatcggccga ggcggcccta tatgctatca accatctcca tcaaataac                   49


<210>  94
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  94
gacacctgca ggatgactcc ccgttctcat attttc                                 36


<210>  95
<211>  50
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  95
gatcggccga ggcggcccta ctcaaagaac ttagacaaag cagctttctc                  50


<210>  96
<211>  29
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  96
gatccctgca ggatggcaga agaagaacc                                         29


<210>  97
<211>  54
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  97
gatcggccga ggcggcccta attagtaata cttgcttcta tttcctggta caac             54


<210>  98
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  98
gaaccctgca ggatgatttt gagcaagctg tcgtttagac                             40


<210>  99
<211>  51
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  99
gatcggccga ggcggcctta tttattaaca atgacatcat cttcaaactc g                51


<210>  100
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  100
cttgcctgca ggatgggtgc cattggaatg                                        30


<210>  101
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  101
gatcggccga ggcggcccta ttgcagaaca ttcgatatcc aatc                        44


<210>  102
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  102
gatacctgca ggatgctacc attttcgtac gacgtg                                 36


<210>  103
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  103
gatcggccga ggcggcccta taactctcca ttctcctcgt cgatc                       45


<210>  104
<211>  47
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  104
gatccctgca ggatgaaaat attaagtgca ttgcttcttc tttttac                     47


<210>  105
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  105
gatcggccga ggcggcctta tagctcttgg tgtaataact gggg                        44


<210>  106
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  106
cttgcctgca ggatgtctaa accctacaag ctgataggtg ag                          42


<210>  107
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  107
gatcggccga ggcggcctta atcttctcca gcaggtatct catcc                       45


<210>  108
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  108
cttgcctgca ggatgaatca attttctcta gcttcacaag taaac                       45


<210>  109
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  109
gatcggccga ggcggcccta ctcggttaat ggtccgagtg c                           41


<210>  110
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  110
gacacctgca ggatgagtta taggaaagac aacaaacaaa ag                          42


<210>  111
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  111
gatcggccga ggcggcctta gaaggcagct tcatcatcg                              39


<210>  112
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  112
cttgcctgca ggatgagcag cttcagagtt ctagacttgg                             40


<210>  113
<211>  35
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  113
gatcggccga ggcggcctta cagatcaacg aatcc                                  35


<210>  114
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  114
gatacctgca ggatgaacat ctttagaatc ctaggtaagt ttcc                        44


<210>  115
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  115
gatcggccga ggcggcctca ttctggcagc ttgaatttc                              39


<210>  116
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  116
cttgcctgca ggatgtccac aactactaag aaaaacaaga acagg                       45


<210>  117
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  117
gatcggccga ggcggcctta ccatgcaccc tttcctctc                              39


<210>  118
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  118
cttgcctgca ggatgtcaga ggagtaagaa ccacaaacag                             40


<210>  119
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  119
gatcggccga ggcggcctca atttattcta ggttttttgg ttcgg                       45


<210>  120
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  120
gtaccctgca ggatgatggc aagtccaacc g                                      31


<210>  121
<211>  34
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  121
gatcggccga ggcggcccgc aacaacgctg gttg                                   34


<210>  122
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  122
cttgcctgca ggatgagtaa ccagtataat ccgtatgagc ag                          42


<210>  123
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  123
gatcggccga ggcggcccta tcttccccag tttccgacac                             40


<210>  124
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  124
gttacctgca ggatgtctac agagaacaaa gcagagacaa aac                         43


<210>  125
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  125
gatcggccga ggcggcccta tttctttgct tcagcgtttg c                           41


<210>  126
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  126
cttgcctgca ggatgttaaa cttaatatcc acaataagtg ggtg                        44


<210>  127
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  127
gatcggccga ggcggcctta agcaggagca gataaccaag c                           41


<210>  128
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  128
cttgcctgca ggatgggtag aaggaaaata gagataaatc cg                          42


<210>  129
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  129
gatcggccga ggcggcctca gctcttctta gtcacactgc ttg                         43


<210>  130
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  130
cttgcctgca ggatgtcact tcaactgtcc attatcttcg                             40


<210>  131
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  131
gatcggccga ggcggcccta ctcgtccttc ttgttgctct tctc                        44


<210>  132
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  132
cgaacatcca tcaccaaaac ac                                                22


<210>  133
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  133
gttgtcgacc tgcagcgtac ggtgttgccg cgaaatg                                37


<210>  134
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  134
catttcgcgg caacaccgta cgctgcaggt cgacaac                                37


<210>  135
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  135
cggtgagaat ggcaaaagct tatg                                              24


<210>  136
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  136
aagcccgatg cgccagagtt g                                                 21


<210>  137
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  137
cgtctcttgg gcaaattgat cagtggatct gatatcacct a                           41


<210>  138
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  138
taggtgatat cagatccact gatcaatttg cccaagagac g                           41


<210>  139
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  139
gactgttgcg attgctggtg                                                   20


<210>  140
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  140
atccaggaca cgctcatcaa g                                                 21


<210>  141
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  141
gtgtgtgctc tggaattgga tc                                                22


<210>  142
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  142
agaggaggtt gaatgcgaag aag                                               23


<210>  143
<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  143
gttgtcgacc tgcagcgtac ttctggtgag cttatatggc agtagttac                   49


<210>  144
<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  144
gtaactactg ccatataagc tcaccagaag tacgctgcag gtcgacaac                   49


<210>  145
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  145
cggtgagaat ggcaaaagct tatg                                              24


<210>  146
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  146
aagcccgatg cgccagagtt g                                                 21


<210>  147
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  147
ctcgggatca ccaagcacaa gtggatctga tatcaccta                              39


<210>  148
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  148
taggtgatat cagatccact tgtgcttggt gatcccgag                              39


<210>  149
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  149
tcaaagtatg ctgggaagaa tgg                                               23


<210>  150
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  150
tggattgtct cggaggcg                                                     18


<210>  151
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  151
tactatgact atgggagacc tgggtg                                            26


<210>  152
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  152
tgaagcatcc cacccactg                                                    19


<210>  153
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  153
gttgtcgacc tgcagcgtac ccttcgcaga ctgtaattat tggc                        44


<210>  154
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  154
gccaataatt acagtctgcg aagggtacgc tgcaggtcga caac                        44


<210>  155
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  155
cggtgagaat ggcaaaagct tatg                                              24


<210>  156
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  156
aagcccgatg cgccagagtt g                                                 21


<210>  157
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  157
gttgactttg acggttgcag atacagtgga tctgatatca ccta                        44


<210>  158
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  158
taggtgatat cagatccact gtatctgcaa ccgtcaaagt caac                        44


<210>  159
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  159
ttctctcctt gattatcggt ctctttc                                           27


<210>  160
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  160
tggcagatga cttcacaaac g                                                 21


<210>  161
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  161
gtggcatctt tcataacgac atctc                                             25


<210>  162
<211>  478
<212>  PRT
<213>  Pichia pastoris

<400>  162

Met Ser Ser Phe Arg Val Leu Asp Leu Val Lys Pro Phe Thr Pro Phe 
1               5                   10                  15      


Leu Pro Glu Val Ile Ser Pro Glu Arg Lys Val Pro Phe Gln Gln Lys 
            20                  25                  30          


Leu Met Trp Thr Gly Val Thr Leu Leu Ile Phe Leu Val Met Ser Glu 
        35                  40                  45              


Ile Pro Leu Tyr Gly Ile Thr Ser Ser Asp Ser Ser Asp Pro Leu Phe 
    50                  55                  60                  


Trp Leu Arg Met Met Leu Ala Ser Asn Arg Gly Thr Leu Met Glu Leu 
65                  70                  75                  80  


Gly Ile Ser Pro Ile Val Thr Ser Gly Met Val Phe Gln Leu Leu Gln 
                85                  90                  95      


Gly Ile Gln Ile Leu Asp Val Asn Met Glu Asn Lys Ala Asp Arg Glu 
            100                 105                 110         


Leu Phe Gln Thr Ala Gln Lys Val Phe Ala Ile Leu Leu Ser Ile Gly 
        115                 120                 125             


Gln Ala Thr Val Tyr Val Leu Thr Gly Met Tyr Gly Pro Pro Gly Glu 
    130                 135                 140                 


Leu Gly Val Gly Val Cys Leu Leu Leu Val Leu Gln Leu Val Phe Ala 
145                 150                 155                 160 


Gly Ile Val Val Ile Leu Leu Asp Glu Leu Leu Gln Lys Gly Tyr Gly 
                165                 170                 175     


Leu Gly Ser Gly Ile Ser Leu Phe Met Ala Thr Asn Ile Cys Glu Gln 
            180                 185                 190         


Ile Phe Trp Lys Thr Phe Ala Pro Thr Thr Val Asn Arg Gly Arg Gly 
        195                 200                 205             


Lys Glu Phe Glu Gly Ala Phe Ile Ser Phe Phe His Leu Ile Leu Thr 
    210                 215                 220                 


Lys Lys Asp Lys Lys Arg Ala Leu Leu Glu Ser Phe Tyr Arg Asp Asn 
225                 230                 235                 240 


Ala Pro Asn Met Phe Gln Val Ile Ala Thr Leu Val Val Phe Phe Thr 
                245                 250                 255     


Val Val Tyr Leu Gln Gly Phe Arg Leu Glu Ile Pro Val Lys Ser Thr 
            260                 265                 270         


Arg Gln Arg Gly Pro Tyr Gly Thr Tyr Pro Ile Arg Leu Phe Tyr Thr 
        275                 280                 285             


Ser Asn Met Pro Ile Met Leu Gln Ser Ala Leu Thr Ser Asn Ile Phe 
    290                 295                 300                 


Ile Ile Ser Gln Met Leu Tyr Ser His Phe Pro Asp Asn Ala Phe Val 
305                 310                 315                 320 


Lys Leu Ile Gly Thr Trp Glu Ala Gln Pro Gly Ser Ala Gln Leu Phe 
                325                 330                 335     


Ala Ala Ser Gly Leu Ala Tyr Tyr Met Gln Pro Pro Met Ser Leu Ser 
            340                 345                 350         


Gln Ala Leu Leu Asp Pro Ile Lys Thr Val Val Tyr Val Val Phe Val 
        355                 360                 365             


Leu Thr Thr Cys Ala Ile Phe Ser Lys Thr Trp Ile Glu Ile Ser Gly 
    370                 375                 380                 


Ser Ser Pro Arg Asp Val Ala Lys Gln Phe Lys Asp Gln Gly Leu Val 
385                 390                 395                 400 


Ile Ala Gly His Arg Asp Ala Thr Val Tyr Lys Glu Leu Lys Lys Ile 
                405                 410                 415     


Ile Pro Thr Ala Ala Ala Phe Gly Gly Ala Thr Ile Gly Ala Leu Ser 
            420                 425                 430         


Val Val Ser Asp Leu Leu Gly Thr Leu Gly Ser Gly Thr Ser Ile Leu 
        435                 440                 445             


Leu Ala Val Thr Thr Ile Tyr Gly Tyr Tyr Glu Leu Ala Val Lys Glu 
    450                 455                 460                 


Gly Gly Phe Ser Lys Gly Gly Pro Ser Gly Phe Val Asp Leu 
465                 470                 475             


<210>  163
<211>  1437
<212>  DNA
<213>  Pichia pastoris

<400>  163
atgagcagct tcagagttct agacttggta aagcccttta ccccatttct gcctgaggtt       60

atctctccag agagaaaggt cccctttcaa cagaagttga tgtggactgg agtcactctt      120

ctgatcttct tggtcatgag tgaaattccc ctgtatggta tcacttcaag tgactcctct      180

gaccctttgt tttggctgcg tatgatgttg gcctctaaca gaggaacgct gatggagtta      240

ggtatctctc ctattgtcac ttctggaatg gtgttccaac tgttgcaggg aatccaaatc      300

ttggacgtga acatggaaaa caaagcagac agagagttgt tccaaactgc tcaaaaagtg      360

ttcgccattt tgctgagtat cggacaagct actgtttatg ttttaactgg aatgtatggc      420

ccccctggtg aactaggagt tggtgtctgt cttttgttgg ttcttcaatt ggtgtttgca      480

ggtattgtgg tcattttgtt ggatgaactc ttacaaaaag gttacggttt aggaagtgga      540

atttctcttt tcatggccac caacatttgt gagcagattt tttggaagac ttttgctcct      600

accaccgtta accgtggaag aggtaaggaa tttgaaggag ctttcatttc tttctttcac      660

ctgatcttga ccaagaagga caagaagaga gctctgttgg aatcatttta cagagacaac      720

gctccaaaca tgttccaagt tattgctact cttgtcgtct ttttcaccgt tgtctatctt      780

cagggcttcc gtttggagat tccagttaag tctacccgtc aaagaggtcc ttacggaact      840

tacccaatca gattgttcta cacatccaac atgccaatca tgttacaatc cgctttgacc      900

tcaaacattt tcattatttc ccagatgttg tattcacact tccctgacaa tgcctttgtt      960

aagctcattg gaacttggga agctcaacct ggttcagcac aactgtttgc tgcctcggga     1020

ttagcctact acatgcagcc tccaatgtcc ctgagtcaag ctttattaga ccctatcaag     1080

actgtcgtct acgttgtgtt tgttttgacc acttgtgcca tcttctccaa gacatggatt     1140

gagatttcgg gatcttcccc aagagacgtt gctaagcaat tcaaagacca aggattggtt     1200

attgctggac acagagatgc tactgtttac aaggagttga agaagattat accaacagcc     1260

gctgcatttg gaggtgccac aattggtgca ctttccgttg tttccgacct tttgggtact     1320

ttaggttcgg gaacctccat ccttttggct gttacaacca tctatggtta ctacgagttg     1380

gctgttaagg aaggtggttt ttcaaagggt ggaccctctg gattcgttga tctgtaa        1437


